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Naoto Oku

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
53
Takeda, Atsushi
31
Asai, Tomohiro
22
Tsukada, Hideo
21
Namba, Yukihiro
18
Tamano, Haruna
13
Minami, Akira
12
Shimizu, Kosuke
11
Kurohane, Kohta
10
Nango, Mamoru
10
Takeuchi, Yoshito
9
Taki, Takao
9
Yonezawa, Sei
9
Ogino, Koichi
9
Itoh, Hiromasa
8
Unno, Keiko

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Publications

TOP 3
Tamano Haruna; Kan Fumika; Kawamura Mika; Oku Naoto; Takeda Atsushi
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation.
Takeda Atsushi; Sakurada Naomi; Ando Masaki; Kanno Shingo; Oku Naoto
Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus.
Takeda Atsushi; Ando Masaki; Kanno Shingo; Oku Naoto
Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation.

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All Publications

2009: Tamano Haruna; Kan Fumika; Kawamura Mika; Oku Naoto; Takeda Atsushi
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation.
Neurochemistry international 2009;55(7):536-41.
2009: Takeda Atsushi; Sakurada Naomi; Ando Masaki; Kanno Shingo; Oku Naoto
Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus.
Neurochemistry international 2009;55(6):376-82.
2009: Takeda Atsushi; Ando Masaki; Kanno Shingo; Oku Naoto
Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation.
Neurotoxicology 2009;30(4):712-7.
2009: Urakami Takeo; Sakai Koichi; Asai Tomohiro; Fukumoto Dai; Tsukada Hideo; Oku Naoto
Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.
Nuclear medicine and biology 2009;36(3):295-303.
2009: Takahama Hiroyuki; Minamino Tetsuo; Asanuma Hiroshi; Fujita Masashi; Asai Tomohiro; Wakeno Masakatsu; Sasaki Hideyuki; Kikuchi Hiroshi; Hashimoto Kouichi; Oku Naoto; Asakura Masanori; Kim Jiyoong; Takashima Seiji; Komamura Kazuo; Sugimachi Masaru; Mochizuki Naoki; Kitakaze Masafumi
Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.
Journal of the American College of Cardiology 2009;53(8):709-17.
2009: Urakami Takeo; Kawaguchi Akira T; Akai Shuji; Hatanaka Kentaro; Koide Hiroyuki; Shimizu Kosuke; Asai Tomohiro; Fukumoto Dai; Harada Norihiro; Tsukada Hideo; Oku Naoto
In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.
Artificial organs 2009;33(2):164-8.
2009: Takeda Atsushi; Itoh Hiromasa; Nagayoshi Akito; Oku Naoto
Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet.
Epilepsy research 2009;83(1):73-80.
2009: Takeda A; Fuke S; Ando M; Oku N
Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc.
Neuroscience 2009;158(2):585-91.
2008: Takeda Atsushi; Tamano Haruna; Itoh Hiromasa; Oku Naoto
Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan.
Neurochemistry international 2008;53(6-8):230-5.
2008: Hatanaka Kentaro; Shimizu Kosuke; Asai Tomohiro; Oku Naoto
[Antineovascular gene therapy by Ago2 knockdown]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008;128(11):1567-75.
2008: Sadzuka Yasuyuki; Iwasaki Fumiaki; Sugiyama Ikumi; Horiuchi Kentaro; Hirano Toru; Ozawa Hidechika; Kanayama Naohiro; Oku Naoto
Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization.
Toxicology letters 2008;182(1-3):110-4.
2008: Katanasaka Yasufumi; Ida Tomoko; Asai Tomohiro; Shimizu Kosuke; Koizumi Fumiaki; Maeda Noriyuki; Baba Kazuhiko; Oku Naoto
Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416.
Cancer letters 2008;270(2):260-8.
2008: Koide Hiroyuki; Asai Tomohiro; Hatanaka Kentaro; Urakami Takeo; Ishii Takayuki; Kenjo Eriya; Nishihara Masamichi; Yokoyama Masayuki; Ishida Tatsuhiro; Kiwada Hiroshi; Oku Naoto
Particle size-dependent triggering of accelerated blood clearance phenomenon.
International journal of pharmaceutics 2008;362(1-2):197-200.
2008: Takeda Atsushi; Kanno Shingo; Sakurada Naomi; Ando Masaki; Oku Naoto
Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc.
Journal of neuroscience research 2008;86(13):2906-11.
2008: Takeda Atsushi; Itoh Hiromasa; Yamada Kohei; Tamano Haruna; Oku Naoto
Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2008;21(5):545-52.
2008: Maruyama Shuji; Tsukada Hideo; Nishiyama Shingo; Kakiuchi Takeharu; Fukumoto Dai; Oku Naoto; Yamada Shizuo
In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment.
The Journal of pharmacology and experimental therapeutics 2008;325(3):774-81.
2008: Shimizu Kosuke; Kinouchi Shimizu Naomi; Asai Tomohiro; Tsukada Hideo; Oku Naoto
Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.
Biological & pharmaceutical bulletin 2008;31(5):847-51.
2008: Asai Tomohiro; Miyazawa Souichiro; Maeda Noriyuki; Hatanaka Kentaro; Katanasaka Yasufumi; Shimizu Kosuke; Shuto Satoshi; Oku Naoto
Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.
Cancer science 2008;99(5):1029-33.
2008: Takeda Atsushi; Tamano Haruna; Kan Fumika; Hanajima Tomoyuki; Yamada Kohei; Oku Naoto
Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency.
Life sciences 2008;82(17-18):909-14.
2008: Asai Tomohiro; Suzuki Yuko; Matsushita Saori; Yonezawa Sei; Yokota Junichi; Katanasaka Yasufumi; Ishida Tatsuhiro; Dewa Takehisa; Kiwada Hiroshi; Nango Mamoru; Oku Naoto
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.
Biochemical and biophysical research communications 2008;368(2):243-8.
2008: Imanaka Hiromichi; Koide Hiroyuki; Shimizu Kosuke; Asai Tomohiro; Kinouchi Shimizu Naomi; Ishikado Atsushi; Makino Taketoshi; Oku Naoto
Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.
Biological & pharmaceutical bulletin 2008;31(3):400-4.
2008: Takeda Atsushi; Itoh Hiromasa; Tamano Haruna; Yuzurihara Mitsutoshi; Oku Naoto
Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats.
Nutritional neuroscience 2008;11(1):41-6.
2008: Shimizu Kosuke; Sawazaki Yasuharu; Tanaka Toshiki; Asai Tomohiro; Oku Naoto
Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug.
Biological & pharmaceutical bulletin 2008;31(1):95-8.
2008: Takeda Atsushi; Yamada Kohei; Tamano Haruna; Fuke Sayuri; Kawamura Mika; Oku Naoto
Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency.
Neurochemistry international 2008;52(1-2):241-6.
2007: Katanasaka Yasufumi; Asai Tomohiro; Naitou Hirotaka; Ohashi Norio; Oku Naoto
Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium.
Biological & pharmaceutical bulletin 2007;30(12):2300-7.
2007: Takeda Atsushi; Fuke Sayuri; Tsutsumi Wataru; Oku Naoto
Negative modulation of presynaptic activity by zinc released from Schaffer collaterals.
Journal of neuroscience research 2007;85(16):3666-72.
2007: Kishido Takahiro; Unno Keiko; Yoshida Hirotoshi; Choba Daisuke; Fukutomi Rie; Asahina Shunsuke; Iguchi Kazuaki; Oku Naoto; Hoshino Minoru
Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain.
Biogerontology 2007;8(4):423-30.
2007: Takeda Atsushi; Fuke Sayuri; Minami Akira; Oku Naoto
Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release.
Journal of neuroscience research 2007;85(6):1310-7.
2007: Yonezawa Sei; Asai Tomohiro; Oku Naoto
Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(3):303-9.
2007: Unno Keiko; Takabayashi Fumiyo; Yoshida Hirotoshi; Choba Daisuke; Fukutomi Rie; Kikunaga Naomi; Kishido Takahiro; Oku Naoto; Hoshino Minoru
Daily consumption of green tea catechin delays memory regression in aged mice.
Biogerontology 2007;8(2):89-95.
2007: Fuse Chiaki; Ishida Yuuki; Hikita Tomoya; Asai Tomohiro; Oku Naoto
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma.
The Journal of biological chemistry 2007;282(11):8276-83.
2007: Takeda Atsushi; Tamano Haruna; Kan Fumika; Itoh Hiromasa; Oku Naoto
Anxiety-like behavior of young rats after 2-week zinc deprivation.
Behavioural brain research 2007;177(1):1-6.
2007: Takeda Atsushi; Minami Akira; Sakurada Naomi; Nakajima Satoko; Oku Naoto
Response of hippocampal mossy fiber zinc to excessive glutamate release.
Neurochemistry international 2007;50(2):322-7.
2006: Takeda Atsushi; Itoh Hiromasa; Imano Sachie; Oku Naoto
Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation.
Neurochemistry international 2006;49(8):746-50.
2006: Takeda Atsushi; Imano Sachie; Itoh Hiromasa; Oku Naoto
Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex.
Brain research 2006;1118(1):52-7.
2006: Takeda Atsushi; Itoh Hiromasa; Tamano Haruna; Oku Naoto
Responsiveness to kainate in young rats after 2-week zinc deprivation.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2006;19(5):565-72.
2006: Takeda Atsushi; Sakurada Naomi; Kanno Shingo; Minami Akira; Oku Naoto
Response of extracellular zinc in the ventral hippocampus against novelty stress.
Journal of neurochemistry 2006;99(2):670-6.
2006: Maeda Noriyuki; Miyazawa Souichiro; Shimizu Kosuke; Asai Tomohiro; Yonezawa Sei; Kitazawa Sadaya; Namba Yukihiro; Tsukada Hideo; Oku Naoto
Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.
Biological & pharmaceutical bulletin 2006;29(9):1936-40.
2006: Sadzuka Yasuyuki; Tokutomi Koji; Iwasaki Fumiaki; Sugiyama Ikumi; Hirano Toru; Konno Hiroyuki; Oku Naoto; Sonobe Takashi
The phototoxicity of photofrin was enhanced by PEGylated liposome in vitro.
Cancer letters 2006;241(1):42-8.
2006: Takeda Atsushi; Itoh Hiromasa; Hirate Maki; Oku Naoto
Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency.
Epilepsy research 2006;70(1):41-8.
2006: Takeda Atsushi; Nakajima Satoko; Fuke Sayuri; Sakurada Naomi; Minami Akira; Oku Naoto
Zinc release from Schaffer collaterals and its significance.
Brain research bulletin 2006;68(6):442-7.
2006: Minami Akira; Sakurada Naomi; Fuke Sayuri; Kikuchi Kazuya; Nagano Tetsuo; Oku Naoto; Takeda Atsushi
Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation.
Journal of neuroscience research 2006;83(1):167-76.
2005: Takeda Atsushi; Tamano Haruna; Nagayoshi Akito; Yamada Kohei; Oku Naoto
Increase in hippocampal cell death after treatment with kainate in zinc deficiency.
Neurochemistry international 2005;47(8):539-44.
2005: Takeda Atsushi; Tamano Haruna; Oku Naoto
Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats.
Epilepsy research 2005;66(1-3):137-43.
2005: Unno Keiko; Hagima Naoko; Kishido Takahiro; Okada Shoji; Oku Naoto
Deuterium-resistant algal cell line for D labeling of heterotrophs expresses enhanced level of Hsp60 in D2O medium.
Applied and environmental microbiology 2005;71(5):2256-9.
2005: Ichikawa Kanae; Hikita Tomoya; Maeda Noriyuki; Yonezawa Sei; Takeuchi Yoshito; Asai Tomohiro; Namba Yukihiro; Oku Naoto
Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels.
Biochimica et biophysica acta 2005;1669(1):69-74.
2005: Goto Keiko; Asai Tomohiro; Hara Shuntaro; Namatame Ichiji; Tomoda Hiroshi; Ikemoto Mamoru; Oku Naoto
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Cancer letters 2005;219(2):215-22.
2005: Takeda Atsushi; Yamada Kohei; Minami Akira; Nagano Tetsuo; Oku Naoto
Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency.
Epilepsy research 2005;63(2-3):77-84.
2005: Takeda Atsushi; Tamano Haruna; Tochigi Minori; Oku Naoto
Zinc homeostasis in the hippocampus of zinc-deficient young adult rats.
Neurochemistry international 2005;46(3):221-5.
2005: Asai Tomohiro; Oku Naoto
Liposomalized oligopeptides in cancer therapy.
Methods in enzymology 2005;391():163-76.
2005: Oku Naoto; Namba Yukihiro
Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents.
Methods in enzymology 2005;391():145-62.
2004: Maeda Noriyuki; Takeuchi Yoshito; Takada Miki; Sadzuka Yasuyuki; Namba Yukihiro; Oku Naoto
Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):41-52.
2004: Dewa Takehisa; Ieda Yukari; Morita Kazuyuki; Wang Li; MacDonald Robert C; Iida Kouji; Yamashita Keiji; Oku Naoto; Nango Mamoru
Novel polyamine-dialkyl phosphate conjugates for gene carriers. Facile synthetic route via an unprecedented dialkyl phosphate.
Bioconjugate chemistry 2004;15(4):824-30.
2004: Unno Keiko; Takabayashi Fumiyo; Kishido Takahiro; Oku Naoto
Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10).
Experimental gerontology 2004;39(7):1027-34.
2004: Yamakawa Satoru; Asai Tomohiro; Uchida Takayuki; Matsukawa Motomi; Akizawa Toshifumi; Oku Naoto
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
Cancer letters 2004;210(1):47-55.
2004: Takeuchi Yoshito; Ichikawa Kanae; Yonezawa Sei; Kurohane Kohta; Koishi Takayuki; Nango Mamoru; Namba Yukihiro; Oku Naoto
Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(2):231-40.
2004: Tamura Michie; Unno Keiko; Yonezawa Sei; Hattori Kenji; Nakashima Emi; Tsukada Hideo; Nakajima Motowo; Oku Naoto
In vivo trafficking of endothelial progenitor cells their possible involvement in the tumor neovascularization.
Life sciences 2004;75(5):575-84.
2004: Shimizu Kosuke; Oku Naoto
Cancer anti-angiogenic therapy.
Biological & pharmaceutical bulletin 2004;27(5):599-605.
2004: Takeda Atsushi; Minami Akira; Seki Yumiko; Nakajima Satoko; Oku Naoto
Release of amino acids by zinc in the hippocampus.
Brain research bulletin 2004;63(3):253-7.
2004: Takeda Atsushi; Hirate Maki; Oku Naoto
Elimination of zinc-65 from the brain under kainate-induced seizures.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2004;17(2):141-4.
2004: Ichikawa Kanae; Takeuchi Yoshito; Yonezawa Sei; Hikita Tomoya; Kurohane Kohta; Namba Yukihiro; Oku Naoto
Antiangiogenic photodynamic therapy (PDT) using Visudyne causes effective suppression of tumor growth.
Cancer letters 2004;205(1):39-48.
2004: Takeda Atsushi; Minami Akira; Yamaide Rie; Oku Naoto
Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance.
Neuroscience letters 2004;358(2):119-22.
2004: Ichikawa Kanae; Hikita Tomoya; Maeda Noriyuki; Takeuchi Yoshito; Namba Yukihiro; Oku Naoto
PEGylation of liposome decreases the susceptibility of liposomal drug in cancer photodynamic therapy.
Biological & pharmaceutical bulletin 2004;27(3):443-4.
2004: Maeda Noriyuki; Takeuchi Yoshito; Takada Miki; Namba Yukihiro; Oku Naoto
Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate.
Bioorganic & medicinal chemistry letters 2004;14(4):1015-7.
2004: Sugiyama Mayu; Matsuura Mituso; Takeuchi Yoshito; Kosaka Jun; Nango Mamoru; Oku Naoto
Possible mechanism of polycation liposome (PCL)-mediated gene transfer.
Biochimica et biophysica acta 2004;1660(1-2):24-30.
2004: Takeda Atsushi; Minami Akira; Seki Yumiko; Oku Naoto
Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus.
Journal of neuroscience research 2004;75(2):225-9.
2004: Kondo Masami; Asai Tomohiro; Katanasaka Yasufumi; Sadzuka Yasuyuki; Tsukada Hideo; Ogino Koichi; Taki Takao; Baba Kazuhiko; Oku Naoto
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
International journal of cancer. Journal international du cancer 2004;108(2):301-6.
2003: Takeda Atsushi; Minami Akira; Seki Yumiko; Oku Naoto
Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons.
Epilepsy research 2003;57(2-3):169-74.
2003: Oku Naoto; Matsukawa Motomi; Yamakawa Satoru; Asai Tomohiro; Yahara Shoji; Hashimoto Fumio; Akizawa Toshifumi
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
Biological & pharmaceutical bulletin 2003;26(9):1235-8.
2003: Takeuchi Yoshito; Kurohane Kohta; Ichikawa Kanae; Yonezawa Sei; Ori Hidetsugu; Koishi Takayuki; Nango Mamoru; Oku Naoto
Polycation liposome enhances the endocytic uptake of photosensitizer into cells in the presence of serum.
Bioconjugate chemistry 2003;14(4):790-6.
2003: Unno Keiko; Kishido Takahiro; Morioka Mizue; Okada Shoji; Oku Naoto
Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line.
Biological & pharmaceutical bulletin 2003;26(6):799-802.
2003: Matsuura Mitsuo; Yamazaki Yukako; Sugiyama Mayu; Kondo Masami; Ori Hidetsugu; Nango Mamoru; Oku Naoto
Polycation liposome-mediated gene transfer in vivo.
Biochimica et biophysica acta 2003;1612(2):136-43.
2003: Takeda Atsushi; Hirate Maki; Tamano Haruna; Nisibaba Daisuke; Oku Naoto
Susceptibility to kainate-induced seizures under dietary zinc deficiency.
Journal of neurochemistry 2003;85(6):1575-80.
2003: Takeda Atsushi; Hirate Maki; Tamano Haruna; Oku Naoto
Zinc movement in the brain under kainate-induced seizures.
Epilepsy research 2003;54(2-3):123-9.
2003: Takeda Atsushi; Hirate Maki; Tamano Haruna; Oku Naoto
Release of glutamate and GABA in the hippocampus under zinc deficiency.
Journal of neuroscience research 2003;72(4):537-42.
2003: Minato Seiichiro; Iwanaga Kazunori; Kakemi Masawo; Yamashita Shinji; Oku Naoto
Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(2):189-97.
2003: Takeuchi Yoshito; Kurohane Kohta; Ichikawa Kanae; Yonezawa Sei; Nango Mamoru; Oku Naoto
Induction of intensive tumor suppression by antiangiogenic photodynamic therapy using polycation-modified liposomal photosensitizer.
Cancer 2003;97(8):2027-34.
2003: Takeda A; Sotogaku N; Oku N
Influence of manganese on the release of neurotransmitters in rat striatum.
Brain research 2003;965(1-2):279-82.
2003: Takeda Atsushi; Tamano Haruna; Oku Naoto
Alteration of zinc concentrations in the brain implanted with C6 glioma.
Brain research 2003;965(1-2):170-3.
2003: Oku N; Asai T; Watanabe K; Kuromi K; Ogino K; Taki T
Anti-neovascular therapy by use of liposomes targeted to angiogenic vessels.
Journal of liposome research 2003;13(1):25-7.
2002: Takeda Atsushi; Suzuki Mai; Oku Naoto
Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(4):371-5.
2002: Shimizu Kosuke; Takada Miki; Asai Tomohiro; Kuromi Koichi; Baba Kazuhiko; Oku Naoto
Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent.
Biological & pharmaceutical bulletin 2002;25(10):1385-7.
2002: Takeda Atsushi; Takatsuka Keiko; Sotogaku Naoki; Oku Naoto
Influence of iron-saturation of plasma transferrin in iron distribution in the brain.
Neurochemistry international 2002;41(4):223-8.
2002: Hirate Maki; Takeda Atsushi; Tamano Haruna; Enomoto Shuichi; Oku Naoto
Distribution of trace elements in the brain of EL (epilepsy) mice.
Epilepsy research 2002;51(1-2):109-16.
2002: Unno Keiko; Asakura Hiromi; Shibuya Yuka; Kaihou Masako; Fukatsu Hideto; Okada Shoji; Oku Naoto
Stress response caused by chronic alcohol intake in aged rat brain.
Alcoholism, clinical and experimental research 2002;26(7):1017-23.
2002: Asai Tomohiro; Fukatsu Hideto; Kuromi Koichi; Ogino Koichi; Tanaka Michinori; Oku Naoto; Taki Takao
Isolation of a novel peptide homing to tumor-derived neovasculature that suppresses tumor growth.
Biological & pharmaceutical bulletin 2002;25(7):904-6.
2002: Shimizu Kosuke; Takada Miki; Asai Tomohiro; Irimura Kenji; Baba Kazuhiko; Oku Naoto
Potential usage of liposomal 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53) for cancer chemotherapy.
Biological & pharmaceutical bulletin 2002;25(6):783-6.
2002: Asai Tomohiro; Shimizu Kosuke; Kondo Masami; Kuromi Koichi; Watanabe Koh; Ogino Koichi; Taki Takao; Shuto Satoshi; Matsuda Akira; Oku Naoto
Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels.
FEBS letters 2002;520(1-3):167-70.
2002: Tamano Haruna; Enomoto Shuichi; Oku Naoto; Takeda Atsushi
Preferential uptake of zinc, manganese, and rubidium in rat brain tumor.
Nuclear medicine and biology 2002;29(4):505-8.
2002: Minami Akira; Takeda Atsushi; Yamaide Rie; Oku Naoto
Relationship between zinc and neurotransmitters released into the amygdalar extracellular space.
Brain research 2002;936(1-2):91-4.
2002: Oku Naoto; Asai Tomohiro; Watanabe Koh; Kuromi Koichi; Nagatsuka Mayumi; Kurohane Kohta; Kikkawa Hironori; Ogino Koichi; Tanaka Michinori; Ishikawa Dai; Tsukada Hideo; Momose Masanobu; Nakayama Jun; Taki Takao
Anti-neovascular therapy using novel peptides homing to angiogenic vessels.
Oncogene 2002;21(17):2662-9.
2002: Takeda Atsushi; Takatsuka Keiko; Connor James R; Oku Naoto
Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(1):33-6.
2002: Asai Tomohiro; Nagatsuka Mayumi; Kuromi Koichi; Yamakawa Satoru; Kurohane Kohta; Ogino Koichi; Tanaka Michinori; Taki Takao; Oku Naoto
Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels.
FEBS letters 2002;510(3):206-10.
2002: Kikkawa Hironori; Kaihou Masako; Horaguchi Natsuko; Uchida Takayuki; Imafuku Hidetoshi; Takiguchi Ayano; Yamazaki Yukako; Koike Chieko; Kuruto Ryoko; Kakiuchi Takeharu; Tsukada Hideo; Takada Yoshikazu; Matsuura Nariaki; Oku Naoto
Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses.
Clinical & experimental metastasis 2002;19(8):717-25.
2002: Takeda A; Sotogaku N; Oku N
Manganese influences the levels of neurotransmitters in synapses in rat brain.
Neuroscience 2002;114(3):669-74.
2002: Takeuchi Yoshito; Kurohane Kohta; Nango Mamoru; Oku Naoto
Intensive tumor suppression by anti-angiogenic photodynamic therapy with polycation-modified liposomal photosensitizer.
Cellular & molecular biology letters 2002;7(2):301.
2002: Oku Naoto; Asai Tomohiro; Kurohane Kohta; Watanabe Koh; Kuromi Koichi; Namba Yukihiro; Ogino Koichi; Taki Takao
Cancer antineovascular therapy.
Cellular & molecular biology letters 2002;7(2):247-8.
2001: Oku N; Yamazaki Y; Matsuura M; Sugiyama M; Hasegawa M; Nango M
A novel non-viral gene transfer system, polycation liposomes.
Advanced drug delivery reviews 2001;52(3):209-18.
2001: Takeda A; Takatsuka K; Connor J R; Oku N
Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice.
Brain research 2001;912(2):154-61.
2001: Takeda A; Tamano H; Enomoto S; Oku N
Zinc-65 imaging of rat brain tumors.
Cancer research 2001;61(13):5065-9.
2001: Kurohane K; Tominaga A; Sato K; North J R; Namba Y; Oku N
Photodynamic therapy targeted to tumor-induced angiogenic vessels.
Cancer letters 2001;167(1):49-56.
2001: Minami A; Takeda A; Nishibaba D; Takefuta S; Oku N
Cadmium toxicity in synaptic neurotransmission in the brain.
Brain research 2001;894(2):336-9.
2001: Takeda A; Minami A; Takefuta S; Tochigi M; Oku N
Zinc homeostasis in the brain of adult rats fed zinc-deficient diet.
Journal of neuroscience research 2001;63(5):447-52.
2001: Asai T; Shuto S; Matsuda A; Kakiuchi T; Ohba H; Tsukada H; Oku N
Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.
Cancer letters 2001;162(1):49-56.
2000: Kurohane K; Namba Y; Oku N
Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells.
Life sciences 2000;68(3):273-81.
2000: Yamakawa S; Furuyama Y; Oku N
Development of a Simple Cell Invasion Assay System.
Biological & pharmaceutical bulletin 2000;23(10):1264-6.
2000: Kikkawa H; Tsukada H; Oku N
Usefulness of positron emission tomographic visualization for examination of in vivo susceptibility to metastasis.
Cancer 2000;89(7):1626-33.
2000: Sotogaku N; Oku N; Takeda A
Manganese concentration in mouse brain after intravenous injection.
Journal of neuroscience research 2000;61(3):350-6.
2000: Yamazaki Y; Nango M; Matsuura M; Hasegawa Y; Hasegawa M; Oku N
Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine.
Gene therapy 2000;7(13):1148-55.
2000: Unno K; Asakura H; Shibuya Y; Kaiho M; Okada S; Oku N
Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(7):B329-35.
2000: Yuyama Y; Tsujimoto M; Fujimoto Y; Oku N
Potential usage of thermosensitive liposomes for site-specific delivery of cytokines.
Cancer letters 2000;155(1):71-7.
2000: Takeda A; Suzuki M; Okada S; Oku N
65Zn localization in rat brain after intracerebroventricular injection of 65Zn-histidine.
Brain research 2000;863(1-2):241-4.
2000: Takeda A; Takefuta S; Okada S; Oku N
Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet.
Brain research 2000;859(2):352-7.
2000: Kikkawa H; Imafuku H; Tsukada H; Oku N
Possible role of immune surveillance at the initial phase of metastasis produced by B16BL6 melanoma cells.
FEBS letters 2000;467(2-3):211-6.
2000: Fujimoto Y; Okuhata Y; Tyngi S; Namba Y; Oku N
Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium-diethylenetriamine pentaacetic acid.
Biological & pharmaceutical bulletin 2000;23(1):97-100.
2000: Takikawa M; Kikkawa H; Asai T; Yamaguchi N; Ishikawa D; Tanaka M; Ogino K; Taki T; Oku N
Suppression of GD1alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide.
FEBS letters 2000;466(2-3):381-4.
1999: Takeda A; Takefuta S; Ijiro H; Okada S; Oku N
109Cd transport in rat brain.
Brain research bulletin 1999;49(6):453-7.
1999: Takeda A; Hanajima T; Ijiro H; Ishige A; Iizuka S; Okada S; Oku N
Release of zinc from the brain of El (epilepsy) mice during seizure induction.
Brain research 1999;828(1-2):174-8.
1998: Kikkawa H; Miyamoto D; Imafuku H; Koike C; Suzuki Y; Okada S; Tsukada H; Irimura T; Oku N
Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells.
Japanese journal of cancer research : Gann 1998;89(12):1296-305.
1998: Miyamoto D; Endo N; Oku N; Arima Y; Suzuki T; Suzuki Y
Beta-thujaplicin zinc chelate induces apoptosis in mouse high metastatic melanoma B16BL6 cells.
Biological & pharmaceutical bulletin 1998;21(12):1258-62.
1998: Ishikawa D; Kikkawa H; Ogino K; Hirabayashi Y; Oku N; Taki T
GD1alpha-replica peptides functionally mimic GD1alpha, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis.
FEBS letters 1998;441(1):20-4.
1998: Asai T; Kurohane K; Shuto S; Awano H; Matsuda A; Tsukada H; Namba Y; Okada S; Oku N
Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.
Biological & pharmaceutical bulletin 1998;21(7):766-71.
1998: Koike C; Watanabe M; Isoai A; Kumagai H; Tsukada H; Irimura T; Okada S; Oku N
How platelet aggregation affects B16BL6 melanoma cell trafficking.
FEBS letters 1998;427(2):286-90.
1997: Koike C; Watanabe M; Oku N; Tsukada H; Irimura T; Okada S
Tumor cells with organ-specific metastatic ability show distinctive trafficking in vivo: analyses by positron emission tomography and bioimaging.
Cancer research 1997;57(16):3612-9.
1997: Oku N; Saito N; Namba Y; Tsukada H; Dolphin D; Okada S
Application of long-circulating liposomes to cancer photodynamic therapy.
Biological & pharmaceutical bulletin 1997;20(6):670-3.
1996: Suzuki T; Sometani A; Yamazaki Y; Horiike G; Mizutani Y; Masuda H; Yamada M; Tahara H; Xu G; Miyamoto D; Oku N; Okada S; Kiso M; Hasegawa A; Ito T; Kawaoka Y; Suzuki Y
Sulphatide binds to human and animal influenza A viruses, and inhibits the viral infection.
The Biochemical journal 1996;318 ( Pt 2)():389-93.
1996: Oku N; Tokudome Y; Tsukada H; Kosugi T; Namba Y; Okada S
In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography.
Biopharmaceutics & drug disposition 1996;17(5):435-41.
1996: Sato T; Oku N; Iida E; Kawaguchi K; Yamanaka K; Mori T; Okada S
Differential effect of UV-B and UV-C on DNA damage in L-132 cells.
Biological & pharmaceutical bulletin 1996;19(5):721-5.
1996: Kawaguchi K; Oku N; Rin K; Yamanaka K; Okada S
Dimethylarsenics reveal DNA damage induced by superoxide anion radicals.
Biological & pharmaceutical bulletin 1996;19(4):551-3.
1996: Oku N; Tokudome Y; Namba Y; Saito N; Endo M; Hasegawa Y; Kawai M; Tsukada H; Okada S
Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography.
Biochimica et biophysica acta 1996;1280(1):149-54.
1996: Tokudome Y; Oku N; Doi K; Namba Y; Okada S
Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma.
Biochimica et biophysica acta 1996;1279(1):70-4.
1996: Oku N; Tokudome Y; Koike C; Nishikawa N; Mori H; Saiki I; Okada S
Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.
Life sciences 1996;58(24):2263-70.
1995: Koike C; Oku N; Watanabe M; Tsukada H; Kakiuchi T; Irimura T; Okada S
Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.
Biochimica et biophysica acta 1995;1238(2):99-106.
1995: Oku N; Tokudome Y; Tsukada H; Okada S
Real-time analysis of liposomal trafficking in tumor-bearing mice by use of positron emission tomography.
Biochimica et biophysica acta 1995;1238(1):86-90.
1995: Oku N
[Basic study and application of functional liposomes]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1995;115(7):483-98.
1995: Rin K; Kawaguchi K; Yamanaka K; Tezuka M; Oku N; Okada S
DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals.
Biological & pharmaceutical bulletin 1995;18(1):45-8.
1995: Oku N; Yamashita S; Sakuragi N; Doi K; Okada S; Shimidzu K; Sumi M; Nadai T; Kusumoto S; Suda Y
Therapeutic efficacy of 5-fluorouracil prodrugs using endogenous serum proteins as drug carriers: a new strategy in drug delivery system.
Biological & pharmaceutical bulletin 1995;18(1):181-4.
1994: Doi K; Oku N; Toyota T; Shuto S; Sakai A; Itoh H; Okada S
Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.
Biological & pharmaceutical bulletin 1994;17(10):1414-6.
1994: Oku N; Doi K; Namba Y; Okada S
Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice.
International journal of cancer. Journal international du cancer 1994;58(3):415-9.
1994: Oku N; Naruse R; Doi K; Okada S
Potential usage of thermosensitive liposomes for macromolecule delivery.
Biochimica et biophysica acta 1994;1191(2):389-91.
1994: Oku N; Koike C; Sugawara M; Tsukada H; Irimura T; Okada S
Positron emission tomography analysis of metastatic tumor cell trafficking.
Cancer research 1994;54(10):2573-6.
1994: Oku N; Namba Y
Long-circulating liposomes.
Critical reviews in therapeutic drug carrier systems 1994;11(4):231-70.
1993: Suda Y; Shimidzu K; Sumi M; Oku N; Kusumoto S; Nadai T; Yamashita S
The synthesis and in vitro and in vivo stability of 5-fluorouracil prodrugs which possess serum albumin binding potency.
Biological & pharmaceutical bulletin 1993;16(9):876-8.
1993: Oku N; Namba Y; Takeda A; Okada S
Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes.
Nuclear medicine and biology 1993;20(4):407-12.
1992: Oku N; Namba Y; Okada S
Tumor accumulation of novel RES-avoiding liposomes.
Biochimica et biophysica acta 1992;1126(3):255-60.

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