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CA Omer

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Physiology

Protein Prenylation

Concepts & Ideas

Living Beings

Anatomy

Cell Line, Transformed

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Publications

TOP 3
Robert B Lobell; CA Omer; Marc T Abrams; HG Bhimnathwala; MJ Brucker; Carolyn A Buser; Joseph P Davide; S Jane deSolms; Christopher Dinsmore; Michelle Ellis-Hutchings; AM Kral; Dongming Liu; William C Lumma; S V Machotka; Elaine Rands; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff; David C Heimbrook; Nancy E Kohl
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Ian M Bell; Steven N Gallicchio; M Abrams; Douglas C Beshore; Carolyn A Buser; J Christopher Culberson; Joseph P Davide; Michelle Ellis-Hutchings; Christine Fernandes; Jackson B Gibbs; Samuel L Graham; George D Hartman; David C Heimbrook; Carl F Homnick; Joel R Huff; Kelem Kassahun; Kenneth S Koblan; Nancy E Kohl; Robert B Lobell; Joseph J Lynch; P A Miller; CA Omer; A David Rodrigues; Eileen S Walsh; Theresa M Williams
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
CA Omer; Z Chen; Ronald E Diehl; MW Conner; H Y Chen; Myrna E Trumbauer; Shobhna Gopal-Truter; G Seeburger; HG Bhimnathwala; Marc T Abrams; Joseph P Davide; M S Ellis; Jackson B Gibbs; IB Greenberg; Kenneth S Koblan; AM Kral; Dongming Liu; Robert B Lobell; PJ Miller; Scott D Mosser; TJ O'Neill; Elaine Rands; Michael D Schaber; ET Senderak; Allen Oliff; Nancy E Kohl
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

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All Publications

2001: Robert B Lobell; CA Omer; Marc T Abrams; HG Bhimnathwala; MJ Brucker; Carolyn A Buser; Joseph P Davide; S Jane deSolms; Christopher Dinsmore; Michelle Ellis-Hutchings; AM Kral; Dongming Liu; William C Lumma; S V Machotka; Elaine Rands; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff; David C Heimbrook; Nancy E Kohl
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Cancer research 2001;61(24):8758-68.
2001: Ian M Bell; Steven N Gallicchio; M Abrams; Douglas C Beshore; Carolyn A Buser; J Christopher Culberson; Joseph P Davide; Michelle Ellis-Hutchings; Christine Fernandes; Jackson B Gibbs; Samuel L Graham; George D Hartman; David C Heimbrook; Carl F Homnick; Joel R Huff; Kelem Kassahun; Kenneth S Koblan; Nancy E Kohl; Robert B Lobell; Joseph J Lynch; P A Miller; CA Omer; A David Rodrigues; Eileen S Walsh; Theresa M Williams
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
Journal of medicinal chemistry 2001;44(18):2933-49.
2000: CA Omer; Z Chen; Ronald E Diehl; MW Conner; H Y Chen; Myrna E Trumbauer; Shobhna Gopal-Truter; G Seeburger; HG Bhimnathwala; Marc T Abrams; Joseph P Davide; M S Ellis; Jackson B Gibbs; IB Greenberg; Kenneth S Koblan; AM Kral; Dongming Liu; Robert B Lobell; PJ Miller; Scott D Mosser; TJ O'Neill; Elaine Rands; Michael D Schaber; ET Senderak; Allen Oliff; Nancy E Kohl
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Cancer research 2000;60(10):2680-8.
1999: CA Omer; PJ Miller; Ronald E Diehl; AM Kral
Identification of Tcf4 residues involved in high-affinity beta-catenin binding.
Biochemical and biophysical research communications 1999;256(3):584-90.
1998: Nancy E Kohl; Kenneth S Koblan; CA Omer; Allen Oliff; Jackson B Gibbs
Biochemical and biological analyses of farnesyl-protein transferase inhibitors.
Methods in molecular biology (Clifton, N.J.) 1998;84():283-91.
1998: RE Barrington; Mark A Subler; Elaine Rands; CA Omer; PJ Miller; JE Hundley; SK Koester; Dean A Troyer; David J Bearss; MW Conner; Jackson B Gibbs; Kelly Hamilton; Kenneth S Koblan; Scott D Mosser; TJ O'Neill; Michael D Schaber; ET Senderak; Jolene J Windle; Allen Oliff; Nancy E Kohl
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
Molecular and cellular biology 1998;18(1):85-92.
1997: CA Omer; Nancy E Kohl
CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents.
Trends in pharmacological sciences 1997;18(11):437-44.
1997: AM Kral; Ronald E Diehl; S Jane deSolms; Theresa M Williams; Nancy E Kohl; CA Omer
Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase.
The Journal of biological chemistry 1997;272(43):27319-23.
1997: Jackson B Gibbs; Samuel L Graham; George D Hartman; Kenneth S Koblan; Nancy E Kohl; CA Omer; Allen Oliff
Farnesyltransferase inhibitors versus Ras inhibitors.
Current opinion in chemical biology 1997;1(2):197-203.
1997: CA Omer; Neville J Anthony; Carolyn Buser-Doepner; A L Burkhardt; S Jane deSolms; Christopher Dinsmore; Jackson B Gibbs; George D Hartman; Kenneth S Koblan; Robert B Lobell; Allen Oliff; Theresa M Williams; Nancy E Kohl
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
BioFactors (Oxford, England) 1997;6(3):359-66.
1996: A Wallace; Kenneth S Koblan; K Hamilton; D J Marquis-Omer; P J Miller; Scott D Mosser; CA Omer; Michael D Schaber; Riccardo Cortese; Allen Oliff; Jackson B Gibbs; Antonello Pessi
Selection of potent inhibitors of farnesyl-protein transferase from a synthetic tetrapeptide combinatorial library.
The Journal of biological chemistry 1996;271(49):31306-11.
1996: Kenneth S Koblan; Nancy E Kohl; CA Omer; Neville J Anthony; M W Conner; S Jane deSolms; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff; Jackson B Gibbs
Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
Biochemical Society transactions 1996;24(3):688-92.
1996: Theresa M Williams; T M Ciccarone; Suzanne C MacTough; R L Bock; M W Conner; J P Davide; K Hamilton; Kenneth S Koblan; Nancy E Kohl; AM Kral; Scott D Mosser; CA Omer; DL Pompliano; Elaine Rands; Michael D Schaber; D Shah; F R Wilson; Jackson B Gibbs; Samuel L Graham; George D Hartman; Allen Oliff; R L Smith
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
Journal of medicinal chemistry 1996;39(7):1345-8.
1996: Jackson B Gibbs; Nancy E Kohl; Kenneth S Koblan; CA Omer; Laura Sepp-Lorenzino; Neal Rosen; Neville J Anthony; M W Conner; S Jane deSolms; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff
Farnesyltransferase inhibitors and anti-Ras therapy.
Breast cancer research and treatment 1996;38(1):75-83.
1995: Nancy E Kohl; CA Omer; M W Conner; Neville J Anthony; J P Davide; S Jane deSolms; E A Giuliani; R P Gomez; Samuel L Graham; K Hamilton
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.
Nature medicine 1995;1(8):792-7.
1995: Kenneth S Koblan; J Christopher Culberson; S Jane deSolms; E A Giuliani; Scott D Mosser; CA Omer; Steven M Pitzenberger; Michael J Bogusky
NMR studies of novel inhibitors bound to farnesyl-protein transferase.
Protein science : a publication of the Protein Society 1995;4(4):681-8.
1995: CA Omer; Ronald E Diehl; AM Kral
Bacterial expression and purification of human protein prenyltransferases using epitope-tagged, translationally coupled systems.
Methods in enzymology 1995;250():3-12.
1994: F L Zhang; Ronald E Diehl; Nancy E Kohl; Jackson B Gibbs; Bruno GIROS; Patrick J Casey; CA Omer
cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.
The Journal of biological chemistry 1994;269(5):3175-80.
1994: CA Omer; Jackson B Gibbs
Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry.
Molecular microbiology 1994;11(2):219-25.
1993: George C Prendergast; J P Davide; AM Kral; Ronald E Diehl; Jackson B Gibbs; CA Omer; Nancy E Kohl
Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(9):707-13.
1993: DL Pompliano; Michael D Schaber; Scott D Mosser; CA Omer; Jules A Shafer; Jackson B Gibbs
Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.
Biochemistry 1993;32(32):8341-7.
1993: CA Omer; AM Kral; Ronald E Diehl; George C Prendergast; S Powers; C M Allen; Jackson B Gibbs; Nancy E Kohl
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.
Biochemistry 1993;32(19):5167-76.