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Satoshi Omura

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Physiology

Fermentation

Chemicals & Drugs

Living Beings

Genes & Molecular Sequences

Molecular Structure

Phenomena

Procedures

Microbial Sensitivity Tests

Concepts & Ideas

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Co-Publications
Name
129
Tomoda, Hiroshi
65
Shiomi, Kazuro
64
Masuma, Rokuro
61
Sunazuka, Toshiaki
36
Otoguro, Kazuhiko
36
Tabata, Noriko
30
Komiyama, Kanki
25
Tanaka, Haruo
23
Takahashi, Y
20
Takahashi, Yoko
20
Ui, Hideaki
20
Inokoshi, Junji
20
Hayashi, Masahiko
19
Harigaya, Yoshihiro
17
Yamaguchi, Yuichi

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Publications

TOP 3
Mogi Tatsushi; Murase Yoshiro; Mori Mihoko; Shiomi Kazuro; Omura Satoshi; Paranagama Madhavi P; Kita Kiyoshi
Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis.
Gouda Hiroaki; Terashima Shinichi; Iguchi Kanami; Sugawara Akihiro; Saito Yoshifumi; Yamamoto Tsuyoshi; Hirose Tomoyasu; Shiomi Kazuro; Sunazuka Toshiaki; Omura Satoshi; Hirono Shuichi
Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.
Mogi Tatsushi; Kawakami Takuro; Arai Hiroyuki; Igarashi Yasuo; Matsushita Kazunobu; Mori Mihoko; Shiomi Kazuro; Omura Satoshi; Harada Shigeharu; Kita Kiyoshi
Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.

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All Publications

2009: Mogi Tatsushi; Murase Yoshiro; Mori Mihoko; Shiomi Kazuro; Omura Satoshi; Paranagama Madhavi P; Kita Kiyoshi
Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis.
Journal of biochemistry 2009;146(4):491-9.
2009: Gouda Hiroaki; Terashima Shinichi; Iguchi Kanami; Sugawara Akihiro; Saito Yoshifumi; Yamamoto Tsuyoshi; Hirose Tomoyasu; Shiomi Kazuro; Sunazuka Toshiaki; Omura Satoshi; Hirono Shuichi
Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.
Bioorganic & medicinal chemistry 2009;17(17):6270-8.
2009: Mogi Tatsushi; Kawakami Takuro; Arai Hiroyuki; Igarashi Yasuo; Matsushita Kazunobu; Mori Mihoko; Shiomi Kazuro; Omura Satoshi; Harada Shigeharu; Kita Kiyoshi
Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.
Journal of biochemistry 2009;146(3):383-7.
2009: Yamazaki Hiroyuki; Nonaka Kenichi; Masuma Rokuro; Omura Satoshi; Tomoda Hiroshi
Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 2009;62(8):431-4.
2009: Yamazaki Hiroyuki; Omura Satoshi; Tomoda Hiroshi
Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 II. Structure elucidation.
The Journal of antibiotics 2009;62(8):435-7.
2009: Mogi Tatsushi; Ano Yoshitaka; Nakatsuka Tomoko; Toyama Hirohide; Muroi Atsushi; Miyoshi Hideto; Migita Catharina T; Ui Hideaki; Shiomi Kazuro; Omura Satoshi; Kita Kiyoshi; Matsushita Kazunobu
Biochemical and spectroscopic properties of cyanide-insensitive quinol oxidase from Gluconobacter oxydans.
Journal of biochemistry 2009;146(2):263-71.
2009: Matsumoto Atsuko; Kasai Hiroki; Matsuo Yoshihide; Omura Satoshi; Shizuri Yoshikazu; Takahashi Yoko
Ilumatobacter fluminis gen. nov., sp. nov., a novel actinobacterium isolated from the sediment of an estuary.
The Journal of general and applied microbiology 2009;55(3):201-5.
2009: Takishima Shunsuke; Ishiyama Aki; Iwatsuki Masato; Otoguro Kazuhiko; Yamada Haruki; Omura Satoshi; Kobayashi Hirotsugu; van Soest Rob W M; Matsunaga Shigeki
Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.
Organic letters 2009;11(12):2655-8.
2009: Ishiyama Aki; Otoguro Kazuhiko; Iwatsuki Masato; Namatame Miyuki; Nishihara Aki; Nonaka Kenichi; Kinoshita Yuta; Takahashi Yoko; Masuma Rokuro; Shiomi Kazuro; Yamada Haruki; Omura Satoshi
In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.
The Journal of antibiotics 2009;62(6):303-8.
2009: Ohtawa Masaki; Ogihara Satoru; Sugiyama Kouhei; Shiomi Kazuro; Harigaya Yoshihiro; Nagamitsu Tohru; Omura Satoshi
Enantioselective total synthesis of atpenin A5.
The Journal of antibiotics 2009;62(6):289-94.
2009: Hirose Tomoyasu; Sunazuka Toshiaki; Sugawara Akihiro; Endo Ayako; Iguchi Kanami; Yamamoto Tsuyoshi; Ui Hideaki; Shiomi Kazuro; Watanabe Takeshi; Sharpless K Barry; Omura Satoshi
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry.
The Journal of antibiotics 2009;62(5):277-82.
2009: Ohshiro Taichi; Matsuda Daisuke; Nagai Kenichiro; Doi Takayuki; Sunazuka Toshiaki; Takahashi Takashi; Rudel Lawrence Lee; Omura Satoshi; Tomoda Hiroshi
The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase.
Chemical & pharmaceutical bulletin 2009;57(4):377-81.
2009: Yamazaki Hiroyuki; Omura Satoshi; Tomoda Hiroshi
Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation.
The Journal of antibiotics 2009;62(4):207-11.
2009: Yamazaki Hiroyuki; Kobayashi Kakeru; Matsuda Daisuke; Nonaka Kenichi; Masuma Rokuro; Omura Satoshi; Tomoda Hiroshi
Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 2009;62(4):195-200.
2009: Sunazuka Toshiaki; Sugawara Akihiro; Iguchi Kanami; Hirose Tomoyasu; Nagai Kenichiro; Noguchi Yoshihiko; Saito Yoshifumi; Yamamoto Tsuyoshi; Ui Hideaki; Gouda Hiroaki; Shiomi Kazuro; Watanabe Takeshi; Omura Satoshi
Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.
Bioorganic & medicinal chemistry 2009;17(7):2751-8.
2009: Morales Jorge; Mogi Tatsushi; Mineki Shigeru; Takashima Eizo; Mineki Reiko; Hirawake Hiroko; Sakamoto Kimitoshi; Omura Satoshi; Kita Kiyoshi
Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit.
The Journal of biological chemistry 2009;284(11):7255-63.
2009: Mogi Tatsushi; Ui Hideaki; Shiomi Kazuro; Omura Satoshi; Miyoshi Hideto; Kita Kiyoshi
Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases.
Biochimica et biophysica acta 2009;1787(2):129-33.
2009: Mogi Tatsushi; Matsushita Kazunobu; Murase Yoshiro; Kawahara Kenji; Miyoshi Hideto; Ui Hideaki; Shiomi Kazuro; Omura Satoshi; Kita Kiyoshi
Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II).
FEMS microbiology letters 2009;291(2):157-61.
2009: Shimamura Hiroyuki; Gouda Hiroaki; Nagai Kenichiro; Hirose Tomoyasu; Ichioka Maki; Furuya Yujiro; Kobayashi Yutaka; Hirono Shuichi; Sunazuka Toshiaki; Omura Satoshi
Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE.
Angewandte Chemie (International ed. in English) 2009;48(5):914-7.
2008: Ara Ismet; Matsumoto Atsuko; Abdul Bakir Mohammad; Kudo Takuji; Omura Satoshi; Takahashi Yoko
Actinomadura maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere soil of Maheshkhali, Bangladesh.
The Journal of general and applied microbiology 2008;54(6):335-42.
2008: Ishiyama Aki; Otoguro Kazuhiko; Namatame Miyuki; Nishihara Aki; Furusawa Toshiaki; Masuma Rokuro; Shiomi Kazuro; Takahashi Yoko; Ichimura Michio; Yamada Haruki; Omura Satoshi
In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin.
The Journal of antibiotics 2008;61(10):627-32.
2008: Kageyama Akiko; Haga Tomomi; Kasai Hiroaki; Shizuri Yoshikazu; Omura Satoshi; Takahashi Yoko
Marihabitans asiaticum gen. nov., sp. nov., a meso-diaminopimelic acid-containing member of the family Intrasporangiaceae.
International journal of systematic and evolutionary microbiology 2008;58(Pt 10):2429-32.
2008: Fukuda Takashi; Hasegawa Yoko; Sakabe Yasunari; Tomoda Hiroshi; Omura Satoshi
Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.
The Journal of antibiotics 2008;61(9):550-5.
2008: Ohshiro Taichi; Ohte Satoshi; Matsuda Daisuke; Ohtawa Masaki; Nagamitsu Tohru; Sunazuka Toshiaki; Harigaya Yoshihiro; Rudel Lawrence L; Omura Satoshi; Tomoda Hiroshi
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.
The Journal of antibiotics 2008;61(8):503-8.
2008: Nagai Kenichiro; Doi Takayuki; Ohshiro Taichi; Sunazuka Toshiaki; Tomoda Hiroshi; Takahashi Takashi; Omura Satoshi
Synthesis and biological evaluation of a focused library of beauveriolides.
Bioorganic & medicinal chemistry letters 2008;18(15):4397-400.
2008: Yamazaki Hiroyuki; Koyama Nobuhiro; Omura Satoshi; Tomoda Hiroshi
Structure-activity relationships of stemphones, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus.
The Journal of antibiotics 2008;61(7):426-41.
2008: Ara Ismet; Matsumoto Atsuko; Bakir Mohammad Abdul; Kudo Takuji; Omura Satoshi; Takahashi Yoko
Actinomadura bangladeshensis sp. nov. and Actinomadura chokoriensis sp. nov.
International journal of systematic and evolutionary microbiology 2008;58(Pt 7):1653-9.
2008: Ara Ismet; Matsumoto Atsuko; Bakir Mohammad Abdul; Kudo Takuji; Omura Satoshi; Takahashi Yoko
Pseudosporangium ferrugineum gen. nov., sp. nov., a new member of the family Micromonosporaceae.
International journal of systematic and evolutionary microbiology 2008;58(Pt 7):1644-52.
2008: Kageyama Akiko; Matsumoto Atsuko; Omura Satoshi; Takahashi Yoko
Humibacillus xanthopallidus gen. nov., sp. nov.
International journal of systematic and evolutionary microbiology 2008;58(Pt 7):1547-51.
2008: Mogi Tatsushi; Ui Hideaki; Shiomi Kazuro; Omura Satoshi; Kita Kiyoshi
Gramicidin S identified as a potent inhibitor for cytochrome bd-type quinol oxidase.
FEBS letters 2008;582(15):2299-302.
2008: Matsuda Daisuke; Namatame Ichiji; Ohshiro Taichi; Ishibashi Shun; Omura Satoshi; Tomoda Hiroshi
Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor.
The Journal of antibiotics 2008;61(5):318-21.
2008: Kojima Yasuhiro; Sunazuka Toshiaki; Nagai Kenichiro; Julfakyan Khachatur; Fukuda Takashi; Tomoda Hiroshi; Omura Satoshi
Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.
The Journal of antibiotics 2008;61(5):297-302.
2008: Komatsu Mamoru; Tsuda Muneya; Omura Satoshi; Oikawa Hideaki; Ikeda Haruo
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(21):7422-7.
2008: Matsumoto Atsuko; Yamada Mayuko; Omura Satoshi; Takahashi Yoko
Microterricola viridarii gen. nov., sp. nov., a new member of the family Microbacteriaceae.
International journal of systematic and evolutionary microbiology 2008;58(Pt 4):1019-23.
2008: Gouda Hiroaki; Yanai Yuichi; Sugawara Akihiro; Sunazuka Toshiaki; Omura Satoshi; Hirono Shuichi
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.
Bioorganic & medicinal chemistry 2008;16(7):3565-79.
2008: Sunazuka Toshiaki; Shudo Hiroko; Nagai Kenichiro; Yoshida Kiminari; Yamaguchi Yukie; Hanaki Hideaki; Omura Satoshi
4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria.
The Journal of antibiotics 2008;61(3):175-84.
2008: Fukumoto Atsushi; Kim Yong-Pil; Hanaki Hideaki; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. II. Biological activities.
The Journal of antibiotics 2008;61(1):7-10.
2008: Fukumoto Atsushi; Kim Yong-Pil; Matsumoto Atsuko; Takahashi Yoko; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structural elucidation.
The Journal of antibiotics 2008;61(1):1-6.
2008: Kageyama Akiko; Morisaki Kurimi; Omura Satoshi; Takahashi Yoko
Arthrobacter oryzae sp. nov. and Arthrobacter humicola sp. nov.
International journal of systematic and evolutionary microbiology 2008;58(Pt 1):53-6.
2007: Matsumoto Atsuko; Takahashi Yoko; Fukumoto Megumi; Omura Satoshi
Actinocatenispora sera sp. nov., isolated by long-term culturing.
International journal of systematic and evolutionary microbiology 2007;57(Pt 11):2651-4.
2007: Sugawara Akihiro; Sunazuka Toshiaki; Hirose Tomoyasu; Nagai Kenichiro; Yamaguchi Yukie; Hanaki Hideaki; Sharpless K Barry; Omura Satoshi
Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity.
Bioorganic & medicinal chemistry letters 2007;17(22):6340-4.
2007: Kageyama Akiko; Takahashi Yoko; Matsuo Yoshihide; Kasai Hiroaki; Shizuri Yoshikazu; Omura Satoshi
Microbacterium sediminicola sp. nov. and Microbacterium marinilacus sp. nov., isolated from marine environments.
International journal of systematic and evolutionary microbiology 2007;57(Pt 10):2355-9.
2007: Hasegawa Yoko; Fukuda Takashi; Hagimori Keiichi; Tomoda Hiroshi; Omura Satoshi
Tensyuic acids, new antibiotics produced by Aspergillus niger FKI-2342.
Chemical & pharmaceutical bulletin 2007;55(9):1338-41.
2007: Kageyama Akiko; Takahashi Yoko; Omura Satoshi
Humihabitans oryzae gen. nov., sp. nov.
International journal of systematic and evolutionary microbiology 2007;57(Pt 9):2163-6.
2007: Hagimori Keiichi; Fukuda Takashi; Hasegawa Yoko; Omura Satoshi; Tomoda Hiroshi
Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells.
Biological & pharmaceutical bulletin 2007;30(8):1379-83.
2007: Ara Ismet; Kudo Takuji; Matsumoto Atsuko; Takahashi Yoko; Omura Satoshi
Nonomuraea bangladeshensis sp. nov. and Nonomuraea coxensis sp. nov.
International journal of systematic and evolutionary microbiology 2007;57(Pt 7):1504-9.
2007: Kageyama Akiko; Takahashi Yoko; Yasumoto-Hirose Mina; Kasai Hiroaki; Shizuri Yoshikazu; Omura Satoshi
Janibacter corallicola sp. nov., isolated from coral in Palau.
The Journal of general and applied microbiology 2007;53(3):185-9.
2007: Ara Ismet; Kudo Takuji; Matsumoto Atsuko; Takahashi Yoko; Omura Satoshi
Nonomuraea maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere mud.
The Journal of general and applied microbiology 2007;53(3):159-66.
2007: Kita Kiyoshi; Shiomi Kazuro; Omura Satoshi
Advances in drug discovery and biochemical studies.
Trends in parasitology 2007;23(5):223-9.
2007: Nagamitsu Tohru; Takano Daisuke; Marumoto Kaori; Fukuda Takeo; Furuya Kentaro; Otoguro Kazuhiko; Takeda Kazuyoshi; Kuwajima Isao; Harigaya Yoshihiro; Omura Satoshi
Total synthesis of borrelidin.
The Journal of organic chemistry 2007;72(8):2744-56.
2007: Ui Hideaki; Ishiyama Aki; Sekiguchi Hitomi; Namatame Miyuki; Nishihara Aki; Takahashi Yoko; Shiomi Kazuro; Otoguro Kazuhiko; Omura Satoshi
Selective and potent in vitro antimalarial activities found in four microbial metabolites.
The Journal of antibiotics 2007;60(3):220-2.
2007: Kageyama Akiko; Takahashi Yoko; Omura Satoshi
Microbacterium terricolae sp. nov., isolated from soil in Japan.
The Journal of general and applied microbiology 2007;53(1):1-5.
2007: Ohshiro Taichi; Rudel Lawrence L; Omura Satoshi; Tomoda Hiroshi
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.
The Journal of antibiotics 2007;60(1):43-51.
2006: Ui Hideaki; Shiomi Kazuro; Suzuki Hideaki; Hatano Hiroko; Morimoto Hiromi; Yamaguchi Yuichi; Masuma Rokuro; Sunazuka Toshiaki; Shimamura Hiroyuki; Sakamoto Kimitoshi; Kita Kiyoshi; Miyoshi Hideto; Tomoda Hiroshi; Omura Satoshi
Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083.
The Journal of antibiotics 2006;59(12):785-90.
2006: Fukuda Takashi; Sakabe Yasunari; Tomoda Hiroshi; Omura Satoshi
Fungal citridone D having a novel phenylfuropyridine skeleton.
Chemical & pharmaceutical bulletin 2006;54(12):1659-61.
2006: Monma Souichi; Sunazuka Toshiaki; Nagai Kenichiro; Arai Takahiro; Shiomi Kazuro; Matsui Ryosuke; Omura Satoshi
Verticilide: elucidation of absolute configuration and total synthesis.
Organic letters 2006;8(24):5601-4.
2006: Tsuchiya Satoshi; Sunazuka Toshiaki; Hirose Tomoyasu; Mori Ryuma; Tanaka Toshiaki; Iwatsuki Masato; Omura Satoshi
Asymmetric total synthesis of (+)-K01-0509 B: determination of absolute configuration.
Organic letters 2006;8(24):5577-80.
2006: Uchida Ryuji; Imasato Rie; Tomoda Hiroshi; Omura Satoshi
Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. II. Structural elucidation.
The Journal of antibiotics 2006;59(10):652-8.
2006: Uchida Ryuji; Imasato Rie; Yamaguchi Yuichi; Masuma Rokuro; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity.
The Journal of antibiotics 2006;59(10):646-51.
2006: Ui Hideaki; Shiomi Kazuro; Suzuki Hideaki; Hatano Hiroko; Morimoto Hiromi; Yamaguchi Yuichi; Masuma Rokuro; Sakamoto Kimitoshi; Kita Kiyoshi; Miyoshi Hideto; Tomoda Hiroshi; Tanaka Haruo; Omura Satoshi
Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550.
The Journal of antibiotics 2006;59(9):591-6.
2006: Ohshiro Taichi; Namatame Ichiji; Nagai Kenichiro; Sekiguchi Takafumi; Doi Takayuki; Takahashi Takashi; Akasaka Kazuaki; Rudel Lawrence L; Tomoda Hiroshi; Omura Satoshi
Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers.
The Journal of organic chemistry 2006;71(20):7643-9.
2006: Kageyama Akiko; Takahashi Yoko; Omura Satoshi
Microbacterium deminutum sp. nov., Microbacterium pumilum sp. nov. and Microbacterium aoyamense sp. nov.
International journal of systematic and evolutionary microbiology 2006;56(Pt 9):2113-7.
2006: Fukuda Takashi; Hasegawa Yoko; Hagimori Keiichi; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Omura Satoshi
Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342.
The Journal of antibiotics 2006;59(8):480-5.
2006: Ichino Chikara; Kiyohara Hiroaki; Soonthornchareonnon Noppamas; Chuakul Wongsatit; Ishiyama Aki; Sekiguchi Hitomi; Namatame Miyuki; Otoguro Kazuhiko; Omura Satoshi; Yamada Haruki
Antimalarial activity of biflavonoids from Ochna integerrima.
Planta medica 2006;72(7):611-4.
2006: Uchida Ryuji; Tomoda Hiroshi; Omura Satoshi
Biosynthesis of sespendole.
The Journal of antibiotics 2006;59(5):298-302.
2006: Yamamoto Daisuke; Sunazuka Toshiaki; Hirose Tomoyasu; Kojima Naoto; Kaji Eisuke; Omura Satoshi
Design, synthesis, and biological activities of madindoline analogues.
Bioorganic & medicinal chemistry letters 2006;16(10):2807-11.
2006: Gouda Hiroaki; Sunazuka Toshiaki; Yoshida Kiminari; Sugawara Akihiro; Sakoh Yusuke; Omura Satoshi; Hirono Shuichi
Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation.
Bioorganic & medicinal chemistry letters 2006;16(9):2496-9.
2006: Ichino C; Soonthornchareonnon N; Chuakul W; Kiyohara H; Ishiyama A; Sekiguchi H; Namatame M; Otoguro K; Omura S; Yamada H
Screening of Thai medicinal plant extracts and their active constituents for in vitro antimalarial activity.
Phytotherapy research : PTR 2006;20(4):307-9.
2006: Uchida Ryuji; Kim Yong-Pil; Namatame Ichiji; Tomoda Hiroshi; Omura Satoshi
Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25.
The Journal of antibiotics 2006;59(2):93-7.
2006: Takahashi Yoko; Matsumoto Atsuko; Morisaki Kurimi; Omura Satoshi
Patulibacter minatonensis gen. nov., sp. nov., a novel actinobacterium isolated using an agar medium supplemented with superoxide dismutase, and proposal of Patulibacteraceae fam. nov.
International journal of systematic and evolutionary microbiology 2006;56(Pt 2):401-6.
2005: Uchida Ryuji; Imasato Rie; Yamaguchi Yuichi; Masuma Rokuro; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
New insecticidal antibiotics, hydroxyfungerins A and B, produced by Metarhizium sp. FKI-1079.
The Journal of antibiotics 2005;58(12):804-9.
2005: Sunazuka Toshiaki; Omura Satoshi
Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites.
Chemical reviews 2005;105(12):4559-80.
2005: Gouda Hiroaki; Sunazuka Toshiaki; Ui Hideaki; Handa Masaki; Sakoh Yusuke; Iwai Yuzuru; Hirono Shuichi; Omura Satoshi
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18286-91.
2005: Uchida Ryuji; Imasato Rie; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
Yaequinolones J1 and J2, novel insecticidal antibiotics from Penicillium sp. FKI-2140.
Organic letters 2005;7(25):5701-4.
2005: Koyama Nobuhiro; Nagahiro Tomoko; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Omura Satoshi
Stemphones, novel potentiators of imipenem activity against methicillin-resistant staphylococcus aureus, produced by Aspergillus sp. FKI-2136.
The Journal of antibiotics 2005;58(11):695-703.
2005: Kageyama Akiko; Takahashi Yoko; Seki Tamae; Tomoda Hiroshi; Omura Satoshi
Oryzihumus leptocrescens gen. nov., sp. nov.
International journal of systematic and evolutionary microbiology 2005;55(Pt 6):2555-9.
2005: Shibuya Masaaki; Snider Barry B; Sakano Yuichi; Tomoda Hiroshi; Omura Satoshi; Ebizuka Yutaka
Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929.
The Journal of antibiotics 2005;58(9):599-601.
2005: Ui Hideaki; Asanuma Satoshi; Chiba Harumi; Takahashi Atsushi; Yamaguchi Yuichi; Masuma Rokuro; Omura Satoshi; Tanaka Haruo
Mycophenolic acid inhibits syncytium formation accompanied by reduction of gp120 expression.
The Journal of antibiotics 2005;58(8):514-8.
2005: Matsui Hidenori; Eguchi Masahiro; Ohsumi Katsufumi; Nakamura Akio; Isshiki Yasunori; Sekiya Kachiko; Kikuchi Yuji; Nagamitsu Tohru; Masuma Rokuro; Sunazuka Toshiaki; Omura Satoshi
Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium.
Antimicrobial agents and chemotherapy 2005;49(8):3396-403.
2005: Uchida Ryuji; Imasato Rie; Yamaguchi Yuichi; Masuma Rokuro; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778.
The Journal of antibiotics 2005;58(6):397-404.
2005: Koyama Nobuhiro; Nagahiro Tomoko; Yamaguchi Yuichi; Ohshiro Taichi; Masuma Rokuro; Tomoda Hiroshi; Omura Satoshi
Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840.
The Journal of antibiotics 2005;58(5):338-45.
2005: Fukuda Takashi; Tomoda Hiroshi; Omura Satoshi
Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation.
The Journal of antibiotics 2005;58(5):315-21.
2005: Fukuda Takashi; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Omura Satoshi
Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 2005;58(5):309-14.
2005: Takahashi Atsushi; Inokoshi Junji; Chiba Harumi; Omura Satoshi; Tanaka Haruo
Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomycete.
Archives of biochemistry and biophysics 2005;437(2):233-40.
2005: Fukuda Takashi; Matsumoto Atsuko; Takahashi Yoko; Tomoda Hiroshi; Omura Satoshi
Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132.
The Journal of antibiotics 2005;58(4):252-9.
2005: Sunazuka Toshiaki; Shirahata Tatsuya; Tsuchiya Satoshi; Hirose Tomoyasu; Mori Ryuma; Harigaya Yoshihiro; Kuwajima Isao; Omura Satoshi
A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline.
Organic letters 2005;7(5):941-3.
2005: Yoshida Kiminari; Sunazuka Toshiaki; Nagai Kenichiro; Sugawara Akihiro; Cho Achim; Nagamitsu Tohru; Harigaya Yoshihiro; Otoguro Kazuhiko; Akagawa Kiyoko S; Omura Satoshi
Macrolides with promotive activity of monocyte to macrophage differentiation.
The Journal of antibiotics 2005;58(1):79-81.
2005: Shiomi Kazuro; Hatae Kenji; Hatano Hiroko; Matsumoto Atsuko; Takahashi Yoko; Jiang Cheng-Lin; Tomoda Hiroshi; Kobayashi Susumu; Tanaka Haruo; Omura Satoshi
A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031.
The Journal of antibiotics 2005;58(1):74-8.
2005: Shiomi Kazuro; Matsui Ryosuke; Isozaki Miki; Chiba Harumi; Sugai Takahiro; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Chiba Tomoko; Yan Hua; Kitamura Yoshihiro; Sugiura Wataru; Omura Satoshi; Tanaka Haruo
Fungal phenalenones inhibit HIV-1 integrase.
The Journal of antibiotics 2005;58(1):65-8.
2005: Shiomi Kazuro; Ui Hideaki; Suzuki Hideaki; Hatano Hiroko; Nagamitsu Tohru; Takano Daisuke; Miyadera Hiroko; Yamashita Tetsuo; Kita Kiyoshi; Miyoshi Hideto; Harder Achim; Tomoda Hiroshi; Omura Satoshi
A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I.
The Journal of antibiotics 2005;58(1):50-5.
2005: Rao Francesco V; Houston Douglas R; Boot Rolf G; Aerts Johannes M F G; Hodkinson Michael; Adams David J; Shiomi Kazuro; Omura Satoshi; van Aalten Daan M F
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.
Chemistry & biology 2005;12(1):65-76.
2004: Arai Masayoshi; Koizumi Yukio; Sato Hitoshi; Kawabe Takumi; Suganuma Masashi; Kobayashi Hidetaka; Tomoda Hiroshi; Omura Satoshi
Boromycin abrogates bleomycin-induced G2 checkpoint.
The Journal of antibiotics 2004;57(10):662-8.
2004: Sakano Yuichi; Shibuya Masaaki; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Omura Satoshi; Ebizuka Yutaka
Epohelmins A and B, novel lanosterol synthase inhibitors from a fungal strain FKI-0929.
The Journal of antibiotics 2004;57(9):564-8.
2004: Nagai Kenichiro; Shiomi Kazuro; Sunazuka Toshiaki; Harder Achim; Turberg Andreas; Omura Satoshi
Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives.
Bioorganic & medicinal chemistry letters 2004;14(16):4135-9.
2004: Koizumi Yukio; Arai Masayoshi; Tomoda Hiroshi; Omura Satoshi
Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.
The Journal of antibiotics 2004;57(7):415-20.
2004: Koizumi Yukio; Arai Masayoshi; Tomoda Hiroshi; Omura Satoshi
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization.
Biochimica et biophysica acta 2004;1693(1):47-55.
2004: Nagamitsu Tohru; Takano Daisuke; Fukuda Takeo; Otoguro Kazuhiko; Kuwajima Isao; Harigaya Yoshihiro; Omura Satoshi
Total synthesis of (-)-borrelidin.
Organic letters 2004;6(11):1865-7.
2004: Desaki Masashi; Okazaki Hitoshi; Sunazuka Toshiaki; Omura Satoshi; Yamamoto Kazuhiko; Takizawa Hajime
Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation.
Antimicrobial agents and chemotherapy 2004;48(5):1581-5.
2004: Arai Masayoshi; Sato Hitoshi; Kobayashi Hidetaka; Suganuma Masashi; Kawabe Takumi; Tomoda Hiroshi; Omura Satoshi
Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin alpha.
Biochemical and biophysical research communications 2004;317(3):817-22.
2004: Ping Xu; Takahashi Yoko; Seino Akio; Iwai Yuzuru; Omura Satoshi
Streptomyces scabrisporus sp. nov.
International journal of systematic and evolutionary microbiology 2004;54(Pt 2):577-81.
2004: Chiba Harumi; Inokoshi Junji; Nakashima Hideki; Omura Satoshi; Tanaka Haruo
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120.
Biochemical and biophysical research communications 2004;316(1):203-10.
2004: Fukuda Takashi; Arai Masayoshi; Tomoda Hiroshi; Omura Satoshi
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. II. Structure elucidation.
The Journal of antibiotics 2004;57(2):117-24.
2004: Fukuda Takashi; Arai Masayoshi; Yamaguchi Yuichi; Masuma Rokurou; Tomoda Hiroshi; Omura Satoshi
New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 2004;57(2):110-6.
2004: Tomoda Hiroshi; Ohbayashi Naomi; Morikawa Yuko; Kumagai Hidetoshi; Omura Satoshi
Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Biochimica et biophysica acta 2004;1636(1):22-8.
2004: Matsuda Daisuke; Namatame Ichiji; Tomoda Hiroshi; Kobayashi Susumu; Zocher Rainer; Kleinkauf Horst; Omura Satoshi
New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.
The Journal of antibiotics 2004;57(1):1-9.
2004: Nunome Shinyu; Ishiyama Aki; Kobayashi Miyuki; Otoguro Kazuhiko; Kiyohara Hiroaki; Yamada Haruki; Omura Satoshi
In vitro antimalarial activity of biflavonoids from Wikstroemia indica.
Planta medica 2004;70(1):76-8.
2004: Namatame Ichiji; Tomoda Hiroshi; Ishibashi Shun; Omura Satoshi
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):737-42.
2003: Nagai Kenichiro; Sunazuka Toshiaki; Shiomi Kazuro; Harder Achim; Turberg Andreas; Omura Satoshi
Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives.
Bioorganic & medicinal chemistry letters 2003;13(22):3943-6.
2003: Sakano Yuichi; Shibuya Masaaki; Matsumoto Atsuko; Takahashi Yoko; Tomoda Hiroshi; Omura Satoshi; Ebizuka Yutaka
Lanopylins A1, B1, A2 and B2, novel lanosterol synthase inhibitors from Streptomyces sp. K99-5041.
The Journal of antibiotics 2003;56(10):817-26.
2003: Matsumoto Atsuko; Takahashi Yoko; Shinose Mayumi; Seino Akio; Iwai Yuzuru; Omura Satoshi
Longispora albida gen. nov., sp. nov., a novel genus of the family Micromonosporaceae.
International journal of systematic and evolutionary microbiology 2003;53(Pt 5):1553-9.
2003: Takahashi Yoko; Katoh Shogo; Shikura Noriyasu; Tomoda Hiroshi; Omura Satoshi
Superoxide dismutase produced by soil bacteria increases bacterial colony growth from soil samples.
The Journal of general and applied microbiology 2003;49(4):263-6.
2003: Handa Masaki; Sunazuka Toshiaki; Sugawara Akihiro; Harigaya Yoshihiro; Otoguro Kazuhiko; Omura Satoshi
Total syntheses of the AChE inhibitors (-)-arisugacins F and G.
The Journal of antibiotics 2003;56(8):730-3.
2003: Otoguro Kazuhiko; Ui Hideaki; Ishiyama Aki; Kobayashi Miyuki; Togashi Hideaki; Takahashi Yoko; Masuma Rokuro; Tanaka Haruo; Tomoda Hiroshi; Yamada Haruki; Omura Satoshi
In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia.
The Journal of antibiotics 2003;56(8):727-9.
2003: Sunazuka Toshiaki; Yoshida Kiminari; Oohori Masako; Otoguro Kazuhiko; Harigaya Yoshihiro; Iwai Yuzuru; Akagawa Kiyoko S; Omura Satoshi
Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation.
The Journal of antibiotics 2003;56(8):721-4.
2003: Takahashi Yoko; Omura Satoshi
Isolation of new actinomycete strains for the screening of new bioactive compounds.
The Journal of general and applied microbiology 2003;49(3):141-54.
2003: Yamamoto Kazunobu; Hatano Hiroko; Arai Masayoshi; Shiomi Kazuro; Tomoda Hiroshi; Omura Satoshi
Structure elucidation of new monordens produced by Humicola sp. FO-2942.
The Journal of antibiotics 2003;56(6):533-8.
2003: Arai Masayoshi; Yamamoto Kazunobu; Namatame Ichiji; Tomoda Hiroshi; Omura Satoshi
New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942.
The Journal of antibiotics 2003;56(6):526-32.
2003: Fukuda Takashi; Kim Yong-Pil; Iizima Kousuke; Tomoda Hiroshi; Omura Satoshi
Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. II. Structure elucidation.
The Journal of antibiotics 2003;56(5):454-8.
2003: Kim Yong-Pil; Tomoda Hiroshi; Iizima Kousuke; Fukuda Takashi; Matsumoto Atsuko; Takahashi Yoko; Omura Satoshi
Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.
The Journal of antibiotics 2003;56(5):448-53.
2003: Ikeda Haruo; Ishikawa Jun; Hanamoto Akiharu; Shinose Mayumi; Kikuchi Hisashi; Shiba Tadayoshi; Sakaki Yoshiyuki; Hattori Masahira; Omura Satoshi
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.
Nature biotechnology 2003;21(5):526-31.
2003: Otoguro Kazuhiko; Ui Hideaki; Ishiyama Aki; Arai Noriko; Kobayashi Miyuki; Takahashi Yoko; Masuma Rokuro; Shiomi Kazuro; Yamada Haruki; Omura Satoshi
In vitro antimalarial activities of the microbial metabolites.
The Journal of antibiotics 2003;56(3):322-4.
2003: Shirahata Tatsuya; Sunazuka Toshiaki; Yoshida Kiminari; Yamamoto Daisuke; Harigaya Yoshihiko; Nagai Takayuki; Kiyohara Hiroaki; Yamada Haruki; Kuwajima Isao; Omura Satoshi
Total synthesis and adjuvant activity of all stereoisomers of pinellic acid.
Bioorganic & medicinal chemistry letters 2003;13(5):937-41.
2003: Tomoda Hiroshi; Tabata Noriko; Ohyama Yukako; Omura Satoshi
Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase.
The Journal of antibiotics 2003;56(1):24-9.
2003: Miyadera Hiroko; Shiomi Kazuro; Ui Hideaki; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Miyoshi Hideto; Osanai Arihiro; Kita Kiyoshi; Omura Satoshi
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):473-7.
2002: Namatame Ichiji; Matsuda Daisuke; Tomoda Hiroshi; Yamaguchi Yuichi; Masuma Rokuro; Kobayashi Susumu; Omura Satoshi
Selective production of fungal beauveriolide I or III by fermentation in amino acid-supplemented media.
The Journal of antibiotics 2002;55(12):1048-52.
2002: Shiomi Kazuro; Hatae Kenji; Yamaguchi Yuichi; Masuma Rokuro; Tomoda Hiroshi; Kobayashi Susumu; Omura Satoshi
New antibiotics miyakamides produced by a fungus.
The Journal of antibiotics 2002;55(11):952-61.
2002: Takahashi Yoko; Matsumoto Atsuko; Seino Akio; Ueno Junji; Iwai Yuzuru; Omura Satoshi
Streptomyces avermectinius sp. nov., an avermectin-producing strain.
International journal of systematic and evolutionary microbiology 2002;52(Pt 6):2163-8.
2002: Hayashi Masahiko; Rho Mun-Chual; Enomoto Akiko; Fukami Akiko; Kim Yong-Pil; Kikuchi Yuji; Sunazuka Toshiaki; Hirose Tomoyasu; Komiyama Kanki; Omura Satoshi
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):14728-33.
2002: Otoguro Kazuhiko; Ishiyama Aki; Ui Hideaki; Kobayashi Miyuki; Manabe Chizu; Yan Guan; Takahashi Yoko; Tanaka Haruo; Yamada Haruki; Omura Satoshi
In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia.
The Journal of antibiotics 2002;55(9):832-4.
2002: Houston Douglas R; Shiomi Kazuro; Arai Noriko; Omura Satoshi; Peter Martin G; Turberg Andreas; Synstad Bjørnar; Eijsink Vincent G H; van Aalten Daan M F
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9127-32.
2002: Fukami Akiko; Iijima Kousuke; Hayashi Masahiko; Komiyama Kanki; Omura Satoshi
Macrosphelide B suppressed metastasis through inhibition of adhesion of sLe(x)/E-selectin molecules.
Biochemical and biophysical research communications 2002;291(4):1065-70.
2002: Arai Masayoshi; Tomoda Hiroshi; Okuda Takako; Wang Haiyan; Tabata Noriko; Masuma Rokuro; Yamaguchi Yuichi; Omura Satoshi
Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromycesflavus FKI-0076.
The Journal of antibiotics 2002;55(2):172-80.
2002: Hirose Tomoyasu; Sunazuka Toshiaki; Shirahata Tatsuya; Yamamoto Daisuke; Harigaya Yoshihiro; Kuwajima Isao; Omura Satoshi
Short total synthesis of (+)-madindolines A and B.
Organic letters 2002;4(4):501-3.
2002: Sunazuka Toshiaki; Handa Masaki; Nagai Kenichiro; Shirahata Tatsuya; Harigaya Yoshihiro; Otoguro Kazuhiko; Kuwajima Isao; Omura Satoshi
The first total synthesis of (+/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase.
Organic letters 2002;4(3):367-9.
2001: Uchida R; Tomoda H; Arai M; Omura S
Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus.
The Journal of antibiotics 2001;54(11):882-9.
2001: Chiba H; Asanuma S; Okamoto M; Inokoshi J; Tanaka H; Fujita K; Omura S
A simple screening system for anti-HIV drugs: syncytium formation assay using T-cell line tropic and macrophage tropic HIV env expressing cell lines--establishment and validation.
The Journal of antibiotics 2001;54(10):818-26.
2001: Omura S; Ikeda H; Ishikawa J; Hanamoto A; Takahashi C; Shinose M; Takahashi Y; Horikawa H; Nakazawa H; Osonoe T; Kikuchi H; Shiba T; Sakaki Y; Hattori M
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12215-20.
2001: Ikeda H; Nonomiya T; Omura S
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
Journal of industrial microbiology & biotechnology 2001;27(3):170-6.
2001: Tajima K; Takahashi Y; Seino A; Iwai Y; Omura S
Description of two novel species of the genus Kitasatospora Omura et al. 1982, Kitasatospora cineracea sp. nov. and Kitasatospora niigatensis sp. nov.
International journal of systematic and evolutionary microbiology 2001;51(Pt 5):1765-71.
2001: Otoguro K; Kohana A; Manabe C; Ishiyama A; Ui H; Shiomi K; Yamada H; Omura S
Potent antimalarial activities of polyether antibiotic, X-206.
The Journal of antibiotics 2001;54(8):658-63.
2001: Zhang H; Tomoda H; Tabata N; Miura H; Namikoshi M; Yamaguchi Y; Masuma R; Omura S
Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012.
The Journal of antibiotics 2001;54(8):635-41.
2001: Takano D; Nagamitsu T; Ui H; Shiomi K; Yamaguchi Y; Masuma R; Kuwajima I; Omura S
Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor.
Organic letters 2001;3(15):2289-91.
2001: Handa M; Sunazuka T; Nagai K; Kimura R; Otoguro K; Harigaya Y; Omura S
Determination of absolute stereochemistries of arisugacin F and Territrem B, novel acetylcholinesterase inhibitors.
The Journal of antibiotics 2001;54(4):386-91.
2001: Handa M; Sunazuka T; Nagai K; Kimura R; Shirahata T; Tian Z M; Otoguro K; Harigaya Y; Omura S
Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity.
The Journal of antibiotics 2001;54(4):382-5.
2001: Chiba H; Inokoshi J; Okamoto M; Asanuma S; Matsuzaki Ki; Iwama M; Mizumoto K; Tanaka H; Oheda M; Fujita K; Nakashima H; Shinose M; Takahashi Y; Omura S
Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities.
Biochemical and biophysical research communications 2001;282(2):595-601.
2001: Enomoto Y; Shiomi K; Matsumoto A; Takahashi Y; Iwai Y; Harder A; Kölbl H; Woodruff H B; Omura S
Isolation of a new antibiotic oligomycin G produced by Streptomyces sp. WK-6150.
The Journal of antibiotics 2001;54(3):308-13.
2001: Ui H; Shiomi K; Yamaguchi Y; Masuma R; Nagamitsu T; Takano D; Sunazuka T; Namikoshi M; Omura S
Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.
The Journal of antibiotics 2001;54(3):234-8.
2001: Inokoshi J; Chiba H; Asanuma S; Takahashi A; Omura S; Tanaka H
Molecular cloning of actinohivin, a novel anti-HIV protein from an actinomycete, and its expression in Escherichia coli.
Biochemical and biophysical research communications 2001;281(5):1261-5.
2001: Inesawa H; Akagawa K; Ohori M; Sunatsuka T; Otoguro K; Omura S
[Effects of macrolide antibiotics on immune cells derived from human peripheral blood]
The Japanese journal of antibiotics 2001;54 Suppl A():139-42.
2001: Omura S; Miyadera H; Ui H; Shiomi K; Yamaguchi Y; Masuma R; Nagamitsu T; Takano D; Sunazuka T; Harder A; Kölbl H; Namikoshi M; Miyoshi H; Sakamoto K; Kita K
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):60-2.
2000: Gouda H; Sunazuka T; Omura S; Hirono S
Three-dimensional structure-activity relationship analysis between motilin and motilide using conformational analysis and a novel molecular superposing method.
Chemical & pharmaceutical bulletin 2000;48(11):1835-7.
2000: Oohori M; Otoguro K; Sunazuka T; Kunihiko S; Iwai Y; Omura S
Effect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships.
The Journal of antibiotics 2000;53(10):1219-22.
2000: Fukami A; Nakamura T; Kim Y P; Shiomi K; Hayashi M; Nagai T; Yamada H; Komiyama K; Omura S
A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050.
The Journal of antibiotics 2000;53(10):1215-8.
2000: Fukami A; Nakamura T; Kawaguchi K; Rho M C; Matsumoto A; Takahashi Y; Shiomi K; Hayashi M; Komiyama K; Omura S
A new antimicrobial antibiotic from Actinoplanes capillaceus sp. K95-5561T.
The Journal of antibiotics 2000;53(10):1212-4.
2000: Rho M C; Hayashi M; Fukami A; Obata R; Sunazuka T; Tomoda H; Komiyama K; Omura S
Reversal of multidrug resistance by 7-O-benzoylpyripyropene A in multidrug-resistant tumor cells.
The Journal of antibiotics 2000;53(10):1201-6.
2000: Arai N; Shiomi K; Yamaguchi Y; Masuma R; Iwai Y; Turberg A; Kölbl H; Omura S
Argadin, a new chitinase inhibitor, produced by Clonostachys sp. FO-7314.
Chemical & pharmaceutical bulletin 2000;48(10):1442-6.
2000: Matsumoto A; Takahashi Y; Kudo T; Seino A; Iwai Y; Omura S
Actinoplanes capillaceus sp. nov., a new species of the genus Actinoplanes.
Antonie van Leeuwenhoek 2000;78(2):107-15.
2000: Arai N; Shiomi K; Iwai Y; Omura S
Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. II. Isolation, physico-chemical properties, and structure elucidation.
The Journal of antibiotics 2000;53(6):609-14.
2000: Omura S; Arai N; Yamaguchi Y; Masuma R; Iwai Y; Namikoshi M; Turberg A; Kölbl H; Shiomi K
Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities.
The Journal of antibiotics 2000;53(6):603-8.
2000: Obata R; Sunazuka T; Otoguro K; Tomoda H; Harigaya Y; Omura S
Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.
Bioorganic & medicinal chemistry letters 2000;10(12):1315-6.
2000: Obata R; Sunazuka T; Harigaya Y; Hayashi M; Rho M C; Tomoda H; Omura S
Structure-activity relationships study of pyripyropenes: reversal of cancer cell multidrug resistance.
The Journal of antibiotics 2000;53(4):422-5.
2000: Otoguro K; Shiomi K; Yamaguchi Y; Arai N; Sunazuka T; Masuma R; Iwai Y; Omura S
Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp. FO-4259-11.
The Journal of antibiotics 2000;53(1):50-7.
2000: Namatame I; Tomoda H; Arai M; Omura S
Effect of fungal metabolites cytochalasans on lipid droplet formation in mouse macrophages.
The Journal of antibiotics 2000;53(1):19-25.
2000: Desaki M; Takizawa H; Ohtoshi T; Kasama T; Kobayashi K; Sunazuka T; Omura S; Yamamoto K; Ito K
Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells.
Biochemical and biophysical research communications 2000;267(1):124-8.
1999: Tabata N; Tomoda H; Omura S
Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. II. Structure elucidation.
The Journal of antibiotics 1999;52(12):1108-13.
1999: Tomoda H; Tabata N; Shinose M; Takahashi Y; Woodruff H B; Omura S
Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. I. Production, isolation and biological properties.
The Journal of antibiotics 1999;52(12):1101-7.
1999: Inokoshi J; Shiomi K; Masuma R; Tanaka H; Yamada H; Omura S
Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
The Journal of antibiotics 1999;52(12):1095-100.
1999: Tabata N; Tomoda H; Yamaguchi Y; Masuma R; Bamberger M J; Omura S
Inhibition of cholesteryl ester transfer protein by fungal metabolites, L681,512.
The Journal of antibiotics 1999;52(11):1042-5.
1999: Tomoda H; Ohbayashi N; Kumagai H; Hashizume H; Sunazuka T; Omura S
Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of beta-lactone DU-6622.
Biochemical and biophysical research communications 1999;265(2):536-40.
1999: Tanaka Y; Kamei K; Otoguro K; Omura S
Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.
The Journal of antibiotics 1999;52(10):880-8.
1999: Tomoda H; Namatame I; Tabata N; Kawaguchi K; Si S; Omura S
Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages.
The Journal of antibiotics 1999;52(10):857-61.
1999: Tomoda H; Namatame I; Si S; Kawaguchi K; Masuma R; Namikoshi M; Omura S
Phenochalasins, inhibitors of lipid droplet formation in mouse macrophages, produced by Phomopsis sp. FT-0211.
The Journal of antibiotics 1999;52(10):851-6.
1999: Tabata N; Ohyama Y; Tomoda H; Abe T; Namikoshi M; Omura S
Structure elucidation of roselipins, inhibitors of diacylglycerol acyltransferase produced by Gliocladium roseum KF-1040.
The Journal of antibiotics 1999;52(9):815-26.
1999: Matsumoto T; Ishiyama A; Yamaguchi Y; Masuma R; Ui H; Shiomi K; Yamada H; Omura S
Novel cyclopentanone derivatives pentenocins A and B with interleukin-1beta converting enzyme inhibitory activity, produced by Trichoderma hamatum FO-6903.
The Journal of antibiotics 1999;52(8):754-7.
1999: Tomoda H; Ohyama Y; Abe T; Tabata N; Namikoshi M; Yamaguchi Y; Masuma R; Omura S
Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040.
The Journal of antibiotics 1999;52(8):689-94.
1999: Ikeda H; Nonomiya T; Usami M; Ohta T; Omura S
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9509-14.
1999: Takahashi Y; Seino A; Iwai Y; Omura S
Taxonomic study and morphological differentiation of an actinomycete genus, Kitasatospora.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1999;289(3):265-84.
1999: Omura S; Tomoda H; Tabata N; Ohyama Y; Abe T; Namikoshi M
Roselipins, novel fungal metabolites having a highly methylated fatty acid modified with a mannose and an arabinitol.
The Journal of antibiotics 1999;52(6):586-9.
1999: Uchida R; Tomoda H; Dong Y; Omura S
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436.
The Journal of antibiotics 1999;52(6):572-4.
1999: Fukami A; Taniguchi Y; Nakamura T; Rho M C; Kawaguchi K; Hayashi M; Komiyama K; Omura S
New members of the macrosphelides from Microsphaeropsis sp. FO-5050 IV.
The Journal of antibiotics 1999;52(5):501-4.
1999: Inokoshi J; Katagiri M; Arima S; Tanaka H; Hayashi M; Kim Y B; Furumai R; Yoshida M; Horinouchi S; Omura S
Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I.
Biochemical and biophysical research communications 1999;256(2):372-6.
1999: Tomoda H; Matsushima C; Tabata N; Namatame I; Tanaka H; Bamberger M J; Arai H; Fukazawa M; Inoue K; Omura S
Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones.
The Journal of antibiotics 1999;52(2):160-70.
1999: Namatame I; Tomoda H; Arai H; Inoue K; Omura S
Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C.
Journal of biochemistry 1999;125(2):319-27.
1999: Sunazuka T; Takizawa H; Desaki M; Suzuki K; Obata R; Otoguro K; Omura S
Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells.
The Journal of antibiotics 1999;52(1):71-4.
1999: Omura S; Enomoto Y; Shinose M; Takahashi Y; Iwai Y; Shiomi K
Isolation and structure of a new antibiotic viridomycin F produced by Streptomyces sp. K96-0188.
The Journal of antibiotics 1999;52(1):61-4.
1999: Tabata N; Tomoda H; Zhang H; Uchida R; Omura S
Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. II. Structure elucidation.
The Journal of antibiotics 1999;52(1):34-9.
1999: Zhang H; Tomoda H; Tabata N; Oohori M; Shinose M; Takahashi Y; Omura S
Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties.
The Journal of antibiotics 1999;52(1):29-33.
1999: Namatame I; Tomoda H; Tabata N; Si S; Omura S
Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages.
The Journal of antibiotics 1999;52(1):7-12.
1999: Namatame I; Tomoda H; Si S; Yamaguchi Y; Masuma R; Omura S
Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979.
The Journal of antibiotics 1999;52(1):1-6.
1998: Matsuzaki K; Tahara H; Inokoshi J; Tanaka H; Masuma R; Omura S
New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding.
The Journal of antibiotics 1998;51(11):1004-11.
1998: Tabata N; Tomoda H; Omura S
Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. II. Structure elucidation of erabulenols A and B.
The Journal of antibiotics 1998;51(7):624-8.
1998: Tomoda H; Tabata N; Masuma R; Si S Y; Omura S
Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. I.Production, isolation and biological properties.
The Journal of antibiotics 1998;51(7):618-23.
1998: Ikeda H; Omura S
[Combinatorial biosynthesis: engineered biosynthesis of polykelide compounds]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(9):1265-77.
1998: Tanaka Y; Fang F; Zhang C H; Zhang X W; Omura S
Heme-dependent radical generation from antimalarial fungal metabolites, radicicol and heptelidic acid.
The Journal of antibiotics 1998;51(4):451-3.
1998: Tanaka Y; Shiomi K; Kamei K; Sugoh-Hagino M; Enomoto Y; Fang F; Yamaguchi Y; Masuma R; Zhang C G; Zhang X W; Omura S
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites.
The Journal of antibiotics 1998;51(2):153-60.
1998: Ikeda H; Wang L R; Ohta T; Inokoshi J; Omura S
Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis.
Gene 1998;206(2):175-80.
1997: Takamatsu S; Kim Y P; Enomoto A; Hayashi M; Tanaka H; Komiyama K; Omura S
Madindolines, novel inhibitors of IL-6 activity from streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation.
The Journal of antibiotics 1997;50(12):1069-72.
1997: Fang F; Ui H; Shiomi K; Masuma R; Yamaguchi Y; Zhang C G; Zhang X W; Tanaka Y; Omura S
Two new components of the aspochalasins produced by Aspergillus sp.
The Journal of antibiotics 1997;50(11):919-25.
1997: Otoguro K; Kuno F; Omura S
Arisugacins, selective acetylcholinesterase inhibitors of microbial origin.
Pharmacology & therapeutics 1997;76(1-3):45-54.
1997: Arai N; Shiomi K; Takamatsu S; Komiyama K; Shinose M; Takahashi Y; Tanaka Y; Iwai Y; Liu J R; Omura S
Amphistin, a new melanogenesis inhibitor, produced by an actinomycete.
The Journal of antibiotics 1997;50(10):808-14.
1997: Tabata N; Ito M; Tomoda H; Omura S
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Phytochemistry 1997;46(4):683-7.
1997: Sunazuka T; Hirose T; Tian Z M; Uchida R; Shiomi K; Harigaya Y; Omura S
Syntheses and absolute structures of novel protein farnesyltransferase inhibitors, kurasoins A and B.
The Journal of antibiotics 1997;50(5):453-5.
1997: Sunazuka T; Tian Z M; Harigaya Y; Takamatsu S; Hayashi M; Komiyama K; Omura S
Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis.
The Journal of antibiotics 1997;50(3):274-5.
1997: Obata R; Sunazuka T; Tian Z; Tomoda H; Harigaya Y; Omura S
Chemical modification and structure-activity relationships of pyripyropenes. 3. Synthetic conversion of pyridine-pyrone moiety.
The Journal of antibiotics 1997;50(3):229-36.
1997: Tanaka Y; Yoshida H; Enomoto Y; Shiomi K; Shinose M; Takahashi Y; Liu J R; Omura S
Malolactomycins C and D, new 40-membered macrolides active against Botrytis.
The Journal of antibiotics 1997;50(3):194-200.
1997: Matsuzaki K; Ogino T; Sunazuka T; Tanaka H; Omura S
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.
The Journal of antibiotics 1997;50(1):66-9.
1997: Tanaka H; Matsuzaki K; Nakashima H; Ogino T; Matsumoto A; Ikeda H; Woodruff H B; Omura S
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. I. Taxonomy, fermentation, isolation, and physico-chemical properties and biological activities.
The Journal of antibiotics 1997;50(1):58-65.
1996: Uchida R; Shiomi K; Inokoshi J; Tanaka H; Iwai Y; Omura S
Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929.
The Journal of antibiotics 1996;49(12):1278-80.
1996: Obata R; Sunazuka T; Kato Y; Tomoda H; Harigaya Y; Omura S
Chemical modification and structure-activity relationships of pyripyropenes. 2. 1,11-Cyclic analogs.
The Journal of antibiotics 1996;49(11):1149-56.
1996: Obata R; Sunazuka T; Li Z; Tian Z; Harigaya Y; Tabata N; Tomoda H; Omura S
Chemical modification and structure-activity relationships of pyripyropenes. 1. Modification at the four hydroxyl groups.
The Journal of antibiotics 1996;49(11):1133-48.
1996: Hayashi M; Kim Y P; Takamatsu S; Enomoto A; Shinose M; Takahashi Y; Tanaka H; Komiyama K; Omura S
Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities.
The Journal of antibiotics 1996;49(11):1091-5.
1996: Yamada R; Seto M; Sasaki Y; Sunazuka T; Harigaya Y; Iwai Y; Omura S
Synthesis and anti-platelet aggregation activity of water-soluble staurosporine derivatives.
The Journal of antibiotics 1996;49(10):1070-2.
1996: Tanaka Y; Matsuzaki K; Zhong C L; Yoshida H; Kawakubo T; Masuma R; Tanaka H; Omura S
Dechlorogeodin and its new dihydro derivatives, fungal metabolites with herbicidal activity.
The Journal of antibiotics 1996;49(10):1056-9.
1996: Miura H; Tomoda H; Miura K; Takishima K; Omura S
Lactacystin increases LDL receptor level on HepG2 cells.
Biochemical and biophysical research communications 1996;227(3):684-7.
1996: Uchida R; Shiomi K; Inokoshi J; Masuma R; Kawakubo T; Tanaka H; Iwai Y; Omura S
Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. I. Producing strain, fermentation, isolation, and biological activities.
The Journal of antibiotics 1996;49(9):932-4.
1996: Tomoda H; Yamaguchi Y; Tabata N; Kobayashi T; Masuma R; Tanaka H; Omura S
Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969.
The Journal of antibiotics 1996;49(9):929-31.
1996: Uchida R; Shiomi K; Sunazuka T; Inokoshi J; Nishizawa A; Hirose T; Tanaka H; Iwai Y; Omura S
Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.
The Journal of antibiotics 1996;49(9):886-9.
1996: Kuno F; Shiomi K; Otoguro K; Sunazuka T; Omura S
Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation.
The Journal of antibiotics 1996;49(8):748-51.
1996: Kuno F; Otoguro K; Shiomi K; Iwai Y; Omura S
Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity.
The Journal of antibiotics 1996;49(8):742-7.
1996: Sun X L; Takayanagi H; Matsuzaki K; Tanaka H; Furuhata K; Omura S
Synthesis and inhibitory activities of isochromophilone analogues against gp120-CD4 binding.
The Journal of antibiotics 1996;49(7):689-92.
1996: Takamatsu S; Kim Y P; Komiya T; Sunazuka T; Hayashi M; Tanaka H; Komiyama K; Omura S
Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation.
The Journal of antibiotics 1996;49(7):635-8.
1996: Hayashi M; Kim Y P; Takamatsu S; Preeprame S; Komiya T; Masuma R; Tanaka H; Komiyama K; Omura S
Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I. Taxonomy, fermentation, isolation and biological activities.
The Journal of antibiotics 1996;49(7):631-4.
1996: Inatomi N; Sato F; Marui S; Itoh Z; Omura S
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs.
Japanese journal of pharmacology 1996;71(1):29-38.
1996: Takamatsu S; Kim Y P; Hayashi M; Komiyama K; Imokawa G; Omura S
A new inhibitor of melanogenesis, albocycline K3, produced by Streptomyces sp. OH-3984.
The Journal of antibiotics 1996;49(5):485-6.
1996: Uchida R; Shiomi K; Inokoshi J; Sunazuka T; Tanaka H; Iwai Y; Takayanagi H; Omura S
Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis.
The Journal of antibiotics 1996;49(5):418-24.
1996: Omura S; Inokoshi J; Uchida R; Shiomi K; Masuma R; Kawakubo T; Tanaka H; Iwai Y; Kosemura S; Yamamura S
Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.
The Journal of antibiotics 1996;49(5):414-7.
1996: Omura S; Takeshima H
[Lactacystin: a tool for elucidation of proteasome functions]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1996;41(4):327-36.
1996: Tomoda H; Tabata N; Yang D J; Namatame I; Tanaka H; Omura S; Kaneko T
Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus. IV. Structure elucidation of pyripyropenes M to R.
The Journal of antibiotics 1996;49(3):292-8.
1996: Tabata N; Tomoda H; Iwai Y; Omura S
Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888.
The Journal of antibiotics 1996;49(3):267-71.
1996: Yang D J; Tomoda H; Tabata N; Masuma R; Omura S
New isochromophilones VII and VIII produced by Penicillium sp. FO-4164.
The Journal of antibiotics 1996;49(3):223-9.
1996: Morikawa Y; Hinata S; Tomoda H; Goto T; Nakai M; Aizawa C; Tanaka H; Omura S
Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding.
The Journal of biological chemistry 1996;271(5):2868-73.
1996: Takamatsu S; Kim Y P; Hayashi M; Hiraoka H; Natori M; Komiyama K; Omura S
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physiochemical properties and structural elucidation.
The Journal of antibiotics 1996;49(1):95-8.
1996: Enomoto Y; Shiomi K; Hayashi M; Masuma R; Kawakubo T; Tomosawa K; Iwai Y; Omura S
Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372.
The Journal of antibiotics 1996;49(1):50-3.
1995: Hayashi M; Kim Y P; Hiraoka H; Natori M; Takamatsu S; Kawakubo T; Masuma R; Komiyama K; Omura S
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.
The Journal of antibiotics 1995;48(12):1435-9.
1995: Tanaka H; Katagiri M; Arima S; Matsuzaki K; Inokoshi J; Omura S
Neuronal differentiation of Neuro 2a cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid.
Biochemical and biophysical research communications 1995;216(1):291-7.
1995: Takamatsu S; Kim Y P; Hayashi M; Furuhata K; Takayanagi H; Komiyama K; Woodruff H B; Omura S
Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. II. Physico-chemical properties and structural elucidation.
The Journal of antibiotics 1995;48(10):1090-4.
1995: Komiyama K; Takamatsu S; Kim Y P; Matsumoto A; Takahashi Y; Hayashi M; Woodruff H B; Omura S
Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. I. Taxonomy, fermentation, isolation and biological characteristics.
The Journal of antibiotics 1995;48(10):1086-9.
1995: Tomoda H; Tabata N; Ito M; Omura S
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C.
The Journal of antibiotics 1995;48(9):942-7.
1995: Tomoda H; Ito M; Tabata N; Masuma R; Yamaguchi Y; Omura S
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties.
The Journal of antibiotics 1995;48(9):937-41.
1995: Tomoda H; Tabata N; Yang D J; Takayanagi H; Omura S
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.
The Journal of antibiotics 1995;48(8):793-804.
1995: Obata R; Sunazuka T; Li Z; Tomoda H; Omura S
Structure-activity relationships of pyripyropenes fungal acyl-CoA: cholesterol acyltransferase inhibitors.
The Journal of antibiotics 1995;48(7):749-50.
1995: Nagamitsu T; Sunazuka T; Stump H; Obata R; Arima S; Matsuzaki K; Tanaka H; Omura S
Structure-activity relationships of lactacystin, the first non-protein neurotrophic factor.
The Journal of antibiotics 1995;48(7):747-8.
1995: Omura S; Kuno F; Otoguro K; Sunazuka T; Shiomi K; Masuma R; Iwai Y
Arisugacin, a novel and selective inhibitor of acetylcholinesterase from Penicillium sp. FO-4259.
The Journal of antibiotics 1995;48(7):745-6.
1995: Tanaka Y; Sugoh M; Ji W; Iwabuchi J; Yoshida H; Omura S
Screening method for cellulose biosynthesis inhibitors with herbicidal activity.
The Journal of antibiotics 1995;48(7):720-4.
1995: Shiomi K; Arai N; Shinose M; Takahashi Y; Yoshida H; Iwabuchi J; Tanaka Y; Omura S
New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.
The Journal of antibiotics 1995;48(7):714-9.
1995: Matsuzaki K; Tanaka H; Omura S
Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation.
The Journal of antibiotics 1995;48(7):708-13.
1995: Matsuzaki K; Ikeda H; Masuma R; Tanaka H; Omura S
Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. I. Screening, taxonomy, fermentation, isolation and biological activity.
The Journal of antibiotics 1995;48(7):703-7.
1995: Arai N; Shiomi K; Tomoda H; Tabata N; Yang D J; Masuma R; Kawakubo T; Omura S
Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216.
The Journal of antibiotics 1995;48(7):696-702.
1995: Ikeda H; Omura S
Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component.
The Journal of antibiotics 1995;48(7):549-62.
1995: Omura S; Sasaki Y; Iwai Y; Takeshima H
Staurosporine, a potentially important gift from a microorganism.
The Journal of antibiotics 1995;48(7):535-48.
1995: Tomoda H; Tabata N; Yang D J; Takayanagi H; Nishida H; Omura S; Kaneko T
Pyripyropenes, Novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L.
The Journal of antibiotics 1995;48(6):495-503.
1995: Kakinuma S; Ikeda H; Takada Y; Tanaka H; Hopwood D A; Omura S
Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensis.
The Journal of antibiotics 1995;48(6):484-7.
1995: Yamada H; Shiomi K; Xu Q; Nagai T; Shibata M; Oya I; Takahashi Y; Omura S
New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186.
The Journal of antibiotics 1995;48(3):205-10.
1995: Tabata N; Tomoda H; Iwai Y; Omura S
Arohynapene D, a new anticoccidial agent produced by Penicillium sp. FO-2295.
The Journal of antibiotics 1995;48(1):83-4.
1995: Pang C H; Matsuzaki K; Ikeda H; Tanaka H; Omura S
Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis.
The Journal of antibiotics 1995;48(1):59-66.
1995: Tabata N; Tomoda H; Masuma R; Iwai Y; Omura S
Fudecalone, a new anticoccidial agent produced by Penicillium sp. FO-2030.
The Journal of antibiotics 1995;48(1):53-8.
1995: Huang X H; Nishida H; Tomoda H; Tabata N; Shiomi K; Yang D J; Takayanagi H; Omura S
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.
The Journal of antibiotics 1995;48(1):5-11.
1995: Huang X H; Tomoda H; Nishida H; Masuma R; Omura S
Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties.
The Journal of antibiotics 1995;48(1):1-4.
1994: Yoshida H; Arai N; Sugoh M; Iwabuchi J; Shiomi K; Shinose M; Tanaka Y; Omura S
4-chlorothreonine, a herbicidal antimetabolite produced by Streptomyces sp. OH-5093.
The Journal of antibiotics 1994;47(10):1165-6.
1994: Shiomi K; Haneda K; Tomoda H; Iwai Y; Omura S
Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. II. Structure elucidation of cytosaminomycins A, B, C and D.
The Journal of antibiotics 1994;47(7):782-6.
1994: Haneda K; Shinose M; Seino A; Tabata N; Tomoda H; Iwai Y; Omura S
Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. I. Taxonomy, production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1994;47(7):774-81.
1994: Inokoshi J; Tomoda H; Hashimoto H; Watanabe A; Takeshima H; Omura S
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene.
Molecular & general genetics : MGG 1994;244(1):90-6.
1994: Kim Y K; Tomoda H; Nishida H; Sunazuka T; Obata R; Omura S
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.
The Journal of antibiotics 1994;47(2):154-62.
1994: Tomoda H; Kim Y K; Nishida H; Masuma R; Omura S
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties.
The Journal of antibiotics 1994;47(2):148-53.
1994: Masuma R; Tabata N; Tomoda H; Haneda K; Iwai Y; Omura S
Arohynapenes A and B, new anticoccidial agents produced by Penicillium sp. Taxonomy, fermentation, and structure elucidation.
The Journal of antibiotics 1994;47(1):46-53.
1993: Tabata N; Tomoda H; Iwai Y; Omura S
Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. II. Structure elucidation.
The Journal of antibiotics 1993;46(12):1854-8.
1993: Tabata N; Tomoda H; Masuma R; Haneda K; Iwai Y; Omura S
Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. I. Production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1993;46(12):1849-53.
1993: Komiyama K; Otoguro K; Segawa T; Shiomi K; Yang H; Takahashi Y; Hayashi M; Otani T; Omura S
A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.
The Journal of antibiotics 1993;46(11):1666-71.
1993: Takamatsu S; Rho M; Hayashi M; Komiyama K; Tanaka H; Omura S; Imokawa G
New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation.
The Journal of antibiotics 1993;46(10):1526-9.
1993: Komiyama K; Takamatsu S; Takahashi Y; Shinose M; Hayashi M; Tanaka H; Iwai Y; Omura S; Imokawa G
New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.
The Journal of antibiotics 1993;46(10):1520-5.
1993: Tanaka Y; Kanaya I; Shiomi K; Tanaka H; Omura S
Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. II. Isolation, physico-chemical properties, and structural elucidation.
The Journal of antibiotics 1993;46(8):1214-8.
1993: Tanaka Y; Kanaya I; Takahashi Y; Shinose M; Tanaka H; Omura S
Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. I. Discovery, taxonomy of producing microorganism, fermentation, and biological activity.
The Journal of antibiotics 1993;46(8):1208-13.
1993: Tomoda H; Omura S
[Triacsins, inhibitors of fatty acid activating enzyme]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(11):1929-37.
1993: Omura S; Inatomi N; Itoh Z
[Motilide, motilin-like macrolides]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(11):1881-90.
1993: Takeshima H; Omura S
[Inhibitor for protein-farnesylation]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(11):1695-703.
1993: Sunazuka T; Tabata N; Nagamitsu T; Tomoda H; Omura S
Synthesis of diolmycin analogs and their anticoccidial activities.
The Journal of antibiotics 1993;46(7):1178-80.
1993: Tabata N; Sunazuka T; Tomoda H; Nagamitsu T; Iwai Y; Omura S
Diolmycins, new anticoccidial agents produced by Streptomyces sp. II. Structure elucidation of diolmycins A1, A2, B1 and B2, and synthesis of diolmycin A1.
The Journal of antibiotics 1993;46(5):762-9.
1993: Tabata N; Tomoda H; Takahashi Y; Haneda K; Iwai Y; Woodruff H B; Omura S
Diolmycins, new anticoccidial agents produced by Streptomyces sp. I. Production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1993;46(5):756-61.
1993: Tabata N; Suzumura Y; Tomoda H; Masuma R; Haneda K; Kishi M; Iwai Y; Omura S
Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1993;46(5):749-55.
1993: Ikeda H; Takada Y; Pang C H; Tanaka H; Omura S
Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis.
Journal of bacteriology 1993;175(7):2077-82.
1993: Tomoda H; Omura S
Lipid metabolism inhibitors of microbial origin.
The Kitasato archives of experimental medicine 1993;65 Suppl():1-12.
1993: Shiomi K; Yang H; Inokoshi J; Van der Pyl D; Nakagawa A; Takeshima H; Omura S
Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E.
The Journal of antibiotics 1993;46(2):229-34.
1993: Omura S; Van der Pyl D; Inokoshi J; Takahashi Y; Takeshima H
Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity.
The Journal of antibiotics 1993;46(2):222-8.
1992: Ishii-Karakasa I; Iwase H; Hotta K; Tanaka Y; Omura S
Partial purification and characterization of an endo-alpha-N-acetylgalactosaminidase from the culture medium of Streptomyces sp. OH-11242.
The Biochemical journal 1992;288 ( Pt 2)():475-82.
1992: Van der Pyl D; Inokoshi J; Shiomi K; Yang H; Takeshima H; Omura S
Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin.
The Journal of antibiotics 1992;45(11):1802-5.
1992: Nishida H; Huang X H; Tomoda H; Omura S
Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B.
The Journal of antibiotics 1992;45(10):1669-76.
1992: Tomoda H; Huang X H; Cao J; Nishida H; Nagao R; Okuda S; Tanaka H; Omura S; Arai H; Inoue K
Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics.
The Journal of antibiotics 1992;45(10):1626-32.
1992: Inokoshi J; Takeshima H; Ikeda H; Omura S
Cloning and sequencing of the aculeacin A acylase-encoding gene from Actinoplanes utahensis and expression in Streptomyces lividans.
Gene 1992;119(1):29-35.
1992: Omura S
Thom Award Lecture. Trends in the search for bioactive microbial metabolites.
Journal of industrial microbiology 1992;10(3-4):135-56.
1992: Tomoda H; Nishida H; Huang X H; Masuma R; Kim Y K; Omura S
New cyclodepsipeptides, enniatins D, E and F produced by Fusarium sp. FO-1305.
The Journal of antibiotics 1992;45(8):1207-15.
1992: Tomoda H; Huang X H; Nishida H; Masuma R; Kim Y K; Omura S
Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. I. Production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1992;45(8):1202-6.
1992: Sunazuka T; Tsuzuki K; Kumagai H; Tomoda H; Tanaka H; Nagashima H; Hashizume H; Omura S
Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.
The Journal of antibiotics 1992;45(7):1139-47.
1992: Omura S
The expanded horizon for microbial metabolites--a review.
Gene 1992;115(1-2):141-9.
1992: Kumagai H; Tomoda H; Omura S
Biosynthesis of antibiotic 1233A (F-244) and preparation of [14C]1233A.
The Journal of antibiotics 1992;45(4):563-7.
1991: Kakinuma S; Takada Y; Ikeda H; Tanaka H; Omura S; Hopwood D A
Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer.
The Journal of antibiotics 1991;44(9):995-1005.
1991: Takahashi Y; Seki Y; Iwai Y; Omura S
Taxonomic properties of five Kitasatosporia strains isolated by a new method.
The Kitasato archives of experimental medicine 1991;64(2-3):123-32.
1991: Funayama S; Ishibashi M; Komiyama K; Omura S
A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation.
The Journal of antibiotics 1991;44(8):819-23.
1991: Komiyama K; Funayama S; Anraku Y; Ishibashi M; Takahashi Y; Kawakami T; Omura S
A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.
The Journal of antibiotics 1991;44(8):814-8.
1991: Tsuzuki K; Yan F S; Otoguro K; Omura S
Synthesis and nematocidal activities of jietacin A and its analogs.
The Journal of antibiotics 1991;44(7):774-84.
1991: Ishibashi M; Funayama S; Anraku Y; Komiyama K; Omura S
Novel antibiotics, furaquinocins C, D, E, F, G and H.
The Journal of antibiotics 1991;44(4):390-5.
1991: Tomoda H; Igarashi K; Cyong J C; Omura S
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation.
The Journal of biological chemistry 1991;266(7):4214-9.
1991: Nishida H; Tomoda H; Cao J; Araki S; Okuda S; Omura S
Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. III. Chemical modification of purpactin A.
The Journal of antibiotics 1991;44(2):152-9.
1991: Nishida H; Tomoda H; Cao J; Okuda S; Omura S
Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C.
The Journal of antibiotics 1991;44(2):144-51.
1991: Tomoda H; Nishida H; Masuma R; Cao J; Okuda S; Omura S
Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties.
The Journal of antibiotics 1991;44(2):136-43.
1990: Kumagai H; Nishida H; Imamura N; Tomoda H; Omura S; Bordner J
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp.
The Journal of antibiotics 1990;43(12):1553-8.
1990: Ikeda H; Omura S
Genetics of antibiotic-producing Streptomyces.
The Kitasato archives of experimental medicine 1990;63(4):1-13.
1990: Mori H; Funayama S; Sudo Y; Komiyama K; Omura S
A new antibiotic, 13-hydroxyglucopiericidin A. Isolation, structure elucidation and biological characteristics.
The Journal of antibiotics 1990;43(10):1329-31.
1990: Tomoda H; Omura S
New strategy for discovery of enzyme inhibitors: screening with intact mammalian cells or intact microorganisms having special functions.
The Journal of antibiotics 1990;43(10):1207-22.
1990: Kakinuma S; Ikeda H; Tanaka H; Omura S
Isolation of restriction-reduced mutants from Streptomyces.
Agricultural and biological chemistry 1990;54(10):2611-7.
1990: Satoh T; Inatomi N; Satoh H; Marui S; Itoh Z; Omura S
EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine.
The Journal of pharmacology and experimental therapeutics 1990;254(3):940-4.
1990: Oshino K; Kumagai H; Tomoda H; Omura S
Mechanism of action of atpenin B on Raji cells.
The Journal of antibiotics 1990;43(9):1064-8.
1990: Omura S; Tanaka Y; Kanaya I; Shinose M; Takahashi Y
Phthoxazolin, a specific inhibitor of cellulose biosynthesis, produced by a strain of Streptomyces sp.
The Journal of antibiotics 1990;43(8):1034-6.
1990: Kakinuma S; Ikeda H; Omura S; Hopwood D A
Biosynthesis of kalafungin in Streptomyces tanashiensis.
The Journal of antibiotics 1990;43(4):391-6.
1990: Kumagai H; Tomoda H; Omura S
Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells.
The Journal of antibiotics 1990;43(4):397-402.
1990: Komiyama K; Funayama S; Anraku Y; Ishibashi M; Takahashi Y; Omura S
Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.
The Journal of antibiotics 1990;43(3):247-52.
1990: Masuma R; Zhen D Z; Tanaka Y; Omura S
Site of regulation of nanaomycin biosynthesis by inorganic phosphate.
The Journal of antibiotics 1990;43(1):83-7.
1989: Funayama S; Ishibashi M; Anraku Y; Miyauchi M; Mori H; Komiyama K; Omura S
Novel cytocidal antibiotics, glucopiericidinols A1 and A2. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.
The Journal of antibiotics 1989;42(12):1734-40.
1989: Tanaka H; Kawakami T; Yang Z B; Komiyama K; Omura S
Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol.
The Journal of antibiotics 1989;42(11):1722-4.
1989: Sunazuka T; Tsuzuki K; Marui S; Toyoda H; Omura S; Inatomi N; Itoh Z
Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide.
Chemical & pharmaceutical bulletin 1989;37(10):2701-9.
1989: Tsuzuki K; Sunazuka T; Marui S; Toyoda H; Omura S; Inatomi N; Itoh Z
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal.
Chemical & pharmaceutical bulletin 1989;37(10):2687-700.
1989: Funayama S; Anraku Y; Mita A; Komiyama K; Omura S
Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp.
The Journal of antibiotics 1989;42(9):1350-5.
1989: Komiyama K; Funayama S; Anraku Y; Mita A; Takahashi Y; Omura S; Shimasaki H
Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.
The Journal of antibiotics 1989;42(9):1344-9.
1989: Nakagawa A; Miura S; Imai H; Imamura N; Omura S
Structure and biosynthesis of a new antifungal antibiotic, phthoramycin.
The Journal of antibiotics 1989;42(8):1324-7.
1989: Imai H; Nakagawa A; Omura S
Biosynthesis of the antibiotic okilactomycin.
The Journal of antibiotics 1989;42(8):1321-3.
1989: Omura S; Eda S; Funayama S; Komiyama K; Takahashi Y; Woodruff H B
Studies on a novel antitumor antibiotic, phenazinomycin: taxonomy, fermentation, isolation, and physicochemical and biological characteristics.
The Journal of antibiotics 1989;42(7):1037-42.
1989: Tsuzuki K; Yokozuka T; Murata M; Tanaka H; Omura S
Synthesis and biological activity of analogues of diazaquinomycin A, a new thymidylate synthase inhibitor.
The Journal of antibiotics 1989;42(5):727-37.
1989: Tanaka H; Kawakita K; Suzuki H; Spiri-Nakagawa P; Omura S
The mode of action of cervinomycin in Staphylococcus aureus.
The Journal of antibiotics 1989;42(3):431-9.
1989: Imamura N; Kuga H; Otoguro K; Tanaka H; Omura S
Structures of jietacines: unique alpha,beta-unsaturated azoxy antibiotics.
The Journal of antibiotics 1989;42(1):156-8.
1988: Omura S; Tanaka Y; Hisatome K; Miura S; Takahashi Y; Nakagawa A; Imai H; Woodruff H B
Phthoramycin, a new antibiotic active against a plant pathogen, Phytophthora sp.
The Journal of antibiotics 1988;41(12):1910-2.
1988: Omura S; Tomoda H; Kimura K; Zhen D Z; Kumagai H; Igarashi K; Imamura N; Takahashi Y; Tanaka Y; Iwai Y
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1988;41(12):1769-73.
1988: Funayama S; Anraku Y; Mita A; Yang Z B; Shibata K; Komiyama K; Umezawa I; Omura S
Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds.
The Journal of antibiotics 1988;41(9):1223-30.
1988: Otoguro K; Liu Z X; Fukuda K; Li Y; Iwai Y; Tanaka H; Omura S
Screening for new nematocidal substances of microbial origin by a new method using the pine wood nematode.
The Journal of antibiotics 1988;41(4):573-5.
1988: Otoguro K; Oiwa R; Iwai Y; Tanaka H; Omura S
Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A.
The Journal of antibiotics 1988;41(4):461-8.
1988: Ikeda H; Kotaki H; Tanaka H; Omura S
Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis.
Antimicrobial agents and chemotherapy 1988;32(2):282-4.
1988: Konda Y; Nakagawa A; Harigaya Y; Onda M; Masuma R; Omura S
Aurantinin B, a new antimicrobial antibiotic from bacterial origin.
The Journal of antibiotics 1988;41(2):268-70.
1988: Tanaka Y; Kimura K; Komagata Y; Tsuzuki K; Tomoda H; Omura S
Radioimmunoassay for erythromycin derivatives.
The Journal of antibiotics 1988;41(2):258-60.
1988: Otoguro K; Nakagawa A; Omura S
Setamycin, a 16-membered macrolide antibiotic. Identification and nematocidal activity.
The Journal of antibiotics 1988;41(2):250-2.
1988: Iwase H; Ishii I; Ishihara K; Tanaka Y; Omura S; Hotta K
Release of oligosaccharides possessing reducing-end N-acetylgalactosamine from mucus glycoprotein in Streptomyces sp. OH-11242 culture medium through action of endo-type glycosidase.
Biochemical and biophysical research communications 1988;151(1):422-8.
1988: Tomoda H; Kumagai H; Takahashi Y; Tanaka Y; Iwai Y; Omura S
F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties.
The Journal of antibiotics 1988;41(2):247-9.
1987: Ikeda H; Kotaki H; Omura S
Genetic studies of avermectin biosynthesis in Streptomyces avermitilis.
Journal of bacteriology 1987;169(12):5615-21.
1987: Masuma R; Okuyama K; Tanaka Y; Hirose R; Tomoda H; Iwai Y; Omura S
A new agar medium suitable for screening of anti-clostridium agents.
The Journal of antibiotics 1987;40(12):1773-5.
1987: Komiyama K; Hirokawa Y; Yamaguchi H; Funayama S; Masuda K; Anraku Y; Umezawa I; Omura S
Antitumor activity of trienomycin A on murine tumors.
The Journal of antibiotics 1987;40(12):1768-72.
1987: Tomoda H; Kumagai H; Tanaka H; Omura S
F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase.
Biochimica et biophysica acta 1987;922(3):351-6.
1987: Nakagawa A; Fujimoto T; Omura S; Walsh J C; Stotish R L; George B
Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery.
The Journal of antibiotics 1987;40(11):1627-35.
1987: Omura S; Nakagawa A; Fujimoto T; Saito K; Otoguro K; Walsh J C
Hygromycin A, an antitreponemal substance. I. Screening method and therapeutic effect for Treponema hyodysenteriae-caused infection in CF-1 mice.
The Journal of antibiotics 1987;40(11):1619-26.
1987: Omura S; Tsuzuki K; Sunazuka T; Marui S; Toyoda H; Inatomi N; Itoh Z
Macrolides with gastrointestinal motor stimulating activity.
Journal of medicinal chemistry 1987;30(11):1941-3.
1987: Tomoda H; Igarashi K; Tanaka Y; Omura S; Funabashi H; Okuda S
Biosynthetic preparation of labeled cerulenin with high specific radioactivity.
The Journal of antibiotics 1987;40(10):1457-60.
1987: Tomoda H; Igarashi K; Omura S
Inhibition of acyl-CoA synthetase by triacsins.
Biochimica et biophysica acta 1987;921(3):595-8.
1987: Omura S; Otoguro K; Imamura N; Kuga H; Takahashi Y; Masuma R; Tanaka Y; Tanaka H; Su X H; You E T
Jietacins A and B, new nematocidal antibiotics from a Streptomyces sp. Taxonomy, isolation, and physico-chemical and biological properties.
The Journal of antibiotics 1987;40(5):623-9.
1986: Omura S; Imamura N; Oiwa R; Kuga H; Iwata R; Masuma R; Iwai Y
Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
The Journal of antibiotics 1986;39(10):1407-12.
1981: Omura S; Iwai Y; Takahashi Y; Kojima K; Otoguro K; Oiwa R
Type of diaminopimelic acid different in aerial and vegetative mycelia of setamycin-producing actinomycete KM-6054.
The Journal of antibiotics 1981;34(12):1633-4.
1981: Omura S; Otoguro K; Nishikiori T; Oiwa R; Iwai Y
Setamycin, a new antibiotic.
The Journal of antibiotics 1981;34(10):1253-6.

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