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Jean-Pierre Benoit

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Julien Balzeau; Jean-Pierre Benoit; Raphael Berges; Maud Pinier; Patrick Saulnier; Joël Eyer
The effect of functionalizing lipid nanocapsules with NFL-TBS.40-63 peptide on their uptake by glioblastoma cells.
Samuli Hirsjärvi; Véronique Josserand; Catherine Passirani; lucie sancey; Isabelle Texier; Qiao Yan; Jean-Pierre Benoit; Jérôme Bibette; Sandrine Dufort; Julien Gravier; Jean-Luc Coll
Influence of size, surface coating and fine chemical composition on the in vitro reactivity and in vivo biodistribution of lipid nanocapsules versus lipid nanoemulsions in cancer models.
Elodie Moysan; Guillaume Bastiat; Jean-Pierre Benoit
Gemcitabine versus Modified Gemcitabine: a review of several promising chemical modifications.

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2013: Julien Balzeau; Jean-Pierre Benoit; Raphael Berges; Maud Pinier; Patrick Saulnier; Joël Eyer
The effect of functionalizing lipid nanocapsules with NFL-TBS.40-63 peptide on their uptake by glioblastoma cells.
Biomaterials 2013;34(13):3381-9.
2013: Samuli Hirsjärvi; Véronique Josserand; Catherine Passirani; lucie sancey; Isabelle Texier; Qiao Yan; Jean-Pierre Benoit; Jérôme Bibette; Sandrine Dufort; Julien Gravier; Jean-Luc Coll
Influence of size, surface coating and fine chemical composition on the in vitro reactivity and in vivo biodistribution of lipid nanocapsules versus lipid nanoemulsions in cancer models.
Nanomedicine : nanotechnology, biology, and medicine 2013;9(3):375-87.
2013: Elodie Moysan; Guillaume Bastiat; Jean-Pierre Benoit
Gemcitabine versus Modified Gemcitabine: a review of several promising chemical modifications.
Molecular pharmaceutics 2013;10(2):430-44.
2013: Stephanie David; Mathieu Mevel; Tristan Montier; Marie Morille; Catherine Passirani; Jean-Pierre Benoit; Nathalie Carmoy; Benoit Chatin; Bruno Pitard
DNA nanocarriers for systemic administration: characterization and in vivo bioimaging in healthy mice.
Molecular therapy. Nucleic acids 2013;2():e64.
2012: Stephanie David; mathieu mével; Tristan Montier; Jean-Pierre Benoit; Nathalie Carmoy; Anne Clavreul; Bruno Pitard; Pauline Resnier; Catherine Passirani
Treatment efficacy of DNA lipid nanocapsules and DNA multimodular systems after systemic administration in a human glioma model.
The journal of gene medicine 2012;14(12):769-75.
2012: Marie-Anne Cosson; Claire Goulvestre; Clémence Martin; Marie-Rose Moro; Capucine Picard; Claire Poyart; Stéphane Silvera; Nicolas Veziris; Jean-Pierre Benoit; Jean-Baptiste Bertrand; Sophie Coignard; Philippe C Morand
Temporal interferon-gamma release response to Mycobacterium kansasii infection in an anorexia nervosa patient.
Journal of medical microbiology 2012;61(Pt 11):1617-20.
2012: Sandy Vrignaud; Séverine Wack; Jean-Pierre Benoit; José Hureaux; Patrick Saulnier
Design, optimization and in vitro evaluation of reverse micelle-loaded lipid nanocarriers containing erlotinib hydrochloride.
International journal of pharmaceutics 2012;436(1-2):194-200.
2012: Anne-Laure Laine; Anne Vessières; Julien Balzeau; Jérôme Béjaud; Jean-Pierre Benoit; Anne Clavreul; Joël Eyer; Ngoc Trinh Huynh; Catherine Passirani
Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;81(3):690-3.
2012: Erika Bourseau-Guilmain; Jean-Pierre Benoit; François Berger; Audrey Griveau; Eric Hervouet; Laurent Lemaire; philippe menei; François Vallette; didier wion; EMMANUEL GARCION
In vitro expansion of human glioblastoma cells at non-physiological oxygen tension irreversibly alters subsequent in vivo aggressiveness and AC133 expression.
International journal of oncology 2012;40(4):1220-9.
2012: E Bourseau-Guilmain; J Béjaud; Jean-Pierre Benoit; A Griveau; François Hindré; N Lautram; M Weyland; EMMANUEL GARCION
Development and characterization of immuno-nanocarriers targeting the cancer stem cell marker AC133.
International journal of pharmaceutics 2012;423(1):93-101.
2012: Ngoc Trinh Huynh; Laurent Lemaire; Catherine Passirani; Jerome Roux; Anne Vessières; Emilie Allard-Vannier; EMMANUEL GARCION; Jean-Pierre Benoit
Administration-dependent efficacy of ferrociphenol lipid nanocapsules for the treatment of intracranial 9L rat gliosarcoma.
International journal of pharmaceutics 2012;423(1):55-62.
2011: Ngoc Trinh Huynh; Gérard Jaouen; Pierre Legras; Marie Morille; Jerome Bejaud; Jean-Pierre Benoit; Anne Vessières; Catherine Passirani
Treatment of 9L gliosarcoma in rats by ferrociphenol-loaded lipid nanocapsules based on a passive targeting strategy via the EPR effect.
Pharmaceutical research 2011;28(12):3189-98.
2011: FRANCK LACOEUILLE; M Sergent; Marie-Claire Venier-Julienne; S Askienazy; Jean-Pierre Benoit; F Bouchet; O F Couturier; Benoit Denizot; François Hindré; S Jouaneton; J J Le Jeune
A starch-based microparticulate system dedicated to diagnostic and therapeutic nuclear medicine applications.
Biomaterials 2011;32(31):7999-8009.
2011: Sandy Vrignaud; Nicolas Anton; Jean-Pierre Benoit; Pascal Gayet; Patrick Saulnier
Reverse micelle-loaded lipid nanocarriers: a novel drug delivery system for the sustained release of doxorubicin hydrochloride.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;79(1):197-204.
2011: Emilie Roger; frederic Lagarce; Jean-Pierre Benoit
Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;79(1):181-8.
2011: M Weyland; F Manero; A Paillard; D Grée; G Viault; D Jarnet; philippe menei; P Juin; Igor Chourpa; Jean-Pierre Benoit; R Grée; EMMANUEL GARCION
Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1.
Journal of controlled release : official journal of the Controlled Release Society 2011;151(1):74-82.
2011: Marie Morille; Catherine Passirani; Sandrine Dufort; Guillaume Bastiat; Bruno Pitard; Jean-Luc Coll; Jean-Pierre Benoit
Tumor transfection after systemic injection of DNA lipid nanocapsules.
Biomaterials 2011;32(9):2327-33.
2011: Erika Bourseau-Guilmain; Jean-Pierre Benoit; Audrey Griveau; EMMANUEL GARCION
The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.
PloS one 2011;6(9):e25515.
2010: S Vinchon-Petit; D Jarnet; S Michalak; A Lewis; Jean-Pierre Benoit; philippe menei
Local implantation of doxorubicin drug eluting beads in rat glioma.
International journal of pharmaceutics 2010;402(1-2):184-9.
2010: Samuli Hirsjärvi; Yan Qiao; Audrey Royere; Jérôme Bibette; Jean-Pierre Benoit
Layer-by-layer surface modification of lipid nanocapsules.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;76(2):200-7.
2010: Archibald Paillard; François Hindré; Caroline Vignes-Colombeix; Jean-Pierre Benoit; EMMANUEL GARCION
The importance of endo-lysosomal escape with lipid nanocapsules for drug subcellular bioavailability.
Biomaterials 2010;31(29):7542-54.
2010: Sandrine Vinchon-Petit; Delphine Jarnet; Archibald Paillard; Jean-Pierre Benoit; EMMANUEL GARCION; philippe menei
In vivo evaluation of intracellular drug-nanocarriers infused into intracranial tumours by convection-enhanced delivery: distribution and radiosensitisation efficacy.
Journal of neuro-oncology 2010;97(2):195-205.
2010: José Hureaux; frederic Lagarce; Frédéric Gagnadoux; Marie-Christine Rousselet; Valérie Moal; Thierry Urban; Jean-Pierre Benoit
Toxicological study and efficacy of blank and paclitaxel-loaded lipid nanocapsules after i.v. administration in mice.
Pharmaceutical research 2010;27(3):421-30.
2010: Gaëtan J-R Delcroix; Paul C Schiller; Jean-Pierre Benoit; Claudia Montero-Menei
Adult cell therapy for brain neuronal damages and the role of tissue engineering.
Biomaterials 2010;31(8):2105-20.
2010: Emilie Roger; frederic Lagarce; EMMANUEL GARCION; Jean-Pierre Benoit
Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery.
Nanomedicine (London, England) 2010;5(2):287-306.
2010: FRANCK LACOEUILLE; François Hindré; Benoit Denizot; Francis Bouchet; Pierre Legras; Olivier Couturier; Serge Askiénazy; Jean-Pierre Benoit; Jean Jacques Le Jeune
New starch-based radiotracer for lung perfusion scintigraphy.
European journal of nuclear medicine and molecular imaging 2010;37(1):146-55.
2009: M Morille; Catherine Passirani; E Letrou-Bonneval; Jean-Pierre Benoit; B Pitard
Galactosylated DNA lipid nanocapsules for efficient hepatocyte targeting.
International journal of pharmaceutics 2009;379(2):293-300.
2009: E Allard; N T Huynh; Anne Vessières; P Pigeon; Gérard Jaouen; Jean-Pierre Benoit; Catherine Passirani
Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model.
International journal of pharmaceutics 2009;379(2):317-23.
2009: N T Huynh; Catherine Passirani; Patrick Saulnier; Jean-Pierre Benoit
Lipid nanocapsules: a new platform for nanomedicine.
International journal of pharmaceutics 2009;379(2):201-9.
2009: Arnaud Vonarbourg; Catherine Passirani; Léa Desigaux; Emilie Allard; Patrick Saulnier; Olivier Lambert; Jean-Pierre Benoit; Bruno Pitard
The encapsulation of DNA molecules within biomimetic lipid nanocapsules.
Biomaterials 2009;30(18):3197-204.
2009: Catherine Chapon; florence franconi; FRANCK LACOEUILLE; François Hindré; Patrick Saulnier; Jean-Pierre Benoit; Jean-Jacques Le Jeune; Laurent Lemaire
Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent.
Magma (New York, N.Y.) 2009;22(3):167-74.
2009: Emilie Allard; Catherine Passirani; Jean-Pierre Benoit
Convection-enhanced delivery of nanocarriers for the treatment of brain tumors.
Biomaterials 2009;30(12):2302-18.
2008: E Allard; F Hindre; Catherine Passirani; L Lemaire; Nicolas Lepareur; Nicolas Noiret; philippe menei; Jean-Pierre Benoit
188Re-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas.
European journal of nuclear medicine and molecular imaging 2008;35(10):1838-46.
2008: Emilie Allard; Catherine Passirani; EMMANUEL GARCION; Pascal Pigeon; Anne Vessières; Gérard Jaouen; Jean-Pierre Benoit
Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas.
Journal of controlled release : official journal of the Controlled Release Society 2008;130(2):146-53.
2008: Alexandra Giteau; Marie-Claire Venier-Julienne; Stéphane Marchal; Jean-Luc Courthaudon; Michèle Sergent; Claudia Montero-Menei; Jean-Michel Verdier; Jean-Pierre Benoit
Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(1):127-36.
2008: Marie Morille; Catherine Passirani; Arnaud Vonarbourg; Anne Clavreul; Jean-Pierre Benoit
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.
Biomaterials 2008;29(24-25):3477-96.
2008: Nicolas Anton; Jean-Pierre Benoit; Patrick Saulnier
Design and production of nanoparticles formulated from nano-emulsion templates-a review.
Journal of controlled release : official journal of the Controlled Release Society 2008;128(3):185-99.
2008: Arnaud Béduneau; François Hindré; Anne Clavreul; Jean-Christophe Leroux; Patrick Saulnier; Jean-Pierre Benoit
Brain targeting using novel lipid nanovectors.
Journal of controlled release : official journal of the Controlled Release Society 2008;126(1):44-9.
2007: Kristina Mladenovska; O Cruaud; P Richomme; E Belamie; R S Raicki; Marie-Claire Venier-Julienne; E Popovski; Jean-Pierre Benoit; Katerina Goracinova
5-ASA loaded chitosan-Ca-alginate microparticles: Preparation and physicochemical characterization.
International journal of pharmaceutics 2007;345(1-2):59-69.
2007: FRANCK LACOEUILLE; EMMANUEL GARCION; Jean-Pierre Benoit; Alf Lamprecht
Lipid nanocapsules for intracellular drug delivery of anticancer drugs.
Journal of nanoscience and nanotechnology 2007;7(12):4612-7.
2007: Nicolas Anton; Patrick Saulnier; Frank Boury; Françoise Foussard; Jean-Pierre Benoit; Jacques-Emile Proust
The influence of headgroup structure and fatty acyl chain saturation of phospholipids on monolayer behavior: a comparative rheological study.
Chemistry and physics of lipids 2007;150(2):167-75.
2007: Arnaud Béduneau; Patrick Saulnier; Jean-Pierre Benoit
Active targeting of brain tumors using nanocarriers.
Biomaterials 2007;28(33):4947-67.
2007: Arnaud Béduneau; Patrick Saulnier; François Hindré; Anne Clavreul; Jean-Christophe Leroux; Jean-Pierre Benoit
Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments.
Biomaterials 2007;28(33):4978-90.
2007: FRANCK LACOEUILLE; F Hindre; Frédéric Moal; Jérôme Roux; Catherine Passirani; O Couturier; P Cales; Jean-Jacques Le Jeune; Alf Lamprecht; Jean-Pierre Benoit
In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel.
International journal of pharmaceutics 2007;344(1-2):143-9.
2007: Nicolas Anton; Pascal Gayet; Jean-Pierre Benoit; Patrick Saulnier
Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion.
International journal of pharmaceutics 2007;344(1-2):44-52.
2007: Anne Pasco; Laurent Lemaire; florence franconi; Yann LeFur; Fanny Noury; Jean-Paul Saint-André; Jean-Pierre Benoit; Patrick J Cozzone; Jean-Jacques Le Jeune
Perfusional deficit and the dynamics of cerebral edemas in experimental traumatic brain injury using perfusion and diffusion-weighted magnetic resonance imaging.
Journal of neurotrauma 2007;24(8):1321-30.
2007: Nicolas Anton; Patrick Saulnier; Arnaud Béduneau; Jean-Pierre Benoit
Salting-out effect induced by temperature cycling on a water/nonionic surfactant/oil system.
The journal of physical chemistry. B 2007;111(14):3651-7.
2007: Valérie M Tatard; Laurence Sindji; Jennifer Godbee Branton; Anne Aubert-Pouëssel; Jacqueline Colleau; Jean-Pierre Benoit; Claudia Montero-Menei
Pharmacologically active microcarriers releasing glial cell line - derived neurotrophic factor: Survival and differentiation of embryonic dopaminergic neurons after grafting in hemiparkinsonian rats.
Biomaterials 2007;28(11):1978-88.
2007: P Mowat; florence franconi; Catherine Chapon; Laurent Lemaire; J Dorat; François Hindré; Jean-Pierre Benoit; Pascal Richomme; Jean-Jacques Le Jeune
Evaluating SPIO-labelled cell MR efficiency by three-dimensional quantitative T2* MRI.
NMR in biomedicine 2007;20(1):21-7.
2006: Anne Sapin; Anne Clavreul; EMMANUEL GARCION; Jean-Pierre Benoit; philippe menei
Evaluation of particulate systems supporting tumor cell fractions in a preventive vaccination against intracranial rat glioma.
Journal of neurosurgery 2006;105(5):745-52.
2006: Elvire Fournier; Catherine Passirani; Nathalie Colin; Serge Sagodira; philippe menei; Jean-Pierre Benoit; Claudia Montero-Menei
The brain tissue response to biodegradable poly(methylidene malonate 2.1.2)-based microspheres in the rat.
Biomaterials 2006;27(28):4963-74.
2006: Arnaud Béduneau; Patrick Saulnier; Nicolas Anton; François Hindré; Catherine Passirani; Holisoa Rajerison; Nicolas Noiret; Jean-Pierre Benoit
Pegylated nanocapsules produced by an organic solvent-free method: Evaluation of their stealth properties.
Pharmaceutical research 2006;23(9):2190-9.
2006: Arnaud Vonarbourg; Catherine Passirani; Patrick Saulnier; Pierre Simard; Jean-Christophe Leroux; Jean-Pierre Benoit
Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake.
Journal of biomedical materials research. Part A 2006;78(3):620-8.
2006: Arnaud Vonarbourg; Catherine Passirani; Patrick Saulnier; Jean-Pierre Benoit
Parameters influencing the stealthiness of colloidal drug delivery systems.
Biomaterials 2006;27(24):4356-73.
2006: Anne Pasco; Aram Ter Minassian; Catherine Chapon; Laurent Lemaire; florence franconi; Dana Darabi; Christine Caron; Jean-Pierre Benoit; Jean-Jacques Le Jeune
Dynamics of cerebral edema and the apparent diffusion coefficient of water changes in patients with severe traumatic brain injury. A prospective MRI study.
European radiology 2006;16(7):1501-8.
2006: frederic Lagarce; EMMANUEL GARCION; Nathalie Faisant; O Thomas; P Kanaujia; philippe menei; Jean-Pierre Benoit
Development and characterization of interleukin-18-loaded biodegradable microspheres.
International journal of pharmaceutics 2006;314(2):179-88.
2006: Stephanie Koennings; EMMANUEL GARCION; Nathalie Faisant; philippe menei; Jean-Pierre Benoit; Achim Goepferich
In vitro investigation of lipid implants as a controlled release system for interleukin-18.
International journal of pharmaceutics 2006;314(2):145-52.
2006: Nathalie Faisant; J Akiki; Florence Siepmann; Jean-Pierre Benoit; Juergen Siepmann
Effects of the type of release medium on drug release from PLGA-based microparticles: experiment and theory.
International journal of pharmaceutics 2006;314(2):189-97.
2006: Khaled Elkharraz; Nathalie Faisant; C Guse; Florence Siepmann; B Arica-Yegin; J M Oger; R Gust; Achim Goepferich; Jean-Pierre Benoit; Juergen Siepmann
Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization.
International journal of pharmaceutics 2006;314(2):127-36.
2006: Sandrine Ballot; Nicolas Noiret; François Hindré; Benoit Denizot; Etienne Garin; Holisoa Rajerison; Jean-Pierre Benoit
99mTc/188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution.
European journal of nuclear medicine and molecular imaging 2006;33(5):602-7.
2006: Anne-Magali Layre; Patrick Couvreur; Hélène Chacun; Joël Richard; Catherine Passirani; Denis Requier; Jean-Pierre Benoit; Ruxandra Gref
Novel composite core-shell nanoparticles as busulfan carriers.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):271-80.
2006: Anne Sapin; EMMANUEL GARCION; Anne Clavreul; frederic Lagarce; Jean-Pierre Benoit; philippe menei
Development of new polymer-based particulate systems for anti-glioma vaccination.
International journal of pharmaceutics 2006;309(1-2):1-5.
2005: Manuela Pereira de Oliveira; EMMANUEL GARCION; Nicolas Venisse; Jean-Pierre Benoit; William Couet; Jean-Christophe Olivier
Tissue distribution of indinavir administered as solid lipid nanocapsule formulation in mdr1a (+/+) and mdr1a (-/-) CF-1 mice.
Pharmaceutical research 2005;22(11):1898-1905.
2005: Aude Motulsky; Michel Lafleur; Anne-Claude Couffin-Hoarau; Didier Hoarau; Frank Boury; Jean-Pierre Benoit; Jean-Christophe Leroux
Characterization and biocompatibility of organogels based on L-alanine for parenteral drug delivery implants.
Biomaterials 2005;26(31):6242-53.
2005: frederic Lagarce; Nathalie Faisant; Jean-Claude Desfontis; Laurent Marescaux; Freddy Gautier; Joel Richard; philippe menei; Jean-Pierre Benoit
Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: in vitro and in vivo evaluation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;61(3):171-80.
2005: frederic Lagarce; Nathalie Faisant; Jean-Claude Desfontis; Laurent Marescaux; Freddy Gautier; Delphine Holopherne; Marie-Christine Rousselet; philippe menei; Jean-Pierre Benoit
Biopharmaceutics of intrathecal baclofen-loaded microparticles in a goat model.
International journal of pharmaceutics 2005;298(1):68-79.
2005: Etienne Garin; Benoit Denizot; Jerome Roux; Nicolas Noiret; Nicolas Lepareur; Myriam Moreau; H Mesba; J F Laurent; Jean-Yves Herry; Patrick Bourguet; Jean-Pierre Benoit; Jean-Jacques Lejeune
Description and technical pitfalls of a hepatoma model and of intra-arterial injection of radiolabelled lipiodol in the rat.
Laboratory animals 2005;39(3):314-20.
2005: Etienne Garin; Benoit Denizot; Jerome Roux; Nicolas Noiret; Nicolas Lepareur; Myriam Moreau; Abiba Mesba; Jean-François Laurent; Jean-Yves Herry; Patrick Bourguet; Jean-Pierre Benoit; Jean-Jacques Lejeune
Effect of stabilized iodized oil emulsion on experimentally induced hepatocellular carcinoma in rats.
Journal of vascular and interventional radiology : JVIR 2005;16(6):841-8.
2005: Arnaud Vonarbourg; Patrick Saulnier; Catherine Passirani; Jean-Pierre Benoit
Electrokinetic properties of noncharged lipid nanocapsules: influence of the dipolar distribution at the interface.
Electrophoresis 2005;26(11):2066-75.
2005: Valérie M Tatard; Marie-Claire Venier-Julienne; Patrick Saulnier; E Prechter; Jean-Pierre Benoit; philippe menei; Claudia Montero-Menei
Pharmacologically active microcarriers: a tool for cell therapy.
Biomaterials 2005;26(17):3727-37.
2005: frederic Lagarce; Pascal Renaud; Nathalie Faisant; Guillaume Nicolas; Annie Cailleux; Joel Richard; philippe menei; Jean-Pierre Benoit
Baclofen-loaded microspheres: preparation and efficacy testing in a new rabbit model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;59(3):449-59.
2005: philippe menei; Claudia Montero-Menei; Marie-Claire Venier; Jean-Pierre Benoit
Drug delivery into the brain using poly(lactide-co-glycolide) microspheres.
Expert opinion on drug delivery 2005;2(2):363-76.
2005: Valérie M Tatard; philippe menei; Jean-Pierre Benoit; Claudia Montero-Menei
Combining polymeric devices and stem cells for the treatment of neurological disorders: a promising therapeutic approach.
Current drug targets 2005;6(1):81-96.
2005: philippe menei; Laurent Capelle; Jacques Guyotat; Stéphane Fuentes; Richard Assaker; Benoit Bataille; Patrick François; Didier Dorwling-Carter; Philippe Paquis; Luc Bauchet; Fabrice Parker; Jean Sabatier; Nathalie Faisant; Jean-Pierre Benoit
Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of malignant glioma: a randomized phase II trial.
Neurosurgery 2005;56(2):242-8; discussion 242-8.
2005: Charlotte Andrieu-Soler; Anne Aubert-Pouëssel; Marc Doat; Serge Picaud; Mounia Halhal; Manuel Simonutti; Marie-Claire Venier-Julienne; Jean-Pierre Benoit; Francine Behar-Cohen
Intravitreous injection of PLGA microspheres encapsulating GDNF promotes the survival of photoreceptors in the rd1/rd1 mouse.
Molecular vision 2005;11():1002-11.
2004: Etienne Garin; Benoit Denizot; Nicolas Noiret; Nicolas Lepareur; Jerome Roux; Myriam Moreau; Jean-Yves Herry; Patrick Bourguet; Jean-Pierre Benoit; Jean-Jacques Lejeune
188Re-SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma.
Nuclear medicine communications 2004;25(10):1007-13.
2004: Valérie-Gaëlle Roullin; Martine Mege; Laurent Lemaire; Jean-Pierre Cueyssac; Marie-Claire Venier-Julienne; philippe menei; Erick Gamelin; Jean-Pierre Benoit
Influence of 5-fluorouracil-loaded microsphere formulation on efficient rat glioma radiosensitization.
Pharmaceutical research 2004;21(9):1558-63.
2004: Alf Lamprecht; Jean Louis Saumet; Jérôme Roux; Jean-Pierre Benoit
Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment.
International journal of pharmaceutics 2004;278(2):407-14.
2004: Christophe Jollivet; Claudia Montero-Menei; Marie-Claire Venier-Julienne; Anne Sapin; Jean-Pierre Benoit; philippe menei
Striatal tyrosine hydroxylase immunoreactive neurons are induced by L-dihydroxyphenylalanine and nerve growth factor treatment in 6-hydroxydopamine lesioned rats.
Neuroscience letters 2004;362(2):79-82.
2004: Juergen Siepmann; Nathalie Faisant; J Akiki; J Richard; Jean-Pierre Benoit
Effect of the size of biodegradable microparticles on drug release: experiment and theory.
Journal of controlled release : official journal of the Controlled Release Society 2004;96(1):123-34.
2004: Anne Aubert-Pouëssel; Marie-Claire Venier-Julienne; Anne Clavreul; Michelle Sergent; Christophe Jollivet; Claudia Montero-Menei; EMMANUEL GARCION; David C Bibby; philippe menei; Jean-Pierre Benoit
In vitro study of GDNF release from biodegradable PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):463-75.
2004: Elvire Fournier; Catherine Passirani; Nathalie Colin; Pascal Breton; Serge Sagodira; Jean-Pierre Benoit
Development of novel 5-FU-loaded poly(methylidene malonate 2.1.2)-based microspheres for the treatment of brain cancers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;57(2):189-97.
2004: Christophe Jollivet; Anne Aubert-Pouessel; Anne Clavreul; Marie-Claire Venier-Julienne; Claudia Montero-Menei; Jean-Pierre Benoit; philippe menei
Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease.
Neuroscience letters 2004;356(3):207-10.
2004: Emmanuelle Roux; Catherine Passirani; Stefanie Scheffold; Jean-Pierre Benoit; Jean-Christophe Leroux
Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2004;94(2-3):447-51.
2004: T Rizk; Claudia Montero-Menei; Christophe Jollivet; Jean-Pierre Benoit; philippe menei
Pitfalls in the detection of lipid vectors in neural cell culture and in brain tissue.
Journal of biomedical materials research. Part A 2004;68(2):360-4.
2004: Christophe Jollivet; Anne Aubert-Pouessel; Anne Clavreul; Marie-Claire Venier-Julienne; Séverine Remy; Claudia Montero-Menei; Jean-Pierre Benoit; philippe menei
Striatal implantation of GDNF releasing biodegradable microspheres promotes recovery of motor function in a partial model of Parkinson's disease.
Biomaterials 2004;25(5):933-42.
2004: philippe menei; Eric Jadaud; Nathalie Faisant; Michèle Boisdron-Celle; Sophie Michalak; Dominique Fournier; Manuel Delhaye; Jean-Pierre Benoit
Stereotaxic implantation of 5-fluorouracil-releasing microspheres in malignant glioma.
Cancer 2004;100(2):405-10.
2004: Valérie M Tatard; Marie-Claire Venier-Julienne; Jean-Pierre Benoit; philippe menei; Claudia Montero-Menei
In vivo evaluation of pharmacologically active microcarriers releasing nerve growth factor and conveying PC12 cells.
Cell transplantation 2004;13(5):573-83.
2003: Elvire Fournier; Catherine Passirani; Arnaud Vonarbourg; Laurent Lemaire; Nathalie Colin; Serge Sagodira; philippe menei; Jean-Pierre Benoit
Therapeutic efficacy study of novel 5-FU-loaded PMM 2.1.2-based microspheres on C6 glioma.
International journal of pharmaceutics 2003;268(1-2):31-5.
2003: Béatrice Heurtault; Patrick Saulnier; Brigitte Pech; Jacques-Emile Proust; Jean-Pierre Benoit
Physico-chemical stability of colloidal lipid particles.
Biomaterials 2003;24(23):4283-300.
2003: Nathalie Faisant; Juergen Siepmann; Joel Richard; Jean-Pierre Benoit
Mathematical modeling of drug release from bioerodible microparticles: effect of gamma-irradiation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2003;56(2):271-9.
2003: Elvire Fournier; Catherine Passirani; Claudia Montero-Menei; Jean-Pierre Benoit
Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility.
Biomaterials 2003;24(19):3311-31.
2003: Elvire Fournier; Catherine Passirani; Claudia Montero-Menei; Nathalie Colin; Pascal Breton; Serge Sagodira; philippe menei; Jean-Pierre Benoit
Therapeutic effectiveness of novel 5-fluorouracil-loaded poly(methylidene malonate 2.1.2)-based microspheres on F98 glioma-bearing rats.
Cancer 2003;97(11):2822-9.
2003: Alf Lamprecht; Jean-Pierre Benoit
Simple liquid-chromatographic method for Nile Red quantification in cell culture in spite of photobleaching.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;787(2):415-9.
2003: Valérie-Gaëlle Roullin; Laurent Lemaire; Marie-Claire Venier-Julienne; Nathalie Faisant; florence franconi; Jean-Pierre Benoit
Release kinetics of 5-fluorouracil-loaded microspheres on an experimental rat glioma.
Anticancer research 2003;23(1A):21-5.
2003: I Ribeiro Dos Santos; J Richard; C Thies; Brigitte Pech; Jean-Pierre Benoit
A supercritical fluid-based coating technology. 3: preparation and characterization of bovine serum albumin particles coated with lipids.
Journal of microencapsulation 2003;20(1):110-28.
2003: I Ribeiro Dos Santos; C Thies; J Richard; D Le Meurlay; V Gajan; V VandeVelde; Jean-Pierre Benoit
A supercritical fluid-based coating technology. 2: solubility considerations.
Journal of microencapsulation 2003;20(1):97-109.
2003: C Thies; I Ribeiro Dos Santos; J Richard; V VandeVelde; H Rolland; Jean-Pierre Benoit
A supercritical fluid-based coating technology 1: process considerations.
Journal of microencapsulation 2003;20(1):87-96.
2002: Juergen Siepmann; Nathalie Faisant; Jean-Pierre Benoit
A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations.
Pharmaceutical research 2002;19(12):1885-93.
2002: Alf Lamprecht; Yves Bouligand; Jean-Pierre Benoit
New lipid nanocapsules exhibit sustained release properties for amiodarone.
Journal of controlled release : official journal of the Controlled Release Society 2002;84(1-2):59-68.
2002: I Ribeiro Dos Santos; J Richard; Brigitte Pech; C Thies; Jean-Pierre Benoit
Microencapsulation of protein particles within lipids using a novel supercritical fluid process.
International journal of pharmaceutics 2002;242(1-2):69-78.
2002: Alf Lamprecht; Patrick Saulnier; Frank Boury; Catherine Passirani; Jacques-Emile Proust; Jean-Pierre Benoit
A quantitative method for the determination of amphiphilic drug release kinetics from nanoparticles using a Langmuir balance.
Analytical chemistry 2002;74(14):3416-20.
2002: Béatrice Heurtault; Patrick Saulnier; Brigitte Pech; Jacques-Emile Proust; Jean-Pierre Benoit
A novel phase inversion-based process for the preparation of lipid nanocarriers.
Pharmaceutical research 2002;19(6):875-80.
2002: Christelle Gouhier; Sylvie Chalon; Anne Aubert-Pouessel; Marie-Claire Venier-Julienne; Christophe Jollivet; Jean-Pierre Benoit; Denis Guilloteau
Protection of dopaminergic nigrostriatal afferents by GDNF delivered by microspheres in a rodent model of Parkinson's disease.
Synapse (New York, N.Y.) 2002;44(3):124-31.
2002: Nathalie Faisant; Juergen Siepmann; Jean-Pierre Benoit
PLGA-based microparticles: elucidation of mechanisms and a new, simple mathematical model quantifying drug release.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(4):355-66.
2002: Valérie-Gaëlle Roullin; Jean-Robert Deverre; Laurent Lemaire; François Hindré; Marie-Claire Venier-Julienne; Raymond Vienet; Jean-Pierre Benoit
Anti-cancer drug diffusion within living rat brain tissue: an experimental study using [3H](6)-5-fluorouracil-loaded PLGA microspheres.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2002;53(3):293-9.
2002: Manuela Igartua; Patrick Saulnier; Béatrice Heurtault; Brigitte Pech; Jacques-Emile Proust; José Luis Pedraz; Jean-Pierre Benoit
Development and characterization of solid lipid nanoparticles loaded with magnetite.
International journal of pharmaceutics 2002;233(1-2):149-57.
2001: Laurent Lemaire; Valérie-Gaëlle Roullin; florence franconi; Marie-Claire Venier-Julienne; philippe menei; Pierre Jallet; Jean-Jacques Le Jeune; Jean-Pierre Benoit
Therapeutic efficacy of 5-fluorouracil-loaded microspheres on rat glioma: a magnetic resonance imaging study.
NMR in biomedicine 2001;14(6):360-6.
2001: J Veziers; M Lesourd; Christophe Jollivet; Claudia Montero-Menei; Jean-Pierre Benoit; philippe menei
Analysis of brain biocompatibility of drug-releasing biodegradable microspheres by scanning and transmission electron microscopy.
Journal of neurosurgery 2001;95(3):489-94.
2001: A Gèze; Marie-Claire Venier-Julienne; J Cottin; Nathalie Faisant; Jean-Pierre Benoit
PLGA microsphere bioburden evaluation for radiosterilization dose selection.
Journal of microencapsulation 2001;18(5):627-36.
2000: JM Péan; philippe menei; O Morel; Claudia Montero-Menei; Jean-Pierre Benoit
Intraseptal implantation of NGF-releasing microspheres promote the survival of axotomized cholinergic neurons.
Biomaterials 2000;21(20):2097-101.
2000: Jean-Pierre Benoit; Nathalie Faisant; Marie-Claire Venier-Julienne; philippe menei
Development of microspheres for neurological disorders: from basics to clinical applications.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):285-96.
1999: JM Péan; Frank Boury; Marie-Claire Venier-Julienne; philippe menei; Jacques-Emile Proust; Jean-Pierre Benoit
Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?
Pharmaceutical research 1999;16(8):1294-9.
1999: philippe menei; M C Venier; E Gamelin; J P Saint-André; G Hayek; Eric Jadaud; Dominique Fournier; Ph Mercier; G Guy; Jean-Pierre Benoit
Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: a pilot study.
Cancer 1999;86(2):325-30.
1999: A Geze; Marie-Claire Venier-Julienne; Patrick Saulnier; Pascale Varlet; Catherine Daumas-Duport; P Devauchelle; Jean-Pierre Benoit
Modulated release of IdUrd from poly (D,L-lactide-co-glycolide) microspheres by addition of poly (D,L-lactide) oligomers.
Journal of controlled release : official journal of the Controlled Release Society 1999;58(3):311-22.
1999: C Amiet-Charpentier; P Gadille; Jean-Pierre Benoit
Rhizobacteria microencapsulation: properties of microparticles obtained by spray-drying.
Journal of microencapsulation 1999;16(2):215-29.
1999: A Gèze; Marie-Claire Venier-Julienne; D Mathieu; R Filmon; Roger Phan Tan Luu; Jean-Pierre Benoit
Development of 5-iodo-2'-deoxyuridine milling process to reduce initial burst release from PLGA microparticles.
International journal of pharmaceutics 1999;178(2):257-68.
1999: O Cruaud; S Benita; Jean-Pierre Benoit
The characterization and release kinetics evaluation of baclofen microspheres designed for intrathecal injection.
International journal of pharmaceutics 1999;177(2):247-57.
1999: A Geze; Igor Chourpa; Frank Boury; Jean-Pierre Benoit; Pierre Dubois
Direct qualitative and quantitative characterization of a radiosensitizer, 5-iodo-2'-deoxyuridine within biodegradable polymeric microspheres by FT-Raman spectroscopy.
The Analyst 1999;124(1):37-42.
1998: JM Péan; Marie-Claire Venier-Julienne; Frank Boury; philippe menei; Benoit Denizot; Jean-Pierre Benoit
NGF release from poly(D,L-lactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):175-87.
1998: C Amiet-Charpentier; P Gadille; B Digat; Jean-Pierre Benoit
Microencapsulation of rhizobacteria by spray-drying: formulation and survival studies.
Journal of microencapsulation 1998;15(5):639-59.
1998: T Painbeni; Marie-Claire Venier-Julienne; Jean-Pierre Benoit
Internal morphology of poly(D,L-lactide-co-glycolide) BCNU-loaded microspheres. Influence on drug stability.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1998;45(1):31-9.
1997: Brigitte Pech; Jacques-Emile Proust; Y Bouligand; Jean-Pierre Benoit
Tensioactivity and supramolecular organization of the palmitoyl prodrug of timolol.
Pharmaceutical research 1997;14(1):37-41.
1997: Frank Boury; H Marchais; Jean-Pierre Benoit; Jacques-Emile Proust
Surface characterization of poly(alpha-hydroxy acid) microspheres prepared by a solvent evaporation/extraction process.
Biomaterials 1997;18(2):125-36.
1996: Christiane Damgé; Marc Aprahamian; H Marchais; Jean-Pierre Benoit; Michel Pinget
Intestinal absorption of PLAGA microspheres in the rat.
Journal of anatomy 1996;189 ( Pt 3)():491-501.
1996: philippe menei; M Boisdron-Celle; A Croué; G Guy; Jean-Pierre Benoit
Effect of stereotactic implantation of biodegradable 5-fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats.
Neurosurgery 1996;39(1):117-23; discussion 123-4.
1996: A I Torres; M Boisdron-Celle; Jean-Pierre Benoit
Formulation of BCNU-loaded microspheres: influence of drug stability and solubility on the design of the microencapsulation procedure.
Journal of microencapsulation 1996;13(1):41-51.
1995: M Boisdron-Celle; philippe menei; Jean-Pierre Benoit
Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers.
The Journal of pharmacy and pharmacology 1995;47(2):108-14.
1995: Marie-Claire Venier-Julienne; I Vouldoukis; L Monjour; Jean-Pierre Benoit
In vitro study of the anti-leishmanial activity of biodegradable nanoparticles.
Journal of drug targeting 1995;3(1):23-9.
1994: philippe menei; A Croué; V Daniel; A Pouplard-Barthelaix; Jean-Pierre Benoit
Fate and biocompatibility of three types of microspheres implanted into the brain.
Journal of biomedical materials research 1994;28(9):1079-85.
1994: philippe menei; Jean-Pierre Benoit; M Boisdron-Celle; Dominique Fournier; Ph Mercier; G Guy
Drug targeting into the central nervous system by stereotactic implantation of biodegradable microspheres.
Neurosurgery 1994;34(6):1058-64; discussion 1064.
1993: philippe menei; V Daniel; Claudia Montero-Menei; M Brouillard; A Pouplard-Barthelaix; Jean-Pierre Benoit
Biodegradation and brain tissue reaction to poly(D,L-lactide-co-glycolide) microspheres.
Biomaterials 1993;14(6):470-8.
1993: B Pech; Patrizia Chetoni; M Fabrizio Saettone; O Duval; Jean-Pierre Benoit
Preliminary evaluation of a series of amphiphilic timolol prodrugs: possible evidence for transscleral absorption.
Journal of ocular pharmacology 1993;9(2):141-50.
1992: J R Deverre; Philippe LOISEAU; F Puisieux; P Gayral; Yves Letourneux; P Couvreur; Jean-Pierre Benoit
Synthesis of the orally macrofilaricidal and stable glycerolipidic prodrug of melphalan, 1,3-dipalmitoyl-2-(4'(bis(2''-chloroethyl)amino)phenylalaninoyl)gl ycerol.
Arzneimittel-Forschung 1992;42(9):1153-6.
1992: J R Deverre; Philippe LOISEAU; P Gayral; Yves Letourneux; P Couvreur; Jean-Pierre Benoit
In vitro and in vivo evaluation of macrofilaricidal activity of GABA and 1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol HCl: a diglyceride prodrug.
Pharmaceutica acta Helvetiae 1992;67(12):349-52.
1991: V Rosilio; Jean-Pierre Benoit; M Deyme; C Thies; G Madelmont
A physicochemical study of the morphology of progesterone-loaded microspheres fabricated from poly(D,L-lactide-co-glycolide).
Journal of biomedical materials research 1991;25(5):667-82.
1989: J R Deverre; Philippe LOISEAU; P Couvreur; Yves Letourneux; P Gayral; Jean-Pierre Benoit
In-vitro evaluation of filaricidal activity of GABA and 1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol HCl: a diglyceride prodrug.
The Journal of pharmacy and pharmacology 1989;41(3):191-3.
1988: A Sawaya; R Fickat; Jean-Pierre Benoit; F Puisieux; S Benita
Ion-exchange albumin microcapsules of doxorubicin: an in vitro release kinetic evaluation.
Journal of microencapsulation 1988;5(3):255-67.
1987: A Sawaya; Jean-Pierre Benoit; S Benita
Binding mechanism of doxorubicin in ion-exchange albumin microcapsules.
Journal of pharmaceutical sciences 1987;76(6):475-80.
1987: A Sawaya; M Deyme; Jean-Pierre Benoit
Calcium and thiocyanate interactions with crosslinked albumin microcapsules: influence of the reticulation rate.
Biomaterials 1987;8(3):211-6.
1986: S Benita; O Zouai; Jean-Pierre Benoit
5-Fluorouracil:carnauba wax microspheres for chemoembolization: an in vitro evaluation.
Journal of pharmaceutical sciences 1986;75(9):847-51.
1986: M Cavalier; Jean-Pierre Benoit; C Thies
The formation and characterization of hydrocortisone-loaded poly((+/-)-lactide) microspheres.
The Journal of pharmacy and pharmacology 1986;38(4):249-53.
1984: S Benita; Jean-Pierre Benoit; F Puisieux; C Thies
Characterization of drug-loaded poly(d,l-lactide) microspheres.
Journal of pharmaceutical sciences 1984;73(12):1721-4.