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Jack Bennink

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William L Ince; Jack R Bennink; Aissatou Gueye-Mbaye; Jonathan W Yewdell
Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host.
Suman R Das; Mark G Delboy; James S Gibbs; Scott E Hensley; William L Ince; Gustav Russ; Anju Subba; Jack R Bennink; Christopher B Brooke; Jonathan W Yewdell
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.
Christopher B Brooke; William L Ince; Patrick C Wilson; Jens Wrammert; Rafi Ahmed; Jack R Bennink; Jonathan W Yewdell
Most influenza a virions fail to express at least one essential viral protein.

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2013: William L Ince; Jack R Bennink; Aissatou Gueye-Mbaye; Jonathan W Yewdell
Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host.
Journal of virology 2013;87(8):4330-8.
2013: Suman R Das; Mark G Delboy; James S Gibbs; Scott E Hensley; William L Ince; Gustav Russ; Anju Subba; Jack R Bennink; Christopher B Brooke; Jonathan W Yewdell
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.
Cell host & microbe 2013;13(3):314-23.
2013: Christopher B Brooke; William L Ince; Patrick C Wilson; Jens Wrammert; Rafi Ahmed; Jack R Bennink; Jonathan W Yewdell
Most influenza a virions fail to express at least one essential viral protein.
Journal of virology 2013;87(6):3155-62.
2013: Alexandre David; Jack R Bennink; Jonathan W Yewdell
Emetine optimally facilitates nascent chain puromycylation and potentiates the ribopuromycylation method (RPM) applied to inert cells.
Histochemistry and cell biology 2013;139(3):501-4.
2013: Heather D Hickman; Javier G Magadán; Barbara Molon; Barbara F Ngudiankama; Glennys V Reynoso; Erica J Rubin; Jack R Bennink; Vincenzo Bronte; Stephanie S Cush; James Gibbs; Jonathan W Yewdell
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe 2013;13(2):155-68.
2013: Mariana Pavon-Eternod; Jack R Bennink; Peter Berglund; Alexandre David; Kimberly Dittmar; Tao Pan; Jonathan W Yewdell
Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation.
Nucleic acids research 2013;41(3):1914-21.
2012: Xiuju Lu; Jonathan W Yewdell; Jack R Bennink; Alexandre David; Brian P Dolan; James S Gibbs; Heather D Hickman; Yetao Jin; David M Kranz; Rajat Varma
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15407-12.
2012: Brian P Dolan; James S Gibbs; Aditi A Sharma; Jack R Bennink; Tshaka J Cunningham; Jonathan W Yewdell
MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):7025-30.
2012: Alexandre David; Brian P Dolan; Heather D Hickman; Jonathan J Knowlton; Philippe Pierre; Jack R Bennink; Giovanna Clavarino; Jonathan W Yewdell
Nuclear translation visualized by ribosome-bound nascent chain puromycylation.
The Journal of cell biology 2012;197(1):45-57.
2012: Wanqiu Hou; Xiuju Lu; Robert L Modlin; Devika Roy; Jack R Bennink; Christopher B Brooke; James S Gibbs; Jonathan W Yewdell
Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells.
Blood 2012;119(13):3128-31.
2012: Alexandre David; James S Gibbs; Jack R Bennink; Suman Das; Jonathan W Yewdell
Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis.
PloS one 2012;7(3):e33072.
2011: Heather D Hickman; Lily Li; Jacqueline W Mays; Glennys V Reynoso; Erica J Rubin; Owen Schwartz; Cara N Skon; Jack R Bennink; James Gibbs; Jonathan W Yewdell
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine 2011;208(12):2511-24.
2011: Alexandre David; Nir Netzer; Michael Brad Strader; Suman Das; Cai Yun Chen; James Gibbs; Philippe Pierre; Jack R Bennink; Jonathan W Yewdell
RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.
The Journal of biological chemistry 2011;286(23):20688-700.
2011: Brian P Dolan; Jack R Bennink; Jonathan W Yewdell
Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
Cellular and molecular life sciences : CMLS 2011;68(9):1481-9.
2011: Brian P Dolan; Lily Li; Charles A Veltri; Chris M Ireland; Jack R Bennink; Jonathan W Yewdell
Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2065-72.
2011: Scott E Hensley; Suman Das; James S Gibbs; Adam L Bailey; Loren M Schmidt; Jack R Bennink; Jonathan W Yewdell
Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.
PloS one 2011;6(2):e15190.
2011: Heather D Hickman; Jack R Bennink; Jonathan W Yewdell
From optical bench to cageside: intravital microscopy on the long road to rational vaccine design.
Immunological reviews 2011;239(1):209-20.
2010: Brian P Dolan; Jonathan J Knowlton; Alexandre David; Jack R Bennink; Jonathan W Yewdell
RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6728-33.
2010: Scott E Hensley; Damien Zanker; Brian P Dolan; Alexandre David; Heather D Hickman; Alan C Embry; Cara N Skon; Kristie M Grebe; Thomas A Griffin; Weisan Chen; Jack R Bennink; Jonathan W Yewdell
Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4115-22.
2010: Avital Lev; Michael F Princiotta; Damian Zanker; Kazuyo Takeda; James S Gibbs; Chiharu Kumagai; Elizabeth Waffarn; Brian P Dolan; Anne Burgevin; Peter van Endert; Weisan Chen; Jack R Bennink; Jonathan W Yewdell
Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6964-9.
2010: Brian P Dolan; Lily Li; Kazuyo Takeda; Jack R Bennink; Jonathan W Yewdell
Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1419-24.
2010: Kristie M Grebe; Kazuyo Takeda; Heather D Hickman; Adam L Bailey; Adam M Bailey; Alan C Embry; Jack R Bennink; Jonathan W Yewdell
Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):540-4.
2010: Suman Das; Pere Puigbò; Scott E Hensley; Darrell E Hurt; Jack R Bennink; Jonathan W Yewdell
Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.
PLoS pathogens 2010;6(11):e1001211.
2009: Nir Netzer; Jeffrey M Goodenbour; Alexandre David; Kimberly A Dittmar; Richard B Jones; Jeffrey R Schneider; David Boone; Eva M Eves; Marsha R Rosner; James S Gibbs; Alan Embry; Brian Dolan; Suman Das; Heather D Hickman; Peter Berglund; Jack R Bennink; Jonathan W Yewdell; Tao Pan
Innate immune and chemically triggered oxidative stress modifies translational fidelity.
Nature 2009;462(7272):522-6.
2009: Scott E Hensley; Suman Das; Adam L Bailey; Loren M Schmidt; Heather D Hickman; Akila Jayaraman; Karthik Viswanathan; Rahul Raman; Ram Sasisekharan; Jack R Bennink; Jonathan W Yewdell
Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift.
Science (New York, N.Y.) 2009;326(5953):734-6.
2009: Avital Lev; Peniel Dimberu; Suman Das; Jason C Maynard; Christopher V Nicchitta; Jack R Bennink; Jonathan W Yewdell
Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4205-10.
2009: Jeffrey Ishizuka; Kristie Grebe; Eugene Shenderov; Bjoern Peters; Qiongyu Chen; Yanchun Peng; Lili Wang; Tao Dong; Valerie Pasquetto; Carla Oseroff; John Sidney; Heather Hickman; Vincenzo Cerundolo; Alessandro Sette; Jack R Bennink; Andrew McMichael; Jonathan W Yewdell
Quantitating T cell cross-reactivity for unrelated peptide antigens.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4337-45.
2009: Scott E Hensley; Amelia K Pinto; Heather D Hickman; Robin J Kastenmayer; Jack R Bennink; Herbert W Virgin; Jonathan W Yewdell
Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus.
Journal of virology 2009;83(14):7357-60.
2009: Kristie M Grebe; Heather D Hickman; Kari R Irvine; Kazuyo Takeda; Jack R Bennink; jon yewdell
Sympathetic nervous system control of anti-influenza CD8+ T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5300-5.
2009: Heather D Hickman; Jack R Bennink; jon yewdell
Caught in the act: intravital multiphoton microscopy of host-pathogen interactions.
Cell host & microbe 2009;5(1):13-21.
2009: Ingrid Krejnusová; Hana Gocníková; Magdaléna Bystrická; H Blaskovicová; Katarína Poláková; jon yewdell; Jack R Bennink; Gustáv Russ
Antibodies to PB1-F2 protein are induced in response to influenza A virus infection.
Archives of virology 2009;154(10):1599-604.
2008: Kristie M Grebe; jon yewdell; Jack R Bennink
Heterosubtypic immunity to influenza A virus: where do we stand?
Microbes and infection / Institut Pasteur 2008;10(9):1024-9.
2008: S M Mansour Haeryfar; Heather D Hickman; Kari R Irvine; David C Tscharke; Jack R Bennink; jon yewdell
Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):649-59.
2008: Avital Lev; Kazuyo Takeda; Damien Zanker; Jason C Maynard; Peniel Dimberu; Elizabeth Waffarn; James Gibbs; Nir Netzer; Michael F Princiotta; Len Neckers; Didier Picard; Christopher V Nicchitta; Weisan Chen; Yoram Reiter; Jack R Bennink; jon yewdell
The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
Immunity 2008;28(6):787-98.
2008: Heather D Hickman; Kazuyo Takeda; Cara N Skon; Faith R Murray; Scott E Hensley; Joshua Loomis; Glen N Barber; Jack R Bennink; jon yewdell
Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes.
Nature immunology 2008;9(2):155-65.
2007: Julie L McAuley; Felicita Hornung; Kelli L Boyd; Amber M Smith; Raelene McKeon; Jack R Bennink; jon yewdell; Jonathan A McCullers
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia.
Cell host & microbe 2007;2(4):240-9.
2007: Peter Berglund; Diana Finzi; Jack R Bennink; jon yewdell
Viral alteration of cellular translational machinery increases defective ribosomal products.
Journal of virology 2007;81(13):7220-9.
2006: Nathalie Pardigon; Kazuyo Takeda; Bertrand Saunier; Felicita Hornung; James Gibbs; Andrea S Weisberg; Nikhat Contractor; Brian L Kelsall; Jack R Bennink; jon yewdell
CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1590-8.
2006: Shubing Qian; Eric Reits; Jacques Neefjes; Jeanne M Deslich; Jack R Bennink; jon yewdell
Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):227-33.
2006: David C Tscharke; Wai-Ping Woo; Isaac G Sakala; John Sidney; Alessandro Sette; Denis Moss; Jack R Bennink; Gunasegaran Karupiah; jon yewdell
Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice.
Journal of virology 2006;80(13):6318-23.
2006: Shubing Qian; Michael F Princiotta; Jack R Bennink; jon yewdell
Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control.
The Journal of biological chemistry 2006;281(1):392-400.
2005: Valerie Pasquetto; Huynh-Hoa Bui; Rielle Giannino; Cindy Banh; Mirza Fareed; John Sidney; Carla Oseroff; David C Tscharke; Kari Irvine; Jack R Bennink; Bjoern Peters; Scott Southwood; Vincenzo Cerundolo; Howard Grey; jon yewdell; Alessandro Sette
HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5504-15.
2005: Carla Oseroff; FERDYNAND KOS; Huynh-Hoa Bui; Bjoern Peters; Valerie Pasquetto; Jean Glenn; Tara Palmore; John Sidney; David C Tscharke; Jack R Bennink; Scott Southwood; Howard Grey; jon yewdell; Alessandro Sette
HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13980-5.
2005: S M Mansour Haeryfar; Richard DiPaolo; David C Tscharke; Jack R Bennink; jon yewdell
Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3344-51.
2005: David C Tscharke; Gunasegaran Karupiah; Jie Zhou; Tara Palmore; Kari R Irvine; S M Mansour Haeryfar; Shanicka Williams; John Sidney; Alessandro Sette; Jack R Bennink; jon yewdell
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines.
The Journal of experimental medicine 2005;201(1):95-104.
2005: Shubing Qian; Jack R Bennink; jon yewdell
Quantitating defective ribosome products.
Methods in molecular biology (Clifton, N.J.) 2005;301():271-81.
2004: Weisan Chen; Ken Pang; Kelly-Anne Masterman; Gina Kennedy; Sameh Basta; Nektaria Dimopoulos; Felicita Hornung; Mark Smyth; Jack R Bennink; jon yewdell
Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5021-7.
2004: Nathalie Pardigon; Sylvie Darche; Brian L Kelsall; Jack R Bennink; jon yewdell
The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes.
International immunology 2004;16(9):1305-13.
2004: Jack R Bennink
Making the connection: antibody responsiveness and MHC genes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1499.
2004: Christopher C Norbury; Sameh Basta; Keri B Donohue; David C Tscharke; Michael F Princiotta; Peter Berglund; James Gibbs; Jack R Bennink; jon yewdell
CD8+ T cell cross-priming via transfer of proteasome substrates.
Science (New York, N.Y.) 2004;304(5675):1318-21.
2004: Weisan Chen; Kelly-Anne Masterman; Sameh Basta; S M Mansour Haeryfar; Nektaria Dimopoulos; Barbara Knowles; Jack R Bennink; jon yewdell
Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon.
European journal of immunology 2004;34(1):194-9.
2003: James S Gibbs; Daniela Malide; Felicita Hornung; Jack R Bennink; jon yewdell
The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function.
Journal of virology 2003;77(13):7214-24.
2003: Yunjung Cho; Sameh Basta; Weisan Chen; Jack R Bennink; jon yewdell
Heat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus.
Journal of virology 2003;77(8):4679-84.
2003: Michael F Princiotta; Diana Finzi; Shubing Qian; James Gibbs; Sebastian Schuchmann; Frank Buttgereit; Jack R Bennink; jon yewdell
Quantitating protein synthesis, degradation, and endogenous antigen processing.
Immunity 2003;18(3):343-54.
2003: Katarína Poláková; Jack R Bennink; jon yewdell; Magdaléna Bystrická; Elena Bandzuchová; Gustáv Russ
Mild acid treatment induces cross-reactivity of 4H84 monoclonal antibody specific to nonclassical HLA-G antigen with classical HLA class I molecules.
Human immunology 2003;64(2):256-64.
2003: Sameh Basta; Jack R Bennink
A survival game of hide and seek: cytomegaloviruses and MHC class I antigen presentation pathways.
Viral immunology 2003;16(3):231-42.
2002: Shubing Qian; David E Ott; Ulrich Schubert; Jack R Bennink; jon yewdell
Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo.
The Journal of biological chemistry 2002;277(41):38818-26.
2002: Weisan Chen; Jack R Bennink; Phillip A Morton; jon yewdell
Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus.
Journal of virology 2002;76(20):10332-7.
2002: Tonya J Webb; Venkataraman Sriram; Philip M Spence; Ming Gui; Kyoko Hayakawa; Igor Bacik; Jack R Bennink; jon yewdell; Randy R Brutkiewicz
Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5409-14.
2002: Sameh Basta; Weisan Chen; Jack R Bennink; jon yewdell
Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5403-8.
2002: Christopher C Norbury; Daniela Malide; James S Gibbs; Jack R Bennink; jon yewdell
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo.
Nature immunology 2002;3(3):265-71.
2001: Weisan Chen; P A Calvo; Daniela Malide; James Gibbs; Ulrich Schubert; Igor Bacik; Sameh Basta; R O'Neill; Jeanne H Schickli; Peter Palese; P Henklein; Jack R Bennink; jon yewdell
A novel influenza A virus mitochondrial protein that induces cell death.
Nature medicine 2001;7(12):1306-12.
2001: Heiner Wedemeyer; Eishiro Mizukoshi; Anthony R Davis; Jack R Bennink; Barbara Rehermann
Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells.
Journal of virology 2001;75(23):11392-400.
2001: S V Ben-Arieh; B Zimerman; Nechama I Smorodinsky; M Yaacubovicz; Chana Schechter; Igor Bacik; James Gibbs; Jack R Bennink; jon yewdell; John E Coligan; Hueseyin Firat; François Lemonnier; Rachel Ehrlich
Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.
Journal of virology 2001;75(21):10557-62.
2001: Bo Wang; C C Norbury; R Greenwood; Jack R Bennink; jon yewdell; Jeffrey Frelinger
Multiple paths for activation of naive CD8+ T cells: CD4-independent help.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1283-9.
2001: Weisan Chen; Christopher C Norbury; Y Cho; jon yewdell; Jack R Bennink
Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens.
The Journal of experimental medicine 2001;193(11):1319-26.
2001: SA Prasad; Christopher C Norbury; Weisan Chen; Jack R Bennink; jon yewdell
Cutting edge: recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4809-12.
2001: Christopher C Norbury; Michael F Princiotta; Igor Bacik; Randy R Brutkiewicz; P Wood; Tim Elliott; Jack R Bennink; jon yewdell
Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4355-62.
2001: Michael F Princiotta; Ulrich Schubert; Weisan Chen; Jack R Bennink; J Myung; Craig M Crews; jon yewdell
Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):513-8.
2001: Daniela Malide; jon yewdell; Jack R Bennink; Samuel W Cushman
The export of major histocompatibility complex class I molecules from the endoplasmic reticulum of rat brown adipose cells is acutely stimulated by insulin.
Molecular biology of the cell 2001;12(1):101-14.
2001: Weisan Chen; Jack R Bennink; jon yewdell
Quantitating presentation of MHC class I-restricted antigens.
Methods in molecular biology (Clifton, N.J.) 2001;156():245-54.
2001: Luis Anton; Jack R Bennink; jon yewdell
Use of proteasome inhibitors to examine processing of antigens for major histocompatibility complex class I presentation.
Methods in molecular biology (Clifton, N.J.) 2001;156():17-31.
2000: Ulrich Schubert; David E Ott; Elena Chertova; Reinhold Welker; Uwe Tessmer; Michael F Princiotta; Jack R Bennink; H G Krausslich; jon yewdell
Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13057-62.
2000: Jack R Bennink
A novel vaccine approach to stimulate class I restricted T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(6):611-2.
2000: V B Pinto; S Prasad; jon yewdell; Jack R Bennink; Stephen H Hughes
Restricting expression prolongs expression of foreign genes introduced into animals by retroviruses.
Journal of virology 2000;74(21):10202-6.
2000: Ulrich Schubert; Luis Anton; James Gibbs; Christopher C Norbury; jon yewdell; Jack R Bennink
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.
Nature 2000;404(6779):770-4.
2000: Weisan Chen; Luis Anton; Jack R Bennink; jon yewdell
Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.
Immunity 2000;12(1):83-93.
1999: jon yewdell; Luis Anton; Igor Bacik; Ulrich Schubert; HL Snyder; Jack R Bennink
Generating MHC class I ligands from viral gene products.
Immunological reviews 1999;172():97-108.
1999: Luis Anton; Ulrich Schubert; I Bacík; Michael F Princiotta; P A Wearsch; James Gibbs; P M Day; C Realini; Martin Rechsteiner; Jack R Bennink; jon yewdell
Intracellular localization of proteasomal degradation of a viral antigen.
The Journal of cell biology 1999;146(1):113-24.
1999: Weisan Chen; jon yewdell; R L Levine; Jack R Bennink
Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants.
The Journal of experimental medicine 1999;189(11):1757-64.
1999: jon yewdell; C C Norbury; Jack R Bennink
Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines.
Advances in immunology 1999;73():1-77.
1999: jon yewdell; Jack R Bennink
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses.
Annual review of immunology 1999;17():51-88.
1998: G Russ; M Ramachandra; CA Hrycyna; Michael M Gottesman; Ira Pastan; Jack R Bennink; jon yewdell
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer research 1998;58(20):4688-93.
1998: Y Deng; James Gibbs; I Bacík; Angel Porgador; J Copeman; Paul J Lehner; B Ortmann; Peter Cresswell; Jack R Bennink; jon yewdell
Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1677-85.
1998: Domenico Tortorella; Craig Story; J B Huppa; EJ Wiertz; T R Jones; Igor Bacik; Jack R Bennink; jon yewdell; Hidde L Ploegh
Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential.
The Journal of cell biology 1998;142(2):365-76.
1998: Luis Anton; HL Snyder; Jack R Bennink; A Vinitsky; Marian Orlowski; Angel Porgador; jon yewdell
Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4859-68.
1998: HL Snyder; I Bacík; jon yewdell; TW Behrens; Jack R Bennink
Promiscuous liberation of MHC-class I-binding peptides from the C termini of membrane and soluble proteins in the secretory pathway.
European journal of immunology 1998;28(4):1339-46.
1998: Sebastian JOYCE; Amina S Woods; jon yewdell; Jack R Bennink; A Dharshan De Silva; Alina Boesteanu; S P Balk; Robert J Cotter; Randy R Brutkiewicz
Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.
Science (New York, N.Y.) 1998;279(5356):1541-4.
1998: jon yewdell; HL Snyder; Igor Bacik; Luis Anton; Y Deng; TW Behrens; T Bachi; Jack R Bennink
TAP-independent delivery of antigenic peptides to the endoplasmic reticulum: therapeutic potential and insights into TAP-dependent antigen processing.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1998;21(2):127-31.
1998: SA Prasad; jon yewdell; Angel Porgador; B Sadasivan; Peter Cresswell; Jack R Bennink
Calnexin expression does not enhance the generation of MHC class I-peptide complexes.
European journal of immunology 1998;28(3):907-13.
1998: Ulrich Schubert; Luis Anton; I Bacík; J H Cox; Stephan Bour; Jack R Bennink; Marian Orlowski; Klaus Strebel; jon yewdell
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
Journal of virology 1998;72(3):2280-8.
1998: TM Fu; Lawrence M Mylin; Todd D Schell; Igor Bacik; G Russ; jon yewdell; Jack R Bennink; Satvir S Tevethia
An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope.
Journal of virology 1998;72(2):1469-81.
1997: HL Snyder; I Bacík; Jack R Bennink; G Kearns; TW Behrens; T Bächi; Marian Orlowski; jon yewdell
Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing.
The Journal of experimental medicine 1997;186(7):1087-98.
1997: Igor Bacik; HL Snyder; Luis Anton; G Russ; Weisan Chen; Jack R Bennink; L Urge; L Otvos; B Dudkowska; L Eisenlohr; jon yewdell
Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to the cytosol.
The Journal of experimental medicine 1997;186(4):479-87.
1997: P M Day; jon yewdell; Angel Porgador; Ronald N Germain; Jack R Bennink
Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8064-9.
1997: A Vinitsky; Luis Anton; HL Snyder; Marian Orlowski; Jack R Bennink; jon yewdell
The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):554-64.
1997: Angel Porgador; jon yewdell; Y Deng; Jack R Bennink; Ronald N Germain
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody.
Immunity 1997;6(6):715-26.
1997: Thomas Kerkau; Igor Bacik; Jack R Bennink; jon yewdell; T Húnig; Anneliese Schimpl; Ulrich Schubert
The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules.
The Journal of experimental medicine 1997;185(7):1295-305.
1997: Luis Anton; jon yewdell; Jack R Bennink
MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2535-42.
1997: Y Deng; jon yewdell; L C Eisenlohr; Jack R Bennink
MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1507-15.
1996: jon yewdell; Luis Anton; Jack R Bennink
Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1823-6.
1996: Bernard Moss; MW Carroll; Linda S Wyatt; Jack R Bennink; Vanessa M Hirsch; S Goldstein; W R Elkins; Thomas R Fuerst; Jeffrey D Lifson; M Piatak; Nicholas P Restifo; Willem W Overwijk; R Chamberlain; STEVEN ROSENBERG; G Sutter
Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates.
Advances in experimental medicine and biology 1996;397():7-13.
1995: R R Brutkiewicz; Jack R Bennink; jon yewdell; Albert Bendelac
TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1.
The Journal of experimental medicine 1995;182(6):1913-9.
1995: B K Hayes; F Esquivel; Jack R Bennink; jon yewdell; Ajit Varki
Structure of the N-linked oligosaccharides of MHC class I molecules from cells deficient in the antigenic peptide transporter. Implications for the site of peptide association.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3780-7.
1995: G Russ; F Esquivel; jon yewdell; Peter Cresswell; T Spies; Jack R Bennink
Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia viruses.
The Journal of biological chemistry 1995;270(36):21312-8.
1995: Y Deng; Jack R Bennink; H C Kang; Richard P Haugland; jon yewdell
Fluorescent conjugates of brefeldin A selectively stain the endoplasmic reticulum and Golgi complex of living cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(9):907-15.
1995: Albert Bendelac; O Lantz; M E Quimby; jon yewdell; Jack R Bennink; R R Brutkiewicz
CD1 recognition by mouse NK1+ T lymphocytes.
Science (New York, N.Y.) 1995;268(5212):863-5.
1995: Nicholas P Restifo; I Bacík; Kari R Irvine; jon yewdell; B J McCabe; R W Anderson; L C Eisenlohr; STEVEN ROSENBERG; Jack R Bennink
Antigen processing in vivo and the elicitation of primary CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4414-22.
1995: P M Day; F Esquivel; J Lukszo; Jack R Bennink; jon yewdell
Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules.
Immunity 1995;2(2):137-47.
1995: A B Kulkarni; Peter L Collins; Igor Bacik; jon yewdell; Jack R Bennink; James Crowe; Brian Murphy
Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus.
Journal of virology 1995;69(2):1261-4.
1995: J H Cox; P Galardy; Jack R Bennink; jon yewdell
Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):511-9.
1994: HL Snyder; jon yewdell; Jack R Bennink
Trimming of antigenic peptides in an early secretory compartment.
The Journal of experimental medicine 1994;180(6):2389-94.
1994: M Rodrigues; S Li; K Murata; D Rodriguez; J R Rodriguez; Igor Bacik; Jack R Bennink; jon yewdell; A Garcia-Sastre; Ruth S Nussenzweig
Influenza and vaccinia viruses expressing malaria CD8+ T and B cell epitopes. Comparison of their immunogenicity and capacity to induce protective immunity.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4636-48.
1994: J H Cox; R Mark L Buller; Jack R Bennink; jon yewdell; Gunasegaran Karupiah
Expression of adenovirus E3/19K protein does not alter mouse MHC class I-restricted responses to vaccinia virus.
Virology 1994;204(2):558-62.
1994: G Sutter; Linda S Wyatt; P L Foley; Jack R Bennink; Bernard Moss
A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus.
Vaccine 1994;12(11):1032-40.
1994: C M Lawson; Jack R Bennink; Nicholas P Restifo; jon yewdell; Brian Murphy
Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge.
Journal of virology 1994;68(6):3505-11.
1994: jon yewdell; C Lapham; Igor Bacik; T Spies; Jack R Bennink
MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1163-70.
1994: Igor Bacik; J H Cox; R Anderson; jon yewdell; Jack R Bennink
TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):381-7.
1993: Jack R Bennink; R Anderson; Igor Bacik; J Cox; P Day; Y Deng; C Lapham; H Link; G Russ; jon yewdell
Antigen processing: where tumor-specific T-cell responses begin.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(3):202-8.
1993: H Yuwen; J H Cox; jon yewdell; Jack R Bennink; Bernard Moss
Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene.
Virology 1993;195(2):732-44.
1993: Bert O Neil; Y Kawakami; Nicholas P Restifo; Jack R Bennink; jon yewdell; STEVEN ROSENBERG
Detection of shared MHC-restricted human melanoma antigens after vaccinia virus-mediated transduction of genes coding for HLA.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1410-8.
1993: A B Kulkarni; Herbert C Morse; Jack R Bennink; jon yewdell; Brian Murphy
Immunization of mice with vaccinia virus-M2 recombinant induces epitope-specific and cross-reactive Kd-restricted CD8+ cytotoxic T cells.
Journal of virology 1993;67(7):4086-92.
1993: jon yewdell; F Esquivel; D Arnold; T Spies; Laurence C Eisenlohr; Jack R Bennink
Presentation of numerous viral peptides to mouse major histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse-human transporter.
The Journal of experimental medicine 1993;177(6):1785-90.
1993: C K Lapham; I Bacík; jon yewdell; K P Kane; Jack R Bennink
Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.
The Journal of experimental medicine 1993;177(6):1633-41.
1993: Nicholas P Restifo; F Esquivel; Y Kawakami; jon yewdell; James J Mulé; STEVEN ROSENBERG; Jack R Bennink
Identification of human cancers deficient in antigen processing.
The Journal of experimental medicine 1993;177(2):265-72.
1992: Laurence C Eisenlohr; Igor Bacik; Jack R Bennink; K Bernstein; jon yewdell
Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes.
Cell 1992;71(6):963-72.
1992: Laurence C Eisenlohr; jon yewdell; Jack R Bennink
A transient transfection system for identifying biosynthesized proteins processed and presented to class I MHC restricted T lymphocytes.
Journal of immunological methods 1992;154(1):131-8.
1992: Laurence C Eisenlohr; jon yewdell; Jack R Bennink
Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.
The Journal of experimental medicine 1992;175(2):481-7.
1992: jon yewdell; Jack R Bennink
Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes.
Advances in immunology 1992;52():1-123.
1992: F Esquivel; jon yewdell; Jack R Bennink
RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.
The Journal of experimental medicine 1992;175(1):163-8.
1991: J H Cox; Jack R Bennink; jon yewdell
Retention of adenovirus E19 glycoprotein in the endoplasmic reticulum is essential to its ability to block antigen presentation.
The Journal of experimental medicine 1991;174(6):1629-37.
1991: Nicholas P Restifo; F Esquivel; A L Asher; H Stötter; R J Barth; Jack R Bennink; James J Mulé; jon yewdell; STEVEN ROSENBERG
Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1453-9.
1991: G Russ; Jack R Bennink; T Bächi; jon yewdell
Influenza virus hemagglutinin trimers and monomers maintain distinct biochemical modifications and intracellular distribution in brefeldin A-treated cells.
Cell regulation 1991;2(7):549-63.
1990: jon yewdell; Jack R Bennink
The binary logic of antigen processing and presentation to T cells.
Cell 1990;62(2):203-6.
1990: J H Cox; jon yewdell; Laurence C Eisenlohr; P R Johnson; Jack R Bennink
Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum.
Science (New York, N.Y.) 1990;247(4943):715-8.
1989: jon yewdell; Laurence C Eisenlohr; J H Cox; G Russ; Jack R Bennink
Processing and presentation of antigens to class I restricted T lymphocytes.
The Year in immunology 1989;6():38-50.
1988: Jack R Bennink; jon yewdell
Murine cytotoxic T lymphocyte recognition of individual influenza virus proteins. High frequency of nonresponder MHC class I alleles.
The Journal of experimental medicine 1988;168(5):1935-9.