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Kenji Okumura

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Xian Wu Cheng; Lina Hu; Nobuo Ikeda; Hideki Ishii; Ryosuke Kikuchi; Masafumi Kuzuya; Kenji Okumura; Rei Shibata; Ryotaro Takahashi; Daiji Yoshikawa; Toyoaki Murohara
Circulating cathepsin K as a potential novel biomarker of coronary artery disease.
Xian Wu Cheng; Zhe Huang; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara
Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications.
Xian Wu Cheng; Haizhen Song; Takeshi Sasaki; Lina Hu; Aiko Inoue; Yasuko K Bando; Guo-Ping Shi; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara
Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

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2013: Xian Wu Cheng; Lina Hu; Nobuo Ikeda; Hideki Ishii; Ryosuke Kikuchi; Masafumi Kuzuya; Kenji Okumura; Rei Shibata; Ryotaro Takahashi; Daiji Yoshikawa; Toyoaki Murohara
Circulating cathepsin K as a potential novel biomarker of coronary artery disease.
Atherosclerosis 2013;228(1):211-6.
2011: Xian Wu Cheng; Zhe Huang; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara
Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications.
Hypertension 2011;58(6):978-86.
2011: Xian Wu Cheng; Haizhen Song; Takeshi Sasaki; Lina Hu; Aiko Inoue; Yasuko K Bando; Guo-Ping Shi; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara
Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
Hypertension 2011;57(5):981-9.
2011: Xian Wu Cheng; Masafumi Kuzuya; Takeshi Sasaki; Aiko Inoue; Lina Hu; Haizhen Song; Zhe Huang; Ping Li; Kyosuke Takeshita; Akihiro Hirashiki; Kohji Sato; Guo-Ping Shi; Kenji Okumura; Toyoaki Murohara
Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.
Journal of hypertension 2011;29(3):542-52.
2010: Ryuji Kubota; Yasushi Numaguchi; Masakazu Ishii; Manabu Niwa; Kenji Okumura; Keiji Naruse; Toyoaki Murohara
Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1α.
Biochemical and biophysical research communications 2010;402(2):396-401.
2010: Ryuichiro Murakami; Hisashi Murakami; Hiroki Kataoka; Xian Wu Cheng; Ryotaro Takahashi; Yasushi Numaguchi; Toyoaki Murohara; Kenji Okumura
Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.
Life sciences 2010;87(15-16):495-500.
2010: Xian Wu Cheng; Masafumi Kuzuya; Weon Kim; Haizhen Song; Lina Hu; Aiko Inoue; Kae Nakamura; Qun Di; Takeshi Sasaki; Michitaka Tsuzuki; Guo-Ping Shi; Kenji Okumura; Toyoaki Murohara
Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age.
Circulation 2010;122(7):707-16.
2010: Kenji Okumura; Xian Wu Cheng
Endothelial function for the evaluation of anti-atherosclerotic drugs.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(8):780-1.
2010: Takao Nishizawa; Xian Wu Cheng; Zhehu Jin; Koji Obata; Kohzo Nagata; Akihiro Hirashiki; Takeshi Sasaki; Akiko Noda; Kyosuke Takeshita; Hideo Izawa; Guo-Ping Shi; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara
Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.
Journal of hypertension 2010;28(7):1515-26.
2010: Hiroki Kataoka; Ryuichiro Murakami; Yasushi Numaguchi; Kenji Okumura; Toyoaki Murohara
Angiotensin II type 1 receptor blockers prevent tumor necrosis factor-alpha-mediated endothelial nitric oxide synthase reduction and superoxide production in human umbilical vein endothelial cells.
European journal of pharmacology 2010;636(1-3):36-41.
2010: Akiko Imamura; Ryuichiro Murakami; Ryotaro Takahashi; Xian Wu Cheng; Yasushi Numaguchi; Toyoaki Murohara; Kenji Okumura
Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.
Metabolism: clinical and experimental 2010;59(5):728-33.
2010: Osamu Yoshida; Takahisa Kondo; Yasuko Kureishi-Bando; Tomonori Sugiura; Kengo Maeda; Kenji Okumura; Toyoaki Murohara
Pitavastatin, an HMG-CoA reductase inhibitor, ameliorates endothelial function in chronic smokers.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(1):195-202.
2009: Takashi Yamada; Kohzo Nagata; Xian Wu Cheng; Koji Obata; Masako Saka; Masaaki Miyachi; Keiko Naruse; Takao Nishizawa; Akiko Noda; Hideo Izawa; Masafumi Kuzuya; Kenji Okumura; Toyoaki Murohara; Mitsuhiro Yokota
Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.
European journal of pharmacology 2009;615(1-3):163-70.
2009: Xian Wu Cheng; Kenji Okumura; Masafumi Kuzuya; Zhehu Jin; Kohzo Nagata; Koji Obata; Aiko Inoue; Akihiro Hirashiki; Kyosuke Takeshita; Kazumasa Unno; Ken Harada; Guo-Ping Shi; Mitsuhiro Yokota; Toyoaki Murohara
Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers.
Journal of cardiovascular pharmacology 2009;54(1):47-56.
2009: Manabu Miura; Yasushi Numaguchi; Masakazu Ishii; Ryuji Kubota; Toyonari Takeuchi; Akiko Imamura; Ryuichiro Murakami; Takahisa Kondo; Kenji Okumura; Toyoaki Murohara
Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(7):1324-9.
2009: Shuji Morikawa; Takahito Sone; Hideyuki Tsuboi; Hiroaki Mukawa; Itsuro Morishima; Michitaka Uesugi; Yasuhiro Morita; Yasushi Numaguchi; Kenji Okumura; Toyoaki Murohara
Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide.
Journal of the American College of Cardiology 2009;53(12):1040-6.
2008: Itsuro Morishima; Takahito Sone; Hideyuki Tsuboi; Hiroaki Mukawa; Michitaka Uesugi; Shuji Morikawa; Kensuke Takagi; Toru Niwa; Yasuhiro Morita; Ryuichiro Murakami; Yasushi Numaguchi; Toyoaki Murohara; Kenji Okumura
Risk stratification of patients with prior myocardial infarction and advanced left ventricular dysfunction by gated myocardial perfusion SPECT imaging.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2008;15(5):631-7.
2008: Xian Wu Cheng; Toyoaki Murohara; Masafumi Kuzuya; Hideo Izawa; Takeshi Sasaki; Koji Obata; Kohzo Nagata; Takao Nishizawa; Masakazu Kobayashi; Takashi Yamada; Weon Kim; Kohji Sato; Guo-Ping Shi; Kenji Okumura; Mitsuhiro Yokota
Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.
The American journal of pathology 2008;173(2):358-69.
2008: Akiko Imamura; Ryotaro Takahashi; Ryuichiro Murakami; Hiroki Kataoka; Xian Wu Cheng; Yasushi Numaguchi; Toyoaki Murohara; Kenji Okumura
The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(2):189-95.
2008: Ping Li; Takahisa Kondo; Yasushi Numaguchi; Koichi Kobayashi; Mika Aoki; Natsuo Inoue; Kenji Okumura; Toyoaki Murohara
Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis.
Hypertension 2008;51(2):252-8.
2007: Shingo Ai; Xian Wu Cheng; Aiko Inoue; Kae Nakamura; Kenji Okumura; Akihisa Iguchi; Toyoaki Murohara; Masafumi Kuzuya
Angiogenic activity of bFGF and VEGF suppressed by proteolytic cleavage by neutrophil elastase.
Biochemical and biophysical research communications 2007;364(2):395-401.
2007: Hajime Imai; Yasushi Numaguchi; Masakazu Ishii; Ryuji Kubota; Kazuhiko Yokouchi; Yasuhiro Ogawa; Takahisa Kondo; Kenji Okumura; Toyoaki Murohara
Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression.
Atherosclerosis 2007;195(2):322-32.
2007: Masayuki Torigoe; Hideo Matsui; Yasuhiro Ogawa; Hisashi Murakami; Ryuichiro Murakami; Xian Wu Cheng; Yasushi Numaguchi; Toyoaki Murohara; Kenji Okumura
Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men.
Clinical endocrinology 2007;67(2):276-81.
2007: Yuzo Hayashi; Kenji Okumura; Hideo Matsui; Akiko Imamura; Manabu Miura; Ryotaro Takahashi; Ryuichiro Murakami; Yasuhiro Ogawa; Yasushi Numaguchi; Toyoaki Murohara
Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2007;56(5):608-13.
2007: Xian Wu Cheng; Masafumi Kuzuya; Kae Nakamura; Keiko Maeda; Michitaka Tsuzuki; Weon Kim; Takeshi Sasaki; Zexuan Liu; Natsuo Inoue; Takahisa Kondo; Hai Jin; Yasushi Numaguchi; Kenji Okumura; Mitsuhiro Yokota; Akihisa Iguchi; Toyoaki Murohara
Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metalloproteinase 2-deficient mice.
Circulation research 2007;100(6):904-13.
2006: Kazuhiko Yokouchi; Yasushi Numaguchi; Ryuji Kubota; Masakazu Ishii; Hajime Imai; Ryuichiro Murakami; Yasuhiro Ogawa; Takahisa Kondo; Kenji Okumura; Donald Ingber; Toyoaki Murohara
l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2231-7.
2006: Hideo Izawa; Takahisa Kondo; Akihiko Usui; Koji Yamamoto; Satoshi Shintani; Yasuya Inden; Satoshi Isobe; Kazumasa Unno; Masahiro Kajiguchi; Tomoko Kato; Akiko Noda; Kenji Okumura; Tomoki Naoe; Junki Takamatsu; Kimihiro Komori; Yuichi Ueda; Toyoaki Murohara
Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(9):1180-3.
2006: Akiko Imamura; Kenji Okumura; Yasuhiro Ogawa; Ryuichiro Murakami; Masayuki Torigoe; Yasushi Numaguchi; Toyoaki Murohara
Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese.
Clinica chimica acta; international journal of clinical chemistry 2006;371(1-2):66-70.
2006: Toshihisa Hirai; Kenji Okumura; Yasuhiro Nishimoto; Takanori Shumiya; Ryuichiro Murakami; Ryotaro Takahashi; Toru Asai; Hisashi Murakami; Yasushi Numaguchi; Hideo Matsui; Toyoaki Murohara
Upregulation of renal eNOS by high-sodium diet facilitates hypertension in doxorubicin-treated rats through enhanced oxidative stress.
Toxicology 2006;225(2-3):81-9.
2006: Yasushi Numaguchi; Takahito Sone; Kenji Okumura; Masakazu Ishii; Yasuhiro Morita; Ryuji Kubota; Kazuhiko Yokouchi; Hajime Imai; Mitsunori Harada; Hiroyuki Osanai; Takahisa Kondo; Toyoaki Murohara
The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.
Circulation 2006;114(1 Suppl):I114-9.
2006: Toru Asai; Kenji Okumura; Ryotaro Takahashi; Hideo Matsui; Yasushi Numaguchi; Hisashi Murakami; Ryuichiro Murakami; Toyoaki Murohara
Combined therapy with PPARalpha agonist and L-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency.
Cardiovascular research 2006;70(3):566-77.
2006: Akihiro Hirashiki; Hideo Izawa; Fuji Somura; Koji Obata; Tomoko Kato; Takao Nishizawa; Akira Yamada; Hiroyuki Asano; Satoru Ohshima; Akiko Noda; Shigeo Iino; Kohzo Nagata; Kenji Okumura; Toyoaki Murohara; Mitsuhiro Yokota
Prognostic value of pacing-induced mechanical alternans in patients with mild-to-moderate idiopathic dilated cardiomyopathy in sinus rhythm.
Journal of the American College of Cardiology 2006;47(7):1382-9.
2006: Hisashi Murakami; Ryuichiro Murakami; Fukushi Kambe; Xia Cao; Ryotaro Takahashi; Toru Asai; Toshihisa Hirai; Yasushi Numaguchi; Kenji Okumura; Hisao Seo; Toyoaki Murohara
Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC.
Biochemical and biophysical research communications 2006;341(4):973-8.
2005: Satoru Ohshima; Satoshi Isobe; Hideo Izawa; Mamoru Nanasato; Akitada Ando; Akira Yamada; Kiyoyasu Yamada; Tomoko S Kato; Koji Obata; Akiko Noda; Takao Nishizawa; Katsuhiko Kato; Kohzo Nagata; Kenji Okumura; Toyoaki Murohara; Mitsuhiro Yokota
Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients.
Journal of the American College of Cardiology 2005;46(11):2061-8.
2005: Mejeong Lee; Mika Aoki; Takahisa Kondo; Koichi Kobayashi; Kenji Okumura; Kimihiro Komori; Toyoaki Murohara
Therapeutic angiogenesis with intramuscular injection of low-dose recombinant granulocyte-colony stimulating factor.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2535-41.
2005: Hideo Izawa; Toyoaki Murohara; Kohzo Nagata; Satoshi Isobe; Hiroyuki Asano; Tetsuya Amano; Sahoko Ichihara; Tomoko Kato; Satoru Ohshima; Yosuke Murase; Shigeo Iino; Koji Obata; Akiko Noda; Kenji Okumura; Mitsuhiro Yokota
Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study.
Circulation 2005;112(19):2940-5.
2005: Michitaka Tsuzuki; Itsuro Morishima; Tomohiro Yoshida; Yuzo Hayashi; Manabu Miura; Toshihisa Hirai; Toru Asai; Yasushi Numaguchi; Takahito Sone; Hideo Matsui; Kenji Okumura; Toyoaki Murohara
Inverse correlation between soluble CD40 ligand and soluble CD40 is absent in patients with unstable angina.
Heart and vessels 2005;20(6):245-50.
2005: Ryotaro Takahashi; Kenji Okumura; Toru Asai; Toshihisa Hirai; Hisashi Murakami; Ryuichiro Murakami; Yasushi Numaguchi; Hideo Matsui; Masafumi Ito; Toyoaki Murohara
Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency.
Cardiovascular research 2005;68(2):213-23.
2005: Kenji Okumura; Akiko Imamura; Ryuichiro Murakami; Yasushi Numaguchi; Hideo Matsui; Murohara Toyoaki
Endothelial function and early atherosclerotic changes.
Future cardiology 2005;1(4):501-8.
2004: Akira Kimura; Kenji Okumura; Shinji Mokuno; Yasushi Numaguchi; Hideo Matsui; Toyoaki Murohara
Higher viscosity participates in the regulation of coronary flow via nitric oxide and indomethacin-sensitive contracting factor.
Canadian journal of physiology and pharmacology 2004;82(12):1096-102.
2004: Tomofumi Mizuno; Hideo Matsui; Akiko Imamura; Yasushi Numaguchi; Kazuyoshi Sakai; Toyoaki Murohara; Kenji Okumura
Insulin resistance increases circulating malondialdehyde-modified LDL and impairs endothelial function in healthy young men.
International journal of cardiology 2004;97(3):455-61.
2004: Akiko Imamura; Kenji Okumura; Hideo Matsui; Tomofumi Mizuno; Yasuhiro Ogawa; Hajime Imai; Yasushi Numaguchi; Kazuyoshi Sakai; Toyoaki Murohara
Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.
The Canadian journal of cardiology 2004;20(12):1229-34.
2004: Yoko Kitamura; Kenji Okumura; Akiko Imamura; Tomofumi Mizuno; Michitaka Tsuzuki; Yasushi Numaguchi; Hideo Matsui; Toyoaki Murohara
Association of plasminogen activator inhibitor-1 4G/5G gene polymorphism with variations in the LDL particle size in healthy Japanese men.
Clinica chimica acta; international journal of clinical chemistry 2004;347(1-2):209-16.
2004: Yasushi Numaguchi; Kenji Okumura; Mitsunori Harada; Keiko Naruse; Michiharu Yamada; Hiroyuki Osanai; Hideo Matsui; Masafumi Ito; Toyoaki Murohara
Catheter-based prostacyclin synthase gene transfer prevents in-stent restenosis in rabbit atheromatous arteries.
Cardiovascular research 2004;61(1):177-85.
2003: Junichiro Kondo; Takahito Sone; Hideyuki Tsuboi; Hiroaki Mukawa; Itsuro Morishima; Michitaka Uesugi; Tomohiro Kono; Takashi Kosaka; Tomohiro Yoshida; Yasushi Numaguchi; Hideo Matsui; Toyoaki Murohara; Kenji Okumura
Effects of low-dose angiotensin II receptor blocker candesartan on cardiovascular events in patients with coronary artery disease.
American heart journal 2003;146(6):E20.
2003: Ryuichiro Murakami; Fukushi Kambe; Hirohito Mitsuyama; Kenji Okumura; Toyoaki Murohara; Satoru Niwata; Ryohei Yamamoto; Hisao Seo
Cyclosporin A enhances interleukin-8 expression by inducing activator protein-1 in human aortic smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2034-40.
2003: Ryotaro Takahashi; Kenji Okumura; Hideo Matsui; Yoshihiro Saburi; Hiroki Kamiya; Kenichiro Matsubara; Toru Asai; Masafumi Ito; Toyoaki Murohara
Impact of alpha-tocopherol on cardiac hypertrophy due to energy metabolism disorder: the involvement of 1,2-diacylglycerol.
Cardiovascular research 2003;58(3):565-74.
2003: Kenji Okumura; Hideo Matsui; Yasuhiro Ogawa; Ryotaro Takahashi; Kenichiro Matsubara; Hajime Imai; Akiko Imamura; Tomofumi Mizuno; Michitaka Tsuzuki; Yoko Kitamura
The polymorphism of the beta3-adrenergic receptor gene is associated with reduced low-density lipoprotein particle size.
Metabolism: clinical and experimental 2003;52(3):356-61.
2003: Takahito Tomida; Yasushi Numaguchi; Yasuhiro Nishimoto; Michitaka Tsuzuki; Yuzo Hayashi; Hajime Imai; Hideo Matsui; Kenji Okumura
Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats.
Journal of hypertension 2003;21(3):601-9.
2003: Hiroaki Mukawa; Yukio Toki; Yutaka Miyazaki; Hideo Matsui; Kenji Okumura; Takayuki Ito
Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(1):89-95.
2003: Yoshihiro Saburi; Kenji Okumura; Hideo Matsui; Kazunori Hayashi; Hiroki Kamiya; Ryotaro Takahashi; Kenichiro Matsubara; Masafumi Ito
Changes in distinct species of 1,2-diacylglycerol in cardiac hypertrophy due to energy metabolic disorder.
Cardiovascular research 2003;57(1):92-100.
2002: Yasuhiro Ogawa; Kenji Okumura; Hideo Matsui; Yasumasa Fukami; Yoshihiro Saburi; Hajime Iami; Tomofumi Mizuno; Yasuhiro Nishimoto
Relaxant properties mediated by nitroglycerin in aortic coarctation hypertensive rats.
Heart and vessels 2002;17(2):69-73.
2002: Tomomichi Suzuki; Kenji Okumura; Takahito Sone; Tai Kosokabe; Hideyuki Tsuboi; Junichiro Kondo; Hiroaki Mukawa; Hiroki Kamiya; Takahito Tomida; Hajime Imai; Hideo Matsui; Tetsuo Hayakawa
The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis.
International journal of cardiology 2002;86(1):71-6.
2002: Masahiro Inoue; Yuko Fujii; Keiko Furukawa; Masahiko Okada; Kenji Okumura; Tetsuo Hayakawa; Koichi Furukawa; Yasuo Sugiura
Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside.
The Journal of biological chemistry 2002;277(33):29881-8.
2002: Yasuhiro Nishimoto; Takahito Tomida; Hideo Matsui; Takayuki Ito; Kenji Okumura
Decrease in renal medullary endothelial nitric oxide synthase of fructose-fed, salt-sensitive hypertensive rats.
Hypertension 2002;40(2):190-4.
2002: Takanori Uchida; Kenji Okumura; Takayuki Ito; Hiroki Kamiya; Yasuhiro Nishimoto; Michiharu Yamada; Takahito Tomida; Hideo Matsui; Tetsuo Hayakawa
Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats.
Clinical and experimental pharmacology & physiology 2002;29(5-6):381-5.
2002: Kenji Okumura; Takahito Sone; Junichiro Kondo; Hideyuki Tsuboi; Hiroaki Mukawa; Michitaka Tsuzuki; Hajime Imai; Hiroki Kamiya; Yukio Mabuchi; Hideo Matsui; Tetsuo Hayakawa
Quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(4):311-6.
2002: Kenji Okumura; Hideo Matsui; Hiroki Kamiya; Yoshihiro Saburi; Kazunori Hayashi; Tetsuo Hayakawa
Differential effect of two common polymorphisms in the cholesteryl ester transfer protein gene on low-density lipoprotein particle size.
Atherosclerosis 2002;161(2):425-31.
2002: Hideo Matsui; Itsuro Morishima; Kazunori Hayashi; Hiroki Kamiya; Yoshihiro Saburi; Kenji Okumura
Dietary fish oil does not prevent doxorubicin-induced cardiomyopathy in rats.
The Canadian journal of cardiology 2002;18(3):279-86.
2002: Itsuro Morishima; Takahito Sone; Hideyuki Tsuboi; Junichiro Kondo; Hiroaki Mukawa; Hiroki Kamiya; Nobuyuki Hieda; Kenji Okumura
Plasma C-reactive protein predicts left ventricular remodeling and function after a first acute anterior wall myocardial infarction treated with coronary angioplasty: comparison with brain natriuretic peptide.
Clinical cardiology 2002;25(3):112-6.
2002: Michiharu Yamada; Yasushi Numaguchi; Kenji Okumura; Mitsunori Harada; Keiko Naruse; Hideo Matsui; Takayuki Ito; Tetsuo Hayakawa
Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):256-62.
2001: Hiroki Kamiya; Kenji Okumura; Masafumi Ito; Yoshihiro Saburi; Takahito Tomida; Kazunori Hayashi; Hideo Matsui; Tetsuo Hayakawa
Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder.
The Canadian journal of cardiology 2001;17(12):1292-8.
2001: Hiroki Kamiya; Kenji Okumura; Masafumi Ito; Hideo Matsui; Yoshihiro Saburi; Kazunori Hayashi; Tetsuo Hayakawa
Antioxidant changes in the hypertrophied heart due to energy metabolic disorder.
Basic research in cardiology 2001;96(5):431-8.
2001: Takahito Tomida; Yasushi Numaguchi; Hideo Matsui; Yukio Toki; Takayuki Ito; Kenji Okumura; Tetsuo Hayakawa
Altered expression of prostacyclin synthase in a subset of the thick ascending limb cells and mesangial cells in 5/6-nephrectomized rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(4):411-9.
2001: Shinji Mokuno; Takayuki Ito; Yasushi Numaguchi; Hideo Matsui; Yukio Toki; Kenji Okumura; Tetsuo Hayakawa
Impaired nitric oxide production and enhanced autoregulation of coronary circulation in young spontaneously hypertensive rats at prehypertensive stage.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(4):395-401.
2001: K Kawakami; Kenji Okumura; Hideo Matsui; Takahito Tomida; Hiroki Kamiya; Hiroyuki Osanai; Y Sakai; H Kanayama; Tetsuo Hayakawa
The apolipoprotein E genotype influences the risk for vasospastic angina.
The Canadian journal of cardiology 2001;17(6):660-6.
2001: Tai Kosokabe; Kenji Okumura; Takahito Sone; Junichiro Kondo; Hideyuki Tsuboi; Hiroaki Mukawa; Takahito Tomida; T Suzuki; Hiroki Kamiya; Hideo Matsui; Tetsuo Hayakawa
Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting.
Circulation 2001;103(16):2048-54.
2001: Kazunori Hayashi; Kenji Okumura; Hideo Matsui; K Murase; Hiroki Kamiya; Yoshihiro Saburi; Yasushi Numaguchi; Yukio Toki; Tetsuo Hayakawa
Involvement of 1,2-diacylglycerol in improvement of heart function by etomoxir in diabetic rats.
Life sciences 2001;68(13):1515-26.
2001: Junichiro Kondo; Takahito Sone; Hideyuki Tsuboi; Hiroaki Mukawa; Tai Kosokabe; Michitaka Tsuzuki; Takahito Tomida; T Suzuki; Hiroki Kamiya; K Hayashi; Hideo Matsui; Kenji Okumura
Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound.
The American journal of cardiology 2001;87(4):443-5, A6.
2001: Kenji Okumura; Kazunori Hayashi; K Murase; Hideo Matsui; Yukio Toki
Alterations in 1,2-diacylglycerols and ceramides in diabetic rat heart.
Advances in experimental medicine and biology 2001;498():167-73.
2001: T Uchida; Yukio Toki; Yasumasa Fukami; H Kamiya; Hideo Matsui; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Relative importance of calcium-activated potassium channels in nipradilol-induced aortic relaxation in rats.
Arzneimittel-Forschung 2001;51(5):383-6.
2000: Hiroyuki Osanai; Kenji Okumura; M Hayakawa; Mitsunori Harada; Yasushi Numaguchi; Shinji Mokuno; K Murase; Hideo Matsui; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa
Ascorbic acid improves postischemic vasodilatation impaired by infusion of soybean oil into canine iliac artery.
Journal of cardiovascular pharmacology 2000;36(6):687-92.
2000: A Iseki; Fukushi Kambe; Kenji Okumura; Tetsuo Hayakawa; Hisao Seo
Regulation of thyroid follicular cell function by intracellular redox-active copper.
Endocrinology 2000;141(12):4373-82.
2000: I Morishima; Takahito Sone; Kenji Okumura; Hideyuki Tsuboi; Junichiro Kondo; Hiroaki Mukawa; H Matsui; Yukio Toki; T Ito; T Hayakawa
Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction.
Journal of the American College of Cardiology 2000;36(4):1202-9.
2000: A Iseki; Fukushi Kambe; Kenji Okumura; S Niwata; R Yamamoto; Tetsuo Hayakawa; Hisao Seo
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells.
Biochemical and biophysical research communications 2000;276(1):88-92.
2000: M Hayakawa; Takayuki Ito; Hiroyuki Osanai; Mitsunori Harada; Yasushi Numaguchi; Shinji Mokuno; K Murase; Yukio Toki; Kenji Okumura; Tetsuo Hayakawa
Simultaneous intravascular two-dimensional plus Doppler ultrasound is useful for evaluation of postischemic vasodilatation: plasm NOx - levels determined by the Griess method may not reflect the extent of postischemic NO-induced vasodilatation.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(4):331-8.
2000: Hiroki Kamiya; Kenji Okumura; Takahito Sone; Hideyuki Tsuboi; Junichiro Kondo; Hiroaki Mukawa; Hideo Matsui; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa
Plasma adrenomedullin levels in the coronary circulation in vasospastic angina pectoris.
The American journal of cardiology 2000;85(5):656-8, A10.
2000: S Mitani; Kenji Okumura; Hideo Matsui; Yukio Toki; H Hashimoto; Takayuki Ito; T Hayakawa
Insulin alters cardiac muscle creatine kinase activity.
Heart and vessels 2000;15(1):23-9.
2000: S Kaneko; Kenji Okumura; Yasushi Numaguchi; Hideo Matsui; K Murase; Shinji Mokuno; I Morishima; K Hira; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa
Melatonin scavenges hydroxyl radical and protects isolated rat hearts from ischemic reperfusion injury.
Life sciences 2000;67(2):101-12.
2000: K Murase; Kenji Okumura; Kazunori Hayashi; Hideo Matsui; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa
Measurements of 1,2-diacylglycerol and ceramide in hearts subjected to ischemic preconditioning.
Life sciences 2000;66(16):1491-500.
1999: Mitsunori Harada; Yukio Toki; Yasushi Numaguchi; Hiroyuki Osanai; Takayuki Ito; Kenji Okumura; Tetsuo Hayakawa
Prostacyclin synthase gene transfer inhibits neointimal formation in rat balloon-injured arteries without bleeding complications.
Cardiovascular research 1999;43(2):481-91.
1999: Kenji Okumura; Hideo Matsui; K Kawakami; Yasushi Numaguchi; S Kaneko; I Morishima; Shinji Mokuno; Yukio Toki; Tetsuo Hayakawa
Relationship between the apolipoprotein E and angiotensin-converting enzyme genotypes and LDL particle size in Japanese subjects.
Clinica chimica acta; international journal of clinical chemistry 1999;285(1-2):91-103.
1999: I Kamekura; Kenji Okumura; Hideo Matsui; K Murase; Shinji Mokuno; Yukio Toki; Y Nakashima; Takayuki Ito
Mechanisms of hypoxic coronary vasodilatation in isolated perfused rat hearts.
Journal of cardiovascular pharmacology 1999;33(6):836-42.
1999: I Morishima; Kenji Okumura; Hideo Matsui; S Kaneko; Yasushi Numaguchi; K Kawakami; Shinji Mokuno; M Hayakawa; Yukio Toki; Takayuki Ito; Tetsuo Hayakawa
Zinc accumulation in adriamycin-induced cardiomyopathy in rats: effects of melatonin, a cardioprotective antioxidant.
Journal of pineal research 1999;26(4):204-10.
1999: Makoto Hibino; Kenji Okumura; Y Iwama; Shinji Mokuno; Hiroyuki Osanai; Hideo Matsui; Yukio Toki; Takayuki Ito
Oxygen-derived free radical-induced vasoconstriction by thromboxane A2 in aorta of the spontaneously hypertensive rat.
Journal of cardiovascular pharmacology 1999;33(4):605-10.
1999: Yasushi Numaguchi; Mitsunori Harada; Hiroyuki Osanai; Kazunori Hayashi; Yukio Toki; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats.
Cardiovascular research 1999;41(3):682-8.
1999: Yasushi Numaguchi; Keiko Naruse; Mitsunori Harada; Hiroyuki Osanai; Shinji Mokuno; K Murase; Hideo Matsui; Yukio Toki; Takayuki Ito; Kenji Okumura; Tetsuo Hayakawa
Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):727-33.
1999: Hideo Matsui; I Morishima; Yasushi Numaguchi; Yukio Toki; Kenji Okumura; Tetsuo Hayakawa
Protective effects of carvedilol against doxorubicin-induced cardiomyopathy in rats.
Life sciences 1999;65(12):1265-74.
1999: Hiroyuki Osanai; Yukio Toki; Y Nakashima; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Reduction of vascular tone by introduction of troglitazone to the canine coronary artery.
Arzneimittel-Forschung 1999;49(1):26-9.
1998: Kenji Okumura; Hideo Matsui; K Kawakami; I Morishima; Yasushi Numaguchi; K Murase; Yukio Toki; T Ito
Modulation of LDL particle size after an oral glucose load is associated with insulin levels.
Clinica chimica acta; international journal of clinical chemistry 1998;276(2):143-55.
1998: A Shimauchi; Yukio Toki; Yasushi Numaguchi; Hiroaki Mukawa; Hideo Matsui; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Short-term treatment with prostaglandin E1 analogue has long-term preventive effects on intimal thickening in balloon-injured rat carotid arteries.
Prostaglandins & other lipid mediators 1998;56(2-3):119-30.
1998: Kenji Okumura; Kazunori Hayashi; I Morishima; K Murase; Hideo Matsui; Yukio Toki; Takayuki Ito
Simultaneous quantitation of ceramides and 1,2-diacylglycerol in tissues by Iatroscan thin-layer chromatography-flame-ionization detection.
Lipids 1998;33(5):529-32.
1998: Yasumasa Fukami; Yukio Toki; Yasushi Numaguchi; Y Nakashima; Hiroaki Mukawa; Hideo Matsui; Kenji Okumura; Takayuki Ito
Nitroglycerin-induced aortic relaxation mediated by calcium-activated potassium channel is markedly diminished in hypertensive rats.
Life sciences 1998;63(12):1047-55.
1998: I Morishima; Hideo Matsui; Hiroaki Mukawa; Kazunori Hayashi; Yukio Toki; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats.
Life sciences 1998;63(7):511-21.
1997: Hiroaki Mukawa; Yukio Toki; A Shimauchi; Hideo Matsui; I Morishima; Kenji Okumura; Takayuki Ito; Tetsuo Hayakawa
Pressure overload per se rather than cardiac angiotensin converting enzyme activity may be important in the development of rat cardiac hypertrophy.
Journal of hypertension 1997;15(9):1027-32.
1997: Hideo Matsui; Kenji Okumura; Hiroaki Mukawa; Makoto Hibino; Yukio Toki; Takayuki Ito
Increased oxysterol contents in diabetic rat hearts: their involvement in diabetic cardiomyopathy.
The Canadian journal of cardiology 1997;13(4):373-9.
1997: Hideo Matsui; Kenji Okumura; K Kawakami; Makoto Hibino; Yukio Toki; Takayuki Ito
Improved insulin sensitivity by bezafibrate in rats: relationship to fatty acid composition of skeletal-muscle triglycerides.
Diabetes 1997;46(3):348-53.
1997: Y Nakashima; Yukio Toki; Yasumasa Fukami; Makoto Hibino; Kenji Okumura; Takayuki Ito
Role of K+ channels in EDHF-dependent relaxation induced by acetylcholine in canine coronary artery.
Heart and vessels 1997;12(6):287-93.
1997: M Shinoda; Yukio Toki; K Murase; Shinji Mokuno; Kenji Okumura; Takayuki Ito
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Life sciences 1997;61(10):997-1007.
1996: Kenji Okumura; Hideo Matsui; K Murase; A Shimauchi; K Shimizu; Yukio Toki; T Ito; T Hayakawa
Insulin increases distinct species of 1,2-diacylglycerol in isolated perfused rat heart.
Metabolism: clinical and experimental 1996;45(6):774-81.
1996: H Matsui; H Hashimoto; A Fukushima; H Kanayama; S Mitani; Yukio Toki; Kenji Okumura; T Ito
MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase.
American heart journal 1996;131(1):24-31.
1995: Kenji Okumura; Hideo Matsui; M Kikuchi; Hiroaki Mukawa; Yukio Toki; T Ito
Triiodothyronine decreases the accumulation of 1,2-diacylglycerol in rat hearts.
The Canadian journal of cardiology 1995;11(7):565-72.
1995: Kenji Okumura; M Kikuchi; Hideo Matsui; K Naruse; K Shimizu; Yukio Toki; H Hashimoto; T Ito
Abnormal arachidonate distribution in low-density lipoprotein and thoracic aorta in hyperinsulinemia.
Metabolism: clinical and experimental 1995;44(6):806-11.
1995: K Ishikawa; H Hashimoto; S Mitani; Yukio Toki; Kenji Okumura; T Ito
Enalapril improves heart failure induced by monocrotaline without reducing pulmonary hypertension in rats: roles of preserved myocardial creatine kinase and lactate dehydrogenase isoenzymes.
International journal of cardiology 1995;47(3):225-33.
1994: K Naruse; K Shimizu; M Muramatsu; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(5):746-52.
1994: H Asano; K Shimizu; M Muramatsu; Y Iwama; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Prostaglandin H2 as an endothelium-derived contracting factor modulates endothelin-1-induced contraction.
Journal of hypertension 1994;12(4):383-90.
1993: K Shimizu; M Muramatsu; Y Kakegawa; H Asano; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Role of prostaglandin H2 as an endothelium-derived contracting factor in diabetic state.
Diabetes 1993;42(9):1246-52.
1993: H Asano; T Sone; H Tsuboi; H Sassa; Kazuhito Takeshima; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Diagnosis of right ventricular infarction by overlap images of simultaneous dual emission computed tomography using technetium-99m pyrophosphate and thallium-201.
The American journal of cardiology 1993;71(11):902-8.
1992: M Muramatsu; Y Iwama; K Shimizu; H Asano; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Hypoxia-elicited contraction of aorta and coronary artery via removal of endothelium-derived nitric oxide.
The American journal of physiology 1992;263(5 Pt 2):H1339-47.
1992: Kenji Okumura; J Kondo; K Shimizu; M Yoshino; Yukio Toki; H Hashimoto; T Ito
Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment.
Cardiovascular research 1992;26(6):626-30.
1992: Kenji Okumura; J Kondo; M Yoshino; K Ishikawa; H Asano; H Hashimoto; T Ito
Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension.
Molecular and cellular biochemistry 1992;112(1):15-21.
1992: Y Iwama; T Kato; M Muramatsu; H Asano; K Shimizu; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
Correlation with blood pressure of the acetylcholine-induced endothelium-derived contracting factor in the rat aorta.
Hypertension 1992;19(4):326-32.
1992: Y Iwama; M Muramatsu; Yukio Toki; Y Miyazaki; Kenji Okumura; H Hashimoto; T Ito
The mechanism of vasoconstriction induced by oxygen-derived free radicals in rat aorta.
Japanese journal of pharmacology 1992;58 Suppl 2():309P.
1991: Kenji Okumura; T Nishiura; K Shimizu; Y Iwama; J Kondo; H Hashimoto; T Ito
Fatty acid composition in 1,2-diacylglycerol of diabetic and insulin-treated diabetic rat hearts.
Japanese heart journal 1991;32(5):667-73.
1991: T Ito; T Kato; Y Iwama; M Muramatsu; K Shimizu; H Asano; Kenji Okumura; H Hashimoto; T Satake
Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide.
Journal of hypertension 1991;9(8):729-36.
1991: Kenji Okumura; T Nishiura; Y Awaji; J Kondo; H Hashimoto; T Ito
1,2-diacylglycerol content and its fatty acid composition in thoracic aorta of diabetic rats.
Diabetes 1991;40(7):820-4.
1991: K Kawaguchi; T Sone; H Tsuboi; H Sassa; Kenji Okumura; H Hashimoto; T Ito; T Satake
Quantitative estimation of infarct size by simultaneous dual radionuclide single photon emission computed tomography: comparison with peak serum creatine kinase activity.
American heart journal 1991;121(5):1353-60.
1991: Kenji Okumura; Y Yamada; J Kondo; H Hashimoto; T Ito; Junzoh Kitoh
Decreased 1,2-diacylglycerol levels in myopathic hamster hearts during the development of heart failure.
Journal of molecular and cellular cardiology 1991;23(4):409-16.
1991: Y Yamada; Kenji Okumura; H Hashimoto; T Ito; T Satake
Altered myocardial acetylcholine and norepinephrine concentrations in right ventricular hypertrophy and failure.
Heart and vessels 1991;6(3):150-7.
1990: T Kawai; Kenji Okumura; H Hashimoto; T Ito; T Satake
Alteration of 1,2-diacylglycerol content in ischemic and reperfused heart.
Molecular and cellular biochemistry 1990;99(1):1-8.
1990: T Ito; T Kato; Y Iwama; M Muramatsu; Kenji Okumura; H Hashimoto; T Satake; K Ogawa
[The role of endothelium-derived contracting factor (EDCF) and endothelium-derived relaxing factor (EDRF) in the aorta of the rat: identification of EDCF].
Kokyu to junkan. Respiration & circulation 1990;38(10):1001-7.
1990: J Kondo; Y Yamada; Kenji Okumura; H Hashimoto; T Ito; T Satake
1,2-diacylglycerol content in myocardium from spontaneously hypertensive rats during the development of hypertension.
Basic research in cardiology 1990;85(5):453-60.
1990: Y Awaji; H Hashimoto; Y Matsui; K Kawaguchi; Kenji Okumura; T Ito; T Satake
Isoenzyme profiles of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase in the diabetic heart: comparison with hereditary and catecholamine cardiomyopathies.
Cardiovascular research 1990;24(7):547-54.
1990: Kenji Okumura; J Kondo; Y Shirai; M Muramatsu; Y Yamada; H Hashimoto; T Ito
1,2-diacylglycerol content in thoracic aorta of spontaneously hypertensive rats.
Hypertension 1990;16(1):43-8.
1990: T Kato; Y Iwama; Kenji Okumura; H Hashimoto; T Ito; T Satake
Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat.
Hypertension 1990;15(5):475-81.
1990: Kenji Okumura; Y Shirai; J Kondo; H Hashimoto; T Ito; K Ogawa
Norepinephrine-induced 1,2-diacylglycerol accumulation and change in its fatty acid composition in the isolated perfused rat heart.
Molecular and cellular biochemistry 1990;93(2):173-8.
1990: Kenji Okumura; Y Yamada; J Kondo; H Hashimoto; T Ito; K Ogawa
Alteration in 1,2-diacylglycerol level and its fatty acid composition in hearts during the growth of hamsters.
Basic research in cardiology 1990;85(2):164-71.
1989: Kenji Okumura; Y Yamada; J Kondo; N Kobayashi; H Hashimoto; T Ito
Quantitative determination of 1,2-diacylglycerol in thoracic aorta of the rat using Iatroscan TLC/FID: effect of norepinephrine.
Lipids 1989;24(11):982-4.
1989: T Ito; Yukio Toki; N Hieda; Kenji Okumura; H Hashimoto; K Ogawa; T Satake
Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.
Japanese circulation journal 1989;53(9):1115-21.
1989: N Kobayashi; Kenji Okumura; H Hashimoto; T Ito; T Satake
Increased Ca2+ influx into platelets induced by thromboxane A2 analog in patients with ischemic heart disease.
Clinical cardiology 1989;12(8):456-60.
1989: Y Watanabe; Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
Effects of digoxin on acetylcholine and norepinephrine concentrations in rat myocardium.
Journal of cardiovascular pharmacology 1989;13(5):702-8.
1989: H Hashimoto; H Tsukamoto; Y Matsui; Y Awaji; Kenji Okumura; T Ito; K Ogawa
Latency from the onset of myocardial ischemia to the rise of serum creatine kinase activity is correlated inversely with infarct size in dogs.
Japanese heart journal 1989;30(2):197-203.
1989: Y Matsui; H Hashimoto; H Tsukamoto; Kenji Okumura; T Ito; K Ogawa; T Satake
Disappearance and appearance of isoenzymes of creatine kinase, lactate dehydrogenase and aspartate aminotransferase in the myocardium undergoing infarction.
Cardiovascular research 1989;23(3):249-53.
1989: N Akiyama; Kenji Okumura; Y Watanabe; H Hashimoto; T Ito; K Ogawa; T Satake
Altered acetylcholine and norepinephrine concentrations in diabetic rat hearts. Role of parasympathetic nervous system in diabetic cardiomyopathy.
Diabetes 1989;38(2):231-6.
1989: O Ohno; H Tsuboi; K Ogawa; Kenji Okumura; T Ito; H Hashimoto; T Satake
Effect of reperfusion on the cardiac acetylcholine and norepinephrine contents in rat hearts.
Journal of molecular and cellular cardiology 1989;21(2):139-49.
1988: Kenji Okumura; N Akiyama; H Hashimoto; K Ogawa; T Satake
Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats.
Diabetes 1988;37(9):1168-72.
1988: Kenji Okumura; T Kawai; H Hashimoto; T Ito; K Ogawa; T Satake
Sustained diacylglycerol formation in norepinephrine-stimulated rat heart is associated with alpha 1-adrenergic receptor.
Journal of cardiovascular pharmacology 1988;11(6):651-6.
1988: H Tsukamoto; H Hashimoto; Y Matsui; Kenji Okumura; T Ito; K Ogawa; T Satake
Detection of myocardial reperfusion by analysis of serum creatine kinase isoforms.
Clinical cardiology 1988;11(5):287-91.
1988: Kenji Okumura; K Ogawa; K Mizutani; T Kato
Sodium and potassium concentrations in erythrocytes of patients with congestive heart failure.
Japanese heart journal 1988;29(2):135-42.
1988: Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
Quantitation of 1,2-diacylglycerol in rat heart by iatroscan TLC/FID.
Lipids 1988;23(3):253-5.
1988: Yukio Toki; N Hieda; Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
Myocardial salvage by a novel thromboxane A2 synthetase inhibitor in a canine coronary occlusion-reperfusion model.
Arzneimittel-Forschung 1988;38(2):224-7.
1988: T Torii; Yukio Toki; N Hieda; Y Ito; Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
Effects of a new thromboxane A2-antagonist (ONO-3708) and a new leukotriene-antagonist (ONO-1078) on thromboxane A2 analogue-, leukotriene C4-, and D4-induced regional myocardial blood flow reduction.
Heart and vessels 1988;4(2):104-11.
1988: Kenji Okumura; Y Yamada; J Kondo; A Ishida; H Hashimoto; T Ito; K Ogawa; Junzoh Kitoh
Increased 1,2-diacylglycerol content in myopathic hamster hearts at a prenecrotic stage.
Life sciences 1988;43(17):1371-7.
1988: H Nakagawa; Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
Effects of atrial natriuretic polypeptide and organic nitrates on levels of relaxation and cyclic nucleotide of canine coronary artery with and without endothelial injury.
Heart and vessels 1988;4(1):19-25.
1988: A Ishida; T Tanahashi; Kenji Okumura; H Hashimoto; T Ito; K Ogawa; T Satake
A calmodulin antagonist (W-7) and a protein kinase C inhibitor (H-7) have no effect on atrial natriuretic peptide release induced by atrial stretch.
Life sciences 1988;42(17):1659-67.