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Luke O'Neill

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Jefferies, Caroline
10
Bowie, Andrew
9
Fitzgerald, Katherine
8
Dunne, Aisling
8
Brint, Elizabeth
7
Doyle, Sarah
7
Brennan, Paul
6
Wietek, Claudia
5
McGettrick, Anne
5
Pålsson-McDermott, Eva
5
Golenbock, Douglas
5
Gray, Pearl
3
Hertzog, Paul
3
Brikos, Constantinos
3
Mansell, Ashley

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Publications

TOP 3
Novakovic Gordana
The immune system as an invisible, silent Grand Fugue. Interview by Luke O'Neill.
Kenny Elaine F; Talbot Suzanne; Gong Mei; Golenbock Douglas T; Bryant Clare E; O'Neill Luke A J
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Carpenter Susan; Carlson Thaddeus; Dellacasagrande Jerome; Garcia Amaya; Gibbons Sharon; Hertzog Paul; Lyons Anthony; Lin Lih-Ling; Lynch Marina; Monie Tom; Murphy Caroline; Seidl Katherine J; Wells Christine; Dunne Aisling; O'Neill Luke A J
TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.

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All Publications

2009: Novakovic Gordana
The immune system as an invisible, silent Grand Fugue. Interview by Luke O'Neill.
Nature immunology 2009;10(10):1043-5.
2009: Kenny Elaine F; Talbot Suzanne; Gong Mei; Golenbock Douglas T; Bryant Clare E; O'Neill Luke A J
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3642-51.
2009: Carpenter Susan; Carlson Thaddeus; Dellacasagrande Jerome; Garcia Amaya; Gibbons Sharon; Hertzog Paul; Lyons Anthony; Lin Lih-Ling; Lynch Marina; Monie Tom; Murphy Caroline; Seidl Katherine J; Wells Christine; Dunne Aisling; O'Neill Luke A J
TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3989-95.
2009: O'Neill Luke A J
DNA makes RNA makes innate immunity.
Cell 2009;138(3):428-30.
2009: Carpenter Susan; O'Neill Luke A J
Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.
The Biochemical journal 2009;422(1):1-10.
2009: O'Neill Luke A J; Bryant Clare E; Doyle Sarah L
Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer.
Pharmacological reviews 2009;61(2):177-97.
2009: Palsson-McDermott Eva M; Doyle Sarah L; McGettrick Anne F; Hardy Matthew; Husebye Harald; Banahan Kathy; Gong Mei; Golenbock Douglas; Espevik Terje; O'Neill Luke A J
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Nature immunology 2009;10(6):579-86.
2009: O'Neill Luke A J
Regulation of signaling by non-degradative ubiquitination.
The Journal of biological chemistry 2009;284(13):8209.
2009: Sharp Fiona A; Ruane Darren; Claass Benjamin; Creagh Emma; Harris James; Malyala Padma; Singh Manomohan; O'Hagan Derek T; Pétrilli Virginie; Tschopp Jurg; O'Neill Luke A J; Lavelle Ed C
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):870-5.
2009: McCoy Claire E; O'Neill Luke A J
Toll-like receptors: methods and protocols.Preface.
Methods in molecular biology (Clifton, N.J.) 2009;517():v-vi.
2008: O'Neill Luke A J
The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.
Immunological reviews 2008;226():10-8.
2008: Kenny Elaine F; O'Neill Luke A J
Signalling adaptors used by Toll-like receptors: an update.
Cytokine 2008;43(3):342-9.
2008: O'Neill Luke A J
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.
Immunity 2008;29(1):12-20.
2008: O'Neill Luke A J
Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?
Nature clinical practice. Rheumatology 2008;4(6):319-27.
2008: Costelloe Ceire; Watson Melanie; Murphy Aine; McQuillan Keith; Loscher Christine; Armstrong Michelle E; Garlanda Cecilia; Mantovani Alberto; O'Neill Luke A J; Mills Kingston H G; Lynch Marina A
IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.
Journal of neurochemistry 2008;105(5):1960-9.
2008: O'Neill Luke A J
Immunology. How frustration leads to inflammation.
Science (New York, N.Y.) 2008;320(5876):619-20.
2008: O'Neill Luke A J
'Fine tuning' TLR signaling.
Nature immunology 2008;9(5):459-61.
2008: McCoy Claire E; Carpenter Susan; Pålsson-McDermott Eva M; Gearing Linden J; O'Neill Luke A J
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation.
The Journal of biological chemistry 2008;283(21):14277-85.
2008: O'Neill Luke A J
Innate immunity: squelching anti-viral signalling with NLRX1.
Current biology : CB 2008;18(7):R302-4.
2008: O'Neill Luke A J
Bacteria fight back against Toll-like receptors.
Nature medicine 2008;14(4):370-2.
2008: Brikos Constantinos; O'Neill Luke A J
Signalling of toll-like receptors.
Handbook of experimental pharmacology 2008;(183):21-50.
2008: McCoy Claire E; O'Neill Luke A J
The role of toll-like receptors in macrophages.
Frontiers in bioscience : a journal and virtual library 2008;13():62-70.
2007: O'Neill Luke A J
TAMpering with toll-like receptor signaling.
Cell 2007;131(6):1039-41.
2007: Pålsson-McDermott E M; O'Neill L A J
Building an immune system from nine domains.
Biochemical Society transactions 2007;35(Pt 6):1437-44.
2007: Pålsson-McDermott E M; O'Neill L A J
The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases.
Irish journal of medical science 2007;176(4):253-60.
2007: Doyle Sarah L; Jefferies Caroline A; Feighery Con; O'Neill Luke A J
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
The Journal of biological chemistry 2007;282(51):36953-60.
2007: McGettrick Anne F; O'Neill Luke A J
Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.
British journal of haematology 2007;139(2):185-93.
2007: Becker Christine E; O'Neill Luke A J
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.
Seminars in immunopathology 2007;29(3):239-48.
2007: Brikos Constantinos; Wait Robin; Begum Shajna; O'Neill Luke A J; Saklatvala Jeremy
Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components.
Molecular & cellular proteomics : MCP 2007;6(9):1551-9.
2007: Watters Tanya M; Kenny Elaine F; O'Neill Luke A J
Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins.
Immunology and cell biology 2007;85(6):411-9.
2007: Carpenter Susan; O'Neill Luke A J
How important are Toll-like receptors for antimicrobial responses?
Cellular microbiology 2007;9(8):1891-901.
2007: Sheedy Frederick J; O'Neill Luke A J
The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.
Journal of leukocyte biology 2007;82(2):196-203.
2007: Wietek Claudia; O'Neill Luke A J
Diversity and regulation in the NF-kappaB system.
Trends in biochemical sciences 2007;32(7):311-9.
2007: Gubser Caroline; Goodbody Rory; Ecker Andrea; Brady Gareth; O'Neill Luke A J; Jacobs Nathalie; Smith Geoffrey L
Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence.
The Journal of general virology 2007;88(Pt 6):1667-76.
2007: O'Neill Luke A J; Bowie Andrew G
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Nature reviews. Immunology 2007;7(5):353-64.
2007: Miggin Sinead M; Pålsson-McDermott Eva; Dunne Aisling; Jefferies Caroline; Pinteaux Emmanuel; Banahan Kathy; Murphy Caroline; Moynagh Paul; Yamamoto Masahiro; Akira Shizuo; Rothwell Nancy; Golenbock Douglas; Fitzgerald Katherine A; O'Neill Luke A J
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: Serhan Charles N; Brain Sue D; Buckley Christopher D; Gilroy Derek W; Haslett Christopher; O'Neill Luke A J; Perretti Mauro; Rossi Adriano G; Wallace John L
Resolution of inflammation: state of the art, definitions and terms.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):325-32.
2007: Núñez Miguel Ricardo; Wong Joyce; Westoll Julian F; Brooks Heather J; O'Neill Luke A J; Gay Nicholas J; Bryant Clare E; Monie Tom P
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.
PloS one 2007;2(8):e788.
2006: Wietek Claudia; Cleaver Catherine S; Ludbrook Valerie; Wilde Jonathan; White Julia; Bell David J; Lee Michael; Dickson Marion; Ray Keith P; O'Neill Luke A J
IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65.
The Journal of biological chemistry 2006;281(46):34973-81.
2006: O'Neill Luke A J
DisSARMing Toll-like receptor signaling.
Nature immunology 2006;7(10):1023-5.
2006: Doyle Sarah L; O'Neill Luke A J
Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity.
Biochemical pharmacology 2006;72(9):1102-13.
2006: Creagh Emma M; O'Neill Luke A J
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity.
Trends in immunology 2006;27(8):352-7.
2006: Miggin Sinead M; O'Neill Luke A J
New insights into the regulation of TLR signaling.
Journal of leukocyte biology 2006;80(2):220-6.
2006: O'Neill Luke A J
Targeting signal transduction as a strategy to treat inflammatory diseases.
Nature reviews. Drug discovery 2006;5(7):549-63.
2006: McGettrick Anne F; Brint Elizabeth K; Palsson-McDermott Eva M; Rowe Daniel C; Golenbock Douglas T; Gay Nicholas J; Fitzgerald Katherine A; O'Neill Luke A J
Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9196-201.
2006: Rowe Daniel C; McGettrick Anne F; Latz Eicke; Monks Brian G; Gay Nicholas J; Yamamoto Masahiro; Akira Shizuo; O'Neill Luke A; Fitzgerald Katherine A; Golenbock Douglas T
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6299-304.
2006: Gray Pearl; Dunne Aisling; Brikos Constantinos; Jefferies Caroline A; Doyle Sarah L; O'Neill Luke A J
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
The Journal of biological chemistry 2006;281(15):10489-95.
2006: Mansell Ashley; Smith Rosealee; Doyle Sarah L; Gray Pearl; Fenner Jennifer E; Crack Peter J; Nicholson Sandra E; Hilton Douglas J; O'Neill Luke A J; Hertzog Paul J
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Nature immunology 2006;7(2):148-55.
2006: O'Neill Luke A J
How Toll-like receptors signal: what we know and what we don't know.
Current opinion in immunology 2006;18(1):3-9.
2005: O'Neill Luke A J
TLRs play good cop, bad cop in the lung.
Nature medicine 2005;11(11):1161-2.
2005: O'Toole Dermot; Abdel-Latif Mohamed M M; Long Aideen; Windle Henry J; Murphy Anne M; Bowie Andrew; O'Neill Luke A J; Weir Donald G; Kelleher Dermot
Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?
Journal of cellular biochemistry 2005;96(3):589-98.
2005: Brady Gareth; Boggan Louise; Bowie Andrew; O'Neill Luke A J
Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.
The Journal of biological chemistry 2005;280(35):30723-34.
2005: Liew Foo Y; Xu Damo; Brint Elizabeth K; O'Neill Luke A J
Negative regulation of toll-like receptor-mediated immune responses.
Nature reviews. Immunology 2005;5(6):446-58.
2005: Dunne Aisling; O'Neill Luke A J
Adaptor usage and Toll-like receptor signaling specificity.
FEBS letters 2005;579(15):3330-5.
2005: Doyle Sarah L; Jefferies Caroline A; O'Neill Luke A
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide.
The Journal of biological chemistry 2005;280(25):23496-501.
2005: O'Neill Luke A J
Immunity's early-warning system.
Scientific American 2005;292(1):24-31.
2004: O'Neill Luke A J
TLRs: Professor Mechnikov, sit on your hat.
Trends in immunology 2004;25(12):687-93.
2004: Pålsson-McDermott Eva M; O'Neill Luke A J
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.
Immunology 2004;113(2):153-62.
2004: Kiss-Toth Endre; Bagstaff Stephanie M; Sung Hye Y; Jozsa Veronika; Dempsey Clare; Caunt Jim C; Oxley Kevin M; Wyllie David H; Polgar Timea; Harte Mary; O'neill Luke A J; Qwarnstrom Eva E; Dower Steven K
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
The Journal of biological chemistry 2004;279(41):42703-8.
2004: Mansell Ashley; Brint Elizabeth; Gould Jodee A; O'Neill Luke A; Hertzog Paul J
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.
The Journal of biological chemistry 2004;279(36):37227-30.
2004: O'Neill Luke A J
How NOD-ing off leads to Crohn disease.
Nature immunology 2004;5(8):776-8.
2004: McGettrick Anne F; O'Neill Luke A J
The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction.
Molecular immunology 2004;41(6-7):577-82.
2004: Khan Javed A; Brint Elizabeth K; O'Neill Luke A J; Tong Liang
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.
The Journal of biological chemistry 2004;279(30):31664-70.
2004: Hardy Matthew P; O'Neill Luke A J
The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory.
The Journal of biological chemistry 2004;279(26):27699-708.
2004: Hardy Matthew P; McGGettrick Anne F; O'Neill Luke A J
Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene.
The Biochemical journal 2004;380(Pt 1):83-93.
2004: Brint Elizabeth K; Xu Damo; Liu Haiying; Dunne Aisling; McKenzie Andrew N J; O'Neill Luke A J; Liew Foo Y
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.
Nature immunology 2004;5(4):373-9.
2004: Jefferies Caroline A; O'Neill Luke A J
Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?
Immunology letters 2004;92(1-2):15-22.
2004: O'Neill Luke A J
Immunology. After the toll rush.
Science (New York, N.Y.) 2004;303(5663):1481-2.
2003: Wietek Claudia; Miggin Sinead M; Jefferies Caroline A; O'Neill Luke A J
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.
The Journal of biological chemistry 2003;278(51):50923-31.
2003: Hertzog Paul J; O'Neill Luke A; Hamilton John A
The interferon in TLR signaling: more than just antiviral.
Trends in immunology 2003;24(10):534-9.
2003: Dunne Aisling; Ejdeback Mikael; Ludidi Phumzile L; O'Neill Luke A J; Gay Nicholas J
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.
The Journal of biological chemistry 2003;278(42):41443-51.
2003: Dunn Eleanor F; Gay Nicholas J; Bristow Adrian F; Gearing David P; O'Neill Luke A J; Pei Xue Yuan
High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.
Biochemistry 2003;42(37):10938-44.
2003: O'Neill Luke A J
SIGIRR puts the brakes on Toll-like receptors.
Nature immunology 2003;4(9):823-4.
2003: O'Neill Luke A J
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.
Current opinion in pharmacology 2003;3(4):396-403.
2003: Ward Stephen G; O'Neill Luke A J
Spotlight on new anti-inflammatory drug targets in the immune system.
Current opinion in pharmacology 2003;3(4):391-5.
2003: Jefferies Caroline A; Doyle Sarah; Brunner Cornelia; Dunne Aisling; Brint Elizabeth; Wietek Claudia; Walch Eva; Wirth Thomas; O'Neill Luke A J
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
The Journal of biological chemistry 2003;278(28):26258-64.
2003: O'Neill Luke A J; Fitzgerald Katherine A; Bowie Andrew G
The Toll-IL-1 receptor adaptor family grows to five members.
Trends in immunology 2003;24(6):286-90.
2003: O'Neill L A J
The role of MyD88-like adapters in Toll-like receptor signal transduction.
Biochemical Society transactions 2003;31(Pt 3):643-7.
2003: O'Neill Luke A J; Brown Zarin; Ward Stephen G
Toll-like receptors in the spotlight.
Nature immunology 2003;4(4):299.
2003: Dunne Aisling; O'Neill Luke A J
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.
Science's STKE : signal transduction knowledge environment 2003;2003(171):re3.
2003: Harte Mary T; Haga Ismar R; Maloney Geraldine; Gray Pearl; Reading Patrick C; Bartlett Nathan W; Smith Geoffrey L; Bowie Andrew; O'Neill Luke A J
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense.
The Journal of experimental medicine 2003;197(3):343-51.
2003: O'Neill Luke A J; Dunne Aisling; Edjeback Michael; Gray Pearl; Jefferies Caroline; Wietek Claudia
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors.
Journal of endotoxin research 2003;9(1):55-9.
2002: Brint Elizabeth K; Fitzgerald Katherine A; Smith Philip; Coyle Anthony J; Gutierrez-Ramos Jose-Carlos; Fallon Padraic G; O'Neill Luke A J
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
The Journal of biological chemistry 2002;277(51):49205-11.
2002: O'Neill Luke A J
Wanted: a molecular basis for specificity in toll-like receptor signal transduction.
Molecular cell 2002;10(5):969-71.
2002: Corrigall Val; O'Neill Luke A J
Using immunotherapy to treat rheumatic diseases.
Trends in immunology 2002;23(8):383-4.
2002: Wietek Claudia; O'Neill Luke A
IRAK-4: a new drug target in inflammation, sepsis, and autoimmunity.
Molecular interventions 2002;2(4):212-5.
2002: O'Neill Luke A J
Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?
Trends in immunology 2002;23(6):296-300.
2002: O'Neill Luke A J
Is there a novel brain interleukin 1 receptor that signals ischaemic brain damage?
Trends in pharmacological sciences 2002;23(3):109-10.
2002: McDermott Eva Pålsson; O'Neill Luke A J
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.
The Journal of biological chemistry 2002;277(10):7808-15.
2002: O'Neill L A J
Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily.
Current topics in microbiology and immunology 2002;270():47-61.
2001: Mansell A; Reinicke A; Worrall D M; O'Neill L A
The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4.
FEBS letters 2001;508(3):313-7.
2001: Mansell A; Khelef N; Cossart P; O'Neill L A
Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.
The Journal of biological chemistry 2001;276(47):43597-603.
2001: Fitzgerald K A; Palsson-McDermott E M; Bowie A G; Jefferies C A; Mansell A S; Brady G; Brint E; Dunne A; Gray P; Harte M T; McMurray D; Smith D E; Sims J E; Bird T A; O'Neill L A
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Nature 2001;413(6851):78-83.
2001: Jefferies C; Bowie A; Brady G; Cooke E L; Li X; O'Neill L A
Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1.
Molecular and cellular biology 2001;21(14):4544-52.
2000: Bowie A G; O'Neill L A
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7180-8.
2000: O'Neill L A
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.
Science's STKE : signal transduction knowledge environment 2000;2000(44):re1.
2000: Boland M P; Fitzgerald K A; O'Neill L A
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.
The Journal of biological chemistry 2000;275(33):25231-8.
2000: Bowie A; Kiss-Toth E; Symons J A; Smith G L; Dower S K; O'Neill L A
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10162-7.
2000: Fitzgerald K A; O'Neill L A
The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence.
Microbes and infection / Institut Pasteur 2000;2(8):933-43.
2000: O'Neill L A; Dinarello C A
The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense.
Immunology today 2000;21(5):206-9.
2000: Mansell A; Braun L; Cossart P; O'Neill L A
A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages.
Cellular microbiology 2000;2(2):127-36.
2000: Fitzgerald K A; Bowie A G; Skeffington B S; O'Neill L A
Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2053-63.
2000: Jefferies C A; O'Neill L A
Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression.
The Journal of biological chemistry 2000;275(5):3114-20.
2000: Bowie A; O'Neill L A
Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.
Biochemical pharmacology 2000;59(1):13-23.
1999: Matthews J S; O'Neill L A
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.
Cytokine 1999;11(9):643-55.
1998: Boland M P; O'Neill L A
Ceramide activates NFkappaB by inducing the processing of p105.
The Journal of biological chemistry 1998;273(25):15494-500.
1998: Brennan P; O'Neill L A
Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers.
Biochemical pharmacology 1998;55(7):965-73.
1997: O'Neill L A; Matthews J S; Pålsson E; Jeffries C; Brennan P; Cantrell D A
Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase.
Biochemical Society transactions 1997;25(4):S578.
1997: Bowie A G; Moynagh P N; O'Neill L A
Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells.
The Journal of biological chemistry 1997;272(41):25941-50.
1997: Mahon T M; Matthews J S; O'Neill L A
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
The Biochemical journal 1997;325 ( Pt 1)():39-45.
1997: Boland M P; Foster S J; O'Neill L A
Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells.
The Journal of biological chemistry 1997;272(20):12952-60.
1997: Bowie A; O'Neill L A
Vitamin C inhibits NF kappa B activation in endothelial cells.
Biochemical Society transactions 1997;25(1):131S.
1997: Bowie A; O'Neill L A
Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells.
Biochemical Society transactions 1997;25(1):125S.
1997: O'Neill L A
Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture.
Biochemical Society transactions 1997;25(1):295-302.
1996: Brennan P; O'Neill L A
2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF kappa B by PDTC.
The Biochemical journal 1996;320 ( Pt 3)():975-81.
1996: Dunican D J; Griffiths R; Williams D C; O'Neill L A
Endothelin-1 increases arachidonic acid release in C6 glioma cells through a potassium-modulated influx of calcium.
Journal of neurochemistry 1996;67(2):830-7.
1996: Mahon T M; O'Neill L A
Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells.
Biochemical Society transactions 1996;24(1):81S.
1996: Brennan P; O'Neill L A
Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide.
Biochemical Society transactions 1996;24(1):3S.
1996: O'Neill L A
Interleukin I receptors and signal transduction.
Biochemical Society transactions 1996;24(1):207-11.
1996: Bowie A; Moynagh P N; O'Neill L A
Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells.
Biochemical Society transactions 1996;24(1):2S.
1996: Boland M P; Foster S J; O'Neill L A
Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event.
Biochemical Society transactions 1996;24(1):1S.
1995: Mahon T M; O'Neill L A
Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit.
The Journal of biological chemistry 1995;270(48):28557-64.
1995: Dunican D J; Griffiths R; O'Neill L A; Williams D C
Depolarising levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells.
Biochemical Society transactions 1995;23(2):285S.
1995: O'Neill L A
Towards an understanding of the signal transduction pathways for interleukin 1.
Biochimica et biophysica acta 1995;1266(1):31-44.
1995: Bowie A; Moynagh P N; O'Neill L A
The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1.
Biochemical Society transactions 1995;23(1):109S.
1995: Mahon T M; O'Neill L A
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A.
Biochemical Society transactions 1995;23(1):111S.
1995: Brennan P; O'Neill L A
Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals.
Biochimica et biophysica acta 1995;1260(2):167-75.
1994: Moynagh P N; Williams D C; O'Neill L A
Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2681-90.
1993: Brennan P; Bowie A; O'Neill L A
The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.
Biochemical Society transactions 1993;21(4):390S.
1993: Mahon T M; Brennan P; O'Neill L A
Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells.
Biochemical Society transactions 1993;21(4):389S.
1993: Moynagh P N; O'Neill L A; Williams D C
Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells.
Biochemical pharmacology 1993;46(5):821-7.
1993: Moynagh P N; Williams D C; O'Neill L A
Interleukin-1 activates transcription factor NF kappa B in glial cells.
The Biochemical journal 1993;294 ( Pt 2)():343-7.
1992: O'Neill L A
How does interleukin-1 activate cells?
Kidney international 1992;41(3):546-9.

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