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Paul O'Neill

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Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
Gemma L Nixon; Paul M O'Neill; Alison E Shone; Stephen A Ward; Nicholas Fisher; David Lalloo; Darren M Moss; Giancarlo A Biagini
Antimalarial pharmacology and therapeutics of atovaquone.
Ashley J Warman; Neil G Berry; Nicholas E Fisher; Darren M Moss; Paul M O'Neill; Teresa S Rito; Stephen A Ward; Giancarlo A Biagini
Antitubercular pharmacodynamics of phenothiazines.

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2013: Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
ChemMedChem 2013;8(5):709-18.
2013: Gemma L Nixon; Paul M O'Neill; Alison E Shone; Stephen A Ward; Nicholas Fisher; David Lalloo; Darren M Moss; Giancarlo A Biagini
Antimalarial pharmacology and therapeutics of atovaquone.
The Journal of antimicrobial chemotherapy 2013;68(5):977-85.
2013: Ashley J Warman; Neil G Berry; Nicholas E Fisher; Darren M Moss; Paul M O'Neill; Teresa S Rito; Stephen A Ward; Giancarlo A Biagini
Antitubercular pharmacodynamics of phenothiazines.
The Journal of antimicrobial chemotherapy 2013;68(4):869-80.
2012: Raman Sharma; Joanne Shearer; Alison E Shone; Paul Stocks; Stephen A Ward; Ashley J Warman; Richard K Amewu; Giancarlo A Biagini; James Chadwick; David Cronk; Nicholas E Fisher; Peter Gibbons; Ian Gowers; Alasdair Hill; David W Hong; Alexandre S Lawrenson; Suet Leung; Alison Mbekeani; Gemma L Nixon; Paul M O'Neill; Serge P Parel; Chandrakala Pidathala; Neil G Berry
Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
Journal of medicinal chemistry 2012;55(7):3144-54.
2012: Nicholas Fisher; David J Johnson; Alexandre S Lawrenson; Paul M O'Neill; Hilary Ranson; Stephen A Ward; Ashley J Warman; Roslaini Abd Majid; Mohammed Al-Helal; Thomas Antoine; Giancarlo A Biagini
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
The Journal of biological chemistry 2012;287(13):9731-41.
2012: Suet C Leung; Alison Mbekeani; Gemma L Nixon; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Bénédicte Pacorel; Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Paul M O'Neill
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1844-57.
2012: Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Suet C Leung; Alison Mbekeani; Gemma L Nixon; Bénédicte Pacorel; Paul M O'Neill
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1831-43.
2012: Ian M Copple; Maria L S Cristiano; Gail Donegan; James Firman; Bram Herpers; Amy E Mercer; Paul M O'Neill; Andreia D Bringela; James Chadwick; Bob van de Water; Stephen A Ward; Michael Hl Wong; B Kevin Park
Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.
Molecular medicine (Cambridge, Mass.) 2012;18():1045-55.
2011: Olivier Berger; Giancarlo A Biagini; Patrick G Bray; Archana Kaniti; Christophe Tran van Ba; Henri Vial; Stephen A Ward; Paul M O'Neill
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.
ChemMedChem 2011;6(11):2094-108.
2011: Emma-Claire Elliott; James L Maggs; Paul M O'Neill; B Kevin Park; Sophie L Regan; John Bacsa; Elizabeth R Bowkett; Andrew V Stachulski
Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.
Organic letters 2011;13(20):5592-5.
2011: Fatima Bousejra-El Garah; James Chadwick; James L Maggs; Sant Muangnoicharoen; B Kevin Park; Jean-Luc Stigliani; Stephen A Ward; Michael He-Long Wong; Richard K Amewu; Paul M O'Neill
Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
Journal of medicinal chemistry 2011;54(19):6443-55.
2011: James Chadwick; Fatima Bousejra-El Garah; Francesc Marti; Richard K Amewu; Neil G Berry; Reto Brun; Hollie Burrell-Saward; Silvia Parapini; Matthias Rottmann; Raman Sharma; Paul A Stocks; Donatella Taramelli; Stephen A Ward; Sergio Wittlin; Paul M O'Neill
Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
ChemMedChem 2011;6(8):1357-61.
2011: Bradley J Stevenson; Michael J Sutcliffe; Patricia Pignatelli; Andrew Steven; Jaclyn Bibby; Janet Hemingway; Lu-Yun Lian; Sant Muangnoicharoen; Pie Müller; Dimitra Nikou; Paul M O'Neill; Mark J I Paine
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.
Insect biochemistry and molecular biology 2011;41(7):492-502.
2011: Amy Mercer; Ian M Copple; James L Maggs; Paul M O'Neill; B Kevin Park
The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.
The Journal of biological chemistry 2011;286(2):987-96.
2010: Peter Gibbons; Edite Verissimo; Nuna C Araujo; Victoria Barton; Gemma L Nixon; Richard K Amewu; James Chadwick; Paul A Stocks; Giancarlo A Biagini; Abhishek Srivastava; Philip J Rosenthal; Jiri Gut; Rita C Guedes; Rui Moreira; Raman Sharma; Neil Berry; M Lurdes S Cristiano; Alison E Shone; Stephen A Ward; Paul M O'Neill
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Journal of medicinal chemistry 2010;53(22):8202-6.
2010: Paul M O'Neill; Richard K Amewu; Gemma L Nixon; Fatima Bousejra ElGarah; Mathirut Mungthin; James Chadwick; Alison E Shone; Livia Vivas; Hollie Lander; Victoria Barton; Sant Muangnoicharoen; Patrick G Bray; Jill Davies; B Kevin Park; Sergio Wittlin; Reto Brun; Michael Preschel; Kesheng Zhang; Stephen A Ward
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
Angewandte Chemie (International ed. in English) 2010;49(33):5693-7.
2010: Victoria Barton; Nicholas Fisher; Giancarlo A Biagini; Stephen A Ward; Paul M O'Neill
Inhibiting Plasmodium cytochrome bc1: a complex issue.
Current opinion in chemical biology 2010;14(4):440-6.
2010: Victoria Barton; Steven A Ward; James Chadwick; Alasdair Hill; Paul M O'Neill
Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics.
Journal of medicinal chemistry 2010;53(11):4555-9.
2010: Richard Amewu; Peter Gibbons; Amira Mukhtar; Andrew V Stachulski; Stephen A Ward; Charlotte Hall; Karen Rimmer; Jill Davies; Livia Vivas; John Bacsa; Amy Mercer; Gemma Nixon; Paul A Stocks; Paul M O'Neill
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Organic & biomolecular chemistry 2010;8(9):2068-77.
2010: James Chadwick; Michael Jones; Amy Mercer; Paul A Stocks; Stephen A Ward; B Kevin Park; Paul M O'Neill
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.
Bioorganic & medicinal chemistry 2010;18(7):2586-97.
2010: Paul M O'Neill; Victoria E Barton; Stephen A Ward
The molecular mechanism of action of artemisinin--the debate continues.
Molecules (Basel, Switzerland) 2010;15(3):1705-21.
2010: Bénédicte Pacorel; Suet C Leung; Andrew V Stachulski; Jill Davies; Livia Vivas; Hollie Lander; Stephen A Ward; Marcel Kaiser; Reto Brun; Paul M O'Neill
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
Journal of medicinal chemistry 2010;53(2):633-40.
2010: J Luis Castrejon; Sidonie N Lavergne; Ayman El-Sheikh; John Farrell; James L Maggs; Sunil Sabbani; Paul M O'Neill; B Kevin Park; Dean J Naisbitt
Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.
Chemical research in toxicology 2010;23(1):184-92.
2009: Paul M O'Neill; Alison E Shone; Deborah Stanford; Gemma Nixon; Eghbaleh Asadollahy; B Kevin Park; James L Maggs; Phil Roberts; Paul A Stocks; Giancarlo Biagini; Patrick G Bray; Jill Davies; Neil Berry; Charlotte Hall; Karen Rimmer; Peter A Winstanley; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Stephanie L Gresham; Richard A Brigandi; Federico M Gomez-de-Las-Heras; Domingo V Gargallo; Silvia Parapini; Livia Vivas; Hollie Lander; Donatella Taramelli; Stephen A Ward
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Journal of medicinal chemistry 2009;52(7):1828-44.
2009: Michael Jones; Amy Mercer; Paul A Stocks; Louise J I La Pensée; Richard Cosstick; B Kevin Park; Miriam E Kennedy; Ivo Piantanida; Stephen A Ward; Jill Davies; Patrick G Bray; Sarah L Rawe; Jonathan Baird; Tafadzwa Charidza; Omar Janneh; Paul M O'Neill
Antitumour and antimalarial activity of artemisinin-acridine hybrids.
Bioorganic & medicinal chemistry letters 2009;19(7):2033-7.
2009: Paul M O'Neill; B Kevin Park; Alison E Shone; James L Maggs; Phillip Roberts; Paul A Stocks; Giancarlo A Biagini; Patrick G Bray; Peter Gibbons; Neil Berry; Peter A Winstanley; Amira Mukhtar; Richard Bonar-Law; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Timothy K Hart; Stephanie L Gresham; Ron M Lawrence; Richard A Brigandi; Federico M Gomez-delas-Heras; Domingo V Gargallo; Stephen A Ward
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Journal of medicinal chemistry 2009;52(5):1408-15.
2009: James Chadwick; Amy Mercer; B Kevin Park; Richard Cosstick; Paul M O'Neill
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
Bioorganic & medicinal chemistry 2009;17(3):1325-38.
2008: Sunil Sabbani; Paul A Stocks; Gemma L Ellis; Jill Davies; Erik Hedenstrom; Stephen A Ward; Paul M O'Neill
Piperidine dispiro-1,2,4-trioxane analogues.
Bioorganic & medicinal chemistry letters 2008;18(21):5804-8.
2008: Giancarlo A Biagini; Nicholas Fisher; Neil Berry; Paul A Stocks; Brigitte Meunier; Dominic P Williams; Richard Bonar-Law; Patrick G Bray; Andrew Owen; Paul M O'Neill; Stephen A Ward
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.
Molecular pharmacology 2008;73(5):1347-55.
2008: Gemma L Ellis; Richard Amewu; Sunil Sabbani; Paul A Stocks; Alison Shone; Deborah Stanford; Peter Gibbons; Jill Davies; Livia Vivas; Sarah Charnaud; Emily Bongard; Charlotte Hall; Karen Rimmer; Sonia Lozanom; María Jesús; Domingo Gargallo; Stephen A Ward; Paul M O'Neill
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Journal of medicinal chemistry 2008;51(7):2170-7.
2008: Gemma L Ellis; Richard Amewu; Charlotte Hall; Karen Rimmer; Stephen A Ward; Paul M O'Neill
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.
Bioorganic & medicinal chemistry letters 2008;18(5):1720-4.
2007: Amy Mercer; James L Maggs; Xiao-Ming Sun; Gerald M Cohen; James Chadwick; Paul M O'Neill; B Kevin Park
Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds.
The Journal of biological chemistry 2007;282(13):9372-82.
2007: Paul A Stocks; Patrick G Bray; Victoria E Barton; Mohammed Al-Helal; Michael Jones; Nuna C Araujo; Peter Gibbons; Stephen A Ward; Ruth H Hughes; Giancarlo A Biagini; Jill Davies; Richard Amewu; Amy Mercer; Gemma Ellis; Paul M O'Neill
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Angewandte Chemie (International ed. in English) 2007;46(33):6278-83.
2006: Richard Amewu; Andrew V Stachulski; Stephen A Ward; Neil G Berry; Patrick G Bray; Jill Davies; Gael Labat; Livia Vivas; Paul M O'Neill
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.
Organic & biomolecular chemistry 2006;4(24):4431-6.
2006: Richard Amewu; Andrew V Stachulski; Neil G Berry; Stephen A Ward; Jill Davies; Gael Labat; Jean-François Rossignol; Paul M O'Neill
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.
Bioorganic & medicinal chemistry letters 2006;16(23):6124-30.
2006: Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; Fidock David; david charles warhurst; Stephen A Ward
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Molecular microbiology 2006;62(1):238-51.
2006: Paul M O'Neill; Edite Verissimo; Stephen A Ward; Jill Davies; Edward E Korshin; Nuna C Araujo; Matthew D Pugh; M Lurdes S Cristiano; Paul A Stocks; Mario D Bachi
Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.
Bioorganic & medicinal chemistry letters 2006;16(11):2991-5.
2006: Giancarlo A Biagini; Parnpen Viriyavejakul; Paul M O'Neill; Patrick G Bray; Stephen A Ward
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
Antimicrobial agents and chemotherapy 2006;50(5):1841-51.
2006: Paul M O'Neill; Stephen A Ward; Neil G Berry; J Prince Jeyadevan; Giancarlo A Biagini; Egbaleh Asadollaly; B Kevin Park; Patrick G Bray
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.
Current topics in medicinal chemistry 2006;6(5):479-507.
2005: Paul M O'Neill; Sarah L Rawe; Kristina Borstnik; Alison Miller; Stephen A Ward; Patrick G Bray; Jill Davies; Chang Ho Oh; Gary H Posner
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.
Chembiochem : a European journal of chemical biology 2005;6(11):2048-54.
2005: Giancarlo A Biagini; Paul M O'Neill; Patrick G Bray; Stephen A Ward
Current drug development portfolio for antimalarial therapies.
Current opinion in pharmacology 2005;5(5):473-8.
2005: Paul M O'Neill
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.
Expert opinion on investigational drugs 2005;14(9):1117-28.
2005: Patrick G Bray; Stephen A Ward; Paul M O'Neill
Quinolines and artemisinin: chemistry, biology and history.
Current topics in microbiology and immunology 2005;295():3-38.
2004: Giancarlo A Biagini; Erica M Pasini; Ruth Hughes; Harry P De Koning; Henri VIAL; Paul M O'Neill; Stephen A Ward; Patrick G Bray
Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.
Blood 2004;104(10):3372-7.
2004: Paul M O'Neill; Amira Mukhtar; Stephen A Ward; Jamie F Bickley; Jill Davies; Mario D Bachi; Paul A Stocks
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
Organic letters 2004;6(18):3035-8.
2004: Paul M O'Neill; Paul A Stocks; Matthew D Pugh; Nuna C Araujo; Edward E Korshin; Jamie F Bickley; Stephen A Ward; Patrick G Bray; Erica Pasini; Jill Davies; Edite Verissimo; Mario D Bachi
Design and synthesis of endoperoxide antimalarial prodrug models.
Angewandte Chemie (International ed. in English) 2004;43(32):4193-7.
2004: Paul M O'Neill; Gary H Posner
A medicinal chemistry perspective on artemisinin and related endoperoxides.
Journal of medicinal chemistry 2004;47(12):2945-64.
2004: James L Maggs; Laurence P D Bishop; Kevin Batty; Charlotte C Dodd; Kenneth F Ilett; Paul M O'Neill; Geoffrey Edwards; B Kevin Park
Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.
Chemico-biological interactions 2004;147(2):173-84.
2004: J Prince Jeyadevan; Patrick G Bray; James Chadwick; Amy Mercer; Aoife Byrne; Stephen A Ward; B Kevin Park; Dominic P Williams; Richard Cosstick; Jill Davies; Adrian P Higson; Ed Irving; Gary H Posner; Paul M O'Neill
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.
Journal of medicinal chemistry 2004;47(5):1290-8.
2003: Paul M O'Neill; Amira Mukhtar; Paul A Stocks; Laura E Randle; Stephen Hindley; Stephen A Ward; Richard C Storr; Jamie F Bickley; Ian A O'Neil; James L Maggs; Ruth H Hughes; Peter A Winstanley; Patrick G Bray; B Kevin Park
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Journal of medicinal chemistry 2003;46(23):4933-45.
2003: Giancarlo A Biagini; Paul M O'Neill; Alexis Nzila; Stephen A Ward; Patrick G Bray
Antimalarial chemotherapy: young guns or back to the future?
Trends in parasitology 2003;19(11):479-87.
2003: Ursula Eckstein-Ludwig; RJ Webb; I D A Van Goethem; J Malcolm East; Anthony G Lee; M Kimura; Paul M O'Neill; Patrick G Bray; S A Ward; Sanjeev Krishna
Artemisinins target the SERCA of Plasmodium falciparum.
Nature 2003;424(6951):957-61.
2002: Paul A Stocks; Kaylene J Raynes; Patrick G Bray; B Kevin Park; Paul M O'Neill; Stephen A Ward
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Journal of medicinal chemistry 2002;45(23):4975-83.
2002: Stephen Hindley; Stephen A Ward; Richard C Storr; Natalie L Searle; Patrick G Bray; B Kevin Park; Jill Davies; Paul M O'Neill
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
Journal of medicinal chemistry 2002;45(5):1052-63.
2001: Paul M O'Neill; Feodor Scheinmann; Andrew V Stachulski; James L Maggs; B Kevin Park
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.
Journal of medicinal chemistry 2001;44(9):1467-70.
2001: Paul M O'Neill; A Miller; Laurence P D Bishop; Stephen Hindley; James L Maggs; Stephen A Ward; S M Roberts; Feodor Scheinmann; Andrew V Stachulski; G H Posner; B Kevin Park
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
Journal of medicinal chemistry 2001;44(1):58-68.
2001: B Kevin Park; Neil R Kitteringham; Paul M O'Neill
Metabolism of fluorine-containing drugs.
Annual review of pharmacology and toxicology 2001;41():443-70.
2000: Paul M O'Neill; Laurence P D Bishop; Natalie L Searle; James L Maggs; Richard C Storr; Stephen A Ward; B Kevin Park; F Mabbs
Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.
The Journal of organic chemistry 2000;65(5):1578-82.
2000: James L Maggs; Laurence P D Bishop; Geoffrey Edwards; Paul M O'Neill; Stephen A Ward; Peter A Winstanley; B Kevin Park
Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):209-17.
1999: Paul M O'Neill; Natalie L Searle; K W Kan; Richard C Storr; James L Maggs; Stephen A Ward; Kaylene J Raynes; B Kevin Park
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether.
Journal of medicinal chemistry 1999;42(26):5487-93.
1999: Kaylene J Raynes; Paul A Stocks; Paul M O'Neill; B Kevin Park; Stephen A Ward
New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.
Journal of medicinal chemistry 1999;42(15):2747-51.
1999: Laurence P D Bishop; James L Maggs; Paul M O'Neill; B Kevin Park
Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation.
The Journal of pharmacology and experimental therapeutics 1999;289(1):511-20.
1998: B Kevin Park; Paul M O'Neill; James L Maggs; Munir Pirmohamed
Safety assessment of peroxide antimalarials: clinical and chemical perspectives.
British journal of clinical pharmacology 1998;46(6):521-9.
1998: Dean J Naisbitt; Dominic P Williams; Paul M O'Neill; James L Maggs; D J Willock; Munir Pirmohamed; B Kevin Park
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.
Chemical research in toxicology 1998;11(12):1586-95.
1998: J E Ruscoe; MD Tingle; Paul M O'Neill; Stephen A Ward; B Kevin Park
Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology.
Antimicrobial agents and chemotherapy 1998;42(9):2410-6.
1998: S R Hawley; Patrick G Bray; Mathirut Mungthin; J D Atkinson; Paul M O'Neill; S A Ward
Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.
Antimicrobial agents and chemotherapy 1998;42(3):682-6.
1998: Paul M O'Neill; Patrick G Bray; S R Hawley; Stephen A Ward; B Kevin Park
4-Aminoquinolines--past, present, and future: a chemical perspective.
Pharmacology & therapeutics 1998;77(1):29-58.
1997: James L Maggs; S Madden; Laurence P D Bishop; Paul M O'Neill; B Kevin Park
The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1200-4.
1997: Paul M O'Neill; D J Willock; S R Hawley; Patrick G Bray; Richard C Storr; Stephen A Ward; B Kevin Park
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
Journal of medicinal chemistry 1997;40(4):437-48.
1997: Dean J Naisbitt; J E Ruscoe; D Williams; Paul M O'Neill; Munir Pirmohamed; B Kevin Park
Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.
The Journal of pharmacology and experimental therapeutics 1997;280(2):884-93.
1996: Paul M O'Neill; Laurence P D Bishop; Richard C Storr; S R Hawley; James L Maggs; Stephen A Ward; B Kevin Park
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.
Journal of medicinal chemistry 1996;39(22):4511-4.
1996: S R Hawley; Patrick G Bray; Paul M O'Neill; Dean J Naisbitt; B Kevin Park; Stephen A Ward
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.
Antimicrobial agents and chemotherapy 1996;40(10):2345-9.
1996: S R Hawley; Patrick G Bray; Paul M O'Neill; B Kevin Park; Stephen A Ward
The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.
Biochemical pharmacology 1996;52(5):723-33.
1995: MD Tingle; H Jewell; James L Maggs; Paul M O'Neill; B Kevin Park
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.
Biochemical pharmacology 1995;50(7):1113-9.
1995: J E Ruscoe; H Jewell; James L Maggs; Paul M O'Neill; Richard C Storr; Stephen A Ward; B Kevin Park
The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.
The Journal of pharmacology and experimental therapeutics 1995;273(1):393-404.
1995: H Jewell; James L Maggs; A C Harrison; Paul M O'Neill; J E Ruscoe; B Kevin Park
Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(2):199-217.
1994: Paul M O'Neill; A C Harrison; Richard C Storr; S R Hawley; Stephen A Ward; B Kevin Park
The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.
Journal of medicinal chemistry 1994;37(9):1362-70.
1993: S Barnard; Richard C Storr; Paul M O'Neill; B Kevin Park
The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol.
The Journal of pharmacy and pharmacology 1993;45(8):736-44.