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Pierluigi Onali

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Maria C Olianas; Simona Dedoni; Pierluigi Onali
Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex.
Maria C Olianas; Simona Dedoni; Pierluigi Onali
Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex.
Maria C Olianas; Simona Dedoni; Pierluigi Onali
The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors.

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All Publications

2013: Maria C Olianas; Simona Dedoni; Pierluigi Onali
Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex.
Neuro-Signals 2013;21(1-2):61-74.
2012: Maria C Olianas; Simona Dedoni; Pierluigi Onali
Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex.
Neurochemistry international 2012;61(8):1404-16.
2012: Maria C Olianas; Simona Dedoni; Pierluigi Onali
The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors.
British journal of pharmacology 2012;167(6):1329-41.
2012: Simona Dedoni; Angela Ingianni; Maria C Olianas; Pierluigi Onali
Type I interferons impair BDNF-induced cell signaling and neurotrophic activity in differentiated human SH-SY5Y neuroblastoma cells and mouse primary cortical neurons.
Journal of neurochemistry 2012;122(1):58-71.
2012: Maria C Olianas; Simona Dedoni; Alessandra Olianas; Pierluigi Onali
δ-Opioid receptors stimulate the metabolic sensor AMP-activated protein kinase through coincident signaling with G(q/11)-coupled receptors.
Molecular pharmacology 2012;81(2):154-65.
2011: Maria C Olianas; Simona Dedoni; Pierluigi Onali
Regulation of PI3K/Akt signaling by N-desmethylclozapine through activation of δ-opioid receptor.
European journal of pharmacology 2011;660(2-3):341-50.
2011: Maria C Olianas; Simona Dedoni; Pierluigi Onali
Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells.
Neuropharmacology 2011;60(7-8):1326-36.
2011: Maria C Olianas; Simona Dedoni; Pierluigi Onali
δ-Opioid receptors stimulate GLUT1-mediated glucose uptake through Src- and IGF-1 receptor-dependent activation of PI3-kinase signalling in CHO cells.
British journal of pharmacology 2011;163(3):624-37.
2010: Simona Dedoni; Maria C Olianas; Pierluigi Onali
Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway.
Journal of neurochemistry 2010;115(6):1421-33.
2010: Pierluigi Onali; Simona Dedoni; Maria C Olianas
Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes.
The Journal of pharmacology and experimental therapeutics 2010;332(1):255-65.
2009: Maria C Olianas; Simona Dedoni; Rossano Ambu; Pierluigi Onali
Agonist activity of N-desmethylclozapine at delta-opioid receptors of human frontal cortex.
European journal of pharmacology 2009;607(1-3):96-101.
2008: Maria C Olianas; Simona Dedoni; Marianna Boi; Pierluigi Onali
Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D(1) receptor signaling in rat nucleus accumbens and dorsal striatum.
Journal of neurochemistry 2008;107(2):544-56.
2007: Maria C Olianas; S Dedoni; Pierluigi Onali
Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons.
Neuroscience 2007;146(3):1289-301.
2007: Pierluigi Onali; Maria C Olianas
N-Desmethylclozapine, a major clozapine metabolite, acts as a selective and efficacious delta-opioid agonist at recombinant and native receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(4):773-85.
2006: Maria C Olianas; Paolo Solari; Luciana Garau; Anna Liscia; Roberto Crnjar; Pierluigi Onali
Stimulation of cyclic AMP formation and nerve electrical activity by octopamine in the terminal abdominal ganglion of the female gypsy moth Lymantria dispar.
Brain research 2006;1071(1):63-74.
2006: Maria C Olianas; Danilo Concas; Pierluigi Onali
Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors.
British journal of pharmacology 2006;147(4):360-70.
2005: Pierluigi Onali; Abdu Adem; Evert Karlsson; Maria C Olianas
The pharmacological action of MT-7.
Life sciences 2005;76(14):1547-52.
2005: Maria C Olianas; Rossano Ambu; Luciana Garau; Pierluigi Onali
Allosteric modulation of GABA(B) receptor function in human frontal cortex.
Neurochemistry international 2005;46(2):149-58.
2004: Pierluigi Onali; Maria C Olianas
G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb.
British journal of pharmacology 2004;143(5):638-48.
2004: Maria C Olianas; Abdu Adem; Evert Karlsson; Pierluigi Onali
Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.
European journal of pharmacology 2004;487(1-3):65-72.
2003: Pierluigi Onali; Francesca M Mascia; Maria C Olianas
Positive regulation of GABA(B) receptors dually coupled to cyclic AMP by the allosteric agent CGP7930.
European journal of pharmacology 2003;471(2):77-84.
2003: Maria C Olianas; Pierluigi Onali
Sodium ions and GTP decrease the potency of [Nphe1]N/OFQ(1-13)NH2 in blocking nociceptin/orphanin FQ receptors coupled to cyclic AMP in N1E-115 neuroblastoma cells and rat olfactory bulb.
Life sciences 2003;72(25):2905-14.
2002: Pierluigi Onali; Maria C Olianas
Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens.
European journal of pharmacology 2002;448(2-3):105-11.
2002: Maria C Olianas; Pierluigi Onali
Pharmacological properties of nociceptin/orphanin FQ-induced stimulation and inhibition of cyclic AMP formation in distinct layers of rat olfactory bulb.
British journal of pharmacology 2002;135(1):233-8.
2001: Pierluigi Onali; Maria C Olianas
Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.
Biochemical pharmacology 2001;62(2):183-90.
2001: Palmina Petruzzo; Antonello Cappai; Saturnino Spiga; Susanna Picciau; Giuliana Paola Serra; Liana Fattore; Pierluigi Onali; Giovanni Brotzu
Evidence of pituitary adenylate cyclase activating polypeptide (PACAP) in pancreatic islet cells by confocal microscopy.
Pancreas 2001;23(1):68-71.
2001: Pierluigi Onali; Angela Ingianni; Maria C Olianas
Dual coupling of opioid receptor-like (ORL1) receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb.
Journal of neurochemistry 2001;77(6):1520-30.
2000: Maria C Olianas; C Maullu; Abdu Adem; Ezra Mulugeta; Evert Karlsson; Pierluigi Onali
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
British journal of pharmacology 2000;131(3):447-52.
2000: Evert Karlsson; M Jolkkonen; Ezra Mulugeta; Pierluigi Onali; Abdu Adem
Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors.
Biochimie 2000;82(9-10):793-806.
2000: Maria C Olianas; Pierluigi Onali
Involvement of betagamma subunits of G(q/11) in muscarinic M(1) receptor potentiation of corticotropin-releasing hormone-stimulated adenylyl cyclase activity in rat frontal cortex.
Journal of neurochemistry 2000;75(1):233-9.
1999: Maria C Olianas; C Maullu; Angela Ingianni; Pierluigi Onali
[Phe1phi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as a partial agonist at ORL1 receptor endogenously expressed in mouse N1E-115 neuroblastoma cells.
Neuroreport 1999;10(5):1127-31.
1999: Maria C Olianas; Pierluigi Onali
Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb.
Biochemical pharmacology 1999;57(6):649-52.
1999: Maria C Olianas; C Maullu; Pierluigi Onali
Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;20(3):263-70.
1999: Maria C Olianas; Pierluigi Onali
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb.
British journal of pharmacology 1999;126(3):657-64.
1999: Maria C Olianas; Pierluigi Onali
PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP.
Life sciences 1999;65(21):2233-40.
1999: Maria C Olianas; Angela Ingianni; C Maullu; Abdu Adem; Evert Karlsson; Pierluigi Onali
Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors.
The Journal of pharmacology and experimental therapeutics 1999;288(1):164-70.
1998: Maria C Olianas; Abdu Adem; Evert Karlsson; Pierluigi Onali
Identification of rat brain muscarinic M4 receptors coupled to cyclic AMP using the selective antagonist muscarinic toxin 3.
European journal of pharmacology 1998;357(2-3):235-42.
1998: Pierluigi Onali; Maria C Olianas
Identification and characterization of muscarinic receptors potentiating the stimulation of adenylyl cyclase activity by corticotropin-releasing hormone in membranes of rat frontal cortex.
The Journal of pharmacology and experimental therapeutics 1998;286(2):753-9.
1998: Maria C Olianas; Angela Ingianni; Pierluigi Onali
Role of G protein betagamma subunits in muscarinic receptor-induced stimulation and inhibition of adenylyl cyclase activity in rat olfactory bulb.
Journal of neurochemistry 1998;70(6):2620-7.
1997: Maria C Olianas; C Maullu; Pierluigi Onali
Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor.
British journal of pharmacology 1997;122(3):401-8.
1997: Maria C Olianas; Angela Ingianni; Valeria Sogos; Pierluigi Onali
Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors and PACAP in human fetal retina.
Journal of neurochemistry 1997;69(3):1213-8.
1997: Maria C Olianas; Pierluigi Onali
Impairment of muscarinic stimulation of adenylyl cyclase by heparin in rat olfactory bulb.
Life sciences 1997;61(5):515-22.
1996: Maria C Olianas; Pierluigi Onali
Stimulation of guanosine 5'-O-(3-[35S] thiotriphosphate) binding by cholinergic muscarinic receptors in membranes of rat olfactory bulb.
Journal of neurochemistry 1996;67(6):2549-56.
1996: Maria C Olianas; Maria Grazia Ennas; Giorgio Lampis; Pierluigi Onali
Presence of pituitary adenylate cyclase-activating polypeptide receptors in Y-79 human retinoblastoma cells.
Journal of neurochemistry 1996;67(3):1293-300.
1996: Maria C Olianas; Pierluigi Onali
Antagonism of striatal muscarinic receptors inhibiting dopamine D1 receptor-stimulated adenylyl cyclase activity by cholinoceptor antagonist used to treat Parkinson's disease.
British journal of pharmacology 1996;118(4):827-8.
1996: Maria C Olianas; A Adem; E Karlsson; Pierluigi Onali
Rat striatal muscarinic receptors coupled to the inhibition of adenylyl cyclase activity: potent block by the selective m4 ligand muscarinic toxin 3 (MT3).
British journal of pharmacology 1996;118(2):283-8.
1996: Maria C Olianas; Pierluigi Onali
Characterization of the G protein involved in the muscarinic stimulation of adenylyl cyclase of rat olfactory bulb.
Molecular pharmacology 1996;49(1):22-9.
1995: Maria C Olianas; Pierluigi Onali
Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1560-7.
1995: Maria C Olianas; Pierluigi Onali
G protein-coupled corticotropin-releasing hormone receptors in rat retina.
Regulatory peptides 1995;56(1):61-70.
1995: Pierluigi Onali; Maria C Olianas
Bimodal regulation of cyclic AMP by muscarinic receptors. Involvement of multiple G proteins and different forms of adenylyl cyclase.
Life sciences 1995;56(11-12):973-80.
1995: Maria C Olianas; Giorgio Lampis; Pierluigi Onali
Human Y-79 retinoblastoma cells exhibit specific corticotropin-releasing hormone binding sites.
Journal of neurochemistry 1995;64(1):402-7.
1995: Maria C Olianas; Giorgio Lampis; Pierluigi Onali
Coupling of corticotropin-releasing hormone receptors to adenylyl cyclase in human Y-79 retinoblastoma cells.
Journal of neurochemistry 1995;64(1):394-401.
1994: Pierluigi Onali; A J Aasen; Maria C Olianas
Antagonism by (R)- and (S)-trihexyphenidyl of muscarinic stimulation of adenylyl cyclase in rat olfactory bulb and inhibition in striatum and heart.
British journal of pharmacology 1994;113(3):775-80.
1994: Maria C Olianas; Pierluigi Onali
Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb.
Journal of neurochemistry 1994;63(1):161-8.
1994: Pierluigi Onali; Maria C Olianas
PACAP is a potent and highly effective stimulator of adenylyl cyclase activity in the retinas of different mammalian species.
Brain research 1994;641(1):132-4.
1993: Maria C Olianas; Pierluigi Onali
Synergistic interaction of muscarinic and opioid receptors with GS-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb.
Journal of neurochemistry 1993;61(6):2183-90.
1993: Maria C Olianas; V Loi; M Lai; E Mosca; Pierluigi Onali
Corticotropin-releasing hormone stimulates adenylyl cyclase activity in the retinas of different animal species.
Regulatory peptides 1993;47(2):127-32.
1993: Maria C Olianas; Pierluigi Onali
Stimulation of phosphoinositide hydrolysis by muscarinic receptor activation in the rat olfactory bulb.
Biochemical pharmacology 1993;45(2):281-7.
1992: Maria C Olianas; Giorgio Lampis; Pierluigi Onali
Human Y-79 retinoblastoma cells express functional corticotropin-releasing hormone receptors.
Brain research 1992;593(2):304-6.
1992: Pierluigi Onali; Maria C Olianas
Is forskolin stimulation of rat striatal tyrosine hydroxylase dependent on adenylate cyclase activation?
Neuroscience letters 1992;145(2):161-4.
1992: Maria C Olianas; Pierluigi Onali
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb.
Molecular pharmacology 1992;42(1):109-15.
1992: Maria C Olianas; Pierluigi Onali
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Journal of neurochemistry 1992;58(5):1723-9.
1992: Pierluigi Onali; E Mosca; Maria C Olianas
Presynaptic dopamine autoreceptors and second messengers controlling tyrosine hydroxylase activity in rat brain.
Neurochemistry international 1992;20 Suppl():89S-93S.
1992: Pierluigi Onali; Maria C Olianas
B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity.
Journal of neural transmission. General section 1992;88(2):95-104.
1991: Maria C Olianas; Pierluigi Onali
Muscarinic stimulation of adenylate cyclase activity of rat olfactory bulb. I. Analysis of agonist sensitivity.
The Journal of pharmacology and experimental therapeutics 1991;259(2):673-9.
1991: Maria C Olianas; Pierluigi Onali
Muscarinic stimulation of adenylate cyclase activity of rat olfactory bulb. II. Characterization of the antagonist sensitivity and comparison with muscarinic inhibitions of the enzyme in striatum and heart.
The Journal of pharmacology and experimental therapeutics 1991;259(2):680-6.
1991: Pierluigi Onali; Maria C Olianas
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Molecular pharmacology 1991;39(4):436-41.
1990: Maria C Olianas; Pierluigi Onali
Alteration of the GTP-dependent inhibitory pathway of rat striatal adenylate cyclase by phorbol esters.
Neurochemical research 1990;15(11):1109-14.
1990: Pierluigi Onali; Maria C Olianas
CRF-like effects of sauvagine and urotensin I on synaptosomal tyrosine hydroxylase activity of mouse striatum.
Brain research 1990;526(2):181-5.
1990: Maria C Olianas; Pierluigi Onali
Ca2(+)-independent stimulation of adenylate cyclase activity by muscarinic receptors in rat olfactory bulb.
Journal of neurochemistry 1990;55(3):1083-6.
1990: Pierluigi Onali; Maria C Olianas
Positive coupling of cholinergic muscarinic receptors to adenylate cyclase activity in membranes of rat olfactory bulb.
Naunyn-Schmiedeberg's archives of pharmacology 1990;342(1):107-9.
1990: Maria C Olianas; Pierluigi Onali
Presence of corticotropin-releasing factor-stimulated adenylate cyclase activity in rat retina.
Journal of neurochemistry 1990;54(6):1967-71.
1990: Maria C Olianas; Pierluigi Onali
Activation of adenosine A1 receptor by N6-(R)-phenylisopropyladenosine (R-PIA) inhibits forskolin-stimulated tyrosine hydroxylase activity in rat striatal synaptosomes.
Life sciences 1990;46(8):591-8.
1989: Maria C Olianas; Pierluigi Onali
Stimulation of synaptosomal dopamine synthesis by corticotropin-releasing factor in rat striatum: role of Ca2+-dependent mechanisms.
European journal of pharmacology 1989;166(2):165-74.
1989: Pierluigi Onali; Maria C Olianas
Involvement of adenylate cyclase inhibition in dopamine autoreceptor regulation of tyrosine hydroxylase in rat nucleus accumbens.
Neuroscience letters 1989;102(1):91-6.
1988: Pierluigi Onali; Maria C Olianas; B Bunse
Evidence that adenosine A2 and dopamine autoreceptors antagonistically regulate tyrosine hydroxylase activity in rat striatal synaptosomes.
Brain research 1988;456(2):302-9.
1988: Maria C Olianas; Pierluigi Onali
Corticotropin-releasing factor activates tyrosine hydroxylase in rat and mouse striatal homogenates.
European journal of pharmacology 1988;150(3):389-92.
1985: Pierluigi Onali; G Mereu; Maria C Olianas; B Bunse; Z Rossetti; Gian Luigi Gessa
SCH 23390, a selective D1 dopamine receptor blocker, enhances the firing rate of nigral dopaminergic neurons but fails to activate striatal tyrosine hydroxylase.
Brain research 1985;340(1):1-7.