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Hiraku Ono

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Xinglong Cui; Akifumi Kushiyama; Masayasu Yoneda; Yusuke Nakatsu; Ying Guo; Jun Zhang; Hiraku Ono; Machi Kanna; Hideyuki Sakoda; Hiraku Ono; Takako Kikuchi; Midori Fujishiro; Masashi Shiomi; Hideaki Kamata; Hiroki Kurihara; Masatoshi Kikuchi; Shoji Kawazu; Fusanori Nishimura; Tomoichiro Asano
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Yuko Koketsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Hiraku Ono; Motonobu Anai; Takako Kikuchi; Takeshi Fukuda; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.
Hiraku Ono; Hideyuki Sakoda; Midori Fujishiro; Motonobu Anai; Akifumi Kushiyama; Yasushi Fukushima; Hideki Katagiri; Takehide Ogihara; Yoshitomo Oka; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.

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All Publications

2010: Xinglong Cui; Akifumi Kushiyama; Masayasu Yoneda; Yusuke Nakatsu; Ying Guo; Jun Zhang; Hiraku Ono; Machi Kanna; Hideyuki Sakoda; Hiraku Ono; Takako Kikuchi; Midori Fujishiro; Masashi Shiomi; Hideaki Kamata; Hiroki Kurihara; Masatoshi Kikuchi; Shoji Kawazu; Fusanori Nishimura; Tomoichiro Asano
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Diabetes research and clinical practice 2010;87(1):57-63.
2008: Yuko Koketsu; Hideyuki Sakoda; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Hiraku Ono; Motonobu Anai; Takako Kikuchi; Takeshi Fukuda; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E719-25.
2007: Hiraku Ono; Hideyuki Sakoda; Midori Fujishiro; Motonobu Anai; Akifumi Kushiyama; Yasushi Fukushima; Hideki Katagiri; Takehide Ogihara; Yoshitomo Oka; Hideaki Kamata; Nanao Horike; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
American journal of physiology. Cell physiology 2007;293(5):C1576-85.
2006: Amelia Y I Viana; Hideyuki Sakoda; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Akifumi Kushiyama; Yasushi Fukushima; Yuzo Sato; Yoshiharu Oshida; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.
Diabetes research and clinical practice 2006;73(2):135-42.
2005: Akifumi Kushiyama; Nobuhiro Shojima; Takehide Ogihara; Kouichi Inukai; Hideyuki Sakoda; Midori Fujishiro; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Koichi Nishiyama; Tatsuo Shimosawa; Toshiro Fujita; Hideki Katagiri; Yoshitomo Oka; Hiroki Kurihara; Tomoichiro Asano
Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
The Journal of biological chemistry 2005;280(51):42016-25.
2005: Hideyuki Sakoda; Midori Fujishiro; Junko Fujio; Nobuhiro Shojima; Takehide Ogihara; Akifumi Kushiyama; Yasushi Fukushima; Motonobu Anai; Hiraku Ono; Masatoshi Kikuchi; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E474-81.
2005: Motonobu Anai; Nobuhiro Shojima; Hideki Katagiri; Takehide Ogihara; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Yasushi Fukushima; Nanao Horike; Amelia Y I Viana; Masatoshi Kikuchi; Noriko Noguchi; Shinichiro Takahashi; Kuniaki Takata; Yoshitomo Oka; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
The Journal of biological chemistry 2005;280(18):18525-35.
2005: Nobuhiro Shojima; Toshio Ogihara; Kouichi Inukai; Midori Fujishiro; Hideyuki Sakoda; Akifumi Kushiyama; Hideki Katagiri; Motonobu Anai; Hiraku Ono; Yasushi Fukushima; Nanao Horike; Amelia Y I Viana; Yasunobu Uchijima; Hiroki Kurihara; Tomoichiro Asano
Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.
Diabetologia 2005;48(5):984-92.
2004: Yasushi Fukushima; Toshimitsu Matsui; Toshihito Saitoh; Masao Ichinose; Keisuke Tateishi; Takayuki Shindo; Midori Fujishiro; Hideyuki Sakoda; Nobuhiro Shojima; Akifumi Kushiyama; Satoru Fukuda; Motonobu Anai; Hiraku Ono; Masashi Oka; Yasuhito Shimizu; Hiroki Kurihara; Ryozo Nagai; Takashi Ishikawa; Tomoichiro Asano; Masao Omata
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
European journal of pharmacology 2004;502(3):243-52.
2004: Tomoichiro Asano; Takehide Ogihara; Hideki Katagiri; Hideyuki Sakoda; Hiraku Ono; Midori Fujishiro; Motonobu Anai; Hiroki Kurihara; Yasunobu Uchijima
Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs.
Current medicinal chemistry 2004;11(20):2717-24.
2004: Toshio Ogihara; Tomoichiro Asano; Hideki Katagiri; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Midori Fujishiro; Akifumi Kushiyama; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Yukiko Gotoh; Issei Komuro; Toshiro Fujita
Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Diabetologia 2004;47(5):794-805.
2003: Hiraku Ono; Hitoshi Shimano; Hideki Katagiri; Naoya Yahagi; Hideyuki Sakoda; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Amelia Y I Viana; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Diabetes 2003;52(12):2905-13.
2003: Hideyuki Sakoda; Yukiko Gotoh; Hideki Katagiri; Mineo Kurokawa; Hiraku Ono; Yukiko Onishi; Motonobu Anai; Takehide Ogihara; Midori Fujishiro; Yasushi Fukushima; Miho Abe; Nobuhiro Shojima; Masatoshi Kikuchi; Yoshitomo Oka; Hisamaru Hirai; Tomoichiro Asano
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.
The Journal of biological chemistry 2003;278(28):25802-7.
2003: Yasushi Fukushima; Takayuki Shindo; Motonobu Anai; Toshihito Saitoh; Yuhui Wang; Midori Fujishiro; Yoshio Ohashi; Takehide Ogihara; Kouichi Inukai; Hiraku Ono; Hideyuki Sakoda; Yukiko Kurihara; Miho Honda; Nobuhiro Shojima; Harumi Fukushima; Yukiko Haraikawa-Onishi; Hideki Katagiri; Yasuhito Shimizu; Masao Ichinose; Takashi Ishikawa; Masao Omata; Ryozo Nagai; Hiroki Kurihara; Tomoichiro Asano
Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.
European journal of pharmacology 2003;468(1):47-58.
2003: Midori Fujishiro; Yukiko Gotoh; Hideki Katagiri; Hideyuki Sakoda; Takehide Ogihara; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Miho Abe; Nobuhiro Shojima; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2003;17(3):487-97.
2003: Yasushi Fukushima; Takashi Ishikawa; Toshihito Saitoh; Keisuke Tateishi; Takehide Ogihara; Midori Fujishiro; Nobuhiro Shojima; Miho Honda; Akifumi Kushiyama; Motonobu Anai; Hideyuki Sakoda; Hiraku Ono; Yukiko Onishi; Hiroko Otsuka; Hideki Katagiri; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells.
Digestion 2003;68(2-3):145-52.
2002: Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Yuko Chiba; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Hideki Katagiri; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Issei Komuro; Toshiro Fujita
Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.
Hypertension 2002;40(6):872-9.
2002: Haiyan Song; Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Hitoshi Shimano; Nobuhiro Yamada; Yoshitomo Oka; Tomoichiro Asano
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.
Biochemical and biophysical research communications 2002;299(2):291-8.
2002: Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Toshiro Fujita
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
Hypertension 2002;40(1):83-9.
2002: Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
Diabetes 2002;51(6):1737-44.
2002: Hideyuki Sakoda; Takehide Ogihara; Motonobu Anai; Midori Fujishiro; Hiraku Ono; Yukiko Onishi; Hideki Katagiri; Miho Abe; Yasushi Fukushima; Nobuhiro Shojima; Kouichi Inukai; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1239-44.
2001: Miho Honda; H Okutsu; T Matsuura; T Miyagi; Y Yamamoto; T Hazato; Hiraku Ono
Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice.
Japanese journal of pharmacology 2001;87(4):261-7.
2001: Y Onishi-Haraikawa; Masako Funaki; N Gotoh; Masabumi Shibuya; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Motonobu Anai; Toshio Ogihara; Hideyuki Sakoda; Hiraku Ono; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.
Biochemical and biophysical research communications 2001;288(2):476-82.
2001: Hiraku Ono; Hideki Katagiri; Masako Funaki; Motonobu Anai; Kouichi Inukai; Yasushi Fukushima; Hideyuki Sakoda; Toshio Ogihara; Yukiko Onishi; Midori Fujishiro; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1411-22.
2001: Yasushi Fukushima; Tatsuya Saitoh; Motonobu Anai; Toshio Ogihara; Kouichi Inukai; Masako Funaki; Hideyuki Sakoda; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Takashi Ishikawa; K Takata; Ryozo Nagai; Masao Omata; Tomoichiro Asano
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.
Biochimica et biophysica acta 2001;1539(3):181-91.
2001: Midori Fujishiro; Yukiko Gotoh; Hideki Katagiri; Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Masako Funaki; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.
The Journal of biological chemistry 2001;276(23):19800-6.
2001: H Okada; Miho Honda; Hiraku Ono
Method for recording spinal reflexes in mice: effects of thyrotropin-releasing hormone, DOI, tolperisone and baclofen on monosynaptic spinal reflex potentials.
Japanese journal of pharmacology 2001;86(1):134-6.
2001: Toshio Ogihara; Tomoichiro Asano; K Ando; Yuko Chiba; N Sekine; Hideyuki Sakoda; Motonobu Anai; Yukiko Onishi; Midori Fujishiro; Hiraku Ono; Nobuhiro Shojima; Kouichi Inukai; Yasushi Fukushima; Masatoshi Kikuchi; T Fujita
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.
Diabetes 2001;50(3):573-83.
2001: T Yamazaki; Miho Honda; Y Yamamoto; T Hazato; Hiraku Ono
Effects of spinorphin and tynorphin on synaptic transmission in rat hippocampal slices.
European journal of pharmacology 2001;413(2-3):173-8.
2001: Yasushi Fukushima; Tatsuya Saitoh; Motonobu Anai; K Tsukuda; Yukiko Onishi; Hideyuki Sakoda; Kouichi Inukai; Toshio Ogihara; Masako Funaki; Hiraku Ono; Midori Fujishiro; Takashi Ishikawa; Ryozo Nagai; Masao Omata; Tomoichiro Asano
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.
The pharmacogenomics journal 2001;1(1):78-83.
2000: Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Masako Funaki; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Yukiko Onishi; Hiraku Ono; Midori Fujishiro; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Diabetes 2000;49(10):1700-8.
2000: Kouichi Inukai; Masako Funaki; Masao Nawano; Hideki Katagiri; Toshio Ogihara; Motonobu Anai; Yukiko Onishi; Hideyuki Sakoda; Hiraku Ono; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin.
The Biochemical journal 2000;346 Pt 2():483-9.
1999: Masako Funaki; Hideki Katagiri; A Kanda; Motonobu Anai; Masao Nawano; Toshio Ogihara; Kouichi Inukai; Yasushi Fukushima; Hiraku Ono; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring.
The Journal of biological chemistry 1999;274(31):22019-24.
1999: Hideyuki Sakoda; Toshio Ogihara; Motonobu Anai; Masako Funaki; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Yukiko Onishi; Hiraku Ono; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.
Diabetes 1999;48(7):1365-71.
1999: Miho Honda; Hiraku Ono
Differential effects of (R)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.
European journal of pharmacology 1999;373(2-3):171-9.
1998: Motonobu Anai; Hiraku Ono; Masako Funaki; Yasushi Fukushima; Kouichi Inukai; Toshio Ogihara; Hideyuki Sakoda; Yukiko Onishi; Yoshio Yazaki; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2.
The Journal of biological chemistry 1998;273(45):29686-92.
1998: T Otsu; T Nagao; Hiraku Ono
Muscle relaxant action of MS-322, a new centrally acting muscle relaxant, in rats.
General pharmacology 1998;30(3):393-8.
1997: Teiji Wada; Y Hasegawa; Hiraku Ono
Characterization of alpha1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity.
European journal of pharmacology 1997;340(1):45-52.
1996: Y Hasegawa; Hiraku Ono
Effects of 8-OH-DPAT, a 5-HT1A receptor agonist, and DOI, a 5-HT2A/2C agonist, on monosynaptic transmission in spinalized rats.
Brain research 1996;738(1):158-61.
1996: T Wada; T Otsu; Y Hasegawa; A Mizuchi; Hiraku Ono
Characterization of alpha 1-adrenoceptor subtypes in rat spinal cord.
European journal of pharmacology 1996;312(2):263-6.
1996: H Kobayashi; Y Hasegawa; Hiraku Ono
Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems.
European journal of pharmacology 1996;311(1):29-35.
1996: Y Hasegawa; Hiraku Ono
Effect of (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide on spinal motor systems in anesthetized intact and spinalized rats.
European journal of pharmacology 1996;295(2-3):211-4.
1995: Y Hasegawa; Hiraku Ono
Descending noradrenergic neurones tonically suppress spinal presynaptic inhibition in rats.
Neuroreport 1995;7(1):262-6.
1995: Hiraku Ono; H Fukuda
Pharmacology of descending noradrenergic systems in relation to motor function.
Pharmacology & therapeutics 1995;68(1):105-12.
1993: H Watanabe; M Tateyama; Taku Nagao; S Ohta; Masaaki Hirobe; Hiraku Ono
Methamphetamine antagonistic property of (+)- and (-)-4-phenyltetrahydroisoquinoline in rat anococcygeus muscle.
European journal of pharmacology 1993;243(2):155-61.
1993: M Tateyama; Taku Nagao; S Ohta; Masaaki Hirobe; Hiraku Ono
4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release.
European journal of pharmacology 1993;240(1):51-6.
1993: M Tateyama; S Ohta; Taku Nagao; Masaaki Hirobe; Hiraku Ono
Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat.
Neuropharmacology 1993;32(8):761-6.
1993: N Kamijo; Taku Nagao; Hiraku Ono
Depression of the monosynaptic reflex by apomorphine or bromocriptine is not mediated by D1/D2 receptors.
Neuropharmacology 1993;32(8):777-83.
1993: Hiraku Ono; C Fukushima; H Fukuda
Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Japanese journal of pharmacology 1993;62(4):357-62.
1993: M Tateyama; S Ohta; Taku Nagao; Masaaki Hirobe; Hiraku Ono
Effect of 4-phenyl-1,2,3,4-tetrahydroisoquinoline on ambulation induced by injection of methamphetamine into the nucleus accumbens in rats.
Neuropharmacology 1993;32(3):243-8.
1993: T Nakamura; Hiraku Ono; H Fukuda; M Tanabe; M Kozuka; N Iwata
Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine.
Biological & pharmaceutical bulletin 1993;16(1):33-5.
1992: M Satoh; S Ohta; Taku Nagao; Masaaki Hirobe; H Fukuda; Hiraku Ono
Amphetamine-antagonistic property of 4-phenyltetrahydroisoquinoline: effect on noradrenaline release in spinal cord slices.
Japanese journal of pharmacology 1992;60(2):121-5.
1992: Jun Yamazaki; H Fukuda; Taku Nagao; Hiraku Ono
5-HT2/5-HT1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices.
European journal of pharmacology 1992;220(2-3):237-42.
1992: Jun Yamazaki; Hiraku Ono; Taku Nagao
Stimulatory and inhibitory effects of serotonergic hallucinogens on spinal mono- and polysynaptic reflex pathways in the rat.
Neuropharmacology 1992;31(7):635-42.
1991: Hiraku Ono; Y Hasebe; M Satoh; Taku Nagao; S Ohta; Masaaki Hirobe; H Fuduka
Amphetamine-antagonistic properties of 4-phenyl-1,2,3,4- tetrahydroisoquinoline: inhibition of spinal reflex-enhancing effects of methamphetamine, phenylethylamine and nomifensine.
Brain research 1991;564(2):319-22.
1991: Hiraku Ono; S S Ono; H Fukuda
5-HT receptor-mediated regulation of thyrotropin-releasing hormone release in rat spinal cord.
European journal of pharmacology 1991;203(2):283-5.
1991: Hiraku Ono; A Mishima; S Ono; H Fukuda; M R Vasko
Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.
Neuropharmacology 1991;30(6):585-9.
1991: Hiraku Ono; Hiroshi Ito; H Fukuda
2-phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers.
Japanese journal of pharmacology 1991;55(3):359-66.
1991: T Hirayama; Hiraku Ono; H Fukuda
Functional supersensitivity of alpha 1-adrenergic system in spinal ventral horn is due to absence of an uptake system and not to postsynaptic change.
Brain research 1991;539(2):320-3.
1991: Fumio Umeda; K Noda; Hiraku Ono; Yoshiharu Chijiiwa; Hajime Nawata
Decreased vasoactive intestinal polypeptide (VIP) level in cerebrospinal fluid from diabetic patients with neuropathy.
Fukuoka igaku zasshi = Hukuoka acta medica 1991;82(1):17-20.
1990: T Hirayama; Hiraku Ono; H Fukuda
Effects of excitatory and inhibitory amino acid agonists and antagonists of ventral horn cells in slices of spinal cord isolated from adult rats.
Neuropharmacology 1990;29(12):1117-22.
1990: M Tanabe; Hiraku Ono; H Fukuda
Spinal alpha 1- and alpha 2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.
Japanese journal of pharmacology 1990;54(1):69-77.
1990: Hiraku Ono; K Saito; M Kondo; S Morishita; Koichi Kato; Y Hasebe; M Nakayama; F Kato; T Nakamura; M Satoh
Effects of the new centrally acting muscle relaxant 7-chloro-N,N,3-trimethylbenzo[b]furan-2-carboxamide on motor and central nervous systems in rats.
Arzneimittel-Forschung 1990;40(7):730-5.
1990: K Noda; Fumio Umeda; Hiraku Ono; A Hisatomi; Yoshiharu Chijiiwa; Hajime Nawata; H Ibayashi
Decreased VIP content in peripheral nerve from streptozocin-induced diabetic rats.
Diabetes 1990;39(5):608-12.
1990: Hiraku Ono; N Nagano; M Yamada; H Fukuda
Effects of a new analog of thyrotropin-releasing hormone, N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate (YM-14673) on spinal reflex potentials and flexor reflexes in spinalized rats.
Neuropharmacology 1990;29(1):69-74.
1990: T Suzuki; N Nagano; Hiraku Ono; H Fukuda
Different spinal effects of opioid agonists on spinal and spino-bulbo-spinal reflexes in rats.
Journal of neural transmission. General section 1990;79(1-2):1-9.
1989: Hiraku Ono; Y Hasebe; T Mori; H Fukuda; M Kohno; S Ohta; Masaaki Hirobe
Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats.
Journal of pharmacobio-dynamics 1989;12(7):384-91.
1989: Y Hasebe; Hiraku Ono; H Fukuda; S Ohta; Masaaki Hirobe
Enhancement of spinal monosynaptic reflexes with phenylethylamine and related drugs through descending noradrenergic neurons.
Journal of pharmacobio-dynamics 1989;12(4):241-5.
1989: Y Hasebe; Hiraku Ono; H Fukuda; S Ohta; Masaaki Hirobe
The most desirable conformation of phenylethylamine (PEA) moiety stimulating noradrenergic neurons: effects of PEA, methamphetamine, phenelzine, methylphenidate, nomifensine and mazindol on rat spinal reflexes.
General pharmacology 1989;20(3):375-9.
1989: J Yamazaki; K Matsumoto; Hiraku Ono; H Fukuda
Macrolide compounds, ivermectin and milbemycin D, stimulate chloride channels sensitive to GABAergic drugs in cultured chick spinal neurons.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1989;93(1):97-104.
1988: N Nagano; Hiraku Ono; M Ozawa; H Fukuda
The spinal reflex of chronic spinal rats is supersensitive to 5-HTP but not to TRH or 5-HT agonists.
European journal of pharmacology 1988;149(3):337-44.
1988: T Suzuki; Hiraku Ono; H Fukuda
Different effects of norepinephrine and serotonin on the electrical toe stimulation-induced reflexes in the rat spinal cord.
General pharmacology 1988;19(3):373-5.
1988: Hiraku Ono; M Tanabe; T Nakamura; N Nagano; H Fukuda
Effects of L-threo-dihydroxyphenylserine on spinal reflexes and decerebrate rigidity in rats.
General pharmacology 1988;19(3):369-72.
1988: N Nagano; Hiraku Ono; H Fukuda
Inhibitory effect of phencyclidine on rat spinal reflexes.
General pharmacology 1988;19(6):795-8.
1988: N Nagano; Hiraku Ono; H Fukuda
Functional significance of subtypes of 5-HT receptors in the rat spinal reflex pathway.
General pharmacology 1988;19(6):789-93.
1987: Hiraku Ono; M Miyamoto; M Kobayashi; H Fukuda
5-Hydroxytryptamine agonistic action of methysergide and the absence of supersensitivity to 5-HT agonists in spinal flexor reflexes in rats.
Neuropharmacology 1987;26(9):1371-5.
1987: T Kaneko; Hiraku Ono; H Fukuda
Enhancement of recurrent inhibition of the spinal monosynaptic reflex by preceding stimulation of the medullary raphé in rats.
Brain research 1987;417(2):403-7.
1987: N Nagano; Hiraku Ono; M Ozawa; H Fukuda
Sensitivity of spinal reflexes to TRH and 5-HT in 5,6-dihydroxytryptamine-treated rats.
European journal of pharmacology 1987;139(3):315-21.