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Vesa Olkkonen

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Shan-yu Qin; You Zhou; Bang-li Hu; Hai-Xing Jiang; Jie Liu; Vesa M Olkkonen
Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies.
S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Terhi Vihervaara; Reijo Kakela; Gerhard Liebisch; Gerd Schmitz; Kirill Tarasov; Vesa M Olkkonen
Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins.

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2013: Shan-yu Qin; You Zhou; Bang-li Hu; Hai-Xing Jiang; Jie Liu; Vesa M Olkkonen
Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies.
Atherosclerosis 2013;227(2):360-6.
2013: S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Diabetologia 2013;56(4):886-92.
2013: Terhi Vihervaara; Reijo Kakela; Gerhard Liebisch; Gerd Schmitz; Kirill Tarasov; Vesa M Olkkonen
Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins.
Biochimie 2013;95(3):538-47.
2013: Fei Li; Vesa M Olkkonen; Yue-Jun Du; Li-Na Hou; Rui-Ting Hu; Xin-Ji Zhang; You Zhou; Wan-Long Tan
Egg consumption and risk of bladder cancer: a meta-analysis.
Nutrition and cancer 2013;65(4):538-46.
2013: Olivier Béaslas; Helena Gylling; Matti Jauhiainen; Essi Kaiharju; Leena Kaipiainen; Pirkka-Pekka Laurila; Mikko I Mäyränpää; Jari Metso; Eija Nissilä; Krishna Chaithanya Batchu; Daoguang Yan; Vesa M Olkkonen
Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
PloS one 2013;8(3):e58856.
2013: Arjan Boerke; Jos F H M Brouwers; J Bernd Helms; Vesa M Olkkonen; Eric J Schoevers; Edita Sostaric; Chris H A van de Lest; Bart M Gadella
Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization.
Biology of reproduction 2013;88(1):21.
2012: Fei Li; Vesa M Olkkonen; Pei Wan; You Zhou; Yong-tong Zhu; Ding-nan Chen; San-san Chen; Wei Chen; Cheng-wu He; Nan He; Kai-jian Lan; Wan-long Tan
Identification of urinary Gc-globulin as a novel biomarker for bladder cancer by two-dimensional fluorescent differential gel electrophoresis (2D-DIGE).
Journal of proteomics 2012;77():225-36.
2012: Eija Nissilä; Yuki Ohsaki; Julia Perttilä; Marion Weber-Boyvat; Elina Ikonen; Vesa M Olkkonen
ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.
Biochimica et biophysica acta 2012;1821(12):1472-84.
2012: Ksenia Sevastianova; Kaisa Silander; Barbara A Fielding; Helena Gylling; Antti Hakkarainen; Anna Kotronen; Jesper Lundbom; Nina Lundbom; Janne Makkonen; Vesa M Olkkonen; Markku Peltonen; Aila Rissanen; Stefano Romeo; Alexandre Santos; Hannele Yki-Järvinen
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.
The American journal of clinical nutrition 2012;96(4):727-34.
2012: Vesa M Olkkonen
Macrophage oxysterols and their binding proteins: roles in atherosclerosis.
Current opinion in lipidology 2012;23(5):462-70.
2012: Kyubo Kim; James A McNew; Rupesh Nigam; Vesa M Olkkonen; Youlia M Petrova; Lucia Piccotti; Binhui Ren; Elsa M Rodarte; Brenton L Scott; Michael J Tuvim; Joo-Heon Yoon; Roberto Adachi; Anurag Agrawal; Zoulikha Azzegagh; Rustam Bagirzadeh; Christopher M Evans; Alejandra Gomez; Burton F Dickey
Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells.
The Biochemical journal 2012;446(3):383-94.
2012: Olivier Béaslas; Pirkka-Pekka Laurila; Jiwei Li; Terhi Vihervaara; Daoguang Yan; Vesa M Olkkonen
Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity.
Experimental cell research 2012;318(15):1933-45.
2012: Kristiina Uusi-Rauva; Rik van der Kant; Jouni Vesa; Aija Kyttälä; Jacques Neefjes; Vesa M Olkkonen; Kimmo Tanhuanpää; Anu Jalanko
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.
Cellular and molecular life sciences : CMLS 2012;69(12):2075-89.
2012: Julia Perttilä; Bart Staels; Kimmo Tanhuanpää; Hannele Yki-Järvinen; Sandrine Caron; Carolina Huaman-Samanez; Vesa M Olkkonen
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis.
American journal of physiology. Endocrinology and metabolism 2012;302(9):E1063-9.
2012: Hai Thi Do; Tho Huu Ho; Laura Korhonen; Johanna Mäkelä; Vesa M Olkkonen; Timofey V Tselykh; Noam Zelcer; Beat Bornhauser; Dan Lindholm
Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).
The Journal of biological chemistry 2012;287(16):12602-11.
2012: Marius R Robciuc; Paulina Skrobuk; Matti Jauhiainen; Heikki A Koistinen; Vesa M Olkkonen; Kari Alitalo; Andrey Anisimov; Robert H Eckel; Christian Ehnholm
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
PloS one 2012;7(10):e46212.
2012: You Zhou; Marius R Robciuc; Martin Wabitsch; Hannele Yki-Järvinen; Christian Ehnholm; Anne Juuti; Marja Leivonen; Vesa M Olkkonen
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.
PloS one 2012;7(9):e45352.
2012: Jarkko Soronen; Ida Surakka; Matti Jauhiainen; Pirkka-Pekka Laurila; Jussi Naukkarinen; Vesa M Olkkonen; Samuli Ripatti; Hannele Yki-Järvinen
Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects.
BMC medical genomics 2012;5():9.
2011: Wenbin Zhong; Tianhong Zhou; You Zhou; Hongye Li; Shiqian Li; Hongling Ma; Vesa M Olkkonen; Kunde Wei; Daoguang Yan
OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.
Experimental cell research 2011;317(16):2353-63.
2011: Terhi Vihervaara; Riikka-Liisa Uronen; Elina Ikonen; Maurice Jansen; Yuki Ohsaki; Vesa M Olkkonen
Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?
Chemistry and physics of lipids 2011;164(6):443-50.
2011: Ksenia Sevastianova; Meline Sievers; Jussi Sutinen; Dick Wågsäter; Ulrich A Walker; Petri Auvinen; Sven Enerbäck; Per Eriksson; Dario Greco; Martin E Lidell; Vesa M Olkkonen; Julia Perttilä; Matti Ristola; Kaisa Salmenkivi; Hannele Yki-Järvinen
Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy.
Diabetes 2011;60(7):1894-900.
2011: Ksenia Sevastianova; Laura Suojanen; Eleuterio Ferrannini; Amalia Gastaldelli; Antti Hakkarainen; Anna Kotronen; Jesper Lundbom; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; Julia Perttilä; Aila Rissanen; Hannele Yki-Järvinen
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
The American journal of clinical nutrition 2011;94(1):104-11.
2011: Sabine D Jordan; Markus Krüger; Diana M Willmes; Nora Redemann; F Thomas Wunderlich; Hella S Brönneke; Carsten Merkwirth; Hamid Kashkar; Vesa M Olkkonen; Thomas Böttger; Thomas Braun; Jost Seibler; Jens C Brüning
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
Nature cell biology 2011;13(4):434-46.
2011: Maurice Jansen; Yuki Ohsaki; Laura Rita Rega; Robert Bittman; Vesa M Olkkonen; Elina Ikonen
Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.
Traffic (Copenhagen, Denmark) 2011;12(2):218-31.
2011: Terhi Vihervaara; Riikka-Liisa Uronen; Gerd Wohlfahrt; Ingemar Björkhem; Elina Ikonen; Vesa M Olkkonen
Sterol binding by OSBP-related protein 1L regulates late endosome motility and function.
Cellular and molecular life sciences : CMLS 2011;68(3):537-51.
2011: Tianhong Zhou; Wenbin Zhong; Olivier Béaslas; Yingliang Jiang; Markku Lehto; Shiqian Li; Wei Luo; Vesa M Olkkonen; Julia Perttilä; Terhi Vihervaara; Daoguang Yan
OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.
PloS one 2011;6(6):e21078.
2010: Jukka Westerbacka; Anna Kotronen; Barbara A Fielding; John Wahren; Leanne Hodson; Julia Perttilä; Tuulikki Seppänen-Laakso; Tapani Suortti; Johanna Arola; Rolf Hultcrantz; Sandra Castillo; Vesa M Olkkonen; Keith N Frayn; Matej Orešič; Hannele Yki-Järvinen
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Gastroenterology 2010;139(6):1961-1971.e1.
2010: You Zhou; Shiqian Li; Mikko I Mäyränpää; Wenbin Zhong; Nils Bäck; Daoguang Yan; Vesa M Olkkonen
OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface.
Experimental cell research 2010;316(19):3304-16.
2009: Julia Perttilä; Krista Merikanto; Jussi Naukkarinen; Ida Surakka; Nicolas W Martin; Kimmo Tanhuanpää; Vinciane Grimard; Marja-Riitta Taskinen; Christoph Thiele; Veikko Salomaa; Antti Jula; Markus Perola; Ismo Virtanen; Leena Peltonen; Vesa M Olkkonen
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.
Journal of molecular medicine (Berlin, Germany) 2009;87(8):825-35.
2009: Yi Zhang; You-Hou Kang; Nathan Chang; Patrick P L Lam; Yunfeng Liu; Vesa M Olkkonen; Herbert Y Gaisano
Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.
The Journal of biological chemistry 2009;284(31):20840-7.
2009: Sonia Paco; Maria A Margelí; Vesa M Olkkonen; Akane Imai; Juan Blasi; Reiner Fischer-Colbrie; Fernando Aguado
Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes.
Journal of neurochemistry 2009;110(1):143-56.
2009: Riikka Hynynen; Monika Suchanek; Johanna Spandl; Nils Bäck; Christoph Thiele; Vesa M Olkkonen
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.
Journal of lipid research 2009;50(7):1305-15.
2009: Matts D Linder; Mikko I Mäyränpää; Johan Peränen; Taija E Pietilä; Vilja M Pietiäinen; Riikka-Liisa Uronen; Vesa M Olkkonen; Petri T Kovanen; Elina Ikonen
Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):883-8.
2009: Vesa M Olkkonen; Riikka Hynynen
Interactions of oxysterols with membranes and proteins.
Molecular aspects of medicine 2009;30(3):123-33.
2009: Hiroaki Suzuki; Kohsuke Kanekura; Timothy P Levine; Kenji Kohno; Vesa M Olkkonen; Sadakazu Aiso; Masaaki Matsuoka
ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.
Journal of neurochemistry 2009;108(4):973-985.
2008: Markku Lehto; Mikko I Mäyränpää; Teijo Pellinen; Pekka Ihalmo; Sanna Lehtonen; Petri T Kovanen; Per-Henrik Groop; Johanna Ivaska; Vesa M Olkkonen
The R-Ras interaction partner ORP3 regulates cell adhesion.
Journal of cell science 2008;121(Pt 5):695-705.
2008: Daoguang Yan; Mikko I Mäyränpää; Jenny Wong; Julia Perttilä; Markku Lehto; Matti Jauhiainen; Petri T Kovanen; Christian Ehnholm; Andrew J Brown; Vesa M Olkkonen
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
The Journal of biological chemistry 2008;283(1):332-40.
2008: Daoguang Yan; Vesa M Olkkonen
Characteristics of oxysterol binding proteins.
International review of cytology 2008;265():253-85.
2007: Riikka Vikstedt; Jari Metso; Jukka Hakala; Vesa M Olkkonen; Christian Ehnholm; Matti Jauhiainen
Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.
Biochemistry 2007;46(42):11979-86.
2007: Monika Suchanek; Riikka Hynynen; Gerd Wohlfahrt; Markku Lehto; Marie Johansson; Hannu Saarinen; Anna Radzikowska; Christoph Thiele; Vesa M Olkkonen
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
The Biochemical journal 2007;405(3):473-80.
2007: Daoguang Yan; Matti Jauhiainen; Reeni B Hildebrand; Ko Willems van Dijk; Theo Van berkel; Christian Ehnholm; Miranda van Eck; Vesa M Olkkonen
Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1618-24.
2007: Patrick P L Lam; Kati Hyvärinen; Maria Kauppi; Laura I Cosen-Binker; Saara Laitinen; Sirkka Keränen; Herbert Y Gaisano; Vesa M Olkkonen
A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.
Molecular biology of the cell 2007;18(7):2473-80.
2007: Igor Bykov; Matti Jauhiainen; Vesa M Olkkonen; Sirkku Saarikoski; Christian Ehnholm; Sami Junnikkala; Antti Väkevä; Kai O Lindros; Seppo Meri
Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis.
Journal of hepatology 2007;46(5):907-14.
2007: Daoguang Yan; Markku Lehto; Laura Rasilainen; Jari Metso; Christian Ehnholm; Seppo Ylä-Herttuala; Matti Jauhiainen; Vesa M Olkkonen
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1108-14.
2007: Marie Johansson; Nuno Rocha; Wilbert Zwart; Ingrid Jordens; Lennert Janssen; Coenraad Kuijl; Vesa M Olkkonen; Jacques Neefjes
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin.
The Journal of cell biology 2007;176(4):459-71.
2007: Sarah Siggins; Igor Bykov; Martin Hermansson; Pentti Somerharju; Kai Lindros; Tatu A Miettinen; Matti Jauhiainen; Vesa M Olkkonen; Christian Ehnholm
Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.
Atherosclerosis 2007;190(1):114-23.
2006: Vesa M Olkkonen; Elina Ikonen
When intracellular logistics fails--genetic defects in membrane trafficking.
Journal of cell science 2006;119(Pt 24):5031-45.
2006: Vesa M Olkkonen; Marie Johansson; Monika Suchanek; Daoguang Yan; Riikka Hynynen; Christian Ehnholm; Matti Jauhiainen; Christoph Thiele; Markku Lehto
The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?
Biochemical Society transactions 2006;34(Pt 3):389-91.
2006: Sarah Siggins; Christian Ehnholm; Matti Jauhiainen; Vesa M Olkkonen
Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(2):117-25.
2005: Marie Johansson; Markku Lehto; Kimmo Tanhuanpää; Timothy L Cover; Vesa M Olkkonen
The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.
Molecular biology of the cell 2005;16(12):5480-92.
2005: Markku Lehto; Riikka Hynynen; Katja Karjalainen; Esa Kuismanen; Kati Hyvärinen; Vesa M Olkkonen
Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.
Experimental cell research 2005;310(2):445-62.
2005: Reijo Kakela; Kimmo Tanhuanpää; Saara Laitinen; Pentti Somerharju; Vesa M Olkkonen
Overexpression of OSBP-related protein 2 (ORP2) in CHO cells induces alterations of phospholipid species composition.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2005;83(5):677-83.
2005: Riikka Hynynen; Saara Laitinen; Reijo Kakela; Kimmo Tanhuanpää; Sari Lusa / Löytökorpi; Christian Ehnholm; Pentti Somerharju; Elina Ikonen; Vesa M Olkkonen
Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis.
The Biochemical journal 2005;390(Pt 1):273-83.
2005: Minna T Jänis; Jari Metso; Hilkka Lankinen; Tomas Strandin; Vesa M Olkkonen; Kerry-Anne Rye; Matti Jauhiainen; Christian Ehnholm
Apolipoprotein E activates the low-activity form of human phospholipid transfer protein.
Biochemical and biophysical research communications 2005;331(1):333-40.
2005: Marie Johansson; Vesa M Olkkonen
Assays for interaction between Rab7 and oxysterol binding protein related protein 1L (ORP1L).
Methods in enzymology 2005;403():743-58.
2004: Minna T Jänis; Sarah Siggins; Esa Tahvanainen; Riikka Vikstedt; Kaisa Silander; Jari Metso; Arpo Aromaa; Marja-Riitta Taskinen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample.
Journal of lipid research 2004;45(12):2303-9.
2004: Vesa M Olkkonen
Oxysterol binding protein and its homologues: new regulatory factors involved in lipid metabolism.
Current opinion in lipidology 2004;15(3):321-7.
2004: Vesa M Olkkonen; Timothy P Levine
Oxysterol binding proteins: in more than one place at one time?
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(1):87-98.
2004: Sarah Siggins; Minna Kärkkäinen; Jukka Tenhunen; Jari Metso; Esa Tahvanainen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA.
Journal of lipid research 2004;45(2):387-95.
2004: Vesa M Olkkonen; Markku Lehto
Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis.
Annals of medicine 2004;36(8):562-72.
2004: Markku Lehto; Jukka Tienari; Sanna Lehtonen; Eero Lehtonen; Vesa M Olkkonen
Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.
Cell and tissue research 2004;315(1):39-57.
2003: Sarah Siggins; Matti Jauhiainen; Vesa M Olkkonen; Jukka Tenhunen; Christian Ehnholm
PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma.
Journal of lipid research 2003;44(9):1698-704.
2003: Marie Johansson; Virginie Bocher; Markku Lehto; Giulia Chinetti; Esa Kuismanen; Christian Ehnholm; Bart Staels; Vesa M Olkkonen
The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.
Molecular biology of the cell 2003;14(3):903-15.
2003: Markku Lehto; Vesa M Olkkonen
The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling.
Biochimica et biophysica acta 2003;1631(1):1-11.
2003: Noora Kaivo-oja; Jonas Bondestam; Meerit Kämäräinen; Janne Koskimies; Ursula Vitt; Mark Cranfield; Kaisa Vuojolainen; Janne P Kallio; Vesa M Olkkonen; Masaru Hayashi; Aristidis Moustakas; nigel P groome; Peter ten Dijke; Aaron J W Hsueh; Olli Ritvos
Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells.
The Journal of clinical endocrinology and metabolism 2003;88(2):755-62.
2002: Arja M Band; Heidi Ali; Maria K Vartiainen; Saara Welti; Pekka Lappalainen; Vesa M Olkkonen; Esa Kuismanen
Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton.
FEBS letters 2002;531(3):513-9.
2002: Maria Kauppi; Gerd Wohlfahrt; Vesa M Olkkonen
Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.
The Journal of biological chemistry 2002;277(46):43973-9.
2002: Minna Kärkkäinen; Tomoichiro Oka; Vesa M Olkkonen; Jari Metso; Hiroaki Hattori; Matti Jauhiainen; Christian Ehnholm
Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).
The Journal of biological chemistry 2002;277(18):15413-8.
2002: Maria Kauppi; Anne Simonsen; Bjørn Bremnes; Amandio Vieira; judy callaghan; Harald Stenmark; Vesa M Olkkonen
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking.
Journal of cell science 2002;115(Pt 5):899-911.
2002: Saara Laitinen; Markku Lehto; Sanna Lehtonen; Kati Hyvärinen; Sanna Heino; Eero Lehtonen; Christian Ehnholm; Elina Ikonen; Vesa M Olkkonen
ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.
Journal of lipid research 2002;43(2):245-55.
2001: Markku Lehto; Saara Laitinen; Giulia Chinetti; Marie Johansson; Christian Ehnholm; Bart Staels; Elina Ikonen; Vesa M Olkkonen
The OSBP-related protein family in humans.
Journal of lipid research 2001;42(8):1203-13.
2001: Sonja Jaari; Ko Willems van Dijk; Vesa M Olkkonen; Anneke van Der Zee; Jari Metso; L Havekes; Matti Jauhiainen; Christian Ehnholm
Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;128(4):781-92.
2001: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
The impact of phospholipid transfer protein (PLTP) on HDL metabolism.
Atherosclerosis 2001;155(2):269-81.
2000: J Huuskonen; Vesa M Olkkonen; Christian Ehnholm; Jari Metso; I Julkunen; Matti Jauhiainen
Phospholipid transfer is a prerequisite for PLTP-mediated HDL conversion.
Biochemistry 2000;39(51):16092-8.
2000: Sanna Lehtonen; Ari Ora; Vesa M Olkkonen; L Geng; M Zerial; S Somlo; Eero Lehtonen
In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2.
The Journal of biological chemistry 2000;275(42):32888-93.
2000: Vesa M Olkkonen; Elina Ikonen
Genetic defects of intracellular-membrane transport.
The New England journal of medicine 2000;343(15):1095-104.
2000: T Oka; Takeshi Kujiraoka; M Ito; Tohru Egashira; S Takahashi; M Nazeem Nanjee; Norman E Miller; Jari Metso; Vesa M Olkkonen; Christian Ehnholm; Matti Jauhiainen; H Hattori
Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive.
Journal of lipid research 2000;41(10):1651-7.
2000: J Huuskonen; M Ekström; Esa Tahvanainen; A Vainio; Jari Metso; Pirkko J Pussinen; Christian Ehnholm; Vesa M Olkkonen; Matti Jauhiainen
Quantification of human plasma phospholipid transfer protein (PLTP): relationship between PLTP mass and phospholipid transfer activity.
Atherosclerosis 2000;151(2):451-61.
2000: Sanna Heino; Sari Lusa / Löytökorpi; Pentti Somerharju; Christian Ehnholm; Vesa M Olkkonen; Elina Ikonen
Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8375-80.
2000: K Riento; M Kauppi; S Keranen; Vesa M Olkkonen
Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells.
The Journal of biological chemistry 2000;275(18):13476-83.
1999: Saara Laitinen; Vesa M Olkkonen; Christian Ehnholm; Elina Ikonen
Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.
Journal of lipid research 1999;40(12):2204-11.
1999: Beatriz Quiñones; K Riento; Vesa M Olkkonen; S Hardy; MK Bennett
Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations.
Journal of cell science 1999;112 ( Pt 23)():4291-304.
1999: Sanna Lehtonen; K Riento; Vesa M Olkkonen; Eero Lehtonen
Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development.
Kidney international 1999;56(3):815-26.
1999: J Huuskonen; Gerd Wohlfahrt; Matti Jauhiainen; Christian Ehnholm; O Teleman; Vesa M Olkkonen
Structure and phospholipid transfer activity of human PLTP: analysis by molecular modeling and site-directed mutagenesis.
Journal of lipid research 1999;40(6):1123-30.
1999: Matti Jauhiainen; J Huuskonen; M Baumann; Jari Metso; T Oka; Tohru Egashira; H Hattori; Vesa M Olkkonen; Christian Ehnholm
Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I.
Journal of lipid research 1999;40(4):654-64.
1999: Jussi Jäntti; J Lahdenranta; Vesa M Olkkonen; Hans Söderlund; Sirkka Keränen
SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):909-14.
1999: Sanna Lehtonen; Eero Lehtonen; Vesa M Olkkonen
Vesicular transport and kidney development.
The International journal of developmental biology 1999;43(5):425-33.
1998: J Huuskonen; Matti Jauhiainen; Christian Ehnholm; Vesa M Olkkonen
Biosynthesis and secretion of human plasma phospholipid transfer protein.
Journal of lipid research 1998;39(10):2021-30.
1998: Sanna Lehtonen; Vesa M Olkkonen; M Stapleton; M Zerial; Eero Lehtonen
HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.
The International journal of developmental biology 1998;42(6):775-82.
1998: K Riento; Thierry Galli; S Jansson; C Ehnholm; Eero Lehtonen; Vesa M Olkkonen
Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells.
Journal of cell science 1998;111 ( Pt 17)():2681-8.
1998: Sonja Jaari; Ko Willems van Dijk; B van 't Hof; Anneke van Der Zee; Vesa M Olkkonen; Matti Jauhiainen; Marten H Hofker; L Havekes; Christian Ehnholm
Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice.
Journal of lipid research 1998;39(6):1248-53.
1998: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; T Sareneva; Pentti Somerharju; Christian Ehnholm
Oxidative modification of HDL3 in vitro and its effect on PLTP-mediated phospholipid transfer.
Biochimica et biophysica acta 1998;1391(2):181-92.
1997: S Jansson; Vesa M Olkkonen; L Martin-Parras; P Chavrier; M Stapleton; M Zerial; Eero Lehtonen
Mouse metanephric kidney as a model system for identifying developmentally regulated genes.
Journal of cellular physiology 1997;173(2):147-51.
1997: Pirkko J Pussinen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein.
Journal of lipid research 1997;38(7):1473-81.
1997: T Koivu; Saara Laitinen; K Riento; Vesa M Olkkonen
Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs.
DNA sequence : the journal of DNA sequencing and mapping 1997;7(3-4):217-20.
1996: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; Jari Metso; Pentti Somerharju; Christian Ehnholm
Acyl chain and headgroup specificity of human plasma phospholipid transfer protein.
Biochimica et biophysica acta 1996;1303(3):207-14.
1996: K Riento; Jussi Jäntti; S Jansson; S Hielm; Eero Lehtonen; C Ehnholm; Sirkka Keränen; Vesa M Olkkonen
A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells.
European journal of biochemistry / FEBS 1996;239(3):638-46.
1996: J Toikkanen; E Gatti; K Takei; Markku Saloheimo; Vesa M Olkkonen; H Söderlund; Pietro De Camilli; Sirkka Keränen
Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit.
Yeast (Chichester, England) 1996;12(5):425-38.
1995: Cecilia Bucci; A Lütcke; Olivia Steele-Mortimer; Vesa M Olkkonen; Paul Dupree; M Chiariello; Carmelo B Bruni; Kai Simons; Marino Zerial
Co-operative regulation of endocytosis by three Rab5 isoforms.
FEBS letters 1995;366(1):65-71.
1995: A Lütcke; Vesa M Olkkonen; Paul Dupree; H Lütcke; Kai Simons; Marino Zerial
Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific small GTPase.
Gene 1995;155(2):257-60.
1994: Jussi Jäntti; Sirkka Keränen; J Toikkanen; Esa Kuismanen; C Ehnholm; H Söderlund; Vesa M Olkkonen
Membrane insertion and intracellular transport of yeast syntaxin Sso2p in mammalian cells.
Journal of cell science 1994;107 ( Pt 12)():3623-33.
1994: A Lütcke; Robert Parton; Carol Murphy; Vesa M Olkkonen; Paul Dupree; A Valencia; Kai Simons; Marino Zerial
Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression.
Journal of cell science 1994;107 ( Pt 12)():3437-48.
1994: L A Huber; O Ullrich; Y Takai; A Lütcke; Paul Dupree; Vesa M Olkkonen; H Virta; M J de Hoop; K Alexandrov; M Peter
Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):7874-8.
1994: Vesa M Olkkonen; Jeffrey Peterson; Paul Dupree; A Lütcke; Marino Zerial; Kai Simons
Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain.
Gene 1994;138(1-2):207-11.
1994: M J de Hoop; Vesa M Olkkonen; E Ikonen; E Williamson; C von Poser; L Meyn; Carlos G Dotti
Semliki Forest virus as a tool for protein expression in cultured rat hippocampal neurons.
Gene therapy 1994;1 Suppl 1():S28-31.
1994: Vesa M Olkkonen; Paul Dupree; Kai Simons; P Liljeström; Henrik Garoff
Expression of exogenous proteins in mammalian cells with the Semliki Forest virus vector.
Methods in cell biology 1994;43 Pt A():43-53.
1993: Vesa M Olkkonen; Paul Dupree; I Killisch; A Lütcke; Marino Zerial; Kai Simons
Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily.
Journal of cell science 1993;106 ( Pt 4)():1249-61.
1993: Jaana K H Bamford; Cheng Luo; Jarmo T Juuti; Vesa M Olkkonen; Dennis H Bamford
Topology of the major capsid protein P3 of bacteriophage PRD1: analysis using monoclonal antibodies and C-terminally truncated proteins.
Virology 1993;197(2):652-8.
1993: Vesa M Olkkonen; P Liljeström; Henrik Garoff; Kai Simons; Carlos G Dotti
Expression of heterologous proteins in cultured rat hippocampal neurons using the Semliki Forest virus vector.
Journal of neuroscience research 1993;35(4):445-51.
1993: Tiina Pakula; Javier Caldentey; C Gutiérrez; Vesa M Olkkonen; M Salas; Dennis H Bamford
Overproduction, purification, and characterization of DNA-binding protein P19 of bacteriophage PRD1.
Gene 1993;126(1):99-104.
1992: Paul Dupree; Vesa M Olkkonen; Philippe Chavrier
Sequence of a canine cDNA clone encoding a Ran/TC4 GTP-binding protein.
Gene 1992;120(2):325-6.
1992: shiroh onodera; Vesa M Olkkonen; P Gottlieb; J Strassman; Xueying Qiao; Dennis H Bamford; Leonard Mindich
Construction of a transducing virus from double-stranded RNA bacteriophage phi6: establishment of carrier states in host cells.
Journal of virology 1992;66(1):190-6.
1992: Kai Simons; Paul Dupree; Klaus Fiedler; L A Huber; T Kobayashi; Teymuras V Kurzchalia; Vesa M Olkkonen; Sanjay Pimplikar; Robert Parton; Carlos G Dotti
Biogenesis of cell-surface polarity in epithelial cells and neurons.
Cold Spring Harbor symposia on quantitative biology 1992;57():611-9.
1991: Vesa M Olkkonen; Päivi M Ojala; Dennis H Bamford
Generation of infectious nucleocapsids by in vitro assembly of the shell protein on to the polymerase complex of the dsRNA bacteriophage phi 6.
Journal of molecular biology 1991;218(3):569-81.
1990: Vesa M Olkkonen; P Gottlieb; J Strassman; Xueying Qiao; Dennis H Bamford; Leonard Mindich
In vitro assembly of infectious nucleocapsids of bacteriophage phi 6: formation of a recombinant double-stranded RNA virus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9173-7.
1989: Vesa M Olkkonen; Dennis H Bamford
Quantitation of the adsorption and penetration stages of bacteriophage phi 6 infection.
Virology 1989;171(1):229-38.
1988: Vesa M Olkkonen; P M Pekkala; Dennis H Bamford
Monoclonal antibodies to the major structural proteins of bacteriophage phi 6.
Virology 1988;165(1):317-20.
1988: Martin Romantschuk; Vesa M Olkkonen; Dennis H Bamford
The nucleocapsid of bacteriophage phi 6 penetrates the host cytoplasmic membrane.
The EMBO journal 1988;7(6):1821-9.