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Jerrold Olefsky

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Mice
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Glucose Clamp Technique

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Co-Publications
Name
32
Imamura, Takeshi
14
Rose, David
14
Sasaoka, Toshiyasu
13
Hevener, Andrea
12
Ugi, Satoshi
11
Sharma, Prem
11
Nolan, John
11
Saltiel, Alan
11
Miles, Philip
9
McClain, Donald
9
Huang, Jie
9
Kruszynska, Yolanta
9
Henry, Robert
9
Draznin, Boris
9
Babendure, Jennie

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Publications

TOP 3
Saberi Maziyar; Woods Niels-Bjarne; de Luca Carl; Schenk Simon; Lu Juu Chin; Bandyopadhyay Gautam; Verma Inder M; Olefsky Jerrold M
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.
Patsouris David; Neels Jaap G; Fan WuQiang; Li Ping-Ping; Nguyen M T Audrey; Olefsky Jerrold M
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment.
Olefsky Jerrold M
IKKepsilon: a bridge between obesity and inflammation.

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All Publications

2009: Saberi Maziyar; Woods Niels-Bjarne; de Luca Carl; Schenk Simon; Lu Juu Chin; Bandyopadhyay Gautam; Verma Inder M; Olefsky Jerrold M
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.
Cell metabolism 2009;10(5):419-29.
2009: Patsouris David; Neels Jaap G; Fan WuQiang; Li Ping-Ping; Nguyen M T Audrey; Olefsky Jerrold M
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment.
The Journal of biological chemistry 2009;284(45):31223-35.
2009: Olefsky Jerrold M
IKKepsilon: a bridge between obesity and inflammation.
Cell 2009;138(5):834-6.
2009: Kim Jane J; Li Pingping; Huntley Jessica; Chang Jeffrey P; Arden Karen C; Olefsky Jerrold M
FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.
Diabetes 2009;58(6):1275-82.
2009: Fan Wuqiang; Imamura Takeshi; Sonoda Noriyuki; Sears Dorothy D; Patsouris David; Kim Jane J; Olefsky Jerrold M
FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes.
The Journal of biological chemistry 2009;284(18):12188-97.
2009: Yoshizaki Takeshi; Milne Jill C; Imamura Takeshi; Schenk Simon; Sonoda Noriyuki; Babendure Jennie L; Lu Juu-Chin; Smith Jesse J; Jirousek Michael R; Olefsky Jerrold M
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.
Molecular and cellular biology 2009;29(5):1363-74.
2008: Patsouris David; Li Ping-Ping; Thapar Divya; Chapman Justin; Olefsky Jerrold M; Neels Jaap G
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.
Cell metabolism 2008;8(4):301-9.
2008: Olefsky Jerrold M
Fat talks, liver and muscle listen.
Cell 2008;134(6):914-6.
2008: Schenk Simon; Saberi Maziyar; Olefsky Jerrold M
Insulin sensitivity: modulation by nutrients and inflammation.
The Journal of clinical investigation 2008;118(9):2992-3002.
2008: Féral Chloé C; Neels Jaap G; Kummer Christiane; Slepak Marina; Olefsky Jerrold M; Ginsberg Mark H
Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.
Diabetes 2008;57(7):1842-51.
2008: Sonoda Noriyuki; Imamura Takeshi; Yoshizaki Takeshi; Babendure Jennie L; Lu Juu-Chin; Olefsky Jerrold M
Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6614-9.
2008: Lu Min; Tang Qingbo; Olefsky Jerrold M; Mellon Pamela L; Webster Nicholas J G
Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):760-71.
2008: Yang Xiaoyong; Ongusaha Pat P; Miles Philip D; Havstad Joyce C; Zhang Fengxue; So W Venus; Kudlow Jeffrey E; Michell Robert H; Olefsky Jerrold M; Field Seth J; Evans Ronald M
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Nature 2008;451(7181):964-9.
2008: de Luca Carl; Olefsky Jerrold M
Inflammation and insulin resistance.
FEBS letters 2008;582(1):97-105.
2007: Sears Dorothy D; Hsiao Albert; Ofrecio Jachelle M; Chapman Justin; He Weimin; Olefsky Jerrold M
Selective modulation of promoter recruitment and transcriptional activity of PPARgamma.
Biochemical and biophysical research communications 2007;364(3):515-21.
2007: Milne Jill C; Lambert Philip D; Schenk Simon; Carney David P; Smith Jesse J; Gagne David J; Jin Lei; Boss Olivier; Perni Robert B; Vu Chi B; Bemis Jean E; Xie Roger; Disch Jeremy S; Ng Pui Yee; Nunes Joseph J; Lynch Amy V; Yang Hongying; Galonek Heidi; Israelian Kristine; Choy Wendy; Iffland Andre; Lavu Siva; Medvedik Oliver; Sinclair David A; Olefsky Jerrold M; Jirousek Michael R; Elliott Peter J; Westphal Christoph H
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature 2007;450(7170):712-6.
2007: Solinas Giovanni; Vilcu Cristian; Neels Jaap G; Bandyopadhyay Gautam K; Luo Jun-Li; Naugler Willscott; Grivennikov Sergei; Wynshaw-Boris Anthony; Scadeng Miriam; Olefsky Jerrold M; Karin Michael
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.
Cell metabolism 2007;6(5):386-97.
2007: Nguyen M T Audrey; Favelyukis Svetlana; Nguyen Anh-Khoi; Reichart Donna; Scott Peter A; Jenn Alan; Liu-Bryan Ru; Glass Christopher K; Neels Jaap G; Olefsky Jerrold M
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
The Journal of biological chemistry 2007;282(48):35279-92.
2007: Kawamata Yuji; Imamura Takeshi; Babendure Jennie L; Lu Juu-Chin; Yoshizaki Takeshi; Olefsky Jerrold M
Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex.
The Journal of biological chemistry 2007;282(39):28549-56.
2007: Yoshizaki Takeshi; Imamura Takeshi; Babendure Jennie L; Lu Juu-Chin; Sonoda Noriyuki; Olefsky Jerrold M
Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation.
Molecular and cellular biology 2007;27(14):5172-83.
2007: Liao Wei; Nguyen M T Audrey; Yoshizaki Takeshi; Favelyukis Svetlana; Patsouris David; Imamura Takeshi; Verma Inder M; Olefsky Jerrold M
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E219-27.
2007: Miles Philip D; Treuner Kai; Latronica Marc; Olefsky Jerrold M; Barlow Carrolee
Impaired insulin secretion in a mouse model of ataxia telangiectasia.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E70-4.
2007: Hevener Andrea L; Olefsky Jerrold M; Reichart Donna; Nguyen M T Audrey; Bandyopadyhay Gautam; Leung Ho-Yin; Watt Matthew J; Benner Chris; Febbraio Mark A; Nguyen Anh-Khoi; Folian Brian; Subramaniam Shankar; Gonzalez Frank J; Glass Christopher K; Ricote Mercedes
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
The Journal of clinical investigation 2007;117(6):1658-69.
2007: Lesniewski Lisa A; Hosch Sarah E; Neels Jaap G; de Luca Carl; Pashmforoush Mohammad; Lumeng Carey N; Chiang Shian-Huey; Scadeng Miriam; Saltiel Alan R; Olefsky Jerrold M
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.
Nature medicine 2007;13(4):455-62.
2007: Olefsky Jerrold M
The US's changing competitiveness in the biomedical sciences.
The Journal of clinical investigation 2007;117(1):270-6.
2007: Hupfeld Christopher J; Olefsky Jerrold M
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins.
Annual review of physiology 2007;69():561-77.
2006: Bandyopadhyay Gautam K; Yu Joseph G; Ofrecio Jachelle; Olefsky Jerrold M
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects.
Diabetes 2006;55(8):2277-85.
2006: Hosch Sarah E; Olefsky Jerrold M; Kim Jane J
APPLied mechanics: uncovering how adiponectin modulates insulin action.
Cell metabolism 2006;4(1):5-6.
2006: Neels Jaap G; Olefsky Jerrold M
Cell signaling. A new way to burn fat.
Science (New York, N.Y.) 2006;312(5781):1756-8.
2006: Liao Wei; Nguyen M T Audrey; Imamura Takeshi; Singer Oded; Verma Inder M; Olefsky Jerrold M
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes.
Endocrinology 2006;147(5):2245-52.
2006: Shin Soon Young; Bahk Young Yil; Ko Jesang; Chung Il-Yup; Lee Young Seek; Downward Julian; Eibel Hermann; Sharma Prem M; Olefsky Jerrold M; Kim Young-Ho; Lee Bonghee; Lee Young Han
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.
The EMBO journal 2006;25(5):1093-103.
2006: Lee Chih-Hao; Olson Peter; Hevener Andrea; Mehl Isaac; Chong Ling-Wa; Olefsky Jerrold M; Gonzalez Frank J; Ham Jungyeob; Kang Heonjoong; Peters Jeffrey M; Evans Ronald M
PPARdelta regulates glucose metabolism and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3444-9.
2006: de Luca Carl; Olefsky Jerrold M
Stressed out about obesity and insulin resistance.
Nature medicine 2006;12(1):41-2; discussion 42.
2006: Neels Jaap G; Olefsky Jerrold M
Inflamed fat: what starts the fire?
The Journal of clinical investigation 2006;116(1):33-5.
2005: Huang Jie; Imamura Takeshi; Babendure Jennie L; Lu Juu-Chin; Olefsky Jerrold M
Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(51):42300-6.
2005: Wilkes Jason J; Nguyen M T Audrey; Bandyopadhyay Gautam K; Nelson Elizabeth; Olefsky Jerrold M
Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E1015-22.
2005: Usui Isao; Imamura Takeshi; Babendure Jennie L; Satoh Hiroaki; Lu Juu-Chin; Hupfeld Christopher J; Olefsky Jerrold M
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2005;19(11):2760-8.
2005: Nguyen M T Audrey; Satoh Hiroaki; Favelyukis Svetlana; Babendure Jennie L; Imamura Takeshi; Sbodio Juan I; Zalevsky Jonathan; Dahiyat Bassil I; Chi Nai-Wen; Olefsky Jerrold M
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes.
The Journal of biological chemistry 2005;280(42):35361-71.
2005: Zhang Jin; Hupfeld Christopher J; Taylor Susan S; Olefsky Jerrold M; Tsien Roger Y
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature 2005;437(7058):569-73.
2005: Li Lian-Sheng; Babendure Jennie L; Sinha Subhash C; Olefsky Jerrold M; Lerner Richard A
Synthesis and evaluation of photolabile insulin prodrugs.
Bioorganic & medicinal chemistry letters 2005;15(17):3917-20.
2005: Bandyopadhyay Gautam K; Yu Joseph G; Ofrecio Jachelle; Olefsky Jerold M
Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.
Diabetes 2005;54(8):2351-9.
2005: Hsiao Albert; Ideker Trey; Olefsky Jerrold M; Subramaniam Shankar
VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data.
Nucleic acids research 2005;33(Web Server issue):W627-32.
2005: Satoh Hiroaki; Nguyen M T Audrey; Trujillo Maria; Imamura Takeshi; Usui Isao; Scherer Philipp E; Olefsky Jerrold M
Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats.
Diabetes 2005;54(5):1304-13.
2005: Bard-Chapeau Emilie A; Hevener Andrea L; Long Shinong; Zhang Eric E; Olefsky Jerrold M; Feng Gen-Sheng
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Nature medicine 2005;11(5):567-71.
2005: Goodarzi Mark O; Taylor Kent D; Guo Xiuqing; Quiñones Manuel J; Cui Jinrui; Li Xiaohui; Hang Tieu; Yang Huiying; Holmes Edward; Hsueh Willa A; Olefsky Jerrold; Rotter Jerome I
Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait.
Diabetes 2005;54(4):1222-7.
2005: Wilkes Jason J; Nelson Elizabeth; Osborne Melville; Demarest Keith T; Olefsky Jerrold M
Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats.
American journal of physiology. Endocrinology and metabolism 2005;288(3):E617-24.
2005: Arkan Melek C; Hevener Andrea L; Greten Florian R; Maeda Shin; Li Zhi-Wei; Long Jeffrey M; Wynshaw-Boris Anthony; Poli Giuseppe; Olefsky Jerrold; Karin Michael
IKK-beta links inflammation to obesity-induced insulin resistance.
Nature medicine 2005;11(2):191-8.
2005: Sharma Prem M; Son Hyun-Shik; Ugi Satoshi; Ricketts William; Olefsky Jerrold M
Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):421-30.
2005: Hupfeld Christopher J; Resnik Jamie L; Ugi Satoshi; Olefsky Jerrold M
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors.
The Journal of biological chemistry 2005;280(2):1016-23.
2004: Usui Isao; Imamura Takeshi; Huang Jie; Satoh Hiroaki; Shenoy Sudha K; Lefkowitz Robert J; Hupfeld Christopher J; Olefsky Jerrold M
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
Molecular and cellular biology 2004;24(20):8929-37.
2004: Ugi Satoshi; Imamura Takeshi; Maegawa Hiroshi; Egawa Katsuya; Yoshizaki Takeshi; Shi Kun; Obata Toshiyuki; Ebina Yousuke; Kashiwagi Atsunori; Olefsky Jerrold M
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.
Molecular and cellular biology 2004;24(19):8778-89.
2004: Wiedmer Therese; Zhao Ji; Li Lilin; Zhou Quansheng; Hevener Andrea; Olefsky Jerrold M; Curtiss Linda K; Sims Peter J
Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13296-301.
2004: Satoh Hiroaki; Nguyen M T Audrey; Miles Philip D G; Imamura Takeshi; Usui Isao; Olefsky Jerrold M
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats.
The Journal of clinical investigation 2004;114(2):224-31.
2004: Usui Isao; Imamura Takeshi; Satoh Hiroaki; Huang Jie; Babendure Jennie L; Hupfeld Christopher J; Olefsky Jerrold M
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation.
The EMBO journal 2004;23(14):2821-9.
2004: Koo Seung-Hoi; Satoh Hiroaki; Herzig Stephan; Lee Chih-Hao; Hedrick Susan; Kulkarni Rohit; Evans Ronald M; Olefsky Jerrold; Montminy Marc
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
Nature medicine 2004;10(5):530-4.
2004: Yoshizaki Takeshi; Maegawa Hiroshi; Egawa Katsuya; Ugi Satoshi; Nishio Yoshihiko; Imamura Takeshi; Kobayashi Takayasu; Tamura Shinri; Olefsky Jerrold M; Kashiwagi Atsunori
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(21):22715-26.
2004: Huang Jie; Hsia Stanley H; Imamura Takeshi; Usui Isao; Olefsky Jerrold M
Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes.
Endocrinology 2004;145(4):1579-86.
2004: Pajvani Utpal B; Hawkins Meredith; Combs Terry P; Rajala Michael W; Doebber Tom; Berger Joel P; Wagner John A; Wu Margaret; Knopps Annemie; Xiang Anny H; Utzschneider Kristina M; Kahn Steven E; Olefsky Jerrold M; Buchanan Thomas A; Scherer Philipp E
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.
The Journal of biological chemistry 2004;279(13):12152-62.
2004: Pillay Tahir S; Xiao Sen; Keranen Lisa; Olefsky Jerrold M
Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII.
Cellular signalling 2004;16(1):97-104.
2003: He Weimin; Barak Yaacov; Hevener Andrea; Olson Peter; Liao Debbie; Le Jamie; Nelson Michael; Ong Estelita; Olefsky Jerrold M; Evans Ronald M
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15712-7.
2003: Hevener Andrea L; He Weimin; Barak Yaacov; Le Jamie; Bandyopadhyay Gautam; Olson Peter; Wilkes Jason; Evans Ronald M; Olefsky Jerrold
Muscle-specific Pparg deletion causes insulin resistance.
Nature medicine 2003;9(12):1491-7.
2003: Xie Laiping; Lee Seung-Yub; Andersen Jannik N; Waters Steve; Shen Kui; Guo Xiao-Ling; Moller Niels Peter H; Olefsky Jerrold M; Lawrence David S; Zhang Zhong-Yin
Cellular effects of small molecule PTP1B inhibitors on insulin signaling.
Biochemistry 2003;42(44):12792-804.
2003: Wilkes Jason J; Hevener Andrea; Olefsky Jerrold
Chronic endothelin-1 treatment leads to insulin resistance in vivo.
Diabetes 2003;52(8):1904-9.
2003: Imamura Takeshi; Huang Jie; Usui Isao; Satoh Hiroaki; Bever Jennie; Olefsky Jerrold M
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.
Molecular and cellular biology 2003;23(14):4892-900.
2003: Yu Joseph G; Boies Sarah M; Olefsky Jerrold M
The effect of oral glucosamine sulfate on insulin sensitivity in human subjects.
Diabetes care 2003;26(6):1941-2.
2003: Lee Bumsup; Miles Philip D; Vargas Leonardo; Luan Peng; Glasco Susan; Kushnareva Yulia; Kornbrust Elisabeth S; Grako Kathryn A; Wollheim Claes B; Maechler Pierre; Olefsky Jerrold M; Anderson Christen M
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.
Diabetes 2003;52(4):965-73.
2003: Usui Isao; Imamura Takeshi; Huang Jie; Satoh Hiroaki; Olefsky Jerrold M
Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.
The Journal of biological chemistry 2003;278(16):13765-74.
2003: Miles Philip D G; Barak Yaacov; Evans Ronald M; Olefsky Jerrold M
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E618-26.
2003: Kruszynska Yolanta T; Olefsky Jerrold M; Frias Juan P
Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance.
Metabolism: clinical and experimental 2003;52(2):233-8.
2003: Hupfeld Christopher J; Dalle Stephane; Olefsky Jerrold M
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):161-6.
2002: Ruan Hong; Miles Philip D G; Ladd Christine M; Ross Kenneth; Golub Todd R; Olefsky Jerrold M; Lodish Harvey F
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance.
Diabetes 2002;51(11):3176-88.
2002: Yu Joseph G; Javorschi Sandrine; Hevener Andrea L; Kruszynska Yolanta T; Norman Rodney A; Sinha Madhur; Olefsky Jerrold M
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.
Diabetes 2002;51(10):2968-74.
2002: Dalle Stéphane; Imamura Takeshi; Rose David W; Worrall Dorothy Sears; Ugi Satoshi; Hupfeld Christopher J; Olefsky Jerrold M
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.
Molecular and cellular biology 2002;22(17):6272-85.
2002: Liu Fujun; Usui Isao; Evans Lui Guojing; Austin Darrell A; Mellon Pamela L; Olefsky Jerrold M; Webster Nicholas J G
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.
The Journal of biological chemistry 2002;277(35):32099-108.
2002: Hevener Andrea; Reichart Donna; Janez Andrej; Olefsky Jerrold
Female rats do not exhibit free fatty acid-induced insulin resistance.
Diabetes 2002;51(6):1907-12.
2002: Herrnstadt Corinna; Elson Joanna L; Fahy Eoin; Preston Gwen; Turnbull Douglass M; Anderson Christen; Ghosh Soumitra S; Olefsky Jerrold M; Beal M Flint; Davis Robert E; Howell Neil
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.
American journal of human genetics 2002;70(5):1152-71.
2002: Ugi Satoshi; Sharma Prem M; Ricketts William; Imamura Takeshi; Olefsky Jerrold M
Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes.
The Journal of biological chemistry 2002;277(21):18592-7.
2002: Ugi Satoshi; Imamura Takeshi; Ricketts William; Olefsky Jerrold M
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling.
Molecular and cellular biology 2002;22(7):2375-87.
2002: Liu Fujun; Austin Darrell A; Mellon Pamela L; Olefsky Jerrold M; Webster Nicholas J G
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells.
Molecular endocrinology (Baltimore, Md.) 2002;16(3):419-34.
2002: Worrall Dorothy Sears; Olefsky Jerrold M
The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):378-89.
2002: Kruszynska Yolanta T; Worrall Dorothy Sears; Ofrecio Jachelle; Frias Juan P; Macaraeg Gina; Olefsky Jerrold M
Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation.
The Journal of clinical endocrinology and metabolism 2002;87(1):226-34.
2002: Barak Yaacov; Liao Debbie; He Weimin; Ong Estelita S; Nelson Michael C; Olefsky Jerrold M; Boland Richard; Evans Ronald M
Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):303-8.
2001: Worrall D S; McDunn J E; List B; Reichart D; Hevener A; Gustafson T; Barbas C F; Lerner R A; Olefsky J M
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13514-8.
2001: Huang J; Imamura T; Olefsky J M
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13084-9.
2001: Imamura T; Huang J; Dalle S; Ugi S; Usui I; Luttrell L M; Miller W E; Lefkowitz R J; Olefsky J M
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
The Journal of biological chemistry 2001;276(47):43663-7.
2001: Hevener A L; Reichart D; Janez A; Olefsky J
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.
Diabetes 2001;50(10):2316-22.
2001: Olefsky J M
Nuclear receptor minireview series.
The Journal of biological chemistry 2001;276(40):36863-4.
2001: Frias J P; Macaraeg G B; Ofrecio J; Yu J G; Olefsky J M; Kruszynska Y T
Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women.
Diabetes 2001;50(6):1344-50.
2001: Ishibashi K I; Imamura T; Sharma P M; Huang J; Ugi S; Olefsky J M
Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes.
The Journal of clinical investigation 2001;107(9):1193-202.
2001: Dalle S; Ricketts W; Imamura T; Vollenweider P; Olefsky J M
Insulin and insulin-like growth factor I receptors utilize different G protein signaling components.
The Journal of biological chemistry 2001;276(19):15688-95.
2001: Miles P D; Higo K; Olefsky J M
Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion.
Diabetes 2001;50(1):139-42.
2000: Hevener A L; Reichart D; Olefsky J
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
Diabetes 2000;49(12):2154-9.
2000: Janez A; Worrall D S; Olefsky J M
Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes.
Endocrinology 2000;141(12):4657-63.
2000: Ishibashi K; Imamura T; Sharma P M; Ugi S; Olefsky J M
The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes.
Endocrinology 2000;141(12):4623-8.
2000: Janez A; Worrall D S; Imamura T; Sharma P M; Olefsky J M
The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation.
The Journal of biological chemistry 2000;275(35):26870-6.
2000: Olefsky J M
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.
The Journal of clinical investigation 2000;106(4):467-72.
2000: Egawa K; Nakashima N; Sharma P M; Maegawa H; Nagai Y; Kashiwagi A; Kikkawa R; Olefsky J M
Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes.
Endocrinology 2000;141(6):1930-5.
2000: Kruszynska Y T; Yu J G; Olefsky J M; Sobel B E
Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects.
Diabetes 2000;49(4):633-9.
2000: Nakashima N; Sharma P M; Imamura T; Bookstein R; Olefsky J M
The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes.
The Journal of biological chemistry 2000;275(17):12889-95.
2000: Miles P D; Barak Y; He W; Evans R M; Olefsky J M
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency.
The Journal of clinical investigation 2000;105(3):287-92.
2000: Frias J P; Yu J G; Kruszynska Y T; Olefsky J M
Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects.
Diabetes care 2000;23(1):64-9.
1999: Yu J G; Kruszynska Y T; Mulford M I; Olefsky J M
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients.
Diabetes 1999;48(12):2414-21.
1999: Imamura T; Ishibashi K; Dalle S; Ugi S; Olefsky J M
Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
The Journal of biological chemistry 1999;274(47):33691-5.
1999: Imamura T; Vollenweider P; Egawa K; Clodi M; Ishibashi K; Nakashima N; Ugi S; Adams J W; Brown J H; Olefsky J M
G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes.
Molecular and cellular biology 1999;19(10):6765-74.
1999: Zapf-Colby A; Eichhorn J; Webster N J; Olefsky J M
Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells.
Oncogene 1999;18(35):4908-19.
1999: Egawa K; Sharma P M; Nakashima N; Huang Y; Huver E; Boss G R; Olefsky J M
Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance.
The Journal of biological chemistry 1999;274(20):14306-14.
1999: Vollenweider P; Clodi M; Martin S S; Imamura T; Kavanaugh W M; Olefsky J M
An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.
Molecular and cellular biology 1999;19(2):1081-91.
1999: Nakashima N; Rose D W; Xiao S; Egawa K; Martin S S; Haruta T; Saltiel A R; Olefsky J M
The functional role of CrkII in actin cytoskeleton organization and mitogenesis.
The Journal of biological chemistry 1999;274(5):3001-8.
1999: Olefsky J M
Insulin-stimulated glucose transport minireview series.
The Journal of biological chemistry 1999;274(4):1863.
1998: Clodi M; Vollenweider P; Klarlund J; Nakashima N; Martin S; Czech M P; Olefsky J M
Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis.
Endocrinology 1998;139(12):4984-90.
1998: Staubs P A; Nelson J G; Reichart D R; Olefsky J M
Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport.
The Journal of biological chemistry 1998;273(39):25139-47.
1998: Ciaraldi T P; Morales A J; Hickman M G; Odom-Ford R; Yen S S; Olefsky J M
Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome.
Metabolism: clinical and experimental 1998;47(8):940-6.
1998: Sharma P M; Egawa K; Huang Y; Martin J L; Huvar I; Boss G R; Olefsky J M
Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action.
The Journal of biological chemistry 1998;273(29):18528-37.
1998: Kruszynska Y T; Mulford M I; Baloga J; Yu J G; Olefsky J M
Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.
Diabetes 1998;47(7):1107-13.
1998: Zapf-Colby A; Olefsky J M
Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis.
Endocrinology 1998;139(7):3232-40.
1998: Kayali A G; Eichhorn J; Haruta T; Morris A J; Nelson J G; Vollenweider P; Olefsky J M; Webster N J
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin.
The Journal of biological chemistry 1998;273(22):13808-18.
1998: Miles P D; Higo K; Romeo O M; Lee M K; Rafaat K; Olefsky J M
Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.
Diabetes 1998;47(3):395-400.
1998: Miles P D; Li S; Hart M; Romeo O; Cheng J; Cohen A; Raafat K; Moossa A R; Olefsky J M
Mechanisms of insulin resistance in experimental hyperinsulinemic dogs.
The Journal of clinical investigation 1998;101(1):202-11.
1998: Haruta T; Morris A J; Vollenweider P; Nelson J G; Rose D W; Mueckler M; Olefsky J M
Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation.
Endocrinology 1998;139(1):358-64.
1997: Sharma P M; Egawa K; Gustafson T A; Martin J L; Olefsky J M
Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes.
Molecular and cellular biology 1997;17(12):7386-97.
1997: Ludvik B; Nolan J J; Roberts A; Baloga J; Joyce M; Bell J M; Olefsky J M
Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;100(9):2354-61.
1997: Miles P D; Romeo O M; Higo K; Cohen A; Rafaat K; Olefsky J M
TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone.
Diabetes 1997;46(11):1678-83.
1997: Vollenweider P; Martin S S; Haruta T; Morris A J; Nelson J G; Cormont M; Le Marchand-Brustel Y; Rose D W; Olefsky J M
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Endocrinology 1997;138(11):4941-9.
1997: Kruszynska Y T; Mulford M I; Yu J G; Armstrong D A; Olefsky J M
Effects of nonesterified fatty acids on glucose metabolism after glucose ingestion.
Diabetes 1997;46(10):1586-93.
1997: Collins L R; Ricketts W A; Olefsky J M; Brown J H
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.
Oncogene 1997;15(5):595-600.
1997: Thomaseth K; Pacini G; Clodi M; Kautzky-Willer A; Nolan J J; Prager R; Olefsky J M; Ludvik B
Amylin release during oral glucose tolerance test.
Diabetic medicine : a journal of the British Diabetic Association 1997;14 Suppl 2():S29-34.
1997: Nolan J J; Ludvik B; Baloga J; Reichart D; Olefsky J M
Mechanisms of the kinetic defect in insulin action in obesity and NIDDM.
Diabetes 1997;46(6):994-1000.
1997: Ciaraldi T P; Morales A J; Hickman M G; Odom-Ford R; Olefsky J M; Yen S S
Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity.
The Journal of clinical endocrinology and metabolism 1997;82(5):1421-5.
1997: Ojaniemi M; Martin S S; Dolfi F; Olefsky J M; Vuori K
The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.
The Journal of biological chemistry 1997;272(6):3780-7.
1996: Martin S S; Rose D W; Saltiel A R; Klippel A; Williams L T; Olefsky J M
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown.
Endocrinology 1996;137(11):5045-54.
1996: Sasaoka T; Ishiki M; Sawa T; Ishihara H; Takata Y; Imamura T; Usui I; Olefsky J M; Kobayashi M
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
Endocrinology 1996;137(10):4427-34.
1996: Seely B L; Staubs P A; Reichart D R; Berhanu P; Milarski K L; Saltiel A R; Kusari J; Olefsky J M
Protein tyrosine phosphatase 1B interacts with the activated insulin receptor.
Diabetes 1996;45(10):1379-85.
1996: Ricketts W A; Rose D W; Shoelson S; Olefsky J M
Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling.
The Journal of biological chemistry 1996;271(42):26165-9.
1996: Nolan J J; Olefsky J M; Nyce M R; Considine R V; Caro J F
Effect of troglitazone on leptin production. Studies in vitro and in human subjects.
Diabetes 1996;45(9):1276-8.
1996: Morris A J; Martin S S; Haruta T; Nelson J G; Vollenweider P; Gustafson T A; Mueckler M; Rose D W; Olefsky J M
Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8401-6.
1996: Kenner K A; Anyanwu E; Olefsky J M; Kusari J
Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling.
The Journal of biological chemistry 1996;271(33):19810-6.
1996: Martin S S; Haruta T; Morris A J; Klippel A; Williams L T; Olefsky J M
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes.
The Journal of biological chemistry 1996;271(30):17605-8.
1996: Kolaczynski J W; Nyce M R; Considine R V; Boden G; Nolan J J; Henry R; Mudaliar S R; Olefsky J; Caro J F
Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro.
Diabetes 1996;45(5):699-701.
1996: Sasaoka T; Langlois W J; Bai F; Rose D W; Leitner J W; Decker S J; Saltiel A; Gill G N; Kobayashi M; Draznin B; Olefsky J M
Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites.
The Journal of biological chemistry 1996;271(14):8338-44.
1996: Pillay T S; Xiao S; Olefsky J M
Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.
The Journal of clinical investigation 1996;97(3):613-20.
1995: Haruta T; Morris A J; Rose D W; Nelson J G; Mueckler M; Olefsky J M
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway.
The Journal of biological chemistry 1995;270(47):27991-4.
1995: Khoursheed M; Miles P D; Gao K M; Lee M K; Moossa A R; Olefsky J M
Metabolic effects of troglitazone on fat-induced insulin resistance in the rat.
Metabolism: clinical and experimental 1995;44(11):1489-94.
1995: Langlois W J; Sasaoka T; Saltiel A R; Olefsky J M
Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.
The Journal of biological chemistry 1995;270(43):25320-3.
1995: Lee M K; Olefsky J M
Acute effects of troglitazone on in vivo insulin action in normal rats.
Metabolism: clinical and experimental 1995;44(9):1166-9.
1995: Ludvik B; Nolan J J; Baloga J; Sacks D; Olefsky J
Effect of obesity on insulin resistance in normal subjects and patients with NIDDM.
Diabetes 1995;44(9):1121-5.
1995: Seely B L; Reichart D R; Staubs P A; Jhun B H; Hsu D; Maegawa H; Milarski K L; Saltiel A R; Olefsky J M
Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein.
The Journal of biological chemistry 1995;270(32):19151-7.
1995: Miles P D; Levisetti M; Reichart D; Khoursheed M; Moossa A R; Olefsky J M
Kinetics of insulin action in vivo. Identification of rate-limiting steps.
Diabetes 1995;44(8):947-53.
1995: Reusch J E; Hsieh P; Bhuripanyo P; Carel K; Leitner J W; Olefsky J M; Draznin B
Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor.
Endocrinology 1995;136(6):2464-9.
1995: Jhun B H; Haruta T; Meinkoth J L; Leitner W; Draznin B; Saltiel A R; Pang L; Sasaoka T; Olefsky J M
Signal transduction pathways leading to insulin-induced early gene induction.
Biochemistry 1995;34(25):7996-8004.
1995: Ludvik B; Nolan J J; Roberts A; Baloga J; Joyce M; Bell J M; Olefsky J M
A noninvasive method to measure splanchnic glucose uptake after oral glucose administration.
The Journal of clinical investigation 1995;95(5):2232-8.
1995: Sasaoka T; Langlois W J; Rose D W; Olefsky J M
Mechanisms of enhanced transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
The Journal of biological chemistry 1995;270(18):10885-92.
1995: Langlois W J; Sasaoka T; Yip C C; Olefsky J M
Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.
Endocrinology 1995;136(5):1978-86.
1995: Olefsky J M; Nolan J J
Insulin resistance and non-insulin-dependent diabetes mellitus: cellular and molecular mechanisms.
The American journal of clinical nutrition 1995;61(4 Suppl):980S-986S.
1995: Seely B L; Reichart D R; Takata Y; Yip C; Olefsky J M
A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.
Endocrinology 1995;136(4):1635-41.
1995: Pillay T S; Sasaoka T; Olefsky J M
Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase.
The Journal of biological chemistry 1995;270(3):991-4.
1995: Pillay T S; Langlois W J; Olefsky J M
The genetics of non-insulin-dependent diabetes mellitus.
Advances in genetics 1995;32():51-98.
1994: Langlois W J; Medh J; Leitner J W; Sasaoka T; Olefsky J M; Draznin B
Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms.
Endocrinology 1994;135(6):2412-7.
1994: Lee M K; Miles P D; Khoursheed M; Gao K M; Moossa A R; Olefsky J M
Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.
Diabetes 1994;43(12):1435-9.
1994: Sasaoka T; Langlois W J; Leitner J W; Draznin B; Olefsky J M
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
The Journal of biological chemistry 1994;269(51):32621-5.
1994: Nolan J J; Ludvik B; Beerdsen P; Joyce M; Olefsky J
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
The New England journal of medicine 1994;331(18):1188-93.
1994: Jhun B H; Rose D W; Seely B L; Rameh L; Cantley L; Saltiel A R; Olefsky J M
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.
Molecular and cellular biology 1994;14(11):7466-75.
1994: Staubs P A; Reichart D R; Saltiel A R; Milarski K L; Maegawa H; Berhanu P; Olefsky J M; Seely B L
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.
The Journal of biological chemistry 1994;269(44):27186-92.
1994: Xiao S; Rose D W; Sasaoka T; Maegawa H; Burke T R; Roller P P; Shoelson S E; Olefsky J M
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.
The Journal of biological chemistry 1994;269(33):21244-8.
1994: Zapf A; Hsu D; Olefsky J M
Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts.
Endocrinology 1994;134(6):2445-52.
1994: Grako K A; McClain D A; Olefsky J M
Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 1994;8(6):682-92.
1994: Sasaoka T; Rose D W; Jhun B H; Saltiel A R; Draznin B; Olefsky J M
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
The Journal of biological chemistry 1994;269(18):13689-94.
1994: Sasaoka T; Draznin B; Leitner J W; Langlois W J; Olefsky J M
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
The Journal of biological chemistry 1994;269(14):10734-8.
1994: Hsu D; Knudson P E; Zapf A; Rolband G C; Olefsky J M
NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling.
Endocrinology 1994;134(2):744-50.
1994: Jhun B H; Meinkoth J L; Leitner J W; Draznin B; Olefsky J M
Insulin and insulin-like growth factor-I signal transduction requires p21ras.
The Journal of biological chemistry 1994;269(8):5699-704.
1994: Ciaraldi T P; Kettel M; el-Roeiy A; Madar Z; Reichart D; Yen S S; Olefsky J M
Mechanisms of cellular insulin resistance in human pregnancy.
American journal of obstetrics and gynecology 1994;170(2):635-41.
1994: Nolan J J; Freidenberg G; Henry R; Reichart D; Olefsky J M
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.
The Journal of clinical endocrinology and metabolism 1994;78(2):471-7.
1994: Rose D W; Saltiel A R; Majumdar M; Decker S J; Olefsky J M
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):797-801.
1994: Freidenberg G R; Suter S; Henry R R; Nolan J; Reichart D; Olefsky J M
Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle.
Diabetes 1994;43(1):118-26.
1993: Rolband G C; Williams J F; Webster N J; Hsu D; Olefsky J M
Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling.
Biochemistry 1993;32(49):13545-50.
1993: Kenner K A; Hill D E; Olefsky J M; Kusari J
Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.
The Journal of biological chemistry 1993;268(34):25455-62.
1993: Rolband G C; Williams J F; Webster N J; Olefsky J M
Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling.
Endocrinology 1993;133(3):1437-43.
1993: Draznin B; Chang L; Leitner J W; Takata Y; Olefsky J M
Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors.
The Journal of biological chemistry 1993;268(27):19998-20001.
1993: Hsu D; Olefsky J M
Effect of a major histocompatibility complex class I peptide on insulin-like growth factor-I receptor internalization and biological signaling.
Endocrinology 1993;133(3):1247-51.
1993: Sasaoka T; Takata Y; Kusari J; Anderson C M; Langlois W J; Olefsky J M
Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4379-83.
1993: Smith R M; Sasaoka T; Shah N; Takata Y; Kusari J; Olefsky J M; Jarett L
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation.
Endocrinology 1993;132(4):1453-62.
1993: Olefsky J M
Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: cellular and molecular mechanisms.
Advances in experimental medicine and biology 1993;334():129-50.
1992: Hsu D; Olefsky J M
Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells.
The Journal of biological chemistry 1992;267(35):25576-82.
1992: Fink R I; Wallace P; Brechtel G; Olefsky J M
Evidence that glucose transport is rate-limiting for in vivo glucose uptake.
Metabolism: clinical and experimental 1992;41(8):897-902.
1992: Ciaraldi T P; el-Roeiy A; Madar Z; Reichart D; Olefsky J M; Yen S S
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.
The Journal of clinical endocrinology and metabolism 1992;75(2):577-83.
1992: Grako K A; Olefsky J M; McClain D A
Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors.
Endocrinology 1992;130(6):3441-52.
1992: Takata Y; Webster N J; Olefsky J M
Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.
The Journal of biological chemistry 1992;267(13):9065-70.
1992: Suter S L; Nolan J J; Wallace P; Gumbiner B; Olefsky J M
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects.
Diabetes care 1992;15(2):193-203.
1991: Anderson C M; Olefsky J M
Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.
The Journal of biological chemistry 1991;266(32):21760-4.
1991: Kusari J; Verma U S; Buse J B; Henry R R; Olefsky J M
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1991;88(4):1323-30.
1991: Smith R M; Seely B L; Shah N; Olefsky J M; Jarett L
Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits.
The Journal of biological chemistry 1991;266(26):17522-30.
1991: Kassir A A; Upadhyay A K; Lim T J; Moossa A R; Olefsky J M
Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies.
Diabetes 1991;40(8):998-1004.
1991: Freidenberg G R; Suter S L; Henry R R; Reichart D; Olefsky J M
In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.
The Journal of clinical investigation 1991;87(6):2222-9.
1991: Takata Y; Webster N J; Olefsky J M
Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.
The Journal of biological chemistry 1991;266(14):9135-9.
1991: Ciaraldi T P; Molina J M; Olefsky J M
Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport.
The Journal of clinical endocrinology and metabolism 1991;72(4):876-82.
1991: Kusari J; Takata Y; Hatada E; Freidenberg G; Kolterman O; Olefsky J M
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.
The Journal of biological chemistry 1991;266(8):5260-7.
1991: Kusari J; Olefsky J M; Strahl C; McClain D A
Insulin-receptor cDNA sequence in NIDDM patient homozygous for insulin-receptor gene RFLP.
Diabetes 1991;40(2):249-54.
1990: Williams J F; Olefsky J M
Defective insulin receptor function in down-regulated HepG2 cells.
Endocrinology 1990;127(4):1706-17.
1990: Ciaraldi T P; Gilmore A; Olefsky J M; Goldberg M; Heidenreich K A
In vitro studies on the action of CS-045, a new antidiabetic agent.
Metabolism: clinical and experimental 1990;39(10):1056-62.
1990: Olefsky J M
The insulin receptor. A multifunctional protein.
Diabetes 1990;39(9):1009-16.
1990: Laakso M; Edelman S V; Olefsky J M; Brechtel G; Wallace P; Baron A D
Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity.
Diabetes 1990;39(8):965-74.
1990: Edelman S V; Laakso M; Wallace P; Brechtel G; Olefsky J M; Baron A D
Kinetics of insulin-mediated and non-insulin-mediated glucose uptake in humans.
Diabetes 1990;39(8):955-64.
1990: Williams J F; McClain D A; Dull T J; Ullrich A; Olefsky J M
Characterization of an insulin receptor mutant lacking the subunit processing site.
The Journal of biological chemistry 1990;265(15):8463-9.
1990: Molina J M; Cooper G J; Leighton B; Olefsky J M
Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide.
Diabetes 1990;39(2):260-5.
1990: Molina J M; Baron A D; Edelman S V; Brechtel G; Wallace P; Olefsky J M
Use of a variable tracer infusion method to determine glucose turnover in humans.
The American journal of physiology 1990;258(1 Pt 1):E16-23.
1989: Molina J M; Ciaraldi T P; Brady D; Olefsky J M
Decreased activation rate of insulin-stimulated glucose transport in adipocytes from obese subjects.
Diabetes 1989;38(8):991-5.
1989: Hatada E N; McClain D A; Potter E; Ullrich A; Olefsky J M
Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells.
The Journal of biological chemistry 1989;264(12):6741-7.
1989: Brillon D J; Freidenberg G R; Henry R R; Olefsky J M
Mechanism of defective insulin-receptor kinase activity in NIDDM. Evidence for two receptor populations.
Diabetes 1989;38(3):397-403.
1988: Olefsky J M; Garvey W T; Henry R R; Brillon D; Matthaei S; Freidenberg G R
Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes.
The American journal of medicine 1988;85(5A):86-105.
1988: Freidenberg G R; Reichart D; Olefsky J M; Henry R R
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.
The Journal of clinical investigation 1988;82(4):1398-406.
1988: Brillon D J; Henry R R; Klein H H; Olefsky J M; Freidenberg G R
Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity.
Endocrinology 1988;123(4):1837-47.
1988: Maegawa H; Olefsky J M; Thies S; Boyd D; Ullrich A; McClain D A
Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.
The Journal of biological chemistry 1988;263(25):12629-37.
1988: McClain D A; Henry R R; Ullrich A; Olefsky J M
Restriction-fragment-length polymorphism in insulin-receptor gene and insulin resistance in NIDDM.
Diabetes 1988;37(8):1071-5.
1988: McClain D A; Olefsky J M
Evidence for two independent pathways of insulin-receptor internalization in hepatocytes and hepatoma cells.
Diabetes 1988;37(6):806-15.
1988: Maegawa H; McClain D A; Freidenberg G; Olefsky J M; Napier M; Lipari T; Dull T J; Lee J; Ullrich A
Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.
The Journal of biological chemistry 1988;263(18):8912-7.
1988: McClain D A; Maegawa H; Levy J; Huecksteadt T; Dull T J; Lee J; Ullrich A; Olefsky J M
Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.
The Journal of biological chemistry 1988;263(18):8904-11.
1988: Garvey W T; Huecksteadt T P; Matthaei S; Olefsky J M
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1988;81(5):1528-36.
1988: Levy J R; Ullrich A; Olefsky J M
Endocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene.
The Journal of clinical investigation 1988;81(5):1370-7.
1988: Levy J R; Olefsky J M
Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene.
The Journal of biological chemistry 1988;263(13):6101-8.
1988: Garvey W T; Olefsky J M; Rubenstein A H; Kolterman O G
Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion.
Diabetes 1988;37(5):590-9.
1987: Levy J R; Olefsky J M
The trafficking and processing of insulin and insulin receptors in cultured rat hepatocytes.
Endocrinology 1987;121(6):2075-86.
1987: McClain D A; Maegawa H; Lee J; Dull T J; Ulrich A; Olefsky J M
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.
The Journal of biological chemistry 1987;262(30):14663-71.
1987: Freidenberg G R; Henry R R; Klein H H; Reichart D R; Olefsky J M
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
The Journal of clinical investigation 1987;79(1):240-50.
1986: Mandarino L J; Madar Z; Kolterman O G; Bell J M; Olefsky J M
Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects.
The American journal of physiology 1986;251(4 Pt 1):E489-96.
1985: Baron A D; Kolterman O G; Bell J; Mandarino L J; Olefsky J M
Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects.
The Journal of clinical investigation 1985;76(5):1782-8.

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