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Jerrold Olefsky

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Chemicals & Drugs

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Glucose Clamp Technique

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Shweta Sharma; Nissi Varki; Wuqiang Fan; Marina O Fernandez; Vicky Hwang; Hidetaka Morinaga; Jerrold M Olefsky; Nicholas J G Webster
Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice.
Min Lu; Hidetaka Morinaga; Gautam Bandyopadhyay; Ai Chen; KC Dines; Karl Kaiyala; Pingping Li; Olivia Osborn; Manuel Sanchez-Alavez; David A Sarruf; Michael W Schwartz; Saswata Talukdar; Steven Watkins; Jianfeng Xu; Jerrold M Olefsky
Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.
Jian Jiao; Chaitra Marathe; Jerrold M Olefsky; Jason Oliver; Eun Ju Bae; Gautam Bandyopadhyay; Michael Chen; Yu Chen; Jer-Yuan Hsu; Hui Tian; Maziyar Saberi
Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.

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All Publications

2013: Shweta Sharma; Nissi Varki; Wuqiang Fan; Marina O Fernandez; Vicky Hwang; Hidetaka Morinaga; Jerrold M Olefsky; Nicholas J G Webster
Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice.
Endocrinology 2013;154(6):2188-99.
2013: Min Lu; Hidetaka Morinaga; Gautam Bandyopadhyay; Ai Chen; KC Dines; Karl Kaiyala; Pingping Li; Olivia Osborn; Manuel Sanchez-Alavez; David A Sarruf; Michael W Schwartz; Saswata Talukdar; Steven Watkins; Jianfeng Xu; Jerrold M Olefsky
Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.
The Journal of biological chemistry 2013;288(15):10722-35.
2013: Jian Jiao; Chaitra Marathe; Jerrold M Olefsky; Jason Oliver; Eun Ju Bae; Gautam Bandyopadhyay; Michael Chen; Yu Chen; Jer-Yuan Hsu; Hui Tian; Maziyar Saberi
Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.
Diabetes 2013;62(4):1074-83.
2013: Shannon M Reilly; John R Rubin; Maeran Uhm; Nicole M White; Ruth T Yu; Louise Chang; Shian-Huey Chiang; Stuart J Decker; Michael Downes; Ronald M Evans; Irit Hochberg; Martha J Larsen; Pingping Li; Christopher Liddle; Jonathan Mowers; Dayoung Oh; Jerrold M Olefsky; Alan R Saltiel
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.
Nature medicine 2013;19(3):313-21.
2013: Mohammed Qatanani; Dorothy D Sears; Yejun Tan; Wenqing Zhao; Radu Dobrin; Danielle M Greenawalt; Guanghui Hu; Lee M Kaplan; Jerrold M Olefsky; Daniel M Kemp
Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients.
Diabetes 2013;62(3):855-63.
2013: Andrew M F Johnson; Jerrold M Olefsky
The origins and drivers of insulin resistance.
Cell 2013;152(4):673-84.
2012: Saswata Talukdar; Jianfeng Xu; Qingyun Yan; Yimin Zhu; Gautam K Bandyopadhyay; Martin B Brenner; Dongmei Li; Pingping Li; Michael Lin; Min Lu; Joanne McNelis; Jachelle Ofrecio; Da Young Oh; Jerrold M Olefsky
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
Nature medicine 2012;18(9):1407-12.
2012: Jianfeng Xu; Yaël Mamane; Joseph A Mancini; Andrea R Nawrocki; Eduardo R Lazarowski; Pingping Li; Hidetaka Morinaga; Dayoung Oh; Jerrold M Olefsky; Saswata Talukdar; Ai Chen; Jane J Kim
GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1992-9.
2012: Jan Heinrichsdorff; Jerrold M Olefsky
Fetuin-A: the missing link in lipid-induced inflammation.
Nature medicine 2012;18(8):1182-3.
2012: Olivia Osborn; Manuel Sanchez-Alavez; Miriam Scadeng; Simon Schenk; Saswata Talukdar; Lucinda Thiede; Da Young Oh; Tamas Bartfai; John Hadcock; Jan Heinrichsdorff; Jane J Kim; Pingping Li; Min Lu; Joanne McNelis; Hidetaka Morinaga; Sarah Nalbandian; Jachelle M Ofrecio; Jerrold M Olefsky
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
The Journal of clinical investigation 2012;122(7):2444-53.
2012: Eun Ju Bae; Gautam Bandyopadhyay; Malik Keshwani; William S Lagakos; Jianfeng Xu; Da Young Oh; Jerrold M Olefsky
Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance.
The Journal of biological chemistry 2012;287(22):18769-80.
2012: johan jonker; Henry Juguilon; Pingping Li; Jerrold M Olefsky; Colin T Phillips; Jae Myoung Suh; Jamie Whyte; Yun-Qiang Yin; Ruth T Yu; Maryam Ahmadian; Annette R Atkins; Michael Downes; Mingxiao He; Robert R Henry; Ronald M Evans
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Nature 2012;485(7398):391-4.
2012: Jane J Kim; Wuqiang Fan; Jerrold M Olefsky
Putting the brakes on FOXO1 in fat.
The EMBO journal 2012;31(10):2240-1.
2012: Christopher K Glass; Jerrold M Olefsky
Inflammation and lipid signaling in the etiology of insulin resistance.
Cell metabolism 2012;15(5):635-45.
2012: Da Young Oh; Jerrold M Olefsky
Omega 3 fatty acids and GPR120.
Cell metabolism 2012;15(5):564-5.
2012: Bernat Baeza-Raja; Dave Bridges; Dimitrios Davalos; Choel Kim; Natacha Le Moan; Pingping Li; Jerrold M Olefsky; Benjamin D Sachs; Alan R Saltiel; Christian Schachtrup; Eirini Vagena; Katerina Akassoglou
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(15):5838-43.
2012: Olivia Osborn; Jerrold M Olefsky
The cellular and signaling networks linking the immune system and metabolism in disease.
Nature medicine 2012;18(3):363-74.
2012: Da Young Oh; Saswata Talukdar; Eun Ju Bae; Hidetaka Morinaga; Jerrold M Olefsky
Increased macrophage migration into adipose tissue in obese mice.
Diabetes 2012;61(2):346-54.
2011: Matthew P Gillum; Jennifer J Hsiao; Maya E Kotas; Romy Kursawe; Eric S Muise; Kevin T Nead; Jerrold M Olefsky; Li Qiang; Dorothy D Sears; Alexander S Banks; Sanjay Bhanot; Sonia Caprio; Paula Chatterjee; Derek M Erion; David W Frederick; Shin Yonemitsu; Gerald I Shulman
SirT1 regulates adipose tissue inflammation.
Diabetes 2011;60(12):3235-45.
2011: Pingping Li; Min Lu; Sarah Nalbandian; Jachelle Ofrecio; DaYoung Oh; Johan Auwerx; Gautam K Bandyopadhyay; Ai Chen; Wuqiang Fan; Miriam Scadeng; Dorothy D Sears; Saswata Talukdar; Jianfeng Xu; Hiroyasu Yamamoto; Jerrold M Olefsky
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity.
Cell 2011;147(4):815-26.
2011: Simon Schenk; Olivia Osborn; Andrew Philp; Keith Baar; Gautum K Bandyopadhyay; Mark Z Chen; Michael J Holliday; Carrie E McCurdy; Jerrold M Olefsky
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.
The Journal of clinical investigation 2011;121(11):4281-8.
2011: Kazuaki Ohtsubo; Jerrold M Olefsky; Mark Z Chen; Jamey D Marth
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
Nature medicine 2011;17(9):1067-75.
2011: Saswata Talukdar; Jerrold M Olefsky; Olivia Osborn
Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.
Trends in pharmacological sciences 2011;32(9):543-50.
2011: Debin Lan; Min Lu; Pamela L Mellon; Jerrold M Olefsky; Shweta Sharma; Nicholas J G Webster
Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.
Reproductive toxicology (Elmsford, N.Y.) 2011;32(1):85-92.
2011: Min Lu; David A Sarruf; Saswata Talukdar; Shweta Sharma; Pingping Li; Gautam K Bandyopadhyay; Sarah Nalbandian; WuQiang Fan; Jiaur R Gayen; Sushil K Mahata; Nicholas J Webster; Michael W Schwartz; Jerrold M Olefsky
Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones.
Nature medicine 2011;17(5):618-22.
2011: Yosuke Osawa; Ekihiro Seki; Yuzo Kodama; Atsushi Suetsugu; Kouichi Miura; Masayuki Adachi; Hiroyasu Ito; Yoshimune Shiratori; Yoshiko Banno; Jerrold M Olefsky; Masahito Nagaki; Hisataka Moriwaki; David A Brenner; Mitsuru Seishima
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1133-44.
2011: Shweta Sharma; Prem M Sharma; Devendra S Mistry; R Jeffery Chang; Jerrold M Olefsky; Pamela L Mellon; Nicholas J G Webster
PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice.
Biology of reproduction 2011;84(3):466-75.
2010: Wuqiang Fan; Hidetaka Morinaga; Jane J Kim; Eunju Bae; Nathanael J Spann; Sven Heinz; Christopher K Glass; Jerrold M Olefsky
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.
The EMBO journal 2010;29(24):4223-36.
2010: Olivia Osborn; Dorothy D Sears; Jerrold M Olefsky
Fat-induced inflammation unchecked.
Cell metabolism 2010;12(6):553-4.
2010: Da Young Oh; Saswata Talukdar; Eun Ju Bae; Takeshi Imamura; Hidetaka Morinaga; WuQiang Fan; Pingping Li; Wendell J Lu; Steven M Watkins; Jerrold M Olefsky
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Cell 2010;142(5):687-98.
2010: Da Young Oh; Jerrold M Olefsky
Medicine. Wnt fans the flames in obesity.
Science (New York, N.Y.) 2010;329(5990):397-8.
2010: Min Lu; PingPing Li; Jan Pferdekamper; WuQiang Fan; Maziyar Saberi; Simon Schenk; Jerrold M Olefsky
Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance.
Molecular endocrinology (Baltimore, Md.) 2010;24(7):1413-22.
2010: Kouichi Miura; Yuzo Kodama; Sayaka Inokuchi; Bernd Schnabl; Tomonori Aoyama; Hirohide Ohnishi; Jerrold M Olefsky; David A Brenner; Ekihiro Seki
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.
Gastroenterology 2010;139(1):323-34.e7.
2010: Pingping Li; Min Lu; M T Audrey Nguyen; Eun Ju Bae; Justin Chapman; Daorong Feng; Meredith Hawkins; Jeffrey Pessin; Dorothy D Sears; Anh-Khoi Nguyen; Arezou Amidi; Steven M Watkins; Uyenthao Nguyen; Jerrold M Olefsky
Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice.
The Journal of biological chemistry 2010;285(20):15333-45.
2010: Min Lu; David Patsouris; Pingping Li; Jaime Flores-Riveros; James M Frincke; Steve Watkins; Simon Schenk; Jerrold M Olefsky
A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E1036-48.
2010: Tianlun Wang; Sonia Villegas; Yujin Huang; Steven White; Clarence Ahlem; Min Lu; Jerrold M Olefsky; Christopher Reading; James M Frincke; David Alleva; Jaime Flores-Riveros
Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways.
The Journal of pharmacology and experimental therapeutics 2010;333(1):70-80.
2010: Takeshi Yoshizaki; Simon Schenk; Takeshi Imamura; Jennie L Babendure; Noriyuki Sonoda; Eun Ju Bae; Da Young Oh; Min Lu; Jill C Milne; Christoph Westphal; Gautam Bandyopadhyay; Jerrold M Olefsky
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E419-28.
2010: Jerrold M Olefsky; Christopher K Glass
Macrophages, inflammation, and insulin resistance.
Annual review of physiology 2010;72():219-46.
2009: Shigeki Sugii; Peter Olson; Dorothy D Sears; Maziyar Saberi; Annette R Atkins; Grant D Barish; Suk-Hyun Hong; Glenda L Castro; Yun-Qiang Yin; Michael C Nelson; Gene Hsiao; David Greaves; Michael Downes; Ruth T Yu; Jerrold M Olefsky; Ronald M Evans
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22504-9.
2009: David Patsouris; Jaap G Neels; WuQiang Fan; Ping-Ping Li; M T Audrey Nguyen; Jerrold M Olefsky
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment.
The Journal of biological chemistry 2009;284(45):31223-35.
2009: Maziyar Saberi; Niels-Bjarne Woods; Carl de Luca; Simon Schenk; Juu-Chin Lu; Gautam Bandyopadhyay; Inder M Verma; Jerrold M Olefsky
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.
Cell metabolism 2009;10(5):419-29.
2009: Maziyar Saberi; Simon Schenk; Chandra Vargeese; Weimin Wang; Ye Zhang; Gautam Bandyopadhyay; David Bjelica; Keith Bowman; Takeshi Imamura; Vasant Jadhar; Pingping Li; Barry Polisky; Jerrold M Olefsky
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1137-46.
2009: Jerrold M Olefsky
IKKepsilon: a bridge between obesity and inflammation.
Cell 2009;138(5):834-6.
2009: Jane J Kim; Pingping Li; Jessica Huntley; Jeffrey P Chang; Karen C Arden; Jerrold M Olefsky
FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.
Diabetes 2009;58(6):1275-82.
2009: Wuqiang Fan; Takeshi Imamura; Noriyuki Sonoda; Dorothy Sears; David Patsouris; Jane J Kim; Jerrold M Olefsky
FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes.
The Journal of biological chemistry 2009;284(18):12188-97.
2009: Chi B Vu; Jean E Bemis; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Jill C Milne; David P Carney; Amy V Lynch; Jesse J Smith; Siva Lavu; Philip D Lambert; David J Gagne; Michael R Jirousek; Simon Schenk; Jerrold M Olefsky; Robert B Perni
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
Journal of medicinal chemistry 2009;52(5):1275-83.
2009: Takeshi Yoshizaki; Jill C Milne; Takeshi Imamura; Simon Schenk; Noriyuki Sonoda; Jennie L Babendure; Juu-Chin Lu; Jesse J Smith; Michael R Jirousek; Jerrold M Olefsky
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
Molecular and cellular biology 2009;29(5):1363-74.
2008: David Patsouris; Ping-Ping Li; Divya Thapar; Justin Chapman; Jerrold M Olefsky; Jaap G Neels
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.
Cell metabolism 2008;8(4):301-9.
2008: Jerrold M Olefsky
Fat talks, liver and muscle listen.
Cell 2008;134(6):914-6.
2008: Simon Schenk; Maziyar Saberi; Jerrold M Olefsky
Insulin sensitivity: modulation by nutrients and inflammation.
The Journal of clinical investigation 2008;118(9):2992-3002.
2008: Chloé C Féral; Jaap G Neels; Christiane Kummer; Marina Slepak; Jerrold M Olefsky; Mark H Ginsberg
Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.
Diabetes 2008;57(7):1842-51.
2008: Noriyuki Sonoda; Takeshi Imamura; Takeshi Yoshizaki; Jennie L Babendure; Juu-Chin Lu; Jerrold M Olefsky
Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6614-9.
2008: Min Lu; Qingbo Tang; Jerrold M Olefsky; Pamela L Mellon; Nicholas J G Webster
Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):760-71.
2008: Xiaoyong Yang; Pat P Ongusaha; Philip D Miles; Joyce C Havstad; Fengxue Zhang; W Venus So; Jeffrey E Kudlow; Robert H Michell; Jerrold M Olefsky; Seth J Field; Ronald M Evans
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Nature 2008;451(7181):964-9.
2008: Carl de Luca; Jerrold M Olefsky
Inflammation and insulin resistance.
FEBS letters 2008;582(1):97-105.
2007: Dorothy Sears; Albert Hsiao; Jachelle M Ofrecio; Justin Chapman; Weimin He; Jerrold M Olefsky
Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.
Biochemical and biophysical research communications 2007;364(3):515-21.
2007: M T Audrey Nguyen; Svetlana Favelyukis; Anh-Khoi Nguyen; Donna Reichart; Peter A Scott; Alan Jenn; Ru Liu-Bryan; Christopher K Glass; Jaap G Neels; Jerrold M Olefsky
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
The Journal of biological chemistry 2007;282(48):35279-92.
2007: Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature 2007;450(7170):712-6.
2007: Giovanni Solinas; Cristian Vilcu; Jaap G Neels; Gautam K Bandyopadhyay; Jun-Li Luo; Willscott E (Scott) Naugler; Sergei Grivennikov; Anthony Wynshaw-Boris; Miriam Scadeng; Jerrold M Olefsky; Michael Karin
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.
Cell metabolism 2007;6(5):386-97.
2007: Yuji Kawamata; Takeshi Imamura; Jennie L Babendure; Juu-Chin Lu; Takeshi Yoshizaki; Jerrold M Olefsky
Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex.
The Journal of biological chemistry 2007;282(39):28549-56.
2007: Takeshi Yoshizaki; Takeshi Imamura; Jennie L Babendure; Juu-Chin Lu; Noriyuki Sonoda; Jerrold M Olefsky
Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.
Molecular and cellular biology 2007;27(14):5172-83.
2007: Wei Liao; M T Audrey Nguyen; Takeshi Yoshizaki; Svetlana Favelyukis; David Patsouris; Takeshi Imamura; Inder M Verma; Jerrold M Olefsky
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E219-27.
2007: Philip D Miles; Kai Treuner; Marc Latronica; Jerrold M Olefsky; Carrolee Barlow
Impaired insulin secretion in a mouse model of ataxia telangiectasia.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E70-4.
2007: Andrea L Hevener; Jerrold M Olefsky; Donna Reichart; M T Audrey Nguyen; Gautam Bandyopadyhay; Ho-Yin Leung; Matthew J Watt; Chris Benner; Mark A Febbraio; Anh-Khoi Nguyen; Brian Folian; Shankar Subramaniam; Frank J Gonzalez; Christopher K Glass; Mercedes Ricote
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
The Journal of clinical investigation 2007;117(6):1658-69.
2007: Lisa A Lesniewski; Sarah E Hosch; Jaap G Neels; Carl de Luca; Mohammad Pashmforoush; Carey N Lumeng; Shian-Huey Chiang; Miriam Scadeng; Alan Saltiel; Jerrold M Olefsky
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.
Nature medicine 2007;13(4):455-62.
2007: Jerrold M Olefsky
The US's changing competitiveness in the biomedical sciences.
The Journal of clinical investigation 2007;117(1):270-6.
2007: Christopher J Hupfeld; Jerrold M Olefsky
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins.
Annual review of physiology 2007;69():561-77.
2006: Gautam K Bandyopadhyay; Joseph G Yu; Jachelle Ofrecio; Jerrold M Olefsky
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects.
Diabetes 2006;55(8):2277-85.
2006: Sarah E Hosch; Jerrold M Olefsky; Jane J Kim
APPLied mechanics: uncovering how adiponectin modulates insulin action.
Cell metabolism 2006;4(1):5-6.
2006: Jaap G Neels; Jerrold M Olefsky
Cell signaling. A new way to burn fat.
Science (New York, N.Y.) 2006;312(5781):1756-8.
2006: Wei Liao; M T Audrey Nguyen; Takeshi Imamura; Oded Singer; Inder M Verma; Jerrold M Olefsky
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes.
Endocrinology 2006;147(5):2245-52.
2006: Soon Young Shin; Young Yil Bahk; Jesang Ko; Il Yup Chung; Young Seek Lee; Julian Downward; Hermann Eibel; Prem M Sharma; Jerrold M Olefsky; Young-Ho Kim; Bonghee Lee; Lee Young Han
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.
The EMBO journal 2006;25(5):1093-103.
2006: Chih-Hao Lee; Peter Olson; Andrea L Hevener; Isaac R Mehl; Ling-Wa Chong; Jerrold M Olefsky; Frank J Gonzalez; Jungyeob Ham; H. Kang; Jeffrey M Peters; Ronald M Evans
PPARdelta regulates glucose metabolism and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3444-9.
2006: Carl de Luca; Jerrold M Olefsky
Stressed out about obesity and insulin resistance.
Nature medicine 2006;12(1):41-2; discussion 42.
2006: Jaap G Neels; Jerrold M Olefsky
Inflamed fat: what starts the fire?
The Journal of clinical investigation 2006;116(1):33-5.
2005: Jie Huang; Takeshi Imamura; Jennie L Babendure; Juu-Chin Lu; Jerrold M Olefsky
Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(51):42300-6.
2005: Jason J Wilkes; M T Audrey Nguyen; Gautam K Bandyopadhyay; Elizabeth Nelson; Jerrold M Olefsky
Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E1015-22.
2005: Isao Usui; Takeshi Imamura; Jennie L Babendure; Hiroaki Satoh; Juu-Chin Lu; Christopher J Hupfeld; Jerrold M Olefsky
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2005;19(11):2760-8.
2005: M T Audrey Nguyen; Hiroaki Satoh; Svetlana Favelyukis; Jennie L Babendure; Takeshi Imamura; Juan I Sbodio; Jonathan Zalevsky; Bassil I Dahiyat; Nai-Wen Chi; Jerrold M Olefsky
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(42):35361-71.
2005: Jin Zhang; Christopher J Hupfeld; Susan S Taylor; Jerrold M Olefsky; Roger Y Tsien
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature 2005;437(7058):569-73.
2005: Lian-Sheng Li; Jennie L Babendure; Subhash C Sinha; Jerrold M Olefsky; Richard A Lerner
Synthesis and evaluation of photolabile insulin prodrugs.
Bioorganic & medicinal chemistry letters 2005;15(17):3917-20.
2005: Gautam K Bandyopadhyay; Joseph G Yu; Jachelle Ofrecio; Jerrold M Olefsky
Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.
Diabetes 2005;54(8):2351-9.
2005: Albert Hsiao; Trey Ideker; Jerrold M Olefsky; Shankar Subramaniam
VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data.
Nucleic acids research 2005;33(Web Server issue):W627-32.
2005: Hiroaki Satoh; M T Audrey Nguyen; Maria Trujillo; Takeshi Imamura; Isao Usui; Philipp E Scherer; Jerrold M Olefsky
Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats.
Diabetes 2005;54(5):1304-13.
2005: Emilie A Bard-Chapeau; Andrea L Hevener; Shinong Long; Eric Erquan Zhang; Jerrold M Olefsky; Gen-Sheng Feng
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Nature medicine 2005;11(5):567-71.
2005: Mark O Goodarzi; Kent D Taylor; Xiuqing Guo; Manuel J Quiñones; Jinrui Cui; Xiaohui Li; Tieu Hang; Huiying Yang; Edward Holmes; Willa A Hsueh; Jerrold M Olefsky; Jerome I Rotter
Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait.
Diabetes 2005;54(4):1222-7.
2005: Jason J Wilkes; Elizabeth Nelson; Melville Osborne; Keith T Demarest; Jerrold M Olefsky
Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats.
American journal of physiology. Endocrinology and metabolism 2005;288(3):E617-24.
2005: Melek C Arkan; Andrea L Hevener; Florian R Greten; Shin Maeda; Zhi-Wei Li; Jeffrey M Long; Anthony Wynshaw-Boris; Giuseppe Poli; Jerrold M Olefsky; Michael Karin
IKK-beta links inflammation to obesity-induced insulin resistance.
Nature medicine 2005;11(2):191-8.
2005: Prem M Sharma; Hyun-Shik Son; Satoshi Ugi; William Ricketts; Jerrold M Olefsky
Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):421-30.
2005: Christopher J Hupfeld; Jamie L Resnik; Satoshi Ugi; Jerrold M Olefsky
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors.
The Journal of biological chemistry 2005;280(2):1016-23.
2004: Isao Usui; Takeshi Imamura; Jie Huang; Hiroaki Satoh; Sudha K Shenoy; Robert J Lefkowitz; Christopher J Hupfeld; Jerrold M Olefsky
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
Molecular and cellular biology 2004;24(20):8929-37.
2004: Satoshi Ugi; Takeshi Imamura; Hiroshi Maegawa; Katsuya Egawa; Takeshi Yoshizaki; Kun Shi; Toshiyuki Obata; Yousuke Ebina; Atsunori Kashiwagi; Jerrold M Olefsky
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.
Molecular and cellular biology 2004;24(19):8778-89.
2004: Therese Wiedmer; Ji Zhao; Lilin Li; Quansheng Zhou; Andrea L Hevener; Jerrold M Olefsky; Linda K Curtiss; Peter J Sims
Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13296-301.
2004: Isao Usui; Takeshi Imamura; Hiroaki Satoh; Jie Huang; Jennie L Babendure; Christopher J Hupfeld; Jerrold M Olefsky
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation.
The EMBO journal 2004;23(14):2821-9.
2004: Hiroaki Satoh; M T Audrey Nguyen; Philip D G Miles; Takeshi Imamura; Isao Usui; Jerrold M Olefsky
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats.
The Journal of clinical investigation 2004;114(2):224-31.
2004: Takeshi Yoshizaki; Hiroshi Maegawa; Katsuya Egawa; Satoshi Ugi; Yoshihiko Nishio; Takeshi Imamura; Takayasu Kobayashi; Shinri Tamura; Jerrold M Olefsky; Atsunori Kashiwagi
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(21):22715-26.
2004: Seung-Hoi Koo; Hiroaki Satoh; Stephan Herzig; Chih-Hao Lee; Susan Hedrick; Rohit Kulkarni; Ronald M Evans; Jerrold M Olefsky; Marc Montminy
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
Nature medicine 2004;10(5):530-4.
2004: Jie Huang; Stanley H Hsia; Takeshi Imamura; Isao Usui; Jerrold M Olefsky
Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes.
Endocrinology 2004;145(4):1579-86.
2004: Utpal B Pajvani; Meredith Hawkins; Terry P Combs; Michael W Rajala; Thomas W Doebber; Joel P Berger; John A Wagner; Margaret Wu; Annemie Knopps; Anny H Xiang; Kristina M Utzschneider; Steven E Kahn; Jerrold M Olefsky; Thomas A Buchanan; Philipp E Scherer
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.
The Journal of biological chemistry 2004;279(13):12152-62.
2004: Tahir S Pillay; Sen Xiao; Lisa Keranen; Jerrold M Olefsky
Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII.
Cellular signalling 2004;16(1):97-104.
2003: Weimin He; Yaacov Barak; Andrea L Hevener; Peter Olson; Debbie Liao; Jamie Le; Michael Nelson; Estelita Ong; Jerrold M Olefsky; Ronald M Evans
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15712-7.
2003: Andrea L Hevener; Weimin He; Yaacov Barak; Jamie Le; Gautam K Bandyopadhyay; Peter Olson; Jason Wilkes; Ronald M Evans; Jerrold M Olefsky
Muscle-specific Pparg deletion causes insulin resistance.
Nature medicine 2003;9(12):1491-7.
2003: Laiping Xie; Seung-Yub Lee; jannik andersen; Steve Waters; Kui Shen; Xiao-Ling Guo; Niels Peter H Moller; Jerrold M Olefsky; David S Lawrence; Zhong-Yin Zhang
Cellular effects of small molecule PTP1B inhibitors on insulin signaling.
Biochemistry 2003;42(44):12792-804.
2003: Jason J Wilkes; Andrea L Hevener; Jerrold M Olefsky
Chronic endothelin-1 treatment leads to insulin resistance in vivo.
Diabetes 2003;52(8):1904-9.
2003: Takeshi Imamura; Jie Huang; Isao Usui; Hiroaki Satoh; Jennie Bever; Jerrold M Olefsky
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.
Molecular and cellular biology 2003;23(14):4892-900.
2003: Joseph G Yu; Sarah M Boies; Jerrold M Olefsky
The effect of oral glucosamine sulfate on insulin sensitivity in human subjects.
Diabetes care 2003;26(6):1941-2.
2003: Isao Usui; Takeshi Imamura; Jie Huang; Hiroaki Satoh; Jerrold M Olefsky
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.
The Journal of biological chemistry 2003;278(16):13765-74.
2003: Bumsup Lee; Philip D Miles; Leonardo Vargas; Peng Luan; Susan Glasco; Yulia Kushnareva; Elisabeth S Kornbrust; Kathryn A Grako; Claes B Wollheim; Pierre Maechler; Jerrold M Olefsky; Christen M Anderson
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.
Diabetes 2003;52(4):965-73.
2003: Philip D G Miles; Yaacov Barak; Ronald M Evans; Jerrold M Olefsky
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E618-26.
2003: Yolanta T Kruszynska; Jerrold M Olefsky; Juan P Frias
Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance.
Metabolism: clinical and experimental 2003;52(2):233-8.
2003: Christopher J Hupfeld; Stéphane Dalle; Jerrold M Olefsky
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):161-6.
2002: Hong Ruan; Philip D G Miles; Christine Ladd; Kenneth Ross; Todd R Golub; Jerrold M Olefsky; Harvey Lodish
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance.
Diabetes 2002;51(11):3176-88.
2002: Joseph G Yu; Sandrine Javorschi; Andrea L Hevener; Yolanta T Kruszynska; Rodney A Norman; Madhur Sinha; Jerrold M Olefsky
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.
Diabetes 2002;51(10):2968-74.
2002: Stéphane Dalle; Takeshi Imamura; David W Rose; Dorothy Sears; Satoshi Ugi; Christopher J Hupfeld; Jerrold M Olefsky
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.
Molecular and cellular biology 2002;22(17):6272-85.
2002: Fujun Liu; Isao Usui; Lui Guojing Evans; Darrell A Austin; Pamela L Mellon; Jerrold M Olefsky; Nicholas J G Webster
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.
The Journal of biological chemistry 2002;277(35):32099-108.
2002: Andrea L Hevener; Donna Reichart; Andrej Janez; Jerrold M Olefsky
Female rats do not exhibit free fatty acid-induced insulin resistance.
Diabetes 2002;51(6):1907-12.
2002: Satoshi Ugi; Prem M Sharma; William Ricketts; Takeshi Imamura; Jerrold M Olefsky
Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes.
The Journal of biological chemistry 2002;277(21):18592-7.
2002: Corinna Herrnstadt; Joanna Elson; Eoin Fahy; Gwen Preston; Douglass M Turnbull; Christen Anderson; Soumitra S Ghosh; Jerrold M Olefsky; M Flint Beal; Robert E Davis; Neil Howell
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.
American journal of human genetics 2002;70(5):1152-71.
2002: Satoshi Ugi; Takeshi Imamura; William Ricketts; Jerrold M Olefsky
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling.
Molecular and cellular biology 2002;22(7):2375-87.
2002: Fujun Liu; Darrell A Austin; Pamela L Mellon; Jerrold M Olefsky; Nicholas J G Webster
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):419-34.
2002: Dorothy Sears; Jerrold M Olefsky
The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):378-89.
2002: Yaacov Barak; Debbie Liao; Weimin He; Estelita S Ong; Michael C Nelson; Jerrold M Olefsky; Richard Boland; Ronald M Evans
Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):303-8.
2002: Yolanta T Kruszynska; Dorothy Sears; Jachelle Ofrecio; Juan P Frias; Gina Macaraeg; Jerrold M Olefsky
Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.
The Journal of clinical endocrinology and metabolism 2002;87(1):226-34.
2001: Takeshi Imamura; Jie Huang; Stéphane Dalle; Satoshi Ugi; Isao Usui; Louis M Luttrell; William E Miller; Robert J Lefkowitz; Jerrold M Olefsky
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
The Journal of biological chemistry 2001;276(47):43663-7.
2001: Dorothy Sears; Jonathan E McDunn; B List; Donna Reichart; Andrea L Hevener; TA Gustafson; C F Barbas; Richard A Lerner; Jerrold M Olefsky
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13514-8.
2001: Jie Huang; Takeshi Imamura; Jerrold M Olefsky
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13084-9.
2001: Jerrold M Olefsky
Nuclear receptor minireview series.
The Journal of biological chemistry 2001;276(40):36863-4.
2001: Andrea L Hevener; Donna Reichart; Andrej Janez; Jerrold M Olefsky
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.
Diabetes 2001;50(10):2316-22.
2001: Juan P Frias; Gina Macaraeg; Jachelle Ofrecio; Joseph G Yu; Jerrold M Olefsky; Yolanta T Kruszynska
Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women.
Diabetes 2001;50(6):1344-50.
2001: Stéphane Dalle; William Ricketts; Takeshi Imamura; P Vollenweider; Jerrold M Olefsky
Insulin and insulin-like growth factor I receptors utilize different G protein signaling components.
The Journal of biological chemistry 2001;276(19):15688-95.
2001: KI Ishibashi; Takeshi Imamura; Prem M Sharma; Jie Huang; Satoshi Ugi; Jerrold M Olefsky
Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes.
The Journal of clinical investigation 2001;107(9):1193-202.
2001: Philip D G Miles; K Higo; Jerrold M Olefsky
Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion.
Diabetes 2001;50(1):139-42.
2000: Andrea L Hevener; Donna Reichart; Jerrold M Olefsky
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
Diabetes 2000;49(12):2154-9.
2000: Andrej Janez; Dorothy Sears; Jerrold M Olefsky
Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes.
Endocrinology 2000;141(12):4657-63.
2000: KI Ishibashi; Takeshi Imamura; Prem M Sharma; Satoshi Ugi; Jerrold M Olefsky
The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes.
Endocrinology 2000;141(12):4623-8.
2000: Andrej Janez; Dorothy Sears; Takeshi Imamura; Prem M Sharma; Jerrold M Olefsky
The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation.
The Journal of biological chemistry 2000;275(35):26870-6.
2000: Jerrold M Olefsky
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.
The Journal of clinical investigation 2000;106(4):467-72.
2000: Katsuya Egawa; N Nakashima; Prem M Sharma; H Maegawa; Y Nagai; A Kashiwagi; R Kikkawa; Jerrold M Olefsky
Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes.
Endocrinology 2000;141(6):1930-5.
2000: N Nakashima; Prem M Sharma; Takeshi Imamura; R Bookstein; Jerrold M Olefsky
The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes.
The Journal of biological chemistry 2000;275(17):12889-95.
2000: Yolanta T Kruszynska; Joseph G Yu; Jerrold M Olefsky; B E Sobel
Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects.
Diabetes 2000;49(4):633-9.
2000: Philip D G Miles; Y Barak; W He; Ronald M Evans; Jerrold M Olefsky
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency.
The Journal of clinical investigation 2000;105(3):287-92.
2000: Juan P Frias; Joseph G Yu; Yolanta T Kruszynska; Jerrold M Olefsky
Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects.
Diabetes care 2000;23(1):64-9.
1999: Joseph G Yu; Yolanta T Kruszynska; MI Mulford; Jerrold M Olefsky
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients.
Diabetes 1999;48(12):2414-21.
1999: Takeshi Imamura; KI Ishibashi; Stéphane Dalle; Satoshi Ugi; Jerrold M Olefsky
Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry 1999;274(47):33691-5.
1999: Takeshi Imamura; P Vollenweider; Katsuya Egawa; M Clodi; KI Ishibashi; N Nakashima; Satoshi Ugi; John W Adams; Joan Heller Brown; Jerrold M Olefsky
G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes.
Molecular and cellular biology 1999;19(10):6765-74.
1999: A Zapf-Colby; Jens Eichhorn; Nicholas J G Webster; Jerrold M Olefsky
Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells.
Oncogene 1999;18(35):4908-19.
1999: Katsuya Egawa; Prem M Sharma; N Nakashima; Yao Huang; E Huver; Gerry R Boss; Jerrold M Olefsky
Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance.
The Journal of biological chemistry 1999;274(20):14306-14.
1999: P Vollenweider; M Clodi; Stuart S Martin; Takeshi Imamura; W M Kavanaugh; Jerrold M Olefsky
An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.
Molecular and cellular biology 1999;19(2):1081-91.
1999: N Nakashima; David W Rose; S Xiao; Katsuya Egawa; Stuart S Martin; T Haruta; Alan Saltiel; Jerrold M Olefsky
The functional role of CrkII in actin cytoskeleton organization and mitogenesis.
The Journal of biological chemistry 1999;274(5):3001-8.
1999: Jerrold M Olefsky
Insulin-stimulated glucose transport minireview series.
The Journal of biological chemistry 1999;274(4):1863.
1998: M Clodi; P Vollenweider; Jes K Klarlund; N Nakashima; Stuart S Martin; Michael P Czech; Jerrold M Olefsky
Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis.
Endocrinology 1998;139(12):4984-90.
1998: P A Staubs; JG Nelson; D R Reichart; Jerrold M Olefsky
Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport.
The Journal of biological chemistry 1998;273(39):25139-47.
1998: Theodore P Ciaraldi; AJ Morales; M G Hickman; R Odom-Ford; Samuel S C Yen; Jerrold M Olefsky
Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome.
Metabolism: clinical and experimental 1998;47(8):940-6.
1998: Prem M Sharma; Katsuya Egawa; Yao Huang; J L Martin; Ivana Huvar; Gerry R Boss; Jerrold M Olefsky
Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action.
The Journal of biological chemistry 1998;273(29):18528-37.
1998: Yolanta T Kruszynska; MI Mulford; J Baloga; Joseph G Yu; Jerrold M Olefsky
Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.
Diabetes 1998;47(7):1107-13.
1998: A Zapf-Colby; Jerrold M Olefsky
Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis.
Endocrinology 1998;139(7):3232-40.
1998: Ayse G Kayali; Jens Eichhorn; T Haruta; Andrew J Morris; JG Nelson; P Vollenweider; Jerrold M Olefsky; Nicholas J G Webster
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.
The Journal of biological chemistry 1998;273(22):13808-18.
1998: Philip D G Miles; K Higo; OM Romeo; M K Lee; K Rafaat; Jerrold M Olefsky
Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.
Diabetes 1998;47(3):395-400.
1998: Philip D G Miles; Song Li; M Hart; OM Romeo; J Cheng; A Cohen; K Raafat; Abdool R Moossa; Jerrold M Olefsky
Mechanisms of insulin resistance in experimental hyperinsulinemic dogs.
The Journal of clinical investigation 1998;101(1):202-11.
1998: T Haruta; Andrew J Morris; P Vollenweider; JG Nelson; David W Rose; M Mueckler; Jerrold M Olefsky
Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation.
Endocrinology 1998;139(1):358-64.
1997: Prem M Sharma; Katsuya Egawa; TA Gustafson; J L Martin; Jerrold M Olefsky
Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes.
Molecular and cellular biology 1997;17(12):7386-97.
1997: Bernhard Ludvik; John J Nolan; A Roberts; J Baloga; M Joyce; J M Bell; Jerrold M Olefsky
Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;100(9):2354-61.
1997: Philip D G Miles; OM Romeo; K Higo; A Cohen; K Rafaat; Jerrold M Olefsky
TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone.
Diabetes 1997;46(11):1678-83.
1997: P Vollenweider; Stuart S Martin; T Haruta; Andrew J Morris; JG Nelson; Mireille Cormont; Yannick Le Marchand-Brustel; David W Rose; Jerrold M Olefsky
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Endocrinology 1997;138(11):4941-9.
1997: Yolanta T Kruszynska; MI Mulford; Joseph G Yu; D A Armstrong; Jerrold M Olefsky
Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion.
Diabetes 1997;46(10):1586-93.
1997: L R Collins; William Ricketts; Jerrold M Olefsky; Joan Heller Brown
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.
Oncogene 1997;15(5):595-600.
1997: Karl Thomaseth; Giovanni Pacini; Martin Clodi; Alexandra Kautzky-Willer; John J Nolan; Rudolf Prager; Jerrold M Olefsky; Bernhard Ludvik
Amylin release during oral glucose tolerance test.
Diabetic medicine : a journal of the British Diabetic Association 1997;14 Suppl 2():S29-34.
1997: John J Nolan; Bernhard Ludvik; J Baloga; Donna Reichart; Jerrold M Olefsky
Mechanisms of the kinetic defect in insulin action in obesity and NIDDM.
Diabetes 1997;46(6):994-1000.
1997: Theodore P Ciaraldi; AJ Morales; M G Hickman; R Odom-Ford; Jerrold M Olefsky; Samuel S C Yen
Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity.
The Journal of clinical endocrinology and metabolism 1997;82(5):1421-5.
1997: Marja Ojaniemi; Stuart S Martin; F Dolfi; Jerrold M Olefsky; Kristiina Vuori
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
The Journal of biological chemistry 1997;272(6):3780-7.
1996: Stuart S Martin; David W Rose; Alan Saltiel; A Klippel; L T Williams; Jerrold M Olefsky
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
Endocrinology 1996;137(11):5045-54.
1996: William Ricketts; David W Rose; S Shoelson; Jerrold M Olefsky
Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling.
The Journal of biological chemistry 1996;271(42):26165-9.
1996: Toshiyasu Sasaoka; Manabu Ishiki; T Sawa; Hajime Ishihara; Yoshimi Takata; T Imamura; Isao Usui; Jerrold M Olefsky; Masashi Kobayashi
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
Endocrinology 1996;137(10):4427-34.
1996: B Lynn Seely; P A Staubs; D R Reichart; Paulos Berhanu; K L Milarski; Alan Saltiel; J Kusari; Jerrold M Olefsky
Protein tyrosine phosphatase 1B interacts with the activated insulin receptor.
Diabetes 1996;45(10):1379-85.
1996: John J Nolan; Jerrold M Olefsky; M R Nyce; RV Considine; JF Caro
Effect of troglitazone on leptin production. Studies in vitro and in human subjects.
Diabetes 1996;45(9):1276-8.
1996: K A Kenner; E Anyanwu; Jerrold M Olefsky; J Kusari
Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling.
The Journal of biological chemistry 1996;271(33):19810-6.
1996: Andrew J Morris; Stuart S Martin; T Haruta; JG Nelson; P Vollenweider; TA Gustafson; M Mueckler; David W Rose; Jerrold M Olefsky
Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8401-6.
1996: Stuart S Martin; T Haruta; Andrew J Morris; A Klippel; L T Williams; Jerrold M Olefsky
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 1996;271(30):17605-8.
1996: JW Kolaczynski; M R Nyce; RV Considine; G Boden; John J Nolan; R Henry; S R Mudaliar; Jerrold M Olefsky; JF Caro
Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro.
Diabetes 1996;45(5):699-701.
1996: Toshiyasu Sasaoka; W J Langlois; F Bai; David W Rose; J Wayne Leitner; S J Decker; Alan Saltiel; G N Gill; Masashi Kobayashi; Boris Draznin; Jerrold M Olefsky
Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites.
The Journal of biological chemistry 1996;271(14):8338-44.
1996: T S Pillay; S Xiao; Jerrold M Olefsky
Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.
The Journal of clinical investigation 1996;97(3):613-20.
1995: T Haruta; Andrew J Morris; David W Rose; JG Nelson; M Mueckler; Jerrold M Olefsky
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway.
The Journal of biological chemistry 1995;270(47):27991-4.
1995: M Khoursheed; Philip D G Miles; K M Gao; M K Lee; A R Moossa; Jerrold M Olefsky
Metabolic effects of troglitazone on fat-induced insulin resistance in the rat.
Metabolism: clinical and experimental 1995;44(11):1489-94.
1995: W J Langlois; Toshiyasu Sasaoka; Alan Saltiel; Jerrold M Olefsky
Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.
The Journal of biological chemistry 1995;270(43):25320-3.
1995: M K Lee; Jerrold M Olefsky
Acute effects of troglitazone on in vivo insulin action in normal rats.
Metabolism: clinical and experimental 1995;44(9):1166-9.
1995: Bernhard Ludvik; John J Nolan; J Baloga; D Sacks; Jerrold M Olefsky
Effect of obesity on insulin resistance in normal subjects and patients with NIDDM.
Diabetes 1995;44(9):1121-5.
1995: B Lynn Seely; D R Reichart; P A Staubs; B H Jhun; D Hsu; H Maegawa; K L Milarski; Alan Saltiel; Jerrold M Olefsky
Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein.
The Journal of biological chemistry 1995;270(32):19151-7.
1995: Philip D G Miles; M Levisetti; D Reichart; M Khoursheed; A R Moossa; Jerrold M Olefsky
Kinetics of insulin action in vivo. Identification of rate-limiting steps.
Diabetes 1995;44(8):947-53.
1995: J Langlois; W Leitner; J Medh; Toshiyasu Sasaoka; Jerrold M Olefsky; Boris Draznin
Mechanism of activation of guanine nucleotide exchange factor by insulin.
Endocrine 1995;3(7):475-9.
1995: B H Jhun; T Haruta; Judy L Meinkoth; W Leitner; Boris Draznin; Alan Saltiel; L Pang; Toshiyasu Sasaoka; Jerrold M Olefsky
Signal transduction pathways leading to insulin-induced early gene induction.
Biochemistry 1995;34(25):7996-8004.
1995: J E Reusch; P Hsieh; P Bhuripanyo; K Carel; J Wayne Leitner; Jerrold M Olefsky; Boris Draznin
Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor.
Endocrinology 1995;136(6):2464-9.
1995: Toshiyasu Sasaoka; W J Langlois; David W Rose; Jerrold M Olefsky
Mechanisms of enhanced transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
The Journal of biological chemistry 1995;270(18):10885-92.
1995: Bernhard Ludvik; John J Nolan; A Roberts; J Baloga; M Joyce; J M Bell; Jerrold M Olefsky
A noninvasive method to measure splanchnic glucose uptake after oral glucose administration.
The Journal of clinical investigation 1995;95(5):2232-8.
1995: W J Langlois; Toshiyasu Sasaoka; C C Yip; Jerrold M Olefsky
Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.
Endocrinology 1995;136(5):1978-86.
1995: Jerrold M Olefsky; John J Nolan
Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms.
The American journal of clinical nutrition 1995;61(4 Suppl):980S-986S.
1995: B Lynn Seely; D R Reichart; Yoshimi Takata; C Yip; Jerrold M Olefsky
A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.
Endocrinology 1995;136(4):1635-41.
1995: T S Pillay; Toshiyasu Sasaoka; Jerrold M Olefsky
Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase.
The Journal of biological chemistry 1995;270(3):991-4.
1995: T S Pillay; W J Langlois; Jerrold M Olefsky
The genetics of non-insulin-dependent diabetes mellitus.
Advances in genetics 1995;32():51-98.
1994: Toshiyasu Sasaoka; W J Langlois; J Wayne Leitner; Boris Draznin; Jerrold M Olefsky
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
The Journal of biological chemistry 1994;269(51):32621-5.
1994: W J Langlois; J Medh; J Wayne Leitner; Toshiyasu Sasaoka; Jerrold M Olefsky; Boris Draznin
Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms.
Endocrinology 1994;135(6):2412-7.
1994: M K Lee; Philip D G Miles; M Khoursheed; K M Gao; A R Moossa; Jerrold M Olefsky
Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.
Diabetes 1994;43(12):1435-9.
1994: P A Staubs; D R Reichart; Alan Saltiel; K L Milarski; H Maegawa; Paulos Berhanu; Jerrold M Olefsky; B Lynn Seely
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.
The Journal of biological chemistry 1994;269(44):27186-92.
1994: John J Nolan; Bernhard Ludvik; P Beerdsen; M Joyce; Jerrold M Olefsky
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
The New England journal of medicine 1994;331(18):1188-93.
1994: B H Jhun; David W Rose; B Lynn Seely; L Rameh; L Cantley; Alan Saltiel; Jerrold M Olefsky
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.
Molecular and cellular biology 1994;14(11):7466-75.
1994: S Xiao; David W Rose; Toshiyasu Sasaoka; H Maegawa; T R Burke; P P Roller; S E Shoelson; Jerrold M Olefsky
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.
The Journal of biological chemistry 1994;269(33):21244-8.
1994: A Zapf; D Hsu; Jerrold M Olefsky
Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts.
Endocrinology 1994;134(6):2445-52.
1994: K A Grako; Donald A McClain; Jerrold M Olefsky
Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 1994;8(6):682-92.
1994: Toshiyasu Sasaoka; David W Rose; B H Jhun; Alan Saltiel; Boris Draznin; Jerrold M Olefsky
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
The Journal of biological chemistry 1994;269(18):13689-94.
1994: Toshiyasu Sasaoka; Boris Draznin; J Wayne Leitner; W J Langlois; Jerrold M Olefsky
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
The Journal of biological chemistry 1994;269(14):10734-8.
1994: B H Jhun; Judy L Meinkoth; J W Leitner; Boris Draznin; Jerrold M Olefsky
Insulin and insulin-like growth factor-I signal transduction requires p21ras.
The Journal of biological chemistry 1994;269(8):5699-704.
1994: D Hsu; P E Knudson; A Zapf; G C Rolband; Jerrold M Olefsky
NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling.
Endocrinology 1994;134(2):744-50.
1994: Theodore P Ciaraldi; M Kettel; A el-Roeiy; Z Madar; D Reichart; Samuel S C Yen; Jerrold M Olefsky
Mechanisms of cellular insulin resistance in human pregnancy.
American journal of obstetrics and gynecology 1994;170(2):635-41.
1994: John J Nolan; G Freidenberg; R Henry; D Reichart; Jerrold M Olefsky
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.
The Journal of clinical endocrinology and metabolism 1994;78(2):471-7.
1994: David W Rose; Alan Saltiel; M Majumdar; S J Decker; Jerrold M Olefsky
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):797-801.
1994: G R Freidenberg; S Suter; Robert R Henry; J Nolan; D Reichart; Jerrold M Olefsky
Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle.
Diabetes 1994;43(1):118-26.
1993: G C Rolband; J F Williams; Nicholas J G Webster; D Hsu; Jerrold M Olefsky
Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling.
Biochemistry 1993;32(49):13545-50.
1993: K A Kenner; David E Hill; Jerrold M Olefsky; J Kusari
Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.
The Journal of biological chemistry 1993;268(34):25455-62.
1993: Boris Draznin; L Chang; J Wayne Leitner; Y Takata; Jerrold M Olefsky
Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.
The Journal of biological chemistry 1993;268(27):19998-20001.
1993: G C Rolband; J F Williams; Nicholas J G Webster; Jerrold M Olefsky
Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling.
Endocrinology 1993;133(3):1437-43.
1993: D Hsu; Jerrold M Olefsky
Effect of a major histocompatibility complex class I peptide on insulin-like growth factor-I receptor internalization and biological signaling.
Endocrinology 1993;133(3):1247-51.
1993: Toshiyasu Sasaoka; Yoshimi Takata; J Kusari; C M Anderson; W J Langlois; Jerrold M Olefsky
Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4379-83.
1993: RM Smith; Toshiyasu Sasaoka; N Shah; Yoshimi Takata; J Kusari; Jerrold M Olefsky; Leonard Jarett
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation.
Endocrinology 1993;132(4):1453-62.
1993: Jerrold M Olefsky
Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: cellular and molecular mechanisms.
Advances in experimental medicine and biology 1993;334():129-50.
1992: D Hsu; Jerrold M Olefsky
Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells.
The Journal of biological chemistry 1992;267(35):25576-82.
1992: R I Fink; P Wallace; G Brechtel; Jerrold M Olefsky
Evidence that glucose transport is rate-limiting for in vivo glucose uptake.
Metabolism: clinical and experimental 1992;41(8):897-902.
1992: Theodore P Ciaraldi; A el-Roeiy; Z Madar; D Reichart; Jerrold M Olefsky; Samuel S C Yen
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism 1992;75(2):577-83.
1992: K A Grako; Jerrold M Olefsky; Donald A McClain
Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors.
Endocrinology 1992;130(6):3441-52.
1992: Yoshimi Takata; Nicholas J G Webster; Jerrold M Olefsky
Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.
The Journal of biological chemistry 1992;267(13):9065-70.
1992: S L Suter; John J Nolan; P Wallace; B Gumbiner; Jerrold M Olefsky
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.
Diabetes care 1992;15(2):193-203.
1991: C M Anderson; Jerrold M Olefsky
Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.
The Journal of biological chemistry 1991;266(32):21760-4.
1991: J Kusari; U S Verma; John B Buse; Robert R Henry; Jerrold M Olefsky
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1991;88(4):1323-30.
1991: RM Smith; B L Seely; N Shah; Jerrold M Olefsky; Leonard Jarett
Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits.
The Journal of biological chemistry 1991;266(26):17522-30.
1991: A A Kassir; A K Upadhyay; T J Lim; A R Moossa; Jerrold M Olefsky
Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies.
Diabetes 1991;40(8):998-1004.
1991: G R Freidenberg; S L Suter; Robert R Henry; D Reichart; Jerrold M Olefsky
In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.
The Journal of clinical investigation 1991;87(6):2222-9.
1991: Yoshimi Takata; Nicholas J G Webster; Jerrold M Olefsky
Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.
The Journal of biological chemistry 1991;266(14):9135-9.
1991: Theodore P Ciaraldi; J M Molina; Jerrold M Olefsky
Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport.
The Journal of clinical endocrinology and metabolism 1991;72(4):876-82.
1991: J Kusari; Yoshimi Takata; E Hatada; G Freidenberg; O Kolterman; Jerrold M Olefsky
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.
The Journal of biological chemistry 1991;266(8):5260-7.
1991: J Kusari; Jerrold M Olefsky; C Strahl; Donald A McClain
Insulin-receptor cDNA sequence in NIDDM patient homozygous for insulin-receptor gene RFLP.
Diabetes 1991;40(2):249-54.
1990: J F Williams; Jerrold M Olefsky
Defective insulin receptor function in down-regulated HepG2 cells.
Endocrinology 1990;127(4):1706-17.
1990: Theodore P Ciaraldi; A Gilmore; Jerrold M Olefsky; M Goldberg; K A Heidenreich
In vitro studies on the action of CS-045, a new antidiabetic agent.
Metabolism: clinical and experimental 1990;39(10):1056-62.
1990: Jerrold M Olefsky
The insulin receptor. A multifunctional protein.
Diabetes 1990;39(9):1009-16.
1990: M Laakso; S V Edelman; Jerrold M Olefsky; G Brechtel; P Wallace; Alain D Baron
Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity.
Diabetes 1990;39(8):965-74.
1990: S V Edelman; M Laakso; P Wallace; G Brechtel; Jerrold M Olefsky; Alain D Baron
Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans.
Diabetes 1990;39(8):955-64.
1990: J F Williams; Donald A McClain; T J Dull; A Ullrich; Jerrold M Olefsky
Characterization of an insulin receptor mutant lacking the subunit processing site.
The Journal of biological chemistry 1990;265(15):8463-9.
1990: J M Molina; G J Cooper; Brendan Leighton; Jerrold M Olefsky
Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide.
Diabetes 1990;39(2):260-5.
1990: J M Molina; Alain D Baron; S V Edelman; G Brechtel; P Wallace; Jerrold M Olefsky
Use of a variable tracer infusion method to determine glucose turnover in humans.
The American journal of physiology 1990;258(1 Pt 1):E16-23.
1989: J M Molina; Theodore P Ciaraldi; D Brady; Jerrold M Olefsky
Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects.
Diabetes 1989;38(8):991-5.
1989: E N Hatada; Donald A McClain; E Potter; A Ullrich; Jerrold M Olefsky
Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells.
The Journal of biological chemistry 1989;264(12):6741-7.
1989: D J Brillon; G R Freidenberg; Robert R Henry; Jerrold M Olefsky
Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations.
Diabetes 1989;38(3):397-403.
1988: Jerrold M Olefsky; W Timothy Garvey; Robert R Henry; D Brillon; Stephan Matthaei; G R Freidenberg
Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes.
The American journal of medicine 1988;85(5A):86-105.
1988: G R Freidenberg; D Reichart; Jerrold M Olefsky; Robert R Henry
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.
The Journal of clinical investigation 1988;82(4):1398-406.
1988: D J Brillon; Robert R Henry; Harald H Klein; Jerrold M Olefsky; G R Freidenberg
Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity.
Endocrinology 1988;123(4):1837-47.
1988: H Maegawa; Jerrold M Olefsky; Scott Thies; D Boyd; A Ullrich; Donald A McClain
Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.
The Journal of biological chemistry 1988;263(25):12629-37.
1988: D A McClain; Robert R Henry; A Ullrich; Jerrold M Olefsky
Restriction-fragment-length polymorphism in insulin-receptor gene and insulin resistance in NIDDM.
Diabetes 1988;37(8):1071-5.
1988: H Maegawa; Donald A McClain; G Freidenberg; Jerrold M Olefsky; M Napier; T Lipari; T J Dull; J Lee; A Ullrich
Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.
The Journal of biological chemistry 1988;263(18):8912-7.
1988: Donald A McClain; H Maegawa; J Levy; T Huecksteadt; T J Dull; J Lee; A Ullrich; Jerrold M Olefsky
Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.
The Journal of biological chemistry 1988;263(18):8904-11.
1988: D A McClain; Jerrold M Olefsky
Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
Diabetes 1988;37(6):806-15.
1988: J R Levy; Jerrold M Olefsky
Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene.
The Journal of biological chemistry 1988;263(13):6101-8.
1988: W Timothy Garvey; T P Huecksteadt; Stephan Matthaei; Jerrold M Olefsky
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1988;81(5):1528-36.
1988: J R Levy; A Ullrich; Jerrold M Olefsky
Endocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene.
The Journal of clinical investigation 1988;81(5):1370-7.
1988: W Timothy Garvey; Jerrold M Olefsky; Arthur H Rubenstein; O G Kolterman
Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion.
Diabetes 1988;37(5):590-9.
1987: J R Levy; Jerrold M Olefsky
The trafficking and processing of insulin and insulin receptors in cultured rat hepatocytes.
Endocrinology 1987;121(6):2075-86.
1987: Donald A McClain; H Maegawa; J Lee; T J Dull; A Ulrich; Jerrold M Olefsky
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
The Journal of biological chemistry 1987;262(30):14663-71.
1987: G R Freidenberg; Robert R Henry; Harald H Klein; D R Reichart; Jerrold M Olefsky
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
The Journal of clinical investigation 1987;79(1):240-50.
1986: Lawrence J. Manderino; Zecharia Madar; O G Kolterman; J M Bell; Jerrold M Olefsky
Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects.
The American journal of physiology 1986;251(4 Pt 1):E489-96.
1985: A D Baron; O G Kolterman; J Bell; Lawrence J. Manderino; Jerrold M Olefsky
Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects.
The Journal of clinical investigation 1985;76(5):1782-8.