FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Katsuhiko Okumura

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Procedures

Reverse Transcriptase Polymerase Chain Reaction

Disorders

Colorectal Neoplasms

Co-author Network

Publications

TOP 3
Daisuke Yamasaki; Tsutomu Nakamura; Noboru Okamura; Makiko Kokudai; Naoki Inui; Kazuhiko Takeuchi; Hiroshi Watanabe; Midori Hirai; Katsuhiko Okumura; Toshiyuki Sakaeda
Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.
Naoko Chayahara; Takao Tamura; Motohiro Yamamori; Yuko Kadowaki; Tatsuya Okuno; Ikuya Miki; Masahiro Tsuda; Hogara Nishisaki; Tetsuo Maeda; Yoshifumi Inoue; Katsuhiko Okumura; Takeshi Azuma; Masato Kasuga; Toshiyuki Sakaeda; Midori Hirai
Phase I and pharmacokinetic study of tegafur-uracil/leucovorin combined with 5-fluorouracil/leucovorin and irinotecan in patients with advanced colorectal cancer.
Tsutomu Nakamura; Noboru Okamura; M Yagi; H Omatsu; Motohiro Yamamori; A Kuwahara; Kohshi Nishiguchi; Masanori Horinouchi; Katsuhiko Okumura; Toshiyuki Sakaeda
Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Katsuhiko Okumura (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2009: Daisuke Yamasaki; Tsutomu Nakamura; Noboru Okamura; Makiko Kokudai; Naoki Inui; Kazuhiko Takeuchi; Hiroshi Watanabe; Midori Hirai; Katsuhiko Okumura; Toshiyuki Sakaeda
Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(2):126-32.
2009: Naoko Chayahara; Takao Tamura; Motohiro Yamamori; Yuko Kadowaki; Tatsuya Okuno; Ikuya Miki; Masahiro Tsuda; Hogara Nishisaki; Tetsuo Maeda; Yoshifumi Inoue; Katsuhiko Okumura; Takeshi Azuma; Masato Kasuga; Toshiyuki Sakaeda; Midori Hirai
Phase I and pharmacokinetic study of tegafur-uracil/leucovorin combined with 5-fluorouracil/leucovorin and irinotecan in patients with advanced colorectal cancer.
American journal of clinical oncology 2009;32(1):56-60.
2009: Tsutomu Nakamura; Noboru Okamura; M Yagi; H Omatsu; Motohiro Yamamori; A Kuwahara; Kohshi Nishiguchi; Masanori Horinouchi; Katsuhiko Okumura; Toshiyuki Sakaeda
Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles.
Genetics and molecular research : GMR 2009;8(2):397-403.
2008: Noboru Okamura; Taro Masuda; Akinobu Gotoh; Toshiro Shirakawa; Shuji Terao; Naoki Kaneko; Kazuki Suganuma; Makoto Watanabe; Toshiya Matsubara; Ryota Seto; Jun Matsumoto; Megumi Kawakami; Motohiro Yamamori; Tsutomu Nakamura; Tatsurou Yagami; Toshiyuki Sakaeda; Masato Fujisawa; Osamu Nishimura; Katsuhiko Okumura
Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma.
Proteomics 2008;8(15):3194-203.
2008: Motohiro Yamamori; Mayuko Taniguchi; Shingo Maeda; Tsutomu Nakamura; Noboru Okamura; Akiko Kuwahara; Koichi Iwaki; Takao Tamura; Nobuo Aoyama; Svetlana Markova; Masato Kasuga; Katsuhiko Okumura; Toshiyuki Sakaeda
VEGF T-1498C polymorphism, a predictive marker of differentiation of colorectal adenocarcinomas in Japanese.
International journal of medical sciences 2008;5(2):80-6.
2007: Tsutomu Nakamura; Kandai Nozu; Kazumoto Iijima; Norishige Yoshikawa; Yuka Moriya; Motohiro Yamamori; Asae Kako; Masafumi Matsuo; Aki Sakurai; Noboru Okamura; Toshihisa Ishikawa; Katsuhiko Okumura; Toshiyuki Sakaeda
Association of cumulative cyclosporine dose with its irreversible nephrotoxicity in Japanese patients with pediatric-onset autoimmune diseases.
Biological & pharmaceutical bulletin 2007;30(12):2371-5.
2007: Svetlana Markova; Tsutomu Nakamura; Hiroo Makimoto; Tomoki Ichijima; Motohiro Yamamori; Akiko Kuwahara; Koichi Iwaki; Kohshi Nishiguchi; Noboru Okamura; Katsuhiko Okumura; Toshiyuki Sakaeda
IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation.
Biological & pharmaceutical bulletin 2007;30(8):1481-7.
2007: Tatsuya Okuno; Takao Tamura; Motohiro Yamamori; Naoko Chayahara; Toshio Yamada; Ikuya Miki; Noboru Okamura; Yuko Kadowaki; Daisuke Shirasaka; Nobuo Aoyama; Tsutomu Nakamura; Katsuhiko Okumura; Takeshi Azuma; Masato Kasuga; Toshiyuki Sakaeda
Favorable genetic polymorphisms predictive of clinical outcome of chemoradiotherapy for stage II/III esophageal squamous cell carcinoma in Japanese.
American journal of clinical oncology 2007;30(3):252-7.
2007: Megumi Kawakami; Tsutomu Nakamura; Noboru Okamura; Chiho Komoto; Svetlana Markova; Hironao Kobayashi; Naofumi Hashimoto; Katsuhiko Okumura; Toshiyuki Sakaeda
Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells.
Biological & pharmaceutical bulletin 2007;30(6):1065-73.
2007: Chiho Komoto; Tsutomu Nakamura; Motohiro Yamamori; Nobuko Ohmoto; Hironao Kobayashi; Akiko Kuwahara; Kohshi Nishiguchi; Kohji Takara; Yusuke Tanigawara; Noboru Okamura; Katsuhiko Okumura; Toshiyuki Sakaeda
Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA.
The Kobe journal of medical sciences 2007;53(6):355-63.
2007: Chiho Komoto; Tsutomu Nakamura; Nobuko Ohmoto; Hironao Kobayashi; Tatsurou Yagami; Kohshi Nishiguchi; Koichi Iwaki; Akiko Kuwahara; Motohiro Yamamori; Noboru Okamura; Katsuhiko Okumura; Toshiyuki Sakaeda
Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs.
The Kobe journal of medical sciences 2007;53(6):335-43.
2007: Hiroyuki Imanishi; Noboru Okamura; Mariko Yagi; Yukari Noro; Yuka Moriya; Tsutomu Nakamura; Akira Hayakawa; Yasuhiro Takeshima; Toshiyuki Sakaeda; Masafumi Matsuo; Katsuhiko Okumura
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.
Journal of human genetics 2007;52(2):166-71.
2006: Koichi Iwaki; Toshiyuki Sakaeda; Mikio Kakumoto; Tsutomu Nakamura; Chiho Komoto; Noboru Okamura; Kohshi Nishiguchi; Takashi Shiraki; Masanori Horinouchi; Katsuhiko Okumura
Haloperidol is an inhibitor but not substrate for MDR1/P-glycoprotein.
The Journal of pharmacy and pharmacology 2006;58(12):1617-22.
2006: Jiang-shu Jin; Toshiyuki Sakaeda; Mikio Kakumoto; Kohshi Nishiguchi; Tsutomu Nakamura; Noboru Okamura; Katsuhiko Okumura
Effect of therapeutic moderate hypothermia on multi-drug resistance protein 1-mediated transepithelial transport of drugs.
Neurologia medico-chirurgica 2006;46(7):321-7; discussion 327.
2006: Tatsuya Koyama; Tsutomu Nakamura; Chiho Komoto; Toshiyuki Sakaeda; Mayuko Taniguchi; Noboru Okamura; Takao Tamura; Nobuo Aoyama; Takashi Kamigaki; Yoshikazu Kuroda; Masato Kasuga; Keiichi Kadoyama; Katsuhiko Okumura
MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese.
Biological & pharmaceutical bulletin 2006;29(7):1449-53.
2006: Svetlana Markova; Tsutomu Nakamura; Toshiyuki Sakaeda; Hiroo Makimoto; Hitoshi Uchiyama; Noboru Okamura; Katsuhiko Okumura
Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation.
Drug metabolism and pharmacokinetics 2006;21(3):194-200.
2006: Yasuhiro Takeshima; Mariko Yagi; Hiroko Wada; Kazuto Ishibashi; Atsushi Nishiyama; Mikio Kakumoto; Toshiyuki Sakaeda; Ryuichi Saura; Katsuhiko Okumura; Masafumi Matsuo
Intravenous infusion of an antisense oligonucleotide results in exon skipping in muscle dystrophin mRNA of Duchenne muscular dystrophy.
Pediatric research 2006;59(5):690-4.
2006: Chiho Komoto; Tsutomu Nakamura; Toshiyuki Sakaeda; Deanna L Kroetz; Toshio Yamada; Hideaki Omatsu; Tatsuya Koyama; Noboru Okamura; Ikuya Miki; Takao Tamura; Nobuo Aoyama; Masato Kasuga; Katsuhiko Okumura
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.
Drug metabolism and pharmacokinetics 2006;21(2):126-32.
2006: Yuka Moriya; Tsutomu Nakamura; Noboru Okamura; Toshiyuki Sakaeda; Masanori Horinouchi; Takao Tamura; Nobuo Aoyama; Masato Kasuga; Katsuhiko Okumura
Comparison of synthetic DNA templates with authentic cDNA templates in terms of quantification by real-time quantitative reverse transcription polymerase chain reaction.
Biological & pharmaceutical bulletin 2006;29(3):535-8.
2006: Toshiyuki Sakaeda; Hideki Fujino; Chiho Komoto; Mikio Kakumoto; Jiang-shu Jin; Koichi Iwaki; Kohshi Nishiguchi; Tsutomu Nakamura; Noboru Okamura; Katsuhiko Okumura
Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.
Pharmaceutical research 2006;23(3):506-12.
2006: Tatsuya Osuga; Toshiyuki Sakaeda; Tsutomu Nakamura; Toshio Yamada; Tatsuya Koyama; Takao Tamura; Nobuo Aoyama; Noboru Okamura; Masato Kasuga; Katsuhiko Okumura
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
Biological & pharmaceutical bulletin 2006;29(2):324-9.
2006: Toshiyuki Sakaeda; Kazumoto Iijima; Kandai Nozu; Tsutomu Nakamura; Yuka Moriya; Mika Nishikawa; Atsushi Wada; Noboru Okamura; Masafumi Matsuo; Katsuhiko Okumura
Prediction of systemic exposure to cyclosporine in Japanese pediatric patients.
Journal of human genetics 2006;51(11):969-76.
2006: Tsutomu Nakamura; Takeshi Ioroi; Toshiyuki Sakaeda; Masanori Horinouchi; Nobuhide Hayashi; Kensuke Saito; Mitsuro Kosaka; Noboru Okamura; Keiichi Kadoyama; Shunichi Kumagai; Katsuhiko Okumura
Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients.
International journal of medical sciences 2006;3(3):92-6.
2006: Kohji Takara; Toshiyuki Sakaeda; Katsuhiko Okumura
An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy.
Current pharmaceutical design 2006;12(3):273-86.
2005: Toshiyuki Sakaeda; Noboru Okamura; Akinobu Gotoh; Toshiro Shirakawa; Shuji Terao; Masahi Morioka; Kenji Tokui; Hisato Tanaka; Tsutomu Nakamura; Mariko Yagi; Yoshihiro Nishimura; Mitsuhiro Yokoyama; Katsuhiko Okumura
EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients.
Pharmaceutical research 2005;22(10):1757-61.
2005: Kandai Nozu; Kazumoto Iijima; Toshiyuki Sakaeda; Katsuhiko Okumura; Koichi Nakanishi; Norishige Yoshikawa; Masataka Honda; Masahiro Ikeda; Masafumi Matsuo
Cyclosporin A absorption profiles in children with nephrotic syndrome.
Pediatric nephrology (Berlin, Germany) 2005;20(7):910-3.
2005: Tsutomu Nakamura; Toshiyuki Sakaeda; Masayoshi Takahashi; Koji Hashimoto; Nobuhiro Gemma; Yuka Moriya; Chiho Komoto; Kohshi Nishiguchi; Noboru Okamura; Katsuhiko Okumura
Simultaneous determination of single nucleotide polymorphisms of MDR1 genes by electrochemical DNA chip.
Drug metabolism and pharmacokinetics 2005;20(3):219-25.
2005: Toshiyuki Sakaeda; Koichi Iwaki; Mikio Kakumoto; Mika Nishikawa; Toshiro Niwa; Jiang-shu Jin; Tsutomu Nakamura; Kohshi Nishiguchi; Noboru Okamura; Katsuhiko Okumura
Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs.
The Journal of pharmacy and pharmacology 2005;57(6):759-64.
2005: Ikuya Miki; Takao Tamura; Tsutomu Nakamura; Hiroo Makimoto; Noriko Hamana; Hitoshi Uchiyama; Daisuke Shirasaka; Yoshinori Morita; Hiroyuki Yamada; Nobuo Aoyama; Toshiyuki Sakaeda; Katsuhiko Okumura; Masato Kasuga
Circadian variability of pharmacokinetics of 5-fluorouracil and CLOCK T3111C genetic polymorphism in patients with esophageal carcinoma.
Therapeutic drug monitoring 2005;27(3):369-74.
2004: Motohiro Yamamori; Toshiyuki Sakaeda; Tsutomu Nakamura; Noboru Okamura; Takao Tamura; Nobuo Aoyama; Takashi Kamigaki; Masakazu Ohno; Toshiro Shirakawa; Akinobu Gotoh; Yoshikazu Kuroda; Masafumi Matsuo; Masato Kasuga; Katsuhiko Okumura
Association of VEGF genotype with mRNA level in colorectal adenocarcinomas.
Biochemical and biophysical research communications 2004;325(1):144-50.
2004: Akinobu Gotoh; Toshiyuki Sakaeda; Takashi Kimura; Toshiro Shirakawa; Yoshitaka Wada; Atsushi Wada; Tetsutaro Kimachi; Yoshiji Takemoto; Akira Iida; Seigo Iwakawa; Midori Hirai; Hisako Tomita; Noboru Okamura; Tsutomu Nakamura; Katsuhiko Okumura
Antiproliferative activity of Rhinacanthus nasutus (L.) Kurz extracts and the active moiety, Rhinacanthin C.
Biological & pharmaceutical bulletin 2004;27(7):1070-4.
2004: Kohji Takara; Toshiyuki Sakaeda; Katsuhiko Okumura
Carvedilol: a new candidate for reversal of MDR1/P-glycoprotein-mediated multidrug resistance.
Anti-cancer drugs 2004;15(4):303-9.
2004: Takako Nakahara; Toshiyuki Sakaeda; Tsutomu Nakamura; Takao Tamura; Chiharu Nishioka; Nobuo Aoyama; Noboru Okamura; Toshiro Shirakawa; Akinobu Gotoh; Takashi Kamigaki; Masakazu Ohno; Yoshikazu Kuroda; Masafumi Matsuo; Masato Kasuga; Katsuhiko Okumura
Chemosensitivity assessed by collagen gel droplet embedded culture drug sensitivity test, and MDR1, MRP1, and MRP2 mRNA expression in human colorectal adenocarcinomas.
Pharmaceutical research 2004;21(3):406-12.
2004: Shunichi Kumagai; Fusao Komada; Tomoko Kita; Akio Morinobu; Shoichi Ozaki; Hiroshi Ishida; Hajime Sano; Tsukasa Matsubara; Katsuhiko Okumura
N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis.
Pharmaceutical research 2004;21(2):324-9.
2004: Chiharu Nishioka; Toshiyuki Sakaeda; Tsutomu Nakamura; Yuka Moriya; Noboru Okamura; Takao Tamura; Takako Nakahara; Nobuo Aoyama; Takashi Kamigaki; Masakazu Ohno; Yoshikazu Kuroda; Masato Kasuga; Katsuhiko Okumura
MDR1, MRP1 and MRP2 genotypes and in vitro chemosensitivity in Japanese patients with colorectal adenocarcinomas.
The Kobe journal of medical sciences 2004;50(5-6):181-8.
2004: Toshiyuki Sakaeda; Tsutomu Nakamura; Katsuhiko Okumura
Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.
Current topics in medicinal chemistry 2004;4(13):1385-98.
2003: Teruhisa Matsubayashi; Toshiyuki Sakaeda; Tomoko Kita; Yoshie Kurimoto; Tsutomu Nakamura; Kohshi Nishiguchi; Takuya Fujita; Fumio Kamiyama; Akira Yamamoto; Katsuhiko Okumura
Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration.
Biological & pharmaceutical bulletin 2003;26(9):1365-7.
2003: Toshiyuki Sakaeda; Tsutomu Nakamura; Katsuhiko Okumura
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs.
Pharmacogenomics 2003;4(4):397-410.
2003: Yoshinori Morita; Toshiyuki Sakaeda; Masanori Horinouchi; Tsutomu Nakamura; Kohei Kuroda; Ikuya Miki; Ken Yoshimura; Toshiyuki Sakai; Daisuke Shirasaka; Takao Tamura; Nobuo Aoyama; Masato Kasuga; Katsuhiko Okumura
MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects.
Pharmaceutical research 2003;20(4):552-6.
2003: Tomoko Kita; Toshiyuki Sakaeda; Takahiko Baba; Nobuo Aoyama; Mikio Kakumoto; Yoshie Kurimoto; Yuko Kawahara; Noboru Okamura; Shirou Kirita; Masato Kasuga; Katsuhiko Okumura
Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors.
Biological & pharmaceutical bulletin 2003;26(3):386-90.
2003: Yu-Wen Liu; Toshiyuki Sakaeda; Kohji Takara; Tsutomu Nakamura; Nobuko Ohmoto; Chiho Komoto; Hironao Kobayashi; Tatsurou Yagami; Noboru Okamura; Katsuhiko Okumura
Effects of reactive oxygen species on cell proliferation and death in HeLa cells and its MDR1-overexpressing derivative cell line.
Biological & pharmaceutical bulletin 2003;26(2):278-81.
2003: Mikio Kakumoto; Toshiyuki Sakaeda; Kohji Takara; Tsutomu Nakamura; Tomoko Kita; Tatsurou Yagami; Hironao Kobayashi; Noboru Okamura; Katsuhiko Okumura
Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil.
Cancer science 2003;94(1):81-6.
2003: Ikuya Miki; Nobuo Aoyama; Toshiyuki Sakai; Daisuke Shirasaka; Casmir Wambura; Shuji Maekawa; Kohei Kuroda; Takao Tamura; Tomoko Kita; Toshiyuki Sakaeda; Katsuhiko Okumura; Masato Kasuga
Impact of clarithromycin resistance and CYP2C19 genetic polymorphism on treatment efficacy of Helicobacter pylori infection with lansoprazole- or rabeprazole-based triple therapy in Japan.
European journal of gastroenterology & hepatology 2003;15(1):27-33.
2003: Teruhisa Matsubayashi; Toshiyuki Sakaeda; Tomoko Kita; Tsutomu Nakamura; Mikio Kakumoto; Yoko Funasaka; Masamitsu Ichihashi; Takuya Fujita; Fumio Kamiyama; Akira Yamamoto; James J Nordlund; Masafumi Kaneko; Akira Iida; Katsuhiko Okumura
Effects of various storage conditions and alterations of antioxidant contents on chromatic aberration of hydroquinone ointment.
Biological & pharmaceutical bulletin 2003;26(1):120-2.
2002: Mikio Kakumoto; Kohji Takara; Toshiyuki Sakaeda; Yusuke Tanigawara; Tomoko Kita; Katsuhiko Okumura
MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.
Biological & pharmaceutical bulletin 2002;25(12):1604-7.
2002: Toshiyuki Sakaeda; Tsutomu Nakamura; Katsuhiko Okumura
MDR1 genotype-related pharmacokinetics and pharmacodynamics.
Biological & pharmaceutical bulletin 2002;25(11):1391-400.
2002: Masanori Horinouchi; Toshiyuki Sakaeda; Tsutomu Nakamura; Yoshinori Morita; Takao Tamura; Nobuo Aoyama; Masato Kasuga; Katsuhiko Okumura
Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.
Pharmaceutical research 2002;19(10):1581-5.
2002: Toshiyuki Sakaeda; Tsutomu Nakamura; Midori Hirai; Takashi Kimura; Atsushi Wada; Tatsurou Yagami; Hironao Kobayashi; Shunji Nagata; Noboru Okamura; Takayoshi Yoshikawa; Toshiro Shirakawa; Akinobu Gotoh; Masafumi Matsuo; Katsuhiko Okumura
MDR1 up-regulated by apoptotic stimuli suppresses apoptotic signaling.
Pharmaceutical research 2002;19(9):1323-9.
2002: Yusuke Tanigawara; Tomoko Kita; Nobuo Aoyama; Manabu Gobara; Fusao Komada; Toshiyuki Sakai; Masato Kasuga; Hisakatsu Hatanaka; Toshiyuki Sakaeda; Katsuhiko Okumura
N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events.
Biological & pharmaceutical bulletin 2002;25(8):1058-62.
2002: Kohji Takara; Toshiyuki Sakaeda; Yusuke Tanigawara; Kohshi Nishiguchi; Nobuko Ohmoto; Masanori Horinouchi; Fusao Komada; Noriaki Ohnishi; Teruyoshi Yokoyama; Katsuhiko Okumura
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;16(3):159-65.
2002: Tomoko Kita; Toshiyuki Sakaeda; Nobuo Aoyama; Toshiyuki Sakai; Yuko Kawahara; Masato Kasuga; Katsuhiko Okumura
Optimal dose of omeprazole for CYP2C19 extensive metabolizers in anti-Helicobacter pylori therapy: pharmacokinetic considerations.
Biological & pharmaceutical bulletin 2002;25(7):923-7.
2002: Kohji Takara; Toshiyuki Sakaeda; Tatsurou Yagami; Hironao Kobayashi; Nobuko Ohmoto; Masanori Horinouchi; Kohshi Nishiguchi; Katsuhiko Okumura
Cytotoxic effects of 27 anticancer drugs in HeLa and MDR1-overexpressing derivative cell lines.
Biological & pharmaceutical bulletin 2002;25(6):771-8.
2002: Tsutomu Nakamura; Toshiyuki Sakaeda; Masanori Horinouchi; Takao Tamura; Nobuo Aoyama; Toshiro Shirakawa; Masafumi Matsuo; Masato Kasuga; Katsuhiko Okumura
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.
Clinical pharmacology and therapeutics 2002;71(4):297-303.
2002: Toshiyuki Sakaeda; Kohji Takara; Mikio Kakumoto; Nobuko Ohmoto; Tsutomu Nakamura; Koichi Iwaki; Yusuke Tanigawara; Katsuhiko Okumura
Simvastatin and lovastatin, but not pravastatin, interact with MDR1.
The Journal of pharmacy and pharmacology 2002;54(3):419-23.
2002: Kohji Takara; Mikio Kakumoto; Yusuke Tanigawara; Junko Funakoshi; Toshiyuki Sakaeda; Katsuhiko Okumura
Interaction of digoxin with antihypertensive drugs via MDR1.
Life sciences 2002;70(13):1491-500.
2002: Atsushi Wada; Toshiyuki Sakaeda; Kohji Takara; Midori Hirai; Takashi Kimura; Nobuko Ohmoto; Jie Zhou; Tsutomu Nakamura; Hironao Kobayashi; Noboru Okamura; Tatsurou Yagami; Katsuhiko Okumura
Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.
Drug metabolism and pharmacokinetics 2002;17(5):467-74.
2002: Teruhisa Matsubayashi; Toshiyuki Sakaeda; Tomoko Kita; Michiyo Nara; Yoko Funasaka; Masamitsu Ichihashi; Takuya Fujita; Fumio Kamiyama; Akira Yamamoto; James J Nordlund; Masafumi Kaneko; Akira Iida; Midori Hirai; Katsuhiko Okumura
Pharmaceutical and clinical assessment of hydroquinone ointment prepared by extemporaneous nonsterile compounding.
Biological & pharmaceutical bulletin 2002;25(1):92-6.
2002: Nobuo Aoyama; Daisuke Shirasaka; Katsuhiko Okumura
[Progress of tailor-made treatment of peptic ulcer].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(1):174-81.
2002: Tsutomu Nakamura; Toshiyuki Sakaeda; Nobuko Ohmoto; Takao Tamura; Nobuo Aoyama; Toshiro Shirakawa; Takashi Kamigaki; Takeshi Nakamura; Ke Ih Kim; Soo Ryang Kim; Yoshikazu Kuroda; Masafumi Matsuo; Masato Kasuga; Katsuhiko Okumura
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):4-6.
2001: Hiroo Makimoto; Toshiyuki Sakaeda; Kohshi Nishiguchi; Tomoko Kita; Toshiyuki Sakai; Fusao Komada; Katsuhiko Okumura
Beta2-adrenergic receptor genotype-related changes in cAMP levels in peripheral blood mononuclear cells after multiple-dose oral procaterol.
Pharmaceutical research 2001;18(12):1651-4.
2001: Toshiyuki Sakaeda; Takeshi Nakamura; Masanori Horinouchi; Mikio Kakumoto; Nobuko Ohmoto; Toshiyuki Sakai; Yoshinori Morita; Takao Tamura; Nobuo Aoyama; Midori Hirai; Masato Kasuga; Katsuhiko Okumura
MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.
Pharmaceutical research 2001;18(10):1400-4.
2001: Tomoko Kita; Toshiyuki Sakaeda; S Adachi; Toshiyuki Sakai; Nobuo Aoyama; Hisakatsu Hatanaka; Masato Kasuga; Katsuhiko Okumura
N-Acetyltransferase 2 genotype correlates with sulfasalazine pharmacokinetics after multiple dosing in healthy Japanese subjects.
Biological & pharmaceutical bulletin 2001;24(10):1176-80.
2001: N Iida; Kohji Takara; Nobuko Ohmoto; Takeshi Nakamura; Takashi Kimura; Atsushi Wada; Midori Hirai; Toshiyuki Sakaeda; Katsuhiko Okumura
Reversal effects of antifungal drugs on multidrug resistance in MDR1-overexpressing HeLa cells.
Biological & pharmaceutical bulletin 2001;24(9):1032-6.
2001: Toshiyuki Sakaeda; Noboru Okamura; S Nagata; Tatsurou Yagami; Masanori Horinouchi; Katsuhiko Okumura; F Yamashita; M Hashida
Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans.
Biological & pharmaceutical bulletin 2001;24(8):935-40.
2001: Yusuke Tanigawara; Tomoko Kita; M Hirono; Toshiyuki Sakaeda; Fusao Komada; Katsuhiko Okumura
Identification of N-acetyltransferase 2 and CYP2C19 genotypes for hair, buccal cell swabs, or fingernails compared with blood.
Therapeutic drug monitoring 2001;23(4):341-6.
2001: Toshiyuki Sakai; Nobuo Aoyama; Tomoko Kita; Toshiyuki Sakaeda; Kohshi Nishiguchi; Y Nishitora; T Hohda; D Sirasaka; Takao Tamura; Yusuke Tanigawara; Masato Kasuga; Katsuhiko Okumura
CYP2C19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects.
Pharmaceutical research 2001;18(6):721-7.
2001: Takeshi Nakamura; Mikio Kakumoto; Toshiyuki Sakaeda; K Nagahiro; R Ohmichi; K Yamashita; Kohshi Nishiguchi; Midori Hirai; Katsuhiko Okumura
Effect of serum triglyceride concentration on the fluctuation of whole blood concentration of cyclosporin A in patients.
Biological & pharmaceutical bulletin 2001;24(6):683-7.
2001: Tomoko Kita; Yusuke Tanigawara; Nobuo Aoyama; T Hohda; Y Saijoh; Fusao Komada; Toshiyuki Sakaeda; Katsuhiko Okumura; Toshiyuki Sakai; Masato Kasuga
CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability.
Pharmaceutical research 2001;18(5):615-21.
2001: Tomoko Kita; Yusuke Tanigawara; S Chikazawa; Hisakatsu Hatanaka; Toshiyuki Sakaeda; Fusao Komada; Seigo Iwakawa; Katsuhiko Okumura
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
Biological & pharmaceutical bulletin 2001;24(5):544-9.
2001: Takeshi Nakamura; Mikio Kakumoto; K Yamashita; Kohji Takara; Yusuke Tanigawara; Toshiyuki Sakaeda; Katsuhiko Okumura
Factors influencing the prediction of steady state concentrations of digoxin.
Biological & pharmaceutical bulletin 2001;24(4):403-8.
2000: Kohji Takara; Yusuke Tanigawara; Fusao Komada; Kohshi Nishiguchi; Toshiyuki Sakaeda; Katsuhiko Okumura
The novel anticancer drug KRN5500 interacts with, but is hardly transported by, human P-glycoprotein.
Japanese journal of cancer research : Gann 2000;91(2):248-54.
1999: Kohji Takara; Yusuke Tanigawara; Fusao Komada; Kohshi Nishiguchi; Toshiyuki Sakaeda; Katsuhiko Okumura
Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs.
Biological & pharmaceutical bulletin 1999;22(12):1355-9.
1999: K Shirakawa; Kohji Takara; Yusuke Tanigawara; Nobuo Aoyama; M Kasuga; Fusao Komada; Toshiyuki Sakaeda; Katsuhiko Okumura
Interaction of docetaxel ("Taxotere") with human P-glycoprotein.
Japanese journal of cancer research : Gann 1999;90(12):1380-6.
1999: Yusuke Tanigawara; Nobuo Aoyama; Tomoko Kita; K Shirakawa; Fusao Komada; Masato Kasuga; Katsuhiko Okumura
CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori.
Clinical pharmacology and therapeutics 1999;66(5):528-34.
1999: Fusao Komada; Kohshi Nishiguchi; Yusuke Tanigawara; Seigo Iwakawa; Katsuhiko Okumura
Effects of secretable SOD delivered by genetically modified cells on xanthine/xanthine oxidase and paraquat-induced cytotoxicity in vitro.
Biological & pharmaceutical bulletin 1999;22(8):846-53.
1999: Nobuo Aoyama; Yusuke Tanigawara; Tomoko Kita; Toshiyuki Sakai; K Shirakawa; Daisuke Shirasaka; F Kodama; Katsuhiko Okumura; Masato Kasuga
Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers.
Journal of gastroenterology 1999;34 Suppl 11():80-3.
1998: Kohshi Nishiguchi; Fusao Komada; Yusuke Tanigawara; Y Sakai; Seigo Iwakawa; Katsuhiko Okumura
Effects of Cu, Zn-superoxide dismutase delivered by genetically modified skin fibroblasts on cold-induced skin edema in rats.
Biological & pharmaceutical bulletin 1998;21(12):1379-81.
1998: Nobuya Kusunoki; Kohji Takara; Yusuke Tanigawara; A Yamauchi; K Ueda; Fusao Komada; Yonson Ku; Yoshikazu Kuroda; Y Saitoh; Katsuhiko Okumura
Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.
Japanese journal of cancer research : Gann 1998;89(11):1220-8.
1997: M Okazaki; Yusuke Tanigawara; Tomoko Kita; Fusao Komada; Katsuhiko Okumura
Cross-reactivity of TDX and OPUS immunoassay systems for serum digoxin determination.
Therapeutic drug monitoring 1997;19(6):657-62.
1997: Katsuhiko Okumura; Kohshi Nishiguchi; Yusuke Tanigawara; S Mori; Seigo Iwakawa; Fusao Komada
Enhanced anti-inflammatory effects of Cu, Zn-superoxide dismutase delivered by genetically modified skin fibroblasts in vitro and in vivo.
Pharmaceutical research 1997;14(9):1223-7.
1997: Fusao Komada; Kohshi Nishiguchi; Yusuke Tanigawara; M Ishida; X Y Wu; Seigo Iwakawa; R Sasada; Katsuhiko Okumura
Protective effect of transfection with secretable superoxide dismutase (SOD) (a signal sequence-SOD fusion protein coding cDNA) expression vector on superoxide anion-induced cytotoxicity in vitro.
Biological & pharmaceutical bulletin 1997;20(5):530-6.
1997: Katsuhiko Okumura; Tomoko Kita; S Chikazawa; Fusao Komada; Seigo Iwakawa; Yusuke Tanigawara
Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism.
Clinical pharmacology and therapeutics 1997;61(5):509-17.