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Bharat Aggarwal

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Varsha Gandhi; Kapil Mehta; Sen Pathak; Bharat B Aggarwal
Meeting report: leaders in translational cancer research meet in udaipur, a historical town of India: an international symposium on translational cancer research: cancer prevention. Udaipur, rajasthan, India, december 16-19, 2011.
Subash C Gupta; Kanokkarn Phromnoi; Bharat B Aggarwal
Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.
Subash C Gupta; Gorkem Kismali; Bharat B Aggarwal
Curcumin, a component of turmeric: from farm to pharmacy.

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2013: Varsha Gandhi; Kapil Mehta; Sen Pathak; Bharat B Aggarwal
Meeting report: leaders in translational cancer research meet in udaipur, a historical town of India: an international symposium on translational cancer research: cancer prevention. Udaipur, rajasthan, India, december 16-19, 2011.
Anticancer research 2013;33(4):1777-81.
2013: Subash C Gupta; Kanokkarn Phromnoi; Bharat B Aggarwal
Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.
Biochemical pharmacology 2013;85(7):898-912.
2013: Subash C Gupta; Gorkem Kismali; Bharat B Aggarwal
Curcumin, a component of turmeric: from farm to pharmacy.
BioFactors (Oxford, England) 2013;39(1):2-13.
2013: Subash C Gupta; Sridevi Patchva; Bharat B Aggarwal
Therapeutic roles of curcumin: lessons learned from clinical trials.
The AAPS journal 2013;15(1):195-218.
2012: Dona Sinha; Bokyung Sung; Bharat B Aggarwal; Jaydip Biswas; Anupam Bishayee
Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.
Current drug targets 2012;13(14):1799-819.
2012: Masanobu Takahashi; Bharat B Aggarwal; C Richard Boland; Keun Hur; Alexander Link; Yan Shen; Bokyung Sung; Ajay Goel
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
Carcinogenesis 2012;33(12):2441-9.
2012: Bokyung Sung; Vivek R Yadav; Sahdeo Prasad; Jayaraj Ravindran; Bharat B Aggarwal
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.
Free radical biology & medicine 2012;53(10):1977-87.
2012: Sahdeo Prasad; Simone Reuter; Bokyung Sung; Caimiao Wei; Vivek R Yadav; Veerabhadran Baladandayuthapani; Amit Deorukhkar; Parmeswaran Diagaradjane; Sushovan Guha; Ramaswamy Kannappan; Sunil Krishnan; Bharat B Aggarwal
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):4942-53.
2012: Mi-Ae Lyu; John W Marks; Lan V Pham; Bharat B Aggarwal; Kwang Seok Ahn; Lawrence H Cheung; Min-Jeong Cho; Richard J Ford; Walter N Hittelman; Bokyung Sung; Archito Tamayo; Michael G Rosenblum
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.
Biochemical pharmacology 2012;84(4):451-8.
2012: Ajaikumar Kunnumakkara; Jayaraj Ravindran; Bokyung Sung; Zhimin Tong; Amit Deorukhkar; Sanjit Dey; Parmeswaran Diagaradjane; Juri G Gelovani; Sushovan Guha; Cemile Koca; Sunil Krishnan; Bharat B Aggarwal
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets.
International journal of cancer. Journal international du cancer 2012;131(3):E292-303.
2012: Subash C Gupta; David Hevia; Wonil Koh; Byoungduck Park; Sridevi Patchva; Bharat B Aggarwal
Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.
Antioxidants & redox signaling 2012;16(11):1295-322.
2012: Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Age-associated chronic diseases require age-old medicine: role of chronic inflammation.
Preventive medicine 2012;54 Suppl():S29-37.
2012: Vivek R Yadav; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
International journal of cancer. Journal international du cancer 2012;130(9):2176-84.
2012: Simone Reuter; Subash C Gupta; Kanokkarn Phromnoi; Bharat B Aggarwal
Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.
British journal of pharmacology 2012;165(7):2127-39.
2012: Ji H Kim; Byoungduck Park; Vivek R Yadav; Subash C Gupta; Bharat B Aggarwal
Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
Molecular nutrition & food research 2012;56(3):454-65.
2012: Subash C Gupta; Wonil Koh; Sridevi Patchva; Bharat B Aggarwal
Discovery of curcumin, a component of golden spice, and its miraculous biological activities.
Clinical and experimental pharmacology & physiology 2012;39(3):283-99.
2012: Ji Hye Kim; Byoungduck Park; Bokyung Sung; Subash C Gupta; Ramaswamy Kannappan; Bharat B Aggarwal
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.
Antioxidants & redox signaling 2012;16(5):413-27.
2012: Bokyung Sung; Babatunde Oyajobi; Bharat B Aggarwal
Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling.
Molecular cancer therapeutics 2012;11(2):350-9.
2012: Bharat B Aggarwal; Subash C Gupta; Ji Hye Kim
Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.
Blood 2012;119(3):651-65.
2012: Noor Hasima; Bharat B Aggarwal
Cancer-linked targets modulated by curcumin.
International journal of biochemistry and molecular biology 2012;3(4):328-51.
2012: Rahul Checker; S Jayakumar; Vineet Kohli; Raghavendra S Patwardhan; Santosh K Sandur; Gautam Sethi; Deepak Sharma; Bharat B Aggarwal; Krishna B Sainis
Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT.
PloS one 2012;7(2):e31318.
2012: Anupam Kumar; Santosh Kumar; Bokyung Sung; Jia Xu; Dihua Yu; Bharat B Aggarwal; Kapil Mehta
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Breast cancer research : BCR 2012;14(1):R4.
2012: Bokyung Sung; Vivek R Yadav; Sahdeo Prasad; Bharat B Aggarwal
Cancer cell signaling pathways targeted by spice-derived nutraceuticals.
Nutrition and cancer 2012;64(2):173-97.
2012: Altaf S Darvesh; Bharat B Aggarwal; Anupam Bishayee
Curcumin and liver cancer: a review.
Current pharmaceutical biotechnology 2012;13(1):218-28.
2011: Preetha Anand; Ajaikumar Kunnumakkara; Kallikat N Rajasekharan; Bokyung Sung; Bharat B Aggarwal
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.
Biochemical pharmacology 2011;82(12):1901-9.
2011: Bharat B Aggarwal; Bokyung Sung
NF-κB in cancer: a matter of life and death.
Cancer discovery 2011;1(6):469-71.
2011: Subash C Gupta; Ji Hye Kim; Sridevi Patchva; Sahdeo Prasad; Indira K Priyadarsini; Lauren J Webb; Bharat B Aggarwal
Multitargeting by curcumin as revealed by molecular interaction studies.
Natural product reports 2011;28(12):1937-55.
2011: Byoungduck Park; Bokyung Sung; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Biochemical pharmacology 2011;82(9):1134-44.
2011: Kanokkarn Phromnoi; Sahdeo Prasad; Simone Reuter; Subash C Gupta; Ramaswamy Kannappan; Pornngarm Limtrakul; Bharat B Aggarwal
Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.
Molecular pharmacology 2011;80(5):889-99.
2011: Subash C Gupta; Ramaswamy Kannappan; Jihye Kim; Mangalam S Nair; Ghazi M Rahman; Reshma Raveendran; Joydip Das; Sajin K Francis; Bharat B Aggarwal
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Molecular pharmacology 2011;80(5):769-81.
2011: Bokyung Sung; Sung-Gook Cho; Mingyao Liu; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling.
International journal of cancer. Journal international du cancer 2011;129(9):2062-72.
2011: John V Heymach; Ajaikumar B Kunnumakkara; Thomas J Polascik; Mack T Ruffin; Pierre Saintigny; Terry J Shackleford; Denise Clutter Snyder; Hai T Tran; Robin T Vollmer; Melanie Wergin; Shaoyu Yan; Suk-Young Yoo; Bharat B Aggarwal; Mark Dewhirst; Kim-Anh Do; Wendy Demark-Wahnefried
Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.
Cancer prevention research (Philadelphia, Pa.) 2011;4(10):1590-8.
2011: Bharat B Aggarwal; Madan M Chaturvedi; Subash C Gupta; Ramaswamy Kannappan; Ji Hye Kim; Byoungduck Park; Kanokkarn Phromnoi; Sahdeo Prasad; Seema Prasad; Simone Reuter; Chitra Sundaram; Vivek R Yadev; Bokyung Sung
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.
Current drug targets 2011;12(11):1595-653.
2011: Suksanti Prakobwong; Banchob Sripa; Bokyung Sung; Sopit Wongkham; Subash C Gupta; Yusuke Hiraku; Ji Hye Kim; Porntip Pinlaor; Somchai Pinlaor; Bharat B Aggarwal
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.
Carcinogenesis 2011;32(9):1372-80.
2011: Bokyung Sung; Vivek R Yadav; Afsaneh Lavasanifar; Sahdeo Prasad; Bharat B Aggarwal
Cancer and diet: How are they related?
Free radical research 2011;45(8):864-79.
2011: Vivek Narayan; Kodihalli C Ravindra; Bharat B Aggarwal; Daniele Cary; Chris Chiaro; Andrew J Henderson; K Sandeep Prabhu
Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.
Journal of molecular biology 2011;410(5):972-83.
2011: Sahdeo Prasad; Vivek R Yadav; Manoj Pandey; Bharat B Aggarwal
Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.
Cancer prevention research (Philadelphia, Pa.) 2011;4(7):1084-94.
2011: Byoungduck Park; Bokyung Sung; Vivek R Yadav; Sung Gook Cho; Mingyao Liu; Bharat B Aggarwal
Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
International journal of cancer. Journal international du cancer 2011;129(1):23-33.
2011: Masashi Kanai; Yoshiya Kawaguchi; Toshihiko Masui; Shigemi Matsumoto; Yukiko Mori; Takafumi Nishimura; Chihiro Suzuki; Kazuhiro Yanagihara; Shujiro Yazumi; Kenichi Yoshimura; Masanori Asada; Tsutomu Chiba; Sushovan Guha; Atsushi Imaizumi; Bharat B Aggarwal
A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
Cancer chemotherapy and pharmacology 2011;68(1):157-64.
2011: Suksanti Prakobwong; Jarinya Khoontawad; Puangrat Yongvanit; Chawalit Pairojkul; Yusuke Hiraku; Paiboon Sithithaworn; Porntip Pinlaor; Bharat B Aggarwal; Somchai Pinlaor
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
International journal of cancer. Journal international du cancer 2011;129(1):88-100.
2011: Subash C Gupta; Ramaswamy Kannappan; Ji Hye Kim; Simone Reuter; Patrick M Dougherty; Bharat B Aggarwal
Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents.
Experimental biology and medicine (Maywood, N.J.) 2011;236(6):658-71.
2011: Xiufeng Pang; Li Zhang; Li Lai; Jing Chen; Yuanyuan Wu; Zhengfang Yi; Jian Zhang; Weijing Qu; Bharat B Aggarwal; Mingyao Liu
1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway.
Carcinogenesis 2011;32(6):904-12.
2011: Sharon E Campbell; Brittney Rudder; Regenia B Phillips; Sarah Whaley; Julie B Stimmel; Lisa M Leesnitzer; Janet Lightner; Sophie Dessus-Babus; Michelle Duffourc; William Stone; David G Menter; Robert A Newman; Peiying Yang; Bharat B Aggarwal; Koyamangalath Krishnan
γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer.
Free radical biology & medicine 2011;50(10):1344-54.
2011: Simone Reuter; Subash C Gupta; Byoungduck Park; Ajay Goel; Bharat B Aggarwal
Epigenetic changes induced by curcumin and other natural compounds.
Genes & nutrition 2011;6(2):93-108.
2011: Bharat B Aggarwal; Bokyung Sung
The relationship between inflammation and cancer is analogous to that between fuel and fire.
Oncology (Williston Park, N.Y.) 2011;25(5):414-8.
2011: Nobuo Ochi; Suebpong Tanasanvimon; Yoichi Matsuo; Zhimin Tong; Bokyung Sung; Bharat B Aggarwal; James Sinnett-Smith; Enrique Rozengurt; Sushovan Guha
Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells.
Journal of cellular physiology 2011;226(4):1074-81.
2011: Vivek R Yadav; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.
International immunopharmacology 2011;11(3):295-309.
2011: Sahdeo Prasad; Vivek R Yadav; Ramaswamy Kannappan; Bharat B Aggarwal
Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.
The Journal of biological chemistry 2011;286(7):5546-57.
2011: Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Vivek R Yadav; Wisinee Chanmahasathien; Pornngarm Limtrakul; Bharat B Aggarwal
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Molecular pharmacology 2011;79(2):279-89.
2011: Vivek R Yadav; Bharat B Aggarwal
Curcumin: a component of the golden spice, targets multiple angiogenic pathways.
Cancer biology & therapy 2011;11(2):236-41.
2011: Sahdeo Prasad; Vivek R Yadav; Jayaraj Ravindran; Bharat B Aggarwal
ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.
Cancer research 2011;71(2):538-49.
2011: Subash C Gupta; Simone Reuter; Kanokkarn Phromnoi; Byoungduck Park; Padmanabhan S Hema; Mangalam Nair; Bharat B Aggarwal
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
The Journal of biological chemistry 2011;286(2):1134-46.
2011: Byoungduck Park; Sahdeo Prasad; Bokyung Sung; Vivek Yadav; Bharat B Aggarwal
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
PloS one 2011;6(10):e26943.
2011: Subash C Gupta; Ramaswamy Kannappan; Simone Reuter; Ji Hye Kim; Bharat B Aggarwal
Chemosensitization of tumors by resveratrol.
Annals of the New York Academy of Sciences 2011;1215():150-60.
2010: Hareesh B. Nair; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.
Biochemical pharmacology 2010;80(12):1833-43.
2010: Simone Reuter; Subash C Gupta; Madan M Chaturvedi; Bharat B Aggarwal
Oxidative stress, inflammation, and cancer: how are they linked?
Free radical biology & medicine 2010;49(11):1603-16.
2010: Vivek R Yadav; Bokyung Sung; Sahdeo Prasad; Ramaswamy Kannappan; Sung Gook Cho; Mingyao Liu; Madan M Chaturvedi; Bharat B Aggarwal
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Journal of molecular medicine (Berlin, Germany) 2010;88(12):1243-53.
2010: Bharat B Aggarwal; Chitra Sundaram; Seema Prasad; Ramaswamy Kannappan
Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.
Biochemical pharmacology 2010;80(11):1613-31.
2010: Amit K Garg; Anuja Jhingran; Ann H Klopp; Bharat B Aggarwal; Ajai B Kunnumakkara; Russell R Broadus; Patricia J Eifel; Thomas A Buchholz
Expression of nuclear transcription factor kappa B in locally advanced human cervical cancer treated with definitive chemoradiation.
International journal of radiation oncology, biology, physics 2010;78(5):1331-6.
2010: Bokyung Sung; Jayaraj Ravindran; Sahdeo Prasad; Manoj Pandey; Bharat B Aggarwal
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
The Journal of biological chemistry 2010;285(46):35418-27.
2010: Subash C Gupta; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadav; Jayaraj Ravindran; Padmanabhan S Hema; Madan M Chaturvedi; Mangalam Nair; Bharat B Aggarwal
Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
The Journal of biological chemistry 2010;285(46):35406-17.
2010: Simone Reuter; Sahdeo Prasad; Kanokkarn Phromnoi; Jayaraj Ravindran; Bokyung Sung; Vivek R Yadav; Ramaswamy Kannappan; Madan M Chaturvedi; Bharat B Aggarwal
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(11):1462-72.
2010: Ajaikumar Kunnumakkara; Bokyung Sung; Jayaraj Ravindran; Parmeswaran Diagaradjane; Amit Deorukhkar; Sanjit Dey; Cemile Koca; Vivek R Yadav; Zhimin Tong; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
Cancer research 2010;70(21):8695-705.
2010: Mi-Ae Lyu; Bokyung Sung; Lawrence H Cheung; John W Marks; Bharat B Aggarwal; Ricardo Aguiar; Michael G Rosenblum
The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma.
Biochemical pharmacology 2010;80(9):1335-42.
2010: Ramaswamy Kannappan; Vivek R Yadav; Bharat B Aggarwal
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
The Journal of biological chemistry 2010;285(43):33520-8.
2010: Vivek R Yadav; Ramaswamy Kannappan; Sahdeo Prasad; Bokyung Sung; Bharat B Aggarwal
Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
Toxins 2010;2(10):2428-66.
2010: Hong Zhou; Yuying Liu; Lawrence H Cheung; Sehoon Kim; Weihe Zhang; Khalid A Mohamedali; Preetha Anand; Walter N Hittelman; Bharat B Aggarwal; Michael G Rosenblum
Characterization and mechanistic studies of a novel melanoma-targeting construct containing IκBa for specific inhibition of nuclear factor-κB activity.
Neoplasia (New York, N.Y.) 2010;12(10):766-77.
2010: Simone Reuter; Sahdeo Prasad; Kanokkarn Phromnoi; Ramaswamy Kannappan; Vivek R Yadav; Bharat B Aggarwal
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Molecular cancer research : MCR 2010;8(10):1425-36.
2010: Vivek R Yadav; Sahdeo Prasad; Ramaswamy Kannappan; Jayaraj Ravindran; Madan M Chaturvedi; Lauri Vaahtera; Jaakko Parkkinen; Bharat B Aggarwal
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Biochemical pharmacology 2010;80(7):1021-32.
2010: Subash C Gupta; Chitra Sundaram; Simone Reuter; Bharat B Aggarwal
Inhibiting NF-κB activation by small molecules as a therapeutic strategy.
Biochimica et biophysica acta 2010;1799(10-12):775-87.
2010: Mehdi Shakibaei; Bokyung Sung; Gautam Sethi; Bharat B Aggarwal
TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation.
Antioxidants & redox signaling 2010;13(6):821-31.
2010: Kanokkarn Phromnoi; Simone Reuter; Bokyung Sung; Pornngarm Limtrakul; Bharat B Aggarwal
A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.
Anticancer research 2010;30(9):3599-610.
2010: Subash C Gupta; Ji Hye Kim; Sahdeo Prasad; Bharat B Aggarwal
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Cancer metastasis reviews 2010;29(3):405-34.
2010: Sahdeo Prasad; Vivek R Yadav; Chitra Sundaram; Simone Reuter; Padmanabhan S Hema; Mangalam S Nair; Madan M Chaturvedi; Bharat B Aggarwal
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.
The Journal of biological chemistry 2010;285(35):26987-97.
2010: Bharat B Aggarwal
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
Annual review of nutrition 2010;30():173-99.
2010: Yunbao Liu; Vivek R Yadev; Bharat B Aggarwal; Muraleedharan G Nair
Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.
Natural product communications 2010;5(8):1253-7.
2010: Ramaswamy Kannappan; Jayaraj Ravindran; Sahdeo Prasad; Bokyung Sung; Vivek R Yadav; Simone Reuter; Madan M Chaturvedi; Bharat B Aggarwal
Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Molecular cancer therapeutics 2010;9(8):2196-207.
2010: Sahdeo Prasad; Kannokarn Phromnoi; Vivek R Yadav; Madan M Chaturvedi; Bharat B Aggarwal
Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer.
Planta medica 2010;76(11):1044-63.
2010: Chunlei Zhang; Baoqiang Li; Xiang Zhang; Parul Hazarika; Bharat B Aggarwal; Madeleine Duvic
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling.
The Journal of investigative dermatology 2010;130(8):2110-9.
2010: Manoj Pandey; Bokyung Sung; Bharat B Aggarwal
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
International journal of cancer. Journal international du cancer 2010;127(2):282-92.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Gautam Sethi; Parmeswaran Diagaradjane; Preetha Anand; Manoj Pandey; Juri G Gelovani; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.
International journal of cancer. Journal international du cancer 2010;127(2):257-68.
2010: Norleena P Gullett; A R M Ruhul Amin; Soley Bayraktar; John M Pezzuto; Dong M Shin; Fadlo R Khuri; Bharat B Aggarwal; Young-Joon Surh; Omer Kucuk
Cancer prevention with natural compounds.
Seminars in oncology 2010;37(3):258-81.
2010: Varsha Gandhi; Kapil Mehta; Sen Pathak; Balachandran Ravindran; Sandip Mishra; Bharat B Aggarwal
City of temples discusses signaling templates in cancer cells. Third International Symposium on Translational Cancer Research: Cell Signaling & Cancer Therapy. Bhubaneswar, Orissa, India, December 18th through 21st, 2009.
Anticancer research 2010;30(6):2477-80.
2010: Jayaraj Ravindran; Gottumukkala V Subbaraju; Modukuri V Ramani; Bokyung Sung; Bharat B Aggarwal
Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.
Biochemical pharmacology 2010;79(11):1658-66.
2010: Jayaraj Ravindran; Hareesh B. Nair; Bokyung Sung; Sahdeo Prasad; Rajeshwar Tekmal; Bharat B Aggarwal
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
Biochemical pharmacology 2010;79(11):1640-7.
2010: Kuzhuvelil B Harikumar; Bokyung Sung; Sheeja T Tharakan; Manoj Pandey; Beena Joy; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.
Molecular cancer research : MCR 2010;8(5):751-61.
2010: Mi-Ae Lyu; Deepak Rai; Kwang Seok Ahn; Bokyung Sung; Lawrence H Cheung; John W Marks; Bharat B Aggarwal; Ricardo Aguiar; Varsha Gandhi; Michael G Rosenblum
The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo.
Neoplasia (New York, N.Y.) 2010;12(5):366-75.
2010: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Nobuo Ochi; Zhimin Tong; Amit Deorukhkar; Bokyung Sung; Lloyd Kelland; Stephen Jamieson; Rachel Sutherland; Tony Raynham; Mark Charles; Azadeh Bagherzadeh; Azadeh Bagherazadeh; Caroline Foxton; Alexandra Boakes; Muddasar Farooq; Dipen Maru; Parmeswaran Diagaradjane; Yoichi Matsuo; James Sinnett-Smith; Juri G Gelovani; Sunil Krishnan; Bharat B Aggarwal; Enrique Rozengurt; Christopher R Ireson; Sushovan Guha
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
Molecular cancer therapeutics 2010;9(5):1136-46.
2010: Kuzhuvelil B Harikumar; Bokyung Sung; Manoj Pandey; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Molecular pharmacology 2010;77(5):818-27.
2010: Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.
Cancer research 2010;70(8):3259-68.
2010: Bokyung Sung; Byoungduck Park; Vivek R Yadav; Bharat B Aggarwal
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
The Journal of biological chemistry 2010;285(15):11498-507.
2010: Sahdeo Prasad; Jayaraj Ravindran; Bokyung Sung; Manoj K Pandey; Bharat B Aggarwal
Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.
Molecular cancer therapeutics 2010;9(4):856-68.
2010: Xiufeng Pang; Zhengfang Yi; Jing Zhang; Binbin Lu; Bokyung Sung; Weijing Qu; Bharat B Aggarwal; Mingyao Liu
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
Cancer research 2010;70(5):1951-9.
2010: Sahdeo Prasad; Jayaraj Ravindran; Bharat B Aggarwal
NF-kappaB and cancer: how intimate is this relationship.
Molecular and cellular biochemistry 2010;336(1-2):25-37.
2010: Supachai Yodkeeree; Chadarat Ampasavate; Bokyung Sung; Bharat B Aggarwal; Pornngarm Limtrakul
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.
European journal of pharmacology 2010;627(1-3):8-15.
2010: Preetha Anand; Hareesh B. Nair; Bokyung Sung; Ajaikumar Kunnumakkara; Vivek R Yadav; Rajeshwar Tekmal; Bharat B Aggarwal
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.
Biochemical pharmacology 2010;79(3):330-8.
2010: Sheeja T Tharakan; Teruo Inamoto; Bokyung Sung; Bharat B Aggarwal; Ashish M Kamat
Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.
Biochemical pharmacology 2010;79(2):218-28.
2010: Ajay Goel; Bharat B Aggarwal
Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Nutrition and cancer 2010;62(7):919-30.
2010: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Bharat B Aggarwal
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Molecular cancer research : MCR 2010;8(1):107-18.
2010: RAVI ANCHOORI; Kuzhuvelil B Harikumar; Venkateswara Rao Batchu; Bharat B Aggarwal; Saeed R Khan
Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009.
Bioorganic & medicinal chemistry 2010;18(1):229-35.
2009: Ashish M Kamat; Sheeja T Tharakan; Bokyung Sung; Bharat B Aggarwal
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.
Cancer research 2009;69(23):8958-66.
2009: S J Moghaddam; P Barta; S G Mirabolfathinejad; Z Ammar-Aouchiche; N Torres Garza; T T Vo; Robert A Newman; Bharat B Aggarwal; Christopher M Evans; Michael J Tuvim; Reuben Lotan; Burton F Dickey
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Carcinogenesis 2009;30(11):1949-56.
2009: Ajaikumar Kunnumakkara; Parmeswaran Diagaradjane; Preetha Anand; Kuzhuvelil B Harikumar; Harikumar B Kuzhuvelil; Amit Deorukhkar; Juri G Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B Aggarwal
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
International journal of cancer. Journal international du cancer 2009;125(9):2187-97.
2009: Bharat B Aggarwal; Divya Danda; Shan Gupta; Prashasnika Gehlot
Models for prevention and treatment of cancer: problems vs promises.
Biochemical pharmacology 2009;78(9):1083-94.
2009: Santosh K Sandur; Amit Deorukhkar; Manoj Pandey; Ana María Pabón; Shujun Shentu; Sushovan Guha; Bharat B Aggarwal; Sunil Krishnan
Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.
International journal of radiation oncology, biology, physics 2009;75(2):534-42.
2009: Jayaraj Ravindran; Sahdeo Prasad; Bharat B Aggarwal
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
The AAPS journal 2009;11(3):495-510.
2009: Supachai Yodkeeree; Bokyung Sung; Pornngarm Limtrakul; Bharat B Aggarwal
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.
Cancer research 2009;69(16):6581-9.
2009: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Shan R Gupta; Sheeja T Tharakan; Cemile Koca; Sanjit Dey; Bokyung Sung
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.
Annals of the New York Academy of Sciences 2009;1171():59-76.
2009: Bharat B Aggarwal
Inflammation, a silent killer in cancer is not so silent!
Current opinion in pharmacology 2009;9(4):347-50.
2009: Bharat B Aggarwal; Prashasnika Gehlot
Inflammation and cancer: how friendly is the relationship for cancer patients?
Current opinion in pharmacology 2009;9(4):351-69.
2009: Bharat B Aggarwal; Michelle E Van Kuiken; Laxmi H Iyer; Kuzhuvelil B Harikumar; Bokyung Sung
Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.
Experimental biology and medicine (Maywood, N.J.) 2009;234(8):825-49.
2009: Xiufeng Pang; Zhengfang Yi; Xiaoli Zhang; Bokyung Sung; Weijing Qu; Xiaoyuan Lian; Bharat B Aggarwal; Mingyao Liu
Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
Cancer research 2009;69(14):5893-900.
2009: Vanisree Mulabagal; Gottumukkala V Subbaraju; Chirravuri V Rao; Chillara Sivaramakrishna; David L DeWitt; Daniel Holmes; Bokyung Sung; Bharat B Aggarwal; Hsin-Sheng Tsay; Muraleedharan G Nair
Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation.
Phytotherapy research : PTR 2009;23(7):987-92.
2009: Yoichi Matsuo; Paul M Campbell; Rolf A Brekken; Bokyung Sung; Michel M Ouellette; Jason Fleming; Bharat B Aggarwal; Channing J Der; Sushovan Guha
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Molecular cancer research : MCR 2009;7(6):799-808.
2009: Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Preetha Anand; Sushovan Guha; Bharat B Aggarwal
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
Molecular cancer therapeutics 2009;8(4):959-70.
2009: Sri Balasubashini Muralimanoharan; A B Kunnumakkara; Bhaskaran Shylesh; Kaustubh H Kulkarni; Xu Haiyan; Hu Ming; Bharat B Aggarwal; Ghosh Rita; Addanki Kumar
Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells.
The Prostate 2009;69(5):494-504.
2009: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
Molecular pharmacology 2009;75(3):525-33.
2009: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Kwang Seok Ahn; Preetha Anand; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Blood 2009;113(9):2003-13.
2009: Bokyung Sung; Akira Murakami; Babatunde Oyajobi; Bharat B Aggarwal
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice.
Cancer research 2009;69(4):1477-84.
2009: Bharat B Aggarwal; Bokyung Sung
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
Trends in pharmacological sciences 2009;30(2):85-94.
2009: Simone Reuter; Michael Schnekenburger; Silvia Cristofanon; Isabelle Buck; Marie-Hélène Teiten; sandrine daubeuf; Serge Eifes; Mario Dicato; Bharat B Aggarwal; Athanase Visvikis; Marc Diederich
Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.
Biochemical pharmacology 2009;77(3):397-411.
2009: Bharat B Aggarwal; R V Vijayalekshmi; Bokyung Sung
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):425-30.
2009: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Advances in experimental medicine and biology 2009;647():207-15.
2009: Gautam Sethi; Bokyung Sung; Ajaikumar B Kunnumakkara; Bharat B Aggarwal
Targeting TNF for Treatment of Cancer and Autoimmunity.
Advances in experimental medicine and biology 2009;647():37-51.
2009: Vishal Gupta; Abraham Aseh; Carmen N Ríos; Bharat B Aggarwal; Anshu Mathur
Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy.
International journal of nanomedicine 2009;4():115-22.
2009: Ranju Ralhan; Manoj Pandey; Bharat B Aggarwal
Nuclear factor-kappa B links carcinogenic and chemopreventive agents.
Frontiers in bioscience (Scholar edition) 2009;1():45-60.
2009: Ajaikumar B Kunnumakkara; Asha S Nair; Bokyung Sung; Manoj Pandey; Bharat B Aggarwal
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
Molecular cancer research : MCR 2009;7(1):118-28.
2009: Mehdi Shakibaei; Kuzhuvelil B Harikumar; Bharat B Aggarwal
Resveratrol addiction: to die or not to die.
Molecular nutrition & food research 2009;53(1):115-28.
2009: Bharat B Aggarwal; Kuzhuvelil B Harikumar
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
The international journal of biochemistry & cell biology 2009;41(1):40-59.
2008: Preetha Anand; Sherin G Thomas; Ajaikumar Kunnumakkara; Chitra Sundaram; Kuzhuvelil B Harikumar; Bokyung Sung; Sheeja T Tharakan; Krishna Misra; Indira K Priyadarsini; Kallikat N Rajasekharan; Bharat B Aggarwal
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Biochemical pharmacology 2008;76(11):1590-611.
2008: Simone Reuter; Serge Eifes; Mario Dicato; Bharat B Aggarwal; Marc Diederich
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.
Biochemical pharmacology 2008;76(11):1340-51.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Shishir Shishodia; Kuzhuvelil B Harikumar; Suchismita Dass; Krishan G Ramawat; Bharat B Aggarwal
The guggul for chronic diseases: ancient medicine, modern targets.
Anticancer research 2008;28(6A):3647-64.
2008: Bokyung Sung; Sonia Jhurani; Kwang Seok Ahn; Yoichi Mastuo; Tingfang Yi; Sushovan Guha; Mingyao Liu; Bharat B Aggarwal
Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells.
Cancer research 2008;68(21):8938-44.
2008: Preetha Anand; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Kwang Seok Ahn; Vladimir Badmaev; Bharat B Aggarwal
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.
Cancer research 2008;68(21):8861-70.
2008: Kwang Seok Ahn; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2008;123(8):1733-40.
2008: Bharat B Aggarwal
The past, present and future of multi-targeted cancer treatment "naturally": food for thought.
Cancer letters 2008;269(2):187-8.
2008: Ajaikumar Kunnumakkara; Preetha Anand; Bharat B Aggarwal
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Cancer letters 2008;269(2):199-225.
2008: Ajaikumar Kunnumakkara; Haruyo Ichikawa; Preetha Anand; Chiramel J Mohankumar; Padmanabhan S Hema; Mangalam S Nair; Bharat B Aggarwal
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Molecular cancer therapeutics 2008;7(10):3306-17.
2008: Bharat B Aggarwal; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Sheeja T Tharakan; Bokyung Sung; Preetha Anand
Potential of spice-derived phytochemicals for cancer prevention.
Planta medica 2008;74(13):1560-9.
2008: Bharat B Aggarwal
Prostate cancer and curcumin: add spice to your life.
Cancer biology & therapy 2008;7(9):1436-40.
2008: Preetha Anand; Ajaikumar B Kunnumakkara; Ajaikumar B Kunnumakara; Chitra Sundaram; Kuzhuvelil B Harikumar; Sheeja T Tharakan; Oiki S Lai; Bokyung Sung; Bharat B Aggarwal
Cancer is a preventable disease that requires major lifestyle changes.
Pharmaceutical research 2008;25(9):2097-116.
2008: Ajay Goel; Sonia Jhurani; Bharat B Aggarwal
Multi-targeted therapy by curcumin: how spicy is it?
Molecular nutrition & food research 2008;52(9):1010-30.
2008: Preetha Anand; Chitra Sundaram; Sonia Jhurani; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Cancer letters 2008;267(1):133-64.
2008: Zhimin Tong; Ajaikumar Kunnumakkara; Huamin Wang; Yoichi Matsuo; Parmeswaran Diagaradjane; Kuzhuvelil B Harikumar; Vijaya Ramachandran; Bokyung Sung; Arup Chakraborty; Robert S Bresalier; Craig D Logsdon; Bharat B Aggarwal; Sunil Krishnan; Sushovan Guha
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.
Cancer research 2008;68(15):6100-8.
2008: Navneet Dhillon; Bharat B Aggarwal; Robert A Newman; Robert A Wolff; Ajaikumar Kunnumakkara; James L Abbruzzese; Chaan S Ng; Vladimir Badmaev; Razelle Kurzrock
Phase II trial of curcumin in patients with advanced pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(14):4491-9.
2008: Tingfang Yi; Sung Gook Cho; Zhengfang Yi; Xiufeng Pang; Melissa Rodriguez; Ying Wang; Gautam Sethi; Bharat B Aggarwal; Mingyao Liu
Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways.
Molecular cancer therapeutics 2008;7(7):1789-96.
2008: Manoj Pandey; Bokyung Sung; Ajaikumar Kunnumakkara; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research 2008;68(13):5370-9.
2008: Chandra Iyer; Astrid Kosters; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal; James Versalovic
Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
Cellular microbiology 2008;10(7):1442-52.
2008: Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.
Molecular cancer research : MCR 2008;6(6):1059-70.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Bharat B Aggarwal
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Molecular cancer therapeutics 2008;7(6):1604-14.
2008: Kwang Seok Ahn; Gautam Sethi; Bokyung Sung; Ajay Goel; Ranju Ralhan; Bharat B Aggarwal
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Cancer research 2008;68(11):4406-15.
2008: Bokyung Sung; Manoj Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.
Blood 2008;111(10):4880-91.
2008: Yasunari Takada; Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Molecular pharmacology 2008;73(5):1549-57.
2008: Kuzhuvelil B Harikumar; Bharat B Aggarwal
Resveratrol: a multitargeted agent for age-associated chronic diseases.
Cell cycle (Georgetown, Tex.) 2008;7(8):1020-35.
2008: Amit Verma; Sushovan Guha; Parmeswaran Diagaradjane; Ajaikumar Kunnumakkara; Angela M Sanguino; Gabriel Lopez-Berestein; Anil K Sood; Bharat B Aggarwal; Sunil Krishnan; Juri G Gelovani; Kapil Mehta
Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2476-83.
2008: Ajaikumar Kunnumakkara; Parmeswaran Diagaradjane; Sushovan Guha; Amit Deorukhkar; Shujun Shentu; Bharat B Aggarwal; Sunil Krishnan
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2128-36.
2008: Tingfang Yi; Zhengfang Yi; Sung Gook Cho; Jian Luo; Manoj Pandey; Bharat B Aggarwal; Mingyao Liu
Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.
Cancer research 2008;68(6):1843-50.
2008: Georges Herbein; Audrey Varin; Anis Larbi; Carl Fortin; Ulrich Mahlknecht; Tamas Fulop; Bharat B Aggarwal
Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages.
Current HIV research 2008;6(2):117-29.
2008: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.
Biochemical pharmacology 2008;75(4):907-13.
2008: Ajay Goel; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Curcumin as "Curecumin": from kitchen to clinic.
Biochemical pharmacology 2008;75(4):787-809.
2008: Hiroko Shibata; Yasuo Yoshioka; Akiko Ohkawa; Kyoko Minowa; Yohei Mukai; Yasuhiro Abe; Madoka Taniai; Tetsuya Nomura; Hiroyuki Kayamuro; Hiromi Nabeshi; Toshiki Sugita; Sunao Imai; Kazuya Nagano; Tomoaki Yoshikawa; Takuya Fujita; Shinsaku Nakagawa; Akira Yamamoto; Tsunetaka Ohta; Takao Hayakawa; Tadanori Mayumi; Peter Vandenabeele; Bharat B Aggarwal; Teruya Nakamura; Yuriko Yamagata; Shin-ichi Tsunoda; Haruhiko Kamada; Yasuo Tsutsumi
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
The Journal of biological chemistry 2008;283(2):998-1007.
2008: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
TNF: a master switch for inflammation to cancer.
Frontiers in bioscience : a journal and virtual library 2008;13():5094-107.
2008: Bokyung Sung; Manoj Pandey; Yuki Nakajima; Hiroshi Nishida; Tetsuya Konishi; Madan M Chaturvedi; Bharat B Aggarwal
Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.
Molecular cancer therapeutics 2008;7(1):191-201.
2008: Gautam Sethi; Bokyung Sung; Bharat B Aggarwal
Nuclear factor-kappaB activation: from bench to bedside.
Experimental biology and medicine (Maywood, N.J.) 2008;233(1):21-31.
2007: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Gautam Sethi; Kwang Seok Ahn; Madan M Chaturvedi; Bharat B Aggarwal
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Oncogene 2007;26(52):7324-32.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Nuclear factor-kappa B: from clone to clinic.
Current molecular medicine 2007;7(7):619-37.
2007: Preetha Anand; Ajaikumar Kunnumakkara; Robert A Newman; Bharat B Aggarwal
Bioavailability of curcumin: problems and promises.
Molecular pharmaceutics 2007;4(6):807-18.
2007: Amit Deorukhkar; Sunil Krishnan; Gautam Sethi; Bharat B Aggarwal
Back to basics: how natural products can provide the basis for new therapeutics.
Expert opinion on investigational drugs 2007;16(11):1753-73.
2007: Urs von Holzen; Abujiang Pataer; Uma Raju; Dora Bocangel; Stephan A Vorburger; Yanna Liu; Xiaolin Lu; Jack A Roth; Bharat B Aggarwal; Glen N Barber; Khandan Keyomarsi; Kelly K Hunt; Stephen G Swisher
The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6032-9.
2007: Kwang Seok Ahn; Xing Gong; Gautam Sethi; Madan M Chaturvedi; Anil K Jaiswal; Bharat B Aggarwal
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Cancer research 2007;67(20):10004-11.
2007: Bharat B Aggarwal; Gautam Sethi; Veera Baladandayuthapani; Sunil Krishnan; Shishir Shishodia
Targeting cell signaling pathways for drug discovery: an old lock needs a new key.
Journal of cellular biochemistry 2007;102(3):580-92.
2007: Yasunari Takada; Bokyung Sung; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.
Biochemical pharmacology 2007;74(7):1057-64.
2007: Kwang Seok Ahn; Gautam Sethi; Ta-Hsiang Chao; Saskia T C Neuteboom; Madan M Chaturvedi; Michael A Palladino; Anas Younes; Bharat B Aggarwal
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood 2007;110(7):2286-95.
2007: Ashutosh K Pathak; Manisha Bhutani; Asha S Nair; Kwang Seok Ahn; Arup Chakraborty; Humam Kadara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Molecular cancer research : MCR 2007;5(9):943-55.
2007: Santosh K Sandur; Haruyo Ichikawa; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Gautam Sethi; Bharat B Aggarwal
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Free radical biology & medicine 2007;43(4):568-80.
2007: Gautam Sethi; Kwang Seok Ahn; Dianren Xia; Jonathan M Kurie; Bharat B Aggarwal
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1926-33.
2007: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Akira Murakami; Gautam Sethi; Pornngarm Limtrakul; Vladimir Badmaev; Bharat B Aggarwal
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Carcinogenesis 2007;28(8):1765-73.
2007: Gautam Sethi; Bharat B Aggarwal
Mending the bones with natural products.
Chemistry & biology 2007;14(7):738-40.
2007: Shishir Shishodia; Madan M Chaturvedi; Bharat B Aggarwal
Role of curcumin in cancer therapy.
Current problems in cancer 2007;31(4):243-305.
2007: Hiroshi Aoki; Yasunari Takada; Seiji Kondo; Raymond Sawaya; Bharat B Aggarwal; Yasuko Kondo
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Molecular pharmacology 2007;72(1):29-39.
2007: Shishir Shishodia; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Biochemical pharmacology 2007;74(1):118-30.
2007: Laura Bover; Marina Cardó-Vila; Akihiko Kuniyasu; Jessica Sun; Roberto Rangel; Motohiro Takeya; Bharat B Aggarwal; Wadih Arap; Renata Pasqualini
A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8183-94.
2007: Manoj Pandey; Santosh K Sandur; Bokyung Sung; Gautam Sethi; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
The Journal of biological chemistry 2007;282(24):17340-50.
2007: Meenakshi Sawhney; Nidhi Rohatgi; Jatinder Kaur; Shishir Shishodia; Gautam Sethi; S Datta Gupta; S V S Deo; Nootan K Shukla; Bharat B Aggarwal; Ranju Ralhan
Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco.
International journal of cancer. Journal international du cancer 2007;120(12):2545-56.
2007: Ajaikumar Kunnumakkara; Asha S Nair; Kwang Seok Ahn; Manoj Pandey; Zhengfang Yi; Mingyao Liu; Bharat B Aggarwal
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Blood 2007;109(12):5112-21.
2007: Yvonne G Lin; Ajaikumar Kunnumakkara; Asha Nair; William M Merritt; Liz Y Han; Guillermo N Armaiz-Pena; Aparna A Kamat; Whitney A Spannuth; David M Gershenson; Susan K Lutgendorf; Bharat B Aggarwal; Anil K Sood
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3423-30.
2007: Dinesh Khanna; Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Amita Aggarwal; Bharat B Aggarwal
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Bokyung Sung; Manoj Pandey; Bharat B Aggarwal
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
Molecular pharmacology 2007;71(6):1703-14.
2007: Dimpy Koul; Ruijun Shen; Shishir Shishodia; Yasanuri Takada; Krishna P Bhat; Shrikanth A G Reddy; Bharat B Aggarwal; W K Alfred Yung
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Molecular and cellular biochemistry 2007;300(1-2):77-87.
2007: Manisha Bhutani; Ashutosh K Pathak; Asha S Nair; Ajaikumar Kunnumakkara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3024-32.
2007: Ajaikumar Kunnumakkara; Sushovan Guha; Sunil Krishnan; Parmeswaran Diagaradjane; Juri G Gelovani; Bharat B Aggarwal
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Cancer research 2007;67(8):3853-61.
2007: Julie G Izzo; Rajyalakshmi Luthra; Tsung-Teh Wu; Arlene M Correa; Madan G Luthra; Sharmila Anandasabapathy; K.S. Chao; Mien-Chie Hung; Bharat B Aggarwal; Walter N Hittelman; Jaffer A Ajani
Molecular mechanisms in Barrett's metaplasia and its progression.
Seminars in oncology 2007;34(2 Suppl 1):S2-6.
2007: Sunil K Manna; Rishi S Aggarwal; Gautam Sethi; Bharat B Aggarwal; Govindarajan T Ramesh
Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2290-7.
2007: Bharat B Aggarwal; Sanjeev Banerjee; Uddalak Bharadwaj; Bokyung Sung; Shishir Shishodia; Gautam Sethi
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.
Biochemical pharmacology 2007;73(7):1024-32.
2007: Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Bharat B Aggarwal
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
Blood 2007;109(7):2727-35.
2007: Anjana Bhardwaj; Gautam Sethi; Saroj Vadhan-Raj; Carlos E Bueso-Ramos; Yasunari Takada; Upasna Gaur; Asha S Nair; Shishir Shishodia; Bharat B Aggarwal
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Blood 2007;109(6):2293-302.
2007: Ashish M Kamat; Gautam Sethi; Bharat B Aggarwal
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.
Molecular cancer therapeutics 2007;6(3):1022-30.
2007: D G Jackson-Bernitsas; Haruyo Ichikawa; Yasunari Takada; Jeffrey N Myers; X L Lin; Bryant G Darnay; Madan M Chaturvedi; Bharat B Aggarwal
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Oncogene 2007;26(10):1385-97.
2007: Yasunari Takada; Haruyo Ichikawa; Abujiang Pataer; Stephen G Swisher; Bharat B Aggarwal
Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
Oncogene 2007;26(8):1201-12.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2507-16.
2007: Dianren Xia; Harish Srinivas; Young-Ho Ahn; Gautam Sethi; Xiaoyang Sheng; W K Alfred Yung; Qianghua Xia; Paul J Chiao; Heetae Kim; Powel H Brown; Ignacio I Wistuba; Bharat B Aggarwal; Jonathan M Kurie
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.
The Journal of biological chemistry 2007;282(6):3507-19.
2007: Bharat B Aggarwal
Nuclear factor-kappa B: a transcription factor for all seasons.
Expert opinion on therapeutic targets 2007;11(2):109-10.
2007: Kwang Seok Ahn; Gautam Sethi; Koyamangalath Krishnan; Bharat B Aggarwal
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
The Journal of biological chemistry 2007;282(1):809-20.
2007: Haruyo Ichikawa; Yutaka Nakamura; Yoshiki Kashiwada; Bharat B Aggarwal
Anticancer drugs designed by mother nature: ancient drugs but modern targets.
Current pharmaceutical design 2007;13(33):3400-16.
2007: Bharat B Aggarwal; Chitra Sundaram; Nikita Malani; Haruyo Ichikawa
Curcumin: the Indian solid gold.
Advances in experimental medicine and biology 2007;595():1-75.
2007: Santosh K Sandur; Kwang Seok Ahn; Haruyo Ichikawa; Gautam Sethi; Shishir Shishodia; Robert A Newman; Bharat B Aggarwal
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
Nutrition and cancer 2007;57(1):78-87.
2007: Prachi Garodia; Haruyo Ichikawa; Nikita Malani; Gautam Sethi; Bharat B Aggarwal
From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.
Journal of the Society for Integrative Oncology 2007;5(1):25-37.
2007: Ganesh Chandra Jagetia; Bharat B Aggarwal
"Spicing up" of the immune system by curcumin.
Journal of clinical immunology 2007;27(1):19-35.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology 2007;71(1):209-19.
2006: Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Ximing Tang; Diane Liu; Shishir Shishodia; Natalie Ozburn; Carmen Behrens; J Jack Lee; Waun Ki Hong; Bharat B Aggarwal; Ignacio I Wistuba
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Cancer 2006;107(11):2637-46.
2006: Kapil Mehta; V Gandhi; Bharat B Aggarwal
All pathways to cancer apoptosis meeting in Thiruvananthapuram (India).
Cell death and differentiation 2006;13(12):2163-4.
2006: Bharat B Aggarwal; Shishir Shishodia; Santosh K Sandur; Manoj Pandey; Gautam Sethi
Inflammation and cancer: how hot is the link?
Biochemical pharmacology 2006;72(11):1605-21.
2006: Dimpy Koul; Yasunari Takada; Ruijun Shen; Bharat B Aggarwal; W K Alfred Yung
PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.
Biochemical and biophysical research communications 2006;350(2):463-71.
2006: Chavvi Sharma; Jatinder Kaur; Shishir Shishodia; Bharat B Aggarwal; Ranju Ralhan
Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.
Toxicology 2006;228(1):1-15.
2006: Rajesh Agarwal; Chapla Agarwal; Haruyo Ichikawa; Rana Singh; Bharat B Aggarwal
Anticancer potential of silymarin: from bench to bed side.
Anticancer research 2006;26(6B):4457-98.
2006: Julie G Izzo; Arlene M Correa; Tsung-Teh Wu; Usha Malhotra; K.S. Chao; Rajyalakshmi Luthra; Joe Ensor; Alexander Dekovich; Zhongxing Liao; Walter N Hittelman; Bharat B Aggarwal; Jaffer A Ajani
Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma.
Molecular cancer therapeutics 2006;5(11):2844-50.
2006: Ajit Zambre; Vithal M Kulkarni; Subhash Padhye; Santosh K Sandur; Bharat B Aggarwal
Novel curcumin analogs targeting TNF-induced NF-kappaB activation and proliferation in human leukemic KBM-5 cells.
Bioorganic & medicinal chemistry 2006;14(21):7196-204.
2006: Asha S Nair; Shishir Shishodia; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Gautam Sethi; Bharat B Aggarwal
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5612-22.
2006: Haruyo Ichikawa; Mangalam S Nair; Yasunari Takada; D B Alan Sheeja; M A Suresh Kumar; Oommen V Vilaverthottathil Oommen; Bharat B Aggarwal
Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5910-8.
2006: Nitin Chakravarti; Jeffrey N Myers; Bharat B Aggarwal
Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).
International journal of cancer. Journal international du cancer 2006;119(6):1268-75.
2006: Kwang Seok Ahn; Gautam Sethi; Shishir Shishodia; Bokyung Sung; Jack L Arbiser; Bharat B Aggarwal
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Molecular cancer research : MCR 2006;4(9):621-33.
2006: Aman P Mann; Amit Verma; Gautam Sethi; Bramanandam Manavathi; Huamin Wang; Jansina Y Fok; Ajaikumar Kunnumakkara; Rakesh Kumar; Bharat B Aggarwal; Kapil Mehta
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
Cancer research 2006;66(17):8788-95.
2006: Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Xin Lin; Madan M Chaturvedi; Bharat B Aggarwal
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
The Journal of biological chemistry 2006;281(33):23425-35.
2006: Kwang Seok Ahn; Gautam Sethi; Abhinav K Jain; Anil K Jaiswal; Bharat B Aggarwal
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
The Journal of biological chemistry 2006;281(29):19798-808.
2006: Santosh K Sandur; Haruyo Ichikawa; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
The Journal of biological chemistry 2006;281(25):17023-33.
2006: Haruyo Ichikawa; Yasunari Takada; Shishir Shishodia; Bolleddula Jayaprakasam; Muraleedharan G Nair; Bharat B Aggarwal
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.
Molecular cancer therapeutics 2006;5(6):1434-45.
2006: Bharat B Aggarwal; Shishir Shishodia
Molecular targets of dietary agents for prevention and therapy of cancer.
Biochemical pharmacology 2006;71(10):1397-421.
2006: Haruyo Ichikawa; Akira Murakami; Bharat B Aggarwal
1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation.
Molecular cancer research : MCR 2006;4(4):275-81.
2006: Shishir Shishodia; Gautam Sethi; Marina Konopleva; Michael Andreeff; Bharat B Aggarwal
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1828-38.
2006: Shishir Shishodia; Bharat B Aggarwal
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression.
Oncogene 2006;25(10):1463-73.
2006: Yasunari Takada; Ann M Gillenwater; Haruyo Ichikawa; Bharat B Aggarwal
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
The Journal of biological chemistry 2006;281(9):5612-22.
2006: Yasunari Takada; Haruyo Ichikawa; Vladimir Badmaev; Bharat B Aggarwal
Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3127-40.
2006: Julie G Izzo; Usha Malhotra; Tsung-Teh Wu; Joe Ensor; Rajyalakshmi Luthra; Jeffrey H Lee; Stephen G Swisher; Zhongxing Liao; K.S. Chao; Walter N Hittelman; Bharat B Aggarwal; Jaffer A Ajani
Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(5):748-54.
2006: Lynn S Adams; Navindra P Seeram; Bharat B Aggarwal; Yasunari Takada; Daniel Sand; David Heber
Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.
Journal of agricultural and food chemistry 2006;54(3):980-5.
2006: Bharat B Aggarwal; Haruyo Ichikawa; Prachi Garodia; Priya Weerasinghe; Gautam Sethi; Indra D Bhatt; Manoj Pandey; Shishir Shishodia; Muraleedharan G Nair
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.
Expert opinion on therapeutic targets 2006;10(1):87-118.
2006: Haruyo Ichikawa; Bharat B Aggarwal
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):662-8.
2006: Anthony P Gulati; Yang-Ming Yang; David H Harter; Asok Mukhopadhyay; Bharat B Aggarwal; Bharat A Aggarwal; Deborah L Benzil; John Whysner; Anthony P Albino; Raj Murali; Meena Jhanwar-Uniyal
Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.
Molecular carcinogenesis 2006;45(1):26-37.
2006: Sita Aggarwal; Haruyo Ichikawa; Yasunari Takada; Santosh K Sandur; Shishir Shishodia; Bharat B Aggarwal
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Molecular pharmacology 2006;69(1):195-206.
2005: Audrey Varin; Anne-Zélie Decrion; Emmanuelle N Sabbah; Vincent Quivy; Joséphine Sire; Carine Van Lint; Bernard P Roques; Bharat B Aggarwal; Georges Herbein
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
The Journal of biological chemistry 2005;280(52):42557-67.
2005: Thomas Buchholz; Amit K Garg; Nitin Chakravarti; Bharat B Aggarwal; Francisco J Esteva; Henry M Kuerer; S Eva Singletary; Gabriel N Hortobagyi; Lajos Pusztai; Massimo Cristofanilli; Aysegul A Sahin
The nuclear transcription factor kappaB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(23):8398-402.
2005: Kwang Seok Ahn; Bharat B Aggarwal
Transcription factor NF-kappaB: a sensor for smoke and stress signals.
Annals of the New York Academy of Sciences 2005;1056():218-33.
2005: Shishir Shishodia; Gautam Sethi; Bharat B Aggarwal
Curcumin: getting back to the roots.
Annals of the New York Academy of Sciences 2005;1056():206-17.
2005: Amit K Garg; Thomas Buchholz; Bharat B Aggarwal
Chemosensitization and radiosensitization of tumors by plant polyphenols.
Antioxidants & redox signaling 2005;7(11-12):1630-47.
2005: Yasunari Takada; Akira Murakami; Bharat B Aggarwal
Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.
Oncogene 2005;24(46):6957-69.
2005: Bharat B Aggarwal; Shishir Shishodia; Yasunari Takada; Sanjeev Banerjee; Robert A Newman; Carlos E Bueso-Ramos; Janet E Price
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(20):7490-8.
2005: Shishir Shishodia; Angelica M Gutierrez; Reuben Lotan; Bharat B Aggarwal
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
Cancer research 2005;65(20):9555-65.
2005: Bharat B Aggarwal; Haruyo Ichikawa
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Cell cycle (Georgetown, Tex.) 2005;4(9):1201-15.
2005: Shishir Shishodia; Hesham M Amin; Raymond Lai; Bharat B Aggarwal
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
Biochemical pharmacology 2005;70(5):700-13.
2005: Doris R Siwak; Shishir Shishodia; Bharat B Aggarwal; Razelle Kurzrock
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.
Cancer 2005;104(4):879-90.
2005: Yasunari Takada; Michael Andreeff; Bharat B Aggarwal
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Blood 2005;106(2):641-9.
2005: M Amit-Vazina; Shishir Shishodia; David Harris; Quin Van; Michael Wang; Donna Weber; Raymond Alexanian; Moshe Talpaz; Bharat B Aggarwal; Zeev Estrov
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells.
British journal of cancer 2005;93(1):70-80.
2005: Haruyo Ichikawa; Yasunari Takada; Akira Murakami; Bharat B Aggarwal
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7383-92.
2005: Yasunari Takada; Yoshinori Kobayashi; Bharat B Aggarwal
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
The Journal of biological chemistry 2005;280(17):17203-12.
2005: Mehdi Shakibaei; Gundula Schulze-Tanzil; Yasunari Takada; Bharat B Aggarwal
Redox regulation of apoptosis by members of the TNF superfamily.
Antioxidants & redox signaling 2005;7(3-4):482-96.
2005: Chunhong Yan; Md Saha Jamaluddin; Bharat B Aggarwal; Jeffrey L Myers; Douglas D Boyd
Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.
Molecular cancer therapeutics 2005;4(2):233-41.
2005: Bharat B Aggarwal; Yasunari Takada
Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-kappaB.
Cancer treatment and research 2005;126():103-27.
2005: Alok C Bharti; Yasunari Takada; Bharat B Aggarwal
PARP cleavage and caspase activity to assess chemosensitivity.
Methods in molecular medicine 2005;111():69-78.
2004: Yasunari Takada; Bharat B Aggarwal
Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling.
Blood 2004;104(13):4113-21.
2004: Yasunari Takada; Anjana Bhardwaj; Pravin Potdar; Bharat B Aggarwal
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.
Oncogene 2004;23(57):9247-58.
2004: Bharat B Aggarwal; Shishir Shishodia
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Annals of the New York Academy of Sciences 2004;1030():434-41.
2004: Thambi Dorai; Bharat B Aggarwal
Role of chemopreventive agents in cancer therapy.
Cancer letters 2004;215(2):129-40.
2004: Lan Li; Bharat B Aggarwal; Shishir Shishodia; James L Abbruzzese; Razelle Kurzrock
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.
Cancer 2004;101(10):2351-62.
2004: Shishir Shishodia; Bharat B Aggarwal
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
The Journal of biological chemistry 2004;279(45):47148-58.
2004: Bharat B Aggarwal; Yasunari Takada; Oommen V Vilaverthottathil Oommen
From chemoprevention to chemotherapy: common targets and common goals.
Expert opinion on investigational drugs 2004;13(10):1327-38.
2004: Sita Aggarwal; Yasunari Takada; Abner M Mhashilkar; Kerry Sieger; Sunil Chada; Bharat B Aggarwal
Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4368-76.
2004: Sita Aggarwal; Yasunari Takada; Sujay Singh; Jeffrey N Myers; Bharat B Aggarwal
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.
International journal of cancer. Journal international du cancer 2004;111(5):679-92.
2004: Yasunari Takada; Xianjun Fang; Md Saha Jamaluddin; Douglas D Boyd; Bharat B Aggarwal
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 2004;279(38):39541-54.
2004: Shishir Shishodia; Bharat B Aggarwal
Nuclear factor-kappaB: a friend or a foe in cancer?
Biochemical pharmacology 2004;68(6):1071-80.
2004: Cristi L Galindo; Amin A Fadl; Jian Sha; Celso Gutierrez; Vsevolod L Popov; Istvan Boldogh; Bharat B Aggarwal; Ashok K Chopra
Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells.
The Journal of biological chemistry 2004;279(36):37597-612.
2004: Bharat B Aggarwal; Anjana Bhardwaj; Rishi S Aggarwal; Navindra P Seeram; Shishir Shishodia; Yasunari Takada
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Anticancer research 2004;24(5A):2783-840.
2004: Bharat B Aggarwal
Nuclear factor-kappaB: the enemy within.
Cancer cell 2004;6(3):203-8.
2004: Shishir Shishodia; Dimpy Koul; Bharat B Aggarwal
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2011-22.
2004: Shishir Shishodia; Bharat B Aggarwal
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.
Cancer research 2004;64(14):5004-12.
2004: Yasunari Takada; Bharat B Aggarwal
TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1066-77.
2004: Ashok Kumar; Yasunari Takada; Aladin M Boriek; Bharat B Aggarwal
Nuclear factor-kappaB: its role in health and disease.
Journal of molecular medicine (Berlin, Germany) 2004;82(7):434-48.
2004: Yasunari Takada; Fadlo R Khuri; Bharat B Aggarwal
Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
The Journal of biological chemistry 2004;279(25):26287-99.
2004: Alok C Bharti; Yasunari Takada; Bharat B Aggarwal
Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5940-7.
2004: Bei Zheng; Georgios V Georgakis; Yang Li; Alok C Bharti; David J McConkey; Bharat B Aggarwal; Anas Younes
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3207-15.
2004: Devasis Chatterjee; Yin Bai; zhe wang; Sandy Beach; Stephanie Mott; Rajat Roy; Corey D Braastad; Yaping Sun; Asok Mukhopadhyay; Bharat B Aggarwal; James W Darnowski; Panayotis Pantazis; James H Wyche; Zheng Fu; Yasuhide Kitagwa; Evan T Keller; John M Sedivy; Kam C Yeung
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis.
The Journal of biological chemistry 2004;279(17):17515-23.
2004: Alok C Bharti; Shishir Shishodia; James M Reuben; Donna Weber; Raymond Alexanian; Saroj Raj-Vadhan; Zeev Estrov; Moshe Talpaz; Bharat B Aggarwal
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis.
Blood 2004;103(8):3175-84.
2004: Yasunari Takada; Sujay Singh; Bharat B Aggarwal
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
The Journal of biological chemistry 2004;279(15):15096-104.
2004: Bharat B Aggarwal; Yasunari Takada; Shishir Shishodia; Angelica M Gutierrez; Oommen V Vilaverthottathil Oommen; Haruyo Ichikawa; Yuh Baba; Ashok Kumar
Nuclear transcription factor NF-kappa B: role in biology and medicine.
Indian journal of experimental biology 2004;42(4):341-53.
2004: Xianjun Fang; Shuangxing Yu; Robert C Bast; Shuying Liu; Hong-Ji Xu; Shi-Xue Hu; Ruth Lapushin; Francois Claret; Bharat B Aggarwal; Yiling Lu; Gordon B Mills
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2004: Chunhong Yan; Heng Wang; Bharat B Aggarwal; Douglas D Boyd
A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):540-1.
2004: Alok C Bharti; Yasunari Takada; Shishir Shishodia; Bharat B Aggarwal
Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism.
The Journal of biological chemistry 2004;279(7):6065-76.
2004: Yasunari Takada; Bharat B Aggarwal
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
The Journal of biological chemistry 2004;279(6):4750-9.
2004: Carlos E Bueso-Ramos; Frederico C Rocha; Shishir Shishodia; L Jeffrey Medeiros; Hagop M Kantarjian; Saroj Vadhan-Raj; Zeev Estrov; Terry L Smith; Martin H Nguyen; Bharat B Aggarwal
Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia.
Human pathology 2004;35(2):246-53.
2004: Nicholas J Donato; Ji Y Wu; Jonathan Stapley; Hui Lin; Ralph B Arlinghaus; Bharat B Aggarwal; Shishir Shishodia; Maher Albitar; Kimberly Hayes; Andrew Lamb; Moshe Talpaz; Shishir Shishodin
Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia.
Cancer research 2004;64(2):672-7.
2004: Kazuhiro Ashikawa; Shishir Shishodia; Izabela Fokt; Waldemar Priebe; Bharat B Aggarwal
Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues.
Biochemical pharmacology 2004;67(2):353-64.
2004: Shishir Shishodia; Bharat B Aggarwal
Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer.
Cancer treatment and research 2004;119():139-73.
2004: Bharat B Aggarwal; Uddalak Bhardwaj; Yasunari Takada
Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors.
Vitamins and hormones 2004;67():453-83.
2003: Amit K Garg; Gabriel N Hortobagyi; Bharat B Aggarwal; Aysegul A Sahin; Thomas Buchholz
Nuclear factor-kappa B as a predictor of treatment response in breast cancer.
Current opinion in oncology 2003;15(6):405-11.
2003: M P Thompson; Bharat B Aggarwal; S Shishodia; Zeev Estrov; Razelle Kurzrock
Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells: induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1.
Leukemia 2003;17(11):2196-201.
2003: Upasna Gaur; Bharat B Aggarwal
Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.
Biochemical pharmacology 2003;66(8):1403-8.
2003: Alok C Bharti; Nicholas J Donato; Bharat B Aggarwal
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3863-71.
2003: Yasunari Takada; Bharat B Aggarwal
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3278-86.
2003: Anjana Bhardwaj; Bharat B Aggarwal
Receptor-mediated choreography of life and death.
Journal of clinical immunology 2003;23(5):317-32.
2003: Bharat B Aggarwal
Signalling pathways of the TNF superfamily: a double-edged sword.
Nature reviews. Immunology 2003;3(9):745-56.
2003: Shishir Shishodia; Sekhar Majumdar; Sanjeev Banerjee; Bharat B Aggarwal
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Cancer research 2003;63(15):4375-83.
2003: Zeev Estrov; Shishir Shishodia; Stefan Faderl; David Harris; Quin Van; Hagop M Kantarjian; Moshe Talpaz; Bharat B Aggarwal
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.
Blood 2003;102(3):987-95.
2003: Shishir Shishodia; Pravin Potdar; C Gary Gairola; Bharat B Aggarwal
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.
Carcinogenesis 2003;24(7):1269-79.
2003: Yasunari Takada; Asok Mukhopadhyay; Gopal C Kundu; Ganapati H Mahabeleshwar; Sujay Singh; Bharat B Aggarwal
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.
The Journal of biological chemistry 2003;278(26):24233-41.
2003: Yasunari Takada; Bharat B Aggarwal
Genetic deletion of the tumor necrosis factor receptor p60 or p80 sensitizes macrophages to lipopolysaccharide-induced nuclear factor-kappa B, mitogen-activated protein kinases, and apoptosis.
The Journal of biological chemistry 2003;278(26):23390-7.
2003: Anas Younes; Amit Garg; Bharat B Aggarwal
Nuclear transcription factor-kappaB in Hodgkin's disease.
Leukemia & lymphoma 2003;44(6):929-35.
2003: Sekhar Majumdar; Bharat B Aggarwal
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Oncogene 2003;22(8):1206-18.
2003: Sunil K Manna; Carlos E Bueso-Ramos; Francisco Alvarado; Bharat B Aggarwal
Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents.
Cancer letters 2003;190(2):171-82.
2003: Alok C Bharti; Nicholas J Donato; Sujay Singh; Bharat B Aggarwal
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Blood 2003;101(3):1053-62.
2003: Audrey Varin; Sunil K Manna; Vincent Quivy; Anne-Zélie Decrion; Carine Van Lint; Georges Herbein; Bharat B Aggarwal
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis.
The Journal of biological chemistry 2003;278(4):2219-27.
2003: Bharat B Aggarwal; Anushree Kumar; Alok C Bharti
Anticancer potential of curcumin: preclinical and clinical studies.
Anticancer research 2003;23(1A):363-98.
2002: Asok Mukhopadhyay; Sanjeev Banerjee; Lewis Joe Stafford; Chunzhi Xia; Mingyao Liu; Bharat B Aggarwal
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Oncogene 2002;21(57):8852-61.
2002: Bharat B Aggarwal; Shishir Shishodia; Kazuhiro Ashikawa; Alok C Bharti
The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.
Current drug targets. Inflammation and allergy 2002;1(4):327-41.
2002: Masahiro Higuchi; Sunil K Manna; Ryouhei Sasaki; Bharat B Aggarwal
Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways.
Antioxidants & redox signaling 2002;4(6):945-55.
2002: Kazuhiro Ashikawa; Sekhar Majumdar; Sanjeev Banerjee; Alok C Bharti; Shishir Shishodia; Bharat B Aggarwal
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6490-7.
2002: Amit K Garg; Bharat B Aggarwal
Reactive oxygen intermediates in TNF signaling.
Molecular immunology 2002;39(9):509-17.
2002: Alok C Bharti; Bharat B Aggarwal
Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization.
Annals of the New York Academy of Sciences 2002;973():392-5.
2002: Alok C Bharti; Bharat B Aggarwal
Nuclear factor-kappa B and cancer: its role in prevention and therapy.
Biochemical pharmacology 2002;64(5-6):883-8.
2002: Sanjeev Banerjee; Carlos E Bueso-Ramos; Bharat B Aggarwal
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.
Cancer research 2002;62(17):4945-54.
2002: Ruby John Anto; Asok Mukhopadhyay; Shishir Shishodia; C Gary Gairola; Bharat B Aggarwal
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Carcinogenesis 2002;23(9):1511-8.
2002: Kota V Ramana; Deepak Chandra; Sanjay Srivastava; Aruni Bhatnagar; Bharat B Aggarwal; Satish K Srivastava
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(35):32063-70.
2002: Asok Mukhopadhyay; Shishir Shishodia; Jill Suttles; Katherine C Brittingham; Betty Lamothe; Ramadevi Nimmanapalli; Kapil N Bhalla; Bharat B Aggarwal
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.
The Journal of biological chemistry 2002;277(34):30622-8.
2002: Shaan M Raza; Frederick F Lang; Bharat B Aggarwal; Gregory N Fuller; David M Wildrick; Raymond Sawaya
Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis.
Neurosurgery 2002;51(1):2-12; discussion 12-3.
2002: A Garg; Bharat B Aggarwal
Nuclear transcription factor-kappaB as a target for cancer drug development.
Leukemia 2002;16(6):1053-68.
2002: Sekhar Majumdar; Betty Lamothe; Bharat B Aggarwal
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2644-51.
2002: Betty Lamothe; Bharat B Aggarwal
Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(2):269-79.
2002: Shishir Shishodia; Bharat B Aggarwal
Nuclear factor-kappaB activation: a question of life or death.
Journal of biochemistry and molecular biology 2002;35(1):28-40.
2002: Asok Mukhopadhyay; Shishir Shishodia; Xin-Yuan Fu; Bharat B Aggarwal
Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha.
Journal of cellular biochemistry 2002;84(4):803-15.
2002: Ruby John Anto; Asok Mukhopadhyay; Kate Denning; Bharat B Aggarwal
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.
Carcinogenesis 2002;23(1):143-50.
2001: Asok Mukhopadhyay; Carlos E Bueso-Ramos; D Chatterjee; P Pantazis; Bharat B Aggarwal
Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines.
Oncogene 2001;20(52):7597-609.
2001: Paolo Fiumara; Virginia Snell; Yang Li; A Mukhopadhyay; Mamoun Younes; Ann M Gillenwater; Fernando Cabanillas; Bharat B Aggarwal; Anas Younes
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Blood 2001;98(9):2784-90.
2001: Sekhar Majumdar; Bharat B Aggarwal
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2911-20.
2001: Asok Mukhopadhyay; Jill Suttles; Robert D Stout; Bharat B Aggarwal
Genetic deletion of the tumor necrosis factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages.
The Journal of biological chemistry 2001;276(34):31906-12.
2001: P C Rath; Bharat B Aggarwal
Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(7):523-8.
2000: Sunil K Manna; Asok Mukhopadhyay; Bharat B Aggarwal
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5962-9.
2000: Bharat B Aggarwal
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB.
Annals of the rheumatic diseases 2000;59 Suppl 1():i6-16.
2000: Sunil K Manna; Asok Mukhopadhyay; Bharat B Aggarwal
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4927-34.
2000: Bharat B Aggarwal
Apoptosis and nuclear factor-kappa B: a tale of association and dissociation.
Biochemical pharmacology 2000;60(8):1033-9.
2000: S K Manna; Valsala Haridas; Bharat B Aggarwal
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(8):725-35.
2000: Sunil K Manna; Nand K Sah; Robert A Newman; A Cisneros; Bharat B Aggarwal
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
Cancer research 2000;60(14):3838-47.
2000: Sunil K Manna; Asok Mukhopadhyay; Bharat B Aggarwal
Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6509-19.
2000: gagan chainy; Sunil K Manna; Madan M Chaturvedi; Bharat B Aggarwal
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis.
Oncogene 2000;19(25):2943-50.
2000: Sunil K Manna; Bharat B Aggarwal
Vesnarinone suppresses TNF-induced activation of NF-kappa B, c-Jun kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5815-25.
2000: Sunil K Manna; Bharat B Aggarwal
Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5156-66.
2000: Sunil K Manna; Asok Mukhopadhyay; Bharat B Aggarwal
Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor.
The Journal of biological chemistry 2000;275(18):13307-14.
2000: Sunil K Manna; Nand K Sah; Bharat B Aggarwal
Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis.
The Journal of biological chemistry 2000;275(18):13297-306.
2000: Sunil K Manna; Bharat B Aggarwal
Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester.
FEBS letters 2000;473(1):113-8.
2000: Sunil K Manna; Bharat B Aggarwal
All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells.
Oncogene 2000;19(17):2110-9.
2000: Asok Mukhopadhyay; Sunil K Manna; Bharat B Aggarwal
Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha.
The Journal of biological chemistry 2000;275(12):8549-55.
1999: Sunil K Manna; Asok Mukhopadhyay; NT Van; Bharat B Aggarwal
Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6800-9.
1999: Chintala Shravan; Athanassios P Kyritsis; Pamarthi M Mohan; Sanjeeva Mohanam; Raymond Sawaya; Z Gokslan; W K Alfred Yung; PA Steck; Joon H Uhm; Bharat B Aggarwal; Jasti Sambasiva Rao
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Molecular carcinogenesis 1999;26(4):274-85.
1999: Anushree Kumar; Subhash Dhawan; Asok Mukhopadhyay; Bharat B Aggarwal
Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.
FEBS letters 1999;462(1-2):140-4.
1999: Valsala Haridas; A Shrivastava; J Su; GL Yu; Jian Ni; D Liu; S F Chen; Y Ni; Steve Ruben; Reiner Gentz; Bharat B Aggarwal
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.
Oncogene 1999;18(47):6496-504.
1999: Bryant G Darnay; Bharat B Aggarwal
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Annals of the rheumatic diseases 1999;58 Suppl 1():I2-I13.
1999: Zeev Estrov; S K Manna; David Harris; Quin Van; Elihu H Estey; Hagop M Kantarjian; Moshe Talpaz; Bharat B Aggarwal
Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells.
Blood 1999;94(8):2844-53.
1999: Sunil K Manna; M Tien Kuo; Bharat B Aggarwal
Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1.
Oncogene 1999;18(30):4371-82.
1999: Asok Mukhopadhyay; Jian Ni; Y Zhai; GL Yu; Bharat B Aggarwal
Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.
The Journal of biological chemistry 1999;274(23):15978-81.
1999: Sunil K Manna; Y P Gad; Asok Mukhopadhyay; Bharat B Aggarwal
Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.
Biochemical pharmacology 1999;57(7):763-74.
1999: Bryant G Darnay; Jian Ni; Paul Moore; Bharat B Aggarwal
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
The Journal of biological chemistry 1999;274(12):7724-31.
1999: Sunil K Manna; Bharat B Aggarwal
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2095-102.
1999: Sunil K Manna; Bharat B Aggarwal
Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1510-8.
1999: A Shrivastava; Bharat B Aggarwal
Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis.
Antioxidants & redox signaling 1999;1(2):181-91.
1999: Y Zhai; Jian Ni; G W Jiang; J Lu; L Xing; Clint Lincoln; KC Carter; Fouad Janat; D Kozak; S Xu; L Rojas; Bharat B Aggarwal; Steve Ruben; Lu-Yuan Li; Reiner Gentz; GL Yu
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):181-9.
1998: Sunil K Manna; Bharat B Aggarwal
Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NF-kappaB, AP-1, and c-Jun N-terminal kinase. Comparison with interleukin-13.
The Journal of biological chemistry 1998;273(50):33333-41.
1998: A Shrivastava; Sunil K Manna; R Ray; Bharat B Aggarwal
Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors.
Journal of virology 1998;72(12):9722-8.
1998: DK Giri; RT Mehta; RG Kansal; Bharat B Aggarwal
Mycobacterium avium-intracellulare complex activates nuclear transcription factor-kappaB in different cell types through reactive oxygen intermediates.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4834-41.
1998: Sunil K Manna; Bharat B Aggarwal
Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2873-80.
1998: Sunil K Manna; Bharat B Aggarwal
IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2863-72.
1998: Sujay Singh; Uma Raju; J Mendoza; P Pantazis; Bharat B Aggarwal
Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells.
Anti-cancer drugs 1998;9(8):703-14.
1998: Anushree Kumar; Subhash Dhawan; Bharat B Aggarwal
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.
Oncogene 1998;17(7):913-8.
1998: Bryant G Darnay; Valsala Haridas; Jian Ni; Paul Moore; Bharat B Aggarwal
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.
The Journal of biological chemistry 1998;273(32):20551-5.
1998: V Wright-Browne; A M Schnee; M A Jenkins; P F Thall; Bharat B Aggarwal; Moshe Talpaz; Zeev Estrov
Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence.
Leukemia & lymphoma 1998;30(5-6):583-9.
1998: Anushree Kumar; Sunil K Manna; Subhash Dhawan; Bharat B Aggarwal
HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):776-81.
1998: A Singh; J Ni; Bharat B Aggarwal
Death domain receptors and their role in cell demise.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(7):439-50.
1998: Byoung S Kwon; S Wang; N Udagawa; Valsala Haridas; Z H Lee; K K Kim; KO Oh; J Greene; Y Li; J Su; Reiner Gentz; Bharat B Aggarwal; Jian Ni
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(10):845-54.
1998: Valsala Haridas; Jian Ni; A Meager; J Su; GL Yu; Y Zhai; H Kyaw; KT Akama; J Hu; Linda Van Eldik; Bharat B Aggarwal
TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):1-6.
1998: DK Giri; Bharat B Aggarwal
Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates.
The Journal of biological chemistry 1998;273(22):14008-14.
1998: Chintala Shravan; Raymond Sawaya; Bharat B Aggarwal; Sadhan Majumder; DK Giri; Athanassios P Kyritsis; Ziya L Gokaslan; Jasti Sambasiva Rao
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
The Journal of biological chemistry 1998;273(22):13545-51.
1998: Sunil K Manna; H J Zhang; T Yan; L W Oberley; Bharat B Aggarwal
Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1.
The Journal of biological chemistry 1998;273(21):13245-54.
1998: Valsala Haridas; Bryant G Darnay; K Natarajan; R Heller; Bharat B Aggarwal
Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3152-62.
1998: K Natarajan; Sunil K Manna; Madan M Chaturvedi; Bharat B Aggarwal
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.
Archives of biochemistry and biophysics 1998;352(1):59-70.
1998: Anushree Kumar; Subhash Dhawan; Neil J Hardegen; Bharat B Aggarwal
Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.
Biochemical pharmacology 1998;55(6):775-83.
1998: R Mukherjee; S Singh; Madan M Chaturvedi; Bharat B Aggarwal
Evidence for a synergistic role of two types of human tumor necrosis factor receptors for the ligand-dependent activation of the nuclear transcription factor NF-kappaB.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(2):117-23.
1998: A Shrivastava; Bharat B Aggarwal
Cytokines as biological regulators of homeostasis.
Journal of biological regulators and homeostatic agents 1998;12(1-2):1-24.
1997: Madan M Chaturvedi; Addanki Kumar; Bryant G Darnay; gagan chainy; S Agarwal; Bharat B Aggarwal
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.
The Journal of biological chemistry 1997;272(48):30129-34.
1997: Bharat B Aggarwal; M Higuchi
Role of ceramide in tumour necrosis factor-mediated apoptosis and nuclear factor-kappa B activation.
Biochemical Society transactions 1997;25(4):1166-71.
1997: Bryant G Darnay; Bharat B Aggarwal
Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase.
FEBS letters 1997;410(2-3):361-7.
1997: Kapil Mehta; P Pantazis; Teresa McQueen; Bharat B Aggarwal
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.
Anti-cancer drugs 1997;8(5):470-81.
1997: Bryant G Darnay; Bharat B Aggarwal
Early events in TNF signaling: a story of associations and dissociations.
Journal of leukocyte biology 1997;61(5):559-66.
1997: Bryant G Darnay; S Singh; Bharat B Aggarwal
The p80 TNF receptor-associated kinase (p80TRAK) associates with residues 354-397 of the p80 cytoplasmic domain: similarity to casein kinase.
FEBS letters 1997;406(1-2):101-5.
1997: Kenneth L McClain; Zeev Estrov; U Raju; P K Kelley; Bharat B Aggarwal
Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes.
Methods (San Diego, Calif.) 1997;11(1):83-7.
1996: Saurabh Singh; Bryant G Darnay; Bharat B Aggarwal
Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.
The Journal of biological chemistry 1996;271(49):31049-54.
1996: Bharat B Aggarwal; L Schwarz; ME Hogan; RF Rando
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.
Cancer research 1996;56(22):5156-64.
1996: Saurabh Singh; K Natarajan; Bharat B Aggarwal
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4412-20.
1996: gagan chainy; Saurabh Singh; Uma Raju; Bharat B Aggarwal
Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2410-7.
1996: K Natarajan; Saurabh Singh; T R Burke; D Grunberger; Bharat B Aggarwal
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9090-5.
1996: M Higuchi; Saurabh Singh; J P Jaffrezou; Bharat B Aggarwal
Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):297-304.
1996: Bharat B Aggarwal; K Natarajan
Tumor necrosis factors: developments during the last decade.
European cytokine network 1996;7(2):93-124.
1996: K Totpal; Saurabh Singh; Ruth Lapushin; Bharat B Aggarwal
Qualitative and quantitative differences in the cellular responses mediated through Fas antigen and tumor necrosis factor receptor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(3):259-67.
1995: E Pocsik; Rudolf Mihalik; M Penzes; H Loetscher; H Gallati; Bharat B Aggarwal
Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors.
Journal of cellular biochemistry 1995;59(3):303-16.
1995: Saurabh Singh; Bharat B Aggarwal
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].
The Journal of biological chemistry 1995;270(42):24995-5000.
1995: Zeev Estrov; B Samal; Ruth Lapushin; P Kellokumpu-Lehtinen; A A Sahin; Razelle Kurzrock; Moshe Talpaz; Bharat B Aggarwal
Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(10):905-13.
1995: Bharat B Aggarwal; E Pocsik; K Totpal
Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor.
FEBS letters 1995;372(1):44-8.
1995: M Higuchi; Saurabh Singh; H Chan; Bharat B Aggarwal
Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation.
Blood 1995;86(6):2248-56.
1995: Bryant G Darnay; Saurabh Singh; Madan M Chaturvedi; Bharat B Aggarwal
The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signaling.
The Journal of biological chemistry 1995;270(25):14867-70.
1995: K Totpal; Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells.
Blood 1995;85(12):3547-55.
1995: Saurabh Singh; Bharat B Aggarwal
Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.
The Journal of biological chemistry 1995;270(18):10631-9.
1995: Bharat B Aggarwal; K Totpal; Ruth Lapushin; Madan M Chaturvedi; Olivia M Pereira-Smith; J R Smith
Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B.
Experimental cell research 1995;218(1):381-8.
1995: Bharat B Aggarwal; Saurabh Singh; Ruth Lapushin; K Totpal
Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor.
FEBS letters 1995;364(1):5-8.
1995: M Higuchi; S Singh; Bharat B Aggarwal
Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells.
Journal of immunological methods 1995;178(2):173-81.
1995: Bharat B Aggarwal; E Pocsik; K Totpal; Francis Ali-Osman
Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
FEBS letters 1995;357(1):1-6.
1995: A Sella; Bharat B Aggarwal; RG Kilbourn; C A Bui; A A Zukiwski; C J Logothetis
Phase I study of tumor necrosis factor plus actinomycin D in patients with androgen-independent prostate cancer.
Cancer biotherapy 1995;10(3):225-35.
1994: H Chan; Bharat B Aggarwal
Role of tumor necrosis factor receptors in the activation of nuclear factor kappa B in human histiocytic lymphoma U-937 cells.
The Journal of biological chemistry 1994;269(50):31424-9.
1994: Bharat B Aggarwal; E Pocsik; Francis Ali-Osman; K Totpal
Transfection of cells with transforming growth factor-alpha leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
FEBS letters 1994;354(1):12-6.
1994: L Zhang; Bharat B Aggarwal
Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3745-54.
1994: Shrikanth A G Reddy; Madan M Chaturvedi; Bryant G Darnay; H Chan; M Higuchi; Bharat B Aggarwal
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.
The Journal of biological chemistry 1994;269(41):25369-72.
1994: Madan M Chaturvedi; M Higuchi; Bharat B Aggarwal
Effect of tumor necrosis factors, interferons, interleukins, and growth factors on the activation of NF-kappa B: evidence for lack of correlation with cell proliferation.
Lymphokine and cytokine research 1994;13(5):309-13.
1994: K Totpal; Ruth Lapushin; T Kohno; Bryant G Darnay; Bharat B Aggarwal
TNF and its receptor antibody agonist differ in mediation of cellular responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2248-57.
1994: Bryant G Darnay; Shrikanth A G Reddy; Bharat B Aggarwal
Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.
The Journal of biological chemistry 1994;269(32):20299-304.
1994: Bryant G Darnay; Shrikanth A G Reddy; Bharat B Aggarwal
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.
The Journal of biological chemistry 1994;269(31):19687-90.
1994: Bharat B Aggarwal; K Totpal; Francis Ali-Osman; Raymond J A Budde; E Pocsik
pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
FEBS letters 1994;345(2-3):219-24.
1994: Madan M Chaturvedi; Ruth Lapushin; Bharat B Aggarwal
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
The Journal of biological chemistry 1994;269(20):14575-83.
1994: M Higuchi; Bharat B Aggarwal
Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4017-25.
1994: L Zhang; M Higuchi; K Totpal; Madan M Chaturvedi; Bharat B Aggarwal
Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response.
The Journal of biological chemistry 1994;269(14):10270-9.
1994: M Higuchi; Bharat B Aggarwal
TNF induces internalization of the p60 receptor and shedding of the p80 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3550-8.
1994: E Pocsik; Rudolf Mihalik; Francis Ali-Osman; Bharat B Aggarwal
Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response.
Journal of cellular biochemistry 1994;54(4):453-64.
1994: S Reddy; Bharat B Aggarwal
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
FEBS letters 1994;341(1):19-22.
1994: Bharat B Aggarwal; R Pandita
Both type I and type II interferons down-regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2. Role of protein kinase C.
FEBS letters 1994;337(1):99-102.
1994: Ruth Lapushin; K Totpal; M Higuchi; Bharat B Aggarwal
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.
Journal of clinical immunology 1994;14(1):39-49.
1993: M Higuchi; Bharat B Aggarwal
P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation.
FEBS letters 1993;331(3):252-5.
1993: Bharat B Aggarwal; K Graff; B Samal; M Higuchi; Warren S-L Liao
Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937.
Lymphokine and cytokine research 1993;12(3):149-58.
1993: M Higuchi; Bharat B Aggarwal
Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.
The Journal of biological chemistry 1993;268(8):5624-31.
1993: Zeev Estrov; Razelle Kurzrock; E Pocsik; Sen Pathak; H M Kantarjian; Theodore F Zipf; D Harris; Moshe Talpaz; Bharat B Aggarwal
Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines.
The Journal of experimental medicine 1993;177(3):763-74.
1993: Bharat B Aggarwal; P K Gadhia; Vicki L Hopwood; B J Dave; S Risin; Laurie B Owen-Schaub; R Pandita; Sen Pathak
Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B lymphoblastoid cells derived from cancer patients.
Lymphokine and cytokine research 1993;12(1):9-19.
1992: E Pocsik; M Higuchi; Bharat B Aggarwal
Down-modulation of cell surface expression of p80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene.
Lymphokine and cytokine research 1992;11(6):317-25.
1992: R Pandita; E Pocsik; Bharat B Aggarwal
Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors.
FEBS letters 1992;312(1):87-90.
1992: M Higuchi; Bharat B Aggarwal
Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.
The Journal of biological chemistry 1992;267(29):20892-9.
1992: K Totpal; S Agarwal; Bharat B Aggarwal
Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells.
Cancer research 1992;52(9):2557-62.
1992: A Fernandez; P W Chen; Bharat B Aggarwal; Honnavara N Ananthaswamy
Resistance of Ha-ras oncogene-induced progressor tumor variants to tumor necrosis factor and interferon-gamma.
Lymphokine and cytokine research 1992;11(2):79-85.
1992: Bharat B Aggarwal; E Pocsik
Cytokines: from clone to clinic.
Archives of biochemistry and biophysics 1992;292(2):335-59.
1992: M Higuchi; Bharat B Aggarwal
Inhibition of ligand binding and antiproliferative effects of tumor necrosis factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors.
Biochemical and biophysical research communications 1992;182(2):638-43.
1992: Bharat B Aggarwal
Comparative analysis of the structure and function of TNF-alpha and TNF-beta.
Immunology series 1992;56():61-78.
1992: Constantin G Ioannides; Bryan Fisk; B Tomasovic; R Pandita; Bharat B Aggarwal; Ralph S Freedman
Induction of interleukin-2 receptor by tumor necrosis factor alpha on cultured ovarian tumor-associated lymphocytes.
Cancer immunology, immunotherapy : CII 1992;35(2):83-91.
1991: K Totpal; Ruth Lapushin; Honnavara N Ananthaswamy; Bharat B Aggarwal
In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo.
Lymphokine and cytokine research 1991;10(5):359-67.
1991: K Totpal; Bharat B Aggarwal
Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines.
Cancer research 1991;51(16):4266-70.
1990: K Jagannadha Sastry; H R Reddy; R Pandita; K Totpal; Bharat B Aggarwal
HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line.
The Journal of biological chemistry 1990;265(33):20091-3.
1990: Bharat B Aggarwal
Lymphotoxin and tumor necrosis factor: qualitative and quantitative differences in their receptors and signal transduction in various cell types.
Progress in clinical and biological research 1990;349():375-84.