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Mitsuho Onimaru

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Yoshikazu Yonemitsu; Kumi Yoshida; Hiroshi Ban; Mamoru Hasegawa; Hiroyuki Inoguchi; Makoto Inoue; H Itoh; Ryoichi Kyuragi; Takuya Matsumoto; Yoichi Nakanishi; J Okazaki; Mitsuho Onimaru; Toshihiro Onohara; Mototsugu Shimokawa; Tsugumine Shu; Michiko Tanaka; Makiko Uchiyama; Yoshihiko Maehara
DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial.
Mie Imai; Hiroaki Ishibashi; Takahiro Kanno; Yoshiki Nariai; Mitsuho Onimaru; Joji Sekine; Yoshihide Mori
Transfection of hypoxia-inducible factor-1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells.
Nouval Shahab; Fumi Takahashi-Yanaga; Shunichi Kajioka; Miho Matsuda; Mitsuho Onimaru; Narihito Seki; Seiji Naito
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.

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All Publications

2013: Yoshikazu Yonemitsu; Kumi Yoshida; Hiroshi Ban; Mamoru Hasegawa; Hiroyuki Inoguchi; Makoto Inoue; H Itoh; Ryoichi Kyuragi; Takuya Matsumoto; Yoichi Nakanishi; J Okazaki; Mitsuho Onimaru; Toshihiro Onohara; Mototsugu Shimokawa; Tsugumine Shu; Michiko Tanaka; Makiko Uchiyama; Yoshihiko Maehara
DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(3):707-14.
2012: Mie Imai; Hiroaki Ishibashi; Takahiro Kanno; Yoshiki Nariai; Mitsuho Onimaru; Joji Sekine; Yoshihide Mori
Transfection of hypoxia-inducible factor-1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2012;41(9):675-81.
2012: Nouval Shahab; Fumi Takahashi-Yanaga; Shunichi Kajioka; Miho Matsuda; Mitsuho Onimaru; Narihito Seki; Seiji Naito
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.
Neurourology and urodynamics 2012;31(4):593-9.
2012: Yosuke Morodomi; Mitsuho Onimaru; Satoru Saito; Yasunori Shikada; Fumihiro Shoji; Tokujiro Yano; Yui Harada; Mamoru Hasegawa; Kensaku Ito; Hiroaki Kinoh; Ryoichi Kyuragi; Yoshihiko Maehara; Riichiroh Maruyama; Kumi Yoshida; Tsukihisa Yoshida; Yoshikazu Yonemitsu
BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(4):769-77.
2012: Shunichi Kajioka; Miho Matsuda; Sachio Morimoto; Hiromitsu Morita; Haruhiko Asano; Maya Hayashi; Masato Hirata; Shinsuke Nakayama; Mitsuho Onimaru; Toshiuyki Sasaguri; Narihito Seki; Nouval Shahab; Ryosuke Takahashi; Fumi Takahashi-Yanaga; Yoshikazu Yonemitsu; Seiji Naito
Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction.
Scientific reports 2012;2():979.
2011: Fumihiro Shoji; Tokujiro Yano; Tsukihisa Yoshida; Naoko Miura; Yosuke Morodomi; Mitsuho Onimaru; Yoshihiko Maehara
Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump.
Interactive cardiovascular and thoracic surgery 2011;13(3):271-5.
2011: Nobuaki Kurata; Prawej Mahawithitwong; Tatsuya Manabe; Kazuhiro Mizumoto; Takao Ohtsuka; Kenoki Ohuchida; Mitsuho Onimaru; Hiroshi Sakai; Hayato Fujita; Masao Tanaka
Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil.
International journal of oncology 2011;39(2):473-82.
2011: Hayato Fujita; Kenoki Ohuchida; Kazuhiro Mizumoto; Soichi Itaba; Tetsuhide Ito; Kohei Nakata; Jun Yu; Tadashi Kayashima; Akifumi Hayashi; Ryota Souzaki; Tatsuro Tajiri; Mitsuho Onimaru; Tatsuya Manabe; Takao Ohtsuka; Masao Tanaka
High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy.
International journal of oncology 2011;38(3):629-41.
2011: Masahiko Sugiyama; Yoshihiro Kakeji; Shunichi Tsujitani; Yui Harada; Mitsuho Onimaru; Kumi Yoshida; Sakura Tanaka; Yasunori Emi; Masaru Morita; Yosuke Morodomi; Mamoru Hasegawa; Yoshihiko Maehara; Yoshikazu Yonemitsu
Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites.
Molecular cancer therapeutics 2011;10(3):540-9.
2011: Hanako Suzuki; Mitsuho Onimaru; Takaomi Koga; Masafumi Takeshita; Tokujiro Yano; Yoshihiko Maehara; Seiji Nakamura; Katsuo Sueishi
High podoplanin expression in cancer cells predicts lower incidence of nodal metastasis in patients with lung squamous cell carcinoma.
Pathology, research and practice 2011;207(2):111-5.
2011: Mitsuho Onimaru; Yoshikazu Yonemitsu
Angiogenic and lymphangiogenic cascades in the tumor microenvironment.
Frontiers in bioscience (Scholar edition) 2011;3():216-25.
2010: Yuzo Hasegawa; Hiroaki Kinoh; Yasuo Iwadate; Mitsuho Onimaru; Yasuji Ueda; Yui Harada; Satoru Saito; Aki Furuya; Takashi Saegusa; Yosuke Morodomi; Mamoru Hasegawa; Shigeyoshi Saito; Ichio Aoki; Naokatsu Saeki; Yoshikazu Yonemitsu
Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(10):1778-86.
2010: Mitsuho Onimaru; Kenoki Ohuchida; T Egami; Kazuhiro Mizumoto; Eishi Nagai; L Cui; H Toma; Kunihiro Matsumoto; M Hashizume; Masao Tanaka
Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.
Cancer gene therapy 2010;17(8):541-9.
2010: Mitsuho Onimaru; Yoshikazu Yonemitsu; Hanako Suzuki; Takaaki Fujii; Katsuo Sueishi
An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):818-26.
2010: Hanako Suzuki; Mitsuho Onimaru; Yoshikazu Yonemitsu; Yoshihiko Maehara; Seiji Nakamura; Katsuo Sueishi
Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells.
Molecular cancer 2010;9():287.
2009: Mitsuho Onimaru; Yoshikazu Yonemitsu; Takaaki Fujii; Mitsugu Tanii; Toshiaki Nakano; Kazunori Nakagawa; Ri-ichiro Kohno; Mamoru Hasegawa; Shin-ichi Nishikawa; Katsuo Sueishi
VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B.
American journal of physiology. Heart and circulatory physiology 2009;297(5):H1685-96.
2009: Masaki Matsuura; Mitsuho Onimaru; Yoshikazu Yonemitsu; Hanako Suzuki; Toshiaki Nakano; Hiroaki Ishibashi; Kanemitsu Shirasuna; Katsuo Sueishi
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells.
The American journal of pathology 2009;175(4):1709-21.
2008: Yusuke Murakami; Yasuhiro Ikeda; Yoshikazu Yonemitsu; Mitsuho Onimaru; Kazunori Nakagawa; Ri-ichiro Kohno; Masanori Miyazaki; Toshio Hisatomi; Makoto Nakamura; Takeshi Yabe; Mamoru Hasegawa; Tatsuro Ishibashi; Katsuo Sueishi
Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.
The American journal of pathology 2008;173(5):1326-38.
2008: Takaaki Fujii; Yoshikazu Yonemitsu; Mitsuho Onimaru; Makoto Inoue; Mamoru Hasegawa; Hiroyuki Kuwano; Katsuo Sueishi
VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis.
Atherosclerosis 2008;200(1):51-7.
2008: Takaaki Fujii; Mitsuho Onimaru; Yoshikazu Yonemitsu; Hiroyuki Kuwano; Katsuo Sueishi
Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2785-91.
2008: Takuya Egami; Kenoki Ohuchida; Kazuhiro Mizumoto; Mitsuho Onimaru; Hiroki Toma; Shoko Nishio; Eishi Nagai; Kunio Matsumoto; Toshikazu Nakamura; Masao Tanaka
Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(6):1859-67.
2006: Takaaki Fujii; Yoshikazu Yonemitsu; Mitsuho Onimaru; Mitsugu Tanii; Toshiaki Nakano; Kensuke Egashira; Takako Takehara; Makoto Inoue; Mamoru Hasegawa; Hiroyuki Kuwano; Katsuo Sueishi
Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2483-9.
2006: Yasuhiro Ikeda; Yoshikazu Yonemitsu; Mitsuho Onimaru; Toshiaki Nakano; Masanori Miyazaki; Ri-ichiro Kohno; Kazunori Nakagawa; Akifumi Ueno; Katsuo Sueishi; Tatsuro Ishibashi
The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium.
Experimental eye research 2006;83(5):1031-40.
2006: Satoko Shibata; Shinji Okano; Yoshikazu Yonemitsu; Mitsuho Onimaru; Shihoko Sata; Hiroko Nagata-Takeshita; Makoto Inoue; Tsugumine Zhu; Mamoru Hasegawa; Yoichi Moroi; masutaka furue; Katsuo Sueishi
Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-beta gene.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3564-76.
2006: Kazuhiro Kaneko; Yoshikazu Yonemitsu; Takaaki Fujii; Mitsuho Onimaru; Chen-Hao Jin; Makoto Inoue; Mamoru Hasegawa; Toshihiro Onohara; Yoshihiko Maehara; Katsuo Sueishi
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1484-92.
2006: Mitsugu Tanii; Yoshikazu Yonemitsu; Takaaki Fujii; Yasunori Shikada; Ri-ichiro Kohno; Mitsuho Onimaru; Shinji Okano; Makoto Inoue; Mamoru Hasegawa; Toshihiro Onohara; Yoshihiko Maehara; Katsuo Sueishi
Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors.
Circulation research 2006;98(1):55-62.
2005: Hiromitsu Baba; Yoshikazu Yonemitsu; Toshiaki Nakano; Mitsuho Onimaru; Masanori Miyazaki; Yasuhiro Ikeda; Shinji Sumiyoshi; Yasuji Ueda; Mamoru Hasegawa; Ichiro Yoshino; Yoshihiko Maehara; Katsuo Sueishi
Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1938-44.
2005: Yasunori Shikada; Yoshikazu Yonemitsu; Takaomi Koga; Mitsuho Onimaru; Toshiaki Nakano; Shinji Okano; Shihoko Sata; Kazunori Nakagawa; Ichiro Yoshino; Yoshihiko Maehara; Katsuo Sueishi
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas.
Cancer research 2005;65(16):7241-8.
2004: Norifumi Tsutsumi; Yoshikazu Yonemitsu; Yasunori Shikada; Mitsuho Onimaru; Mitsugu Tanii; Shinji Okano; Kazuhiro Kaneko; Mamoru Hasegawa; Makoto Hashizume; Yoshihiko Maehara; Katsuo Sueishi
Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis.
Circulation research 2004;94(9):1186-94.
2003: Shinji Okano; Yoshikazu Yonemitsu; S Nagata; Shihoko Sata; Mitsuho Onimaru; Kazunori Nakagawa; Y Tomita; K Kishihara; S Hashimoto; Yutaka Nakashima; Keishi Sugimachi; Mamoru Hasegawa; Katsuo Sueishi
Recombinant Sendai virus vectors for activated T lymphocytes.
Gene therapy 2003;10(16):1381-91.
2002: Mitsuho Onimaru; Yoshikazu Yonemitsu; Mitsugu Tanii; Kazunori Nakagawa; Ichiro Masaki; Shinji Okano; Hiroaki Ishibashi; Kanemitsu Shirasuna; Mamoru Hasegawa; Katsuo Sueishi
Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs.
Circulation research 2002;91(10):923-30.
2001: Hiroaki Ishibashi; T Shiratuchi; Kazunori Nakagawa; Mitsuho Onimaru; Tsuyoshi Sugiura; Katsuo Sueishi; Kanemitsu Shirasuna
Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release.
Oral oncology 2001;37(1):77-83.
2000: Hiroaki Ishibashi; Kazunori Nakagawa; Mitsuho Onimaru; E J Castellanous; Yasufumi Kaneda; Yutaka Nakashima; Kanemitsu Shirasuna; Katsuo Sueishi
Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities.
Cancer research 2000;60(22):6531-6.