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John Ong'echa

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Kenya

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Publications

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Winnie A Okeyo; Wilson Okumu; John M Ong'echa; Samuel B Anyona; Elly O Munde; Douglas J Perkins; Evans Raballah; John M Vulule; Collins Ouma
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.
Ariel L Rivas; Daniel Schwarz; Tom Were; Wilfried Wolter; Renata Piccinini; Rachel Pilla; Kevin L Anderson; Shlomo Blum; Marcelo Chaffer; Claus-Peter Czerny; Ulrike S Diesterbeck; Jeanne M Fair; James B Hittner; Almira L Hoogesteijn; James M Hyman; Mark D Jankowski; Prakash Kempaiah; Stephen N Konah; Gabriel Leitner; John M Ong'echa; Douglas J Perkins
Feedback-based, system-level properties of vertebrate-microbial interactions.
Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.

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All Publications

2013: Winnie A Okeyo; Wilson Okumu; John M Ong'echa; Samuel B Anyona; Elly O Munde; Douglas J Perkins; Evans Raballah; John M Vulule; Collins Ouma
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.
BMC immunology 2013;14():15.
2013: Ariel L Rivas; Daniel Schwarz; Tom Were; Wilfried Wolter; Renata Piccinini; Rachel Pilla; Kevin L Anderson; Shlomo Blum; Marcelo Chaffer; Claus-Peter Czerny; Ulrike S Diesterbeck; Jeanne M Fair; James B Hittner; Almira L Hoogesteijn; James M Hyman; Mark D Jankowski; Prakash Kempaiah; Stephen N Konah; Gabriel Leitner; John M Ong'echa; Douglas J Perkins
Feedback-based, system-level properties of vertebrate-microbial interactions.
PloS one 2013;8(2):e53984.
2012: Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.
American journal of hematology 2012;87(8):782-9.
2012: Prakasha Kempaiah; John M Ong'echa; Samuel B Anyona; Gregory C Davenport; James B Hittner; Evans Raballah; Tom Were; Douglas J Perkins
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.
Human genetics 2012;131(8):1375-91.
2012: Gregory C Davenport; James B Hittner; John M Ong'echa; Tom Were; Douglas J Perkins
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.
American journal of hematology 2012;87(7):652-8.
2012: Kingsley Badu; Andrew Githeko; John Larbi; John M Ong'echa; Douglas J Perkins; Virginia Ann Stewart; John Waitumbi; Yaw Asare Afrane; Evelina Angov; Guofa Zhou; Guiyun Yan
Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands.
BMC infectious diseases 2012;12():50.
2011: Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Collins Ouma; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
Infection and immunity 2011;79(12):4923-32.
2011: John M Ong'echa; Gregory C Davenport; James B Hittner; John M Vulule; Douglas J Perkins
Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.
Infection and immunity 2011;79(11):4674-80.
2011: Douglas J Perkins; Tom Were; Gregory C Davenport; James B Hittner; Prakasha Kempaiah; John M Ong'echa
Severe malarial anemia: innate immunity and pathogenesis.
International journal of biological sciences 2011;7(9):1427-42.
2011: John M Ong'echa; Collins Ouma; Evans O Raballah; John M Vulule; Tom Were; Samuel B Anyona; Gregory C Davenport; James B Hittner; Prakasha M Kempaiah; Stephen Konah; Douglas J Perkins
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.
BMC genetics 2011;12():69.
2010: Enrico M Novelli; James B Hittner; Gregory C Davenport; Collins Ouma; Tom Were; Stephen Obaro; Sandra Kaplan; John M Ong'echa; Douglas J Perkins
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.
British journal of haematology 2010;149(5):711-21.
2010: Gregory C Davenport; Collins Ouma; James B Hittner; Tom Were; Yamo Ouma; John M Ong'echa; Douglas J Perkins
Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1.
American journal of hematology 2010;85(4):227-33.
2010: Collins Ouma; Christopher C Keller; Gregory C Davenport; Tom Were; Stephen Konah; Michael F Otieno; James B Hittner; John M Vulule; Jeremy Martinson; John M Ong'echa; Robert E Ferrell; Douglas J Perkins
A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.
Infection and immunity 2010;78(1):453-60.
2009: Christopher C Keller; Collins Ouma; Yamo Ouma; Gordon A Awandare; Gregory C Davenport; Were Tom; James B Hittner; John M Vulule; John M Ong'echa; Douglas J Perkins
Suppression of a novel hematopoietic mediator in children with severe malarial anemia.
Infection and immunity 2009;77(9):3864-71.
2009: Gordon A Awandare; Jeremy Martinson; Were Tom; Collins Ouma; Gregory C Davenport; John M Ong'echa; Wenkui Wang; Lin Leng; Robert E Ferrell; Richard Bucala; Douglas J Perkins
MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.
The Journal of infectious diseases 2009;200(4):629-37.
2009: Tom Were; Gregory C Davenport; Emmanuel O Yamo; James B Hittner; Gordon A Awandare; Michael F Otieno; Collins Ouma; Alloys S S Orago; John M Vulule; John M Ong'echa; Douglas J Perkins
Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.
Microbes and infection / Institut Pasteur 2009;11(8-9):811-9.
2008: Collins Ouma; Gregory C Davenport; Tom Were; Michael F Otieno; James B Hittner; John M Vulule; Jeremy Martinson; John M Ong'echa; Robert E Ferrell; Douglas J Perkins
Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.
Human genetics 2008;124(5):515-24.
2008: Collins Ouma; Gregory C Davenport; Gordon A Awandare; Christopher C Keller; Tom Were; Michael F Otieno; John M Vulule; Jeremy Martinson; John M Ong'echa; Robert E Ferrell; Douglas J Perkins
Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.
The Journal of infectious diseases 2008;198(8):1219-26.
2008: John M Ong'echa; Allison M Remo; Jan Kristoff; James B Hittner; Were Tom; Collins Ouma; Richard O Otieno; John M Vulule; Christopher C Keller; Gordon A Awandare; Douglas J Perkins
Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.
Clinical immunology (Orlando, Fla.) 2008;126(2):211-21.
2007: Gordon A Awandare; Yamo Ouma; Collins Ouma; Were Tom; Richard O Otieno; Christopher C Keller; Gregory C Davenport; James B Hittner; John M Vulule; Robert E Ferrell; John M Ong'echa; Douglas J Perkins
Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.
Infection and immunity 2007;75(1):201-10.
2006: Were Tom; James B Hittner; Collins Ouma; Richard O Otieno; Alloys S S Orago; John M Ong'echa; John M Vulule; Christopher C Keller; Douglas J Perkins
Suppression of RANTES in children with Plasmodium falciparum malaria.
Haematologica 2006;91(10):1396-9.
2006: Gordon A Awandare; Collins Ouma; Christopher C Keller; Were Tom; Richard O Otieno; Y Ouma; Gregory C Davenport; James B Hittner; John M Ong'echa; Robert E Ferrell; Douglas J Perkins
A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria.
Genes and immunity 2006;7(7):568-75.
2006: Christopher C Keller; Ouma Yamo; Collins Ouma; John M Ong'echa; David Ounah; James B Hittner; John M Vulule; Douglas J Perkins
Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.
Infection and immunity 2006;74(9):5249-60.
2006: Collins Ouma; Christopher C Keller; Dorothy A Opondo; Were Tom; Richard O Otieno; Michael F Otieno; Alloys S S Orago; John M Ong'echa; John M Vulule; Robert E Ferrell; Douglas J Perkins
Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.
The American journal of tropical medicine and hygiene 2006;74(4):573-7.
2006: John M Ong'echa; Christopher C Keller; Were Tom; Collins Ouma; Richard O Otieno; Zachary Landis-Lewis; Daniel Ochiel; Jamie L Slingluff; Stephen Mogere; George A Ogonji; Alloys S S Orago; John M Vulule; Sandra S Kaplan; Richard D Day; Douglas J Perkins
Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.
The American journal of tropical medicine and hygiene 2006;74(3):376-85.
2006: Richard O Otieno; Collins Ouma; John M Ong'echa; Christopher C Keller; Were Tom; Eliud N Waindi; Marian G Michaels; Richard D Day; John M Vulule; Douglas J Perkins
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.
AIDS (London, England) 2006;20(2):275-80.
2005: Benjamin K Nti; Jamie L Slingluff; Christopher C Keller; James B Hittner; John M Ong'echa; Michael Murphey-Corb; Douglas J Perkins
Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-alpha regulation and viral replication.
AIDS (London, England) 2005;19(16):1771-80.
2003: John M Ong'echa; Altaf A Lal; Dianne J Terlouw; Feiko O ter Kuile; Simon K Kariuki; Venkatachalam Udhayakumar; Alloys S S Orago; Allen W Hightower; Bernard L Nahlen; Ya Ping Shi
Association of interferon-gamma responses to pre-erythrocytic stage vaccine candidate antigens of Plasmodium falciparum in young Kenyan children with improved hemoglobin levels: XV. Asembo Bay Cohort Project.
The American journal of tropical medicine and hygiene 2003;68(5):590-7.
2003: Simon K Kariuki; Altaf A Lal; Dianne J Terlouw; Feiko O ter Kuile; John M Ong'echa; Penelope A Phillips-Howard; Alloys S S Orago; Margarette S Kolczak; William A Hawley; Bernard L Nahlen; Ya Ping Shi
Effects of permethrin-treated bed nets on immunity to malaria in western Kenya II. Antibody responses in young children in an area of intense malaria transmission.
The American journal of tropical medicine and hygiene 2003;68(4 Suppl):108-14.