Bharat Aggarwal

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Tharakan Sheeja T; Inamoto Teruo; Sung Bokyung; Aggarwal Bharat B; Kamat Ashish M
Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
Kunnumakkara Ajaikumar B; Diagaradjane Parmeswaran; Anand Preetha; Kuzhuvelil Harikumar B; Deorukhkar Amit; Gelovani Juri; Guha Sushovan; Krishnan Sunil; Aggarwal Bharat B
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
Aggarwal Bharat B; Danda Divya; Gupta Shan; Gehlot Prashasnika
Models for prevention and treatment of cancer: problems vs promises.

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All Publications

2010: Tharakan Sheeja T; Inamoto Teruo; Sung Bokyung; Aggarwal Bharat B; Kamat Ashish M
Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
Biochemical pharmacology 2010;79(2):218-28.
2009: Kunnumakkara Ajaikumar B; Diagaradjane Parmeswaran; Anand Preetha; Kuzhuvelil Harikumar B; Deorukhkar Amit; Gelovani Juri; Guha Sushovan; Krishnan Sunil; Aggarwal Bharat B
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
International journal of cancer. Journal international du cancer 2009;125(9):2187-97.
2009: Aggarwal Bharat B; Danda Divya; Gupta Shan; Gehlot Prashasnika
Models for prevention and treatment of cancer: problems vs promises.
Biochemical pharmacology 2009;78(9):1083-94.
2009: Pervaiz Shazib; Holme Andrea Lisa; Aggarwal Bharat B; Anekonda Thimmappa S; Baur Joseph A; Gojkovic-Bukarica Ljiljana; Ragione Fulvio Della; Kim Arianna L; Pirola Luciano; Saiko Philipp
Resveratrol: its biologic targets and functional activity.
Antioxidants & redox signaling 2009;11(11):2851-97.
2009: Sandur Santosh K; Deorukhkar Amit; Pandey Manoj K; Pabón Ana María; Shentu Shujun; Guha Sushovan; Aggarwal Bharat B; Krishnan Sunil
Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.
International journal of radiation oncology, biology, physics 2009;75(2):534-42.
2009: Ravindran Jayaraj; Prasad Sahdeo; Aggarwal Bharat B
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
The AAPS journal 2009;11(3):495-510.
2009: Aggarwal Bharat B; Kunnumakkara Ajaikumar B; Harikumar Kuzhuvelil B; Gupta Shan R; Tharakan Sheeja T; Koca Cemile; Dey Sanjit; Sung Bokyung
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.
Annals of the New York Academy of Sciences 2009;1171():59-76.
2009: Aggarwal Bharat B
Inflammation, a silent killer in cancer is not so silent!
Current opinion in pharmacology 2009;9(4):347-50.
2009: Aggarwal Bharat B; Gehlot Prashasnika
Inflammation and cancer: how friendly is the relationship for cancer patients?
Current opinion in pharmacology 2009;9(4):351-69.
2009: Yodkeeree Supachai; Sung Bokyung; Limtrakul Pornngarm; Aggarwal Bharat B
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.
Cancer research 2009;69(16):6581-9.
2009: Aggarwal Bharat B; Van Kuiken Michelle E; Iyer Laxmi H; Harikumar Kuzhuvelil B; Sung Bokyung
Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.
Experimental biology and medicine (Maywood, N.J.) 2009;234(8):825-49.
2009: Pang Xiufeng; Yi Zhengfang; Zhang Xiaoli; Sung Bokyung; Qu Weijing; Lian Xiaoyuan; Aggarwal Bharat B; Liu Mingyao
Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
Cancer research 2009;69(14):5893-900.
2009: Mulabagal Vanisree; Subbaraju Gottumukkala V; Rao Chirravuri V; Sivaramakrishna Chillara; Dewitt David L; Holmes Daniel; Sung Bokyung; Aggarwal Bharat B; Tsay Hsin-Sheng; Nair Muraleedharan G
Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation.
Phytotherapy research : PTR 2009;23(7):987-92.
2009: Matsuo Yoichi; Campbell Paul M; Brekken Rolf A; Sung Bokyung; Ouellette Michel M; Fleming Jason B; Aggarwal Bharat B; Der Channing J; Guha Sushovan
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Molecular cancer research : MCR 2009;7(6):799-808.
2009: Sung Bokyung; Kunnumakkara Ajaikumar B; Sethi Gautam; Anand Preetha; Guha Sushovan; Aggarwal Bharat B
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Molecular cancer therapeutics 2009;8(4):959-70.
2009: Muralimanoharan Sri Balasubashini; Kunnumakkara A B; Shylesh Bhaskaran; Kulkarni Kaustubh H; Haiyan Xu; Ming Hu; Aggarwal Bharat B; Rita Ghosh; Kumar Addanki P
Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.
The Prostate 2009;69(5):494-504.
2009: Pandey Manoj K; Sung Bokyung; Ahn Kwang Seok; Aggarwal Bharat B
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
Molecular pharmacology 2009;75(3):525-33.
2009: Sung Bokyung; Murakami Akira; Oyajobi Babatunde O; Aggarwal Bharat B
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice.
Cancer research 2009;69(4):1477-84.
2009: Aggarwal Bharat B; Sung Bokyung
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Trends in pharmacological sciences 2009;30(2):85-94.
2009: Reuter Simone; Schnekenburger Michael; Cristofanon Silvia; Buck Isabelle; Teiten Marie-Hélène; Daubeuf Sandrine; Eifes Serge; Dicato Mario; Aggarwal Bharat B; Visvikis Athanase; Diederich Marc
Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.
Biochemical pharmacology 2009;77(3):397-411.
2009: Harikumar Kuzhuvelil B; Kunnumakkara Ajaikumar B; Ahn Kwang S; Anand Preetha; Krishnan Sunil; Guha Sushovan; Aggarwal Bharat B
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Blood 2009;113(9):2003-13.
2009: Aggarwal Bharat B; Vijayalekshmi R V; Sung Bokyung
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):425-30.
2009: Kunnumakkara Ajaikumar B; Nair Asha S; Sung Bokyung; Pandey Manoj K; Aggarwal Bharat B
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
Molecular cancer research : MCR 2009;7(1):118-28.
2009: Shakibaei Mehdi; Harikumar Kuzhuvelil B; Aggarwal Bharat B
Resveratrol addiction: to die or not to die.
Molecular nutrition & food research 2009;53(1):115-28.
2009: Aggarwal Bharat B; Harikumar Kuzhuvelil B
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
The international journal of biochemistry & cell biology 2009;41(1):40-59.
2009: Sethi Gautam; Sung Bokyung; Aggarwal Bharat B
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Advances in experimental medicine and biology 2009;647():207-15.
2009: Sethi Gautam; Sung Bokyung; Kunnumakkara Ajaikumar B; Aggarwal Bharat B
Targeting TNF for Treatment of Cancer and Autoimmunity.
Advances in experimental medicine and biology 2009;647():37-51.
2009: Gupta Vishal; Aseh Abraham; Ríos Carmen N; Aggarwal Bharat B; Mathur Anshu B
Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy.
International journal of nanomedicine 2009;4():115-22.
2009: Ralhan Ranju; Pandey Manoj K; Aggarwal Bharat B
Nuclear factor-kappa B links carcinogenic and chemopreventive agents.
Frontiers in bioscience (scholar edition) 2009;1():45-60.
2008: Anand Preetha; Thomas Sherin G; Kunnumakkara Ajaikumar B; Sundaram Chitra; Harikumar Kuzhuvelil B; Sung Bokyung; Tharakan Sheeja T; Misra Krishna; Priyadarsini Indira K; Rajasekharan Kallikat N; Aggarwal Bharat B
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Biochemical pharmacology 2008;76(11):1590-611.
2008: Reuter Simone; Eifes Serge; Dicato Mario; Aggarwal Bharat B; Diederich Marc
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.
Biochemical pharmacology 2008;76(11):1340-51.
2008: Sethi Gautam; Ahn Kwang Seok; Sung Bokyung; Kunnumakkara Ajaikumar B; Chaturvedi Madan M; Aggarwal Bharat B
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Shishodia Shishir; Harikumar Kuzhuvelil B; Dass Suchismita; Ramawat Krishan G; Aggarwal Bharat B
The guggul for chronic diseases: ancient medicine, modern targets.
Anticancer research 2008;28(6A):3647-64.
2008: Sung Bokyung; Jhurani Sonia; Ahn Kwang Seok; Mastuo Yoichi; Yi Tingfang; Guha Sushovan; Liu Mingyao; Aggarwal Bharat B
Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells.
Cancer research 2008;68(21):8938-44.
2008: Anand Preetha; Kunnumakkara Ajaikumar B; Harikumar Kuzhuvelil B; Ahn Kwang Seok; Badmaev Vladimir; Aggarwal Bharat B
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.
Cancer research 2008;68(21):8861-70.
2008: Kunnumakkara Ajaikumar B; Ichikawa Haruyo; Anand Preetha; Mohankumar Chiramel J; Hema Padmanabhan S; Nair Mangalam S; Aggarwal Bharat B
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Molecular cancer therapeutics 2008;7(10):3306-17.
2008: Ahn Kwang Seok; Sethi Gautam; Chaturvedi Madan M; Aggarwal Bharat B
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2008;123(8):1733-40.
2008: Aggarwal Bharat B; Kunnumakkara Ajaikumar B; Harikumar Kuzhuvelil B; Tharakan Sheeja T; Sung Bokyung; Anand Preetha
Potential of spice-derived phytochemicals for cancer prevention.
Planta medica 2008;74(13):1560-9.
2008: Aggarwal Bharat B
The past, present and future of multi-targeted cancer treatment "naturally": food for thought.
Cancer letters 2008;269(2):187-8.
2008: Kunnumakkara Ajaikumar B; Anand Preetha; Aggarwal Bharat B
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Cancer letters 2008;269(2):199-225.
2008: Aggarwal Bharat B
Prostate cancer and curcumin: add spice to your life.
Cancer biology & therapy 2008;7(9):1436-40.
2008: Anand Preetha; Kunnumakkara Ajaikumar B; Sundaram Chitra; Harikumar Kuzhuvelil B; Tharakan Sheeja T; Lai Oiki S; Sung Bokyung; Aggarwal Bharat B
Cancer is a preventable disease that requires major lifestyle changes.
Pharmaceutical research 2008;25(9):2097-116.
2008: Goel Ajay; Jhurani Sonia; Aggarwal Bharat B
Multi-targeted therapy by curcumin: how spicy is it?
Molecular nutrition & food research 2008;52(9):1010-30.
2008: Tong Zhimin; Kunnumakkara Ajaikumar B; Wang Huamin; Matsuo Yoichi; Diagaradjane Parmeswaran; Harikumar Kuzhuvelil B; Ramachandran Vijaya; Sung Bokyung; Chakraborty Arup; Bresalier Robert S; Logsdon Craig; Aggarwal Bharat B; Krishnan Sunil; Guha Sushovan
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
Cancer research 2008;68(15):6100-8.
2008: Anand Preetha; Sundaram Chitra; Jhurani Sonia; Kunnumakkara Ajaikumar B; Aggarwal Bharat B
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Cancer letters 2008;267(1):133-64.
2008: Yi Tingfang; Cho Sung-Gook; Yi Zhengfang; Pang Xiufeng; Rodriguez Melissa; Wang Ying; Sethi Gautam; Aggarwal Bharat B; Liu Mingyao
Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways.
Molecular cancer therapeutics 2008;7(7):1789-96.
2008: Dhillon Navneet; Aggarwal Bharat B; Newman Robert A; Wolff Robert A; Kunnumakkara Ajaikumar B; Abbruzzese James L; Ng Chaan S; Badmaev Vladimir; Kurzrock Razelle
Phase II trial of curcumin in patients with advanced pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4491-9.
2008: Pandey Manoj K; Sung Bokyung; Kunnumakkara Ajaikumar B; Sethi Gautam; Chaturvedi Madan M; Aggarwal Bharat B
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Iyer Chandra; Kosters Astrid; Sethi Gautam; Kunnumakkara Ajaikumar B; Aggarwal Bharat B; Versalovic James
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
Cellular microbiology 2008;10(7):1442-52.
2008: Sethi Gautam; Ahn Kwang Seok; Aggarwal Bharat B
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.
Molecular cancer research : MCR 2008;6(6):1059-70.
2008: Sethi Gautam; Ahn Kwang Seok; Sung Bokyung; Aggarwal Bharat B
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Molecular cancer therapeutics 2008;7(6):1604-14.
2008: Ahn Kwang Seok; Sethi Gautam; Sung Bokyung; Goel Ajay; Ralhan Ranju; Aggarwal Bharat B
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Cancer research 2008;68(11):4406-15.
2008: Sung Bokyung; Pandey Manoj K; Ahn Kwang Seok; Yi Tingfang; Chaturvedi Madan M; Liu Mingyao; Aggarwal Bharat B
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.
Blood 2008;111(10):4880-91.
2008: Takada Yasunari; Sethi Gautam; Sung Bokyung; Aggarwal Bharat B
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Molecular pharmacology 2008;73(5):1549-57.
2008: Harikumar Kuzhuvelil B; Aggarwal Bharat B
Resveratrol: a multitargeted agent for age-associated chronic diseases.
Cell cycle (Georgetown, Tex.) 2008;7(8):1020-35.
2008: Verma Amit; Guha Sushovan; Diagaradjane Parmeswaran; Kunnumakkara Ajaikumar B; Sanguino Angela M; Lopez-Berestein Gabriel; Sood Anil K; Aggarwal Bharat B; Krishnan Sunil; Gelovani Juri G; Mehta Kapil
Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2476-83.
2008: Kunnumakkara Ajaikumar B; Diagaradjane Parmeswaran; Guha Sushovan; Deorukhkar Amit; Shentu Shujun; Aggarwal Bharat B; Krishnan Sunil
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2128-36.
2008: Yi Tingfang; Yi Zhengfang; Cho Sung-Gook; Luo Jian; Pandey Manoj K; Aggarwal Bharat B; Liu Mingyao
Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.
Cancer research 2008;68(6):1843-50.
2008: Herbein Georges; Varin Audrey; Larbi Anis; Fortin Carl; Mahlknecht Ulrich; Fulop Tamas; Aggarwal Bharat B
Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages.
Current HIV research 2008;6(2):117-29.
2008: Ahn Kwang Seok; Sethi Gautam; Aggarwal Bharat B
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.
Biochemical pharmacology 2008;75(4):907-13.
2008: Goel Ajay; Kunnumakkara Ajaikumar B; Aggarwal Bharat B
Curcumin as "Curecumin": from kitchen to clinic.
Biochemical pharmacology 2008;75(4):787-809.
2008: Sung Bokyung; Pandey Manoj K; Nakajima Yuki; Nishida Hiroshi; Konishi Tetsuya; Chaturvedi Madan M; Aggarwal Bharat B
Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.
Molecular cancer therapeutics 2008;7(1):191-201.
2008: Sethi Gautam; Sung Bokyung; Aggarwal Bharat B
Nuclear factor-kappaB activation: from bench to bedside.
Experimental biology and medicine (Maywood, N.J.) 2008;233(1):21-31.
2008: Shibata Hiroko; Yoshioka Yasuo; Ohkawa Akiko; Minowa Kyoko; Mukai Yohei; Abe Yasuhiro; Taniai Madoka; Nomura Tetsuya; Kayamuro Hiroyuki; Nabeshi Hiromi; Sugita Toshiki; Imai Sunao; Nagano Kazuya; Yoshikawa Tomoaki; Fujita Takuya; Nakagawa Shinsaku; Yamamoto Akira; Ohta Tsunetaka; Hayakawa Takao; Mayumi Tadanori; Vandenabeele Peter; Aggarwal Bharat B; Nakamura Teruya; Yamagata Yuriko; Tsunoda Shin-ichi; Kamada Haruhiko; Tsutsumi Yasuo
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
The Journal of biological chemistry 2008;283(2):998-1007.
2008: Sethi Gautam; Sung Bokyung; Aggarwal Bharat B
TNF: a master switch for inflammation to cancer.
Frontiers in bioscience : a journal and virtual library 2008;13():5094-107.
2007: Ahn Kwang Seok; Sethi Gautam; Aggarwal Bharat B
Nuclear factor-kappa B: from clone to clinic.
Current molecular medicine 2007;7(7):619-37.
2007: Anand Preetha; Kunnumakkara Ajaikumar B; Newman Robert A; Aggarwal Bharat B
Bioavailability of curcumin: problems and promises.
Molecular pharmaceutics 2007;4(6):807-18.
2007: Deorukhkar Amit; Krishnan Sunil; Sethi Gautam; Aggarwal Bharat B
Back to basics: how natural products can provide the basis for new therapeutics.
Expert opinion on investigational drugs 2007;16(11):1753-73.
2007: Pandey Manoj K; Sung Bokyung; Ahn Kwang Seok; Kunnumakkara Ajaikumar B; Chaturvedi Madan M; Aggarwal Bharat B
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Sethi G; Ahn K S; Chaturvedi M M; Aggarwal B B
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Oncogene 2007;26(52):7324-32.
2007: von Holzen Urs; Pataer Abujiang; Raju Uma; Bocangel Dora; Vorburger Stephan A; Liu Yanna; Lu Xiaolin; Roth Jack A; Aggarwal Bharat B; Barber Glen N; Keyomarsi Khandan; Hunt Kelly K; Swisher Stephen G
The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6032-9.
2007: Ahn Kwang Seok; Gong Xing; Sethi Gautam; Chaturvedi Madan M; Jaiswal Anil K; Aggarwal Bharat B
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Cancer research 2007;67(20):10004-11.
2007: Takada Yasunari; Sung Bokyung; Sethi Gautam; Chaturvedi Madan M; Aggarwal Bharat B
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
Biochemical pharmacology 2007;74(7):1057-64.
2007: Aggarwal Bharat B; Sethi Gautam; Baladandayuthapani Veera; Krishnan Sunil; Shishodia Shishir
Targeting cell signaling pathways for drug discovery: an old lock needs a new key.
Journal of cellular biochemistry 2007;102(3):580-92.
2007: Ahn Kwang Seok; Sethi Gautam; Chao Ta-Hsiang; Neuteboom Saskia T C; Chaturvedi Madan M; Palladino Michael A; Younes Anas; Aggarwal Bharat B
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood 2007;110(7):2286-95.
2007: Pathak Ashutosh K; Bhutani Manisha; Nair Asha S; Ahn Kwang Seok; Chakraborty Arup; Kadara Humam; Guha Sushovan; Sethi Gautam; Aggarwal Bharat B
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Molecular cancer research : MCR 2007;5(9):943-55.
2007: Sethi Gautam; Ahn Kwang Seok; Xia Dianren; Kurie Jonathan M; Aggarwal Bharat B
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1926-33.
2007: Sandur Santosh K; Ichikawa Haruyo; Pandey Manoj K; Kunnumakkara Ajaikumar B; Sung Bokyung; Sethi Gautam; Aggarwal Bharat B
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Free radical biology & medicine 2007;43(4):568-80.
2007: Sandur Santosh K; Pandey Manoj K; Sung Bokyung; Ahn Kwang Seok; Murakami Akira; Sethi Gautam; Limtrakul Pornngarm; Badmaev Vladimir; Aggarwal Bharat B
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Carcinogenesis 2007;28(8):1765-73.
2007: Sethi Gautam; Aggarwal Bharat B
Mending the bones with natural products.
Chemistry & biology 2007;14(7):738-40.
2007: Shishodia Shishir; Chaturvedi Madan M; Aggarwal Bharat B
Role of curcumin in cancer therapy.
Current problems in cancer 2007;31(4):243-305.
2007: Aoki Hiroshi; Takada Yasunari; Kondo Seiji; Sawaya Raymond; Aggarwal Bharat B; Kondo Yasuko
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Molecular pharmacology 2007;72(1):29-39.
2007: Bover Laura C; Cardó-Vila Marina; Kuniyasu Akihiko; Sun Jessica; Rangel Roberto; Takeya Motohiro; Aggarwal Bharat B; Arap Wadih; Pasqualini Renata
A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8183-94.
2007: Lin Yvonne G; Kunnumakkara Ajaikumar B; Nair Asha; Merritt William M; Han Liz Y; Armaiz-Pena Guillermo N; Kamat Aparna A; Spannuth Whitney A; Gershenson David M; Lutgendorf Susan K; Aggarwal Bharat B; Sood Anil K
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3423-30.
2007: Khanna Dinesh; Sethi Gautam; Ahn Kwang Seok; Pandey Manoj K; Kunnumakkara Ajaikumar B; Sung Bokyung; Aggarwal Amita; Aggarwal Bharat B
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Shishodia Shishir; Sethi Gautam; Ahn Kwang Seok; Aggarwal Bharat B
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Biochemical pharmacology 2007;74(1):118-30.
2007: Pandey Manoj K; Sandur Santosh K; Sung Bokyung; Sethi Gautam; Kunnumakkara Ajaikumar B; Aggarwal Bharat B
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
The Journal of biological chemistry 2007;282(24):17340-50.
2007: Sung Bokyung; Pandey Manoj K; Aggarwal Bharat B
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
Molecular pharmacology 2007;71(6):1703-14.
2007: Sawhney Meenakshi; Rohatgi Nidhi; Kaur Jatinder; Shishodia Shishir; Sethi Gautam; Gupta Siddhartha D; Deo Suryanaryana V S; Shukla Nootan K; Aggarwal Bharat B; Ralhan Ranju
Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco.
International journal of cancer. Journal international du cancer 2007;120(12):2545-56.
2007: Kunnumakkara Ajaikumar B; Nair Asha S; Ahn Kwang Seok; Pandey Manoj K; Yi Zhengfang; Liu Mingyao; Aggarwal Bharat B
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Blood 2007;109(12):5112-21.
2007: Koul Dimpy; Shen Ruijun; Shishodia Shishir; Takada Yasanuri; Bhat Krishna P; Reddy Shrikanth A G; Aggarwal Bharat B; Yung W K Alfred
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Molecular and cellular biochemistry 2007;300(1-2):77-87.
2007: Bhutani Manisha; Pathak Ashutosh K; Nair Asha S; Kunnumakkara Ajaikumar B; Guha Sushovan; Sethi Gautam; Aggarwal Bharat B
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3024-32.
2007: Izzo Julie G; Luthra Rajyalakshmi; Wu Tseung-Teh; Correa Arlene M; Luthra Madan; Anandasabapathy Sharmila; Chao K S Clifford; Hung Mien-Chie; Aggarwal Bharat; Hittelman Walter N; Ajani Jaffer A
Molecular mechanisms in Barrett's metaplasia and its progression.
Seminars in oncology 2007;34(2 Suppl 1):S2-6.
2007: Kunnumakkara Ajaikumar B; Guha Sushovan; Krishnan Sunil; Diagaradjane Parmeswaran; Gelovani Juri; Aggarwal Bharat B
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Cancer research 2007;67(8):3853-61.
2007: Manna Sunil K; Aggarwal Rishi S; Sethi Gautam; Aggarwal Bharat B; Ramesh Govindarajan T
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2290-7.
2007: Aggarwal Bharat B; Banerjee Sanjeev; Bharadwaj Uddalak; Sung Bokyung; Shishodia Shishir; Sethi Gautam
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Biochemical pharmacology 2007;73(7):1024-32.
2007: Sethi Gautam; Ahn Kwang Seok; Pandey Manoj K; Aggarwal Bharat B
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
Blood 2007;109(7):2727-35.
2007: Kamat Ashish M; Sethi Gautam; Aggarwal Bharat B
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
Molecular cancer therapeutics 2007;6(3):1022-30.
2007: Bhardwaj Anjana; Sethi Gautam; Vadhan-Raj Saroj; Bueso-Ramos Carlos; Takada Yasunari; Gaur Upasna; Nair Asha S; Shishodia Shishir; Aggarwal Bharat B
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Blood 2007;109(6):2293-302.
2007: Jackson-Bernitsas D G; Ichikawa H; Takada Y; Myers J N; Lin X L; Darnay B G; Chaturvedi M M; Aggarwal B B
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Oncogene 2007;26(10):1385-97.
2007: Ahn Kwang Seok; Sethi Gautam; Aggarwal Bharat B
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2507-16.
2007: Aggarwal Bharat B
Nuclear factor-kappa B: a transcription factor for all seasons.
Expert opinion on therapeutic targets 2007;11(2):109-10.
2007: Xia Dianren; Srinivas Harish; Ahn Young-Ho; Sethi Gautam; Sheng Xiaoyang; Yung W K Alfred; Xia Qianghua; Chiao Paul J; Kim Heetae; Brown Powel H; Wistuba Ignacio I; Aggarwal Bharat B; Kurie Jonathan M
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.
The Journal of biological chemistry 2007;282(6):3507-19.
2007: Takada Y; Ichikawa H; Pataer A; Swisher S; Aggarwal B B
Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
Oncogene 2007;26(8):1201-12.
2007: Jagetia Ganesh Chandra; Aggarwal Bharat B
"Spicing up" of the immune system by curcumin.
Journal of clinical immunology 2007;27(1):19-35.
2007: Ahn Kwang Seok; Sethi Gautam; Krishnan Koyamangalath; Aggarwal Bharat B
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
The Journal of biological chemistry 2007;282(1):809-20.
2007: Ahn Kwang Seok; Sethi Gautam; Aggarwal Bharat B
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology 2007;71(1):209-19.
2007: Ichikawa Haruyo; Nakamura Yutaka; Kashiwada Yoshiki; Aggarwal Bharat B
Anticancer drugs designed by mother nature: ancient drugs but modern targets.
Current pharmaceutical design 2007;13(33):3400-16.
2007: Aggarwal Bharat B; Sundaram Chitra; Malani Nikita; Ichikawa Haruyo
Curcumin: the Indian solid gold.
Advances in experimental medicine and biology 2007;595():1-75.
2007: Sandur Santosh K; Ahn Kwang Seok; Ichikawa Haruyo; Sethi Gautam; Shishodia Shishir; Newman Robert A; Aggarwal Bharat B
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
Nutrition and cancer 2007;57(1):78-87.
2007: Garodia Prachi; Ichikawa Haruyo; Malani Nikita; Sethi Gautam; Aggarwal Bharat B
From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.
Journal of the Society for Integrative Oncology 2007;5(1):25-37.
2006: Aggarwal Bharat B; Sethi Gautam; Ahn Kwang Seok; Sandur Santosh K; Pandey Manoj K; Kunnumakkara Ajaikumar B; Sung Bokyung; Ichikawa Haruyo
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Tang Ximing; Liu Diane; Shishodia Shishir; Ozburn Natalie; Behrens Carmen; Lee J Jack; Hong Waun Ki; Aggarwal Bharat B; Wistuba Ignacio I
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Cancer 2006;107(11):2637-46.
2006: Mehta K; Gandhi V; Aggarwal B B
All pathways to cancer apoptosis meeting in Thiruvananthapuram (India).
Cell death and differentiation 2006;13(12):2163-4.
2006: Agarwal Rajesh; Agarwal Charu; Ichikawa Haruyo; Singh Rana P; Aggarwal Bharat B
Anticancer potential of silymarin: from bench to bed side.
Anticancer research 2006;26(6B):4457-98.
2006: Izzo Julie G; Correa Arlene M; Wu Tsung-Teh; Malhotra Usha; Chao Clifford K S; Luthra Rajyalakshmi; Ensor Joe; Dekovich Alexander; Liao Zhongxing; Hittelman Walter N; Aggarwal Bharat B; Ajani Jaffer A
Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma.
Molecular cancer therapeutics 2006;5(11):2844-50.
2006: Koul Dimpy; Takada Yasunari; Shen Ruijun; Aggarwal Bharat B; Yung W K Alfred
PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.
Biochemical and biophysical research communications 2006;350(2):463-71.
2006: Sharma Chhavi; Kaur Jatinder; Shishodia Shishir; Aggarwal Bharat B; Ralhan Ranju
Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.
Toxicology 2006;228(1):1-15.
2006: Aggarwal Bharat B; Shishodia Shishir; Sandur Santosh K; Pandey Manoj K; Sethi Gautam
Inflammation and cancer: how hot is the link?
Biochemical pharmacology 2006;72(11):1605-21.
2006: Zambre Ajit P; Kulkarni V M; Padhye Subhash; Sandur Santosh K; Aggarwal Bharat B
Novel curcumin analogs targeting TNF-induced NF-kappaB activation and proliferation in human leukemic KBM-5 cells.
Bioorganic & medicinal chemistry 2006;14(21):7196-204.
2006: Ichikawa Haruyo; Nair Mangalam S; Takada Yasunari; Sheeja D B Alan; Kumar M A Suresh; Oommen Oommen V; Aggarwal Bharat B
Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5910-8.
2006: Nair Asha S; Shishodia Shishir; Ahn Kwang Seok; Kunnumakkara Ajaikumar B; Sethi Gautam; Aggarwal Bharat B
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5612-22.
2006: Ahn Kwang Seok; Sethi Gautam; Shishodia Shishir; Sung Bokyung; Arbiser Jack L; Aggarwal Bharat B
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Molecular cancer research : MCR 2006;4(9):621-33.
2006: Mann Aman P; Verma Amit; Sethi Gautam; Manavathi Bramanandam; Wang Huamin; Fok Jansina Y; Kunnumakkara Ajaikumar B; Kumar Rakesh; Aggarwal Bharat B; Mehta Kapil
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
Cancer research 2006;66(17):8788-95.
2006: Chakravarti Nitin; Myers Jeffrey N; Aggarwal Bharat B
Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).
International journal of cancer. Journal international du cancer 2006;119(6):1268-75.
2006: Sethi Gautam; Ahn Kwang Seok; Sandur Santosh K; Lin Xin; Chaturvedi Madan M; Aggarwal Bharat B
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
The Journal of biological chemistry 2006;281(33):23425-35.
2006: Ahn Kwang Seok; Sethi Gautam; Jain Abhinav K; Jaiswal Anil K; Aggarwal Bharat B
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
The Journal of biological chemistry 2006;281(29):19798-808.
2006: Ichikawa Haruyo; Takada Yasunari; Shishodia Shishir; Jayaprakasam Bolleddula; Nair Muraleedharan G; Aggarwal Bharat B
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.
Molecular cancer therapeutics 2006;5(6):1434-45.
2006: Sandur Santosh K; Ichikawa Haruyo; Sethi Gautam; Ahn Kwang Seok; Aggarwal Bharat B
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
The Journal of biological chemistry 2006;281(25):17023-33.
2006: Aggarwal Bharat B; Shishodia Shishir
Molecular targets of dietary agents for prevention and therapy of cancer.
Biochemical pharmacology 2006;71(10):1397-421.
2006: Ichikawa Haruyo; Murakami Akira; Aggarwal Bharat B
1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation.
Molecular cancer research : MCR 2006;4(4):275-81.
2006: Shishodia Shishir; Sethi Gautam; Konopleva Marina; Andreeff Michael; Aggarwal Bharat B
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1828-38.
2006: Takada Yasunari; Ichikawa Haruyo; Badmaev Vladimir; Aggarwal Bharat B
Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3127-40.
2006: Takada Yasunari; Gillenwater Ann; Ichikawa Haruyo; Aggarwal Bharat B
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
The Journal of biological chemistry 2006;281(9):5612-22.
2006: Shishodia S; Aggarwal B B
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression.
Oncogene 2006;25(10):1463-73.
2006: Adams Lynn S; Seeram Navindra P; Aggarwal Bharat B; Takada Yasunari; Sand Daniel; Heber David
Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.
Journal of agricultural and food chemistry 2006;54(3):980-5.
2006: Aggarwal Bharat B; Ichikawa Haruyo; Garodia Prachi; Weerasinghe Priya; Sethi Gautam; Bhatt Indra D; Pandey Manoj K; Shishodia Shishir; Nair Muraleedharan G
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.
Expert opinion on therapeutic targets 2006;10(1):87-118.
2006: Izzo Julie G; Malhotra Usha; Wu Tsung-Teh; Ensor Joe; Luthra Rajyalakshmi; Lee Jeffrey H; Swisher Stephen G; Liao Zhongxing; Chao K S Clifford; Hittelman Walter N; Aggarwal Bharat B; Ajani Jaffer A
Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(5):748-54.
2006: Ichikawa Haruyo; Aggarwal Bharat B
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):662-8.
2006: Gulati Anthony P; Yang Yang-Ming; Harter David; Mukhopadhyay Asok; Aggarwal Bharat B; Benzil Deborah L; Whysner John; Albino Anthony P; Murali Raj; Jhanwar-Uniyal Meena
Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.
Molecular carcinogenesis 2006;45(1):26-37.
2006: Aggarwal Sita; Ichikawa Haruyo; Takada Yasunari; Sandur Santosh K; Shishodia Shishir; Aggarwal Bharat B
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Molecular pharmacology 2006;69(1):195-206.
2005: Buchholz Thomas A; Garg Amit K; Chakravarti Nitin; Aggarwal Bharat B; Esteva Francisco J; Kuerer Henry M; Singletary S Eva; Hortobagyi Gabriel N; Pusztai Lajos; Cristofanilli Massimo; Sahin Aysegul A
The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(23):8398-402.
2005: Varin Audrey; Decrion Anne-Zélie; Sabbah Emmanuelle; Quivy Vincent; Sire Joséphine; Van Lint Carine; Roques Bernard P; Aggarwal Bharat B; Herbein Georges
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
The Journal of biological chemistry 2005;280(52):42557-67.
2005: Ahn Kwang Seok; Aggarwal Bharat B
Transcription factor NF-kappaB: a sensor for smoke and stress signals.
Annals of the New York Academy of Sciences 2005;1056():218-33.
2005: Shishodia Shishir; Sethi Gautam; Aggarwal Bharat B
Curcumin: getting back to the roots.
Annals of the New York Academy of Sciences 2005;1056():206-17.
2005: Garg Amit K; Buchholz Thomas A; Aggarwal Bharat B
Chemosensitization and radiosensitization of tumors by plant polyphenols.
Antioxidants & redox signaling 2005;7(11-12):1630-47.
2005: Aggarwal Bharat B; Shishodia Shishir; Takada Yasunari; Banerjee Sanjeev; Newman Robert A; Bueso-Ramos Carlos E; Price Janet E
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7490-8.
2005: Shishodia Shishir; Gutierrez Angelica M; Lotan Reuben; Aggarwal Bharat B
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
Cancer research 2005;65(20):9555-65.
2005: Takada Yasunari; Murakami Akira; Aggarwal Bharat B
Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.
Oncogene 2005;24(46):6957-69.
2005: Aggarwal Bharat B; Ichikawa Haruyo
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Cell cycle (Georgetown, Tex.) 2005;4(9):1201-15.
2005: Shishodia Shishir; Amin Hesham M; Lai Raymond; Aggarwal Bharat B
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
Biochemical pharmacology 2005;70(5):700-13.
2005: Siwak Doris R; Shishodia Shishir; Aggarwal Bharat B; Kurzrock Razelle
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
Cancer 2005;104(4):879-90.
2005: Amit-Vazina M; Shishodia S; Harris D; Van Q; Wang M; Weber D; Alexanian R; Talpaz M; Aggarwal B B; Estrov Z
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells.
British journal of cancer 2005;93(1):70-80.
2005: Takada Yasunari; Andreeff Michael; Aggarwal Bharat B
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Blood 2005;106(2):641-9.
2005: Ichikawa Haruyo; Takada Yasunari; Murakami Akira; Aggarwal Bharat B
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7383-92.
2005: Takada Yasunari; Kobayashi Yoshinori; Aggarwal Bharat B
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
The Journal of biological chemistry 2005;280(17):17203-12.
2005: Shakibaei Mehdi; Schulze-Tanzil Gundula; Takada Yasunari; Aggarwal Bharat B
Redox regulation of apoptosis by members of the TNF superfamily.
Antioxidants & redox signaling 2005;7(3-4):482-96.
2005: Yan Chunhong; Jamaluddin Md S; Aggarwal Bharat; Myers Jeffrey; Boyd Douglas D
Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.
Molecular cancer therapeutics 2005;4(2):233-41.
2005: Aggarwal Bharat B; Takada Yasunari
Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-kappaB.
Cancer treatment and research 2005;126():103-27.
2005: Bharti Alok C; Takada Yasunari; Aggarwal Bharat B
PARP cleavage and caspase activity to assess chemosensitivity.
Methods in molecular medicine 2005;111():69-78.
2004: Aggarwal Bharat B; Shishodia Shishir
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Annals of the New York Academy of Sciences 2004;1030():434-41.
2004: Takada Yasunari; Bhardwaj Anjana; Potdar Pravin; Aggarwal Bharat B
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.
Oncogene 2004;23(57):9247-58.
2004: Takada Yasunari; Aggarwal Bharat B
Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling.
Blood 2004;104(13):4113-21.
2004: Dorai Thambi; Aggarwal Bharat B
Role of chemopreventive agents in cancer therapy.
Cancer letters 2004;215(2):129-40.
2004: Li Lan; Aggarwal Bharat B; Shishodia Shishir; Abbruzzese James; Kurzrock Razelle
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
Cancer 2004;101(10):2351-62.
2004: Shishodia Shishir; Aggarwal Bharat B
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
The Journal of biological chemistry 2004;279(45):47148-58.
2004: Aggarwal Bharat B; Takada Yasunari; Oommen Oommen V
From chemoprevention to chemotherapy: common targets and common goals.
Expert opinion on investigational drugs 2004;13(10):1327-38.
2004: Aggarwal Sita; Takada Yasunari; Mhashilkar Abner M; Sieger Kerry; Chada Sunil; Aggarwal Bharat B
Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4368-76.
2004: Aggarwal Bharat B; Bhardwaj Anjana; Aggarwal Rishi S; Seeram Navindra P; Shishodia Shishir; Takada Yasunari
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Anticancer research 2004;24(5A):2783-840.
2004: Aggarwal Bharat B
Nuclear factor-kappaB: the enemy within.
Cancer cell 2004;6(3):203-8.
2004: Shishodia Shishir; Aggarwal Bharat B
Nuclear factor-kappaB: a friend or a foe in cancer?
Biochemical pharmacology 2004;68(6):1071-80.
2004: Aggarwal Sita; Takada Yasunari; Singh Sujay; Myers Jeffrey N; Aggarwal Bharat B
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
International journal of cancer. Journal international du cancer 2004;111(5):679-92.
2004: Takada Yasunari; Fang Xianjun; Jamaluddin Md Saha; Boyd Douglas D; Aggarwal Bharat B
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 2004;279(38):39541-54.
2004: Galindo Cristi L; Fadl Amin A; Sha Jian; Gutierrez Celso; Popov Vsevolod L; Boldogh Istvan; Aggarwal Bharat B; Chopra Ashok K
Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells.
The Journal of biological chemistry 2004;279(36):37597-612.
2004: Shishodia Shishir; Koul Dimpy; Aggarwal Bharat B
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2011-22.
2004: Shishodia Shishir; Aggarwal Bharat B
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.
Cancer research 2004;64(14):5004-12.
2004: Takada Yasunari; Aggarwal Bharat B
TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1066-77.
2004: Kumar Ashok; Takada Yasunari; Boriek Aladin M; Aggarwal Bharat B
Nuclear factor-kappaB: its role in health and disease.
Journal of molecular medicine (Berlin, Germany) 2004;82(7):434-48.
2004: Takada Yasunari; Khuri Fadlo R; Aggarwal Bharat B
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
The Journal of biological chemistry 2004;279(25):26287-99.
2004: Zheng Bei; Georgakis Georgios V; Li Yang; Bharti Alok; McConkey David; Aggarwal Bharat B; Younes Anas
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3207-15.
2004: Bharti Alok C; Takada Yasunari; Aggarwal Bharat B
Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5940-7.
2004: Aggarwal Bharat B; Takada Yasunari; Shishodia Shishir; Gutierrez Angelica M; Oommen Oommen V; Ichikawa Haruyo; Baba Yuh; Kumar Ashok
Nuclear transcription factor NF-kappa B: role in biology and medicine.
Indian journal of experimental biology 2004;42(4):341-53.
2004: Bharti Alok C; Shishodia Shishir; Reuben James M; Weber Donna; Alexanian Raymond; Raj-Vadhan Saroj; Estrov Zeev; Talpaz Moshe; Aggarwal Bharat B
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis.
Blood 2004;103(8):3175-84.
2004: Chatterjee Devasis; Bai Yin; Wang Zhe; Beach Sandy; Mott Stephanie; Roy Rajat; Braastad Corey; Sun Yaping; Mukhopadhyay Asok; Aggarwal Bharat B; Darnowski James; Pantazis Panayotis; Wyche James; Fu Zheng; Kitagwa Yasuhide; Keller Evan T; Sedivy John M; Yeung Kam C
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis.
The Journal of biological chemistry 2004;279(17):17515-23.
2004: Takada Yasunari; Singh Sujay; Aggarwal Bharat B
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
The Journal of biological chemistry 2004;279(15):15096-104.
2004: Yan Chunhong; Wang Heng; Aggarwal Bharat; Boyd Douglas D
A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):540-1.
2004: Fang Xianjun; Yu Shuangxing; Bast Robert C; Liu Shuying; Xu Hong-Ji; Hu Shi-Xue; LaPushin Ruth; Claret Francois X; Aggarwal Bharat B; Lu Yiling; Mills Gordon B
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2004: Bueso-Ramos Carlos E; Rocha Frederico C; Shishodia Shishir; Medeiros L Jeffrey; Kantarjian Hagop M; Vadhan-Raj Saroj; Estrov Zeev; Smith Terry L; Nguyen Martin H; Aggarwal Bharat B
Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia.
Human pathology 2004;35(2):246-53.
2004: Bharti Alok C; Takada Yasunari; Shishodia Shishir; Aggarwal Bharat B
Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism.
The Journal of biological chemistry 2004;279(7):6065-76.
2004: Takada Yasunari; Aggarwal Bharat B
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
The Journal of biological chemistry 2004;279(6):4750-9.
2004: Donato Nicholas J; Wu Ji Y; Stapley Jonathan; Lin Hui; Arlinghaus Ralph; Aggarwal Bharat B; Shishodia Shishir; Albitar Maher; Hayes Kimberly; Kantarjian Hagop; Talpaz Moshe;
Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia.
Cancer research 2004;64(2):672-7.
2004: Ashikawa Kazuhiro; Shishodia Shishir; Fokt Izabel; Priebe Waldemar; Aggarwal Bharat B
Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues.
Biochemical pharmacology 2004;67(2):353-64.
2004: Shishodia Shishir; Aggarwal Bharat B
Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer.
Cancer treatment and research 2004;119():139-73.
2004: Aggarwal Bharat B; Bhardwaj Uddalak; Takada Yasunari
Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors.
Vitamins and hormones 2004;67():453-83.
2003: Garg Amit K; Hortobagyi Gabriel N; Aggarwal Bharat B; Sahin Aysegul A; Buchholz Thomas A
Nuclear factor-kappa B as a predictor of treatment response in breast cancer.
Current opinion in oncology 2003;15(6):405-11.
2003: Thompson M P; Aggarwal B B; Shishodia S; Estrov Z; Kurzrock R
Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells: induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(11):2196-201.
2003: Gaur Upasna; Aggarwal Bharat B
Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.
Biochemical pharmacology 2003;66(8):1403-8.
2003: Bharti Alok C; Donato Nicholas; Aggarwal Bharat B
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3863-71.
2003: Bhardwaj Anjana; Aggarwal Bharat B
Receptor-mediated choreography of life and death.
Journal of clinical immunology 2003;23(5):317-32.
2003: Takada Yasunari; Aggarwal Bharat B
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3278-86.
2003: Aggarwal Bharat B
Signalling pathways of the TNF superfamily: a double-edged sword.
Nature reviews. Immunology 2003;3(9):745-56.
2003: Shishodia Shishir; Majumdar Sekhar; Banerjee Sanjeev; Aggarwal Bharat B
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Cancer research 2003;63(15):4375-83.
2003: Estrov Zeev; Shishodia Shishir; Faderl Stefan; Harris David; Van Quin; Kantarjian Hagop M; Talpaz Moshe; Aggarwal Bharat B
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.
Blood 2003;102(3):987-95.
2003: Shishodia Shishir; Potdar Pravin; Gairola C Gary; Aggarwal Bharat B
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.
Carcinogenesis 2003;24(7):1269-79.
2003: Younes Anas; Garg Amit; Aggarwal Bharat B
Nuclear transcription factor-kappaB in Hodgkin's disease.
Leukemia & lymphoma 2003;44(6):929-35.
2003: Takada Yasunari; Mukhopadhyay Asok; Kundu Gopal C; Mahabeleshwar Ganapati H; Singh Sujay; Aggarwal Bharat B
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.
The Journal of biological chemistry 2003;278(26):24233-41.
2003: Takada Yasunari; Aggarwal Bharat B
Genetic deletion of the tumor necrosis factor receptor p60 or p80 sensitizes macrophages to lipopolysaccharide-induced nuclear factor-kappa B, mitogen-activated protein kinases, and apoptosis.
The Journal of biological chemistry 2003;278(26):23390-7.
2003: Majumdar Sekhar; Aggarwal Bharat B
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Oncogene 2003;22(8):1206-18.
2003: Manna Sunil K; Bueso-Ramos Carlos; Alvarado Francisco; Aggarwal Bharat B
Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents.
Cancer letters 2003;190(2):171-82.
2003: Bharti Alok C; Donato Nicholas; Singh Sujay; Aggarwal Bharat B
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Blood 2003;101(3):1053-62.
2003: Aggarwal Bharat B; Kumar Anushree; Bharti Alok C
Anticancer potential of curcumin: preclinical and clinical studies.
Anticancer research 2003;23(1A):363-98.
2003: Varin Audrey; Manna Sunil K; Quivy Vincent; Decrion Anne-Zélie; Van Lint Carine; Herbein Georges; Aggarwal Bharat B
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.
The Journal of biological chemistry 2003;278(4):2219-27.
2002: Aggarwal Bharat B; Shishodia Shishir; Ashikawa Kazuhiro; Bharti Alok C
The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.
Current drug targets. Inflammation and allergy 2002;1(4):327-41.
2002: Higuchi Masahiro; Manna Sunil K; Sasaki Ryouhei; Aggarwal Bharat B
Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways.
Antioxidants & redox signaling 2002;4(6):945-55.
2002: Mukhopadhyay Asok; Banerjee Sanjeev; Stafford Lewis Joe; Xia Chunzhi; Liu Mingyao; Aggarwal Bharat B
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Oncogene 2002;21(57):8852-61.
2002: Ashikawa Kazuhiro; Majumdar Sekhar; Banerjee Sanjeev; Bharti Alok C; Shishodia Shishir; Aggarwal Bharat B
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6490-7.
2002: Garg Amit K; Aggarwal Bharat B
Reactive oxygen intermediates in TNF signaling.
Molecular immunology 2002;39(9):509-17.
2002: Bharti Alok C; Aggarwal Bharat B
Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization.
Annals of the New York Academy of Sciences 2002;973():392-5.
2002: Bharti Alok C; Aggarwal Bharat B
Nuclear factor-kappa B and cancer: its role in prevention and therapy.
Biochemical pharmacology 2002;64(5-6):883-8.
2002: Banerjee Sanjeev; Bueso-Ramos Carlos; Aggarwal Bharat B
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.
Cancer research 2002;62(17):4945-54.
2002: Anto Ruby John; Mukhopadhyay Asok; Shishodia Shishir; Gairola C Gary; Aggarwal Bharat B
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Carcinogenesis 2002;23(9):1511-8.
2002: Ramana Kota V; Chandra Deepak; Srivastava Sanjay; Bhatnagar Aruni; Aggarwal Bharat B; Srivastava Satish K
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(35):32063-70.
2002: Mukhopadhyay Asok; Shishodia Shishir; Suttles Jill; Brittingham Katherine; Lamothe Betty; Nimmanapalli Ramdevi; Bhalla Kapil N; Aggarwal Bharat B
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.
The Journal of biological chemistry 2002;277(34):30622-8.
2002: Raza Shaan M; Lang Frederick F; Aggarwal Bharat B; Fuller Gregory N; Wildrick David M; Sawaya Raymond
Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis.
Neurosurgery 2002;51(1):2-12; discussion 12-3.
2002: Garg A; Aggarwal B B
Nuclear transcription factor-kappaB as a target for cancer drug development.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(6):1053-68.
2002: Majumdar Sekhar; Lamothe Betty; Aggarwal Bharat B
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2644-51.
2002: Lamothe Betty; Aggarwal Bharat B
Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(2):269-79.
2002: Shishodia Shishir; Aggarwal Bharat B
Nuclear factor-kappaB activation: a question of life or death.
Journal of biochemistry and molecular biology 2002;35(1):28-40.
2002: Anto Ruby John; Mukhopadhyay Asok; Denning Kate; Aggarwal Bharat B
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.
Carcinogenesis 2002;23(1):143-50.
2002: Mukhopadhyay Asok; Shishodia Shishir; Fu Xin-Yuan; Aggarwal Bharat B
Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha.
Journal of cellular biochemistry 2002;84(4):803-15.
2001: Mukhopadhyay A; Bueso-Ramos C; Chatterjee D; Pantazis P; Aggarwal B B
Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines.
Oncogene 2001;20(52):7597-609.
2001: Fiumara P; Snell V; Li Y; Mukhopadhyay A; Younes M; Gillenwater A M; Cabanillas F; Aggarwal B B; Younes A
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Blood 2001;98(9):2784-90.
2001: Majumdar S; Aggarwal B B
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2911-20.
2001: Mukhopadhyay A; Suttles J; Stout R D; Aggarwal B B
Genetic deletion of the tumor necrosis factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages.
The Journal of biological chemistry 2001;276(34):31906-12.
2001: Rath P C; Aggarwal B B
Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(7):523-8.
2000: Manna S K; Mukhopadhyay A; Aggarwal B B
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5962-9.
2000: Aggarwal B B
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB.
Annals of the rheumatic diseases 2000;59 Suppl 1():i6-16.
2000: Manna S K; Mukhopadhyay A; Aggarwal B B
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4927-34.
2000: Aggarwal B B
Apoptosis and nuclear factor-kappa B: a tale of association and dissociation.
Biochemical pharmacology 2000;60(8):1033-9.
2000: Manna S K; Haridas V; Aggarwal B B
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(8):725-35.
2000: Manna S K; Sah N K; Newman R A; Cisneros A; Aggarwal B B
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
Cancer research 2000;60(14):3838-47.
2000: Chainy G B; Manna S K; Chaturvedi M M; Aggarwal B B
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis.
Oncogene 2000;19(25):2943-50.
2000: Manna S K; Mukhopadhyay A; Aggarwal B B
Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6509-19.
2000: Manna S K; Aggarwal B B
Vesnarinone suppresses TNF-induced activation of NF-kappa B, c-Jun kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5815-25.
2000: Manna S K; Aggarwal B B
Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester.
FEBS letters 2000;473(1):113-8.
2000: Manna S K; Aggarwal B B
Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5156-66.
2000: Manna S K; Mukhopadhyay A; Aggarwal B B
Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor.
The Journal of biological chemistry 2000;275(18):13307-14.
2000: Manna S K; Sah N K; Aggarwal B B
Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis.
The Journal of biological chemistry 2000;275(18):13297-306.
2000: Manna S K; Aggarwal B B
All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells.
Oncogene 2000;19(17):2110-9.
2000: Mukhopadhyay A; Manna S K; Aggarwal B B
Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha.
The Journal of biological chemistry 2000;275(12):8549-55.
1999: Manna S K; Mukhopadhyay A; Van N T; Aggarwal B B
Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6800-9.
1999: Chintala S K; Kyritsis A P; Mohan P M; Mohanam S; Sawaya R; Gokslan Z; Yung W K; Steck P; Uhm J H; Aggarwal B B; Rao J S
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Molecular carcinogenesis 1999;26(4):274-85.
1999: Haridas V; Shrivastava A; Su J; Yu G L; Ni J; Liu D; Chen S F; Ni Y; Ruben S M; Gentz R; Aggarwal B B
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.
Oncogene 1999;18(47):6496-504.
1999: Kumar A; Dhawan S; Mukhopadhyay A; Aggarwal B B
Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.
FEBS letters 1999;462(1-2):140-4.
1999: Darnay B G; Aggarwal B B
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Annals of the rheumatic diseases 1999;58 Suppl 1():I2-I13.
1999: Estrov Z; Manna S K; Harris D; Van Q; Estey E H; Kantarjian H M; Talpaz M; Aggarwal B B
Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells.
Blood 1999;94(8):2844-53.
1999: Manna S K; Kuo M T; Aggarwal B B
Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1.
Oncogene 1999;18(30):4371-82.
1999: Mukhopadhyay A; Ni J; Zhai Y; Yu G L; Aggarwal B B
Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.
The Journal of biological chemistry 1999;274(23):15978-81.
1999: Manna S K; Gad Y P; Mukhopadhyay A; Aggarwal B B
Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.
Biochemical pharmacology 1999;57(7):763-74.
1999: Darnay B G; Ni J; Moore P A; Aggarwal B B
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
The Journal of biological chemistry 1999;274(12):7724-31.
1999: Manna S K; Aggarwal B B
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2095-102.
1999: Manna S K; Aggarwal B B
Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1510-8.
1999: Zhai Y; Ni J; Jiang G W; Lu J; Xing L; Lincoln C; Carter K C; Janat F; Kozak D; Xu S; Rojas L; Aggarwal B B; Ruben S; Li L Y; Gentz R; Yu G L
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):181-9.
1999: Shrivastava A; Aggarwal B B
Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis.
Antioxidants & redox signaling 1999;1(2):181-91.
1998: Manna S K; Aggarwal B B
Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13.
The Journal of biological chemistry 1998;273(50):33333-41.
1998: Shrivastava A; Manna S K; Ray R; Aggarwal B B
Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors.
Journal of virology 1998;72(12):9722-8.
1998: Giri D K; Mehta R T; Kansal R G; Aggarwal B B
Mycobacterium avium-intracellulare complex activates nuclear transcription factor-kappaB in different cell types through reactive oxygen intermediates.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4834-41.
1998: Singh S; Raju U; Mendoza J; Pantazis P; Aggarwal B B
Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells.
Anti-cancer drugs 1998;9(8):703-14.
1998: Manna S K; Aggarwal B B
Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2873-80.
1998: Manna S K; Aggarwal B B
IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2863-72.
1998: Kumar A; Dhawan S; Aggarwal B B
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.
Oncogene 1998;17(7):913-8.
1998: Wright-Browne V; Schnee A M; Jenkins M A; Thall P F; Aggarwal B B; Talpaz M; Estrov Z
Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence.
Leukemia & lymphoma 1998;30(5-6):583-9.
1998: Darnay B G; Haridas V; Ni J; Moore P A; Aggarwal B B
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(32):20551-5.
1998: Singh A; Ni J; Aggarwal B B
Death domain receptors and their role in cell demise.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(7):439-50.
1998: Kumar A; Manna S K; Dhawan S; Aggarwal B B
HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):776-81.
1998: Kwon B S; Wang S; Udagawa N; Haridas V; Lee Z H; Kim K K; Oh K O; Greene J; Li Y; Su J; Gentz R; Aggarwal B B; Ni J
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(10):845-54.
1998: Haridas V; Ni J; Meager A; Su J; Yu G L; Zhai Y; Kyaw H; Akama K T; Hu J; Van Eldik L J; Aggarwal B B
TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):1-6.
1998: Giri D K; Aggarwal B B
Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates.
The Journal of biological chemistry 1998;273(22):14008-14.
1998: Chintala S K; Sawaya R; Aggarwal B B; Majumder S; Giri D K; Kyritsis A P; Gokaslan Z L; Rao J S
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
The Journal of biological chemistry 1998;273(22):13545-51.
1998: Manna S K; Zhang H J; Yan T; Oberley L W; Aggarwal B B
Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1.
The Journal of biological chemistry 1998;273(21):13245-54.
1998: Haridas V; Darnay B G; Natarajan K; Heller R; Aggarwal B B
Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3152-62.
1998: Natarajan K; Manna S K; Chaturvedi M M; Aggarwal B B
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.
Archives of biochemistry and biophysics 1998;352(1):59-70.
1998: Kumar A; Dhawan S; Hardegen N J; Aggarwal B B
Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.
Biochemical pharmacology 1998;55(6):775-83.
1998: Mukherjee R; Singh S; Chaturvedi M M; Aggarwal B B
Evidence for a synergistic role of two types of human tumor necrosis factor receptors for the ligand-dependent activation of the nuclear transcription factor NF-kappaB.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(2):117-23.
1998: Shrivastava A; Aggarwal B B
Cytokines as biological regulators of homeostasis.
Journal of biological regulators and homeostatic agents 1998;12(1-2):1-24.
1997: Aggarwal B B; Higuchi M
Role of ceramide in tumour necrosis factor-mediated apoptosis and nuclear factor-kappa B activation.
Biochemical Society transactions 1997;25(4):1166-71.
1997: Chaturvedi M M; Kumar A; Darnay B G; Chainy G B; Agarwal S; Aggarwal B B
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
The Journal of biological chemistry 1997;272(48):30129-34.
1997: Darnay B G; Aggarwal B B
Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase.
FEBS letters 1997;410(2-3):361-7.
1997: Mehta K; Pantazis P; McQueen T; Aggarwal B B
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.
Anti-cancer drugs 1997;8(5):470-81.
1997: Darnay B G; Aggarwal B B
Early events in TNF signaling: a story of associations and dissociations.
Journal of leukocyte biology 1997;61(5):559-66.
1997: Darnay B G; Singh S; Aggarwal B B
The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase.
FEBS letters 1997;406(1-2):101-5.
1997: McClain K; Estrov Z; Raju U; Kelley P K; Aggarwal B B
Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes.
Methods (San Diego, Calif.) 1997;11(1):83-7.
1996: Singh S; Darnay B G; Aggarwal B B
Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.
The Journal of biological chemistry 1996;271(49):31049-54.
1996: Aggarwal B B; Schwarz L; Hogan M E; Rando R F
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.
Cancer research 1996;56(22):5156-64.
1996: Singh S; Natarajan K; Aggarwal B B
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4412-20.
1996: Chainy G B; Singh S; Raju U; Aggarwal B B
Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2410-7.
1996: Natarajan K; Singh S; Burke T R; Grunberger D; Aggarwal B B
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9090-5.
1996: Higuchi M; Singh S; Jaffrezou J P; Aggarwal B B
Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):297-304.
1996: Aggarwal B B; Natarajan K
Tumor necrosis factors: developments during the last decade.
European cytokine network 1996;7(2):93-124.
1996: Totpal K; Singh S; Lapushin R; Aggarwal B B
Qualitative and quantitative differences in the cellular responses mediated through Fas antigen and tumor necrosis factor receptor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(3):259-67.
1995: Pocsik E; Mihalik R; Penzes M; Loetscher H; Gallati H; Aggarwal B B
Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors.
Journal of cellular biochemistry 1995;59(3):303-16.
1995: Estrov Z; Samal B; Lapushin R; Kellokumpu-Lehtinen P; Sahin A A; Kurzrock R; Talpaz M; Aggarwal B B
Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(10):905-13.
1995: Singh S; Aggarwal B B
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
The Journal of biological chemistry 1995;270(42):24995-5000.
1995: Higuchi M; Singh S; Chan H; Aggarwal B B
Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation.
Blood 1995;86(6):2248-56.
1995: Aggarwal B B; Pocsik E; Totpal K
Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor.
FEBS letters 1995;372(1):44-8.
1995: Darnay B G; Singh S; Chaturvedi M M; Aggarwal B B
The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signaling.
The Journal of biological chemistry 1995;270(25):14867-70.
1995: Totpal K; Chaturvedi M M; LaPushin R; Aggarwal B B
Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells.
Blood 1995;85(12):3547-55.
1995: Singh S; Aggarwal B B
Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.
The Journal of biological chemistry 1995;270(18):10631-9.
1995: Aggarwal B B; Totpal K; LaPushin R; Chaturvedi M M; Pereira-Smith O M; Smith J R
Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B.
Experimental cell research 1995;218(1):381-8.
1995: Aggarwal B B; Singh S; LaPushin R; Totpal K
Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor.
FEBS letters 1995;364(1):5-8.
1995: Aggarwal B B; Pocsik E; Totpal K; Ali-Osman F
Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
FEBS letters 1995;357(1):1-6.
1995: Higuchi M; Singh S; Aggarwal B B
Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells.
Journal of immunological methods 1995;178(2):173-81.
1995: Sella A; Aggarwal B B; Kilbourn R G; Bui C A; Zukiwski A A; Logothetis C J
Phase I study of tumor necrosis factor plus actinomycin D in patients with androgen-independent prostate cancer.
Cancer biotherapy 1995;10(3):225-35.
1994: Chan H; Aggarwal B B
Role of tumor necrosis factor receptors in the activation of nuclear factor kappa B in human histiocytic lymphoma U-937 cells.
The Journal of biological chemistry 1994;269(50):31424-9.
1994: Aggarwal B B; Pocsik E; Ali-Osman F; Totpal K
Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
FEBS letters 1994;354(1):12-6.
1994: Zhang L; Aggarwal B B
Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3745-54.
1994: Reddy S A; Chaturvedi M M; Darnay B G; Chan H; Higuchi M; Aggarwal B B
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.
The Journal of biological chemistry 1994;269(41):25369-72.
1994: Chaturvedi M M; Higuchi M; Aggarwal B B
Effect of tumor necrosis factors, interferons, interleukins, and growth factors on the activation of NF-kappa B: evidence for lack of correlation with cell proliferation.
Lymphokine and cytokine research 1994;13(5):309-13.
1994: Totpal K; LaPushin R; Kohno T; Darnay B G; Aggarwal B B
TNF and its receptor antibody agonist differ in mediation of cellular responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2248-57.
1994: Darnay B G; Reddy S A; Aggarwal B B
Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.
The Journal of biological chemistry 1994;269(32):20299-304.
1994: Darnay B G; Reddy S A; Aggarwal B B
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.
The Journal of biological chemistry 1994;269(31):19687-90.
1994: Chaturvedi M M; LaPushin R; Aggarwal B B
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
The Journal of biological chemistry 1994;269(20):14575-83.
1994: Aggarwal B B; Totpal K; Ali-Osman F; Budde R J; Pocsik E
pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
FEBS letters 1994;345(2-3):219-24.
1994: Higuchi M; Aggarwal B B
Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4017-25.
1994: Higuchi M; Aggarwal B B
TNF induces internalization of the p60 receptor and shedding of the p80 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3550-8.
1994: Zhang L; Higuchi M; Totpal K; Chaturvedi M M; Aggarwal B B
Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response.
The Journal of biological chemistry 1994;269(14):10270-9.
1994: Pocsik E; Mihalik R; Ali-Osman F; Aggarwal B B
Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response.
Journal of cellular biochemistry 1994;54(4):453-64.
1994: Reddy S; Aggarwal B B
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
FEBS letters 1994;341(1):19-22.
1994: Aggarwal B B; Pandita R
Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C.
FEBS letters 1994;337(1):99-102.
1994: LaPushin R; Totpal K; Higuchi M; Aggarwal B B
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.
Journal of clinical immunology 1994;14(1):39-49.
1993: Higuchi M; Aggarwal B B
P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation.
FEBS letters 1993;331(3):252-5.
1993: Aggarwal B B; Graff K; Samal B; Higuchi M; Liao W S
Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937.
Lymphokine and cytokine research 1993;12(3):149-58.
1993: Higuchi M; Aggarwal B B
Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.
The Journal of biological chemistry 1993;268(8):5624-31.
1993: Estrov Z; Kurzrock R; Pocsik E; Pathak S; Kantarjian H M; Zipf T F; Harris D; Talpaz M; Aggarwal B B
Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines.
The Journal of experimental medicine 1993;177(3):763-74.
1993: Aggarwal B B; Gadhia P K; Hopwood V L; Dave B J; Risin S; Owen-Schaub L; Pandita R; Pathak S
Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B lymphoblastoid cells derived from cancer patients.
Lymphokine and cytokine research 1993;12(1):9-19.
1992: Pocsik E; Higuchi M; Aggarwal B B
Down-modulation of cell surface expression of p80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene.
Lymphokine and cytokine research 1992;11(6):317-25.
1992: Pandita R; Pocsik E; Aggarwal B B
Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors.
FEBS letters 1992;312(1):87-90.
1992: Higuchi M; Aggarwal B B
Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.
The Journal of biological chemistry 1992;267(29):20892-9.
1992: Totpal K; Agarwal S; Aggarwal B B
Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells.
Cancer research 1992;52(9):2557-62.
1992: Fernandez A; Chen P W; Aggarwal B B; Ananthaswamy H N
Resistance of Ha-ras oncogene-induced progressor tumor variants to tumor necrosis factor and interferon-gamma.
Lymphokine and cytokine research 1992;11(2):79-85.
1992: Aggarwal B B; Pocsik E
Cytokines: from clone to clinic.
Archives of biochemistry and biophysics 1992;292(2):335-59.
1992: Higuchi M; Aggarwal B B
Inhibition of ligand binding and antiproliferative effects of tumor necrosis factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors.
Biochemical and biophysical research communications 1992;182(2):638-43.
1992: Aggarwal B B
Comparative analysis of the structure and function of TNF-alpha and TNF-beta.
Immunology series 1992;56():61-78.
1992: Ioannides C G; Fisk B; Tomasovic B; Pandita R; Aggarwal B B; Freedman R S
Induction of interleukin-2 receptor by tumor necrosis factor alpha on cultured ovarian tumor-associated lymphocytes.
Cancer immunology, immunotherapy : CII 1992;35(2):83-91.
1991: Totpal K; Lapushin R; Ananthaswamy H N; Aggarwal B B
In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo.
Lymphokine and cytokine research 1991;10(5):359-67.
1991: Totpal K; Aggarwal B B
Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines.
Cancer research 1991;51(16):4266-70.
1990: Sastry K J; Reddy H R; Pandita R; Totpal K; Aggarwal B B
HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line.
The Journal of biological chemistry 1990;265(33):20091-3.
1990: Aggarwal B B
Lymphotoxin and tumor necrosis factor: qualitative and quantitative differences in their receptors and signal transduction in various cell types.
Progress in clinical and biological research 1990;349():375-84.

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