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Brian O'Nuallain

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Alfred T Welzel; Angela D Williams; Hans P Schwarz; Alan Solomon; Dominic M Walsh; Alfred Weber; Luis Acero; Veronika Blinder; Sebastian Bunk; Hartmut J Ehrlich; Michael A Farrell; Corinna Hermann; Alex Mably; Helen P McWilliams-Koeppen; Brian O'Nuallain
Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.
Brian O'Nuallain; Michael J Rowan; Alfred Welzel; Andrew Barry; James P Cleary; Richard K Dykoski; James S Foster; Martijn F B G Gebbink; Igor Klyubin; Jessica M Mc Donald; Dominic M Walsh
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.
Brian O'Nuallain; Darragh B Freir; Andrew J Nicoll; Emmanuel Risse; Neil Ferguson; Caroline E Herron; John Collinge; Dominic M Walsh
Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.

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All Publications

2012: Alfred T Welzel; Angela D Williams; Hans P Schwarz; Alan Solomon; Dominic M Walsh; Alfred Weber; Luis Acero; Veronika Blinder; Sebastian Bunk; Hartmut J Ehrlich; Michael A Farrell; Corinna Hermann; Alex Mably; Helen P McWilliams-Koeppen; Brian O'Nuallain
Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.
PloS one 2012;7(11):e50317.
2011: Brian O'Nuallain; Michael J Rowan; Alfred Welzel; Andrew Barry; James P Cleary; Richard K Dykoski; James S Foster; Martijn F B G Gebbink; Igor Klyubin; Jessica M Mc Donald; Dominic M Walsh
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.
Journal of neurochemistry 2011;119(1):189-201.
2010: Brian O'Nuallain; Darragh B Freir; Andrew J Nicoll; Emmanuel Risse; Neil Ferguson; Caroline E Herron; John Collinge; Dominic M Walsh
Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14411-9.
2010: Brian O'Nuallain; Angela D Williams; Helen P McWilliams-Koeppen; Luis Acero; Alfred Weber; Hartmut Ehrlich; Hans P Schwarz; Alan Solomon
Anti-amyloidogenic activity of IgGs contained in normal plasma.
Journal of clinical immunology 2010;30 Suppl 1():S37-42.
2010: Sharad P Adekar; Igor Klyubin; Sally Macy; Michael J Rowan; Alan Solomon; Scott K Dessain; Brian O'Nuallain
Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains.
The Journal of biological chemistry 2010;285(2):1066-74.
2008: Brian O'Nuallain; Luis Acero; Angela D Williams; Helen P McWilliams Koeppen; Alfred Weber; Hans P Schwarz; Jonathan S. Wall; Deborah T Weiss; Alan Solomon
Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies.
Biochemistry 2008;47(47):12254-6.
2007: Brian O'Nuallain; Amy Allen; Demet Ataman; Deborah T Weiss; Alan Solomon; Jonathan S. Wall
Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope.
Biochemistry 2007;46(45):13049-58.
2007: Brian O'Nuallain; Amy Allen; Stephen J Kennel; Deborah T Weiss; Alan Solomon; Jonathan S. Wall
Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains.
Biochemistry 2007;46(5):1240-7.
2006: Brian O'Nuallain; Rudi Hrncic; Jonathan S. Wall; Deborah T Weiss; Alan Solomon
Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7071-8.
2006: Brian O'Nuallain; Ashwani K Thakur; Angela D Williams; Anusri M Bhattacharyya; Songming Chen; Geetha Thiagarajan; Ronald B. Wetzel
Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay.
Methods in enzymology 2006;413():34-74.
2005: Brian O'Nuallain; Shankaramma Shivaprasad; Indu Kheterpal; Ronald B. Wetzel
Thermodynamics of A beta(1-40) amyloid fibril elongation.
Biochemistry 2005;44(38):12709-18.
2005: Jonathan S. Wall; Stephen J Kennel; Michael J Paulus; Shaun Gleason; Jens Gregor; Justin Baba; Maria Schell; Tina Richey; Brian O'Nuallain; Robert Donnell; Philip N Hawkins; Deborah T Weiss; Alan Solomon
Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2005;12(3):149-56.
2004: Brian O'Nuallain; Angela D Williams; Per Westermark; Ronald B. Wetzel
Seeding specificity in amyloid growth induced by heterologous fibrils.
The Journal of biological chemistry 2004;279(17):17490-9.
2002: Songming Chen; Valerie Berthelier; J Bradley Hamilton; Brian O'Nuallain; Ronald B. Wetzel
Amyloid-like features of polyglutamine aggregates and their assembly kinetics.
Biochemistry 2002;41(23):7391-9.
2002: Brian O'Nuallain; Ronald B. Wetzel
Conformational Abs recognizing a generic amyloid fibril epitope.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1485-90.