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Ko Okumura

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Seiji Kamijo; Akira Matsuda; Hironori Matsuda; Susumu Nakae; Keisuke Oboki; Hideoki Ogawa; Tatsukuni Ohno; Ko Okumura; Hirohisa Saito; Katsuko Sudo; Hajime Suto; Mayu Suzuki; Mutsuko Hara; Saori Ichikawa; Kyoko Inui; Haruna Takeda; Tomoko Tokura; Toshiro Takai
IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation.
Xue Chen; Francois Niyonsaba; Ko Okumura; Toshiro Takai; Yang Xie; Hideoki Ogawa
Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes.
Mutsuko Hara; Tomonobu Ito; Shunsuke Kanada; Nao Kitamura; Keiko Maeda; Makoto Nishiyama; Hideoki Ogawa; Ko Okumura; Naomi Shimokawa; Yoshihiko Usui; Hokuto Yokoyama; Kanako Fukuyama; Chiharu Nishiyama
Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.

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All Publications

2013: Seiji Kamijo; Akira Matsuda; Hironori Matsuda; Susumu Nakae; Keisuke Oboki; Hideoki Ogawa; Tatsukuni Ohno; Ko Okumura; Hirohisa Saito; Katsuko Sudo; Hajime Suto; Mayu Suzuki; Mutsuko Hara; Saori Ichikawa; Kyoko Inui; Haruna Takeda; Tomoko Tokura; Toshiro Takai
IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4489-99.
2013: Xue Chen; Francois Niyonsaba; Ko Okumura; Toshiro Takai; Yang Xie; Hideoki Ogawa
Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes.
Biochemical and biophysical research communications 2013;433(4):532-7.
2013: Mutsuko Hara; Tomonobu Ito; Shunsuke Kanada; Nao Kitamura; Keiko Maeda; Makoto Nishiyama; Hideoki Ogawa; Ko Okumura; Naomi Shimokawa; Yoshihiko Usui; Hokuto Yokoyama; Kanako Fukuyama; Chiharu Nishiyama
Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.
Molecular immunology 2013;53(3):295-301.
2013: Hisafumi Yamagata; Tomonori Aoyama; Kenichi Ikejima; Kazuyoshi Kon; Ko Okumura; Kazuyoshi Takeda; Sumio Watanabe
Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.
Hepatology research : the official journal of the Japan Society of Hepatology 2013;43(3):276-88.
2013: Minoru Fukuda; Keiichi Hiramatsu; Junko Kawasaki; Francois Niyonsaba; Ko Okumura; Mizuho Takeuchi; Hiroko Ushio; Tadashi Baba; Hideoki Ogawa
Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection.
Journal of innate immunity 2013;5(2):163-73.
2012: Xuehua Piao; Günther Schütz; Yasuo Uchiyama; Nico van Rooijen; Hideo Yagita; Hanno Ehlken; Mutsuko Hara; You-Wen He; Masato Koike; Sachiko Komazawa-Sakon; Hidetake Kurihara; Takashi Nishina; Masaki Ohmuraya; Ko Okumura; Jiang-Hu Piao; Hiroyasu Nakano
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Science signaling 2012;5(255):ra93.
2012: Ryusaku Matsuda; Yoshimichi Matsunaga; Chiharu Nishiyama; Hideoki Ogawa; Ko Okumura; Yoko Okunuki; Yoshihiko Usui; Naoyuki Yamakawa; Takeshi Kezuka; Hiroshi Goto
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis.
Investigative ophthalmology & visual science 2012;53(11):7235-45.
2012: Maho Suzukawa; Sachiko Yamaguchi; Tatsuya Yamasoba; Takayuki Yoshimoto; Ken Arae; David H Broide; Daniel J Cua; Akina Ishii; Yoichiro Iwakura; Naoki Kajiwara; Heinrich Körner; Kenji Matsumoto; Hideaki Morita; Wakako Nakanishi; Aya Nambu; Keisuke Oboki; Tatsukuni Ohno; Ken Ohta; Ko Okumura; Hirohisa Saito; Akiko Shibui; Eri Shimura; Katsuko Sudo; Hajime Suto; Keigo Suzukawa; Susumu Nakae
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(7):3641-52.
2012: Toan The Nguyen; Francois Niyonsaba; Toshihiro Akiyama; Shigaku Ikeda; Chanisa Kiatsurayanon; Ko Okumura; Rithee Smithrithee; Hiroko Ushio; Hideoki Ogawa
Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB.
Journal of dermatological science 2012;68(1):63-6.
2012: Yosuke Baba; Mutsuko Hara; Eisuke Inage; Keiko Maeda; François Niyonsaba; Hideoki Ogawa; Yoshikazu Ohtsuka; Ko Okumura; Toshiaki Shimizu; Ryuyo Suzuki; Takuya Yashiro; Chiharu Nishiyama
Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter.
Allergology international : official journal of the Japanese Society of Allergology 2012;61(3):461-7.
2012: Fumihiko Makino; Ko Okumura; Kazuhisa Takahashi; Hideo Yagita; Yoshiyuki Abe; Norihiro Harada; Jun Ito; Fumitaka Kamachi; Hisaya Akiba
Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.
American journal of respiratory cell and molecular biology 2012;47(3):298-305.
2012: Akiko Shibui; Eri Shimura; Katsuko Sudo; Sumio Sugano; Sachiko Yamaguchi; Warren J Leonard; Aya Nambu; Ko Okumura; Susumu Nakae
Th17 cell-derived IL-17 is dispensable for B cell antibody production.
Cytokine 2012;59(1):108-14.
2012: Yoshihiko Tashiro; Yuichi Tomiki; Takashi Dan; Ismael Gritli; Beate Heissig; Makoto Ishihara; Hiromitsu Komiyama; Toshio Miyata; Hiromitsu Nakauchi; Chiemi Nishida; Makiko Ohki-Koizumi; Ko Okumura; Kazuhiro Sakamoto; Aki Sato; Yayoi Sato; Kaori Sato-Kusubata; Koichi Hattori
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Blood 2012;119(26):6382-93.
2012: Yang Xie; Xue Chen; Ko Okumura; Toshiro Takai; Hideoki Ogawa
Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes.
Journal of dermatological science 2012;66(3):233-7.
2012: Hideaki Morita; Ken Arae; Naoki Kajiwara; Akio Matsuda; Kenji Matsumoto; Keisuke Oboki; Tatsukuni Ohno; Ko Okumura; Katsuko Sudo; Hajime Suto; Takao Takahashi; Susumu Nakae
ST2 requires Th2-, but not Th17-, type airway inflammation in epicutaneously antigen- sensitized mice.
Allergology international : official journal of the Japanese Society of Allergology 2012;61(2):265-73.
2012: M Kamijo; Nobuhiro Nakano; Chiharu Nishiyama; M Hara; Shigaku Ikeda; Ko Okumura; Atsushi Takagi; Hideoki Ogawa
Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease.
The British journal of dermatology 2012;166(5):1017-22.
2012: Daniel P Potaczek; Anetta Undas; Mutsuko Hara; Maya Kamijo; Ko Okumura; Chiharu Nishiyama
A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations.
Molecular biology reports 2012;39(4):3747-53.
2012: Nao Kitamura; Nobuhiro Nakano; Tatsuo Fukai; Mutsuko Hara; Shigaku Ikeda; Shunsuke Kanada; Makoto Nishiyama; Hideoki Ogawa; Ko Okumura; Takuya Yashiro; Hokuto Yokoyama; Chiharu Nishiyama
Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells.
The Journal of allergy and clinical immunology 2012;129(3):814-824.e6.
2012: Patcharee Ritprajak; Hideo Yagita; Hisaya Akiba; Masaaki Hashiguchi; Ko Okumura; Miyuki Azuma
Antibodies against B7-DC with differential binding properties exert opposite effects.
Hybridoma (2005) 2012;31(1):40-7.
2012: Takashi Nishina; Ko Okumura; Jiang-Hu Piao; Xuehua Piao; Tracy Putoczki; Emiko Sano; Kouhei Tsumoto; Takashi Ueno; Hiroko Ushio; Shunhei Yamashina; Saeko Yanaka; Dong-Mei Zheng; Takahiro Doi; Matthias Ernst; Junji Ezaki; Yuko Kojima; Sachiko Komazawa-Sakon; Hiroyasu Nakano
Interleukin-11 links oxidative stress and compensatory proliferation.
Science signaling 2012;5(207):ra5.
2011: Md Imranul Hoq; Francois Niyonsaba; Ko Okumura; Hiroko Ushio; Gyi Aung; Hideoki Ogawa
Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes.
Journal of dermatological science 2011;64(2):108-18.
2011: Kazuyoshi Takeda; Yoshihiro Hayakawa; Michio Imawari; Masafumi Nakayama; Kouetsu Ogasawara; Ko Okumura; Masashi Sakaki; Mark J Smyth
IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice.
Journal of leukocyte biology 2011;90(4):777-85.
2011: Akiko Shibui; Eri Shimura; Chiharu Shiraishi; Sumio Sugano; Sachiko Yamaguchi; Nobumichi Hozumi; Aya Nambu; Ko Okumura; Yoshitaka Sato; Susumu Nakae
Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation.
Allergology international : official journal of the Japanese Society of Allergology 2011;60(3):345-54.
2011: Jun Ito; Fumihiko Makino; Osamu Nagashima; Ko Okumura; Hisaya Akiba; Ryo Atsuta; Delbert R Dorscheid; Norihiro Harada; Yoshihiko Usui; Hideo Yagita; Kazuhisa Takahashi
Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α.
Biochemical and biophysical research communications 2011;412(1):109-14.
2011: Gyi Aung; Shigaku Ikeda; Francois Niyonsaba; Ko Okumura; Hiroko Ushio; Hideoki Ogawa
Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-κB activation.
Journal of dermatological science 2011;63(2):128-31.
2011: Daniel P Potaczek; A Undas; Anna Wojas-Pelc; M Nastalek; Ko Okumura; C Nishiyama
An association of TLR2–16934A >T polymorphism and severity/phenotype of atopic dermatitis.
Journal of the European Academy of Dermatology and Venereology : JEADV 2011;25(6):715-21.
2011: Junko Kawasaki; Hiroko Ushio; Hirokazu Kinoshita; Tatsuo Fukai; Francois Niyonsaba; Tshiro Takai; Hideoki Ogawa; Ko Okumura; Shigaku Ikeda
Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocytes.
Journal of dermatological science 2011;62(2):131-4.
2011: Hiroko Ushio; Takashi Ueno; Yuko Kojima; Masaaki Komatsu; Satoshi Tanaka; Akitsugu Yamamoto; Yoshinobu Ichimura; Junji Ezaki; Keigo Nishida; Sachiko Komazawa-Sakon; François Niyonsaba; Tetsuro Ishii; Toru Yanagawa; Eiki Kominami; Hideoki Ogawa; Ko Okumura; Hiroyasu Nakano
Crucial role for autophagy in degranulation of mast cells.
The Journal of allergy and clinical immunology 2011;127(5):1267-76.e6.
2011: Daniel P Potaczek; Magdalena Nastalek; Anna Wojas-Pelc; Ko Okumura; Anetta Undas; Chiharu Nishiyama
Naturally occurring FCER1A N222K mutation - its ethnicity-dependent distribution and a role in atopic dermatitis.
Molecular immunology 2011;48(8):979-80.
2011: Gyi Aung; Francois Niyonsaba; Hiroko Ushio; Naoki Kajiwara; Hirohisa Saito; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.
Immunology 2011;132(4):527-39.
2011: Juan Ma; Yoshihiko Usui; Kazuyoshi Takeda; Norihiro Harada; Hideo Yagita; Ko Okumura; Hisaya Akiba
TIM-1 signaling in B cells regulates antibody production.
Biochemical and biophysical research communications 2011;406(2):223-8.
2011: Daniel P Potaczek; Monika Pieculewicz; Marta Mazur; Agnieszka Branicka; Chiharu Nishiyama; Ko Okumura; Anetta Undas
Very rare minor homozygous GG genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebrovascular ischemic events.
International journal of cardiology 2011;147(1):e13-5.
2011: Gyi Aung; Francois Niyonsaba; Hiroko Ushio; M Imranul Hoq; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.
Journal of dermatological science 2011;61(2):142-4.
2011: Chiyomi Nishida; Mutsuko Hara; Yukio Itoh; Makoto Nishiyama; Hideoki Ogawa; Ko Okumura; Ryuyo Suzuki; Takeo Tomita; Chiharu Nishiyama
B-transferase with a Pro234Ser substitution acquires AB-transferase activity.
Bioscience, biotechnology, and biochemistry 2011;75(8):1570-5.
2011: Toshio Kawamoto; Yuko Kojima; Juan Ma; Fumihiko Makino; Shinji Morimoto; Ko Okumura; Yoshinari Takasaki; Yoshihiko Usui; Hideo Yagita; Yoshiyuki Abe; Jun Ito; Hisaya Akiba
Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
Arthritis research & therapy 2011;13(2):R47.
2011: Tuan Anh Le; Toshiro Takai; Anh Tuan Vu; Hirokazu Kinoshita; Xue Chen; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via toll-like receptor 5.
International archives of allergy and immunology 2011;155(1):31-7.
2010: Anh Tuan Vu; Tadashi Baba; Xue Chen; Tuan Anh Le; Hirokazu Kinoshita; Yang Xie; Seiji Kamijo; Keiichi Hiramatsu; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura; Toshiro Takai
Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway.
The Journal of allergy and clinical immunology 2010;126(5):985-93, 993.e1-3.
2010: Keiko Maeda; Chiharu Nishiyama; Hideoki Ogawa; Ko Okumura
GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4252-60.
2010: Yoshinori Yamanishi; Jiro Kitaura; Kumi Izawa; Ayako Kaitani; Yukiko Komeno; Masaki Nakamura; Satoshi Yamazaki; Yutaka Enomoto; Toshihiko Oki; Hisaya Akiba; Takaya Abe; Tadasuke Komori; Yoshihiro Morikawa; Hiroshi Kiyonari; Toshiyuki Takai; Ko Okumura; Toshio Kitamura
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
The Journal of experimental medicine 2010;207(7):1501-11.
2010: Hisashi Bashuda; Akira Shimizu; Masateru Uchiyama; Ko Okumura
Prolongation of renal allograft survival by anergic cells: advantages and limitations.
Clinical transplantation 2010;24 Suppl 22():6-10.
2010: Chiyomi Nishida; Chiharu Nishiyama; Koichi Satoh; Mutsuko Hara; Yukio Itoh; Hideoki Ogawa; Ko Okumura
Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells.
Legal medicine (Tokyo, Japan) 2010;12(4):172-6.
2010: Naomi Shimokawa; Chiharu Nishiyama; Nobuhiro Nakano; Keiko Maeda; Ryuyo Suzuki; Mutsuko Hara; Tatsuo Fukai; Tomoko Tokura; Hiroaki Miyajima; Atsuhito Nakao; Hideoki Ogawa; Ko Okumura
Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.
Immunogenetics 2010;62(7):421-9.
2010: Daniel P Potaczek; Danuta Owczarek; Dorota Cibor; Chiharu Nishiyama; Ko Okumura; Tomasz Mach; Anetta Undas
Tissue factor -1208D>I polymorphism is associated with D-dimer levels in patients with inflammatory bowel disease.
Inflammatory bowel diseases 2010;16(7):1095-6.
2010: Qing-hui Wang; Chiharu Nishiyama; Nobuhiro Nakano; Shunsuke Kanada; Mutsuko Hara; Nao Kitamura; Naomi Shimokawa; Chang-long Lu; Hideoki Ogawa; Ko Okumura
Opposite effects of Trichostatin A on activation of mast cells by different stimulants.
FEBS letters 2010;584(11):2315-20.
2010: Junya Fujimura; Kazuyoshi Takeda; Yuki Kaduka; Masahoro Saito; Hisaya Akiba; Hideo Yagita; Yuichiro Yamashiro; Toshiaki Shimizu; Ko Okumura
Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD.
Pediatric transplantation 2010;14(4):540-8.
2010: Makiko Ohki; Yuichi Ohki; Makoto Ishihara; Chiemi Nishida; Yoshihiko Tashiro; Haruyo Akiyama; Hiromitsu Komiyama; Leif R Lund; Atsumi Nitta; K Yamada; Zhenping Zhu; Hideoki Ogawa; Hideo Yagita; Ko Okumura; Hiromitsu Nakauchi; Zena Werb; Beate Heissig; Koichi Hattori
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Blood 2010;115(21):4302-12.
2010: Kazuyoshi Takeda; Yuko Kojima; Tomoyasu Uno; Yoshihiro Hayakawa; Michele W L Teng; Hirohisa Yoshizawa; Hideo Yagita; Fumitake Gejyo; Ko Okumura; Mark J Smyth
Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5493-501.
2010: Yusuke Niwa; Daniel P Potaczek; Shunsuke Kanada; Atsushi Takagi; N Shimokawa; Teruyo Ito; Kouichi Mitsuishi; Y Okubo; M Tajima; A Hobo; W Ng; Ryoji Tsuboi; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura; Chiharu Nishiyama
FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
International journal of immunogenetics 2010;37(2):139-41.
2010: Daniel P Potaczek; Beata Kwasny-Krochin; Chiharu Nishiyama; Ko Okumura; Piotr Gluszko; Anetta Undas
Tissue factor +5466A>G and -1208D>I genetic polymorphisms and severity of rheumatoid arthritis.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2010;48(3):423-5.
2010: Tuan Anh Le; Toshiro Takai; Anh Tuan Vu; Hirokazu Kinoshita; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in an atopic cytokine milieu more effectively than tacrolimus.
International archives of allergy and immunology 2010;153(1):27-34.
2010: Hiroshi Takenaka; Hiroko Ushio; Francois Niyonsaba; Sumanasiri T M Jayawardana; Suto Hajime; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands.
Biochemical and biophysical research communications 2010;391(1):471-6.
2009: Toshiro Takai; Takeshi Kato; Hideki Hatanaka; Kyoko Inui; Takuya Nakazawa; Saori Ichikawa; Kouichi Mitsuishi; Hideoki Ogawa; Ko Okumura
Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7958-65.
2009: Daniel P Potaczek; Q-H Wang; Marek Sanak; Tomoko Tokura; H Matsuda; S Dziedzina; Nobuhiro Nakano; M Hara; Hideoki Ogawa; Andrew Szczeklik; Ko Okumura; Chiharu Nishiyama
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.
Tissue antigens 2009;74(6):534-8.
2009: Daniel P Potaczek; Chiharu Nishiyama; Anetta Undas; Ko Okumura
Tissue factor genetic polymorphisms and haplotypes in Japanese population.
Atherosclerosis 2009;207(2):344-5.
2009: Seiji Kamijo; Toshiro Takai; Takatoshi Kuhara; Tomoko Tokura; Hiroko Ushio; Mikiko Ota; Norihiro Harada; Hideoki Ogawa; Ko Okumura
Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(10):6087-94.
2009: Yasuko Ishikawa; Tomoko Tokura; Hiroko Ushio; Francois Niyonsaba; Yuji Yamamoto; Tadahiro Tadokoro; Hideoki Ogawa; Ko Okumura
Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo.
Phytotherapy research : PTR 2009;23(11):1581-6.
2009: Tatsuo Fukai; Chiharu Nishiyama; Shunsuke Kanada; Nobuhiro Nakano; Mutsuko Hara; Tomoko Tokura; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Involvement of PU.1 in the transcriptional regulation of TNF-alpha.
Biochemical and biophysical research communications 2009;388(1):102-6.
2009: Xiao-Ling Wang; Toshiro Takai; Seiji Kamijo; Hendra Gunawan; Hideoki Ogawa; Ko Okumura
NADPH oxidase activity in allergenic pollen grains of different plant species.
Biochemical and biophysical research communications 2009;387(3):430-4.
2009: Daniel P Potaczek; Keiko Maeda; Qing-Hui Wang; Nobuhiro Nakano; Shunsuke Kanada; Ewa Stepien; Agnieszka Branicka; Tatsuo Fukai; Mutsuko Hara; Tomoko Tokura; Hideoki Ogawa; Anetta Undas; Ko Okumura; Chiharu Nishiyama
FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.
Immunogenetics 2009;61(9):649-55.
2009: Daniel P Potaczek; Ko Okumura; Chiharu Nishiyama
FCER1A genetic variability and serum IgE levels.
Allergy 2009;64(9):1383.
2009: Takeshi Kato; Toshiro Takai; T Fujimura; H Matsuoka; T Ogawa; K Murayama; A Ishii; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes.
Allergy 2009;64(9):1366-74.
2009: T A Le; T Takai; H Kinoshita; H Suto; S Ikeda; Ko Okumura; Hideoki Ogawa
Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
Allergy 2009;64(8):1231-2.
2009: Tomonobu Ito; Chiharu Nishiyama; Nobuhiro Nakano; Makoto Nishiyama; Yoshihiko Usui; Kazuyoshi Takeda; Shunsuke Kanada; Kanako Fukuyama; Hisaya Akiba; Tomoko Tokura; Mutsuko Hara; Ryoji Tsuboi; Hideoki Ogawa; Ko Okumura
Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma.
International immunology 2009;21(7):803-16.
2009: Toshiro Takai; Yuri Ochiai; Saori Ichikawa; Emi Sato; Takasuke Ogawa; Tomoko Tokura; Takatoshi Kuhara; Hiroshi Kawai; Hideki Hatanaka; Seizo Takahashi; Hideoki Ogawa; Ko Okumura
Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: a useful tool for the study of allergies in mouse models.
Allergology international : official journal of the Japanese Society of Allergology 2009;58(2):225-35.
2009: Teruji Totsuka; Takanori Kanai; Yasuhiro Nemoto; Takayuki Tomita; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Naoya Sakamoto; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6079-87.
2009: Masafumi Nakayama; Hisaya Akiba; Kazuyoshi Takeda; Yuko Kojima; Masaaki Hashiguchi; Miyuki Azuma; Hideo Yagita; Ko Okumura
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.
Blood 2009;113(16):3821-30.
2009: Yoshihiko Usui; Masaru Takeuchi; Takaaki Hattori; Yoko Okunuki; Kazumi Nagasawa; Takeshi Kezuka; Ko Okumura; Hideo Yagita; Hisaya Akiba; Hiroshi Goto
Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice.
Archives of ophthalmology 2009;127(4):514-9.
2009: Chiyoko Sekine; Yuko Moriyama; Akemi Koyanagi; Noriko Koyama; Hideko Ogata; Ko Okumura; Hideo Yagita
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands.
International immunology 2009;21(3):295-301.
2009: Takahiko Seto; Toshiro Takai; Nobuyuki Ebihara; Hiroyuki Matsuoka; Xiao-Ling Wang; Akira Ishii; Hideoki Ogawa; Akira Murakami; Ko Okumura
SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells.
Biochemical and biophysical research communications 2009;379(3):681-5.
2009: N Shimokawa; Chiharu Nishiyama; T Hirota; M Tamari; M Hara; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(2):228-35.
2009: Francois Niyonsaba; Asuka Suzuki; Hiroko Ushio; Isao Nagaoka; Hideoki Ogawa; Ko Okumura
The human antimicrobial peptide dermcidin activates normal human keratinocytes.
The British journal of dermatology 2009;160(2):243-9.
2009: François Niyonsaba; Isao Nagaoka; Hideoki Ogawa; Ko Okumura
Multifunctional antimicrobial proteins and peptides: natural activators of immune systems.
Current pharmaceutical design 2009;15(21):2393-413.
2009: Nobuhiro Nakano; Chiharu Nishiyama; Hideo Yagita; Akemi Koyanagi; Hisaya Akiba; Shigeru Chiba; Hideoki Ogawa; Ko Okumura
Notch signaling confers antigen-presenting cell functions on mast cells.
The Journal of allergy and clinical immunology 2009;123(1):74-81.e1.
2009: Hirokazu Kinoshita; Toshiro Takai; Tuan Anh Le; Seiji Kamijo; Xiao Ling Wang; Hiroko Ushio; Mutsuko Hara; Junko Kawasaki; Anh Tuan Vu; Takasuke Ogawa; Hendra Gunawan; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
The Journal of allergy and clinical immunology 2009;123(1):179-86.
2009: Daniel P Potaczek; Chiharu Nishiyama; Marek Sanak; Andrew Szczeklik; Ko Okumura
Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha).
Immunologic research 2009;45(1):75-84.
2008: Yusuke Niwa; Chiharu Nishiyama; Nobuhiro Nakano; Asuka Kamei; Hisanori Kato; Shunsuke Kanada; Shigaku Ikeda; Hideoki Ogawa; Ko Okumura
Opposite effects of PU.1 on mast cell stimulation.
Biochemical and biophysical research communications 2008;375(1):95-100.
2008: Qing-Hui Wang; Chiharu Nishiyama; Nobuhiro Nakano; Naomi Shimokawa; Mutsuko Hara; Shunsuke Kanada; Hideoki Ogawa; Ko Okumura
Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells.
Immunogenetics 2008;60(10):557-63.
2008: Taisuke Sawada; Chiharu Nishiyama; Takuma Kishi; Tomonari Sasazuki; Sachiko Komazawa-Sakon; Xin Xue; Jiang-Hu Piao; Hideko Ogata; Jun-ichi Nakayama; Tomohiko Taki; Yasuhide Hayashi; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.
The Journal of biological chemistry 2008;283(39):26820-8.
2008: Nobuyuki Ebihara; Toshinari Funaki; Hiroshi Matsuda; Ko Okumura; Akira Murakami; Chisei Ra
Corneal abnormalities in the NC/Nga mouse: an atopic dermatitis model.
Cornea 2008;27(8):923-9.
2008: Akihito Nakajima; Hidetake Kurihara; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death.
The Journal of biological chemistry 2008;283(35):24128-35.
2008: Kazuyoshi Takeda; Yuko Kojima; Kenichi Ikejima; Kenichi Harada; Shunhei Yamashina; Kyoko Okumura; Tomonori Aoyama; Steffen Frese; Hiroko Ikeda; Nicole M Haynes; Erika Cretney; Hideo Yagita; Noriyoshi Sueyoshi; Nobuhiro Sato; Yasuni Nakanuma; Mark J Smyth; Ko Okumura
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10895-900.
2008: Yan Zheng; Francois Niyonsaba; Hiroko Ushio; Shigaku Ikeda; Isao Nagaoka; Ko Okumura; Hideoki Ogawa
Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation.
Immunology 2008;124(3):357-67.
2008: Ying Liu; Kazu Mori; Naohito Ohno; Ko Okumura; Kazuyoshi Takeda; Yasushi Fukuwatari; Mai Furukawa; Ming Gao; Ken-Ichi Ishibashi; Masuro Motoi
Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers.
Evidence-based complementary and alternative medicine : eCAM 2008;5(2):205-19.
2008: Yuko Moriyama; Chiyoko Sekine; Akemi Koyanagi; Noriko Koyama; Hideko Ogata; Shigeru Chiba; Sachiko Hirose; Ko Okumura; Hideo Yagita
Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.
International immunology 2008;20(6):763-73.
2008: D P Potaczek; Chiharu Nishiyama; M Sanak; A Szczeklik; Ko Okumura; Hideoki Ogawa
FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects--a comparative analysis of haplotypes.
Allergy 2008;63(5):626-7.
2008: Yasuko Ishikawa; Tomoko Tokura; Nobuhiro Nakano; Mutsuko Hara; Francois Niyonsaba; Hiroko Ushio; Yuji Yamamoto; Tadahiro Tadokoro; Ko Okumura; Hideoki Ogawa
Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro.
Journal of medicinal food 2008;11(1):14-20.
2008: Hendra Gunawan; Toshiro Takai; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.
Allergology international : official journal of the Japanese Society of Allergology 2008;57(1):83-91.
2008: Masayuki Nagasawa; Zhu Yi; Shinsaku Imashuku; Shigeaki Nonoyama; Kazuyuki Ogawa; Ko Okumura; Shuki Mizutani
Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis.
American journal of hematology 2008;83(3):222-5.
2008: Muh Geot Wong; Yusuke Suzuki; Chiaki Tanifuji; Hisaya Akiba; Ko Okumura; Takeshi Sugaya; Tokunori Yamamoto; Satoshi Horikoshi; Si-Yen Tan; Carol Pollock; Yasuhiko Tomino
Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis.
Journal of the American Society of Nephrology : JASN 2008;19(2):290-7.
2008: William Ng; Chiharu Nishiyama; Masayuki Mizoguchi; Nobuhiro Nakano; Yasushi Suga; Shigaku Ikeda; Shigeru Itoh; Katsuyuki Kinoshita; Ko Okumura; Hideoki Ogawa
Human umbilical cord epithelial cells express Notch1: implications for its epidermal-like differentiation.
Journal of dermatological science 2008;49(2):143-52.
2008: Sumanasiri T M Jayawardana; Hiroko Ushio; Francois Niyonsaba; Srie Prihianti Gondokaryono; Hiroshi Takenaka; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis.
Biochemical and biophysical research communications 2008;365(1):137-42.
2008: A Nakajima; Y Kojima; M Nakayama; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells.
Oncogene 2008;27(1):76-84.
2008: Hendra Gunawan; Toshiro Takai; Seiji Kamijo; Xiao Ling Wang; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains.
International archives of allergy and immunology 2008;147(4):276-88.
2008: Nobuhiro Nakano; Chiharu Nishiyama; Tomoko Tokura; Yoko Nagasako-Akazome; Yasuyuki Ohtake; Ko Okumura; Hideoki Ogawa
Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation.
International archives of allergy and immunology 2008;147(3):213-21.
2008: Takasuke Ogawa; Toshiro Takai; Takeshi Kato; Yuko Kikuchi; Francois Niyonsaba; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1.
International archives of allergy and immunology 2008;146(1):27-35.
2008: Yoshiaki Ito; Takanori Kanai; Teruji Totsuka; Ryuichi Okamoto; Ken Tsuchiya; Yasuhiro Nemoto; A Yoshioka; T Tomita; T Nagaishi; N Sakamoto; T Sakanishi; Ko Okumura; Hideo Yagita; Masahiko Watanabe
Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G199-207.
2008: Atsushi Takagi; Chiharu Nishiyama; Keiko Maeda; Tomoko Tokura; Hiroshi Kawada; Shunsuke Kanada; Yusuke Niwa; Nobuhiro Nakano; Nobuyasu Mayuzumi; Makoto Nishiyama; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes.
The Journal of investigative dermatology 2008;128(1):96-103.
2007: Beate Heissig; Leif R Lund; Haruyo Akiyama; Makiko Ohki; Yohei Morita; John Rømer; Hiromitsu Nakauchi; Ko Okumura; Hideoki Ogawa; Zena Werb; Keld Danø; Koichi Hattori
The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.
Cell stem cell 2007;1(6):658-70.
2007: Takaaki Hattori; Yoshihiko Usui; Yoko Okunuki; Yasushi Sonoda; Masahiko Usui; Eiko Takada; Junichiro Mizuguchi; Hideo Yagita; Ko Okumura; Hisaya Akiba; Masaru Takeuchi
Blockade of the OX40 ligand prolongs corneal allograft survival.
European journal of immunology 2007;37(12):3597-604.
2007: Y Zheng; Francois Niyonsaba; Hiroko Ushio; Isao Nagaoka; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils.
The British journal of dermatology 2007;157(6):1124-31.
2007: Srie Prihianti Gondokaryono; Hiroko Ushio; Francois Niyonsaba; Mutsuko Hara; Hiroshi Takenaka; Sumanasiri T M Jayawardana; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4.
Journal of leukocyte biology 2007;82(3):657-65.
2007: Kazuyoshi Takeda; Ko Okumura; Mark J Smyth
Combination antibody-based cancer immunotherapy.
Cancer science 2007;98(9):1297-302.
2007: Yoshinori Seko; Hideo Yagita; Ko Okumura; Miyuki Azuma; Ryozo Nagai
Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.
Cardiovascular research 2007;75(1):158-67.
2007: Eri Yuminamochi; Taisuke Koike; Kazuyoshi Takeda; Isao Horiuchi; Ko Okumura
Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.
Immunology 2007;121(2):197-206.
2007: Nobuhiro Nakano; Chiharu Nishiyama; Shunsuke Kanada; Yusuke Niwa; Naomi Shimokawa; Hiroko Ushio; Makoto Nishiyama; Ko Okumura; Hideoki Ogawa
Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
Blood 2007;109(11):4846-55.
2007: Kazuyoshi Takeda; J Stagg; Hideo Yagita; Ko Okumura; Mark J Smyth
Targeting death-inducing receptors in cancer therapy.
Oncogene 2007;26(25):3745-57.
2007: Kazuyoshi Takeda; Ko Okumura
Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity.
The Journal of nutrition 2007;137(3 Suppl 2):791S-3S.
2007: Hitoshi Tsuchihashi; Toshio Hasegawa; Koji Sumiyoshi; Hideoki Ogawa; Shigaku Ikeda; Takashi Ando; Atsuhito Nakao; Ko Okumura
TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel.
Journal of dermatological science 2007;45(3):216-8.
2007: Francois Niyonsaba; Hiroko Ushio; Nobuhiro Nakano; William Ng; Koji Sayama; Koji Hashimoto; Isao Nagaoka; Ko Okumura; Hideoki Ogawa
Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.
The Journal of investigative dermatology 2007;127(3):594-604.
2007: Jiang-Hu Piao; Hisahiro Yoshida; Wen-Chen Yeh; Takahiro Doi; Xin Xue; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2272-7.
2007: Xuejun Chen; Francois Niyonsaba; Hiroko Ushio; Mutsuko Hara; Hidenori Yokoi; Kenji Matsumoto; Hirohisa Saito; Isao Nagaoka; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.
European journal of immunology 2007;37(2):434-44.
2006: Akihito Nakajima; Sachiko Komazawa-Sakon; Mutsuhiro Takekawa; Tomonari Sasazuki; Wen-Chen Yeh; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.
The EMBO journal 2006;25(23):5549-59.
2006: Koichi Kamata; Seiji Kamijo; Atsuo Nakajima; Akemi Koyanagi; Hisashi Kurosawa; Hideo Yagita; Ko Okumura
Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6433-9.
2006: Yoshihiko Usui; Hisaya Akiba; Masaru Takeuchi; Takeshi Kezuka; Aya Takeuchi; Takaaki Hattori; Yoko Okunuki; Yamazaki Tomohide; Hideo Yagita; Masahiko Usui; Ko Okumura
The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.
European journal of immunology 2006;36(11):3071-81.
2006: Tsunekazu Oikawa; Yosuke Kamimura; Hisaya Akiba; Hideo Yagita; Ko Okumura; Hiroki Takahashi; Mikio Zeniya; Hisao Tajiri; Miyuki Azuma
Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4281-7.
2006: Kazuyoshi Takeda; T Suzuki; S-I Shimada; Kan Shida; Masanobu Nanno; Ko Okumura
Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota.
Clinical and experimental immunology 2006;146(1):109-15.
2006: Atsushi Takagi; Chiharu Nishiyama; Shunsuke Kanada; Yusuke Niwa; Kanako Fukuyama; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Prolonged MHC class II expression and CIITA transcription in human keratinocytes.
Biochemical and biophysical research communications 2006;347(2):388-93.
2006: Seiji Kamijo; Atsuo Nakajima; Kaori Ikeda; Kazuhiro Aoki; Keiichi Ohya; Hisaya Akiba; Hideo Yagita; Ko Okumura
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody.
Biochemical and biophysical research communications 2006;347(1):124-32.
2006: Yuko Kikuchi; Toshiro Takai; Takatoshi Kuhara; Mikiko Ota; Takeshi Kato; Hideki Hatanaka; Saori Ichikawa; Tomoko Tokura; Hisaya Akiba; Kouichi Mitsuishi; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1609-17.
2006: Takanori Kanai; Koji Uraushihara; Teruji Totsuka; Yasuhiro Nemoto; Rei Fujii; Takahiro Kawamura; Shin Makita; Daisuke Sawada; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
Journal of gastroenterology and hepatology 2006;21(7):1136-42.
2006: Keiko Maeda; Chiharu Nishiyama; Tomoko Tokura; Hiroyasu Nakano; Shunsuke Kanada; Makoto Nishiyama; Ko Okumura; Hideoki Ogawa
FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice.
Blood 2006;108(1):262-9.
2006: Tomoyasu Uno; Kazuyoshi Takeda; Yuko Kojima; Hirohisa Yoshizawa; Hisaya Akiba; Robert S Mittler; Fumitake Gejyo; Ko Okumura; Hideo Yagita; Mark J Smyth
Eradication of established tumors in mice by a combination antibody-based therapy.
Nature medicine 2006;12(6):693-8.
2006: Hiroyasu Nakano; Akihito Nakajima; Sachiko Sakon-Komazawa; Jiang-Hu Piao; Xin Xue; Ko Okumura
Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.
Cell death and differentiation 2006;13(5):730-7.
2006: Yuko Kikuchi; Toshiro Takai; Mikiko Ota; Takeshi Kato; Ken Takeda; Kouichi Mitsuishi; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin.
International archives of allergy and immunology 2006;141(4):322-30.
2006: Toshiro Takai; Eri Mizuuchi; Yuko Kikuchi; Teruyuki Nagamune; Ko Okumura; Hideoki Ogawa
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation.
International archives of allergy and immunology 2006;139(3):181-7.
2005: Nobuhiro Nakano; Atsuhito Nakao; Takafumi Uchida; Norifumi Shirasaka; Hajime Yoshizumi; Ko Okumura; Ryoji Tsuboi; Hideoki Ogawa
Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells.
Biochimica et biophysica acta 2005;1738(1-3):19-28.
2005: Norihide Takaya; Youichi Katoh; Kazuhisa Iwabuchi; Ichiro Hayashi; Hakuoh Konishi; Seigo Itoh; Ko Okumura; Chisei Ra; Isao Nagaoka; Hiroyuki Daida
Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury.
Journal of molecular and cellular cardiology 2005;39(6):856-64.
2005: Yasushi Miyahira; Yasuhiro Takashima; Seiki Kobayashi; Yasunobu Matsumoto; Tsutomu Takeuchi; Mutsuko Ohyanagi-Hara; Ayako Yoshida; Akihiko Ohwada; Hisaya Akiba; Hideo Yagita; Ko Okumura; Hideoki Ogawa
Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.
Infection and immunity 2005;73(11):7356-65.
2005: Xuejun Chen; Francois Niyonsaba; Hiroko Ushio; Daiju Okuda; Isao Nagaoka; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli.
Journal of dermatological science 2005;40(2):123-32.
2005: Xin Xue; Jiang-Hu Piao; Akihito Nakajima; Sachiko Sakon-Komazawa; Yuko Kojima; Kazutoshi Mori; Hideo Yagita; Ko Okumura; Heather Harding; Hiroyasu Nakano
Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha.
The Journal of biological chemistry 2005;280(40):33917-25.
2005: Tomoko Tokura; Nobuhiro Nakano; Tomonobu Ito; Hironori Matsuda; Yoko Nagasako-Akazome; Tomomasa Kanda; Mitsuo Ikeda; Ko Okumura; Hideoki Ogawa; Chiharu Nishiyama
Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and FcepsilonRI.
Bioscience, biotechnology, and biochemistry 2005;69(10):1974-7.
2005: Beate Heissig; Shahin Rafii; Haruyo Akiyama; Yuichi Ohki; Yayoi Sato; Tejada Rafael; Zhenping Zhu; Daniel J Hicklin; Ko Okumura; Hideoki Ogawa; Zena Werb; Koichi Hattori
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.
The Journal of experimental medicine 2005;202(6):739-50.
2005: Hisaya Akiba; Kazuyoshi Takeda; Yuko Kojima; Yoshihiko Usui; Norihiro Harada; Yamazaki Tomohide; Juan Ma; Katsunari Tezuka; Hideo Yagita; Ko Okumura
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2340-8.
2005: Francois Niyonsaba; Hiroko Ushio; Isao Nagaoka; Ko Okumura; Hideoki Ogawa
The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1776-84.
2005: Yamazaki Tomohide; Hisaya Akiba; Akemi Koyanagi; Miyuki Azuma; Hideo Yagita; Ko Okumura
Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1586-92.
2005: N Nakano; Atsuhito Nakao; Kazumi Ishidoh; Ryoji Tsuboi; E Kominami; Ko Okumura; Hideoki Ogawa
CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes.
The British journal of dermatology 2005;153(1):37-45.
2005: Takeshi Kato; Toshiro Takai; Kouichi Mitsuishi; Ko Okumura; Hideoki Ogawa
Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases.
The Journal of allergy and clinical immunology 2005;116(1):169-76.
2005: Chiharu Nishiyama; Tomonobu Ito; Makoto Nishiyama; Shigehiro Masaki; Keiko Maeda; Nobuhiro Nakano; William Ng; Kanako Fukuyama; Masayuki Yamamoto; Ko Okumura; Hideoki Ogawa
GATA-1 is required for expression of Fc{epsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow.
International immunology 2005;17(7):847-56.
2005: Hisashi Bashuda; Masaaki Kimikawa; Kenichiro Seino; Yojiro Kato; Fumiko Ono; Akira Shimizu; Hideo Yagita; Satoshi Teraoka; Ko Okumura
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.
The Journal of clinical investigation 2005;115(7):1896-902.
2005: Toshiro Takai; Takeshi Kato; Mikiko Ota; Hiroshi Yasueda; Takatoshi Kuhara; Ko Okumura; Hideoki Ogawa
Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice.
International archives of allergy and immunology 2005;137(3):194-200.
2005: Tsuyoshi Ota; Kazuyoshi Takeda; Hisaya Akiba; Yoshihiro Hayakawa; Kouetsu Ogasawara; Yoshinori Ikarashi; Sachiko Miyake; Hiro Wakasugi; Takashi Yamamura; Mitchell Kronenberg; David H Raulet; Katsuyuki Kinoshita; Hideo Yagita; Mark J Smyth; Ko Okumura
IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.
Blood 2005;106(1):184-92.
2005: Toshitaka Tanaka; Tomohiko Ebata; Atsushi Tajima; Katsuyuki Kinoshita; Ko Okumura; Hideo Yagita
Beta2-microglobulin required for cell surface expression of blastocyst MHC.
Biochemical and biophysical research communications 2005;332(1):311-7.
2005: Yuki Kaduka; Kazuyoshi Takeda; Masafumi Nakayama; Katsuyuki Kinoshita; Hideo Yagita; Ko Okumura
TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.
Biochemical and biophysical research communications 2005;331(2):384-90.
2005: Hiroshi Kawada; Chiharu Nishiyama; Atsushi Takagi; Tomoko Tokura; Nobuhiro Nakano; Keiko Maeda; Nobuyasu Mayuzumi; Shigaku Ikeda; Ko Okumura; Hideoki Ogawa
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
The Journal of investigative dermatology 2005;124(6):1206-14.
2005: Teruji Totsuka; Takanori Kanai; Shin Makita; Rei Fujii; Yasuhiro Nemoto; Shigeru Oshima; Ryuichi Okamoto; Akemi Koyanagi; Hisaya Akiba; Ko Okumura; Hideo Yagita; Mamoru Watanabe
Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells.
European journal of immunology 2005;35(6):1773-85.
2005: Osamu Aramaki; Fumihiko Inoue; Tadatoshi Takayama; Motohide Shimazu; Masaki Kitajima; Yoshifumi Ikeda; Ko Okumura; Hideo Yagita; Nozomu Shirasugi; Masanori Niimi
Various costimulatory pathways are essential for induction of regulatory cells by intratracheal delivery of alloantigen.
Transplantation proceedings 2005;37(4):1934-6.
2005: Toshiro Takai; Masatoshi Takaoka; Hiroshi Yasueda; Ko Okumura; Hideoki Ogawa
Dilution method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens.
International archives of allergy and immunology 2005;137(1):1-8.
2005: Rintaroh Tsukahara; Masaru Takeuchi; Hisaya Akiba; Takeshi Kezuka; Kazuyoshi Takeda; Yoshihiko Usui; Masahiko Usui; Hideo Yagita; Ko Okumura
Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.
International immunology 2005;17(5):523-30.
2005: Hiroko Kimura; Fumiko Nagao; Yukio Tanaka; Shizu Sakai; S Tsuyoshi Ohnishi; Ko Okumura
Beneficial effects of the Nishino breathing method on immune activity and stress level.
Journal of alternative and complementary medicine (New York, N.Y.) 2005;11(2):285-91.
2005: Yutaka Kanamaru; Koji Sumiyoshi; Hiroko Ushio; Hideoki Ogawa; Ko Okumura; Atsuhito Nakao
Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4193-7.
2005: Takuya Nakazawa; Toshiro Takai; Hideki Hatanaka; Eri Mizuuchi; Teruyuki Nagamune; Ko Okumura; Hideoki Ogawa
Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure.
FEBS letters 2005;579(9):1988-94.
2005: Toshiro Takai; Takeshi Kato; Yasuhisa Sakata; Hiroshi Yasueda; Kenji Izuhara; Ko Okumura; Hideoki Ogawa
Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity.
Biochemical and biophysical research communications 2005;328(4):944-52.
2005: Osamu Aramaki; Fumihiko Inoue; Tadatoshi Takayama; Motohide Shimazu; Masaki Kitajima; Yoshifumi Ikeda; Ko Okumura; Hideo Yagita; Nozomu Shirasugi; Masanori Niimi
Interleukin-10 but not transforming growth factor-beta is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen.
Transplantation 2005;79(5):568-76.
2005: Toshiro Takai; Takeshi Kato; Hiroshi Yasueda; Ko Okumura; Hideoki Ogawa
Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains.
The Journal of allergy and clinical immunology 2005;115(3):555-63.
2005: Nobuhiro Nakano; Chiharu Nishiyama; Nobutaka Masuoka; Makoto Nishiyama; Hisakazu Yamane; Ko Okumura; Hideoki Ogawa
Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA.
Immunogenetics 2005;56(12):871-7.
2005: Kazuyoshi Takeda; Erika Cretney; Yoshihiro Hayakawa; Tsuyoshi Ota; Hisaya Akiba; Kouetsu Ogasawara; Hideo Yagita; Katsuyuki Kinoshita; Ko Okumura; Mark J Smyth
TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.
Blood 2005;105(5):2082-9.
2005: Hiroshi Kaneda; Kazuyoshi Takeda; Tsuyoshi Ota; Yuki Kaduka; Hisaya Akiba; Yoshinori Ikarashi; Hiro Wakasugi; Mitchell Kronenberg; Katsuyuki Kinoshita; Hideo Yagita; Ko Okumura
ICOS costimulates invariant NKT cell activation.
Biochemical and biophysical research communications 2005;327(1):201-7.
2005: Murat Mehmut; Kazuyoshi Takeda; Masaaki Abe; Hideko Ogata; Sachiko Hirose; Ko Okumura; Makoto Fujime
Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guérin treatment.
Urologia internationalis 2005;75(1):80-7.
2005: Tomonobu Ito; Chiharu Nishiyama; Makoto Nishiyama; Hironori Matsuda; Keiko Maeda; Yushiro Akizawa; Ryoji Tsuboi; Ko Okumura; Hideoki Ogawa
Mast cells acquire monocyte-specific gene expression and monocyte-like morphology by overproduction of PU.1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):376-83.
2004: Chiharu Nishiyama; Yushiro Akizawa; Makoto Nishiyama; Tomoko Tokura; Hiroshi Kawada; Kouichi Mitsuishi; Masanari Hasegawa; Tomonobu Ito; Nobuhiro Nakano; Atsushi Okamoto; Atsushi Takagi; Hideo Yagita; Ko Okumura; Hideoki Ogawa
Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6458-64.
2004: Hiroko Ushio; Atsuhito Nakao; Volaluck Supajatura; Kensuke Miyake; Ko Okumura; Hideoki Ogawa
MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN.
Biochemical and biophysical research communications 2004;323(2):491-8.
2004: Chinatsu Kasuga; Tomohiko Ebata; Nobuhiko Kayagaki; Hideo Yagita; Makoto Hishii; Hajime Arai; Kiyoshi Sato; Ko Okumura
Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.
Cancer science 2004;95(10):840-4.
2004: Hideo Yagita; Kazuyoshi Takeda; Yoshihiro Hayakawa; Mark J Smyth; Ko Okumura
TRAIL and its receptors as targets for cancer therapy.
Cancer science 2004;95(10):777-83.
2004: Chiharu Nishiyama; Nobutaka Masuoka; Makoto Nishiyama; Tomonobu Ito; Hisakazu Yamane; Ko Okumura; Hideoki Ogawa
Evidence against requirement of Ser41 and Ser45 for function of PU.1 -- molecular cloning of rat PU.1.
FEBS letters 2004;572(1-3):57-64.
2004: Kumi Inazaki; Yutaka Kanamaru; Yuko Kojima; Noriyoshi Sueyoshi; Ko Okumura; Kazunari Kaneko; Yuichiro Yamashiro; Hideoki Ogawa; Atsuhito Nakao
Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.
Kidney international 2004;66(2):597-604.
2004: Koji Sumiyoshi; Atsuhito Nakao; Yasuhiro Setoguchi; Ko Okumura; Hideoki Ogawa
Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model.
The Journal of investigative dermatology 2004;123(1):229-36.
2004: Tomonari Sasazuki; Tatsuma Okazaki; Kurisu Tada; Sachiko Sakon-Komazawa; Mitsuo Katano; Masao Tanaka; Hideo Yagita; Ko Okumura; Naoko Tominaga; Yoshihide Hayashizaki; Yasushi Okazaki; Hiroyasu Nakano
Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.
Molecular immunology 2004;41(5):547-51.
2004: Long Jin; Atsuhito Nakao; Masafumi Nakayama; Noriko Yamaguchi; Yuko Kojima; Nobuhiro Nakano; Ryoji Tsuboi; Ko Okumura; Hideo Yagita; Hideoki Ogawa
Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.
The Journal of investigative dermatology 2004;122(5):1175-9.
2004: Chiharu Nishiyama; Makoto Nishiyama; Tomonobu Ito; Shigehiro Masaki; Nobutaka Masuoka; Hisakazu Yamane; Toshio Kitamura; Hideoki Ogawa; Ko Okumura
Functional analysis of PU.1 domains in monocyte-specific gene regulation.
FEBS letters 2004;561(1-3):63-8.
2004: Kazuyoshi Takeda; Noriko Yamaguchi; Hisaya Akiba; Yuko Kojima; Yoshihiro Hayakawa; Jane E Tanner; Thomas J Sayers; Naoko Seki; Ko Okumura; Hideo Yagita; Mark J Smyth
Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.
The Journal of experimental medicine 2004;199(4):437-48.
2004: Chiharu Nishiyama; Makoto Nishiyama; Tomonobu Ito; Shigehiro Masaki; Keiko Maeda; Nobutaka Masuoka; Hisakazu Yamane; Toshio Kitamura; Hideoki Ogawa; Ko Okumura
Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression.
Biochemical and biophysical research communications 2004;313(3):516-21.
2004: Osamu Aramaki; Nozomu Shirasugi; Tadatoshi Takayama; Motohide Shimazu; Masaki Kitajima; Yoshifumi Ikeda; Miyuki Azuma; Ko Okumura; Hideo Yagita; Masanori Niimi
Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.
Transplantation 2004;77(1):6-12.
2004: Takahiro Kudo; Satoru Nagata; Yo Aoyagi; Ryuyo Suzuki; Hironori Matsuda; Yoshikazu Ohtsuka; Toshiaki Shimizu; Ko Okumura; Yuichiro Yamashiro
Polarized production of T-helper cell type 1 cells in Peyer's patches in Crohn's disease.
Digestion 2004;70(4):214-25.
2004: Yoshinori Seko; Kazuyuki Sugishita; Osamu Sato; Atsuhiko Takagi; Yusuke Tada; Hiroshi Matsuo; Hideo Yagita; Ko Okumura; Ryozo Nagai
Expression of costimulatory molecules (4-1BBL and Fas) and major histocompatibility class I chain-related A (MICA) in aortic tissue with Takayasu's arteritis.
Journal of vascular research 2004;41(1):84-90.
2003: Yasushi Miyahira; Hisaya Akiba; Masaharu Katae; Kaori Kubota; Seiki Kobayashi; Tsutomu Takeuchi; Adolfo García-Sastre; Yoshinosuke Fukuchi; Ko Okumura; Hideo Yagita; Takashi Aoki
Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6344-8.
2003: Yasushi Miyahira; Hisaya Akiba; Shu-Hei Ogawa; Tomohiro Ishi; Shiho Watanabe; Seiki Kobayashi; Tsutomu Takeuchi; Takashi Aoki; Katsunari Tezuka; Ryo Abe; Ko Okumura; Hideo Yagita; Naohiro Watanabe
Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections.
Immunology letters 2003;89(2-3):193-9.
2003: Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Shin Makita; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Hisaya Akiba; Hideo Yagita; Ko Okumura; Utako Machida; Hideyuki Iwai; Miyuki Azuma; Lieping Chen; Mamoru Watanabe
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4156-63.
2003: Jongkonnee Wongpiyabovorn; Hajime Suto; Hiroko Ushio; Kenji Izuhara; Kouichi Mitsuishi; Shigaku Ikeda; Atsuhito Nakao; Ko Okumura; Hideoki Ogawa
Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis.
Journal of dermatological science 2003;33(1):31-40.
2003: Toshinao Tsuge; Yusuke Suzuki; Toshibumi Shimokawa; Satoshi Horikoshi; Ko Okumura; Chisei Ra; Yasuhiko Tomino
Monocyte chemoattractant protein (MCP)-1 production via functionally reconstituted Fcalpha receptor (CD89) on glomerular mesangial cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(10):428-32.
2003: Fumihiko Tsushima; Hideyuki Iwai; Noriko Otsuki; Masaaki Abe; Sachiko Hirose; Yamazaki Tomohide; Hisaya Akiba; Hideo Yagita; Yuzo Takahashi; Ken Omura; Ko Okumura; Miyuki Azuma
Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses.
European journal of immunology 2003;33(10):2773-82.
2003: N Dan; Takanori Kanai; Teruji Totsuka; Ryoichi Iiyama; Motomi Yamazaki; Tokihiko Sawada; Tatsuya Miyata; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(4):G754-60.
2003: Osamu Aramaki; Nozomu Shirasugi; Yoshinobu Akiyama; Shintaro Shibutani; Tadatoshi Takayama; Motohide Shimazu; Masaki Kitajima; Yoshifumi Ikeda; Ko Okumura; Hideo Yagita; Masanori Niimi
CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen.
Transplantation 2003;76(5):772-6.
2003: Hideyuki Iwai; Masaaki Abe; Sachiko Hirose; Fumihiko Tsushima; Katsunari Tezuka; Hisaya Akiba; Hideo Yagita; Ko Okumura; Hitoshi Kohsaka; Nobuyuki Miyasaka; Miyuki Azuma
Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2848-54.
2003: Takao Hirano; Hiroaki Miyajima; Masatoshi Tateno; Kazuo Oshimi; Ko Okumura
[The chimerism and GVT effects on murine mini-transplantation model].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(9):1527-34.
2003: Koji Sumiyoshi; Atsuhito Nakao; Yasuhiro Setoguchi; Ko Okumura; Ryoji Tsuboi; Hideoki Ogawa
Smads regulate collagen gel contraction by human dermal fibroblasts.
The British journal of dermatology 2003;149(3):464-70.
2003: Masanari Hasegawa; Chiharu Nishiyama; Makoto Nishiyama; Yushiro Akizawa; Kouichi Mitsuishi; Tomonobu Ito; Hiroshi Kawada; Susumu Furukawa; Chisei Ra; Ko Okumura; Hideoki Ogawa
A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1927-33.
2003: Atsushi Tajima; Toshitaka Tanaka; Tomohiko Ebata; Kazuyoshi Takeda; Akemi Kawasaki; Janice M Kelly; Phillip K Darcy; Russell E Vance; David H Raulet; Katsuyuki Kinoshita; Ko Okumura; Mark J Smyth; Hideo Yagita
Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1715-21.
2003: Sachiko Sakon; Xin Xue; Mutsuhiro Takekawa; Tomonari Sasazuki; Tatsuma Okazaki; Yuko Kojima; Jian-Hu Piao; Hideo Yagita; Ko Okumura; Takahiro Doi; Hiroyasu Nakano
NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.
The EMBO journal 2003;22(15):3898-909.
2003: Masafumi Nakayama; Norihiro Harada; Ko Okumura; Hideo Yagita
Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies.
Biochemical and biophysical research communications 2003;306(4):819-25.
2003: Hidenori Yokoi; M Seki; S Okazoe; Ko Okumura; Hiroshi Yoshikawa
The role and expression of CD27 and CD70 lymphocytes in the human tonsil.
Lymphology 2003;36(2):74-83.
2003: Yasushi Miyahira; Masaharu Katae; Seiki Kobayashi; Tsutomu Takeuchi; Yoshinosuke Fukuchi; Ryo Abe; Ko Okumura; Hideo Yagita; Takashi Aoki
Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection.
Infection and immunity 2003;71(6):3131-7.
2003: Nozomu Shirasugi; Yoshinobu Akiyama; Osamu Aramaki; Shintaro Shibutani; Kenji Matsumoto; Hisashi Bashuda; Hideo Yagita; Ko Okumura; Yoshifumi Ikeda; Masanori Niimi
Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen.
Transplantation 2003;75(10):1636-9.
2003: Yushiro Akizawa; Chiharu Nishiyama; Masanari Hasegawa; Keiko Maeda; Tatsutoshi Nakahata; Ko Okumura; Chisei Ra; Hideoki Ogawa
Regulation of human FcepsilonRI beta chain gene expression by Oct-1.
International immunology 2003;15(5):549-56.
2003: Masanari Hasegawa; Chiharu Nishiyama; Makoto Nishiyama; Yushiro Akizawa; Kyoko Takahashi; Tomonobu Ito; Susumu Furukawa; Chisei Ra; Ko Okumura; Hideoki Ogawa
Regulation of the human Fc epsilon RI alpha-chain distal promoter.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3732-8.
2003: Teruji Totsuka; Takanori Kanai; Koji Uraushihara; Ryoichi Iiyama; Motomi Yamazaki; Hisaya Akiba; Hideo Yagita; Ko Okumura; Masahiko Watanabe
Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G595-603.
2003: Chiharu Nishiyama; Toyokazu Yokota; Makoto Nishiyama; Chisei Ra; Ko Okumura; Hideoki Ogawa
Molecular cloning of rat transcription factor YY1.
Bioscience, biotechnology, and biochemistry 2003;67(3):654-8.
2003: Toshinari Funaki; Atsuhito Nakao; Nobuyuki Ebihara; Yasuhiro Setoguchi; Yoshinosuke Fukuchi; Ko Okumura; Chisei Ra; Hideoki Ogawa; Atsushi Kanai
Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro.
Cornea 2003;22(2):153-9.
2003: Yasushi Miyahira; Masaharu Katae; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura; Seiki Kobayashi; Tsutomu Takeuchi; Tsuneo Kamiyama; Yoshinosuke Fukuchi; Takashi Aoki
Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi.
Infection and immunity 2003;71(3):1234-41.
2003: Koji Sumiyoshi; Atsuhito Nakao; Yasuhiro Setoguchi; Ryoji Tsuboi; Ko Okumura; Hideoki Ogawa
TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells.
Journal of dermatological science 2003;31(1):53-8.
2003: Teruji Totsuka; Takanori Kanai; Ryoichi Iiyama; Koji Uraushihara; Motomi Yamazaki; Ryuichi Okamoto; Toshifumi Hibi; Katsunari Tezuka; Miyuki Azuma; Hisaya Akiba; Hideo Yagita; Ko Okumura; Mamoru Watanabe
Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.
Gastroenterology 2003;124(2):410-21.
2003: Tatsuma Okazaki; Sachiko Sakon; Tomonari Sasazuki; Hiroaki Sakurai; Takahiro Doi; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses.
Biochemical and biophysical research communications 2003;300(4):807-12.
2003: Yutaka Kanamaru; Atsuhito Nakao; Yuichi Tanaka; Yutaka Inagaki; Hiroko Ushio; Isao Shirato; Satoshi Horikoshi; Ko Okumura; Hideoki Ogawa; Yasuhiko Tomino
Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells.
Nephron. Experimental nephrology 2003;95(1):e36-42.
2003: Takashi Muto; Shiun Dong Hsieh; Y Sakurai; H Yoshinaga; H Suto; Ko Okumura; Hideoki Ogawa
Prevalence of atopic dermatitis in Japanese adults.
The British journal of dermatology 2003;148(1):117-21.
2003: Masafumi Nakayama; Kazumi Ishidoh; Yuko Kojima; Norihiro Harada; Eiki Kominami; Ko Okumura; Hideo Yagita
Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):341-8.
2003: Keiko Maeda; Chiharu Nishiyama; Tomoko Tokura; Yushiro Akizawa; Makoto Nishiyama; Hideoki Ogawa; Ko Okumura; Chisei Ra
Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):334-40.
2002: Norihiro Harada; Masafumi Nakayama; Hiroyasu Nakano; Yoshinosuke Fukuchi; Hideo Yagita; Ko Okumura
Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.
Biochemical and biophysical research communications 2002;299(3):488-93.
2002: Atsuhito Nakao; Hironori Sagara; Yasuhiro Setoguchi; Takenori Okada; Ko Okumura; Hideoki Ogawa; Takeshi Fukuda
Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma.
The Journal of allergy and clinical immunology 2002;110(6):873-8.
2002: Takafumi Uchida; Hajime Suto; Chisei Ra; Hideoki Ogawa; Tetsuji Kobata; Ko Okumura
Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis.
International immunology 2002;14(12):1431-8.
2002: Yamazaki Tomohide; Hisaya Akiba; Hideyuki Iwai; Hironori Matsuda; Mami Aoki; Yuka Tanno; Tae Kwang Shin; Haruo Tsuchiya; Drew M Pardoll; Ko Okumura; Miyuki Azuma; Hideo Yagita
Expression of programmed death 1 ligands by murine T cells and APC.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5538-45.
2002: Toshiro Takai; Reiko Mineki; Takuya Nakazawa; Masatoshi Takaoka; Hiroshi Yasueda; Kimie Murayama; Ko Okumura; Hideoki Ogawa
Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity.
FEBS letters 2002;531(2):265-72.
2002: Nobuhiko Kayagaki; Noriko Yamaguchi; Masaaki Abe; Sachiko Hirose; Toshikazu Shirai; Ko Okumura; Hideo Yagita
Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL).
Cellular immunology 2002;219(2):82-91.
2002: Yoshinobu Akiyama; Nozomu Shirasugi; Norio Uchida; Kenji Matsumoto; Masaki Kitajima; Hisashi Bashuda; Hideo Yagita; Ko Okumura; Osamu Aramaki; Masanori Niimi
B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.
Transplantation 2002;74(5):732-8.
2002: Masaharu Katae; Yasushi Miyahira; Kazuyoshi Takeda; Hironori Matsuda; Hideo Yagita; Ko Okumura; Tsutomu Takeuchi; Tsuneo Kamiyama; Akihiko Ohwada; Yoshinosuke Fukuchi; Takashi Aoki
Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy.
Infection and immunity 2002;70(9):4833-40.
2002: Yuko Kojima; Akemi Kawasaki-Koyanagi; Noriyoshi Sueyoshi; Atsushi Kanai; Hideo Yagita; Ko Okumura
Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.
Biochemical and biophysical research communications 2002;296(2):328-36.
2002: Tomonari Sasazuki; Taisuke Sawada; Sachiko Sakon; Toshio Kitamura; Takuma Kishi; Tatsuma Okazaki; Mitsuo Katano; Masao Tanaka; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
The Journal of biological chemistry 2002;277(32):28853-60.
2002: Nobuyuki Ebihara; Ko Okumura; Kiyoo Nakayasu; Atsushi Kanai; Chisei Ra
High level of Fc epsilon receptor I-bindable immunoglobulin E in the tear fluid and increased immunoglobulin E-saturated cells in the giant papillae of vernal keratoconjunctivitis patients.
Japanese journal of ophthalmology 2002;46(4):357-63.
2002: Yutaka Kanamaru; Atsuhito Nakao; Isao Shirato; Ko Okumura; Hideoki Ogawa; Yasuhiko Tomino; Chisei Ra
Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy.
Journal of the American Society of Nephrology : JASN 2002;13(6):1527-33.
2002: Chiharu Nishiyama; Kyoko Takahashi; Yasuyuki Ohtake; Toyokazu Yokota; Ko Okumura; Hideoki Ogawa; Chisei Ra
Analysis of transactivation region of Elf-1 by using a yeast one-hybrid system.
Bioscience, biotechnology, and biochemistry 2002;66(5):1105-7.
2002: Hiroaki Miyajima; Naohiro Watanabe; Zoltan Ovary; Ko Okumura; Takao Hirano
Rat monoclonal anti-murine IgE antibody removes IgE molecules already bound to mast cells or basophilic leukemia cells, resulting in the inhibition of systemic anaphylaxis and passive cutaneous anaphylaxis.
International archives of allergy and immunology 2002;128(1):24-32.
2002: Yoshinori Seko; Shigeru Ishiyama; Toshiro Nishikawa; Takeshi Kasajima; Michiaki Hiroe; Shin Suzuki; Sugao Ishiwata; Sachio Kawai; Yuetsu Tanaka; Miyuki Azuma; Tetsuji Kobata; Hideo Yagita; Ko Okumura; Ryozo Nagai
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2002;11(3):166-70.
2002: Volaluck Supajatura; Hiroko Ushio; Atsuhito Nakao; Shizuo Akira; Ko Okumura; Chisei Ra; Hideoki Ogawa
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.
The Journal of clinical investigation 2002;109(10):1351-9.
2002: Chiharu Nishiyama; Masanari Hasegawa; Makoto Nishiyama; Kyoko Takahashi; Yushiro Akizawa; Toyokazu Yokota; Ko Okumura; Hideoki Ogawa; Chisei Ra
Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4546-52.
2002: Yoshinori Seko; Nobuhiko Kayagaki; Ken-ichiro Seino; Hideo Yagita; Ko Okumura; Ryozo Nagai
Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3.
Journal of the American College of Cardiology 2002;39(8):1399-403.
2002: Ryuyo Suzuki; Atsuhito Nakao; Yutaka Kanamaru; Ko Okumura; Hideoki Ogawa; Chisei Ra
Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factor-beta.
International immunology 2002;14(4):339-45.
2002: Volaluck Supajatura; Hiroko Ushio; Akihiro Wada; Kinnosuke Yahiro; Ko Okumura; Hideoki Ogawa; Toshiya Hirayama; Chisei Ra
Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2603-7.
2002: Masato Yamada; Hideo Yagita; Hideko Inoue; Tsuyoshi Takanashi; Hironori Matsuda; Eiko Munechika; Yutaka Kanamaru; Isao Shirato; Yasuhiko Tomino; Kouji Matushima; Ko Okumura; Hiroshi Hashimoto
Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis.
Arthritis and rheumatism 2002;46(3):735-40.
2002: Toshiro Futagawa; Hisaya Akiba; Tomohiro Kodama; Kazuyoshi Takeda; Yasuyuki Hosoda; Hideo Yagita; Ko Okumura
Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells.
International immunology 2002;14(3):275-86.
2002: Koji Sumiyoshi; Atsuhito Nakao; Hiroko Ushio; Kouichi Mitsuishi; Ko Okumura; Ryoji Tsuboi; Chisei Ra; Hideoki Ogawa
Transforming growth factor-beta1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(2):309-14.
2002: Noriyoshi Kobayashi; Yusuke Suzuki; Toshinao Tsuge; Ko Okumura; Chisei Ra; Yasuhiko Tomino
FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells.
American journal of physiology. Renal physiology 2002;282(2):F358-65.
2002: Kazuyoshi Takeda; Mark J Smyth; Erika Cretney; Yoshihiro Hayakawa; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development.
The Journal of experimental medicine 2002;195(2):161-9.
2002: Masafumi Nakayama; Kazumi Ishidoh; Nobuhiko Kayagaki; Yuko Kojima; Noriko Yamaguchi; Hiroyasu Nakano; Eiki Kominami; Ko Okumura; Hideo Yagita
Multiple pathways of TWEAK-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):734-43.
2002: Fumie Kagaya; Junko Hori; Kazutaka Kamiya; Yuichi Kaji; Tetsuro Oshika; Shiro Amano; Satoru Yamagami; Tadahiko Tsuru; Sumiyoshi Tanaka; Hironori Matsuda; Hideo Yagita; Ko Okumura
Inhibition of murine corneal allograft rejection by treatment with antibodies to CD80 and CD86.
Experimental eye research 2002;74(1):131-9.
2001: Kazuyoshi Takeda; Mark J Smyth; Erika Cretney; Yoshihiro Hayakawa; Noriko Yamaguchi; Hideo Yagita; Ko Okumura
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth.
Cellular immunology 2001;214(2):194-200.
2001: Yoshinori Seko; N Takahashi; H Oshima; O Shimozato; Hisaya Akiba; K Takeda; Tetsuji Kobata; Hideo Yagita; Ko Okumura; Masahiko Azuma; Ryozo Nagai
Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3.
The Journal of pathology 2001;195(5):593-603.
2001: K Sato; S Hida; Hiroshi Takayanagi; Taeko Yokochi; Nobuhiko Kayagaki; K Takeda; Hideo Yagita; Ko Okumura; Naomi Tanaka; Tadatsugu Taniguchi; Kouetsu Ogasawara
Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta.
European journal of immunology 2001;31(11):3138-46.
2001: K Nozawa; J Ohata; J Sakurai; Hiroshi Hashimoto; H Miyajima; H Yagita; Ko Okumura; Miyuki Azuma
Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4981-6.
2001: Toyoyoshi Uchida; Atsuhito Nakao; N Nakano; Atsuo Kuramasu; H Saito; Ko Okumura; Chisei Ra; Hideoki Ogawa
Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells.
Biochemical and biophysical research communications 2001;288(1):137-41.
2001: K Tada; Tatsuma Okazaki; Sachiko Sakon; T Kobarai; K Kurosawa; S Yamaoka; H Hashimoto; T W Mak; Hideo Yagita; Ko Okumura; Wen-Chen Yeh; Hiroyasu Nakano
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.
The Journal of biological chemistry 2001;276(39):36530-4.
2001: Kazuyoshi Takeda; Ko Okumura
[Current advances and expectations in tumor immunology].
Human cell 2001;14(3):159-63.
2001: Volaluck Supajatura; Hiroko Ushio; Atsuhito Nakao; Ko Okumura; Chisei Ra; Hideoki Ogawa
Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2250-6.
2001: T Okazaki; Atsuhito Nakao; Hiroyasu Nakano; F Takahashi; Kyoko Takahashi; O Shimozato; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura
Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1977-81.
2001: Chiharu Nishiyama; Masanari Hasegawa; Makoto Nishiyama; Kyoko Takahashi; Toyokazu Yokota; Ko Okumura; Chisei Ra
Cloning of full-length genomic DNA encoding human FcepsilonRI alpha-chain and its transcriptional regulation.
Biochemical and biophysical research communications 2001;284(4):1056-64.
2001: T Ebata; S Mogi; Y Hata; J I Fujimoto; H Yagita; Ko Okumura; Miyuki Azuma
Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation.
European journal of immunology 2001;31(5):1410-6.
2001: Nozomu Shirasugi; Yoshifumi Ikeda; Yoshinobu Akiyama; Kenji Matsumoto; K Hamano; K Esato; Hisashi Bashuda; Hideo Yagita; Ko Okumura; Hiroshi Takami; Susumu Kodaira; Masanori Niimi
Induction of hyporesponsiveness to fully allogeneic cardiac grafts by intratracheal delivery of alloantigen.
Transplantation 2001;71(4):561-4.
2001: Yutaka Kanamaru; Atsuhito Nakao; M Mamura; Yusuke Suzuki; Isao Shirato; Ko Okumura; Yasuhiko Tomino; Chisei Ra
Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2818-23.
2001: C Nohara; Hisaya Akiba; Atsuo Nakajima; A Inoue; C S Koh; H Ohshima; Hideo Yagita; Yoshikuni Mizuno; Ko Okumura
Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2108-15.
2001: Toshiro Takai; Ko Okumura; Chisei Ra
Direct expression of the extracellular portion of human FcepsilonRIalpha chain as inclusion bodies in Escherichia coli.
Bioscience, biotechnology, and biochemistry 2001;65(1):79-85.
2001: Kazuyoshi Takeda; Yoshihiro Hayakawa; Mark J Smyth; Nobuhiko Kayagaki; Noriko Yamaguchi; S Kakuta; Y Iwakura; Hideo Yagita; Ko Okumura
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.
Nature medicine 2001;7(1):94-100.
2000: Fumiko Nagao; M Nakayama; T Muto; Ko Okumura
Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects.
Bioscience, biotechnology, and biochemistry 2000;64(12):2706-8.
2000: S Mogi; J Sakurai; T Kohsaka; S Enomoto; H Yagita; Ko Okumura; Miyuki Azuma
Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells.
Immunology 2000;101(4):541-7.
2000: Masafumi Nakayama; Nobuhiko Kayagaki; Noriko Yamaguchi; Ko Okumura; Hideo Yagita
Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity.
The Journal of experimental medicine 2000;192(9):1373-80.
2000: Nozomu Shirasugi; S Matsumoto; K Hamano; K Esato; Kenji Matsumoto; Hisashi Bashuda; Hideo Yagita; Ko Okumura; Yoshifumi Ikeda; Hiroshi Takami; Susumu Kodaira; Masanori Niimi
Survival of fully allogeneic cardiac allografts induced by delivery of alloantigen via respiratory mucosa is abrogated by blockade of the B7 pathway.
Transplantation proceedings 2000;32(7):2034.
2000: Fumiko Nagao; M Suzui; K Takeda; Hideo Yagita; Ko Okumura
Mobilization of NK cells by exercise: downmodulation of adhesion molecules on NK cells by catecholamines.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1251-6.
2000: Toshiro Takai; T Yuuki; N Iwamoto-Yasue; Ko Okumura; Chisei Ra
Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions.
Bioscience, biotechnology, and biochemistry 2000;64(9):1856-67.
2000: Toshibumi Shimokawa; Toshinao Tsuge; Ko Okumura; Chisei Ra
Identification and characterization of the promoter for the gene encoding the human myeloid IgA Fc receptor (FcalphaR, CD89).
Immunogenetics 2000;51(11):945-54.
2000: Yoshinori Seko; N Takahashi; Yusuke Tada; Hideo Yagita; Ko Okumura; Ryozo Nagai
Restricted usage of T-cell receptor Vgamma-Vdelta genes and expression of costimulatory molecules in Takayasu's arteritis.
International journal of cardiology 2000;75 Suppl 1():S77-83; discussion S85-7.
2000: K Hattori; Takao Hirano; Kazuo Oshimi; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation.
Leukemia & lymphoma 2000;38(5-6):553-61.
2000: Atsuhito Nakao; S Miike; M Hatano; Ko Okumura; T Tokuhisa; Chisei Ra; I Iwamoto
Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity.
The Journal of experimental medicine 2000;192(2):151-8.
2000: Y Furumoto; S Hiraoka; K Kawamoto; Shigehiro Masaki; Tsuneo Kitamura; Ko Okumura; Chisei Ra
Polymorphisms in FcepsilonRI beta chain do not affect IgE-mediated mast cell activation.
Biochemical and biophysical research communications 2000;273(2):765-71.
2000: M Noguchi; N Sakamoto; Ko Okumura; Naotake Sato; K Yamada; Yasushi Isobe; Atsushi Kato; Kazuo Oshimi
[CD8-positive diffuse large B-cell lymphoma].
[Rinshō ketsueki] The Japanese journal of clinical hematology 2000;41(7):591-5.
2000: Kazuyoshi Takeda; Y Hayakawa; M Atsuta; S Hong; L Van Kaer; K Kobayashi; M Ito; Hideo Yagita; Ko Okumura
Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12.
International immunology 2000;12(6):909-14.
2000: Kazuyoshi Takeda; Y Hayakawa; L Van Kaer; H Matsuda; Hideo Yagita; Ko Okumura
Critical contribution of liver natural killer T cells to a murine model of hepatitis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5498-503.
2000: Hiromichi Tsurui; Hiroyuki Nishimura; S Hattori; Sachiko Hirose; Ko Okumura; Toshikazu Shirai
Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(5):653-62.
2000: Y Satake; Hisaya Akiba; Kazuyoshi Takeda; M Atsuta; Hideo Yagita; Ko Okumura
Characterization of rat OX40 ligand by monoclonal antibody.
Biochemical and biophysical research communications 2000;270(3):1041-8.
2000: Toshibumi Shimokawa; Ko Okumura; Chisei Ra
DNA induces apoptosis in electroporated human promonocytic cell line U937.
Biochemical and biophysical research communications 2000;270(1):94-9.
2000: N Tsukada; Hisaya Akiba; Tetsuji Kobata; Y Aizawa; Hideo Yagita; Ko Okumura
Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation.
Blood 2000;95(7):2434-9.
2000: Kazuyoshi Takeda; H Oshima; Y Hayakawa; Hisaya Akiba; M Atsuta; Tetsuji Kobata; K Kobayashi; M Ito; Hideo Yagita; Ko Okumura
CD27-mediated activation of murine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1741-5.
2000: M Noguchi; Ko Okumura; Atsushi Kato; T Hirano; Kazuo Oshimi
[Rapidly progressive, refractory eosinophilia with a 250,000/microliter eosinophil count].
[Rinshō ketsueki] The Japanese journal of clinical hematology 2000;41(2):135-9.
2000: T Kawamura; Miyuki Azuma; N Kayagaki; S Shimada; Hideo Yagita; Ko Okumura
Fas/Fas ligand-mediated apoptosis of murine Langerhans cells.
Journal of dermatological science 2000;22(2):96-101.
2000: Hisaya Akiba; Yasushi Miyahira; M Atsuta; Kazuyoshi Takeda; C Nohara; Toshiro Futagawa; Hironori Matsuda; Takashi Aoki; Hideo Yagita; Ko Okumura
Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis.
The Journal of experimental medicine 2000;191(2):375-80.
2000: J Sakurai; J Ohata; K Saito; H Miyajima; T Hirano; T Kohsaka; S Enomoto; Ko Okumura; Miyuki Azuma
Blockade of CTLA-4 signals inhibits Th2-mediated murine chronic graft-versus-host disease by an enhanced expansion of regulatory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):664-9.
2000: Ko Okumura; Koshiro Fukiyama
[Hypertension and sudden death].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():800-3.
1999: H Morita; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura
Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro.
Biochemical and biophysical research communications 1999;264(2):321-6.
1999: Hiroyasu Nakano; Sachiko Sakon; H Koseki; T Takemori; K Tada; M Matsumoto; E Munechika; T Sakai; T Shirasawa; Hisaya Akiba; Tetsuji Kobata; SM Santee; Carl Ware; P D Rennert; M Taniguchi; Hideo Yagita; Ko Okumura
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9803-8.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; Kazuyoshi Takeda; Hisaya Akiba; H Tsutsui; H Okamura; K Nakanishi; Ko Okumura; Hideo Yagita
Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1906-13.
1999: T Kawamura; Miyuki Azuma; N Kayagaki; S Shimada; Hideo Yagita; Ko Okumura
Fas/Fas ligand-mediated elimination of antigen-bearing Langerhans cells in draining lymph nodes.
The British journal of dermatology 1999;141(2):201-5.
1999: Yoshinori Seko; N Takahashi; H Oshima; O Shimozato; Hisaya Akiba; Tetsuji Kobata; Hideo Yagita; Ko Okumura; Masahiko Azuma; Yoshio Yazaki
Expression of tumour necrosis factor (TNF) receptor/ligand superfamily co-stimulatory molecules CD40, CD30L, CD27L, and OX40L in murine hearts with chronic ongoing myocarditis caused by coxsackie virus B3.
The Journal of pathology 1999;188(4):423-30.
1999: Nobuyuki Ebihara; T Yokoyama; T Kimura; Kiyoo Nakayasu; Ko Okumura; Atsushi Kanai; Chisei Ra
Anti VLA-4 monoclonal antibody inhibits eosinophil infiltration in allergic conjunctivitis model of guinea pig.
Current eye research 1999;19(1):20-5.
1999: Hisaya Akiba; H Oshima; Kazuyoshi Takeda; M Atsuta; Hiroyasu Nakano; Atsuo Nakajima; C Nohara; Hideo Yagita; Ko Okumura
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7058-66.
1999: K Hattori; Takao Hirano; C Ushiyama; Hiroaki Miyajima; N Yamakawa; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents acute graft-versus-host disease in mice after bone marrow transplantation.
Bone marrow transplantation 1999;23(12):1283-9.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; H Eto; Ko Okumura; Hideo Yagita
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
The Journal of experimental medicine 1999;189(9):1451-60.
1999: Yoshinori Seko; N Takahashi; Hideo Yagita; Ko Okumura; Masahiko Azuma; Yoshio Yazaki
Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on the survival of mice with chronic ongoing myocarditis caused by Coxsackievirus B3.
The Journal of pathology 1999;188(1):107-12.
1999: Yusuke Suzuki; Chisei Ra; Kensuke Saito; Satoshi Horikoshi; S Hasegawa; Toshinao Tsuge; Ko Okumura; Yasuhiko Tomino
Expression and physical association of Fc alpha receptor and Fc receptor gamma chain in human mesangial cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999;14(5):1117-23.
1999: N Tsukada; Tetsuji Kobata; Y Aizawa; Hideo Yagita; Ko Okumura
Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation.
Blood 1999;93(8):2738-47.
1999: S Hasegawa; R Pawankar; K Suzuki; Tatsutoshi Nakahata; Susumu Furukawa; Ko Okumura; Chisei Ra
Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes.
Blood 1999;93(8):2543-51.
1999: K Hattori; Takao Hirano; Hiroaki Miyajima; N Yamakawa; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation.
British journal of haematology 1999;105(1):303-12.
1999: T Kodama; Kazuyoshi Takeda; O Shimozato; Yoshihiro Hayakawa; M Atsuta; K Kobayashi; M Ito; Hideo Yagita; Ko Okumura
Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12.
European journal of immunology 1999;29(4):1390-6.
1999: O Shimozato; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura
Expression of CD30 ligand (CD153) on murine activated T cells.
Biochemical and biophysical research communications 1999;256(3):519-26.
1999: T Takada; K Kato; Hideo Yagita; H Hamada; Ko Okumura
Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice.
Clinical & experimental metastasis 1999;17(2):125-30.
1999: Yoshikazu Ohtsuka; K Naito; Yuichiro Yamashiro; K Yabuta; Ko Okumura; Chisei Ra
Induction of anaphylaxis in mouse intestine by orally administered antigen and its prevention with soluble high affinity receptor for IgE.
Pediatric research 1999;45(3):300-5.
1999: Nobuhiko Kayagaki; Noriko Yamaguchi; Masafumi Nakayama; A Kawasaki; Hisaya Akiba; Ko Okumura; Hideo Yagita
Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2639-47.
1999: T Kawahara; Hideo Yagita; Ko Okumura; Shunji Futagawa
T cell-mediated effector mechanisms in the rejection of allogeneically transplanted hepatocytes.
Transplantation proceedings 1999;31(1-2):830-1.
1999: S Hiraoka; Y Furumoto; H Koseki; Yohtaroh Takagaki; M Taniguchi; Ko Okumura; Chisei Ra
Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement.
International immunology 1999;11(2):199-207.
1999: Ryo Atsuta; K Akiyama; T Shirasawa; Ko Okumura; Yoshinosuke Fukuchi; Chisei Ra
Atopic asthma is dominant in elderly onset asthmatics: possibility for an alteration of mast cell function by aging through Fc receptor expression.
International archives of allergy and immunology 1999;120 Suppl 1():76-81.
1999: N Takahashi; Yoshinori Seko; Masahiko Azuma; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Evidence of cell-mediated cardiac myocyte injury involved in the heart failure of a patient with progressive systemic sclerosis.
Japanese circulation journal 1999;63(1):68-72.
1998: Hidenori Yokoi; M Seki; S Okazoe; Ko Okumura; Ginichirou Ichikawa
[The role and expression of CD27/CD70 in tonsil].
Nihon Jibiinkoka Gakkai kaiho 1998;101(12):1423-9.
1998: S Kobayashi; Shigeru Goto; Roger Lord; S Chiba; Frank Vari; Ko Okumura; I Nagaoka
Cytokine expression in hepatocytes of allografted rat livers.
Transplantation proceedings 1998;30(7):2982-3.
1998: Yoshikazu Ohtsuka; Ryuyo Suzuki; Satoru Nagata; Satoshi Oguchi; Toshiaki Shimizu; Yuichiro Yamashiro; Ko Okumura; Chisei Ra
Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine.
Pediatric research 1998;44(5):791-7.
1998: K Seino; Kazuhisa Iwabuchi; Nobuhiko Kayagaki; R Miyata; Isao Nagaoka; A Matsuzawa; K Fukao; Hideo Yagita; Ko Okumura
Chemotactic activity of soluble Fas ligand against phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4484-8.
1998: Hisaya Akiba; M Atsuta; Hideo Yagita; Ko Okumura
Identification of rat OX40 ligand by molecular cloning.
Biochemical and biophysical research communications 1998;251(1):131-6.
1998: Yusuke Suzuki; Isao Shirato; Ko Okumura; J V Ravetch; T Takai; Yasuhiko Tomino; Chisei Ra
Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis.
Kidney international 1998;54(4):1166-74.
1998: T Kawahara; Hideo Yagita; S Kasai; M Sawa; K Kato; Ko Okumura; Shunji Futagawa; M Mito
Allogeneic hepatocyte transplantation: contribution of Fas-Fas ligand interaction to allogeneic hepatocyte rejection.
Journal of gastroenterology and hepatology 1998;13 Suppl():S119-23.
1998: Yoshinori Seko; N Takahashi; Masahiko Azuma; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies.
Circulation research 1998;83(4):463-9.
1998: Atsuo Nakajima; T Kodama; S Morimoto; Miyuki Azuma; Kazuyoshi Takeda; H Oshima; S Yoshino; Hideo Yagita; Ko Okumura
Antitumor effect of CD40 ligand: elicitation of local and systemic antitumor responses by IL-12 and B7.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1901-7.
1998: M Xu; Y Miura; Fumiko Nagao; T Muto; Ko Okumura
[NK cell activity and subsets of truck drivers along with related factors].
Nihon eiseigaku zasshi. Japanese journal of hygiene 1998;53(2):456-62.
1998: C Sekine; Hideo Yagita; N Miyasaka; Ko Okumura
Expression and function of CD40 in rheumatoid arthritis synovium.
The Journal of rheumatology 1998;25(6):1048-53.
1998: K Hattori; Takao Hirano; Hiroaki Miyajima; N Yamakawa; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies.
Blood 1998;91(11):4051-5.
1998: Hisaya Akiba; Hiroyasu Nakano; S Nishinaka; M Shindo; Tetsuji Kobata; M Atsuta; Chikao Morimoto; Carl Ware; NL Malinin; David Wallach; Hideo Yagita; Ko Okumura
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.
The Journal of biological chemistry 1998;273(21):13353-8.
1998: Y Ohtsuka; K Udaka; Y Yamashiro; Hideo Yagita; Ko Okumura
Dystrophin acts as a transplantation rejection antigen in dystrophin-deficient mice: implication for gene therapy.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4635-40.
1998: K Saito; J Sakurai; J Ohata; T Kohsaka; Hiroshi Hashimoto; Ko Okumura; Ryo Abe; Miyuki Azuma
Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4225-31.
1998: K Suzuki; T Hirose; Hironori Matsuda; S Hasegawa; Ko Okumura; Chisei Ra
The Fc receptor (FcR) gamma subunit is essential for IgE-binding activity of cell-surface expressed chimeric receptor molecules constructed from human high-affinity IgE receptor (Fc epsilon RI) alpha and FcR gamma subunits.
Molecular immunology 1998;35(5):259-70.
1998: H Oshima; Hiroyasu Nakano; C Nohara; Tetsuji Kobata; A Nakajima; N A Jenkins; D J Gilbert; N G Copeland; T Muto; Hideo Yagita; Ko Okumura
Characterization of murine CD70 by molecular cloning and mAb.
International immunology 1998;10(4):517-26.
1998: Hiroyasu Nakano; M Shindo; Sachiko Sakon; S Nishinaka; M Mihara; Hideo Yagita; Ko Okumura
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3537-42.
1998: Yoshinori Seko; N Takahashi; Masahiko Azuma; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on murine acute myocarditis caused by coxsackievirus B3.
Circulation research 1998;82(5):613-8.
1998: M Shindo; Hiroyasu Nakano; Hidehito Kuroyanagi; Takuji Shirasawa; M Mihara; D J Gilbert; N A Jenkins; N G Copeland; Hideo Yagita; Ko Okumura
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Biochemical and biophysical research communications 1998;244(1):285-92.
1998: S Mogi; T Ebata; Y Setoguchi; M Fujime; Y Heike; T Kohsaka; H Yagita; Ko Okumura; Miyuki Azuma
Efficient generation of autologous peripheral blood-derived cytotoxic T lymphocytes against poorly immunogenic human tumors using recombinant CD80-adenovirus together with interleukin 12 and interleukin 2.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):713-20.
1998: Yoshinori Seko; N Takahashi; Shigeru Ishiyama; Toshiro Nishikawa; Takeshi Kasajima; Michiaki Hiroe; Shin Suzuki; Sugao Ishiwata; S Kawai; Masahiko Azuma; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Expression of costimulatory molecules B7-1, B7-2, and CD40 in the heart of patients with acute myocarditis and dilated cardiomyopathy.
Circulation 1998;97(7):637-9.
1998: M Shindo; Hiroyasu Nakano; Sachiko Sakon; Hideo Yagita; M Mihara; Ko Okumura
Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.
Cytogenetics and cell genetics 1998;82(1-2):32-3.
1997: Yoshinori Seko; Osamu Sato; A Takagi; Yusuke Tada; H Matsuo; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Perforin-secreting killer cell infiltration in the aortic tissue of patients with atherosclerotic aortic aneurysm.
Japanese circulation journal 1997;61(12):965-70.
1997: Kenichiro Seino; Nobuhiko Kayagaki; N Tsukada; K Fukao; Hideo Yagita; Ko Okumura
Transplantation of CD95 ligand-expressing grafts: influence of transplantation site and difficulty in protecting allo- and xenografts.
Transplantation 1997;64(7):1050-4.
1997: Chiharu Yamaji; Takao Hirano; Hiroaki Miyajima; Hiroshi Hashimoto; Ko Okumura; Zoltan Ovary
Anti-Thy-1 antibody provokes reverse passive cutaneous anaphylaxis-like reactions.
International archives of allergy and immunology 1997;114(2):161-6.
1997: T Kawahara; Shinichi Kasai; Hideo Yagita; M Sawa; K Kato; M Azuma; A Nakajima; Ko Okumura; Shunji Futagawa; M Mito
Critical role of Fas/Fas ligand interaction in CD28-independent pathway of allogeneic murine hepatocyte rejection.
Hepatology (Baltimore, Md.) 1997;26(4):944-8.
1997: K Seino; N Kayagaki; Kazuyoshi Takeda; K Fukao; Ko Okumura; Hideo Yagita
Contribution of Fas ligand to T cell-mediated hepatic injury in mice.
Gastroenterology 1997;113(4):1315-22.
1997: Yoshinori Seko; N Takahashi; Hideo Yagita; Ko Okumura; Yoshio Yazaki
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3.
The Journal of pathology 1997;183(1):105-8.
1997: Naoto Hirano; Tokiharu Takahashi; T Takahashi; Masahiko Azuma; Ko Okumura; Yoshio Yazaki; Hideo Yagita; Hisamura Hirai
Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80)-transduced leukemic cells.
Human gene therapy 1997;8(11):1375-84.
1997: K Hattori; Takao Hirano; C Ushiyama; Hiroaki Miyajima; N Yamakawa; T Ebata; Y Wada; S Ikeda; K Yoshino; Masatoshi Tateno; Kazuo Oshimi; Nobuhiko Kayagaki; Hideo Yagita; Ko Okumura
A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice.
Blood 1997;90(2):542-8.
1997: Keiko Maeda; T Sato; Miyuki Azuma; Hideo Yagita; Ko Okumura
Characterization of rat CD80 and CD86 by molecular cloning and mAb.
International immunology 1997;9(7):993-1000.
1997: Hiroshi Kaneko; Takashi Hishikawa; Iwao Sekigawa; Hiroshi Hashimoto; Ko Okumura; Y Kaneko
Role of tumour necrosis factor-alpha (TNF-alpha) in the induction of HIV-1 gp120-mediated CD4+ T cell anergy.
Clinical and experimental immunology 1997;109(1):41-6.
1997: A Enomoto; K Kato; Hideo Yagita; Ko Okumura
Adoptive transfer of cytotoxic T lymphocytes induced by CD86-transfected tumor cells suppresses multi-organ metastases of C1300 neuroblastoma in mice.
Cancer immunology, immunotherapy : CII 1997;44(4):204-10.
1997: T Kawahara; Shinichi Kasai; Hideo Yagita; K Kato; M Sawa; A Nakajima; M Azuma; Ko Okumura; Shunji Futagawa; M Mito
Involvement of Fas and Fas ligand interaction in allogeneic hepatocyte rejection in the spleen.
Transplantation proceedings 1997;29(4):2187-8.
1997: Kazuhisa Nozawa; N Kayagaki; Yoshiaki Tokano; Hideo Yagita; Ko Okumura; H Hasimoto
Soluble Fas (APO-1, CD95) and soluble Fas ligand in rheumatic diseases.
Arthritis and rheumatism 1997;40(6):1126-9.
1997: Hiroyasu Nakano; M Shindo; K Yamada; M C Yoshida; SM Santee; Carl Ware; N A Jenkins; D J Gilbert; Hideo Yagita; N C Copeland; Ko Okumura
Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.
Genomics 1997;42(1):26-32.
1997: Atsuo Nakajima; N Watanabe; S Yoshino; Hideo Yagita; Ko Okumura; Miyuki Azuma
Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.
International immunology 1997;9(5):637-44.
1997: N Kayagaki; N Yamaguchi; Fumiko Nagao; S Matsuo; H Maeda; Ko Okumura; Hideo Yagita
Polymorphism of murine Fas ligand that affects the biological activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3914-9.
1997: K Kato; Ko Okumura; Hideo Yagita
Immunoregulation by B7 and IL-12 gene transfer.
Leukemia 1997;11 Suppl 3():572-6.
1997: R Pawankar; M Okuda; H Yssel; Ko Okumura; Chisei Ra
Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells.
The Journal of clinical investigation 1997;99(7):1492-9.
1997: Fumiko Nagao; T Yabe; L Lin; K Tokunaga; T Juji; Ko Okumura
Japanese population does not manifest significant association between low NK activity and HLA-B(C) locus homozygosity.
Human immunology 1997;53(1):17-22.
1997: H Sagara; Hironori Matsuda; N Wada; Hideo Yagita; T Fukuda; Ko Okumura; S Makino; Chisei Ra
A monoclonal antibody against very late activation antigen-4 inhibits eosinophil accumulation and late asthmatic response in a guinea pig model of asthma.
International archives of allergy and immunology 1997;112(3):287-94.
1997: Yoshikazu Tsuzuki; Soichiro Miura; I Kurose; Makoto Suematsu; Hajime Higuchi; T Shigematsu; H Kimura; H Serizawa; Ryota Hokari; Yasutada Akiba; H Yagita; Ko Okumura; P Tso; D Neil Granger; Hiromasa Ishii
Enhanced lymphocyte interaction in postcapillary venules of Peyer's patches during fat absorption in rats.
Gastroenterology 1997;112(3):813-25.
1997: Takuma Kato; T Morokata; Osamu Igarashi; S T Yee; Manabu Inobe; Toshimitsu Uede; Masahiko Azuma; Ko Okumura; H Nariuchi
Costimulatory effect of IL-12 on the activation of naive, memory CD4+ T cells, and Th1 clone.
Cellular immunology 1997;176(1):50-8.
1997: Kenichiro Seino; Nobuhiko Kayagaki; K Fukao; Ko Okumura; Hideo Yagita
Rejection of Fas ligand-expressing grafts.
Transplantation proceedings 1997;29(1-2):1092-3.
1997: Yoshiaki Tokano; S Endo; F Hayashi; S Harada; Shigeto Kobayashi; Hiroshi Tsuda; Yoshinari Takasaki; Y Kyogoku; Y Arata; Ko Okumura; Hiroshi Hashimoto; Sachiko Hirose
A hidden immunoglobulin G2 in patients with rheumatoid arthritis detected by nuclear magnetic resonance.
The Journal of rheumatology 1997;24(2):275-81.
1997: K Seino; Nobuhiko Kayagaki; Ko Okumura; Hideo Yagita
Antitumor effect of locally produced CD95 ligand.
Nature medicine 1997;3(2):165-70.
1997: Atsuo Nakajima; Sachiko Hirose; Hideo Yagita; Ko Okumura
Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1466-72.
1997: Shin Aizawa; Hiroyasu Nakano; Takaomi Ishida; Ryouichi Horie; M Nagai; Kousei Ito; Hideo Yagita; Ko Okumura; Jun-Ichiro Inoue; Tomomi Watanabe
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.
The Journal of biological chemistry 1997;272(4):2042-5.
1997: Hisashi Bashuda; Kenichiro Seino; C Ra; Hideo Yagita; Ko Okumura
Lack of cognate help by CD4+ T cells and anergy of CD8+ T cells are the principal mechanisms for anti-leukocyte function-associated antigen-1/intercellular adhesion molecule-1-induced cardiac allograft tolerance.
Transplantation 1997;63(1):113-8.
1997: Yoshiaki Tokano; Shinji Morimoto; Takashi Hishikawa; A Murashima; M Abe; Iwao Sekigawa; Yoshinari Takasaki; Hiroshi Hashimoto; Ko Okumura; T Shirai; Sachiko Hirose
Subsets of activated T cells in patients with systemic lupus erythematosus: the relation to cell cycle.
Scandinavian journal of rheumatology 1997;26(1):37-42.