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Françoise Benoit-Vical

Research Profile

Chemicals & Drugs

Disorders

Physiology

Drug Resistance

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Inhibitory Concentration 50

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Genes & Molecular Sequences

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Publications

TOP 3
Catherine Hemmert; Françoise Benoit-Vical; Aymeric Fabié; Aude Fabre; Heinz Gornitzka
Synthesis, structures, and antimalarial activities of some silver(I), gold(I) and gold(III) complexes involving N-heterocyclic carbene ligands.
Benoit Witkowski; Odile Mercereau-Puijalon; Pascal Ringwald; Rupam Tripura; Frédéric Ariey; Jean-Christophe Barale; Françoise Benoit-Vical; Antoine Berry; Pheaktra Chim; Sophy Chy; Arjen M Dondorp; Socheat Duong; Olivier Gorgette; Sopheakvatey Ke; Nimol Khim; Saorin Kim; Nimol Kloeung; Rithea Leang; Didier Menard
Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
Odile Dechy-Cabaret; Françoise Benoit-Vical
Effects of antimalarial molecules on the gametocyte stage of Plasmodium falciparum: the debate.

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All Publications

2013: Catherine Hemmert; Françoise Benoit-Vical; Aymeric Fabié; Aude Fabre; Heinz Gornitzka
Synthesis, structures, and antimalarial activities of some silver(I), gold(I) and gold(III) complexes involving N-heterocyclic carbene ligands.
European journal of medicinal chemistry 2013;60():64-75.
2013: Benoit Witkowski; Odile Mercereau-Puijalon; Pascal Ringwald; Rupam Tripura; Frédéric Ariey; Jean-Christophe Barale; Françoise Benoit-Vical; Antoine Berry; Pheaktra Chim; Sophy Chy; Arjen M Dondorp; Socheat Duong; Olivier Gorgette; Sopheakvatey Ke; Nimol Khim; Saorin Kim; Nimol Kloeung; Rithea Leang; Didier Menard
Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
Antimicrobial agents and chemotherapy 2013;57(2):914-23.
2012: Odile Dechy-Cabaret; Françoise Benoit-Vical
Effects of antimalarial molecules on the gametocyte stage of Plasmodium falciparum: the debate.
Journal of medicinal chemistry 2012;55(23):10328-44.
2012: Patrice Njomnang Soh; Bernard Pipy; Benoit Witkowski; Antoine Berry; Amandine Gales; Eric Huyghe; Françoise Benoit-Vical
Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid.
PloS one 2012;7(9):e45906.
2012: Sandie Menard; Isabelle Morlais; Collins Sayang; Rachida Tahar; Parfait Awono-Ambene; Leonardo K Basco; Françoise Benoit-Vical; Xavier Iriart; Brigitte Lemen; Jean-François Magnaval; Pembe Issamou Mayengue; Antoine Berry
Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future.
Malaria journal 2012;11():113.
2012: Benoit Witkowski; Antoine Berry; Fatima Bousejra-Elgarah; Xavier Iriart; Joel Lelièvre; Bernard Meunier; Marie-Laure Nicolau-Travers; Patrice Njomnang Soh; Françoise Benoit-Vical
Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.
PloS one 2012;7(3):e32620.
2012: Aurélie Pascual; Stéphane Picot; Christophe Rogier; Fabrice Simon; Didier Basset; Françoise Benoit-Vical; Nathalie Bourgeois; Pascal Delaunay; Eric Didillon; Bernard Faugère; Denis Malvy; Danièle Maubon; Guillaume Ménard; Claude Oeuvray; Philippe Parola; Bruno Pradines
Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.
Malaria journal 2012;11():45.
2011: Charlotte Passemar; Christiane Poupat; Mariette Saléry; Patrice Njomnang Soh; Alain Ahond; Marie-Denise Linas; Françoise Benoit-Vical
Indole and aminoimidazole moieties appear as key structural units in antiplasmodial molecules.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(13):1118-25.
2011: David Olagnier; Bernhard Ryffel; Agnès Aubouy; Françoise Benoit-Vical; Antoine Berry; Agnès Coste; Christophe Dardenne; Rose-Anne Lavergne; Lise Lefèvre; Etienne Meunier; Bernard Pipy
Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria.
PLoS pathogens 2011;7(9):e1002254.
2011: Antoine Berry; Xavier Iriart; Nathalie Wilhelm; Alexis Valentin; Sophie Cassaing; Benoit Witkowski; Françoise Benoit-Vical; Sandie Menard; David Olagnier; Judith Fillaux; Stephane Sire; Alain Le Coustumier; Jean-François Magnaval
Imported Plasmodium knowlesi malaria in a French tourist returning from Thailand.
The American journal of tropical medicine and hygiene 2011;84(4):535-8.
2011: Merlin Willcox; Françoise Benoit-Vical; Geneviève Bourdy; Gemma Burford; Dennis Fowler; Sergio Giani; Rocky Graziose; Peter Houghton; Milijaona Randrianarivelojosia; Philippe Rasoanaivo
Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?
Malaria journal 2011;10 Suppl 1():S7.
2010: Benoit Witkowski; Xavier Iriart; Patrice Njomnang Soh; Sandie Menard; Muriel Alvarez; Veronique Naneix-Laroche; Bruno Marchou; Jean-François Magnaval; Françoise Benoit-Vical; Antoine Berry
pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies.
Journal of clinical microbiology 2010;48(10):3797-9.
2010: Benoit Witkowski; Marie-Laure Nicolau; Patrice Njomnang Soh; Xavier Iriart; Sandie Menard; Muriel Alvarez; Bruno Marchou; Jean-François Magnaval; Françoise Benoit-Vical; Antoine Berry
Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.
Antimicrobial agents and chemotherapy 2010;54(7):3049-51.
2010: Benoit Witkowski; Joel Lelièvre; Maria Jose Lopez Barragan; Victor Laurent; Xin-zhuan Su; Antoine Berry; Françoise Benoit-Vical
Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism.
Antimicrobial agents and chemotherapy 2010;54(5):1872-7.
2009: Patrice Njomnang Soh; Benoît Witkowski; David Olagnier; Marie-Laure Nicolau; Maria-Concepcion Garcia-Alvarez; Antoine Berry; Françoise Benoit-Vical
In vitro and in vivo properties of ellagic acid in malaria treatment.
Antimicrobial agents and chemotherapy 2009;53(3):1100-6.
2009: Benoit Witkowski; Antoine Berry; Françoise Benoit-Vical
Resistance to antimalarial compounds: methods and applications.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2009;12(1-2):42-50.
2009: Antoine Berry; Caroline Deymier; Mathieu Sertorio; Benoît Witkowski; Françoise Benoit-Vical
Pfs 16 pivotal role in Plasmodium falciparum gametocytogenesis: a potential antiplasmodial drug target.
Experimental parasitology 2009;121(2):189-92.
2008: Jean-Théophile Banzouzi; Patrice Njomnang Soh; Bernard Mbatchi; Adrien Cavé; Suzanne Ramos; Pascal Retailleau; Olga Rakotonandrasana; Antoine Berry; Françoise Benoit-Vical
Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.
Planta medica 2008;74(12):1453-6.
2008: Fatima Bousejra-El Garah; Catherine Claparols; Françoise Benoit-Vical; Bernard MEUNIER; Anne Robert
The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.
Antimicrobial agents and chemotherapy 2008;52(8):2966-9.
2008: Françoise Benoit-Vical; Mariette Saléry; Patrice Njomnang Soh; Alain Ahond; Christiane Poupat
Girolline: a potential lead structure for antiplasmodial drug research.
Planta medica 2008;74(4):438-44.
2008: Françoise Benoit-Vical; P Njomnang Soh; M Saléry; L Harguem; C Poupat; R Nongonierma
Evaluation of Senegalese plants used in malaria treatment: focus on Chrozophora senegalensis.
Journal of ethnopharmacology 2008;116(1):43-8.
2008: Clotilde Ribaut; Antoine Berry; Séverine Chevalley; Karine Reybier; Isabelle Morlais; Daniel Parzy; Françoise Nepveu; Françoise Benoit-Vical; alexis valentin
Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species.
Malaria journal 2008;7():45.
2007: David Olagnier; Philippe Costes; Antoine Berry; Marie-Denise Linas; Martine Urrutigoity; Odile Dechy-Cabaret; Françoise Benoit-Vical
Modifications of the chemical structure of terpenes in antiplasmodial and antifungal drug research.
Bioorganic & medicinal chemistry letters 2007;17(22):6075-8.
2007: Patrice Njomnang Soh; Françoise Benoit-Vical
Are West African plants a source of future antimalarial drugs?
Journal of ethnopharmacology 2007;114(2):130-40.
2007: Christophe Loup; Joël Lelièvre; Françoise Benoit-Vical; Bernard MEUNIER
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.
Antimicrobial agents and chemotherapy 2007;51(10):3768-70.
2007: G Martin-Blondel; M Barry; Lydie Porte; F Busato; Patrice Massip; Françoise Benoit-Vical; Antoine Berry; Bruno Marchou
[Impact of HIV infection on malaria in adults].
Médecine et maladies infectieuses 2007;37(10):629-36.
2007: Antoine Berry; Patricia Balard; Agnès Coste; David Olagnier; Céline Lagane; Hélène Authier; Françoise Benoit-Vical; Jean-Claude Lepert; Jean-Paul Séguéla; Jean-François Magnaval; Pierre Chambon; Daniel Metzger; Béatrice Desvergne; Walter Wahli; Johan Auwerx; Bernard Pipy
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.
European journal of immunology 2007;37(6):1642-52.
2007: Françoise Benoit-Vical; Joël Lelièvre; Antoine Berry; Caroline Deymier; Odile Dechy-Cabaret; Jérôme Cazelles; Christophe Loup; Anne Robert; Jean-François Magnaval; Bernard MEUNIER
Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.
Antimicrobial agents and chemotherapy 2007;51(4):1463-72.
2007: Joël Lelièvre; Antoine Berry; Françoise Benoit-Vical
Artemisinin and chloroquine: do mode of action and mechanism of resistance involve the same protagonists?
Current opinion in investigational drugs (London, England : 2000) 2007;8(2):117-24.
2006: Antoine Berry; A Senescau; Joël Lelièvre; Françoise Benoit-Vical; Richard Fabre; Bruno Marchou; Jean-François Magnaval
Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(10):986-8.
2006: Françoise Benoit-Vical; P Grellier; A Abdoulaye; I Moussa; A Ousmane; Antoine Berry; K Ikhiri; C Poupat
In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture.
Chemotherapy 2006;52(6):288-92.
2005: Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard MEUNIER
The antimalarial drug artemisinin alkylates heme in infected mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13676-80.
2005: Alice Senescau; Antoine Berry; Françoise Benoit-Vical; Olfert Landt; Richard Fabre; Joël Lelièvre; Sophie Cassaing; Jean-François Magnaval
Use of a locked-nucleic-acid oligomer in the clamped-probe assay for detection of a minority Pfcrt K76T mutant population of Plasmodium falciparum.
Journal of clinical microbiology 2005;43(7):3304-8.
2005: Antoine Berry; G Chene; Françoise Benoit-Vical; Jean-Claude Lepert; José Bernad; Bruno Marchou; Jean-Paul Séguéla; Jean-François Magnaval; Bernard Pipy
Ex vivo and in vitro impairment of CD36 expression and tumor necrosis factor-alpha production in human monocytes in response to Plasmodium falciparum-parasitized erythrocytes.
The Journal of parasitology 2005;91(2):316-22.
2005: Joël Lelièvre; Antoine Berry; Françoise Benoit-Vical
An alternative method for Plasmodium culture synchronization.
Experimental parasitology 2005;109(3):195-7.
2005: Antoine Berry; Richard Fabre; Françoise Benoit-Vical; Sophie Cassaing; Jean-François Magnaval
Contribution of PCR-based methods to diagnosis and management of imported malaria.
Médecine tropicale : revue du Corps de santé colonial 2005;65(2):176-83.
2005: Françoise Benoit-Vical
Ethnomedicine in malaria treatment.
IDrugs : the investigational drugs journal 2005;8(1):45-52.
2004: Antoine Berry; Aurélia Vessière; Richard Fabre; Françoise Benoit-Vical; Bruno Marchou; Patrice Massip; Jean-François Magnaval
Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2004;4(4):361-4.
2004: Aurélia Vessière; Antoine Berry; Richard Fabre; Françoise Benoit-Vical; Jean-François Magnaval
Detection by real-time PCR of the Pfcrt T76 mutation, a molecular marker of chloroquine-resistant Plasmodium falciparum strains.
Parasitology research 2004;93(1):5-7.
2004: Odile Dechy-Cabaret; Françoise Benoit-Vical; Christophe Loup; Anne Robert; Heinz Gornitzka; Anne Bonhoure; Henri VIAL; Jean-François Magnaval; Jean-Paul Séguéla; Bernard MEUNIER
Synthesis and antimalarial activity of trioxaquine derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(7):1625-36.
2003: Françoise Benoit-Vical; alexis valentin; B Da; Z Dakuyo; L Descamps; Michèle Mallié
N'Dribala (Cochlospermum planchonii) versus chloroquine for treatment of uncomplicated Plasmodium falciparum malaria.
Journal of ethnopharmacology 2003;89(1):111-4.
2003: Laurence Delhaes; Françoise Benoit-Vical; Daniel Camus; Monique Capron; Bernard Meunier
Chloroquine and artemisinin: six decades of research--what next?
IDrugs : the investigational drugs journal 2003;6(7):674-80.
2003: Françoise Benoit-Vical; Christine Imbert; Jean-Paul Bonfils; Yves Sauvaire
Antiplasmodial and antifungal activities of iridal, a plant triterpenoid.
Phytochemistry 2003;62(5):747-51.
2002: Ingrid Jacquemond-Collet; Françoise Benoit-Vical; alexis valentin; Edouard Stanislas; Michèle Mallié; Isabelle Fourasté
Antiplasmodial and cytotoxic activity of galipinine and other tetrahydroquinolines from Galipea officinalis.
Planta medica 2002;68(1):68-9.
2000: Odile Dechy-Cabaret; Françoise Benoit-Vical; Anne Robert; Bernard MEUNIER
Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline.
Chembiochem : a European journal of chemical biology 2000;1(4):281-3.
2000: alexis valentin; Françoise Benoit-Vical; Yves Pélissier; D Koné-Bamba; Michèle Mallié
Antiplasmodial activity of plant extracts used in west African traditional medicine.
Journal of ethnopharmacology 2000;73(1-2):145-51.
2000: Françoise Benoit-Vical; A Robert; Bernard MEUNIER
In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins.
Antimicrobial agents and chemotherapy 2000;44(10):2836-41.
2000: Françoise Benoit-Vical; Maud Santillana-Hayat; D Kone-Bamba; M Mallie; Francis Derouin
Anti-Toxoplasma activity of vegetal extracts used in West African traditional medicine.
Parasite (Paris, France) 2000;7(1):3-7.
1999: Françoise Benoit-Vical; A Robert; Bernard MEUNIER
Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.
Antimicrobial agents and chemotherapy 1999;43(10):2555-8.
1999: Françoise Benoit-Vical; alexis valentin; Michèle Mallié; Jean-Marie Bastide; J M Bessière
In vitro antimalarial activity and cytotoxicity of cochlospermum tinctorium and C. planchonii leaf extracts and essential oils.
Planta medica 1999;65(4):378-81.
1998: Françoise Benoit-Vical; alexis valentin; V Cournac; Yves Pélissier; Michèle Mallié; Jean-Marie Bastide
In vitro antiplasmodial activity of stem and root extracts of Nauclea latifolia S.M. (Rubiaceae).
Journal of ethnopharmacology 1998;61(3):173-8.
1997: alexis valentin; Françoise Benoit-Vical; Claude Moulis; Edouard Stanislas; Michèle Mallié; I Fouraste; Jean-Marie Bastide
In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.
Antimicrobial agents and chemotherapy 1997;41(10):2305-7.