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Piero Olliaro

Research Profile

Chemicals & Drugs

Disorders

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Drug Therapy, Combination

Physiology

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Piero Olliaro; Michel Vaillant; Byron Arana; Pierre Buffet; Max Grogl; Olivier Lapujade; Alan Magill; Farrokh Modabber; Jorge Alvar
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis.
Eva Maria Staehli Hodel; Monia Guidi; Abdunoor Mulokozi Kabanywanyi; Piero Olliaro; Frédéric Ariey; Hans-Peter Beck; Chantal Csajka; Laurent Arthur Decosterd; Socheat Duong; Blaise Genton
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Tina Kauss; Xavier Lafarge; Jean-Michel Léger; Martine Lembege; Niklas Lindegardh; Muriel Manse; Stephane Massip; Pascal Millet; Piero Olliaro; Nicholas J White; Boubakar B Ba; Jean-Michel Boiron; Chantal Boyer; Fawaz Fawaz; Alexandra Gaubert; Karen Gaudin
Pharmaceutical development and optimization of azithromycin suppository for paediatric use.

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2013: Piero Olliaro; Michel Vaillant; Byron Arana; Pierre Buffet; Max Grogl; Olivier Lapujade; Alan Magill; Farrokh Modabber; Jorge Alvar
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis.
PLoS neglected tropical diseases 2013;7(3):e2130.
2013: Eva Maria Staehli Hodel; Monia Guidi; Abdunoor Mulokozi Kabanywanyi; Piero Olliaro; Frédéric Ariey; Hans-Peter Beck; Chantal Csajka; Laurent Arthur Decosterd; Socheat Duong; Blaise Genton
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Antimicrobial agents and chemotherapy 2013;57(2):950-8.
2013: Tina Kauss; Xavier Lafarge; Jean-Michel Léger; Martine Lembege; Niklas Lindegardh; Muriel Manse; Stephane Massip; Pascal Millet; Piero Olliaro; Nicholas J White; Boubakar B Ba; Jean-Michel Boiron; Chantal Boyer; Fawaz Fawaz; Alexandra Gaubert; Karen Gaudin
Pharmaceutical development and optimization of azithromycin suppository for paediatric use.
International journal of pharmaceutics 2013;441(1-2):218-26.
2012: Sara Finaurini; Richard K Haynes; Piero Olliaro; Silvia Parapini; Nicoletta Basilico; Yolanda Corbett; Sarah D'Alessandro; Donatella Taramelli
Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.
Toxicology 2012;300(1-2):57-66.
2012: Chantal Boyer; Jacques Boucher; Abdelhakim Boudis; Mickaël Franc; Alexandra Gaubert; Karen Gaudin; Tina Kauss; Pascal Millet; Piero Olliaro; Julie Roussille; Justine Verschelden; Nicholas J White; Jean-Pierre Dubost
Development of NIRS method for quality control of drug combination artesunate-azithromycin for the treatment of severe malaria.
Journal of pharmaceutical and biomedical analysis 2012;67-68():10-5.
2012: Julien Zwang; Sodiomon B Sirima; Abdoulaye Djimdé; Grant Dorsey; Corine Karema; Andreas Mårtensson; Jean-Louis Ndiaye; Piero Olliaro
Clinical tolerability of artesunate-amodiaquine versus comparator treatments for uncomplicated falciparum malaria: an individual-patient analysis of eight randomized controlled trials in sub-Saharan Africa.
Malaria journal 2012;11():260.
2012: Piero Olliaro; Shyam Sundar; Michel T Vaillant; Manica Balasegaram
More efficient ways of assessing treatments for neglected tropical diseases are required: innovative study designs, new endpoints, and markers of effects.
PLoS neglected tropical diseases 2012;6(5):e1545.
2012: Corinne S C Merle; Denis A Mitchinson; Joseph Odhiambo; Piero Olliaro; Christian Perronne; Francoise Portaels; Roxana Rustomjee; Charalambos Sismanidis; Oumou Bah Sow; M Gninafon; John Horton; Olivier Lapujade; Christian Lienhardt; Mame Bocar Lo; Katherine Fielding
A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the Gatifloxacin for TB (OFLOTUB) project.
Trials 2012;13():61.
2012: Julien Zwang; Abdoulaye Djimdé; Grant Dorsey; Corine Karema; Andreas Mårtensson; Jean-Louis Ndiaye; Piero Olliaro
Comparing changes in haematologic parameters occurring in patients included in randomized controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa.
Malaria journal 2012;11():25.
2011: Piero Olliaro; Sodiomon B Sirima; Michel Vaillant; Abdoulaye Djimdé; Grant Dorsey; Corine Karema; Andreas Mårtensson; Jean-Louis Ndiaye; Julien Zwang
Hematologic parameters in pediatric uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.
The American journal of tropical medicine and hygiene 2011;85(4):619-25.
2011: Michael Woelfle; Piero Olliaro; Matthew H Todd
Open science is a research accelerator.
Nature chemistry 2011;3(10):745-8.
2011: Michael Woelfle; Jesse de Gooijer; Piero Olliaro; Kees Pouwer; Jean-Paul Seerden; Matthew H Todd
Resolution of praziquantel.
PLoS neglected tropical diseases 2011;5(9):e1260.
2011: Piero Olliaro; Jürg Seiler; Annette Kuesel; Jeffrey N Clark; Robert Don; John Horton; Jennifer Keiser
Potential drug development candidates for human soil-transmitted helminthiases.
PLoS neglected tropical diseases 2011;5(6):e1138.
2011: Piero Olliaro; Abdoulaye Djimdé; Corine Karema; Andreas Mårtensson; Jean-Louis Ndiaye; Sodiomon B Sirima; Grant Dorsey; Julien Zwang
Standardised versus actual white cell counts in estimating thick film parasitaemia in African children under five.
Tropical medicine & international health : TM & IH 2011;16(5):551-4.
2011: Srivicha Krudsood; Sornchai Looareesuwan; P Wilairatama; Wattana Leowattana; Noppadon Tangpukdee; Kobsiri Chalermrut; S Ramanathan; V Navaratnam; Piero Olliaro; M Vaillant; J R Kiechel; W R J Taylor
Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand.
Tropical medicine & international health : TM & IH 2011;16(4):458-65.
2011: Shyam Sundar; Prabhat Kumar Sinha; Madhukar Rai; Deepak Kumar Verma; Kumar Nawin; Shanawwaj Alam; Jaya Chakravarty; Michel Vaillant; Neena Verma; Krishna Pandey; Poonam Kumari; Chandra Shekhar Lal; Rakesh Arora; Bhawna Sharma; Sally Ellis; Nathalie Strub-Wourgaft; Manica Balasegaram; Piero Olliaro; Pradeep Das; Farrokh Modabber
Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial.
Lancet 2011;377(9764):477-86.
2011: Philippe Brasseur; Moustafa Cisse; Patrice Agnamey; Malick Badiane; Michel T Vaillant; Piero Olliaro
Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal.
Malaria journal 2011;10():203.
2011: David Sinclair; Felicity Brand; Nithya Gogtay; Piero Olliaro
Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria.
Cochrane database of systematic reviews (Online) 2011;(7):CD008492.
2011: Katharine Abba; Jonathan J Deeks; Sarah Donegan; Sally M Jackson; Cho-Min Naing; Piero Olliaro; Yemisi Takwoingi; Paul Garner
Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries.
Cochrane database of systematic reviews (Online) 2011;(7):CD008122.
2011: Catherine Lacaze; Visweswaran Navaratnam; Piero Olliaro; Laurent Terrassin; Nick J White; Antonella Caminiti; Sylvie Cuart; Fawaz Fawaz; Karen Gaudin; Bellabes Ghezzoul; Luc Grislain; Tina Kauss; Jean-René Kiechel; Pascal Millet
The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership.
Malaria journal 2011;10():142.
2011: Felista Mwingira; Gamba Nkwengulila; Sonja Schoepflin; Deborah Sumari; Hans-Peter Beck; Georges Snounou; Ingrid Felger; Piero Olliaro; Kefas Mugittu
Plasmodium falciparum msp1, msp2 and glurp allele frequency and diversity in sub-Saharan Africa.
Malaria journal 2011;10():79.
2011: Dorothee Heemskerk; Jeremy Day; Tran Thi Hong Chau; Nguyen Huy Dung; Nguyen Thi Bich Yen; Nguyen Duc Bang; Laura Merson; Piero Olliaro; Thomas Pouplin; Maxine Caws; Marcel Wolbers; Jeremy Farrar
Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial.
Trials 2011;12():25.
2010: Shabir Banoo; David Bell; Patrick Bossuyt; Alan Herring; David Mabey; Freddie Poole; Peter G Smith; N Sriram; Chansuda Wongsrichanalai; Ralf Linke; Rick O'Brien; Mark Perkins; Jane Cunningham; Precious Matsoso; Carl Michael Nathanson; Piero Olliaro; Rosanna W Peeling; Andy Ramsay
Evaluation of diagnostic tests for infectious diseases: general principles.
Nature reviews. Microbiology 2010;8(12 Suppl):S17-29.
2010: Piero Olliaro; Michel T Vaillant
Alternative visual displays of metaanalysis of malaria treatment trials to facilitate translation of research into policy.
Diagnostic microbiology and infectious disease 2010;68(4):422-31.
2010: Eva Maria Hodel; Blaise Genton; Boris Zanolari; Thomas Mercier; Socheat Duong; Hans-Peter Beck; Piero Olliaro; Laurent Arthur Decosterd; Frédéric Ariey
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
The Journal of infectious diseases 2010;202(7):1088-94.
2010: Tina Kauss; Fawaz Fawaz; Michel Guyot; Anne-Marie Lagueny; Isabelle Dos Santos; François Bonini; Piero Olliaro; Antonella Caminiti; Pascal Millet
Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria.
International journal of pharmaceutics 2010;395(1-2):198-204.
2010: Kasia Stepniewska; Elizabeth A Ashley; Sue J Lee; Nicholas Anstey; Karen I Barnes; Tran Quang Binh; Umberto D'Alessandro; Nicholas P J Day; Peter de Vries; Grant Dorsey; Jean-Paul Guthmann; Mayfong Mayxay; Paul N Newton; Piero Olliaro; Lyda Osorio; Ric Price; Mark Rowland; Frank Smithuis; Walter R J Taylor; François Nosten; Nicholas J White
In vivo parasitological measures of artemisinin susceptibility.
The Journal of infectious diseases 2010;201(4):570-9.
2010: Filip Meheus; Manica Balasegaram; Piero Olliaro; Pinky Tripathi; Suman Rijal; Md Abul Faiz; Marleen Boelaert
Cost-effectiveness analysis of combination therapies for visceral leishmaniasis in the Indian subcontinent.
PLoS neglected tropical diseases 2010;4(9):.
2010: Nicoletta Basilico; Silvia Parapini; Francesca Sisto; Fausta Omodeo-Salè; Paolo Coghi; Fernando Ravagnani; Piero Olliaro; Donatella Taramelli
The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1.
Journal of biomedicine & biotechnology 2010;2010():854927.
2010: Karen Gaudin; Pascal Millet; Fawaz Fawaz; Piero Olliaro; Nicholas J White; Céline Cassus-Coussère; Ulrich Agbahoungha; Jean-Pierre Dubost
Investigation of porous graphitic carbon at high-temperature liquid chromatography with evaporative light scattering detection for the analysis of the drug combination artesunate--azithromycin for the treatment of severe malaria.
Journal of chromatography. A 2010;1217(1):75-81.
2009: Anthony Danso-Appiah; Paul Garner; Piero Olliaro; Jürg Utzinger
Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review.
Parasitology 2009;136(13):1837-49.
2009: Piero Olliaro; Sarah Darley; Ramanan Laxminarayan; Shyam Sundar
Cost-effectiveness projections of single and combination therapies for visceral leishmaniasis in Bihar, India.
Tropical medicine & international health : TM & IH 2009;14(8):918-25.
2009: Visweswaran Navaratnam; Surash Ramanathan; Mohd Suhaimi Ab Wahab; Siew Hua Gan; Sharif Mansor; Jean-René Kiechel; Michel Vaillant; Walter R J Taylor; Piero Olliaro
Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers.
European journal of clinical pharmacology 2009;65(8):809-21.
2009: Paul Garner; Hellen Gelband; Patricia Graves; Katharine Jones; Harriet Maclehose; Piero Olliaro
Systematic reviews in malaria: global policies need global reviews.
Infectious disease clinics of North America 2009;23(2):387-404, Table of Contents.
2009: Piero Olliaro
Management of fever and malaria - policy and practice.
Tropical medicine & international health : TM & IH 2009;14(5):488-90.
2009: Choon-Sheen Lai; NK Nair; A Muniandy; Sharif Mansor; Piero Olliaro; Visweswaran Navaratnam
Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(5-6):558-62.
2009: M F Gomes; M A Faiz; J O Gyapong; Marian Warsame; T Agbenyega; A Babiker; F Baiden; E B Yunus; F Binka; C Clerk; P Folb; R Hassan; M A Hossain; O Kimbute; A Kitua; S Krishna; C Makasi; N Mensah; Z Mrango; Piero Olliaro; R Peto; T J Peto; M R Rahman; Isabela Ribeiro; R Samad; N J White
Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial.
Lancet 2009;373(9663):557-66.
2009: Eva Maria Hodel; Abdunoor Mulokozi Kabanywanyi; Aggrey Malila; Boris Zanolari; Thomas Mercier; Hans-Peter Beck; Thierry Buclin; Piero Olliaro; Laurent Arthur Decosterd; Blaise Genton
Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.
PloS one 2009;4(12):e8184.
2009: Julien Zwang; Piero Olliaro; hubert Barennes; Maryline Bonnet; Philippe Brasseur; Hasifa Bukirwa; Sandra Cohuet; Umberto D'Alessandro; Abdulaye Djimdé; Corine Karema; Jean-Paul Guthmann; Sally Hamour; Jean-Louis Ndiaye; Andreas Mårtensson; Claude Rwagacondo; Issaka Sagara; Albert Same-Ekobo; Sodiomon B Sirima; Ingrid van den Broek; Adoke Yeka; Walter R J Taylor; Grant Dorsey; Milijaona Randrianarivelojosia
Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis.
Malaria journal 2009;8():203.
2009: David Sinclair; Babalwa Zani; Sarah Donegan; Piero Olliaro; Paul Garner
Artemisinin-based combination therapy for treating uncomplicated malaria.
Cochrane database of systematic reviews (Online) 2009;(3):CD007483.
2009: Stéphane Picot; Piero Olliaro; Frédérique de Monbrison; Anne-Lise Bienvenu; Ric Price; Pascal Ringwald
A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria.
Malaria journal 2009;8():89.
2008: Pinky Tripathi; Madhukar Rai; Jaya Chakravarty; DK Agarwal; N Agrawal; Michel Vaillant; Piero Olliaro; Henry W Murray
New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(8):1000-6.
2008: Monica Longo; Sara Zanoncelli; Paola Della Torre; Francesco Rosa; AnnaMaria Giusti; Paolo Colombo; Marco Brughera; Guy Mazué; Piero Olliaro
Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX).
Reproductive toxicology (Elmsford, N.Y.) 2008;25(4):433-41.
2008: Piero Olliaro
Editorial commentary: mortality associated with severe Plasmodium falciparum malaria increases with age.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(2):158-60.
2008: Catherine Orrell; Francesca Little; Peter Smith; Peter I Folb; Walter Taylor; Piero Olliaro; Karen I Barnes
Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers.
European journal of clinical pharmacology 2008;64(7):683-90.
2008: Piero Olliaro
Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(7):992-3.
2008: Elizabeth A Ashley; Loretxu Pinoges; Eleanor Turyakira; Grant Dorsey; Francesco Checchi; Hasifa Bukirwa; Ingrid van den Broek; Issaka Zongo; Pedro Pablo Palma Urruta; Michel van Herp; Suna Balkan; Walter R J Taylor; Piero Olliaro; Jean-Paul Guthmann
Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.
Malaria journal 2008;7():154.
2008: Sue J Lee; Kasia Stepniewska; Nicholas Anstey; Elizabeth A Ashley; Karen Barnes; Tran Quang Binh; Umberto D'Alessandro; Nicholas P J Day; Peter de Vries; Grant Dorsey; Jean-Paul Guthmann; Mayfong Mayxay; Paul Newton; François Nosten; Piero Olliaro; Lyda Osario; Loretxu Pinoges; Ric Price; Mark Rowland; Frank Smithuis; Robert Taylor; Nicholas J White
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.
Malaria journal 2008;7():149.
2008: Anthony Danso-Appiah; Jürg Utzinger; Jianping Liu; Piero Olliaro
Drugs for treating urinary schistosomiasis.
Cochrane database of systematic reviews (Online) 2008;(3):CD000053.
2008: Piero Olliaro; Loretxu Pinoges; Francesco Checchi; Michel Vaillant; Jean-Paul Guthmann
Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment.
Tropical medicine & international health : TM & IH 2008;13(1):83-90.
2007: Piero Olliaro; Philippe Brasseur
[Treatment of malaria: outlook].
Bulletin de l'Académie nationale de médecine 2007;191(7):1285-92.
2007: Choon-Sheen Lai; NK Nair; Sharif Mansor; Piero Olliaro; Visweswaran Navaratnam
An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;857(2):308-14.
2007: Charles O Obonyo; W Taylor; H Ekvall; A Kaneko; Feiko O ter Kuile; Piero Olliaro; Anders Bjorkman; James OLOO
Effect of artesunate plus sulfadoxine-pyrimethamine on haematological recovery and anaemia, in Kenyan children with uncomplicated, Plasmodium falciparum malaria.
Annals of tropical medicine and parasitology 2007;101(4):281-95.
2007: Kefas Mugittu; Gerardo Priotto; Jean-Paul Guthmann; James Kiguli; Martin Adjuik; Georges Snounou; Hans-Peter Beck; Hassan Mshinda; Piero Olliaro; Walter R J Taylor
Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment.
Tropical medicine & international health : TM & IH 2007;12(2):219-23.
2007: Michel Vaillant; Piero Olliaro
Geometric least squares means ratios for the analysis of Plasmodium falciparum in vitro susceptibility to antimalarial drugs.
Malaria journal 2007;6():156.
2007: Jean-Marie Kindermans; Jacques Pilloy; Piero Olliaro; Melba Gomes
Ensuring sustained ACT production and reliable artemisinin supply.
Malaria journal 2007;6():125.
2007: Karen I Barnes; Niklas Lindegardh; Olumide Ogundahunsi; Piero Olliaro; Christopher Plowe; Milijaona Randrianarivelojosia; Grace O Gbotosho; William M Watkins; Carol Hopkins Sibley; Nicholas J White
World Antimalarial Resistance Network (WARN) IV: clinical pharmacology.
Malaria journal 2007;6():122.
2007: Ric Price; Grant Dorsey; Elizabeth A Ashley; Karen I Barnes; J Kevin Baird; Umberto D'Alessandro; Philippe Guerin; Miriam K Laufer; Inbarani Naidoo; François Nosten; Piero Olliaro; Christopher Plowe; Pascal Ringwald; Carol Hopkins Sibley; Kasia Stepniewska; Nicholas J White
World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs.
Malaria journal 2007;6():119.
2007: Jean-Marie Kindermans; Daniel Vandenbergh; Ed Vreeke; Piero Olliaro; Jean-Pierre D'Altilia
Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs).
Malaria journal 2007;6():91.
2007: Lyda Osorio; Iveth Gonzalez; Piero Olliaro; Walter R J Taylor
Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.
Malaria journal 2007;6():25.
2006: Shabir Banoo; David Bell; Patrick Bossuyt; Alan Herring; David Mabey; Freddie Poole; Peter G Smith; N Sriram; Chansuda Wongsrichanalai; Ralf Linke; Rick O'Brien; Mark Perkins; Jane Cunningham; Precious Matsoso; Carl-Michael Nathanson; Piero Olliaro; Rosanna W Peeling; Andrew Ramsay
Evaluation of diagnostic tests for infectious diseases: general principles.
Nature reviews. Microbiology 2006;4(12 Suppl):S20-32.
2006: Walter R J Taylor; Dianne J Terlouw; Piero Olliaro; Nicholas J White; Philippe Brasseur; Feiko O ter Kuile
Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria.
Bulletin of the World Health Organization 2006;84(12):956-64.
2006: David Lalloo; Peju Olukoya; Piero Olliaro
Malaria in adolescence: burden of disease, consequences, and opportunities for intervention.
The Lancet infectious diseases 2006;6(12):780-93.
2006: Julie A Simpson; Tsiri Agbenyega; Karen I Barnes; Gianni Di Perri; Peter I Folb; Melba Gomes; Sanjeev Krishna; Srivicha Krudsood; Sornchai Looareesuwan; Sharif Mansor; Helen McIlleron; Raymond Miller; Malcolm E Molyneux; James Mwenechanya; Visweswaran Navaratnam; François Nosten; Piero Olliaro; Lorrin Pang; Isabela Ribeiro; Madalitso Tembo; Michele van Vugt; Steve Ward; Kris Weerasuriya; Kyaw Win; Nicholas J White
Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.
PLoS medicine 2006;3(11):e444.
2006: Elizabeth A Ashley; Khin Maung Lwin; Rose McGready; Win Htay Simon; Lucy Phaiphun; Stephane Proux; Nantawan Wangseang; Walter Taylor; Kasia Stepniewska; Wimon Nawamaneerat; Kyaw Lay Thwai; Marion Barends; Wattana Leowattana; Piero Olliaro; Pratap Singhasivanon; Nicholas J White; François Nosten
An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
Tropical medicine & international health : TM & IH 2006;11(11):1653-60.
2006: Monica Longo; Sara Zanoncelli; Paola Della Torre; Mariagrazia Riflettuto; Francesco Cocco; Manuela Pesenti; Annamaria Giusti; Paolo Colombo; Marco Brughera; Guy Mazué; Visweswaran Navaratman; Melba Gomes; Piero Olliaro
In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos.
Reproductive toxicology (Elmsford, N.Y.) 2006;22(4):797-810.
2006: Jean-Paul Guthmann; Loretxu Pinoges; Francesco Checchi; Simon Cousens; Suna Balkan; Michel van Herp; Dominique Legros; Piero Olliaro
Methodological issues in the assessment of antimalarial drug treatment: analysis of 13 studies in eight African countries from 2001 to 2004.
Antimicrobial agents and chemotherapy 2006;50(11):3734-9.
2006: Shabir Banoo; David Bell; Patrick Bossuyt; Alan Herring; David Mabey; Freddie Poole; Peter G Smith; N Sriram; Chansuda Wongsrichanalai; Ralf Linke; Rick O'Brien; Mark Perkins; Jane Cunningham; Precious Matsoso; Carl-Michael Nathanson; Piero Olliaro; Rosanna W Peeling; Andrew Ramsay
Evaluation of diagnostic tests for infectious diseases: general principles.
Nature reviews. Microbiology 2006;4(9 Suppl):S21-31.
2006: Kefas Mugittu; Martin Adjuik; Georges Snounou; Francine Ntoumi; Walter Taylor; Hassan Mshinda; Piero Olliaro; Hans-Peter Beck
Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness.
Tropical medicine & international health : TM & IH 2006;11(9):1350-9.
2006: Patrice Agnamey; Philippe Brasseur; Philippe Eldin de Pécoulas; Michel Vaillant; Piero Olliaro
Plasmodium falciparum in vitro susceptibility to antimalarial drugs in Casamance (southwestern Senegal) during the first 5 years of routine use of artesunate-amodiaquine.
Antimicrobial agents and chemotherapy 2006;50(4):1531-4.
2006: Jorge Alvar; Simon Croft; Piero Olliaro
Chemotherapy in the treatment and control of leishmaniasis.
Advances in parasitology 2006;61():223-74.
2006: Monica Longo; Sara Zanoncelli; Debora Manera; Marco Brughera; Paolo Colombo; Jacqueline Lansen; Guy Mazué; Melba Gomes; Walter R J Taylor; Piero Olliaro
Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro.
Reproductive toxicology (Elmsford, N.Y.) 2006;21(1):83-93.
2005: Piero Olliaro; Philippe Guerin; Sibylle Gerstl; Astrid Aga Haaskjold; John-Arne Rottingen; Shyam Sundar
Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004.
The Lancet infectious diseases 2005;5(12):763-74.
2005: Andreas Mårtensson; Johan Strömberg; Christin Sisowath; Mwinyi Msellem; J Pedro Gil; Scott M Montgomery; Piero Olliaro; Abdullah S Ali; Anders Björkman
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(8):1079-86.
2005: S Ramanathan; S Karupiah; NK Nair; Piero Olliaro; Visweswaran Navaratnam; W H Wernsdorfer; Sharif Mansor
A new and simple solid-phase extraction method for LC determination of pyronaridine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;824(1-2):45-50.
2005: Patrice Agnamey; Philippe Brasseur; M Cisse; O Gaye; J Dumoulin; Jean Rigal; Walter R J Taylor; Piero Olliaro
Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.
Tropical medicine & international health : TM & IH 2005;10(9):926-33.
2005: Piero Olliaro
Drug resistance hampers our capacity to roll back malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41 Suppl 4():S247-57.
2005: christophe biot; Donatella Taramelli; Isabelle Forfar-Bares; Lucien A Maciejewski; Mlandzeni Boyce; Guy Nowogrocki; Jacques Brocard; Nicoletta Basilico; Piero Olliaro; Timothy J Egan
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
Molecular pharmaceutics 2005;2(3):185-93.
2004: Piero Olliaro
Congenital toxoplasmosis.
Clinical evidence 2004;(12):1058-61.
2004: Innocent Safeukui; François Mangou; Denis Malvy; Philippe Vincendeau; Djavad Mossalayi; Gilbert Haumont; Remi VATAN; Piero Olliaro; Pascal Millet
Plasmodium berghei: dehydroepiandrosterone sulfate reverses chloroquino-resistance in experimental malaria infection; correlation with glucose 6-phosphate dehydrogenase and glutathione synthesis pathway.
Biochemical pharmacology 2004;68(10):1903-10.
2004: Kasia Stepniewska; Walter R J Taylor; Mayfong Mayxay; Ric Price; Frank Smithuis; Jean-Paul Guthmann; Karen Barnes; Hla Yin Myint; Martin Adjuik; Piero Olliaro; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Tran Tinh Hien; Jeremy Farrar; François Nosten; Nicholas P J Day; Nicholas J White
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.
Antimicrobial agents and chemotherapy 2004;48(11):4271-80.
2004: Silvia Parapini; Nicoletta Basilico; Monica Mondani; Piero Olliaro; Donatella Taramelli; Diego Monti
Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.
FEBS letters 2004;575(1-3):91-4.
2004: Piero Olliaro; Peter G Smith
The European and developing countries clinical trails partnership.
Journal of HIV therapy 2004;9(3):53-6.
2004: Martin Adjuik; A Babiker; P Garner; Piero Olliaro; W Taylor; N White
Artesunate combinations for treatment of malaria: meta-analysis.
Lancet 2004;363(9402):9-17.
2004: Piero Olliaro; Walter R J Taylor
Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review.
Journal of postgraduate medicine 2004;50(1):40-4.
2003: Piero Olliaro; Walter R J Taylor
Antimalarial compounds: from bench to bedside.
The Journal of experimental biology 2003;206(Pt 21):3753-9.
2003: Charles O Obonyo; Francis Ochieng; Walter R J Taylor; Samuel A Ochola; Kefas Mugitu; Piero Olliaro; Feiko O ter Kuile; James OLOO
Artesunate plus sulfadoxine-pyrimethamine for uncomplicated malaria in Kenyan children: a randomized, double-blind, placebo-controlled trial.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(5):585-91.
2003: Walter R Taylor; Jean Rigal; Piero Olliaro
Drug resistant falciparum malaria and the use of artesunate-based combinations: focus on clinical trials sponsored by TDR.
Journal of vector borne diseases 2003;40(3-4):65-72.
2003: Fausta Omodeo-Salè; Anna Motti; Nicoletta Basilico; Silvia Parapini; Piero Olliaro; Donatella Taramelli
Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum.
Blood 2003;102(2):705-11.
2003: Piero Olliaro
Congenital toxoplasmosis.
Clinical evidence 2003;(9):763-6.
2003: Gerardo Priotto; Jerome Kabakyenga; Loretxu Pinoges; Ana Ruiz; Therese Eriksson; François Coussement; Tharcise Ngambe; Walter R J Taylor; William Perea; Jean-Paul Guthmann; Piero Olliaro; Dominique Legros
Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(3):325-30.
2003: Lorenz Von Seidlein; Gijs Walraven; Paul Milligan; Neal Alexander; Fandingding Manneh; Jacqueline L Deen; Roz Coleman; Musa Jawara; Steven W Lindsay; Chris Drakeley; Sarah De Martin; Piero Olliaro; Steve Bennett; Maarten Schim van der Loeff; Kunle Okunoye; Geoffrey A T Targett; Keith P W J McAdam; Justin F Doherty; Brian M Greenwood; Margaret Pinder
The effect of mass administration of sulfadoxine-pyrimethamine combined with artesunate on malaria incidence: a double-blind, community-randomized, placebo-controlled trial in The Gambia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(2):217-25.
2003: Richard K Haynes; Diego Monti; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Piero Olliaro
Artemisinin antimalarials do not inhibit hemozoin formation.
Antimicrobial agents and chemotherapy 2003;47(3):1175.
2003: Piero Olliaro; Robert G Ridley; Jurgen Engel; Herbert Sindermann; Anthony Bryceson
Miltefosine in visceral leishmaniasis.
The Lancet infectious diseases 2003;3(2):70.
2003: Piero Olliaro; P Mussano
Amodiaquine for treating malaria.
Cochrane database of systematic reviews (Online) 2003;(2):CD000016.
2002: Piero Olliaro
Congenital toxoplasmosis.
Clinical evidence 2002;(8):680-3.
2002: Philippe Guerin; Piero Olliaro; François Nosten; Pierre Druilhe; Ramanan Laxminarayan; Fred Binka; Wen L Kilama; Nathan Ford; Nicholas J White
Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development.
The Lancet infectious diseases 2002;2(9):564-73.
2002: Philippe Guerin; Piero Olliaro; Pinky Tripathi; Marleen Boelaert; Simon L Croft; Philippe Desjeux; Monique K Wasunna; Anthony Bryceson
Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.
The Lancet infectious diseases 2002;2(8):494-501.
2002: Diego Monti; Nicoletta Basilico; Silvia Parapini; Erica Pasini; Piero Olliaro; Donatella Taramelli
Does chloroquine really act through oxidative stress?
FEBS letters 2002;522(1-3):3-5.
2002: Patrice Trouiller; Piero Olliaro; Els Torreele; James Orbinski; Richard Laing; Nathan Ford
Drug development for neglected diseases: a deficient market and a public-health policy failure.
Lancet 2002;359(9324):2188-94.
2002: Piero Olliaro
Congenital toxoplasmosis.
Clinical evidence 2002;(7):623-6.
2002: Piero Olliaro; Janis Lazdins; Felipe Guhl
Developments in the treatment of leishmaniasis and trypanosomiasis.
Expert opinion on emerging drugs 2002;7(1):61-7.
2002: Martin Adjuik; Patrice Agnamey; A Babiker; Steffen Borrmann; Philippe Brasseur; M Cisse; Frank G J Cobelens; S Diallo; Jean-François Faucher; P Garner; S Gikunda; Song Le; Sanjeev Krishna; Bertrand Lell; M Loolpapit; Pierre-Blaise Matsiegui; Michel A Missinou; J Mwanza; Francine Ntoumi; Piero Olliaro; P Osimbo; Philipp Rezbach; E Some; Walter R J Taylor
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.
Lancet 2002;359(9315):1365-72.
2001: Patrice Trouiller; Els Torreele; Piero Olliaro; N White; S Foster; D Wirth; B Pécoul
Drugs for neglected diseases: a failure of the market and a public health failure?
Tropical medicine & international health : TM & IH 2001;6(11):945-51.
2001: Piero Olliaro; Walter R J Taylor; Jean Rigal
Controlling malaria: challenges and solutions.
Tropical medicine & international health : TM & IH 2001;6(11):922-7.
2001: Catherine Orrell; W R Taylor; Piero Olliaro
Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(5):517-8.
2001: Fausta Omodeo-Salè; Diego Monti; Piero Olliaro; Donatella Taramelli
Prooxidant activity of beta-hematin (synthetic malaria pigment) in arachidonic acid micelles and phospholipid large unilamellar vesicles.
Biochemical pharmacology 2001;61(8):999-1009.
2001: Piero Olliaro
Mode of action and mechanisms of resistance for antimalarial drugs.
Pharmacology & therapeutics 2001;89(2):207-19.
2001: Piero Olliaro; NK Nair; K Sathasivam; Sharif Mansor; Visweswaran Navaratnam
Pharmacokinetics of artesunate after single oral administration to rats.
BMC pharmacology 2001;1():12.
2001: Piero Olliaro; R Vijayan; K Inbasegaran; C C Lang; S Looareesuwan
Drug studies in developing countries.
Bulletin of the World Health Organization 2001;79(9):894-5.
2000: Silvia Parapini; Nicoletta Basilico; Erica Pasini; Timothy J Egan; Piero Olliaro; Donatella Taramelli; Diego Monti
Standardization of the physicochemical parameters to assess in vitro the beta-hematin inhibitory activity of antimalarial drugs.
Experimental parasitology 2000;96(4):249-56.
2000: Donatella Taramelli; Stefania Recalcati; Nicoletta Basilico; Piero Olliaro; Gaetano Cairo
Macrophage preconditioning with synthetic malaria pigment reduces cytokine production via heme iron-dependent oxidative stress.
Laboratory investigation; a journal of technical methods and pathology 2000;80(12):1781-8.
2000: P Wilairatna; Srivicha Krudsood; Udomsak Silachamroon; Pratap Singhasivanon; Suparp Vannaphan; S Faithong; M Klabprasit; S N Bangchang; Piero Olliaro; Sornchai Looareesuwan
Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand.
The American journal of tropical medicine and hygiene 2000;63(5-6):290-4.
2000: Chandreshwar P Thakur; TP Kanyok; AK Pandey; GP Sinha; C Messick; Piero Olliaro
Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized phase-II clinical study.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(4):432-3.
2000: Chandreshwar P Thakur; TP Kanyok; AK Pandey; GP Sinha; A E Zaniewski; H H Houlihan; Piero Olliaro
A prospective randomized, comparative, open-label trial of the safety and efficacy of paromomycin (aminosidine) plus sodium stibogluconate versus sodium stibogluconate alone for the treatment of visceral leishmaniasis.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(4):429-31.
2000: Lorenz Von Seidlein; Paul Milligan; Margaret Pinder; Kalifa Bojang; C Anyalebechi; R Gosling; Rosalind Coleman; J I Ude; AD Sadiq; Manoj T Duraisingh; david charles warhurst; Ali Alloueche; Geoffrey A T Targett; Keith P W J McAdam; Brian Greenwood; Gijs Walraven; Piero Olliaro; Tom Doherty
Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial.
Lancet 2000;355(9201):352-7.
2000: HM McIntosh; Piero Olliaro
Artemisinin derivatives for treating severe malaria.
Cochrane database of systematic reviews (Online) 2000;(2):CD000527.
2000: HM McIntosh; Piero Olliaro
Artemisinin derivatives for treating uncomplicated malaria.
Cochrane database of systematic reviews (Online) 2000;(2):CD000256.
2000: Piero Olliaro; P Mussano
Amodiaquine for treating malaria.
Cochrane database of systematic reviews (Online) 2000;(2):CD000016.
1999: Donatella Taramelli; Diego Monti; Nicoletta Basilico; Silvia Parapini; F Omodeo-Salé; Piero Olliaro
A fine balance between oxidised and reduced haem controls the survival of intraerythrocytic plasmodia.
Parassitologia 1999;41(1-3):205-8.
1999: Justin F Doherty; AD Sadiq; L Bayo; Ali Alloueche; Piero Olliaro; Paul Milligan; Lorenz Von Seidlein; Margaret Pinder
A randomized safety and tolerability trial of artesunate plus sulfadoxine--pyrimethamine versus sulfadoxine-pyrimethamine alone for the treatment of uncomplicated malaria in Gambian children.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1999;93(5):543-6.
1999: Diego Monti; B Vodopivec; Nicoletta Basilico; Piero Olliaro; Donatella Taramelli
A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites.
Biochemistry 1999;38(28):8858-63.
1999: Nicholas J White; François Nosten; Sornchai Looareesuwan; William M Watkins; K Marsh; R W Snow; Gilbert O Kokwaro; J Ouma; Tran Tinh Hien; M E Molyneux; Terrie E Taylor; C I Newbold; Trenton K Ruebush; M Danis; B M Greenwood; R M Anderson; Piero Olliaro
Averting a malaria disaster.
Lancet 1999;353(9168):1965-7.
1999: Piero Olliaro; Y Yuthavong
An overview of chemotherapeutic targets for antimalarial drug discovery.
Pharmacology & therapeutics 1999;81(2):91-110.
1998: Fausta Omodeo-Salè; Nicoletta Basilico; M Folini; Piero Olliaro; Donatella Taramelli
Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by beta-haematin (malaria pigment).
FEBS letters 1998;433(3):215-8.
1998: Nicoletta Basilico; E Pagani; Diego Monti; Piero Olliaro; Donatella Taramelli
A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs.
The Journal of antimicrobial chemotherapy 1998;42(1):55-60.
1998: Sornchai Looareesuwan; Piero Olliaro; Nicholas J White; Tan Chongsuphajaisiddhi; A Sabcharoen; Krongthong Thimasarn; François Nosten; Pratap Singhasivanon; Suvanee Supavej; Srisin Khusmith; Steven Wayling; TP Kanyok; D Walsh; PA Leggat; E B Doberstyn
Consensus recommendation on the treatment of malaria in Southeast Asia.
The Southeast Asian journal of tropical medicine and public health 1998;29(2):355-60.
1998: Tara Kant Jha; Piero Olliaro; Chandreshwar P Thakur; TP Kanyok; B L Singhania; I J Singh; N K Singh; S Akhoury; S Jha
Randomised controlled trial of aminosidine (paromomycin) v sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India.
BMJ (Clinical research ed.) 1998;316(7139):1200-5.
1998: Melba Gomes; Piero Olliaro; Peter I Folb
What role can public health institutions play in drug development for the poor? A case study of artesunate.
Médecine tropicale : revue du Corps de santé colonial 1998;58(3 Suppl):97-100.
1998: HM McIntosh; Piero Olliaro
Treatment of severe malaria with artemisinin derivatives. A systematic review of randomised controlled trials.
Médecine tropicale : revue du Corps de santé colonial 1998;58(3 Suppl):61-2.
1998: HM McIntosh; Piero Olliaro
Treatment of uncomplicated malaria with artemisinin derivatives. A systematic review of randomised controlled trials.
Médecine tropicale : revue du Corps de santé colonial 1998;58(3 Suppl):57-8.
1998: Nicholas J White; Piero Olliaro
Artemisinin and derivatives in the treatment of uncomplicated malaria.
Médecine tropicale : revue du Corps de santé colonial 1998;58(3 Suppl):54-6.
1998: Donatella Taramelli; Nicoletta Basilico; A M De Palma; Marina Saresella; P Ferrante; Luciana Mussoni; Piero Olliaro
The effect of synthetic malaria pigment (beta-haematin) on adhesion molecule expression and interleukin-6 production by human endothelial cells.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(1):57-62.
1997: Sornchai Looareesuwan; Polrat Wilairatana; W Molunto; Kobsiri Chalermrut; Piero Olliaro; M Andrial
A comparative clinical trial of sequential treatments of severe malaria with artesunate suppository followed by mefloquine in Thailand.
The American journal of tropical medicine and hygiene 1997;57(3):348-53.
1997: Nicoletta Basilico; Diego Monti; Piero Olliaro; Donatella Taramelli
Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation.
FEBS letters 1997;409(2):297-9.
1995: Donatella Taramelli; Nicoletta Basilico; E Pagani; Romualdo Grande; Diego Monti; M Ghione; Piero Olliaro
The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages.
Experimental parasitology 1995;81(4):501-11.