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Naoto Oku

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Kanae Ichikawa; Tatsuhiro Ishida; Hiroto Kawashima; Hiroshi Kiwada; Haruna Miyauchi; Kosuke Shimizu; Takeo Urakami; Sei Yonezawa; Tomohiro Asai; Naoto Oku
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
Hiroyuki Takahama; Masaki Yamato; Naoto Oku; Keiji Okuda; Shoji Sanada; Hirokazu Shigematsu; Tomohiro Asai; Masanori Asakura; Yoshihiro Asano; Hiroshi Asanuma; Hai Ying Fu; Masafumi Kitakaze; Issei Komuro; Takashi Matsuzaki; Tetsuo Minamino
Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.
Takayuki Ishii; Tetsuo Minamino; Yurika Agato; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Kosuke Shimizu; Nodoka Yasuda; Naoto Oku
Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506.

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2013: Kanae Ichikawa; Tatsuhiro Ishida; Hiroto Kawashima; Hiroshi Kiwada; Haruna Miyauchi; Kosuke Shimizu; Takeo Urakami; Sei Yonezawa; Tomohiro Asai; Naoto Oku
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
Journal of controlled release : official journal of the Controlled Release Society 2013;167(3):284-9.
2013: Hiroyuki Takahama; Masaki Yamato; Naoto Oku; Keiji Okuda; Shoji Sanada; Hirokazu Shigematsu; Tomohiro Asai; Masanori Asakura; Yoshihiro Asano; Hiroshi Asanuma; Hai Ying Fu; Masafumi Kitakaze; Issei Komuro; Takashi Matsuzaki; Tetsuo Minamino
Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2013;27(2):125-32.
2013: Takayuki Ishii; Tetsuo Minamino; Yurika Agato; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Kosuke Shimizu; Nodoka Yasuda; Naoto Oku
Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1362-70.
2013: Kosuke Shimizu; Arina Uchiyama; Mina Yamashita; Akihiko Hirose; Tetsuji Nishimura; Naoto Oku
Biomembrane damage caused by exposure to multi-walled carbon nanotubes.
The Journal of toxicological sciences 2013;38(1):7-12.
2013: Takayuki Ishii; Akira T Kawaguchi; Yurika Agato; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Kosuke Shimizu; Nodoka Yasuda; Naoto Oku
Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.
Biochemical and biophysical research communications 2013;430(4):1201-5.
2013: Eriya Kenjo; Mamoru Nango; Hidenori Ando; Tomohiro Asai; Takehisa Dewa; Kentaro Hatanaka; Takayuki Ishii; Kosuke Shimizu; Hideo Tsukada; Yugo Urita; Norihito Yonenaga; Naoto Oku
Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.
Biological & pharmaceutical bulletin 2013;36(2):287-91.
2013: Hidenori Ando; Tomohiro Asai; Takehisa Dewa; Ayaka Okamoto; Kosuke Shimizu; Masafumi Yokota; Naoto Oku
Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy.
The journal of gene medicine 2013;15(1):20-7.
2012: Takayuki Ishii; Tetsuo Minamino; Yurika Agato; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Kosuke Shimizu; Nodoka Yasuda; Naoto Oku
A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion.
International journal of pharmaceutics 2012;439(1-2):269-74.
2012: Hiroyuki Koide; Hidenori Ando; Tomohiro Asai; Hiroki Kato; Kouichi Shiraishi; Masayuki Yokoyama; Naoto Oku
Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.
International journal of pharmaceutics 2012;432(1-2):75-9.
2012: Kaoru Nishikawa; Naoto Oku; Hirokazu Shigematsu; Kosuke Shimizu; Seiji Takashima; Tomohiro Asai; Yoshihiro Asano; Hisakazu Kato; Eisuke Mekada; Tetsuo Minamino
Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):274-80.
2012: Norihito Yonenaga; Kosuke Shimizu; Atsushi Tsuruta; Tomohiro Asai; Takehisa Dewa; Eriya Kenjo; Mamoru Nango; Naoto Oku
RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):177-81.
2012: Takayuki Ishii; Tetsuo Minamino; Tomohiro Asai; Tatsuya Fukuta; Dai Oyama; Kosuke Shimizu; Nodoka Yasuda; Naoto Oku
Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(1):81-7.
2012: Atsushi Takeda; Haruna Tamano; Kazuki Ide; Haruka Iwaki; Naoto Oku
Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice.
Brain research bulletin 2012;87(6):551-5.
2012: Atsushi Takeda; Haruna Tamano; Kazuki Ide; Miki Suzuki; Shunsuke Takada; Naoto Oku
Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress.
Neurochemistry international 2012;60(4):394-9.
2012: Atsushi Takeda; Masaki Ando; Kosuke Itagaki; Naoto Oku
Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus.
Journal of neuroscience research 2012;90(3):551-8.
2012: Makoto Ogata; Naoto Oku; Enoch Y Park; Seiichiro Umemura; Tomohiro Asai; Yuka Kobayashi; Ichiro Matsuo; Takeomi Murata; Naoki Nakamura; Megumi Yano; Taichi Usui
Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties.
Bioconjugate chemistry 2012;23(1):97-105.
2012: Hidenori Ando; Tomohiro Asai; Norihiro Harada; Kentaro Hatanaka; Hiroyuki Koide; Hideo Tsukada; Takuma Tsuzuku; Norihito Yonenaga; Naoto Oku
[In vivo imaging of liposomal small interfering RNA (siRNA) trafficking by positron emission tomography].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(12):1373-81.
2012: Atsushi Takeda; Haruna Tamano; Masaki Ando; Taisuke Ogawa; Naoto Oku; Shunsuke Takada; Mitsugu Watanabe
Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency.
Behavioural brain research 2012;226(1):259-64.
2012: Atsushi Takeda; Haruna Tamano; Naoto Oku; Kazuhiro Sakamoto; Miki Suzuki; Hidehiko Yokogoshi
Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response.
Cellular and molecular neurobiology 2012;32(1):41-8.
2011: Atsushi Maeda; Tatsuki Shinoda; Naoki Ito; Keizo Baba; Naoto Oku; Takao Mizumoto
Evaluating tamsulosin hydrochloride-released microparticles prepared using single-step matrix coating.
International journal of pharmaceutics 2011;408(1-2):84-90.
2011: Tomohiro Asai; Saori Matsushita; Eriya Kenjo; Takuma Tsuzuku; Norihito Yonenaga; Hiroyuki Koide; Kentaro Hatanaka; Takehisa Dewa; Mamoru Nango; Noriyuki Maeda; Hiroshi Kikuchi; Naoto Oku
Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.
Bioconjugate chemistry 2011;22(3):429-35.
2011: Tomohiro Asakawa; Aiki Hiza; Miho Nakayama; Makoto Inai; Dai Oyama; Hiroyuki Koide; Kosuke Shimizu; Toshiyuki Wakimoto; Norihiro Harada; Hideo Tsukada; Naoto Oku; Toshiyuki Kan
PET imaging of nobiletin based on a practical total synthesis.
Chemical communications (Cambridge, England) 2011;47(10):2868-70.
2011: Atsushi Yoshida; Yasuo Hirooka; Yusuke Sugata; Mariko Nitta; Tamiko Manabe; Shunsuke Ido; Kouki Murakami; Repon Kumer Saha; Takashi Suzuki; Motohiro Ohshima; Akira Yoshida; Kunihiko Itoh; Kosuke Shimizu; Naoto Oku; Takumi Furuta; Tomohiro Asakawa; Toshiyuki Wakimoto; Toshiyuki Kan
Concise synthesis of catechin probes enabling analysis and imaging of EGCg.
Chemical communications (Cambridge, England) 2011;47(6):1794-6.
2011: Naoto Oku; Mina Yamashita; Yurie Katayama; Takeo Urakami; Kentaro Hatanaka; Kosuke Shimizu; Tomohiro Asai; Hideo Tsukada; Shuji Akai; Hiroaki Kanazawa
PET imaging of brain cancer with positron emitter-labeled liposomes.
International journal of pharmaceutics 2011;403(1-2):170-7.
2011: Hiroyuki Koide; Tomohiro Asai; Keiichi Furuya; Takuma Tsuzuku; Hiroki Kato; Takehisa Dewa; Mamoru Nango; Noriyuki Maeda; Naoto Oku
Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector.
Biological & pharmaceutical bulletin 2011;34(5):602-8.
2011: Takuya Umemoto; Tomohiro Asai; Koji Hirashima; Kosuke Shimizu; Motohiro Mihara; Koji Yamamoto; Koji Kubota; Shin-ichi Miyagawa; Naoto Oku
Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction.
Biological & pharmaceutical bulletin 2011;34(4):551-4.
2011: Suratsawadee Piyaviriyakul; Kosuke Shimizu; Tomohiro Asakawa; Toshiyuki Kan; Pongpun Siripong; Naoto Oku
Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs.
Biological & pharmaceutical bulletin 2011;34(3):396-400.
2010: Yasufumi Katanasaka; Takayuki Ishii; Tomohiro Asai; Hirotaka Naitou; Noriyuki Maeda; Fumiaki Koizumi; Shinichi Miyagawa; Norio Ohashi; Naoto Oku
Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.
International journal of cancer. Journal international du cancer 2010;127(11):2685-98.
2010: Haruna Tamano; Fumika Kan; Naoto Oku; Atsushi Takeda
Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice.
Brain research bulletin 2010;83(6):351-5.
2010: Masaki Ando; Naoto Oku; Atsushi Takeda
Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin.
Neurochemistry international 2010;57(5):608-14.
2010: Atsushi Takeda; Haruna Tamano; S Imano; Naoto Oku
Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear.
Neuroscience 2010;168(3):715-22.
2010: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Shuji Akai; Takayuki Ishii; Eriya Kenjo; Tatsuhiro Ishida; Hiroshi Kiwada; Hideo Tsukada; Naoto Oku
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.
International journal of pharmaceutics 2010;392(1-2):218-23.
2010: Takehisa Dewa; Tomohiro Asai; Yuka Tsunoda; Kiyoshi Kato; Daisuke Baba; Misa Uchida; Ayumi Sumino; Kayoko Niwata; Takuya Umemoto; Kouji Iida; Naoto Oku; Mamoru Nango
Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity.
Bioconjugate chemistry 2010;21(5):844-52.
2010: Atsushi Takeda; Haruka Iwaki; Masaki Ando; Kosuke Itagaki; Miki Suzuki; Naoto Oku
Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses.
Brain research 2010;1323():59-64.
2010: Takayuki Ishii; Tomohiro Asai; Takeo Urakami; Naoto Oku
Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.
Brain research 2010;1321():164-8.
2010: Yuki Murase; Tomohiro Asai; Yasufumi Katanasaka; Tomoki Sugiyama; Kosuke Shimizu; Noriyuki Maeda; Naoto Oku
A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.
Cancer letters 2010;287(2):165-71.
2010: Kosuke Shimizu; Masaaki Osada; Koji Takemoto; Yutaka Yamamoto; Tomohiro Asai; Naoto Oku
Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):208-15.
2010: Tomohiro Asai; Naoto Oku
Angiogenic vessel-targeting DDS by liposomalized oligopeptides.
Methods in molecular biology (Clifton, N.J.) 2010;605():335-47.
2010: Kosuke Shimizu; Naomi Kinouchi Shimizu; Wakako Hakamata; Keiko Unno; Tomohiro Asai; Naoto Oku
Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.
Biological & pharmaceutical bulletin 2010;33(1):117-21.
2009: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Kosuke Shimizu; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku
[Elucidation of accelerated blood clearance phenomenon caused by repeat injection of PEGylated nanocarriers].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(12):1445-51.
2009: Haruna Tamano; Fumika Kan; Mika Kawamura; Naoto Oku; Atsushi Takeda
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation.
Neurochemistry international 2009;55(7):536-41.
2009: Atsushi Takeda; Naomi Sakurada; Masaki Ando; Shingo Kanno; Naoto Oku
Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus.
Neurochemistry international 2009;55(6):376-82.
2009: Atsushi Takeda; Masaki Ando; Shingo Kanno; Naoto Oku
Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation.
Neurotoxicology 2009;30(4):712-7.
2009: Takeo Urakami; Koichi Sakai; Tomohiro Asai; Dai Fukumoto; Hideo Tsukada; Naoto Oku
Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.
Nuclear medicine and biology 2009;36(3):295-303.
2009: Hiroyuki Takahama; Tetsuo Minamino; Hiroshi Asanuma; Masashi Fujita; Tomohiro Asai; Masakatsu Wakeno; Hideyuki Sasaki; Hiroshi Kikuchi; Kouichi Hashimoto; Naoto Oku; Masanori Asakura; Jiyoong Kim; Seiji Takashima; Kazuo Komamura; Masaru Sugimachi; Naoki Mochizuki; Masafumi Kitakaze
Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.
Journal of the American College of Cardiology 2009;53(8):709-17.
2009: Takeo Urakami; Akira T Kawaguchi; Shuji Akai; Kentaro Hatanaka; Hiroyuki Koide; Kosuke Shimizu; Tomohiro Asai; Dai Fukumoto; Norihiro Harada; Hideo Tsukada; Naoto Oku
In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.
Artificial organs 2009;33(2):164-8.
2009: Atsushi Takeda; Sayuri Fuke; M Ando; Naoto Oku
Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc.
Neuroscience 2009;158(2):585-91.
2009: Atsushi Takeda; Hiromasa Itoh; Akito Nagayoshi; Naoto Oku
Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet.
Epilepsy research 2009;83(1):73-80.
2008: Atsushi Takeda; Haruna Tamano; Hiromasa Itoh; Naoto Oku
Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan.
Neurochemistry international 2008;53(6-8):230-5.
2008: Yasuyuki Sadzuka; Fumiaki Iwasaki; Ikumi Sugiyama; Kentaro Horiuchi; Toru Hirano; Hidechika Ozawa; Naohiro Kanayama; Naoto Oku
Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization.
Toxicology letters 2008;182(1-3):110-4.
2008: Yasufumi Katanasaka; Tomoko Ida; Tomohiro Asai; Kosuke Shimizu; Fumiaki Koizumi; Noriyuki Maeda; Kazuhiko Baba; Naoto Oku
Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416.
Cancer letters 2008;270(2):260-8.
2008: Kentaro Hatanaka; Kosuke Shimizu; Tomohiro Asai; Naoto Oku
[Antineovascular gene therapy by Ago2 knockdown].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(11):1567-75.
2008: Hiroyuki Koide; Tomohiro Asai; Kentaro Hatanaka; Takeo Urakami; Takayuki Ishii; Eriya Kenjo; Masamichi Nishihara; Masayuki Yokoyama; Tatsuhiro Ishida; Hiroshi Kiwada; Naoto Oku
Particle size-dependent triggering of accelerated blood clearance phenomenon.
International journal of pharmaceutics 2008;362(1-2):197-200.
2008: Atsushi Takeda; Shingo Kanno; Naomi Sakurada; Masaki Ando; Naoto Oku
Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc.
Journal of neuroscience research 2008;86(13):2906-11.
2008: Atsushi Takeda; Hiromasa Itoh; Kohei Yamada; Haruna Tamano; Naoto Oku
Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2008;21(5):545-52.
2008: Shuji Maruyama; Hideo Tsukada; Shingo Nishiyama; Takeharu Kakiuchi; Dai Fukumoto; Naoto Oku; Shizuo Yamada
In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment.
The Journal of pharmacology and experimental therapeutics 2008;325(3):774-81.
2008: Kosuke Shimizu; Naomi Kinouchi Shimizu; Tomohiro Asai; Hideo Tsukada; Naoto Oku
Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.
Biological & pharmaceutical bulletin 2008;31(5):847-51.
2008: Tomohiro Asai; Souichiro Miyazawa; Noriyuki Maeda; Kentaro Hatanaka; Yasufumi Katanasaka; Kosuke Shimizu; Satoshi Shuto; Naoto Oku
Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.
Cancer science 2008;99(5):1029-33.
2008: Atsushi Takeda; Haruna Tamano; Fumika Kan; Tomoyuki Hanajima; Kohei Yamada; Naoto Oku
Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency.
Life sciences 2008;82(17-18):909-14.
2008: Tomohiro Asai; Yuko Suzuki; Saori Matsushita; Sei Yonezawa; Junichi Yokota; Yasufumi Katanasaka; Tatsuhiro Ishida; Takehisa Dewa; Hiroshi Kiwada; Mamoru Nango; Naoto Oku
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.
Biochemical and biophysical research communications 2008;368(2):243-8.
2008: Hiromichi Imanaka; Hiroyuki Koide; Kosuke Shimizu; Tomohiro Asai; Naomi Kinouchi Shimizu; Atsushi Ishikado; Taketoshi Makino; Naoto Oku
Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.
Biological & pharmaceutical bulletin 2008;31(3):400-4.
2008: Atsushi Takeda; Hiromasa Itoh; Haruna Tamano; Mitsutoshi Yuzurihara; Naoto Oku
Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats.
Nutritional neuroscience 2008;11(1):41-6.
2008: Kosuke Shimizu; Yasuharu Sawazaki; Toshiki Tanaka; Tomohiro Asai; Naoto Oku
Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug.
Biological & pharmaceutical bulletin 2008;31(1):95-8.
2008: Atsushi Takeda; Kohei Yamada; Haruna Tamano; Sayuri Fuke; Mika Kawamura; Naoto Oku
Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency.
Neurochemistry international 2008;52(1-2):241-6.
2007: Yasufumi Katanasaka; Tomohiro Asai; Hirotaka Naitou; Norio Ohashi; Naoto Oku
Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium.
Biological & pharmaceutical bulletin 2007;30(12):2300-7.
2007: Atsushi Takeda; Sayuri Fuke; Wataru Tsutsumi; Naoto Oku
Negative modulation of presynaptic activity by zinc released from Schaffer collaterals.
Journal of neuroscience research 2007;85(16):3666-72.
2007: Takahiro Kishido; Keiko Unno; Hirotoshi Yoshida; Daisuke Choba; Rie Fukutomi; Shunsuke Asahina; Kazuaki Iguchi; Naoto Oku; Minoru Hoshino
Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain.
Biogerontology 2007;8(4):423-30.
2007: Atsushi Takeda; Sayuri Fuke; Akira Minami; Naoto Oku
Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release.
Journal of neuroscience research 2007;85(6):1310-7.
2007: Sei Yonezawa; Tomohiro Asai; Naoto Oku
Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(3):303-9.
2007: Keiko Unno; Fumiyo Takabayashi; Hirotoshi Yoshida; Daisuke Choba; Rie Fukutomi; Naomi Kikunaga; Takahiro Kishido; Naoto Oku; Minoru Hoshino
Daily consumption of green tea catechin delays memory regression in aged mice.
Biogerontology 2007;8(2):89-95.
2007: Chiaki Fuse; Yuuki Ishida; Tomoya Hikita; Tomohiro Asai; Naoto Oku
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma.
The Journal of biological chemistry 2007;282(11):8276-83.
2007: Atsushi Takeda; Haruna Tamano; Fumika Kan; Hiromasa Itoh; Naoto Oku
Anxiety-like behavior of young rats after 2-week zinc deprivation.
Behavioural brain research 2007;177(1):1-6.
2007: Atsushi Takeda; Akira Minami; Naomi Sakurada; Satoko Nakajima; Naoto Oku
Response of hippocampal mossy fiber zinc to excessive glutamate release.
Neurochemistry international 2007;50(2):322-7.
2006: Atsushi Takeda; Hiromasa Itoh; Sachie Imano; Naoto Oku
Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation.
Neurochemistry international 2006;49(8):746-50.
2006: Atsushi Takeda; Sachie Imano; Hiromasa Itoh; Naoto Oku
Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex.
Brain research 2006;1118(1):52-7.
2006: Atsushi Takeda; Hiromasa Itoh; Haruna Tamano; Naoto Oku
Responsiveness to kainate in young rats after 2-week zinc deprivation.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2006;19(5):565-72.
2006: Atsushi Takeda; Naomi Sakurada; Shingo Kanno; Akira Minami; Naoto Oku
Response of extracellular zinc in the ventral hippocampus against novelty stress.
Journal of neurochemistry 2006;99(2):670-6.
2006: Yasuyuki Sadzuka; Koji Tokutomi; Fumiaki Iwasaki; Ikumi Sugiyama; Toru Hirano; Hiroyuki Konno; Naoto Oku; Takashi Sonobe
The phototoxicity of photofrin was enhanced by PEGylated liposome in vitro.
Cancer letters 2006;241(1):42-8.
2006: Noriyuki Maeda; Souichiro Miyazawa; Kosuke Shimizu; Tomohiro Asai; Sei Yonezawa; Sadaya Kitazawa; Yukihiro Namba; Hideo Tsukada; Naoto Oku
Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.
Biological & pharmaceutical bulletin 2006;29(9):1936-40.
2006: Atsushi Takeda; Hiromasa Itoh; Maki Hirate; Naoto Oku
Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency.
Epilepsy research 2006;70(1):41-8.
2006: Atsushi Takeda; Satoko Nakajima; Sayuri Fuke; Naomi Sakurada; Akira Minami; Naoto Oku
Zinc release from Schaffer collaterals and its significance.
Brain research bulletin 2006;68(6):442-7.
2006: Akira Minami; Naomi Sakurada; Sayuri Fuke; Kazuya Kikuchi; Tetsuo Nagano; Naoto Oku; Atsushi Takeda
Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation.
Journal of neuroscience research 2006;83(1):167-76.
2005: Atsushi Takeda; Haruna Tamano; Akito Nagayoshi; Kohei Yamada; Naoto Oku
Increase in hippocampal cell death after treatment with kainate in zinc deficiency.
Neurochemistry international 2005;47(8):539-44.
2005: Atsushi Takeda; Haruna Tamano; Naoto Oku
Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats.
Epilepsy research 2005;66(1-3):137-43.
2005: Kanae Ichikawa; Tomoya Hikita; Noriyuki Maeda; Sei Yonezawa; Yoshito Takeuchi; Tomohiro Asai; Yukihiro Namba; Naoto Oku
Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels.
Biochimica et biophysica acta 2005;1669(1):69-74.
2005: Keiko Unno; Naoko Hagima; Takahiro Kishido; Shoji Okada; Naoto Oku
Deuterium-resistant algal cell line for D labeling of heterotrophs expresses enhanced level of Hsp60 in D2O medium.
Applied and environmental microbiology 2005;71(5):2256-9.
2005: Keiko Goto; Tomohiro Asai; Shuntaro Hara; Ichiji Namatame; Hiroshi Tomoda; Mamoru Ikemoto; Naoto Oku
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Cancer letters 2005;219(2):215-22.
2005: Atsushi Takeda; Kohei Yamada; Akira Minami; Tetsuo Nagano; Naoto Oku
Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency.
Epilepsy research 2005;63(2-3):77-84.
2005: Atsushi Takeda; Haruna Tamano; Minori Tochigi; Naoto Oku
Zinc homeostasis in the hippocampus of zinc-deficient young adult rats.
Neurochemistry international 2005;46(3):221-5.
2005: Tomohiro Asai; Naoto Oku
Liposomalized oligopeptides in cancer therapy.
Methods in enzymology 2005;391():163-76.
2005: Naoto Oku; Yukihiro Namba
Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents.
Methods in enzymology 2005;391():145-62.
2004: Noriyuki Maeda; Yoshito Takeuchi; Miki Takada; Yasuyuki Sadzuka; Yukihiro Namba; Naoto Oku
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):41-52.
2004: Satoru Yamakawa; Tomohiro Asai; Takayuki Uchida; Motomi Matsukawa; Toshifumi Akizawa; Naoto Oku
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
Cancer letters 2004;210(1):47-55.
2004: Takehisa Dewa; Yukari Ieda; Kazuyuki Morita; Li Wang; Robert C MacDonald; Kouji Iida; Keiji Yamashita; Naoto Oku; Mamoru Nango
Novel polyamine-dialkyl phosphate conjugates for gene carriers. Facile synthetic route via an unprecedented dialkyl phosphate.
Bioconjugate chemistry 2004;15(4):824-30.
2004: Keiko Unno; Fumiyo Takabayashi; Takahiro Kishido; Naoto Oku
Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10).
Experimental gerontology 2004;39(7):1027-34.
2004: Yoshito Takeuchi; Kanae Ichikawa; Sei Yonezawa; Kohta Kurohane; Takayuki Koishi; Mamoru Nango; Yukihiro Namba; Naoto Oku
Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(2):231-40.
2004: Michie Tamura; Keiko Unno; Sei Yonezawa; Kenji Hattori; Emi Nakashima; Hideo Tsukada; Motowo Nakajima; Naoto Oku
In vivo trafficking of endothelial progenitor cells their possible involvement in the tumor neovascularization.
Life sciences 2004;75(5):575-84.
2004: Kosuke Shimizu; Naoto Oku
Cancer anti-angiogenic therapy.
Biological & pharmaceutical bulletin 2004;27(5):599-605.
2004: Atsushi Takeda; Akira Minami; Yumiko Seki; Satoko Nakajima; Naoto Oku
Release of amino acids by zinc in the hippocampus.
Brain research bulletin 2004;63(3):253-7.
2004: Atsushi Takeda; Maki Hirate; Naoto Oku
Elimination of zinc-65 from the brain under kainate-induced seizures.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2004;17(2):141-4.
2004: Atsushi Takeda; Akira Minami; Rie Yamaide; Naoto Oku
Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance.
Neuroscience letters 2004;358(2):119-22.
2004: Kanae Ichikawa; Yoshito Takeuchi; Sei Yonezawa; Tomoya Hikita; Kohta Kurohane; Yukihiro Namba; Naoto Oku
Antiangiogenic photodynamic therapy (PDT) using Visudyne causes effective suppression of tumor growth.
Cancer letters 2004;205(1):39-48.
2004: Kanae Ichikawa; Tomoya Hikita; Noriyuki Maeda; Yoshito Takeuchi; Yukihiro Namba; Naoto Oku
PEGylation of liposome decreases the susceptibility of liposomal drug in cancer photodynamic therapy.
Biological & pharmaceutical bulletin 2004;27(3):443-4.
2004: Noriyuki Maeda; Yoshito Takeuchi; Miki Takada; Yukihiro Namba; Naoto Oku
Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate.
Bioorganic & medicinal chemistry letters 2004;14(4):1015-7.
2004: Mayu Sugiyama; Mituso Matsuura; Yoshito Takeuchi; Jun Kosaka; Mamoru Nango; Naoto Oku
Possible mechanism of polycation liposome (PCL)-mediated gene transfer.
Biochimica et biophysica acta 2004;1660(1-2):24-30.
2004: Atsushi Takeda; Akira Minami; Yumiko Seki; Naoto Oku
Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus.
Journal of neuroscience research 2004;75(2):225-9.
2004: Masami Kondo; Tomohiro Asai; Yasufumi Katanasaka; Yasuyuki Sadzuka; Hideo Tsukada; Koichi Ogino; Takao Taki; Kazuhiko Baba; Naoto Oku
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
International journal of cancer. Journal international du cancer 2004;108(2):301-6.
2003: Atsushi Takeda; Akira Minami; Yumiko Seki; Naoto Oku
Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons.
Epilepsy research 2003;57(2-3):169-74.
2003: Naoto Oku; Motomi Matsukawa; Satoru Yamakawa; Tomohiro Asai; Shoji Yahara; Fumio Hashimoto; Toshifumi Akizawa
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
Biological & pharmaceutical bulletin 2003;26(9):1235-8.
2003: Yoshito Takeuchi; Kohta Kurohane; Kanae Ichikawa; Sei Yonezawa; Hidetsugu Ori; Takayuki Koishi; Mamoru Nango; Naoto Oku
Polycation liposome enhances the endocytic uptake of photosensitizer into cells in the presence of serum.
Bioconjugate chemistry 2003;14(4):790-6.
2003: Mitsuo Matsuura; Yukako Yamazaki; Mayu Sugiyama; Masami Kondo; Hidetsugu Ori; Mamoru Nango; Naoto Oku
Polycation liposome-mediated gene transfer in vivo.
Biochimica et biophysica acta 2003;1612(2):136-43.
2003: Keiko Unno; Takahiro Kishido; Mizue Morioka; Shoji Okada; Naoto Oku
Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line.
Biological & pharmaceutical bulletin 2003;26(6):799-802.
2003: Atsushi Takeda; Maki Hirate; Haruna Tamano; Daisuke Nisibaba; Naoto Oku
Susceptibility to kainate-induced seizures under dietary zinc deficiency.
Journal of neurochemistry 2003;85(6):1575-80.
2003: Atsushi Takeda; Maki Hirate; Haruna Tamano; Naoto Oku
Release of glutamate and GABA in the hippocampus under zinc deficiency.
Journal of neuroscience research 2003;72(4):537-42.
2003: Atsushi Takeda; Maki Hirate; Haruna Tamano; Naoto Oku
Zinc movement in the brain under kainate-induced seizures.
Epilepsy research 2003;54(2-3):123-9.
2003: Seiichiro Minato; Kazunori Iwanaga; Masawo Kakemi; Shinji Yamashita; Naoto Oku
Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(2):189-97.
2003: Yoshito Takeuchi; Kohta Kurohane; Kanae Ichikawa; Sei Yonezawa; Mamoru Nango; Naoto Oku
Induction of intensive tumor suppression by antiangiogenic photodynamic therapy using polycation-modified liposomal photosensitizer.
Cancer 2003;97(8):2027-34.
2003: Atsushi Takeda; Naoki Sotogaku; Naoto Oku
Influence of manganese on the release of neurotransmitters in rat striatum.
Brain research 2003;965(1-2):279-82.
2003: Atsushi Takeda; Haruna Tamano; Naoto Oku
Alteration of zinc concentrations in the brain implanted with C6 glioma.
Brain research 2003;965(1-2):170-3.
2003: Naoto Oku; Tomohiro Asai; Koh Watanabe; Koichi Kuromi; Koichi Ogino; Takao Taki
Anti-neovascular therapy by use of liposomes targeted to angiogenic vessels.
Journal of liposome research 2003;13(1):25-7.
2002: Atsushi Takeda; Mai Suzuki; Naoto Oku
Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(4):371-5.
2002: Kosuke Shimizu; Miki Takada; Tomohiro Asai; Koichi Kuromi; Kazuhiko Baba; Naoto Oku
Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent.
Biological & pharmaceutical bulletin 2002;25(10):1385-7.
2002: Atsushi Takeda; Keiko Takatsuka; Naoki Sotogaku; Naoto Oku
Influence of iron-saturation of plasma transferrin in iron distribution in the brain.
Neurochemistry international 2002;41(4):223-8.
2002: Maki Hirate; Atsushi Takeda; Haruna Tamano; Shuichi Enomoto; Naoto Oku
Distribution of trace elements in the brain of EL (epilepsy) mice.
Epilepsy research 2002;51(1-2):109-16.
2002: Keiko Unno; Hiromi Asakura; Yuka Shibuya; Masako Kaihou; Hideto Fukatsu; Shoji Okada; Naoto Oku
Stress response caused by chronic alcohol intake in aged rat brain.
Alcoholism, clinical and experimental research 2002;26(7):1017-23.
2002: Tomohiro Asai; Hideto Fukatsu; Koichi Kuromi; Koichi Ogino; Michinori Tanaka; Naoto Oku; Takao Taki
Isolation of a novel peptide homing to tumor-derived neovasculature that suppresses tumor growth.
Biological & pharmaceutical bulletin 2002;25(7):904-6.
2002: Tomohiro Asai; Kosuke Shimizu; Masami Kondo; Koichi Kuromi; Koh Watanabe; Koichi Ogino; Takao Taki; Satoshi Shuto; Akira Matsuda; Naoto Oku
Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels.
FEBS letters 2002;520(1-3):167-70.
2002: Kosuke Shimizu; Miki Takada; Tomohiro Asai; Kenji Irimura; Kazuhiko Baba; Naoto Oku
Potential usage of liposomal 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53) for cancer chemotherapy.
Biological & pharmaceutical bulletin 2002;25(6):783-6.
2002: Akira Minami; Atsushi Takeda; Rie Yamaide; Naoto Oku
Relationship between zinc and neurotransmitters released into the amygdalar extracellular space.
Brain research 2002;936(1-2):91-4.
2002: Haruna Tamano; Shuichi Enomoto; Naoto Oku; Atsushi Takeda
Preferential uptake of zinc, manganese, and rubidium in rat brain tumor.
Nuclear medicine and biology 2002;29(4):505-8.
2002: Naoto Oku; Tomohiro Asai; Koh Watanabe; Koichi Kuromi; Mayumi Nagatsuka; Kohta Kurohane; Hironori Kikkawa; Koichi Ogino; Michinori Tanaka; Dai Ishikawa; Hideo Tsukada; Masanobu Momose; Jun Nakayama; Takao Taki
Anti-neovascular therapy using novel peptides homing to angiogenic vessels.
Oncogene 2002;21(17):2662-9.
2002: Atsushi Takeda; Keiko Takatsuka; James Connor; Naoto Oku
Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(1):33-6.
2002: Tomohiro Asai; Mayumi Nagatsuka; Koichi Kuromi; Satoru Yamakawa; Kohta Kurohane; Koichi Ogino; Michinori Tanaka; Takao Taki; Naoto Oku
Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels.
FEBS letters 2002;510(3):206-10.
2002: Hironori Kikkawa; Masako Kaihou; Natsuko Horaguchi; Takayuki Uchida; Hidetoshi Imafuku; Ayano Takiguchi; Yukako Yamazaki; Chieko Koike; Ryoko Kuruto; Takeharu Kakiuchi; Hideo Tsukada; Yoshikazu Takada; Nariaki Matsuura; Naoto Oku
Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses.
Clinical & experimental metastasis 2002;19(8):717-25.
2002: Atsushi Takeda; Naoki Sotogaku; Naoto Oku
Manganese influences the levels of neurotransmitters in synapses in rat brain.
Neuroscience 2002;114(3):669-74.
2002: Yoshito Takeuchi; Kohta Kurohane; Mamoru Nango; Naoto Oku
Intensive tumor suppression by anti-angiogenic photodynamic therapy with polycation-modified liposomal photosensitizer.
Cellular & molecular biology letters 2002;7(2):301.
2002: Naoto Oku; Tomohiro Asai; Kohta Kurohane; Koh Watanabe; Koichi Kuromi; Yukihiro Namba; Koichi Ogino; Takao Taki
Cancer antineovascular therapy.
Cellular & molecular biology letters 2002;7(2):247-8.
2001: Naoto Oku; Yukako Yamazaki; Mitsuo Matsuura; Mayu Sugiyama; M Hasegawa; Mamoru Nango
A novel non-viral gene transfer system, polycation liposomes.
Advanced drug delivery reviews 2001;52(3):209-18.
2001: Atsushi Takeda; Keiko Takatsuka; James Connor; Naoto Oku
Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice.
Brain research 2001;912(2):154-61.
2001: Atsushi Takeda; Haruna Tamano; Shuichi Enomoto; Naoto Oku
Zinc-65 imaging of rat brain tumors.
Cancer research 2001;61(13):5065-9.
2001: Kohta Kurohane; A Tominaga; K Sato; J R North; Yukihiro Namba; Naoto Oku
Photodynamic therapy targeted to tumor-induced angiogenic vessels.
Cancer letters 2001;167(1):49-56.
2001: Akira Minami; Atsushi Takeda; D Nishibaba; S Takefuta; Naoto Oku
Cadmium toxicity in synaptic neurotransmission in the brain.
Brain research 2001;894(2):336-9.
2001: Atsushi Takeda; Akira Minami; S Takefuta; M Tochigi; Naoto Oku
Zinc homeostasis in the brain of adult rats fed zinc-deficient diet.
Journal of neuroscience research 2001;63(5):447-52.
2001: Tomohiro Asai; S Shuto; A Matsuda; T Kakiuchi; H Ohba; Hideo Tsukada; Naoto Oku
Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.
Cancer letters 2001;162(1):49-56.
2000: Kohta Kurohane; Yukihiro Namba; Naoto Oku
Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells.
Life sciences 2000;68(3):273-81.
2000: Satoru Yamakawa; Y Furuyama; Naoto Oku
Development of a Simple Cell Invasion Assay System.
Biological & pharmaceutical bulletin 2000;23(10):1264-6.
2000: Hironori Kikkawa; Hideo Tsukada; Naoto Oku
Usefulness of positron emission tomographic visualization for examination of in vivo susceptibility to metastasis.
Cancer 2000;89(7):1626-33.
2000: Naoki Sotogaku; Naoto Oku; Atsushi Takeda
Manganese concentration in mouse brain after intravenous injection.
Journal of neuroscience research 2000;61(3):350-6.
2000: Y Yuyama; M Tsujimoto; Y Fujimoto; Naoto Oku
Potential usage of thermosensitive liposomes for site-specific delivery of cytokines.
Cancer letters 2000;155(1):71-7.
2000: Yukako Yamazaki; Mamoru Nango; Mitsuo Matsuura; Y Hasegawa; M Hasegawa; Naoto Oku
Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine.
Gene therapy 2000;7(13):1148-55.
2000: Keiko Unno; H Asakura; Y Shibuya; M Kaiho; Shoji Okada; Naoto Oku
Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(7):B329-35.
2000: Atsushi Takeda; Motohisa Suzuki; S Okada; Naoto Oku
65Zn localization in rat brain after intracerebroventricular injection of 65Zn-histidine.
Brain research 2000;863(1-2):241-4.
2000: Atsushi Takeda; S Takefuta; S Okada; Naoto Oku
Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet.
Brain research 2000;859(2):352-7.
2000: Hironori Kikkawa; Hidetoshi Imafuku; Hideo Tsukada; Naoto Oku
Possible role of immune surveillance at the initial phase of metastasis produced by B16BL6 melanoma cells.
FEBS letters 2000;467(2-3):211-6.
2000: M Takikawa; Hironori Kikkawa; Tomohiro Asai; N Yamaguchi; Dai Ishikawa; Michinori Tanaka; Koichi Ogino; Takao Taki; Naoto Oku
Suppression of GD1alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide.
FEBS letters 2000;466(2-3):381-4.
2000: Y Fujimoto; Y Okuhata; S Tyngi; Yukihiro Namba; Naoto Oku
Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium-diethylenetriamine pentaacetic acid.
Biological & pharmaceutical bulletin 2000;23(1):97-100.
1999: Atsushi Takeda; S Takefuta; H Ijiro; S Okada; Naoto Oku
109Cd transport in rat brain.
Brain research bulletin 1999;49(6):453-7.
1999: Atsushi Takeda; T Hanajima; H Ijiro; A Ishige; S Iizuka; S Okada; Naoto Oku
Release of zinc from the brain of El (epilepsy) mice during seizure induction.
Brain research 1999;828(1-2):174-8.
1998: Dai Ishikawa; Hironori Kikkawa; Koichi Ogino; Y Hirabayashi; Naoto Oku; Takao Taki
GD1alpha-replica peptides functionally mimic GD1alpha, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis.
FEBS letters 1998;441(1):20-4.
1998: Hironori Kikkawa; Daisei Miyamoto; Hidetoshi Imafuku; Chieko Koike; Yasuo Suzuki; S Okada; Hideo Tsukada; T Irimura; Naoto Oku
Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells.
Japanese journal of cancer research : Gann 1998;89(12):1296-305.
1998: Daisei Miyamoto; N Endo; Naoto Oku; Y Arima; Takashi Suzuki; Yasuo Suzuki
Beta-thujaplicin zinc chelate induces apoptosis in mouse high metastatic melanoma B16BL6 cells.
Biological & pharmaceutical bulletin 1998;21(12):1258-62.
1998: Tomohiro Asai; Kohta Kurohane; S Shuto; H Awano; A Matsuda; Hideo Tsukada; Yukihiro Namba; Shoji Okada; Naoto Oku
Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.
Biological & pharmaceutical bulletin 1998;21(7):766-71.
1998: Chieko Koike; M Watanabe; A Isoai; H Kumagai; Hideo Tsukada; T Irimura; S Okada; Naoto Oku
How platelet aggregation affects B16BL6 melanoma cell trafficking.
FEBS letters 1998;427(2):286-90.
1997: Chieko Koike; M Watanabe; Naoto Oku; Hideo Tsukada; T Irimura; S Okada
Tumor cells with organ-specific metastatic ability show distinctive trafficking in vivo: analyses by positron emission tomography and bioimaging.
Cancer research 1997;57(16):3612-9.
1997: Naoto Oku; N Saito; Yukihiro Namba; Hideo Tsukada; D Dolphin; Shoji Okada
Application of long-circulating liposomes to cancer photodynamic therapy.
Biological & pharmaceutical bulletin 1997;20(6):670-3.
1996: T Suzuki; A Sometani; Y Yamazaki; G Horiike; Y Mizutani; H Masuda; M Yamada; H Tahara; G Xu; Daisei Miyamoto; Naoto Oku; S Okada; M Kiso; A Hasegawa; Tadanao Ito; Yoshihiro Kawaoka; Yasuo Suzuki
Sulphatide binds to human and animal influenza A viruses, and inhibits the viral infection.
The Biochemical journal 1996;318 ( Pt 2)():389-93.
1996: Naoto Oku; Y Tokudome; Hideo Tsukada; T Kosugi; Yukihiro Namba; S Okada
In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography.
Biopharmaceutics & drug disposition 1996;17(5):435-41.
1996: T Sato; Naoto Oku; E Iida; K Kawaguchi; K Yamanaka; T Mori; S Okada
Differential effect of UV-B and UV-C on DNA damage in L-132 cells.
Biological & pharmaceutical bulletin 1996;19(5):721-5.
1996: Naoto Oku; Y Tokudome; Yukihiro Namba; N Saito; M Endo; Y Hasegawa; M Kawai; Hideo Tsukada; S Okada
Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography.
Biochimica et biophysica acta 1996;1280(1):149-54.
1996: K Kawaguchi; Naoto Oku; K Rin; K Yamanaka; S Okada
Dimethylarsenics reveal DNA damage induced by superoxide anion radicals.
Biological & pharmaceutical bulletin 1996;19(4):551-3.
1996: Y Tokudome; Naoto Oku; K Doi; Yukihiro Namba; S Okada
Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma.
Biochimica et biophysica acta 1996;1279(1):70-4.
1996: Naoto Oku; Y Tokudome; Chieko Koike; N Nishikawa; H Mori; I Saiki; S Okada
Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.
Life sciences 1996;58(24):2263-70.
1995: Chieko Koike; Naoto Oku; M Watanabe; Hideo Tsukada; T Kakiuchi; T Irimura; S Okada
Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.
Biochimica et biophysica acta 1995;1238(2):99-106.
1995: Naoto Oku; Y Tokudome; Hideo Tsukada; S Okada
Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography.
Biochimica et biophysica acta 1995;1238(1):86-90.
1995: Naoto Oku
[Basic study and application of functional liposomes].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(7):483-98.
1995: K Rin; K Kawaguchi; K Yamanaka; M Tezuka; Naoto Oku; S Okada
DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals.
Biological & pharmaceutical bulletin 1995;18(1):45-8.
1995: Naoto Oku; S Yamashita; N Sakuragi; K Doi; S Okada; K Shimidzu; M Sumi; T Nadai; S Kusumoto; Y Suda
Therapeutic efficacy of 5-fluorouracil prodrugs using endogenous serum proteins as drug carriers: a new strategy in drug delivery system.
Biological & pharmaceutical bulletin 1995;18(1):181-4.
1994: K Doi; Naoto Oku; T Toyota; S Shuto; A Sakai; H Itoh; S Okada
Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.
Biological & pharmaceutical bulletin 1994;17(10):1414-6.
1994: Naoto Oku; K Doi; Yukihiro Namba; S Okada
Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice.
International journal of cancer. Journal international du cancer 1994;58(3):415-9.
1994: Naoto Oku; Chieko Koike; M Sugawara; Hideo Tsukada; T Irimura; S Okada
Positron emission tomography analysis of metastatic tumor cell trafficking.
Cancer research 1994;54(10):2573-6.
1994: Naoto Oku; R Naruse; K Doi; S Okada
Potential usage of thermosensitive liposomes for macromolecule delivery.
Biochimica et biophysica acta 1994;1191(2):389-91.
1994: Naoto Oku; Yukihiro Namba
Long-circulating liposomes.
Critical reviews in therapeutic drug carrier systems 1994;11(4):231-70.
1993: Y Suda; K Shimidzu; M Sumi; Naoto Oku; S Kusumoto; T Nadai; S Yamashita
The synthesis and in vitro and in vivo stability of 5-fluorouracil prodrugs which possess serum albumin binding potency.
Biological & pharmaceutical bulletin 1993;16(9):876-8.
1993: Naoto Oku; Yukihiro Namba; Atsushi Takeda; S Okada
Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes.
Nuclear medicine and biology 1993;20(4):407-12.
1992: Naoto Oku; Yukihiro Namba; S Okada
Tumor accumulation of novel RES-avoiding liposomes.
Biochimica et biophysica acta 1992;1126(3):255-60.