FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

M Okuhara

Research Profile

Physiology

Fermentation

Living Beings

Phenomena

Chemicals & Drugs

Genes & Molecular Sequences

Molecular Structure

Occupations

Chemistry, Physical

Co-author Network

Publications

TOP 3
Akihiko Fujie; T Iwamoto; H Muramatsu; T Okudaira; Ikuko Sato; T Furuta; Yasuhisa Tsurumi; Yasuhiro Hori; Motohiro Hino; Seiji Hashimoto; M Okuhara
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. II. In vitro and in vivo activities.
Akihiko Fujie; T Iwamoto; H Muramatsu; T Okudaira; Kumiko Nitta; Tomoko Nakanishi; Kazutoshi Sakamoto; Yasuhiro Hori; Motohiro Hino; Seiji Hashimoto; M Okuhara
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
K Fujie; Y Shinguh; Noriaki Inamura; R Yasumitsu; M Okamoto; M Okuhara
Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of M Okuhara (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2000: Akihiko Fujie; T Iwamoto; H Muramatsu; T Okudaira; Ikuko Sato; T Furuta; Yasuhisa Tsurumi; Yasuhiro Hori; Motohiro Hino; Seiji Hashimoto; M Okuhara
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. II. In vitro and in vivo activities.
The Journal of antibiotics 2000;53(9):920-7.
2000: Akihiko Fujie; T Iwamoto; H Muramatsu; T Okudaira; Kumiko Nitta; Tomoko Nakanishi; Kazutoshi Sakamoto; Yasuhiro Hori; Motohiro Hino; Seiji Hashimoto; M Okuhara
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
The Journal of antibiotics 2000;53(9):912-9.
1999: K Fujie; Y Shinguh; Noriaki Inamura; R Yasumitsu; M Okamoto; M Okuhara
Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043.
European journal of pharmacology 1999;374(1):117-25.
1999: K Fujie; Y Shinguh; A Yamazaki; H Hatanaka; M Okamoto; M Okuhara
Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(3):160-7.
1998: Y Shinguh; A Yamazaki; Noriaki Inamura; K Fujie; M Okamoto; K Nakahara; Y Notsu; M Okuhara; T Ono
Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor.
European journal of pharmacology 1998;345(3):299-308.
1998: Seiji Yoshimura; T Otsuka; Y Muramatsu; T Fujiwara; M Okamoto; Seiji Hashimoto; M Okuhara
WA8242A1, A2 and B, novel secretory phospholipase A2 inhibitors produced by Streptomyces violaceusniger. II. Biological properties.
The Journal of antibiotics 1998;51(1):8-13.
1998: Seiji Yoshimura; T Otsuka; Yasuhisa Tsurumi; Y Muramatsu; H Hatanaka; M Okamoto; Seiji Hashimoto; M Okuhara
WA8242A1, A2 and B, novel secretory phospholipase A2 inhibitors produced by Streptomyces violaceusniger. I. Taxonomy, production and purification.
The Journal of antibiotics 1998;51(1):1-7.
1997: N Yamamoto; F Sakai; H Yamazaki; N Sato; K Nakahara; M Okuhara
FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-alpha, ameliorates endotoxin-induced shock.
European journal of pharmacology 1997;327(2-3):169-74.
1997: M Asano; Noriaki Inamura; Chie Hatori; H Sawai; T Fujiwara; Akira Katayama; Hiroshi Kayakiri; S Satoh; Y Abe; T Inoue; Y Sawada; K Nakahara; Teruo Oku; M Okuhara
The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657.
British journal of pharmacology 1997;120(4):617-24.
1997: Y Sakuma; H Hagihara; Akira Nagayoshi; K Ohne; Seitaro Mutoh; Y Ito; K Nakahara; Y Notsu; M Okuhara
Effects of FR145237, an acyl-CoA:cholesterol acyltransferase inhibitor, on diet-induced hypercholesterolemia in diabetic rats.
Life sciences 1997;60(6):351-6.
1996: Hidenori Nakajima; Y Hori; Hiroshi Terano; M Okuhara; Toshitaka Manda; Sanae Matsumoto; K Shimomura
New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action.
The Journal of antibiotics 1996;49(12):1204-11.
1996: Hidenori Nakajima; B Sato; T Fujita; Shigehiro Takase; Hiroshi Terano; M Okuhara
New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1996;49(12):1196-203.
1996: N Yamamoto; F Sakai; H Yamazaki; K Nakahara; M Okuhara
Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation.
European journal of pharmacology 1996;314(1-2):137-42.
1996: T Fujita; M Okamoto; Y Kosako; M Okuhara
Flexibacter japonensis sp. nov., a new species that produces a novel inhibitor of human leukocyte elastase isolated from soil.
Current microbiology 1996;33(2):89-93.
1996: Y Sakuma; H Hagihara; K Ohne; A Nagayoshi; S Mutoh; Y Ito; Y Notsu; M Okuhara
Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat.
Japanese journal of pharmacology 1996;70(1):35-41.
1996: K Sakamoto; E Tsujii; F Abe; T Nakanishi; M Yamashita; N Shigematsu; S Izumi; M Okuhara
FR901483, a novel immunosuppressant isolated from Cladobotryum sp. No. 11231. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1996;49(1):37-44.
1996: K Hayashi; M Nishikawa; Ichiro Aramori; S Kiyoto; M Okuhara
Tachykinin antagonists screening from microbial origin.
The Journal of antibiotics 1996;49(1):110-2.
1995: Seiji Yoshimura; Y Tsurumi; Shigehiro Takase; M Okuhara
WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. II. Structure elucidation of WS75624 A and B.
The Journal of antibiotics 1995;48(10):1073-5.
1995: Y Tsurumi; H Ueda; K Hayashi; Shigehiro Takase; M Nishikawa; S Kiyoto; M Okuhara
WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1995;48(10):1066-72.
1995: Hitoshi Kojo; O Nakayama; J Hirosumi; N Chida; Y Notsu; M Okuhara
Novel steroid 5 alpha-reductase inhibitor FK143: its dual inhibition against the two isozymes and its effect on transcription of the isozyme genes.
Molecular pharmacology 1995;48(3):401-6.
1995: N Oohata; Y Hori; Y Yamagishi; T Fujita; Shigehiro Takase; M Yamashita; Hiroshi Terano; M Okuhara
A new aromatase inhibitor, FR901537. I. Taxonomy, fermentation, isolation, physiochemical characteristics and biological activities.
The Journal of antibiotics 1995;48(8):757-62.
1995: K Sakamoto; S Izumi; M Miyauchi; M Okuhara
A new assay method for immunosuppressants with a tacrolimus (FK506)-like mode of action.
The Journal of antibiotics 1995;48(7):727-9.
1995: J Hirosumi; O Nakayama; N Chida; Masamichi Inami; T Fagan; K Sawada; S Shigematsu; Hitoshi Kojo; Y Notsu; M Okuhara
FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (2) In vivo effects on rat and dog prostates.
The Journal of steroid biochemistry and molecular biology 1995;52(4):365-73.
1995: J Hirosumi; O Nakayama; T Fagan; K Sawada; N Chida; Masamichi Inami; S Takahashi; Hitoshi Kojo; Y Notsu; M Okuhara
FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes.
The Journal of steroid biochemistry and molecular biology 1995;52(4):357-63.
1995: Y Tsurumi; K Fujie; M Nishikawa; S Kiyoto; M Okuhara
Biological and pharmacological properties of highly selective new endothelin converting enzyme inhibitor WS79089B isolated from Streptosporangium roseum No. 79089.
The Journal of antibiotics 1995;48(2):169-74.
1994: T Fujita; Y Shinguh; A Yamazaki; K Nakahara; M Okamoto; M Okuhara
FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. II. Pharmacological effect of FR901451.
The Journal of antibiotics 1994;47(12):1365-8.
1994: T Fujita; H Hatanaka; K Hayashi; N Shigematsu; Shigehiro Takase; M Okamoto; M Okuhara; K Shimatani; A Satoh
FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. I. Producing organism, fermentation, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1994;47(12):1359-64.
1994: Ichiro Aramori; N Morikawa; J Zenkoh; N O'Donnell; M Iwami; Hitoshi Kojo; Y Notsu; M Okuhara; S Ono; S Nakanishi
Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors.
European journal of pharmacology 1994;269(2):277-81.
1994: T Iwamoto; A Fujie; K Nitta; Seiji Hashimoto; M Okuhara; M Kohsaka
WF11899A, B and C, novel antifungal lipopeptides. II. Biological properties.
The Journal of antibiotics 1994;47(10):1092-7.
1994: T Iwamoto; A Fujie; K Sakamoto; Y Tsurumi; N Shigematsu; M Yamashita; Seiji Hashimoto; M Okuhara; M Kohsaka
WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.
The Journal of antibiotics 1994;47(10):1084-91.
1994: H Ueda; Hidenori Nakajima; Y Hori; T Goto; M Okuhara
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.
Bioscience, biotechnology, and biochemistry 1994;58(9):1579-83.
1994: Y Tsurumi; N Ohhata; T Iwamoto; N Shigematsu; K Sakamoto; M Nishikawa; S Kiyoto; M Okuhara
WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1994;47(6):619-30.
1994: H Ueda; Hidenori Nakajima; Y Hori; T Fujita; M Nishimura; T Goto; M Okuhara
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.
The Journal of antibiotics 1994;47(3):301-10.
1993: Y Hori; Y Abe; N Shigematsu; T Goto; M Okuhara; M Kohsaka
Napyradiomycins A and B1: non-steroidal estrogen-receptor antagonists produced by a Streptomyces.
The Journal of antibiotics 1993;46(12):1890-3.
1993: K Sakamoto; E Tsujii; M Miyauchi; T Nakanishi; M Yamashita; N Shigematsu; T Tada; S Izumi; M Okuhara
FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1993;46(12):1788-98.
1993: M Tanaka; Y Hori; F Sakai; H Ueda; T Goto; M Okuhara; Y Tsuda; Y Okada
WS1279, a novel lipopeptide isolated from Streptomyces willmorei. Biological activities.
The Journal of antibiotics 1993;46(11):1699-706.
1993: Y Hori; Y Abe; Hidenori Nakajima; Shigehiro Takase; T Fujita; T Goto; M Okuhara; M Kohsaka
WB2838 [3-chloro-4-(2-amino-3-chlorophenyl)-pyrrole]: non-steroidal androgen-receptor antagonist produced by a Pseudomonas.
The Journal of antibiotics 1993;46(9):1327-33.
1993: Y Hori; Y Abe; M Nishimura; T Goto; M Okuhara; M Kohsaka
R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. III. Pharmacological properties and antitumor activities.
The Journal of antibiotics 1993;46(7):1069-75.
1993: Y Hori; Shigehiro Takase; N Shigematsu; T Goto; M Okuhara; M Kohsaka
R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination.
The Journal of antibiotics 1993;46(7):1063-8.
1993: Y Hori; Y Abe; M Ezaki; T Goto; M Okuhara; M Kohsaka
R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 1993;46(7):1055-62.
1993: K Fujie; Y Shinguh; H Hatanaka; N Shigematsu; H Murai; T Fujita; M Yamashita; M Okamoto; M Okuhara
FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1993;46(6):908-13.
1993: M Tanaka; Y Hori; H Ueda; M Ezaki; T Goto; M Hashimoto; M Okuhara
WS1279, a novel lipopeptide isolated from Streptomyces willmorei. Fermentation, isolation and physico-chemical properties.
The Journal of antibiotics 1993;46(5):858-60.
1992: E Tsujii; N Shigematsu; H Hatanaka; M Yamashita; M Okamoto; M Okuhara
Novobiocin, an antagonist of leukotriene B4.
The Journal of antibiotics 1992;45(12):1958-60.
1992: M Hashimoto; K Hayashi; M Murai; T Fujii; M Nishikawa; S Kiyoto; M Okuhara; M Kohsaka; H Imanaka
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. II. Biological and pharmacological properties of WS9326A and tetrahydro-WS9326A (FK224)
The Journal of antibiotics 1992;45(7):1064-70.
1992: K Hayashi; M Hashimoto; N Shigematsu; M Nishikawa; M Ezaki; M Yamashita; S Kiyoto; M Okuhara; M Kohsaka; H Imanaka
WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1992;45(7):1055-63.
1992: S Miyata; M Hashimoto; K Fujie; M Shouho; K Sogabe; S Kiyoto; M Okuhara; M Kohsaka
WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. no. 89009. II. Biological characterization and pharmacological characterization of WS009 A and B.
The Journal of antibiotics 1992;45(7):1041-6.
1992: S Miyata; N Ohhata; H Murai; Y Masui; M Ezaki; Shigehiro Takase; M Nishikawa; S Kiyoto; M Okuhara; M Kohsaka
WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. no. 89009. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1992;45(7):1029-40.
1992: E Tsujii; Y Tsurumi; S Miyata; K Fujie; A Kawakami; M Okamoto; M Okuhara
WF11605, an antagonist of leukotriene B4 produced by a fungus. I. Producing strain, fermentation, isolation and biological activity.
The Journal of antibiotics 1992;45(5):698-703.
1992: T Otsuka; T Shibata; Y Tsurumi; Shigehiro Takase; M Okuhara; Hiroshi Terano; M Kohsaka; H Imanaka
A new angiogenesis inhibitor, FR-111142.
The Journal of antibiotics 1992;45(3):348-54.
1992: S Miyata; M Hashimoto; K Fujie; M Nishikawa; S Kiyoto; M Okuhara; M Kohsaka
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. II. Biological characterization and pharmacological characterization of WS-7338 B.
The Journal of antibiotics 1992;45(1):83-7.
1992: S Miyata; M Hashimoto; Y Masui; M Ezaki; Shigehiro Takase; M Nishikawa; S Kiyoto; M Okuhara; M Kohsaka
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1992;45(1):74-82.
1991: T Goto; T Kino; H Hatanaka; M Okuhara; M Kohsaka; H Aoki; H Imanaka
FK 506: historical perspectives.
Transplantation proceedings 1991;23(6):2713-7.
1991: S Izumi; T Ogawa; M Miyauchi; K Fujie; M Okuhara; M Kohsaka
Antitumor effect of Nocardia rubra cell wall skeleton on syngeneically transplanted P388 tumors.
Cancer research 1991;51(15):4038-44.
1990: O Nakayama; M Yagi; S Kiyoto; M Okuhara; M Kohsaka
Riboflavin, a testosterone 5 alpha-reductase inhibitor.
The Journal of antibiotics 1990;43(12):1615-6.
1990: O Nakayama; M Yagi; M Tanaka; S Kiyoto; I Uchida; M Hashimoto; M Okuhara; M Kohsaka
WS-7528, a new isoflavanone with estrogen activity isolated from Streptomyces sp. No. 7528. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
The Journal of antibiotics 1990;43(11):1394-402.
1990: T Iwamoto; A Fujie; Y Tsurumi; K Nitta; Seiji Hashimoto; M Okuhara
FR900403, a new antifungal antibiotic produced by a Kernia sp.
The Journal of antibiotics 1990;43(9):1183-5.
1990: M Yoshida; M Ezaki; M Hashimoto; M Yamashita; N Shigematsu; M Okuhara; M Kohsaka; K Horikoshi
A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1990;43(7):748-54.
1990: A Fujie; T Iwamoto; N Shigematsu; M Ezaki; Motohiro Hino; Seiji Hashimoto; M Okuhara; M Kohsaka; H Imanaka
FR112123, a new oligopeptide antibiotic from Streptomyces viridochromogenes. Taxonomy, fermentation, isolation, physico-chemical properties, structure and biological activity.
The Journal of antibiotics 1990;43(5):449-55.
1990: Seiji Hashimoto; H Murai; K Nitta; A Fujie; M Okuhara; M Kohsaka; H Imanaka
Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1.
The Journal of antibiotics 1990;43(3):281-5.
1990: Seiji Hashimoto; H Murai; M Ezaki; N Morikawa; H Hatanaka; M Okuhara; M Kohsaka; H Imanaka
Studies on new dehydropeptidase inhibitors. I. Taxonomy, fermentation, isolation and physico-chemical properties.
The Journal of antibiotics 1990;43(1):29-37.
1990: T Iwamoto; E Tsujii; M Ezaki; A Fujie; Seiji Hashimoto; M Okuhara; M Kohsaka; H Imanaka; K Kawabata; Y Inamoto
FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
The Journal of antibiotics 1990;43(1):1-7.
1989: Motohiro Hino; M Iwami; M Okamoto; K Yoshida; H Haruta; M Okuhara; J Hosoda; M Kohsaka; H Aoki; H Imanaka
FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
The Journal of antibiotics 1989;42(11):1578-83.
1989: O Nakayama; M Yagi; M Tanaka; S Kiyoto; M Okuhara; M Kohsaka
WS-9659 A and B, novel testosterone 5 alpha-reductase inhibitors isolated from a Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical characteristics.
The Journal of antibiotics 1989;42(8):1221-9.
1989: O Nakayama; H Arakawa; M Yagi; M Tanaka; S Kiyoto; M Okuhara; M Kohsaka
WS-9659 A and B, novel testosterone 5 alpha-reductase inhibitors isolated from a Streptomyces. III. Biological characteristics and pharmacological characteristics.
The Journal of antibiotics 1989;42(8):1235-40.
1989: M Iwami; O Nakayama; M Okuhara; Hiroshi Terano; M Kohsaka
New antitumor antibiotic, FR-900462. II. Production, isolation, characterization and biological activity.
The Journal of antibiotics 1989;42(5):686-90.
1989: M Nishimura; H Nakada; Ikuo Kawamura; T Mizota; K Shimomura; K Nakahara; T Goto; I Yamaguchi; M Okuhara
A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors.
The Journal of antibiotics 1989;42(4):553-7.
1989: M Nishimura; H Nakada; Hidenori Nakajima; Y Hori; M Ezaki; T Goto; M Okuhara
A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization.
The Journal of antibiotics 1989;42(4):542-8.
1989: H Hatanaka; T Kino; M Asano; T Goto; Hirokazu Tanaka; M Okuhara
FK-506 related compounds produced by Streptomyces tsukubaensis No. 9993.
The Journal of antibiotics 1989;42(4):620-2.
1988: H Hatanaka; M Iwami; T Kino; T Goto; M Okuhara
FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain.
The Journal of antibiotics 1988;41(11):1586-91.
1988: H Hatanaka; T Kino; S Miyata; N Inamura; A Kuroda; T Goto; Hirokazu Tanaka; M Okuhara
FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.
The Journal of antibiotics 1988;41(11):1592-601.
1988: T Shibata; O Nakayama; M Okuhara; Y Tsurumi; Hiroshi Terano; M Kohsaka
A new immunomodulator, FR-900490.
The Journal of antibiotics 1988;41(9):1163-9.
1988: H Hatanaka; T Kino; M Hashimoto; Y Tsurumi; A Kuroda; Hirokazu Tanaka; T Goto; M Okuhara
FR65814, a novel immunosuppressant isolated from a Penicillium strain. Taxonomy, fermentation, isolation, physico-chemical and biological characteristics and structure assignment.
The Journal of antibiotics 1988;41(8):999-1008.
1988: K Ochi; Y Tsurumi; N Shigematsu; M Iwami; K Umehara; M Okuhara
Physiological analysis of bicozamycin high-producing Streptomyces griseoflavus used at industrial level.
The Journal of antibiotics 1988;41(8):1106-15.
1988: T Shibata; O Nakayama; Y Tsurumi; M Okuhara; Hiroshi Terano; M Kohsaka
A new immunomodulator, FR-900483.
The Journal of antibiotics 1988;41(3):296-301.
1988: T Ando; Y Tsurumi; N Ohata; I Uchida; K Yoshida; M Okuhara
Vinigrol, a novel antihypertensive and platelet aggregation inhibitory agent produced by a fungus, Virgaria nigra. I. Taxonomy, fermentation, isolation, physicochemical and biological properties.
The Journal of antibiotics 1988;41(1):25-30.
1988: T Ando; K Yoshida; M Okuhara
Vinigrol, a novel antihypertensive and platelet aggregation inhibitory agent produced by a fungus, Virgaria nigra. II. Pharmacological characteristics.
The Journal of antibiotics 1988;41(1):31-5.
1987: M Nishikawa; Y Tsurumi; T Namiki; K Yoshida; M Okuhara
Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization.
The Journal of antibiotics 1987;40(10):1394-9.
1987: T Goto; T Kino; H Hatanaka; M Nishiyama; M Okuhara; M Kohsaka; H Aoki; H Imanaka
Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.
Transplantation proceedings 1987;19(5 Suppl 6):4-8.
1987: T Kino; N Inamura; F Sakai; K Nakahara; T Goto; M Okuhara; M Kohsaka; H Aoki; T Ochiai
Effect of FK-506 on human mixed lymphocyte reaction in vitro.
Transplantation proceedings 1987;19(5 Suppl 6):36-9.
1987: Hirokazu Tanaka; A Kuroda; Hiroshi Marusawa; M Hashimoto; H Hatanaka; T Kino; T Goto; M Okuhara
Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.
Transplantation proceedings 1987;19(5 Suppl 6):11-6.
1987: T Kino; H Hatanaka; S Miyata; N Inamura; M Nishiyama; T Yajima; T Goto; M Okuhara; M Kohsaka; H Aoki
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
The Journal of antibiotics 1987;40(9):1256-65.
1987: T Kino; H Hatanaka; M Hashimoto; M Nishiyama; T Goto; M Okuhara; M Kohsaka; H Aoki; H Imanaka
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.
The Journal of antibiotics 1987;40(9):1249-55.
1987: T Ando; S Okada; I Uchida; K Hemmi; M Nishikawa; Y Tsurumi; A Fujie; K Yoshida; M Okuhara
WF-10129, a novel angiotensin converting enzyme inhibitor produced by a fungus, Doratomyces putredinis.
The Journal of antibiotics 1987;40(4):468-75.