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Eric Oldfield

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Chemicals & Drugs

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Wei Zhu; Joshua Olson; Anna Sankovsky; William Sinko; Ke Wang; Yang Wang; Yonghui Zhang; Rong Cao; César Augusto F de Oliveira; Mary E Hensler; Kai Li; Steffen Lindert; Yi-Liang Liu; J Andrew McCammon; Douglas A Mitchell; Katie J Molohon; Victor Nizet; Eric Oldfield
Antibacterial drug leads targeting isoprenoid biosynthesis.
Weixue Wang; Ingrid Span; Ke Wang; Adelbert Bacher; Michael Groll; Johann Jauch; Eric Oldfield
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.
Yi-Liang Liu; Satish K Nair; Francisco Guerra; Kevin Houlihan; Cancan Huang; Jikun Li; Zhi Li; Ke Wang; Weixue Wang; Yong Zhang; Wei Zhu; Eric Oldfield
Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.

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All Publications

2013: Wei Zhu; Joshua Olson; Anna Sankovsky; William Sinko; Ke Wang; Yang Wang; Yonghui Zhang; Rong Cao; César Augusto F de Oliveira; Mary E Hensler; Kai Li; Steffen Lindert; Yi-Liang Liu; J Andrew McCammon; Douglas A Mitchell; Katie J Molohon; Victor Nizet; Eric Oldfield
Antibacterial drug leads targeting isoprenoid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):123-8.
2012: Weixue Wang; Ingrid Span; Ke Wang; Adelbert Bacher; Michael Groll; Johann Jauch; Eric Oldfield
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.
Journal of the American Chemical Society 2012;134(27):11225-34.
2012: Yi-Liang Liu; Satish K Nair; Francisco Guerra; Kevin Houlihan; Cancan Huang; Jikun Li; Zhi Li; Ke Wang; Weixue Wang; Yong Zhang; Wei Zhu; Eric Oldfield
Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8558-63.
2012: Fu-Yang Lin; Yi-Liang Liu; Jordan Axelson; Rong Cao; Kai Li; Ran Pang; Wei Zhu; Eric Oldfield
Head-to-head prenyl tranferases: anti-infective drug targets.
Journal of medicinal chemistry 2012;55(9):4367-72.
2012: Fu-Yang Lin; Yi-Liang Liu; Victor Nizet; Ran Pang; Wdee Thienphrapa; Ke Wang; Yonghui Zhang; Wei Zhu; Ohn A Chow; Mary Hensler; Eric Oldfield
Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
ChemMedChem 2012;7(4):561-4.
2012: Joo Hwan No; Fernando de Macedo Dossin; Xinxin Feng; Lucio H Freitas-Junior; Raymond Hui; Eunhae Lee; Yi-Liang Liu; Ke Wang; Jinyoung Anny Yoo; Yonghui Zhang; Wei Zhu; Eric Oldfield
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(11):4058-63.
2012: Eric Oldfield; Fu-Yang Lin
Terpene biosynthesis: modularity rules.
Angewandte Chemie (International ed. in English) 2012;51(5):1124-37.
2011: Hong Wang; Rong Cao; Ju Feng; José-Luis Giner; Jukka Mönkkönen; Eric Oldfield; Kia-Joo Puan; Ghanashyam Sarikonda; Yoshimasa Tanaka; Craig Morita
Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5099-113.
2011: Benjamin J Wylie; Lindsay J Sperling; W Trent Franks; Andrew J Nieuwkoop; Eric Oldfield; Chad M Rienstra
Ultrahigh resolution protein structures using NMR chemical shift tensors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):16974-9.
2011: Weixue Wang; Ke Wang; Jikun Li; Saritha Nellutla; Tatyana I Smirnova; Eric Oldfield
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.
Journal of the American Chemical Society 2011;133(22):8400-3.
2011: Weixue Wang; Jikun Li; Ke Wang; Tatyana I Smirnova; Eric Oldfield
Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation.
Journal of the American Chemical Society 2011;133(17):6525-8.
2010: Fu-Yang Lin; Chia-I Liu; Yi-Liang Liu; Yonghui Zhang; Ke Wang; Wen-Yih Jeng; Tzu-Ping Ko; Rong Cao; Andrew H-J Wang; Eric Oldfield
Mechanism of action and inhibition of dehydrosqualene synthase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21337-42.
2010: Eric Oldfield
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
Accounts of chemical research 2010;43(9):1216-26.
2010: Rong Cao; Yonghui Zhang; Francis M Mann; Cancan Huang; Dushyant Mukkamala; Michael P Hudock; Matthew E Mead; Sladjana Prisic; Ke Wang; Fu-Yang Lin; Ting-Kai Chang; Reuben J Peters; Eric Oldfield
Diterpene cyclases and the nature of the isoprene fold.
Proteins 2010;78(11):2417-32.
2010: Weixue Wang; Jikun Li; Ke Wang; Cancan Huang; Yong Zhang; Eric Oldfield
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11189-93.
2010: Ke Wang; Weixue Wang; Joo-Hwan No; Yong Zhang; Yonghui Zhang; Eric Oldfield
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.
Journal of the American Chemical Society 2010;132(19):6719-27.
2010: Weixue Wang; Ke Wang; Yi-Liang Liu; Joo-Hwan No; Jikun Li; Mark Joseph Nilges; Eric Oldfield
Bioorganometallic mechanism of action, and inhibition, of IspH.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(10):4522-7.
2010: Chuan-Hsiang Huang; Sandra B. Gabelli; Eric Oldfield; Mario Amzel
Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.
Proteins 2010;78(4):888-99.
2010: Yonghui Zhang; Rong Cao; Fenglin Yin; Fu-Yang Lin; Hong Wang; Kilannin Krysiak; Joo-Hwan No; Dushyant Mukkamala; Kevin Houlihan; Jikun Li; Craig Morita; Eric Oldfield
Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.
Angewandte Chemie (International ed. in English) 2010;49(6):1136-8.
2009: Yongcheng Song; Chia-I Liu; Fu-Yang Lin; Joo Hwan No; Mary Hensler; Yi-Liang Liu; Wen-Yih Jeng; Jennifer Low; George Y Liu; Victor Nizet; Andrew H-J Wang; Eric Oldfield
Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Journal of medicinal chemistry 2009;52(13):3869-80.
2009: Sujoy Mukherjee; Cancan Huang; Francisco Guerra; Ke Wang; Eric Oldfield
Thermodynamics of bisphosphonates binding to human bone: a two-site model.
Journal of the American Chemical Society 2009;131(24):8374-5.
2009: Yonghui Zhang; Rong Cao; Fenglin Yin; Michael P Hudock; Rey-Ting Guo; Kilannin Krysiak; Sujoy Mukherjee; Yi-Gui Gao; Howard Robinson; Yongcheng Song; Joo Hwan No; Kyle Bergan; Annette Leon; Lauren Cass; Amanda Goddard; Ting-Kai Chang; Fu-Yang Lin; Ermond van Beek; Socrates Papapoulos; Andrew H-J Wang; Tadahiko Kubo; Mitsuo Ochi; Dushyant Mukkamala; Eric Oldfield
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
Journal of the American Chemical Society 2009;131(14):5153-62.
2009: Yongcheng Song; Fu-Yang Lin; Fenglin Yin; Mary Hensler; Carlos A Rodrígues Poveda; Dushyant Mukkamala; Rong Cao; Hong Wang; Craig Morita; Dolores González-Pacanowska; Victor Nizet; Eric Oldfield
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Journal of medicinal chemistry 2009;52(4):976-88.
2009: Benjamin J Wylie; Charles D Schwieters; Eric Oldfield; Chad M Rienstra
Protein structure refinement using 13C alpha chemical shift tensors.
Journal of the American Chemical Society 2009;131(3):985-92.
2008: Ghanashyam Sarikonda; Hong Wang; Kia-Joo Puan; Xiao-hui Liu; Hoi K Lee; Yongcheng Song; Mark D Distefano; Eric Oldfield; Glenn D Prestwich; Craig Morita
Photoaffinity antigens for human gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7738-50.
2008: Rong Cao; Cammy K-M Chen; Rey-Ting Guo; Andrew H-J Wang; Eric Oldfield
Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Proteins 2008;73(2):431-9.
2008: Yongcheng Song; Julian M W Chan; Zev Tovian; Aaron Secrest; Eva Nagy; Kilannin Krysiak; Kyle Bergan; Michael A Parniak; Eric Oldfield
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.
Bioorganic & medicinal chemistry 2008;16(19):8959-67.
2008: Cammy K-M Chen; Michael P Hudock; Yonghui Zhang; Rey-Ting Guo; Rong Cao; Joo Hwan No; Po-Huang Liang; Tzu-Ping Ko; Tao-Hsin Chang; Shiou-Chi Chang; Yongcheng Song; Jordan Axelson; Anup Kumar; Andrew H-J Wang; Eric Oldfield
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.
Journal of medicinal chemistry 2008;51(18):5594-607.
2008: Yong Zhang; Eric Oldfield
NMR hyperfine shifts in blue copper proteins: a quantum chemical investigation.
Journal of the American Chemical Society 2008;130(12):3814-23.
2008: Sujoy Mukherjee; Yongcheng Song; Eric Oldfield
NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model.
Journal of the American Chemical Society 2008;130(4):1264-73.
2007: Panakkattu K Babu; Adam Lewera; Jong Ho Chung; Ralf Hunger; Wolfram Jaegermann; Nicolas Alonso-Vante; Andrzej Wieckowski; Eric Oldfield
Selenium becomes metallic in Ru-Se fuel cell catalysts: an EC-NMR and XPS investigation.
Journal of the American Chemical Society 2007;129(49):15140-1.
2007: Yonghui Zhang; Michael P Hudock; Kilannin Krysiak; Rong Cao; Kyle Bergan; Fenglin Yin; Annette Leon; Eric Oldfield
Activity of sulfonium bisphosphonates on tumor cell lines.
Journal of medicinal chemistry 2007;50(24):6067-79.
2007: Yan Ling; Zhu-Hong Li; Kildare Miranda; Eric Oldfield; Silvia N J Moreno
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.
The Journal of biological chemistry 2007;282(42):30804-16.
2007: Dushyant Mukkamala; Yong Zhang; Eric Oldfield
A solid state 13C NMR, crystallographic, and quantum chemical investigation of phenylalanine and tyrosine residues in dipeptides and proteins.
Journal of the American Chemical Society 2007;129(23):7385-92.
2007: Rey-Ting Guo; Rong Cao; Po-Huang Liang; Tzu-Ping Ko; Tao-Hsin Chang; Michael P Hudock; Wen-Yih Jeng; Cammy K-M Chen; Yonghui Zhang; Yongcheng Song; Chih-Jung Kuo; Fenglin Yin; Eric Oldfield; Andrew H-J Wang
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10022-7.
2006: Annette Leon; Lei Liu; Yan Yang; Michael P Hudock; Patrick Hall; Fenglin Yin; Danielle Studer; Kia-Joo Puan; Craig Morita; Eric Oldfield
Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.
Journal of medicinal chemistry 2006;49(25):7331-41.
2006: Evangelia Kotsikorou; Gurmukh Sahota; Eric Oldfield
Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation.
Journal of medicinal chemistry 2006;49(23):6692-703.
2006: Junhong Mao; Sujoy Mukherjee; Yong Zhang; Rong Cao; John M Sanders; Yongcheng Song; Yonghui Zhang; Gary A Meints; Yi-Gui Gao; Dushyant Mukkamala; Michael P Hudock; Eric Oldfield
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
Journal of the American Chemical Society 2006;128(45):14485-97.
2006: Hiroshi Yano; Junji Inukai; Hiroyuki Uchida; Masahiro Watanabe; Panakkattu K Babu; Takeshi Kobayashi; Jong Ho Chung; Eric Oldfield; Andrzej Wieckowski
Particle-size effect of nanoscale platinum catalysts in oxygen reduction reaction: an electrochemical and 195Pt EC-NMR study.
Physical chemistry chemical physics : PCCP 2006;8(42):4932-9.
2006: Yonghui Zhang; Annette Leon; Yongcheng Song; Danielle Studer; Christa Haase; Lukasz A Koscielski; Eric Oldfield
Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines.
Journal of medicinal chemistry 2006;49(19):5804-14.
2006: Yonghui Zhang; Yongcheng Song; Fenglin Yin; Erin Broderick; Kathryn Siegel; Amanda Goddard; Edward Nieves; Ljiljana Pasa-Tolic; Yoshimasa Tanaka; Hong Wang; Craig Morita; Eric Oldfield
Structural studies of Vgamma2Vdelta2 T cell phosphoantigens.
Chemistry & biology 2006;13(9):985-92.
2006: Fenglin Yin; Rong Cao; Amanda Goddard; Yonghui Zhang; Eric Oldfield
Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.
Journal of the American Chemical Society 2006;128(11):3524-5.
2006: Gustavo Benaim; John M Sanders; Yael Garcia-Marchán; Claudia Colina; Renee Lira; Aura Caldera; gilberto payares; cristina sanoja; Juan M Burgos; Annette Leon-Rossell; Juan Luis Concepcion; Alejandro G Schijman; Mariano Levin; Eric Oldfield; Julio A Urbina
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Journal of medicinal chemistry 2006;49(3):892-9.
2006: Yong Zhang; Eric Oldfield
31P NMR chemical shifts in hypervalent oxyphosphoranes and polymeric orthophosphates.
The journal of physical chemistry. B 2006;110(1):579-86.
2006: Michael P Hudock; Carlos Sanz-Rodríguez; Yongcheng Song; Julian M W Chan; Yonghui Zhang; Sarah Odeh; Thomas Kosztowski; Annette Leon-Rossell; J L Concepción; Vanessa Yardley; Simon L Croft; Julio A Urbina; Eric Oldfield
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Journal of medicinal chemistry 2006;49(1):215-23.
2006: Sandra B. Gabelli; Jason S McLellan; Andrea Montalvetti; Eric Oldfield; Roberto Docampo; Mario Amzel
Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.
Proteins 2006;62(1):80-8.
2005: Takeshi Kobayashi; Panakkattu K Babu; Lajos Gancs; Jong Ho Chung; Eric Oldfield; Andrzej Wieckowski
An NMR determination of CO diffusion on platinum electrocatalysts.
Journal of the American Chemical Society 2005;127(41):14164-5.
2005: Evangelia Kotsikorou; Yongcheng Song; Julian M W Chan; Stephanie Faelens; Zev Tovian; Erin Broderick; Norbert Bakalara; Roberto Docampo; Eric Oldfield
Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.
Journal of medicinal chemistry 2005;48(19):6128-39.
2005: Panakkattu K Babu; Hee Soo Kim; Seung Taek Kuk; Jong Ho Chung; Eric Oldfield; Andrzej Wieckowski; Eugene S Smotkin
Activation of nanoparticle Pt-Ru fuel cell catalysts by heat treatment: a 195Pt NMR and electrochemical study.
The journal of physical chemistry. B 2005;109(36):17192-6.
2005: Feng Cheng; Haihong Sun; Yong Zhang; Dushyant Mukkamala; Eric Oldfield
A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides.
Journal of the American Chemical Society 2005;127(36):12544-54.
2005: Eric Oldfield
Quantum chemical studies of protein structure.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1458):1347-61.
2005: Yan Ling; Gurmukh Sahota; Sarah Odeh; Julian M W Chan; Fausto G Araujo; Silvia N J Moreno; Eric Oldfield
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Journal of medicinal chemistry 2005;48(9):3130-40.
2005: John M Sanders; Yongcheng Song; Julian M W Chan; Yonghui Zhang; Samuel Jennings; Thomas Kosztowski; Sarah Odeh; Ryan Flessner; Christine Schwerdtfeger; Evangelia Kotsikorou; Gary A Meints; Aurora Ortiz Gómez; Dolores González-Pacanowska; Amy M Raker; Hong Wang; Ermond R Van Beek; Socrates E Papapoulos; Craig Morita; Eric Oldfield
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Journal of medicinal chemistry 2005;48(8):2957-63.
2005: Yong Zhang; Haihong Sun; Eric Oldfield
Solid-state NMR fermi contact and dipolar shifts in organometallic complexes and metalloporphyrins.
Journal of the American Chemical Society 2005;127(11):3652-3.
2005: Yong Zhang; Sujoy Mukherjee; Eric Oldfield
(67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation.
Journal of the American Chemical Society 2005;127(8):2370-1.
2005: Panakkattu K Babu; Jong Ho Chung; Seung Taek Kuk; Takeshi Kobayashi; Eric Oldfield; Andrzej Wieckowski
Metallic nature and surface diffusion of CO adsorbed on Ru nanoparticles in aqueous media: A 13C NMR study.
The journal of physical chemistry. B 2005;109(7):2474-7.
2004: Manfredo Seufferheld; Christopher R Lea; Mauricio Vieira; Eric Oldfield; Roberto Docampo
The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes.
The Journal of biological chemistry 2004;279(49):51193-202.
2004: Felix A Ruiz; Christopher R Lea; Eric Oldfield; Roberto Docampo
Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.
The Journal of biological chemistry 2004;279(43):44250-7.
2004: Feng Cheng; Eric Oldfield
Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates.
Journal of medicinal chemistry 2004;47(21):5149-58.
2004: Junhong Mao; Yi-Gui Gao; Sarah Odeh; Howard Robinson; Andrea Montalvetti; Roberto Docampo; Eric Oldfield
Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1863-6.
2004: Yongcheng Song; Yonghui Zhang; Hong Wang; Amy M Raker; John M Sanders; Erin Broderick; Allen Clark; Craig Morita; Eric Oldfield
Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation.
Bioorganic & medicinal chemistry letters 2004;14(17):4471-7.
2004: Yong Zhang; Eric Oldfield
On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system.
Journal of the American Chemical Society 2004;126(31):9494-5.
2004: Haihong Sun; Eric Oldfield
Tryptophan chemical shift in peptides and proteins: a solid state carbon-13 nuclear magnetic resonance spectroscopic and quantum chemical investigation.
Journal of the American Chemical Society 2004;126(14):4726-34.
2004: Yong Zhang; Eric Oldfield
Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system.
Journal of the American Chemical Society 2004;126(14):4470-1.
2004: Luciana R Garzoni; Mariana C Waghabi; Marcos M Baptista; Solange L de Castro; Maria de Nazareth L Meirelles; Constança Britto; Roberto Docampo; Eric Oldfield; Julio A Urbina
Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.
International journal of antimicrobial agents 2004;23(3):286-90.
2004: Luciana R Garzoni; Aura Caldera; Maria de Nazareth L Meirelles; Solange L de Castro; Roberto Docampo; Gary A Meints; Eric Oldfield; Julio A Urbina
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi.
International journal of antimicrobial agents 2004;23(3):273-85.
2004: John M Sanders; Subhash Ghosh; Julian M W Chan; Gary A Meints; Hong Wang; Amy M Raker; Yongcheng Song; Alison Colantino; Agnieszka Burzynska; Pawel Kafarski; Craig Morita; Eric Oldfield
Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.
Journal of medicinal chemistry 2004;47(2):375-84.
2004: Subhash Ghosh; Julian M W Chan; Christopher R Lea; Gary A Meints; Jared C Lewis; Zev S Tovian; Ryan M Flessner; Timothy C Loftus; Iris Bruchhaus; Howard Kendrick; Simon L Croft; Robert G Kemp; Seiki Kobayashi; Tomoyoshi Nozaki; Eric Oldfield
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Journal of medicinal chemistry 2004;47(1):175-87.
2003: Yong Zhang; William L Gossman; Eric Oldfield
A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems.
Journal of the American Chemical Society 2003;125(52):16387-96.
2003: John M Sanders; Aurora Ortiz Gómez; Junhong Mao; Gary A Meints; Erin M Van Brussel; Agnieszka Burzynska; Pawel Kafarski; Dolores González-Pacanowska; Eric Oldfield
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.
Journal of medicinal chemistry 2003;46(24):5171-83.
2003: Evangelia Kotsikorou; Eric Oldfield
A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents.
Journal of medicinal chemistry 2003;46(14):2932-44.
2003: Andrea Montalvetti; Alexis Fernandez; John M Sanders; Subhash Ghosh; Erin M Van Brussel; Eric Oldfield; Roberto Docampo
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies.
The Journal of biological chemistry 2003;278(19):17075-83.
2003: Erin M Van Brussel; William L Gossman; Scott R Wilson; Eric Oldfield
Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate).
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 2):o93-4.
2003: William L Gossman; Scott R Wilson; Eric Oldfield
Three hydrates of the bisphosphonate risedronate, consisting of one molecular and two ionic structures.
Acta crystallographica. Section C, Crystal structure communications 2003;59(Pt 2):m33-6.
2002: William L Gossman; Scott R Wilson; Eric Oldfield
Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]bis(phosphonate) tetrahydrate (monosodium isozoledronate).
Acta crystallographica. Section C, Crystal structure communications 2002;58(Pt 12):m599-600.
2002: Yong Zhang; Junhong Mao; Nathalie Godbout; Eric Oldfield
Mössbauer quadrupole splittings and electronic structure in heme proteins and model systems: a density functional theory investigation.
Journal of the American Chemical Society 2002;124(46):13921-30.
2002: Junhong Mao; Yong Zhang; Eric Oldfield
Nuclear magnetic resonance shifts in paramagnetic metalloporphyrins and metalloproteins.
Journal of the American Chemical Society 2002;124(46):13911-20.
2002: William L Gossman; Eric Oldfield
Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens.
Journal of medicinal chemistry 2002;45(22):4868-74.
2002: Benjamin Moreno; Claudia Rodrigues; Brian N Bailey; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.
FEBS letters 2002;523(1-3):207-12.
2002: Michael B Martin; John M Sanders; Howard Kendrick; Kate de Luca-Fradley; Jared C Lewis; Joshua S Grimley; Erin M Van Brussel; Jeffrey R Olsen; Gary A Meints; Agnieszka Burzynska; Pawel Kafarski; Simon L Croft; Eric Oldfield
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.
Journal of medicinal chemistry 2002;45(14):2904-14.
2002: Christina M Szabo; Michael B Martin; Eric Oldfield
An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs.
Journal of medicinal chemistry 2002;45(14):2894-903.
2002: Yong Zhang; Junhong Mao; Eric Oldfield
(57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations.
Journal of the American Chemical Society 2002;124(26):7829-39.
2002: Noris Rodriguez; Brian N Bailey; Michael B Martin; Eric Oldfield; Julio A Urbina; Roberto Docampo
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate.
The Journal of infectious diseases 2002;186(1):138-40.
2002: Christina M Szabo; Yoshihiro Matsumura; Sayaka Fukura; Michael B Martin; John M Sanders; Suraj Sengupta; John A Cieslak; Timothy C Loftus; Christopher R Lea; Hyung-Jae Lee; Ali Koohang; Robert M Coates; Hiroshi Sagami; Eric Oldfield
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Journal of medicinal chemistry 2002;45(11):2185-96.
2002: Haihong Sun; Lori K Sanders; Eric Oldfield
Carbon-13 NMR shielding in the twenty common amino acids: comparisons with experimental results in proteins.
Journal of the American Chemical Society 2002;124(19):5486-95.
2002: Vanessa Yardley; Anis A Khan; Michael B Martin; Teri Slifer; Fausto G Araujo; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.
Antimicrobial agents and chemotherapy 2002;46(3):929-31.
2002: YuYe Tong; Hee Soo Kim; Panakkattu K Babu; Piotr Waszczuk; Andrzej Wieckowski; Eric Oldfield
An NMR investigation of CO tolerance in a Pt/Ru fuel cell catalyst.
Journal of the American Chemical Society 2002;124(3):468-73.
2002: Eric Oldfield
Chemical shifts in amino acids, peptides, and proteins: from quantum chemistry to drug design.
Annual review of physical chemistry 2002;53():349-78.
2001: R H Havlin; David D Laws; Hans-Marcus L Bitter; Lori K Sanders; Haihong Sun; Joshua S Grimley; David E Wemmer; Alexander Pines; Eric Oldfield
An experimental and theoretical investigation of the chemical shielding tensors of (13)C(alpha) of alanine, valine, and leucine residues in solid peptides and in proteins in solution.
Journal of the American Chemical Society 2001;123(42):10362-9.
2001: C M Szabo; Eric Oldfield
An investigation of bisphosphonate inhibition of a vacuolar proton-pumping pyrophosphatase.
Biochemical and biophysical research communications 2001;287(2):468-73.
2001: Andrea Montalvetti; Brian N Bailey; Michael B Martin; G W Severin; Eric Oldfield; Roberto Docampo
Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.
The Journal of biological chemistry 2001;276(36):33930-7.
2001: Benjamin Moreno; Brian N Bailey; Shuhong Luo; Michael B Martin; Mark S Kuhlenschmidt; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
(31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth.
Biochemical and biophysical research communications 2001;284(3):632-7.
2001: Michael B Martin; Joshua S Grimley; Jared C Lewis; H T Heath; Brian N Bailey; Howard Kendrick; Vanessa Yardley; Aura Caldera; Renee Lira; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Journal of medicinal chemistry 2001;44(6):909-16.
2000: C M Szabo; Lori K Sanders; H C Le; E Y Chien; Eric Oldfield
Expression of doubly labeled Saccharomyces cerevisiae iso-1 ferricytochrome c and (1)H, (13)C and (15)N chemical shift assignments by multidimensional NMR.
FEBS letters 2000;482(1-2):25-30.
2000: Benjamin Moreno; Julio A Urbina; Eric Oldfield; Brian N Bailey; Claudia Rodrigues; Roberto Docampo
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates.
The Journal of biological chemistry 2000;275(37):28356-62.
2000: Claudia Rodrigues; David A Scott; Brian N Bailey; Wanderley de Souza; Marlene Benchimol; Benjamin Moreno; Julio A Urbina; Eric Oldfield; Silvia N J Moreno
Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets.
The Biochemical journal 2000;349 Pt 3():737-45.
1999: Julio A Urbina; Benjamin Moreno; S Vierkotter; Eric Oldfield; gilberto payares; cristina sanoja; Brian N Bailey; W Yan; David A Scott; Silvia N J Moreno; Roberto Docampo
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.
The Journal of biological chemistry 1999;274(47):33609-15.
1999: Michael B Martin; W Arnold; H T Heath; Julio A Urbina; Eric Oldfield
Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis.
Biochemical and biophysical research communications 1999;263(3):754-8.
1999: Michael McMahon; Eric Oldfield
Determination of order parameters and correlation times in proteins: a comparison between Bayesian, Monte Carlo and simple graphical methods.
Journal of biomolecular NMR 1999;13(2):133-7.
1998: J A Urbina; B Moreno; W Arnold; Christopher H Taron; Peter Orlean; Eric Oldfield
A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems.
Biophysical journal 1998;75(3):1372-83.
1997: J G Pearson; B Montez; H Le; Eric Oldfield; E Y Chien; Stephen G Sligar
Assignment and analysis of fluorine nuclear magnetic resonance spectra of 4-fluorotryptophan myoglobins and hemoglobins.
Biochemistry 1997;36(12):3590-9.
1996: A C de Dios; Eric Oldfield
Recent progress in understanding chemical shifts.
Solid state nuclear magnetic resonance 1996;6(2):101-25.
1995: Julio A Urbina; S Pekerar; H B Le; J Patterson; B Montez; Eric Oldfield
Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy.
Biochimica et biophysica acta 1995;1238(2):163-76.
1995: Eric Oldfield
Chemical shifts and three-dimensional protein structures.
Journal of biomolecular NMR 1995;5(3):217-25.
1995: A K Jameson; C J Jameson; A C de Dios; Eric Oldfield; R E Gerald; G L Turner
129Xe magic-angle spinning spectra of xenon in zeolite NaA. Direct observation of mixed clusters of co-adsorbed species.
Solid state nuclear magnetic resonance 1995;4(1):1-12.
1994: J Haase; Eric Oldfield
Aluminum to oxygen cross-polarization in alpha-Al2O3 (corundum).
Solid state nuclear magnetic resonance 1994;3(3):171-5.
1994: C Lian; H Le; B Montez; J Patterson; S Harrell; D Laws; I Matsumura; J Pearson; Eric Oldfield
Fluorine-19 nuclear magnetic resonance spectroscopic study of fluorophenylalanine- and fluorotryptophan-labeled avian egg white lysozymes.
Biochemistry 1994;33(17):5238-45.
1994: H Le; Eric Oldfield
Correlation between 15N NMR chemical shifts in proteins and secondary structure.
Journal of biomolecular NMR 1994;4(3):341-8.
1993: B Montez; Eric Oldfield; Julio A Urbina; S Pekerar; C Husted; J Patterson
Editing 13C-NMR spectra of membranes.
Biochimica et biophysica acta 1993;1152(2):314-8.
1993: D D Laws; A C de Dios; Eric Oldfield
NMR chemical shifts and structure refinement in proteins.
Journal of biomolecular NMR 1993;3(5):607-12.
1993: A C de Dios; J G Pearson; Eric Oldfield
Secondary and tertiary structural effects on protein NMR chemical shifts: an ab initio approach.
Science (New York, N.Y.) 1993;260(5113):1491-6.
1993: C Husted; B Montez; C Le; M A Moscarello; Eric Oldfield
Carbon-13 "magic-angle" sample-spinning nuclear magnetic resonance studies of human myelin, and model membrane systems.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1993;29(2):168-78.
1992: F Adebodun; J Chung; B Montez; Eric Oldfield; X Shan
Spectroscopic studies of lipids and biological membranes: carbon-13 and proton magic-angle sample-spinning nuclear magnetic resonance study of glycolipid-water systems.
Biochemistry 1992;31(18):4502-9.
1991: Eric Oldfield; F Adebodun; J Chung; B Montez; K D Park; H B Le; B Phillips
Carbon-13 nuclear magnetic resonance spectroscopy of lipids: differential line broadening due to cross-correlation effects as a probe of membrane structure.
Biochemistry 1991;30(46):11025-8.
1991: K D Park; K M Guo; F Adebodun; M L Chiu; Stephen G Sligar; Eric Oldfield
Distal and proximal ligand interactions in heme proteins: correlations between C-O and Fe-C vibrational frequencies, oxygen-17 and carbon-13 nuclear magnetic resonance chemical shifts, and oxygen-17 nuclear quadrupole coupling constants in C17O- and 13CO-labeled species.
Biochemistry 1991;30(9):2333-47.
1988: H C Lee; K Cummings; K Hall; Lowell P Hager; Eric Oldfield
Oxygen-17 nuclear magnetic resonance spectroscopic studies of carbonmonoxyperoxidases.
The Journal of biological chemistry 1988;263(31):16118-24.
1987: Eric Oldfield; J L Bowers; J Forbes
High-resolution proton and carbon-13 NMR of membranes: why sonicate?
Biochemistry 1987;26(22):6919-23.
1982: M D Meadows; K A Smith; R A Kinsey; T M Rothgeb; R P Skarjune; Eric Oldfield
High-resolution solid-state NMR of quadrupolar nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1351-5.
1978: Eric Oldfield; R Gilmore; Michael Glaser; H S Gutowsky; J C Hshung; S Y Kang; T E King; M Meadows; D Rice
Deuterium nuclear magnetic resonance investigation of the effects of proteins and polypeptides on hydrocarbon chain order in model membrane systems.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(10):4657-60.