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Kenji Okuda

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Masaru Shimada; Kazumasa Shiozaki; Toru Takahashi; Mitsue Okuda; Keiya Ozawa; Shinya Abe; Dennis M Klinman; Hiroaki Mizukami; Kenji Okuda
Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.
Masaki Shoji; Shinji Yoshizaki; Hiroyuki Mizuguchi; Kenji Okuda; Masaru Shimada
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters.
Masaru Shimada; Shinji Yoshizaki; Nao Jounai; Asami Kondo; Motohide Ichino; Akihide Ryo; Kenji Okuda
DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity.

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All Publications

2013: Masaru Shimada; Kazumasa Shiozaki; Toru Takahashi; Mitsue Okuda; Keiya Ozawa; Shinya Abe; Dennis M Klinman; Hiroaki Mizukami; Kenji Okuda
Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.
PloS one 2013;8(3):e57606.
2012: Masaki Shoji; Shinji Yoshizaki; Hiroyuki Mizuguchi; Kenji Okuda; Masaru Shimada
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters.
PloS one 2012;7(1):e30302.
2010: Masaru Shimada; Shinji Yoshizaki; Nao Jounai; Asami Kondo; Motohide Ichino; Akihide Ryo; Kenji Okuda
DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity.
Vaccine 2010;28(31):4920-7.
2010: Sayaka Yashima; Shinji Yoshizaki; Kaori Shinoda; Atsushi Yoshida; Asami Kondo; Hiroyuki Mizuguchi; Akihide Ryo; Kenji Okuda; Masaru Shimada
Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells.
Vaccine 2010;28(18):3257-64.
2010: Kouji Kobiyama; Fumihiko Takeshita; Nao Jounai; Asako Sakaue-Sawano; Atsushi Miyawaki; Ken J Ishii; Taro Kawai; Shin Sasaki; Hisashi Hirano; Norihisa Ishii; Kenji Okuda; Koichi Suzuki
Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA.
Journal of virology 2010;84(2):822-32.
2009: Shinya Abe; Kenji Okuda; Takehiro Ura; Asami Kondo; Atsushi Yoshida; Shinji Yoshizaki; Hiroyuki Mizuguchi; Dennis Klinman; Masaru Shimada
Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5.
The journal of gene medicine 2009;11(7):570-9.
2009: Kouji Kobiyama; Fumihiko Takeshita; Ken J Ishii; Shohei Koyama; Taiki Aoshi; Shizuo Akira; Asako Sakaue-Sawano; Atsushi Miyawaki; Yuko Yamanaka; Hisashi Hirano; Koichi Suzuki; Kenji Okuda
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1593-601.
2009: Takehiro Ura; Atsushi Yoshida; Ke-Qin Xin; Shinji Yoshizaki; Sayaka Yashima; Shinya Abe; Hiroyuki Mizuguchi; Kenji Okuda
Designed recombinant adenovirus type 5 vector induced envelope-specific CD8(+) cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1.
The journal of gene medicine 2009;11(2):139-49.
2009: M Shimada; H-B Wang; A Kondo; X-P Xu; A Yoshida; K Shinoda; T Ura; H Mizuguchi; D Klinman; J-L Luo; H Bai; Kenji Okuda
Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV infection of rhesus monkeys undergoing antiretroviral therapy.
Gene therapy 2009;16(2):218-28.
2008: Fumihiko Takeshita; Kouji Kobiyama; Atsushi Miyawaki; Nao Jounai; Kenji Okuda
The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling.
Autophagy 2008;4(1):67-9.
2007: Nao Jounai; Fumihiko Takeshita; Kouji Kobiyama; Asako Sawano; Atsushi Miyawaki; Ke-Qin Xin; Ken J Ishii; Taro Kawai; Shizuo Akira; Koichi Suzuki; Kenji Okuda
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14050-5.
2007: Sukumar Saha; Fumihiko Takeshita; Tomoko Matsuda; Nao Jounai; Kouji Kobiyama; Tetsuya Matsumoto; Shin Sasaki; Atsushi Yoshida; Ke-Qin Xin; Dennis M Klinman; Satoshi Uematsu; Ken J Ishii; Shizuo Akira; Kenji Okuda
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1147-54.
2007: Nobuaki Kobayashi; Jun Yang; Atsuhisa Ueda; Takeyuki Suzuki; Kouji Tomaru; Mitsuhiro Takeno; Kenji Okuda; Yoshiaki Ishigatsubo
RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
Gene 2007;396(2):236-47.
2007: Ke-Qin Xin; Yuka Sekimoto; Toru Takahashi; Hiroyuki Mizuguchi; Motohide Ichino; Atsushi Yoshida; Kenji Okuda
Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV.
Vaccine 2007;25(19):3809-15.
2007: Keiko Watanabe-Kaneko; Tomoko Sonoda; Yohei Miyagi; Tetsuji Yamashita; Kenji Okuda; Susumu Kawamoto
The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2.
Neuroreport 2007;18(5):489-93.
2007: Fumihiko Takeshita; Keiko Takase; Miyuki Tozuka; Sukumar Saha; Kenji Okuda; Norihisa Ishii; Shin Sasaki
Muscle creatine kinase/SV40 hybrid promoter for muscle-targeted long-term transgene expression.
International journal of molecular medicine 2007;19(2):309-15.
2007: Kiyohiko Matsui; Sukumar Saha; Masaaki Saitoh; Nobuhisa Mizuki; Norihiko Itoh; Eiichi Okada; Atsushi Yoshida; Ke-Qin Xin; Osamu Nishio; Kenji Okuda
Isolation and identification of adenovirus from conjunctival scrapings over a two-year period (between 2001 and 2003) in Yokohama, Japan.
Journal of medical virology 2007;79(2):200-5.
2007: Yoshitsugu Kojima; Nao Jounai; Fumihiko Takeshita; Masatoshi Nakazawa; Kentaro Okuda; Setsuko Watabe; Ke-Qin Xin; Kenji Okuda
The degree of apoptosis as an immunostimulant for a DNA vaccine against HIV-1 infection.
Vaccine 2007;25(3):438-45.
2006: Ke-Qin Xin; Hiroaki Mizukami; Masashi Urabe; Yoshihiko Toda; Kaori Shinoda; Atsushi Yoshida; Kenji Oomura; Yoshitsugu Kojima; Motohide Ichino; Dennis M Klinman; Keiya Ozawa; Kenji Okuda
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.
Journal of virology 2006;80(24):11899-910.
2006: Tomoko Sonoda; Chieko Mochizuki; Tetsuji Yamashita; Keiko Watanabe-Kaneko; Yohei Miyagi; Yasushi Shigeri; Futoshi Yazama; Kenji Okuda; Susumu Kawamoto
Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.
Biochemical and biophysical research communications 2006;350(3):748-52.
2006: Sukumar Saha; Shinsuke Yoshida; Kenji Ohba; Kiyohiko Matsui; Tomoko Matsuda; Fumihiko Takeshita; Kazunori Umeda; Yuichi Tamura; Kentaro Okuda; Dennis M Klinman; Ke-Qin Xin; Kenji Okuda
A fused gene of nucleoprotein (NP) and herpes simplex virus genes (VP22) induces highly protective immunity against different subtypes of influenza virus.
Virology 2006;354(1):48-57.
2006: Atsushi Ihata; Setsuko Watabe; Kenji Okuda
[DNA vaccination].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(10):1865-9.
2006: Sukumar Saha; Fumihiko Takeshita; Shin Sasaki; Tomoko Matsuda; Toshiyuki Tanaka; Miyuki Tozuka; Keiko Takase; Tetsuya Matsumoto; Kenji Okuda; Norihisa Ishii; Keizo Yamaguchi; Dennis M Klinman; Ke-Qin Xin; Kenji Okuda
Multivalent DNA vaccine protects mice against pulmonary infection caused by Pseudomonas aeruginosa.
Vaccine 2006;24(37-39):6240-9.
2006: Shin Sasaki; James M Smith; Keiko Takase; Kenji Okuda; Norihisa Ishii; Fumihiko Takeshita
Activator protein 1-mediated transcriptional regulation strategy sustains long-term expression of a xenogeneic gene product in vivo: an implication for gene therapy targeting congenital protein deficiencies.
International journal of molecular medicine 2006;18(2):289-97.
2006: Eiichi Okada; Tomoko Matsuda; Tetsuro Yokoyama; Kenji Okuda
Lysozyme penetration in group IV soft contact lenses.
Eye & contact lens 2006;32(4):174-7.
2006: Fumihiko Takeshita; Toshiyuki Tanaka; Tomoko Matsuda; Miyuki Tozuka; Kouji Kobiyama; Sukumar Saha; Kiyohiko Matsui; Ken J Ishii; Cevayir Coban; Shizuo Akira; Norihisa Ishii; Koichi Suzuki; Dennis M Klinman; Kenji Okuda; Shin Sasaki
Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity.
Journal of virology 2006;80(13):6218-24.
2006: Kaori Shinoda; Ke-Qin Xin; Kenji Okuda
A modified HIV challenge assay in mice by using luciferase-expressing vaccinia virus.
Vaccine 2006;24(15):2751-4.
2006: Kaori Shinoda; Ke-Qin Xin; Yoshitsugu Kojima; Sukumar Saha; Kentaro Okuda; Kenji Okuda
Robust HIV-specific immune responses were induced by DNA vaccine prime followed by attenuated recombinant vaccinia virus (LC16m8 strain) boost.
Clinical immunology (Orlando, Fla.) 2006;119(1):32-7.
2006: Reikei Matsuda; Ann-Charlotte Boström; Malin Fredriksson; Eva-Lena Fredriksson; Göran Bratt; Bo Hejdeman; Eric Sandström; Kenji Okuda; Britta Wahren
Human immunodeficiency virus-type 1 specific cellular immunity in chronic infected patients on prolonged highly active antiretroviral treatment and on structured treatment interruption.
Microbiology and immunology 2006;50(8):629-35.
2005: Atsuo Hiraide; Naoki Yokoo; Ke-Qin Xin; Kenji Okuda; Hiroaki Mizukami; Keiya Ozawa; Tomoyuki Saito
Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.
Human gene therapy 2005;16(12):1413-21.
2005: Momoko Takakura; Fumihiko Takeshita; Michiko Aihara; Ke-Qin Xin; Motohide Ichino; Kenji Okuda; Zenro Ikezawa
Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of atopic dermatitis-like skin lesion in some NC/Nga mice.
The Journal of investigative dermatology 2005;125(6):1156-62.
2005: Ke-Qin Xin; Nao Jounai; Kenji Someya; K Honma; Hiroyuki Mizuguchi; S Naganawa; K Kitamura; T Hayakawa; Sukumar Saha; Fumihiko Takeshita; Kenji Okuda; M Honda; Dennis M Klinman; K Okuda
Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV.
Gene therapy 2005;12(24):1769-77.
2005: Tetsuji Yamashita; Yohei Miyagi; Michio Ono; Hiroaki Ito; Keiko Watanabe; Tomoko Sonoda; Keisuke Tsuzuki; Seiji Ozawa; Ichiro Aoki; Kenji Okuda; Masayoshi Mishina; Susumu Kawamoto
Identification and characterization of a novel Delphilin variant with an alternative N-terminus.
Brain research. Molecular brain research 2005;141(1):83-94.
2005: Fumihiko Takeshita; Ken J Ishii; Kouji Kobiyama; Yoshitsugu Kojima; Cevayir Coban; Shin Sasaki; Norihisa Ishii; Dennis M Klinman; Kenji Okuda; Shizuo Akira; Koichi Suzuki
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
European journal of immunology 2005;35(8):2477-85.
2005: Yan Shen; Motohide Ichino; Masatoshi Nakazawa; Takashi Ikejima; Yoshitsugu Kojima; Kenji Okuda; Mutsuhiko Minami
Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma.
Journal of autoimmunity 2005;24(3):183-90.
2005: Tomomi Ozaki; Masaomi Yauchi; Ke-Qin Xin; Fumiki Hirahara; Kenji Okuda
Cross-reactive protection against influenza A virus by a topically applied DNA vaccine encoding M gene with adjuvant.
Viral immunology 2005;18(2):373-80.
2005: Naoki Yokoo; Tomoyuki Saito; Masaaki Uesugi; Naomi Kobayashi; Ke-Qin Xin; Kenji Okuda; Hiroaki Mizukami; Keiya Ozawa; Tomihisa Koshino
Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.
Arthritis and rheumatism 2005;52(1):164-70.
2004: Claudia Devito; Bartek Zuber; Ulf Schröder; Reinhold Benthin; Kenji Okuda; Kristina Broliden; Britta Wahren; Jorma Hinkula
Intranasal HIV-1-gp160-DNA/gp41 peptide prime-boost immunization regimen in mice results in long-term HIV-1 neutralizing humoral mucosal and systemic immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):7078-89.
2004: Kaori Shinoda; Ke-Qin Xin; Nao Jounai; Yoshitsugu Kojima; Yuichi Tamura; Eiichi Okada; Susumu Kawamoto; Kenji Okuda; Dennis M Klinman; Kenji Okuda
Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice.
Vaccine 2004;22(27-28):3676-90.
2004: Jorma Hinkula; Erik Rollman; Peter Lundholm; Reinhold Benthin; Kenji Okuda; Britta Wahren
Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo.
Cells, tissues, organs 2004;177(3):169-84.
2003: Tadashi Yamakawa; Shun-ichi Tanaka; Junzo Kamei; Kazuaki Kadonosono; Kenji Okuda
Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.
European journal of pharmacology 2003;478(1):39-46.
2003: Nao Jounai; Kenji Okuda; Yoshitsugu Kojima; Yoshihiko Toda; Kenji Hamajima; Kenji Ohba; Dennis M Klinman; Ke-Qin Xin
Contribution of the rev gene to the immunogenicity of DNA vaccines targeting the envelope glycoprotein of HIV.
The journal of gene medicine 2003;5(7):609-17.
2003: Ke-Qin Xin; Yuka Hoshino; Yoshihiko Toda; Shizunobu Igimi; Yoshitsugu Kojima; Nao Jounai; Kenji Ohba; Akira Kushiro; Mayumi Kiwaki; Kenji Hamajima; Dennis M Klinman; Kenji Okuda
Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env.
Blood 2003;102(1):223-8.
2003: Ke-Qin Xin; Takaaki Ooki; Nao Jounai; Hiroaki Mizukami; Kenji Hamajima; Yoshitsugu Kojima; Kenji Ohba; Yoshihiko Toda; Syu-Ichi Hirai; Dennis M Klinman; Keiya Ozawa; Kenji Okuda
A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.
The journal of gene medicine 2003;5(5):438-45.
2003: Kenji Hamajima; Yoshizumi Kojima; Kiyohiko Matsui; Yoshihiko Toda; Nao Jounai; Tomomi Ozaki; Ke-Qin Xin; Peter Strong; Kenji Okuda
Chitin Micro-Particles (CMP): a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV-DNA vaccine.
Viral immunology 2003;16(4):541-7.
2003: Tadashi Yamakawa; Shun-ichi Tanaka; Junzo Kamei; Kazuaki Kadonosono; Kenji Okuda
Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2.
Journal of atherosclerosis and thrombosis 2003;10(1):37-42.
2002: Hidetoshi Murata; Nobuyoshi Tajima; Yoji Nagashima; Masahiro Yao; Masaya Baba; Masayuki Goto; Susumu Kawamoto; Isao Yamamoto; Kenji Okuda; Hiroshi Kanno
Von Hippel-Lindau tumor suppressor protein transforms human neuroblastoma cells into functional neuron-like cells.
Cancer research 2002;62(23):7004-11.
2002: Akiko Senuma; Eri Hagiwara; Kiyotaka Nagahama; Kenji Okuda; Mitsuyuki Nakamura; Natsuko Fukumoto; Akira Shirai; Kenji Tani; Yoshiaki Ishigatsubo
Therapeutic effect of CpG motifs on the development of chronic graft-versus-host disease in mice.
Cytokine 2002;20(1):23-9.
2002: Naomi Kobayashi; Tomihisa Koshino; Masaaki Uesugi; Naoki Yokoo; Ke-Qin Xin; Kenji Okuda; Hiroaki Mizukami; Keiya Ozawa; Tomoyuki Saito
Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair.
The Journal of rheumatology 2002;29(10):2176-80.
2002: Ke-Qin Xin; Takaaki Ooki; Hiroaki Mizukami; Kenji Hamajima; Koji Okudela; Kumiko Hashimoto; Yoshitsugu Kojima; Nao Jounai; Yasuko Kumamoto; Shin Sasaki; Dennis M Klinman; Keiya Ozawa; Kenji Okuda
Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses.
Human gene therapy 2002;13(13):1571-81.
2002: Yoshitsugu Kojima; Ke-Qin Xin; Takaaki Ooki; Kenji Hamajima; Tomohiro Oikawa; Kaori Shinoda; Tomomi Ozaki; Yuka Hoshino; Nao Jounai; Masatoshi Nakazawa; Dennis M Klinman; Kenji Okuda
Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine.
Vaccine 2002;20(23-24):2857-65.
2002: Yohei Miyagi; Tetsuji Yamashita; MASAHIRO FUKAYA; Tomoko Sonoda; Toshiaki Okuno; Kazuyuki Yamada; Masahiko Watanabe; Yoji Nagashima; Ichiro Aoki; Kenji Okuda; Masayoshi Mishina; Susumu Kawamoto
Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):803-14.
2002: Tomoyuki Saito; Ryohei Takeuchi; Kazuo Hirakawa; Nobuhito Nagata; Takuji Yoshida; Tomihisa Koshino; Kenji Okuda; Morio Takema; Toshihiko Hori
Slow-releasing potential of vancomycin-loaded porous hydroxyapatite blocks implanted into MRSA osteomyelitis.
Journal of biomedical materials research 2002;63(3):245-51.
2002: Kenji Hamajima; Yuka Hoshino; Ke-Qin Xin; Futaba Hayashi; Kazuyuki Tadokoro; Kenji Okuda
Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine.
Clinical immunology (Orlando, Fla.) 2002;102(1):12-8.
2001: Kenji Okuda; Ke-Qin Xin; Atsushi Haruki; Susumu Kawamoto; Y Kojima; Fumiki Hirahara; H Okada; Dennis M Klinman; Kenji Hamajima
Transplacental genetic immunization after intravenous delivery of plasmid DNA to pregnant mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5478-84.
2001: L J Liu; S Watabe; J Yang; Kenji Hamajima; N Ishii; Eri Hagiwara; K Onari; Ke-Qin Xin; Kenji Okuda
Topical application of HIV DNA vaccine with cytokine-expression plasmids induces strong antigen-specific immune responses.
Vaccine 2001;20(1-2):42-8.
2001: Setsuko Watabe; Ke-Qin Xin; Atsushi Ihata; L J Liu; A Honsho; I Aoki; Kenji Hamajima; Britta Wahren; Kenji Okuda
Protection against influenza virus challenge by topical application of influenza DNA vaccine.
Vaccine 2001;19(31):4434-44.
2001: Kenji Okuda; Atsushi Ihata; Setsuko Watabe; Eiichi Okada; T Yamakawa; Kenji Hamajima; J Yang; Norihisa Ishii; Masatoshi Nakazawa; K Okuda; K Ohnari; K Nakajima; Ke-Qin Xin
Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene.
Vaccine 2001;19(27):3681-91.
2001: Ke-Qin Xin; M Urabe; J Yang; Kazuo Nomiyama; Hiroaki Mizukami; Kenji Hamajima; H Nomiyama; Tomoyuki Saito; M Imai; J Monahan; Kenji Okuda; Keiya Ozawa; K Okuda
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus.
Human gene therapy 2001;12(9):1047-61.
2001: Takuji Yoshida; Kenji Okuda; Ke-Qin Xin; K Tadokoro; Jun Fukushima; S Toda; Eri Hagiwara; Kenji Hamajima; Tomihisa Koshino; Tomoyuki Saito
Activation of HIV-1-specific immune responses to an HIV-1 vaccine constructed from a replication-defective adenovirus vector using various combinations of immunization protocols.
Clinical and experimental immunology 2001;124(3):445-52.
2001: Yuki Ara; Tomoyuki Saito; T Takagi; Eri Hagiwara; Y Miyagi; M Sugiyama; Susumu Kawamoto; Norihisa Ishii; Takuji Yoshida; D Hanashi; Tomihisa Koshino; H Okada; Kenji Okuda
Zymosan enhances the immune response to DNA vaccine for human immunodeficiency virus type-1 through the activation of complement system.
Immunology 2001;103(1):98-105.
2001: J Tsuji-Yamada; M Nakazawa; K Takahashi; K Iijima; hattori shunji; Kenji Okuda; M Minami; Z Ikezawa; T Sasaki
Effect of IL-12 encoding plasmid administration on tight-skin mouse.
Biochemical and biophysical research communications 2001;280(3):707-12.
2001: T Shigematsu; Jun Fukushima; M Oyama; M Tsuda; S Kawamoto; Kenji Okuda
Iron-Mediated regulation of alkaline proteinase production in Pseudomonas aeruginosa.
Microbiology and immunology 2001;45(8):579-90.
2001: K Tadokoro; Y Koizumi; Y Miyagi; Yoshitsugu Kojima; S Kawamoto; Kenji Hamajima; Kenji Okuda; S Tanaka; K Onari; Britta Wahren; I Aoki; K Okuda
Rapid and wide-reaching delivery of HIV-1 env DNA vaccine by intranasal administration.
Viral immunology 2001;14(2):159-67.
2000: Eri Hagiwara; Takao Okubo; I Aoki; Shigeaki Ohno; Takashi Tsuji; Atsushi Ihata; Atsuhisa Ueda; Akira Shirai; Kenji Okuda; J Miyazaki; Yoshiaki Ishigatsubo
IL-12-encoding plasmid has a beneficial effect on spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.
Cytokine 2000;12(7):1035-41.
2000: H Arai; Ke-Qin Xin; Kenji Hamajima; Y Lu; Setsuko Watabe; T Takahashi; S Toda; Kenji Okuda; Ichidai Kudoh; Motoyoshi Suzuki; K Okuda
8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine.
Gene therapy 2000;7(8):694-702.
2000: H Kato; Hiroki Bukawa; Eri Hagiwara; Ke-Qin Xin; Kenji Hamajima; Susumu Kawamoto; M Sugiyama; M Sugiyama; E Noda; M Nishizaki; Kenji Okuda
Rectal and vaginal immunization with a macromolecular multicomponent peptide vaccine candidate for HIV-1 infection induces HIV-specific protective immune responses.
Vaccine 2000;18(13):1151-60.
2000: Kenji Okuda; Susumu Kawamoto; Jun Fukushima
Cytokine and costimulatory factor-encoding plasmids as adjuvants for DNA vaccination.
Methods in molecular medicine 2000;29():197-204.
2000: Kenji Hamajima; Ke-Qin Xin; Jun Fukushima; J Yang; A Honsho; M Nakazawa; Shunsuke Yanoma; Kenji Okuda
HIV-DNA vaccination following transfer of a large number of activated T cells enhances immunoresponses against HIV-1.
Viral immunology 2000;13(1):3-8.
2000: Jun Fukushima; T Inamoto; K Morihara; Kenji Okuda
[Bacterial intercellular communication and environmental adaptation].
Nihon saikingaku zasshi. Japanese journal of bacteriology 2000;55(1):37-43.
2000: Y Asakura; L J Liu; N Shono; Jorma Hinkula; Anne Kjerrström; I Aoki; Kenji Okuda; Britta Wahren; Jun Fukushima
Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production.
Clinical and experimental immunology 2000;119(1):130-9.
1999: I Aoki; S Itoh; S Yokota; S Tanaka; Norihisa Ishii; Kenji Okuda; Mutsuhiko Minami; Dennis M Klinman
Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.
Immunology 1999;98(4):519-24.
1999: Atsushi Ihata; Setsuko Watabe; Shin Sasaki; Akira Shirai; Jun Fukushima; Kenji Hamajima; J Inoue; Kenji Okuda
Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1.
Immunology 1999;98(3):436-42.
1999: Ke-Qin Xin; Kenji Hamajima; S Hattori; X R Cao; Susumu Kawamoto; Kenji Okuda
Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.
AIDS research and human retroviruses 1999;15(16):1461-7.
1999: Ke-Qin Xin; Y Lu; Kenji Hamajima; Jun Fukushima; J Yang; K Inamura; Kenji Okuda
Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity.
Clinical immunology (Orlando, Fla.) 1999;92(1):90-6.
1999: Takao Okubo; Eri Hagiwara; Shigeaki Ohno; Takashi Tsuji; Atsushi Ihata; Atsuhisa Ueda; Akira Shirai; I Aoki; Kenji Okuda; J Miyazaki; Yoshiaki Ishigatsubo
Administration of an IL-12-encoding DNA plasmid prevents the development of chronic graft-versus-host disease (GVHD).
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4013-7.
1999: Y Asakura; Peter Lundholm; Anne Kjerrström; Reinhold Benthin; E Lucht; Jun Fukushima; S Schwartz; Kenji Okuda; Britta Wahren; Jorma Hinkula
DNA-plasmids of HIV-1 induce systemic and mucosal immune responses.
Biological chemistry 1999;380(3):375-9.
1999: Ke-Qin Xin; Kenji Hamajima; Shin Sasaki; Takashi Tsuji; Setsuko Watabe; Eiichi Okada; Kenji Okuda
IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine.
Vaccine 1999;17(7-8):858-66.
1999: Y Lu; Ke-Qin Xin; Kenji Hamajima; Takashi Tsuji; I Aoki; J Yang; Shin Sasaki; Jun Fukushima; T Yoshimura; S Toda; Eiichi Okada; Kenji Okuda
Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1.
Clinical and experimental immunology 1999;115(2):335-41.
1999: S Sasaki; K Inamura; Kenji Okuda
Genes that induce immunity--DNA vaccines.
Microbiology and immunology 1999;43(3):191-200.
1999: Susumu Kawamoto; S Hattori; S Uchino; M Mishina; Kenji Okuda
Expression of NMDA receptor channel subunit proteins using baculovirus and herpesvirus vectors.
Methods in molecular biology (Clifton, N.J.) 1999;128():19-32.
1998: P Putkonen; M Quesada-Rolander; Ann-Charlotte Boström; S Schwartz; Rigmor Thorstensson; Kenji Okuda; Britta Wahren; Jorma Hinkula
Immune responses but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts.
Virology 1998;250(2):293-301.
1998: Shin Sasaki; Takashi Tsuji; Y Asakura; Jun Fukushima; Kenji Okuda
The search for a potent DNA vaccine against AIDS: the enhancement of immunogenicity by chemical and genetic adjuvants.
Anticancer research 1998;18(5D):3907-15.
1998: Kenji Hamajima; Shin Sasaki; Jun Fukushima; T Kaneko; Ke-Qin Xin; Ichidai Kudoh; Kenji Okuda
Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response.
Clinical immunology and immunopathology 1998;88(2):205-10.
1998: Ke-Qin Xin; Kenji Hamajima; Shin Sasaki; A Honsho; Takashi Tsuji; Norihisa Ishii; X R Cao; Y Lu; Jun Fukushima; Paul Shapshak; Susumu Kawamoto; Kenji Okuda
Intranasal administration of human immunodeficiency virus type-1 (HIV-1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1.
Immunology 1998;94(3):438-44.
1998: Z You; Jun Fukushima; K Tanaka; S Kawamoto; Kenji Okuda
Induction of entry into the stationary growth phase in Pseudomonas aeruginosa by N-acylhomoserine lactone.
FEMS microbiology letters 1998;164(1):99-106.
1998: Shin Sasaki; K Sumino; Kenji Hamajima; Jun Fukushima; Norihisa Ishii; Susumu Kawamoto; H Mohri; C R Kensil; Kenji Okuda
Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes.
Journal of virology 1998;72(6):4931-9.
1998: S Sasaki; Jun Fukushima; Kenji Okuda
[DNA vaccination--current status and future prospect--a new approach for controlling infectious diseases].
Nihon saikingaku zasshi. Japanese journal of bacteriology 1998;53(2):407-24.
1998: Shin Sasaki; Kenji Hamajima; Jun Fukushima; Atsushi Ihata; Norihisa Ishii; Itsuo Gorai; Fumiki Hirahara; H Mohri; Kenji Okuda
Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.
Infection and immunity 1998;66(2):823-6.
1998: Shin Sasaki; Jun Fukushima; Kenji Hamajima; N Ishii; Takashi Tsuji; Ke-Qin Xin; H Mohri; Kenji Okuda
Adjuvant effect of Ubenimex on a DNA vaccine for HIV-1.
Clinical and experimental immunology 1998;111(1):30-5.
1997: Shin Sasaki; Jun Fukushima; H Arai; K I Kusakabe; Kenji Hamajima; Norihisa Ishii; Fumiki Hirahara; Kenji Okuda; Susumu Kawamoto; J M Ruysschaert; M Vandenbranden; B Wahren; K Okuda
Human immunodeficiency virus type-1-specific immune responses induced by DNA vaccination are greatly enhanced by mannan-coated diC14-amidine.
European journal of immunology 1997;27(12):3121-9.
1997: Norihisa Ishii; Jun Fukushima; T Kaneko; E Okada; K Tani; S I Tanaka; Kenji Hamajima; Ke-Qin Xin; Susumu Kawamoto; WC Koff; K Nishioka; T Yasuda; Kenji Okuda
Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1.
AIDS research and human retroviruses 1997;13(16):1421-8.
1997: Y Asakura; Jorma Hinkula; Ann-Charlotte Boström; Jun Fukushima; Kenji Okuda; Britta Wahren
Induction of HIV-1 specific mucosal immune responses by DNA vaccination.
Scandinavian journal of immunology 1997;46(4):326-30.
1997: Eiichi Okada; Shin Sasaki; Norihisa Ishii; I Aoki; T Yasuda; K Nishioka; Jun Fukushima; J Miyazaki; Britta Wahren; Kenji Okuda
Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3638-47.
1997: S Toda; Norihisa Ishii; Eiichi Okada; K I Kusakabe; H Arai; Kenji Hamajima; Itsuo Gorai; K Nishioka; Kenji Okuda
HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody.
Immunology 1997;92(1):111-7.
1997: Shin Sasaki; Takashi Tsuji; Kenji Hamajima; Jun Fukushima; Norihisa Ishii; T Kaneko; Ke-Qin Xin; H Mohri; I Aoki; T Okubo; K Nishioka; Kenji Okuda
Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1.
Infection and immunity 1997;65(9):3520-8.
1997: Kenji Okuda; K O Xin; Takashi Tsuji; Hiroki Bukawa; S Tanaka; WC Koff; K Tani; K Okuda; K Honma; Susumu Kawamoto; Kenji Hamajima; Jun Fukushima
DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity.
Vaccine 1997;15(10):1049-56.
1997: Susumu Kawamoto; S Uchino; Ke-Qin Xin; S Hattori; Kenji Hamajima; Jun Fukushima; Masayoshi Mishina; Kenji Okuda
Arginine-481 mutation abolishes ligand-binding of the AMPA-selective glutamate receptor channel alpha1-subunit.
Brain research. Molecular brain research 1997;47(1-2):339-44.
1997: Jorma Hinkula; C Svanholm; S Schwartz; Peter Lundholm; M Brytting; Gunnel Engström; Reinhold Benthin; H Glaser; Gerd Sutter; B Kohleisen; Volker Erfle; Kenji Okuda; Hans Wigzell; Britta Wahren
Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes.
Journal of virology 1997;71(7):5528-39.
1997: Kenji Hamajima; Jun Fukushima; Hiroki Bukawa; T Kaneko; T Tsuji; Y Asakura; Shin Sasaki; Ke-Qin Xin; Kenji Okuda
Strong augment effect of IL-12 expression plasmid on the induction of HIV-specific cytotoxic T lymphocyte activity by a peptide vaccine candidate.
Clinical immunology and immunopathology 1997;83(2):179-84.
1997: Takashi Tsuji; Kenji Hamajima; Jun Fukushima; Ke-Qin Xin; Norihisa Ishii; I Aoki; Yoshiaki Ishigatsubo; K Tani; Susumu Kawamoto; Y Nitta; J Miyazaki; WC Koff; Takao Okubo; Kenji Okuda
Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):4008-13.
1997: Takashi Tsuji; Kenji Hamajima; Norihisa Ishii; I Aoki; Jun Fukushima; Ke-Qin Xin; Susumu Kawamoto; Shin Sasaki; K Matsunaga; Yoshiaki Ishigatsubo; K Tani; T Okubo; Kenji Okuda
Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen.
European journal of immunology 1997;27(3):782-7.
1997: S Uchino; S Nakajima-Iijima; Kenji Okuda; M Mishina; Susumu Kawamoto
Analysis of the glycine binding domain of the NMDA receptor channel zeta 1 subunit.
Neuroreport 1997;8(2):445-9.
1997: Jun Fukushima; T Ishiwata; Z You; T Ishii; T Shigematsu; M Kurata; S Chikumaru-Fujita; Barrie W Bycroft; GS Stewart; S Kawamoto; K Morihara; P Williams; Kenji Okuda
Dissection of the promoter/operator region and evaluation of N-acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa.
FEMS microbiology letters 1997;146(2):311-8.
1997: Norihisa Ishii; Y Sugita; H Nakajima; Hiroki Bukawa; Y Asakura; Kenji Okuda
Genetic control of immune responses to HIV-1 env DNA vaccine.
Microbiology and immunology 1997;41(5):421-5.
1997: Takashi Tsuji; Jun Fukushima; Kenji Hamajima; Norihisa Ishii; I Aoki; Hiroki Bukawa; Yoshiaki Ishigatsubo; K Tani; T Okubo; M E Dorf; Kenji Okuda
HIV-1-specific cell-mediated immunity is enhanced by co-inoculation of TCA3 expression plasmid with DNA vaccine.
Immunology 1997;90(1):1-6.
1996: Y Asakura; Kenji Hamajima; Jun Fukushima; Hiroshi Mohri; T Okubo; Kenji Okuda
Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine.
American journal of hematology 1996;53(2):116-7.
1996: Z You; Jun Fukushima; T Ishiwata; B Chang; M Kurata; Susumu Kawamoto; P Williams; Kenji Okuda
Purification and characterization of LasR as a DNA-binding protein.
FEMS microbiology letters 1996;142(2-3):301-7.
1996: Tadashi Yamakawa; S i Tanaka; Y Yamakawa; F Isoda; Susumu Kawamoto; Jun Fukushima; Mutsuhiko Minami; Kenji Okuda; Hisahiko Sekihara
Genetic control of in vivo tumor necrosis factor production in mice.
Clinical immunology and immunopathology 1996;79(3):256-62.
1996: Paul Shapshak; Keith A Crandall; Ke-Qin Xin; Karl Goodkin; Robert Fujimura; Walter G Bradley; Clyde B McCoy; I Nagano; M Yoshioka; Carol K Petito; N C Sun; A K Srivastava; NL Weatherby; R Stewart; Silvia Delgado; A Matthews; Richard Douyon; Kenji Okuda; J Yang; B T Zhangl; X R Cao; S Shatkovsky; J B Fernandez; S M Shah; J Perper
HIV-1 neuropathogenesis and abused drugs: current reviews, problems, and solutions.
Advances in experimental medicine and biology 1996;402():171-86.
1995: Kenji Hamajima; Hiroki Bukawa; Jun Fukushima; Susumu Kawamoto; T Kaneko; K Sekigawa; S i Tanaka; M Tsukuda; Kenji Okuda
A macromolecular multicomponent peptide vaccine prepared using the glutaraldehyde conjugation method with strong immunogenicity for HIV-1.
Clinical immunology and immunopathology 1995;77(3):374-9.
1995: Ke-Qin Xin; Paul Shapshak; S Kawamoto; I Nagano; Clyde B McCoy; Kenji Okuda
Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida.
AIDS research and human retroviruses 1995;11(9):1139-41.
1995: Kenji Okuda; Hiroki Bukawa; Kenji Hamajima; Susumu Kawamoto; K Sekigawa; Y Yamada; S i Tanaka; N Ishi; I Aoki; M Nakamura
Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.
AIDS research and human retroviruses 1995;11(8):933-43.
1995: Hiroki Bukawa; K Sekigawa; Kenji Hamajima; Jun Fukushima; Y Yamada; H Kiyono; Kenji Okuda
Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate.
Nature medicine 1995;1(7):681-5.
1995: Susumu Kawamoto; S Uchino; S Hattori; Kenji Hamajima; M Mishina; S Nakajima-Iijima; Kenji Okuda
Expression and characterization of the zeta 1 subunit of the N-methyl-D-aspartate (NMDA) receptor channel in a baculovirus system.
Brain research. Molecular brain research 1995;30(1):137-48.
1995: Tadashi Yamakawa; S i Tanaka; Y Yamakawa; Y Kiuchi; F Isoda; Susumu Kawamoto; Kenji Okuda; Hisahiko Sekihara
Augmented production of tumor necrosis factor-alpha in obese mice.
Clinical immunology and immunopathology 1995;75(1):51-6.
1995: Susumu Kawamoto; S Hattori; K Sakimura; M Mishina; Kenji Okuda
N-linked glycosylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-selective glutamate receptor channel alpha 2 subunit is essential for the acquisition of ligand-binding activity.
Journal of neurochemistry 1995;64(3):1258-66.
1995: T Ando; T Kato; K Ishihara; Hideki Ogiuchi; Kenji Okuda
Heat shock proteins in the human periodontal disease process.
Microbiology and immunology 1995;39(5):321-7.
1995: Hiroki Bukawa; Jun Fukushima; Kenji Hamajima; M Kimura; Takashi Tsuji; Ke-Qin Xin; Kenji Okuda
Antibody responses raised against a conformational V3 loop peptide of HIV-1.
Microbiology and immunology 1995;39(8):607-14.
1994: S Hattori; Kenji Okuda; Kenji Hamajima; K Sakimura; M Mishina; Susumu Kawamoto
Expression and characterization of the alpha 2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptor channel in a baculovirus system.
Brain research 1994;666(1):43-52.
1994: Jun Fukushima; T Ishiwata; M Kurata; Z You; Kenji Okuda
Intracellular receptor-type transcription factor, LasR, contains a highly conserved amphipathic region which precedes the putative helix-turn-helix DNA binding motif.
Nucleic acids research 1994;22(18):3706-7.
1994: Atsuhisa Ueda; Kenji Okuda; S Ohno; Akira Shirai; T Igarashi; K Matsunaga; Jun Fukushima; Susumu Kawamoto; Yoshiaki Ishigatsubo; T Okubo
NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2052-63.
1994: Susumu Kawamoto; S Hattori; I Oiji; Kenji Hamajima; M Mishina; Kenji Okuda
Ligand-binding properties and N-glycosylation of alpha 1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate(AMPA)-selective glutamate receptor channel expressed in a baculovirus system.
European journal of biochemistry / FEBS 1994;223(2):665-73.
1994: Atsuhisa Ueda; Susumu Kawamoto; T Igarashi; Yoshiaki Ishigatsubo; K Tani; T Okubo; Kenji Okuda
Human monocyte chemoattractant protein-1 expressed in a baculovirus system.
Gene 1994;140(2):267-72.
1994: T Ishii; Jun Fukushima; S Fujita; T Shigematsu; N Ando; T Ishiwata; M Kurata; Susumu Kawamoto; K Morihara; Kenji Okuda
Elastase gene expression in non-elastase-producing Pseudomonas aeruginosa strains using novel shuttle vector systems.
FEMS microbiology letters 1994;116(3):307-13.
1994: Kenji Okuda; Hiroki Bukawa; Susumu Kawamoto; M Imai; T Saito; P Phanuphak; Kenji Hamajima
A serologic analysis and the amino acid sequence of the V3 region of human immunodeficiency virus from carriers in Bangkok.
The Journal of infectious diseases 1994;169(1):227-8.
1993: Susumu Kawamoto; S Hattori; I Oiji; A Ueda; Jun Fukushima; K Sakimura; M Mishina; Kenji Okuda
Expression of the alpha 1 and alpha 2 subunits of the AMPA-selective glutamate receptor channel in insect cells using a baculovirus vector.
Annals of the New York Academy of Sciences 1993;707():460-2.
1993: Kenji Okuda; T Kaneko; T Yamakawa; S i Tanaka; T Shigematsu; A Yamamoto; Kenji Hamajima; K Nakajima; Susumu Kawamoto; P Phanuphak
Strong immunogenicity of a multicomponent peptide vaccine developed with the branched lysine oligopeptide method for human immunodeficiency virus infection.
Journal of molecular recognition : JMR 1993;6(3):101-9.
1993: Susumu Kawamoto; Y Amaya; S Hattori; Y Miyagi; H Onishi; Kenji Okuda
Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control.
Biochimica et biophysica acta 1993;1173(1):111-4.
1993: Susumu Kawamoto; Y Shibano; Jun Fukushima; Norihisa Ishii; K Morihara; Kenji Okuda
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.
Infection and immunity 1993;61(4):1400-5.
1993: M Nishio; Y Isobe; H Hatano; S Ohno; Kenji Okuda; Norihisa Ishii
The genetic effect of engineered vaccine on Pseudomonas aeruginosa infection in mice.
Immunogenetics 1993;38(4):280-2.
1993: Kenji Okuda; T Kaneko; T Yamakawa; S i Tanaka; Kenji Hamajima; T Shigematsu; A Yamamato; Susumu Kawamoto
Strong synergistic effects of multicomponent vaccine for human immunodeficiency virus infection.
Journal of clinical & laboratory immunology 1993;40(3):97-113.
1992: H Takeuchi; Y Shibano; K Morihara; Jun Fukushima; S Inami; B Keil; A M Gilles; Susumu Kawamoto; Kenji Okuda
Structural gene and complete amino acid sequence of Vibrio alginolyticus collagenase.
The Biochemical journal 1992;281 ( Pt 3)():703-8.
1991: Susumu Kawamoto; H Onishi; S Hattori; Y Miyagi; Y Amaya; M Mishina; Kenji Okuda
Functional expression of the alpha 1 subunit of the AMPA-selective glutamate receptor channel, using a baculovirus system.
Biochemical and biophysical research communications 1991;181(2):756-63.
1991: E Tanaka; Susumu Kawamoto; Jun Fukushima; Kenji Hamajima; H Onishi; Y Miyagi; S Inami; K Morihara; Kenji Okuda
Detection of elastase production in Escherichia coli with the elastase structural gene from several non-elastase-producing strains of Pseudomonas aeruginosa.
Journal of bacteriology 1991;173(19):6153-8.
1991: Jun Fukushima; S Inami; Kenji Okuda
[Aspects on the molecular genetics of Pseudomonas aeruginosa; elastase, alkaline protease and other pathogenic factors].
Nihon rinsho. Japanese journal of clinical medicine 1991;49(10):2220-6.
1990: Kenji Okuda; K Morihara; Y Atsumi; H Takeuchi; Susumu Kawamoto; H Kawasaki; K Suzuki; Jun Fukushima
Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455.
Infection and immunity 1990;58(12):4083-8.
1990: S i Tanaka; S Nakajima; S Inoue; Y Takamura; I Aoki; Kenji Okuda
Genetic control by I-A subregion in H-2 complex of incidence of streptozocin-induced autoimmune diabetes in mice.
Diabetes 1990;39(10):1298-304.
1990: Jun Fukushima; H Takeuchi; E Tanaka; Kenji Hamajima; Y Sato; Susumu Kawamoto; K Morihara; B Keil; Kenji Okuda
Molecular cloning and partial DNA sequencing of the collagenase gene of Vibrio alginolyticus.
Microbiology and immunology 1990;34(12):977-84.
1989: Y Atsumi; S Yamamoto; K Morihara; Jun Fukushima; H Takeuchi; N Mizuki; Susumu Kawamoto; Kenji Okuda
Cloning and expression of the alkaline proteinase gene from Pseudomonas aeruginosa IFO 3455.
Journal of bacteriology 1989;171(9):5173-5.
1989: Susumu Kawamoto; T Kaneko; N Mizuki; A Ohsuga; Jun Fukushima; Y Amaya; M Mori; Kenji Okuda
Molecular cloning and nucleotide sequence of rat brain argininosuccinate lyase cDNA with an extremely long 5'-untranslated sequence: evidence for the identity of the brain and liver enzymes.
Brain research. Molecular brain research 1989;5(3):235-41.
1989: Jun Fukushima; S Yamamoto; K Morihara; Y Atsumi; H Takeuchi; Susumu Kawamoto; Kenji Okuda
Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase.
Journal of bacteriology 1989;171(3):1698-704.
1989: N Hikawa; H Horie; Tadashi Kawakami; Kenji Okuda; Toshifumi Takenaka
Introduction of macromolecules into primary cultured neuronal cells by fusion with erythrocyte ghosts.
Brain research 1989;481(1):162-4.
1988: Norihisa Ishii; I Aoki; T Ishii; N Mizuki; Kenji Okuda; Hiroshi Nakajima
Suppressor T cells in mice made unresponsive to skin allografts.
The Journal of investigative dermatology 1988;91(4):333-5.
1988: Jun Fukushima; K Tani; Y Atsumi; Kenji Hamajima; Susumu Kawamoto; Kenji Okuda
Trans-activation of class II (I-A alpha) gene by I-A beta gene transfection using bovine papilloma virus as a shuttle vector system.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):302-7.
1988: S Yamamoto; Jun Fukushima; Y Atsumi; H Takeuchi; Susumu Kawamoto; Kenji Okuda; K Morihara
Cloning and characterization of elastase structural gene from Pseudomonas aeruginosa IFO 3455.
Biochemical and biophysical research communications 1988;152(3):1117-22.
1988: Shunsuke Yanoma; I Aoki; Norihisa Ishii; K Tani; Chella S David; Kenji Okuda
The role of autoreactive T-cell hybridomas from autoimmune model mice.
Immunology 1988;64(1):113-9.
1988: Norihisa Ishii; S Ichiyama; T Ishii; I Aoki; Kenji Okuda; Hiroshi Nakajima
Genetic control of delayed-type hypersensitivity to D-penicillamine antigen.
International archives of allergy and applied immunology 1988;85(2):150-3.
1987: Norihisa Ishii; H Kawaguchi; I Aoki; T Takahashi; Kenji Okuda; Hiroshi Nakajima
Delayed-type hypersensitivity to allogeneic mouse epidermal cell antigens. III. Analysis of suppressor cells.
Experimental and clinical immunogenetics 1987;4(1):48-55.