Kenji Okuda

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Abe Shinya; Okuda Kenji; Ura Takehiro; Kondo Asami; Yoshida Atsushi; Yoshizaki Shinji; Mizuguchi Hiroyuki; Klinman Dennis; Shimada Masaru
Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5.
Kobiyama Kouji; Takeshita Fumihiko; Ishii Ken J; Koyama Shohei; Aoshi Taiki; Akira Shizuo; Sakaue-Sawano Asako; Miyawaki Atsushi; Yamanaka Yuko; Hirano Hisashi; Suzuki Koichi; Okuda Kenji
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Ura Takehiro; Yoshida Atsushi; Xin Ke-Qin; Yoshizaki Shinji; Yashima Sayaka; Abe Shinya; Mizuguchi Hiroyuki; Okuda Kenji
Designed recombinant adenovirus type 5 vector induced envelope-specific CD8(+) cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1.

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All Publications

2009: Abe Shinya; Okuda Kenji; Ura Takehiro; Kondo Asami; Yoshida Atsushi; Yoshizaki Shinji; Mizuguchi Hiroyuki; Klinman Dennis; Shimada Masaru
Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5.
The journal of gene medicine 2009;11(7):570-9.
2009: Kobiyama Kouji; Takeshita Fumihiko; Ishii Ken J; Koyama Shohei; Aoshi Taiki; Akira Shizuo; Sakaue-Sawano Asako; Miyawaki Atsushi; Yamanaka Yuko; Hirano Hisashi; Suzuki Koichi; Okuda Kenji
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1593-601.
2009: Ura Takehiro; Yoshida Atsushi; Xin Ke-Qin; Yoshizaki Shinji; Yashima Sayaka; Abe Shinya; Mizuguchi Hiroyuki; Okuda Kenji
Designed recombinant adenovirus type 5 vector induced envelope-specific CD8(+) cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1.
The journal of gene medicine 2009;11(2):139-49.
2009: Shimada M; Wang H-B; Kondo A; Xu X-P; Yoshida A; Shinoda K; Ura T; Mizuguchi H; Klinman D; Luo J-L; Bai H; Okuda K
Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV infection of rhesus monkeys undergoing antiretroviral therapy.
Gene therapy 2009;16(2):218-28.
2008: Takeshita Fumihiko; Kobiyama Kouji; Miyawaki Atsushi; Jounai Nao; Okuda Kenji
The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling.
Autophagy 2008;4(1):67-9.
2007: Jounai Nao; Takeshita Fumihiko; Kobiyama Kouji; Sawano Asako; Miyawaki Atsushi; Xin Ke-Qin; Ishii Ken J; Kawai Taro; Akira Shizuo; Suzuki Koichi; Okuda Kenji
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14050-5.
2007: Saha Sukumar; Takeshita Fumihiko; Matsuda Tomoko; Jounai Nao; Kobiyama Kouji; Matsumoto Tetsuya; Sasaki Shin; Yoshida Atsushi; Xin Ke-Qin; Klinman Dennis M; Uematsu Satoshi; Ishii Ken J; Akira Shizuo; Okuda Kenji
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1147-54.
2007: Kobayashi Nobuaki; Yang Jun; Ueda Atsuhisa; Suzuki Takeyuki; Tomaru Kouji; Takeno Mitsuhiro; Okuda Kenji; Ishigatsubo Yoshiaki
RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex.
Gene 2007;396(2):236-47.
2007: Xin Ke-Qin; Sekimoto Yuka; Takahashi Toru; Mizuguchi Hiroyuki; Ichino Motohide; Yoshida Atsushi; Okuda Kenji
Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV.
Vaccine 2007;25(19):3809-15.
2007: Watanabe-Kaneko Keiko; Sonoda Tomoko; Miyagi Yohei; Yamashita Tetsuji; Okuda Kenji; Kawamoto Susumu
The synaptic scaffolding protein Delphilin interacts with monocarboxylate transporter 2.
Neuroreport 2007;18(5):489-93.
2007: Takeshita Fumihiko; Takase Keiko; Tozuka Miyuki; Saha Sukumar; Okuda Kenji; Ishii Norihisa; Sasaki Shin
Muscle creatine kinase/SV40 hybrid promoter for muscle-targeted long-term transgene expression.
International journal of molecular medicine 2007;19(2):309-15.
2007: Matsui Kiyohiko; Saha Sukumar; Saitoh Masaaki; Mizuki Nobuhisa; Itoh Norihiko; Okada Eiichi; Yoshida Atsushi; Xin Ke-Qin; Nishio Osamu; Okuda Kenji
Isolation and identification of adenovirus from conjunctival scrapings over a two-year period (between 2001 and 2003) in Yokohama, Japan.
Journal of medical virology 2007;79(2):200-5.
2007: Kojima Yoshitsugu; Jounai Nao; Takeshita Fumihiko; Nakazawa Masatoshi; Okuda Kentaro; Watabe Setsuko; Xin Ke-Qin; Okuda Kenji
The degree of apoptosis as an immunostimulant for a DNA vaccine against HIV-1 infection.
Vaccine 2007;25(3):438-45.
2006: Xin Ke-Qin; Mizukami Hiroaki; Urabe Masashi; Toda Yoshihiko; Shinoda Kaori; Yoshida Atsushi; Oomura Kenji; Kojima Yoshitsugu; Ichino Motohide; Klinman Dennis; Ozawa Keiya; Okuda Kenji
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.
Journal of virology 2006;80(24):11899-910.
2006: Sonoda Tomoko; Mochizuki Chieko; Yamashita Tetsuji; Watanabe-Kaneko Keiko; Miyagi Yohei; Shigeri Yasushi; Yazama Futoshi; Okuda Kenji; Kawamoto Susumu
Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.
Biochemical and biophysical research communications 2006;350(3):748-52.
2006: Ihata Atsushi; Watabe Setsuko; Okuda Kenji
[DNA vaccination]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(10):1865-9.
2006: Saha Sukumar; Yoshida Shinsuke; Ohba Kenji; Matsui Kiyohiko; Matsuda Tomoko; Takeshita Fumihiko; Umeda Kazunori; Tamura Yuichi; Okuda Kentaro; Klinman Dennis; Xin Ke-Qin; Okuda Kenji
A fused gene of nucleoprotein (NP) and herpes simplex virus genes (VP22) induces highly protective immunity against different subtypes of influenza virus.
Virology 2006;354(1):48-57.
2006: Saha Sukumar; Takeshita Fumihiko; Sasaki Shin; Matsuda Tomoko; Tanaka Toshiyuki; Tozuka Miyuki; Takase Keiko; Matsumoto Tetsuya; Okuda Katsuji; Ishii Norihisa; Yamaguchi Keizo; Klinman Dennis M; Xin Ke-Qin; Okuda Kenji
Multivalent DNA vaccine protects mice against pulmonary infection caused by Pseudomonas aeruginosa.
Vaccine 2006;24(37-39):6240-9.
2006: Sasaki Shin; Smith James M; Takase Keiko; Okuda Kenji; Ishii Norihisa; Takeshita Fumihiko
Activator protein 1-mediated transcriptional regulation strategy sustains long-term expression of a xenogeneic gene product in vivo: an implication for gene therapy targeting congenital protein deficiencies.
International journal of molecular medicine 2006;18(2):289-97.
2006: Okada Eiichi; Matsuda Tomoko; Yokoyama Tetsuro; Okuda Kenji
Lysozyme penetration in group IV soft contact lenses.
Eye & contact lens 2006;32(4):174-7.
2006: Takeshita Fumihiko; Tanaka Toshiyuki; Matsuda Tomoko; Tozuka Miyuki; Kobiyama Kouji; Saha Sukumar; Matsui Kiyohiko; Ishii Ken J; Coban Cevayir; Akira Shizuo; Ishii Norihisa; Suzuki Koichi; Klinman Dennis M; Okuda Kenji; Sasaki Shin
Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity.
Journal of virology 2006;80(13):6218-24.
2006: Shinoda Kaori; Xin Ke-Qin; Kojima Yoshitsugu; Saha Sukumar; Okuda Kentaro; Okuda Kenji
Robust HIV-specific immune responses were induced by DNA vaccine prime followed by attenuated recombinant vaccinia virus (LC16m8 strain) boost.
Clinical immunology (Orlando, Fla.) 2006;119(1):32-7.
2006: Shinoda Kaori; Xin Ke-Qin; Okuda Kenji
A modified HIV challenge assay in mice by using luciferase-expressing vaccinia virus.
Vaccine 2006;24(15):2751-4.
2006: Matsuda Reikei; Boström Ann-Charlotte; Fredriksson Malin; Fredriksson Eva-Lena; Bratt Göran; Hejdeman Bo; Sandström Eric; Okuda Kenji; Wahren Britta
Human immunodeficiency virus-type 1 specific cellular immunity in chronic infected patients on prolonged highly active antiretroviral treatment and on structured treatment interruption.
Microbiology and immunology 2006;50(8):629-35.
2005: Hiraide Atsuo; Yokoo Naoki; Xin Ke-Qin; Okuda Kenji; Mizukami Hiroaki; Ozawa Keiya; Saito Tomoyuki
Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.
Human gene therapy 2005;16(12):1413-21.
2005: Takakura Momoko; Takeshita Fumihiko; Aihara Michiko; Xin Ke-Qin; Ichino Motohide; Okuda Kenji; Ikezawa Zenro
Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of atopic dermatitis-like skin lesion in some NC/Nga mice.
The Journal of investigative dermatology 2005;125(6):1156-62.
2005: Xin K-Q; Jounai N; Someya K; Honma K; Mizuguchi H; Naganawa S; Kitamura K; Hayakawa T; Saha S; Takeshita F; Okuda K; Honda M; Klinman D M; Okuda K
Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV.
Gene therapy 2005;12(24):1769-77.
2005: Xin K-Q; Jounai N; Someya K; Honma K; Mizuguchi H; Naganawa S; Kitamura K; Hayakawa T; Saha S; Takeshita F; Okuda K; Honda M; Klinman D M; Okuda K
Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV.
Gene therapy 2005;12(24):1769-77.
2005: Yamashita Tetsuji; Miyagi Yohei; Ono Michio; Ito Hiroaki; Watanabe Keiko; Sonoda Tomoko; Tsuzuki Keisuke; Ozawa Seiji; Aoki Ichiro; Okuda Kenji; Mishina Masayoshi; Kawamoto Susumu
Identification and characterization of a novel Delphilin variant with an alternative N-terminus.
Brain research. Molecular brain research 2005;141(1):83-94.
2005: Takeshita Fumihiko; Ishii Ken J; Kobiyama Kouji; Kojima Yoshitsugu; Coban Cevayir; Sasaki Shin; Ishii Norihisa; Klinman Dennis M; Okuda Kenji; Akira Shizuo; Suzuki Koichi
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
European journal of immunology 2005;35(8):2477-85.
2005: Shen Yan; Ichino Motohide; Nakazawa Masatoshi; Ikejima Takashi; Kojima Yoshitsugu; Okuda Kenji; Minami Mutsuhiko
Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma.
Journal of autoimmunity 2005;24(3):183-90.
2005: Yokoo Naoki; Saito Tomoyuki; Uesugi Masaaki; Kobayashi Naomi; Xin Ke-Qin; Okuda Kenji; Mizukami Hiroaki; Ozawa Keiya; Koshino Tomihisa
Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.
Arthritis and rheumatism 2005;52(1):164-70.
2005: Ozaki Tomomi; Yauchi Masaomi; Xin Ke-Qin; Hirahara Fumiki; Okuda Kenji
Cross-reactive protection against influenza A virus by a topically applied DNA vaccine encoding M gene with adjuvant.
Viral immunology 2005;18(2):373-80.
2004: Devito Claudia; Zuber Bartek; Schröder Ulf; Benthin Reinhold; Okuda Kenji; Broliden Kristina; Wahren Britta; Hinkula Jorma
Intranasal HIV-1-gp160-DNA/gp41 peptide prime-boost immunization regimen in mice results in long-term HIV-1 neutralizing humoral mucosal and systemic immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):7078-89.
2004: Shinoda Kaori; Xin Ke-Qin; Jounai Nao; Kojima Yoshitsugu; Tamura Yuichi; Okada Eiichi; Kawamoto Susumu; Okuda Katsuji; Klinman Dennis; Okuda Kenji
Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice.
Vaccine 2004;22(27-28):3676-90.
2004: Hinkula Jorma; Rollman Erik; Lundholm Peter; Benthin Reinhold; Okuda Kenji; Wahren Britta
Genetic immunization with multiple HIV-1 genes provides protection against HIV-1/MuLV pseudovirus challenge in vivo.
Cells, tissues, organs 2004;177(3):169-84.
2003: Yamakawa Tadashi; Tanaka Shun-ichi; Kamei Junzo; Kadonosono Kazuaki; Okuda Kenji
Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.
European journal of pharmacology 2003;478(1):39-46.
2003: Jounai Nao; Okuda Kenji; Kojima Yoshitsugu; Toda Yoshihiko; Hamajima Kenji; Ohba Kenji; Klinman Dennis; Xin Ke-Qin
Contribution of the rev gene to the immunogenicity of DNA vaccines targeting the envelope glycoprotein of HIV.
The journal of gene medicine 2003;5(7):609-17.
2003: Xin Ke-Qin; Hoshino Yuka; Toda Yoshihiko; Igimi Shizunobu; Kojima Yoshitsugu; Jounai Nao; Ohba Kenji; Kushiro Akira; Kiwaki Mayumi; Hamajima Kenji; Klinman Dennis; Okuda Kenji
Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env.
Blood 2003;102(1):223-8.
2003: Xin Ke-Qin; Ooki Takaaki; Jounai Nao; Mizukami Hiroaki; Hamajima Kenji; Kojima Yoshitsugu; Ohba Kenji; Toda Yoshihiko; Hirai Syu-Ichi; Klinman Dennis M; Ozawa Keiya; Okuda Kenji
A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV.
The journal of gene medicine 2003;5(5):438-45.
2003: Hamajima Kenji; Kojima Yoshizumi; Matsui Kiyohiko; Toda Yoshihiko; Jounai Nao; Ozaki Tomomi; Xin Ke-Qin; Strong Peter; Okuda Kenji
Chitin Micro-Particles (CMP): a useful adjuvant for inducing viral specific immunity when delivered intranasally with an HIV-DNA vaccine.
Viral immunology 2003;16(4):541-7.
2003: Yamakawa Tadashi; Tanaka Shun-ichi; Kamei Junzo; Kadonosono Kazuaki; Okuda Kenji
Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2.
Journal of atherosclerosis and thrombosis 2003;10(1):37-42.
2002: Murata Hidetoshi; Tajima Nobuyoshi; Nagashima Yoji; Yao Masahiro; Baba Masaya; Goto Masayuki; Kawamoto Susumu; Yamamoto Isao; Okuda Kenji; Kanno Hiroshi
Von Hippel-Lindau tumor suppressor protein transforms human neuroblastoma cells into functional neuron-like cells.
Cancer research 2002;62(23):7004-11.
2002: Senuma Akiko; Hagiwara Eri; Nagahama Kiyotaka; Okuda Kenji; Nakamura Mitsuyuki; Fukumoto Natsuko; Shirai Akira; Tani Kenji; Ishigatsubo Yoshiaki
Therapeutic effect of CpG motifs on the development of chronic graft-versus-host disease in mice.
Cytokine 2002;20(1):23-9.
2002: Kobayashi Naomi; Koshino Tomihisa; Uesugi Masaaki; Yokoo Naoki; Xin Ke-Qin; Okuda Kenji; Mizukami Hiroaki; Ozawa Keiya; Saito Tomoyuki
Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair.
The Journal of rheumatology 2002;29(10):2176-80.
2002: Xin Ke-Qin; Ooki Takaaki; Mizukami Hiroaki; Hamajima Kenji; Okudela Koji; Hashimoto Kumiko; Kojima Yoshitsugu; Jounai Nao; Kumamoto Yasuko; Sasaki Shin; Klinman Dennis; Ozawa Keiya; Okuda Kenji
Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses.
Human gene therapy 2002;13(13):1571-81.
2002: Kojima Yoshitsugu; Xin Ke-Qin; Ooki Takaaki; Hamajima Kenji; Oikawa Tomohiro; Shinoda Kaori; Ozaki Tomomi; Hoshino Yuka; Jounai Nao; Nakazawa Masatoshi; Klinman Dennis; Okuda Kenji
Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine.
Vaccine 2002;20(23-24):2857-65.
2002: Miyagi Yohei; Yamashita Tetsuji; Fukaya Masahiro; Sonoda Tomoko; Okuno Toshiaki; Yamada Kazuyuki; Watanabe Masahiko; Nagashima Yoji; Aoki Ichiro; Okuda Kenji; Mishina Masayoshi; Kawamoto Susumu
Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):803-14.
2002: Hamajima Kenji; Hoshino Yuka; Xin Ke-Qin; Hayashi Futaba; Tadokoro Kazuyuki; Okuda Kenji
Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine.
Clinical immunology (Orlando, Fla.) 2002;102(1):12-8.
2002: Saito Tomoyuki; Takeuchi Ryohei; Hirakawa Kazuo; Nagata Nobuhito; Yoshida Takuji; Koshino Tomihisa; Okuda Kenji; Takema Morio; Hori Toshihiko
Slow-releasing potential of vancomycin-loaded porous hydroxyapatite blocks implanted into MRSA osteomyelitis.
Journal of biomedical materials research 2002;63(3):245-51.
2001: Okuda K; Xin K Q; Haruki A; Kawamoto S; Kojima Y; Hirahara F; Okada H; Klinman D; Hamajima K
Transplacental genetic immunization after intravenous delivery of plasmid DNA to pregnant mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5478-84.
2001: Liu L J; Watabe S; Yang J; Hamajima K; Ishii N; Hagiwara E; Onari K; Xin K Q; Okuda K
Topical application of HIV DNA vaccine with cytokine-expression plasmids induces strong antigen-specific immune responses.
Vaccine 2001;20(1-2):42-8.
2001: Watabe S; Xin K Q; Ihata A; Liu L J; Honsho A; Aoki I; Hamajima K; Wahren B; Okuda K
Protection against influenza virus challenge by topical application of influenza DNA vaccine.
Vaccine 2001;19(31):4434-44.
2001: Yoshida T; Okuda K; Xin K Q; Tadokoro K; Fukushima J; Toda S; Hagiwara E; Hamajima K; Koshino T; Saito T
Activation of HIV-1-specific immune responses to an HIV-1 vaccine constructed from a replication-defective adenovirus vector using various combinations of immunization protocols.
Clinical and experimental immunology 2001;124(3):445-52.
2001: Xin K Q; Urabe M; Yang J; Nomiyama K; Mizukami H; Hamajima K; Nomiyama H; Saito T; Imai M; Monahan J; Okuda K; Ozawa K; Okuda K
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus.
Human gene therapy 2001;12(9):1047-61.
2001: Xin K Q; Urabe M; Yang J; Nomiyama K; Mizukami H; Hamajima K; Nomiyama H; Saito T; Imai M; Monahan J; Okuda K; Ozawa K; Okuda K
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus.
Human gene therapy 2001;12(9):1047-61.
2001: Okuda K; Ihata A; Watabe S; Okada E; Yamakawa T; Hamajima K; Yang J; Ishii N; Nakazawa M; Okuda K; Ohnari K; Nakajima K; Xin K Q
Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene.
Vaccine 2001;19(27):3681-91.
2001: Okuda K; Ihata A; Watabe S; Okada E; Yamakawa T; Hamajima K; Yang J; Ishii N; Nakazawa M; Okuda K; Ohnari K; Nakajima K; Xin K Q
Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene.
Vaccine 2001;19(27):3681-91.
2001: Ara Y; Saito T; Takagi T; Hagiwara E; Miyagi Y; Sugiyama M; Kawamoto S; Ishii N; Yoshida T; Hanashi D; Koshino T; Okada H; Okuda K
Zymosan enhances the immune response to DNA vaccine for human immunodeficiency virus type-1 through the activation of complement system.
Immunology 2001;103(1):98-105.
2001: Tsuji-Yamada J; Nakazawa M; Takahashi K; Iijima K; Hattori S; Okuda K; Minami M; Ikezawa Z; Sasaki T
Effect of IL-12 encoding plasmid administration on tight-skin mouse.
Biochemical and biophysical research communications 2001;280(3):707-12.
2001: Shigematsu T; Fukushima J; Oyama M; Tsuda M; Kawamoto S; Okuda K
Iron-Mediated regulation of alkaline proteinase production in Pseudomonas aeruginosa.
Microbiology and immunology 2001;45(8):579-90.
2001: Tadokoro K; Koizumi Y; Miyagi Y; Kojima Y; Kawamoto S; Hamajima K; Okuda K; Tanaka S; Onari K; Wahren B; Aoki I; Okuda K
Rapid and wide-reaching delivery of HIV-1 env DNA vaccine by intranasal administration.
Viral immunology 2001;14(2):159-67.
2001: Tadokoro K; Koizumi Y; Miyagi Y; Kojima Y; Kawamoto S; Hamajima K; Okuda K; Tanaka S; Onari K; Wahren B; Aoki I; Okuda K
Rapid and wide-reaching delivery of HIV-1 env DNA vaccine by intranasal administration.
Viral immunology 2001;14(2):159-67.
2000: Hagiwara E; Okubo T; Aoki I; Ohno S; Tsuji T; Ihata A; Ueda A; Shirai A; Okuda K; Miyazaki J; Ishigatsubo Y
IL-12-encoding plasmid has a beneficial effect on spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.
Cytokine 2000;12(7):1035-41.
2000: Arai H; Xin K Q; Hamajima K; Lu Y; Watabe S; Takahashi T; Toda S; Okuda K; Kudoh I; Suzuki M; Okuda K
8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine.
Gene therapy 2000;7(8):694-702.
2000: Arai H; Xin K Q; Hamajima K; Lu Y; Watabe S; Takahashi T; Toda S; Okuda K; Kudoh I; Suzuki M; Okuda K
8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine.
Gene therapy 2000;7(8):694-702.
2000: Fukushima J; Inamoto T; Morihara K; Okuda K
[Bacterial intercellular communication and environmental adaptation]
Nippon saikingaku zasshi. Japanese journal of bacteriology 2000;55(1):37-43.
2000: Kato H; Bukawa H; Hagiwara E; Xin K Q; Hamajima K; Kawamoto S; Sugiyama M; Sugiyama M; Noda E; Nishizaki M; Okuda K
Rectal and vaginal immunization with a macromolecular multicomponent peptide vaccine candidate for HIV-1 infection induces HIV-specific protective immune responses.
Vaccine 2000;18(13):1151-60.
2000: Asakura Y; Liu L J; Shono N; Hinkula J; Kjerrström A; Aoki I; Okuda K; Wahren B; Fukushima J
Th1-biased immune responses induced by DNA-based immunizations are mediated via action on professional antigen-presenting cells to up-regulate IL-12 production.
Clinical and experimental immunology 2000;119(1):130-9.
2000: Hamajima K; Xin K Q; Fukushima J; Yang J; Honsho A; Nakazawa M; Yanoma S; Okuda K
HIV-DNA vaccination following transfer of a large number of activated T cells enhances immunoresponses against HIV-1.
Viral immunology 2000;13(1):3-8.
1999: Aoki I; Itoh S; Yokota S; Tanaka S; Ishii N; Okuda K; Minami M; Klinman D M
Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.
Immunology 1999;98(4):519-24.
1999: Ihata A; Watabe S; Sasaki S; Shirai A; Fukushima J; Hamajima K; Inoue J; Okuda K
Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1.
Immunology 1999;98(3):436-42.
1999: Xin K Q; Hamajima K; Hattori S; Cao X R; Kawamoto S; Okuda K
Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.
AIDS research and human retroviruses 1999;15(16):1461-7.
1999: Xin K Q; Lu Y; Hamajima K; Fukushima J; Yang J; Inamura K; Okuda K
Immunization of RANTES expression plasmid with a DNA vaccine enhances HIV-1-specific immunity.
Clinical immunology (Orlando, Fla.) 1999;92(1):90-6.
1999: Okubo T; Hagiwara E; Ohno S; Tsuji T; Ihata A; Ueda A; Shirai A; Aoki I; Okuda K; Miyazaki J; Ishigatsubo Y
Administration of an IL-12-encoding DNA plasmid prevents the development of chronic graft-versus-host disease (GVHD).
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4013-7.
1999: Asakura Y; Lundholm P; Kjerrström A; Benthin R; Lucht E; Fukushima J; Schwartz S; Okuda K; Wahren B; Hinkula J
DNA-plasmids of HIV-1 induce systemic and mucosal immune responses.
Biological chemistry 1999;380(3):375-9.
1999: Xin K Q; Hamajima K; Sasaki S; Tsuji T; Watabe S; Okada E; Okuda K
IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine.
Vaccine 1999;17(7-8):858-66.
1999: Lu Y; Xin K Q; Hamajima K; Tsuji T; Aoki I; Yang J; Sasaki S; Fukushima J; Yoshimura T; Toda S; Okada E; Okuda K
Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1.
Clinical and experimental immunology 1999;115(2):335-41.
1999: Sasaki S; Inamura K; Okuda K
Genes that induce immunity--DNA vaccines.
Microbiology and immunology 1999;43(3):191-200.
1999: Kawamoto S; Hattori S; Uchino S; Mishina M; Okuda K
Expression of NMDA receptor channel subunit proteins using baculovirus and herpesvirus vectors.
Methods in molecular biology (Clifton, N.J.) 1999;128():19-32.
1998: Putkonen P; Quesada-Rolander M; Leandersson A C; Schwartz S; Thorstensson R; Okuda K; Wahren B; Hinkula J
Immune responses but no protection against SHIV by gene-gun delivery of HIV-1 DNA followed by recombinant subunit protein boosts.
Virology 1998;250(2):293-301.
1998: Sasaki S; Tsuji T; Asakura Y; Fukushima J; Okuda K
The search for a potent DNA vaccine against AIDS: the enhancement of immunogenicity by chemical and genetic adjuvants.
Anticancer research 1998;18(5D):3907-15.
1998: Hamajima K; Sasaki S; Fukushima J; Kaneko T; Xin K Q; Kudoh I; Okuda K
Intranasal administration of HIV-DNA vaccine formulated with a polymer, carboxymethylcellulose, augments mucosal antibody production and cell-mediated immune response.
Clinical immunology and immunopathology 1998;88(2):205-10.
1998: Xin K Q; Hamajima K; Sasaki S; Honsho A; Tsuji T; Ishii N; Cao X R; Lu Y; Fukushima J; Shapshak P; Kawamoto S; Okuda K
Intranasal administration of human immunodeficiency virus type-1 (HIV-1) DNA vaccine with interleukin-2 expression plasmid enhances cell-mediated immunity against HIV-1.
Immunology 1998;94(3):438-44.
1998: You Z; Fukushima J; Tanaka K; Kawamoto S; Okuda K
Induction of entry into the stationary growth phase in Pseudomonas aeruginosa by N-acylhomoserine lactone.
FEMS microbiology letters 1998;164(1):99-106.
1998: Sasaki S; Sumino K; Hamajima K; Fukushima J; Ishii N; Kawamoto S; Mohri H; Kensil C R; Okuda K
Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes.
Journal of virology 1998;72(6):4931-9.
1998: Sasaki S; Fukushima J; Okuda K
[DNA vaccination--current status and future prospect--a new approach for controlling infectious diseases]
Nippon saikingaku zasshi. Japanese journal of bacteriology 1998;53(2):407-24.
1998: Sasaki S; Hamajima K; Fukushima J; Ihata A; Ishii N; Gorai I; Hirahara F; Mohri H; Okuda K
Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.
Infection and immunity 1998;66(2):823-6.
1998: Sasaki S; Fukushima J; Hamajima K; Ishii N; Tsuji T; Xin K Q; Mohri H; Okuda K
Adjuvant effect of Ubenimex on a DNA vaccine for HIV-1.
Clinical and experimental immunology 1998;111(1):30-5.
1997: Sasaki S; Fukushima J; Arai H; Kusakabe K I; Hamajima K; Ishii N; Hirahara F; Okuda K; Kawamoto S; Ruysschaert J M; Vandenbranden M; Wahren B; Okuda K
Human immunodeficiency virus type-1-specific immune responses induced by DNA vaccination are greatly enhanced by mannan-coated diC14-amidine.
European journal of immunology 1997;27(12):3121-9.
1997: Sasaki S; Fukushima J; Arai H; Kusakabe K I; Hamajima K; Ishii N; Hirahara F; Okuda K; Kawamoto S; Ruysschaert J M; Vandenbranden M; Wahren B; Okuda K
Human immunodeficiency virus type-1-specific immune responses induced by DNA vaccination are greatly enhanced by mannan-coated diC14-amidine.
European journal of immunology 1997;27(12):3121-9.
1997: Ishii N; Fukushima J; Kaneko T; Okada E; Tani K; Tanaka S I; Hamajima K; Xin K Q; Kawamoto S; Koff W; Nishioka K; Yasuda T; Okuda K
Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1.
AIDS research and human retroviruses 1997;13(16):1421-8.
1997: Asakura Y; Hinkula J; Leandersson A C; Fukushima J; Okuda K; Wahren B
Induction of HIV-1 specific mucosal immune responses by DNA vaccination.
Scandinavian journal of immunology 1997;46(4):326-30.
1997: Okada E; Sasaki S; Ishii N; Aoki I; Yasuda T; Nishioka K; Fukushima J; Miyazaki J; Wahren B; Okuda K
Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3638-47.
1997: Toda S; Ishii N; Okada E; Kusakabe K I; Arai H; Hamajima K; Gorai I; Nishioka K; Okuda K
HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody.
Immunology 1997;92(1):111-7.
1997: Sasaki S; Tsuji T; Hamajima K; Fukushima J; Ishii N; Kaneko T; Xin K Q; Mohri H; Aoki I; Okubo T; Nishioka K; Okuda K
Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1.
Infection and immunity 1997;65(9):3520-8.
1997: Okuda K; Xin K O; Tsuji T; Bukawa H; Tanaka S; Koff W C; Tani K; Okuda K; Honma K; Kawamoto S; Hamajima K; Fukushima J
DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity.
Vaccine 1997;15(10):1049-56.
1997: Okuda K; Xin K O; Tsuji T; Bukawa H; Tanaka S; Koff W C; Tani K; Okuda K; Honma K; Kawamoto S; Hamajima K; Fukushima J
DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity.
Vaccine 1997;15(10):1049-56.
1997: Kawamoto S; Uchino S; Xin K Q; Hattori S; Hamajima K; Fukushima J; Mishina M; Okuda K
Arginine-481 mutation abolishes ligand-binding of the AMPA-selective glutamate receptor channel alpha1-subunit.
Brain research. Molecular brain research 1997;47(1-2):339-44.
1997: Hinkula J; Svanholm C; Schwartz S; Lundholm P; Brytting M; Engström G; Benthin R; Glaser H; Sutter G; Kohleisen B; Erfle V; Okuda K; Wigzell H; Wahren B
Recognition of prominent viral epitopes induced by immunization with human immunodeficiency virus type 1 regulatory genes.
Journal of virology 1997;71(7):5528-39.
1997: Hamajima K; Fukushima J; Bukawa H; Kaneko T; Tsuji T; Asakura Y; Sasaki S; Xin K Q; Okuda K
Strong augment effect of IL-12 expression plasmid on the induction of HIV-specific cytotoxic T lymphocyte activity by a peptide vaccine candidate.
Clinical immunology and immunopathology 1997;83(2):179-84.
1997: Tsuji T; Hamajima K; Fukushima J; Xin K Q; Ishii N; Aoki I; Ishigatsubo Y; Tani K; Kawamoto S; Nitta Y; Miyazaki J; Koff W C; Okubo T; Okuda K
Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):4008-13.
1997: Tsuji T; Hamajima K; Ishii N; Aoki I; Fukushima J; Xin K Q; Kawamoto S; Sasaki S; Matsunaga K; Ishigatsubo Y; Tani K; Okubo T; Okuda K
Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen.
European journal of immunology 1997;27(3):782-7.
1997: Uchino S; Nakajima-Iijima S; Okuda K; Mishina M; Kawamoto S
Analysis of the glycine binding domain of the NMDA receptor channel zeta 1 subunit.
Neuroreport 1997;8(2):445-9.
1997: Tsuji T; Fukushima J; Hamajima K; Ishii N; Aoki I; Bukawa H; Ishigatsubo Y; Tani K; Okubo T; Dorf M E; Okuda K
HIV-1-specific cell-mediated immunity is enhanced by co-inoculation of TCA3 expression plasmid with DNA vaccine.
Immunology 1997;90(1):1-6.
1997: Fukushima J; Ishiwata T; You Z; Ishii T; Shigematsu T; Kurata M; Chikumaru-Fujita S; Bycroft B W; Stewart G S; Kawamoto S; Morihara K; Williams P; Okuda K
Dissection of the promoter/operator region and evaluation of N-acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa.
FEMS microbiology letters 1997;146(2):311-8.
1997: Ishii N; Sugita Y; Nakajima H; Bukawa H; Asakura Y; Okuda K
Genetic control of immune responses to HIV-1 env DNA vaccine.
Microbiology and immunology 1997;41(5):421-5.
1996: Asakura Y; Hamajima K; Fukushima J; Mohri H; Okubo T; Okuda K
Induction of HIV-1 Nef-specific cytotoxic T lymphocytes by Nef-expressing DNA vaccine.
American journal of hematology 1996;53(2):116-7.
1996: You Z; Fukushima J; Ishiwata T; Chang B; Kurata M; Kawamoto S; Williams P; Okuda K
Purification and characterization of LasR as a DNA-binding protein.
FEMS microbiology letters 1996;142(2-3):301-7.
1996: Yamakawa T; Tanaka S I; Yamakawa Y; Isoda F; Kawamoto S; Fukushima J; Minami M; Okuda K; Sekihara H
Genetic control of in vivo tumor necrosis factor production in mice.
Clinical immunology and immunopathology 1996;79(3):256-62.
1996: Shapshak P; Crandall K A; Xin K Q; Goodkin K; Fujimura R K; Bradley W; McCoy C B; Nagano I; Yoshioka M; Petito C; Sun N C; Srivastava A K; Weatherby N; Stewart R; Delgado S; Matthews A; Douyon R; Okuda K; Yang J; Zhangl B T; Cao X R; Shatkovsky S; Fernandez J B; Shah S M; Perper J
HIV-1 neuropathogenesis and abused drugs: current reviews, problems, and solutions.
Advances in experimental medicine and biology 1996;402():171-86.
1995: Hamajima K; Bukawa H; Fukushima J; Kawamoto S; Kaneko T; Sekigawa K; Tanaka S; Tsukuda M; Okuda K
A macromolecular multicomponent peptide vaccine prepared using the glutaraldehyde conjugation method with strong immunogenicity for HIV-1.
Clinical immunology and immunopathology 1995;77(3):374-9.
1995: Xin K Q; Shapshak P; Kawamoto S; Nagano I; McCoy C B; Okuda K
Highly divergent env sequences of HIV-1 B subtype with two novel V3 loop motifs detected in an AIDS patient in Miami, Florida.
AIDS research and human retroviruses 1995;11(9):1139-41.
1995: Okuda K; Bukawa H; Hamajima K; Kawamoto S; Sekigawa K; Yamada Y; Tanaka S; Ishi N; Aoki I; Nakamura M
Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.
AIDS research and human retroviruses 1995;11(8):933-43.
1995: Bukawa H; Sekigawa K; Hamajima K; Fukushima J; Yamada Y; Kiyono H; Okuda K
Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate.
Nature medicine 1995;1(7):681-5.
1995: Kawamoto S; Uchino S; Hattori S; Hamajima K; Mishina M; Nakajima-Iijima S; Okuda K
Expression and characterization of the zeta 1 subunit of the N-methyl-D-aspartate (NMDA) receptor channel in a baculovirus system.
Brain research. Molecular brain research 1995;30(1):137-48.
1995: Yamakawa T; Tanaka S; Yamakawa Y; Kiuchi Y; Isoda F; Kawamoto S; Okuda K; Sekihara H
Augmented production of tumor necrosis factor-alpha in obese mice.
Clinical immunology and immunopathology 1995;75(1):51-6.
1995: Kawamoto S; Hattori S; Sakimura K; Mishina M; Okuda K
N-linked glycosylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-selective glutamate receptor channel alpha 2 subunit is essential for the acquisition of ligand-binding activity.
Journal of neurochemistry 1995;64(3):1258-66.
1995: Ando T; Kato T; Ishihara K; Ogiuchi H; Okuda K
Heat shock proteins in the human periodontal disease process.
Microbiology and immunology 1995;39(5):321-7.
1995: Bukawa H; Fukushima J; Hamajima K; Kimura M; Tsuji T; Xin K Q; Okuda K
Antibody responses raised against a conformational V3 loop peptide of HIV-1.
Microbiology and immunology 1995;39(8):607-14.
1994: Hattori S; Okuda K; Hamajima K; Sakimura K; Mishina M; Kawamoto S
Expression and characterization of the alpha 2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptor channel in a baculovirus system.
Brain research 1994;666(1):43-52.
1994: Ueda A; Okuda K; Ohno S; Shirai A; Igarashi T; Matsunaga K; Fukushima J; Kawamoto S; Ishigatsubo Y; Okubo T
NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2052-63.
1994: Fukushima J; Ishiwata T; Kurata M; You Z; Okuda K
Intracellular receptor-type transcription factor, LasR, contains a highly conserved amphipathic region which precedes the putative helix-turn-helix DNA binding motif.
Nucleic acids research 1994;22(18):3706-7.
1994: Kawamoto S; Hattori S; Oiji I; Hamajima K; Mishina M; Okuda K
Ligand-binding properties and N-glycosylation of alpha 1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate(AMPA)-selective glutamate receptor channel expressed in a baculovirus system.
European journal of biochemistry / FEBS 1994;223(2):665-73.
1994: Ueda A; Kawamoto S; Igarashi T; Ishigatsubo Y; Tani K; Okubo T; Okuda K
Human monocyte chemoattractant protein-1 expressed in a baculovirus system.
Gene 1994;140(2):267-72.
1994: Ishii T; Fukushima J; Fujita S; Shigematsu T; Ando N; Ishiwata T; Kurata M; Kawamoto S; Morihara K; Okuda K
Elastase gene expression in non-elastase-producing Pseudomonas aeruginosa strains using novel shuttle vector systems.
FEMS microbiology letters 1994;116(3):307-13.
1994: Okuda K; Bukawa H; Kawamoto S; Imai M; Saito T; Phanuphak P; Hamajima K
A serologic analysis and the amino acid sequence of the V3 region of human immunodeficiency virus from carriers in Bangkok.
The Journal of infectious diseases 1994;169(1):227-8.
1993: Kawamoto S; Hattori S; Oiji I; Ueda A; Fukushima J; Sakimura K; Mishina M; Okuda K
Expression of the alpha 1 and alpha 2 subunits of the AMPA-selective glutamate receptor channel in insect cells using a baculovirus vector.
Annals of the New York Academy of Sciences 1993;707():460-2.
1993: Okuda K; Kaneko T; Yamakawa T; Tanaka S; Shigematsu T; Yamamoto A; Hamajima K; Nakajima K; Kawamoto S; Phanuphak P
Strong immunogenicity of a multicomponent peptide vaccine developed with the branched lysine oligopeptide method for human immunodeficiency virus infection.
Journal of molecular recognition : JMR 1993;6(3):101-9.
1993: Kawamoto S; Amaya Y; Hattori S; Miyagi Y; Onishi H; Okuda K
Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control.
Biochimica et biophysica acta 1993;1173(1):111-4.
1993: Kawamoto S; Shibano Y; Fukushima J; Ishii N; Morihara K; Okuda K
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.
Infection and immunity 1993;61(4):1400-5.
1993: Nishio M; Isobe Y; Hatano H; Ohno S; Okuda K; Ishii N
The genetic effect of engineered vaccine on Pseudomonas aeruginosa infection in mice.
Immunogenetics 1993;38(4):280-2.
1993: Okuda K; Kaneko T; Yamakawa T; Tanaka S; Hamajima K; Shigematsu T; Yamamato A; Kawamoto S
Strong synergistic effects of multicomponent vaccine for human immunodeficiency virus infection.
Journal of clinical & laboratory immunology 1993;40(3):97-113.
1992: Takeuchi H; Shibano Y; Morihara K; Fukushima J; Inami S; Keil B; Gilles A M; Kawamoto S; Okuda K
Structural gene and complete amino acid sequence of Vibrio alginolyticus collagenase.
The Biochemical journal 1992;281 ( Pt 3)():703-8.
1991: Kawamoto S; Onishi H; Hattori S; Miyagi Y; Amaya Y; Mishina M; Okuda K
Functional expression of the alpha 1 subunit of the AMPA-selective glutamate receptor channel, using a baculovirus system.
Biochemical and biophysical research communications 1991;181(2):756-63.
1991: Tanaka E; Kawamoto S; Fukushima J; Hamajima K; Onishi H; Miyagi Y; Inami S; Morihara K; Okuda K
Detection of elastase production in Escherichia coli with the elastase structural gene from several non-elastase-producing strains of Pseudomonas aeruginosa.
Journal of bacteriology 1991;173(19):6153-8.
1991: Fukushima J; Inami S; Okuda K
[Aspects on the molecular genetics of Pseudomonas aeruginosa; elastase, alkaline protease and other pathogenic factors]
Nippon rinsho. Japanese journal of clinical medicine 1991;49(10):2220-6.
1990: Okuda K; Morihara K; Atsumi Y; Takeuchi H; Kawamoto S; Kawasaki H; Suzuki K; Fukushima J
Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455.
Infection and immunity 1990;58(12):4083-8.
1990: Tanaka S; Nakajima S; Inoue S; Takamura Y; Aoki I; Okuda K
Genetic control by I-A subregion in H-2 complex of incidence of streptozocin-induced autoimmune diabetes in mice.
Diabetes 1990;39(10):1298-304.
1990: Fukushima J; Takeuchi H; Tanaka E; Hamajima K; Sato Y; Kawamoto S; Morihara K; Keil B; Okuda K
Molecular cloning and partial DNA sequencing of the collagenase gene of Vibrio alginolyticus.
Microbiology and immunology 1990;34(12):977-84.
1989: Atsumi Y; Yamamoto S; Morihara K; Fukushima J; Takeuchi H; Mizuki N; Kawamoto S; Okuda K
Cloning and expression of the alkaline proteinase gene from Pseudomonas aeruginosa IFO 3455.
Journal of bacteriology 1989;171(9):5173-5.
1989: Kawamoto S; Kaneko T; Mizuki N; Ohsuga A; Fukushima J; Amaya Y; Mori M; Okuda K
Molecular cloning and nucleotide sequence of rat brain argininosuccinate lyase cDNA with an extremely long 5'-untranslated sequence: evidence for the identity of the brain and liver enzymes.
Brain research. Molecular brain research 1989;5(3):235-41.
1989: Fukushima J; Yamamoto S; Morihara K; Atsumi Y; Takeuchi H; Kawamoto S; Okuda K
Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase.
Journal of bacteriology 1989;171(3):1698-704.
1989: Hikawa N; Horie H; Kawakami T; Okuda K; Takenaka T
Introduction of macromolecules into primary cultured neuronal cells by fusion with erythrocyte ghosts.
Brain research 1989;481(1):162-4.
1988: Ishii N; Aoki I; Ishii T; Mizuki N; Okuda K; Nakajima H
Suppressor T cells in mice made unresponsive to skin allografts.
The Journal of investigative dermatology 1988;91(4):333-5.
1988: Fukushima J; Tani K; Atsumi Y; Hamajima K; Kawamoto S; Okuda K
Trans-activation of class II (I-A alpha) gene by I-A beta gene transfection using bovine papilloma virus as a shuttle vector system.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):302-7.
1988: Yanoma S; Aoki I; Ishii N; Tani K; David C S; Okuda K
The role of autoreactive T-cell hybridomas from autoimmune model mice.
Immunology 1988;64(1):113-9.
1988: Yamamoto S; Fukushima J; Atsumi Y; Takeuchi H; Kawamoto S; Okuda K; Morihara K
Cloning and characterization of elastase structural gene from Pseudomonas aeruginosa IFO 3455.
Biochemical and biophysical research communications 1988;152(3):1117-22.
1988: Ishii N; Ichiyama S; Ishii T; Aoki I; Okuda K; Nakajima H
Genetic control of delayed-type hypersensitivity to D-penicillamine antigen.
International archives of allergy and applied immunology 1988;85(2):150-3.
1987: Ishii N; Kawaguchi H; Aoki I; Takahashi T; Okuda K; Nakajima H
Delayed-type hypersensitivity to allogeneic mouse epidermal cell antigens. III. Analysis of suppressor cells.
Experimental and clinical immunogenetics 1987;4(1):48-55.

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