FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ghislain Opdenakker

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Leukocyte Chemotaxis

Co-author Network

Publications

TOP 3
Christian R Frey; Wanchi Fung; Romas Geleziunas; Bin Han; Magdeleine Hung; Xiaohong Liu; Ghislain Opdenakker; Robert Snoeck; Ivan Votruba; Graciela Andrei; Carina Cannizzaro; Pierre Fiten; Tomas Cihlar
Mutations in Adenosine Deaminase-like (ADAL) Protein Confer Resistance to the Antiproliferative Agents N6-Cyclopropyl-PMEDAP and GS-9219.
Ahmed M Abu El-Asrar; Gert De Hertogh; Mohd I Nawaz; Mohammad S Ola; Ghislain Opdenakker; Karel Geboes
Expression of thrombospondin-2 as a marker in proliferative diabetic retinopathy.
Katrien Deroost; Chris J Janse; Mina Komuta; Natacha Lays; Jing-Wen Lin; Sam Noppen; Ghislain Opdenakker; Ana Pamplona; Mauro Prato; Tania Roskams; Evelin Schwarzer; Ariane Tyberghein; Paolo Arese; Dirk Daelemans; Els Vanstreels; Philippe E Van den Steen
Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ghislain Opdenakker (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Christian R Frey; Wanchi Fung; Romas Geleziunas; Bin Han; Magdeleine Hung; Xiaohong Liu; Ghislain Opdenakker; Robert Snoeck; Ivan Votruba; Graciela Andrei; Carina Cannizzaro; Pierre Fiten; Tomas Cihlar
Mutations in Adenosine Deaminase-like (ADAL) Protein Confer Resistance to the Antiproliferative Agents N6-Cyclopropyl-PMEDAP and GS-9219.
Anticancer research 2013;33(5):1899-912.
2013: Ahmed M Abu El-Asrar; Gert De Hertogh; Mohd I Nawaz; Mohammad S Ola; Ghislain Opdenakker; Karel Geboes
Expression of thrombospondin-2 as a marker in proliferative diabetic retinopathy.
Acta ophthalmologica 2013;91(3):e169-77.
2013: Katrien Deroost; Chris J Janse; Mina Komuta; Natacha Lays; Jing-Wen Lin; Sam Noppen; Ghislain Opdenakker; Ana Pamplona; Mauro Prato; Tania Roskams; Evelin Schwarzer; Ariane Tyberghein; Paolo Arese; Dirk Daelemans; Els Vanstreels; Philippe E Van den Steen
Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.
American journal of respiratory cell and molecular biology 2013;48(5):589-600.
2013: Graciela Andrei; Michel Aoun; Pierre Fiten; Aspasia Georgala; Ghislain Opdenakker; Dimitri Topalis; Robert Snoeck
Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.
The Journal of infectious diseases 2013;207(8):1295-305.
2013: Jennifer Vandooren; Philippe E Van den Steen; Nathalie Geurts; Erik Martens; Ghislain Opdenakker
Zymography methods for visualizing hydrolytic enzymes.
Nature methods 2013;10(3):211-20.
2013: Katrin Kierdorf; Bruno Luckow; Dominik N Müller; Ghislain Opdenakker; Elisa Gomez Perdiguero; Pia Riemke; Frank Rosenbauer; Victor Sander; Christian Schulz; Peter Wieghofer; Knut Biber; Thomas Brocker; Katharina Debowski; Andreas Diefenbach; Daniel Erny; Günter Fritz; Frederic Geissmann; Tobias Goldmann; Mathias Heikenwalder; Annette Heinrich; Christoph Hölscher; Marco Prinz
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Nature neuroscience 2013;16(3):273-80.
2013: Vanessa De Vooght; Steven Haenen; Peter H M Hoet; Benoit Nemery; Ghislain Opdenakker; Stijn Smulders; Jochen Belmans; Erik Verbeken; Jeroen A J Vanoirbeek
Neutrophil and eosinophil granulocytes as key players in a mouse model of chemical-induced asthma.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):406-18.
2012: Nathalie Geurts; Erik Martens; Paul Proost; Walter Stöcker; Philippe E Van den Steen; Christoph Becker-Pauly; Ghislain Opdenakker
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
FEBS letters 2012;586(24):4264-9.
2012: Diego Sbardella; Francesca Sciandra; Philippe E Van den Steen; Andrea Brancaccio; Massimo Castagnola; Massimo Coletta; Bruno Giardina; Magda Gioia; Federica Iavarone; Rosanna Inzitari; Stefano Marini; Ghislain Opdenakker; Manuela Bozzi
Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan.
IUBMB life 2012;64(12):988-94.
2012: Gustaf Christoffersson; Majken Lidén; Sara Massena; Ghislain Opdenakker; Alvin C Powers; Rachel B Reinert; Evelina Vågesjö; Jennifer Vandooren; Marcela Brissova; Mia Phillipson
VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue.
Blood 2012;120(23):4653-62.
2012: Helene Piccard; Lydia Sorokin; Ilse Van Aelst; Nele Berghmans; Jo Van Damme; Chris Dillen; Eva Korpos; Sandra Li; Sandra Liekens; Erik Martens; Sam Noppen; Ghislain Opdenakker
Glycosaminoglycan mimicry by COAM reduces melanoma growth through chemokine induction and function.
International journal of cancer. Journal international du cancer 2012;131(4):E425-36.
2012: Ahmed M Abu El-Asrar; Saleh A Al-Obeidan; Karel Geboes; Dustan Kangave; Ghislain Opdenakker; Sofie Struyf; Jo Van Damme
Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis.
Cytokine 2012;59(2):377-81.
2012: Zheng Qiu; Philippe E Van den Steen; Jialiang Hu; Ghislain Opdenakker
Targeting matrix metalloproteinases in acute inflammatory shock syndromes.
Combinatorial chemistry & high throughput screening 2012;15(7):555-70.
2012: Zheng Qiu; Philippe E Van den Steen; Min Wang; Ming Yan; Qian Li; Datao Liu; Ghislain Opdenakker; Jialiang Hu
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-α converting enzyme (TACE/ADAM-17).
Journal of enzyme inhibition and medicinal chemistry 2012;27(4):533-40.
2012: Helene Piccard; R J Muschel; Ghislain Opdenakker
On the dual roles and polarized phenotypes of neutrophils in tumor development and progression.
Critical reviews in oncology/hematology 2012;82(3):296-309.
2012: Sandra Liekens; Beatrice Nico; Ghislain Opdenakker; María-Jesús Pérez-Pérez; Jan Balzarini; Mirella Belleri; Annelies Bronckaers; Antonella Bugatti; Elena Casanova; Alba Gigante; Domenico Ribatti; Rebecca Sienaert; Marco Presta
The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist.
Molecular cancer therapeutics 2012;11(4):817-29.
2012: Graciela Andrei; Jan Balzarini; Pierre Fiten; Christopher McGuigan; Ghislain Opdenakker; D Topalis; Robert Snoeck
In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.
Journal of virology 2012;86(5):2641-52.
2012: Nathalie Geurts; Ghislain Opdenakker; Philippe E Van den Steen
Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections.
Pharmacology & therapeutics 2012;133(3):257-79.
2012: Nele Berghmans; Hubertine Heremans; Sandra Li; Erik Martens; Patrick Matthys; Lydia Sorokin; Jo Van Damme; Ghislain Opdenakker
Rescue from acute neuroinflammation by pharmacological chemokine-mediated deviation of leukocytes.
Journal of neuroinflammation 2012;9():243.
2012: Katrien Deroost; Natacha Lays; Erik Martens; Sam Noppen; Ghislain Opdenakker; Philippe E Van den Steen
Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.
Malaria journal 2012;11():166.
2011: Lara Garabedian; Ghislain Opdenakker; Silvano Sozzani; Sofie Struyf; Jo Van Damme; Geneviève Laureys
Langerhans cell histiocytosis: a cytokine/chemokine-mediated disorder?
European cytokine network 2011;22(3):148-53.
2011: Stijn E Verleden; Robin Vos; Stijn Willems; Jennifer Vandooren; Geert M Verleden; Lieven J Dupont; Ghislain Opdenakker; Dirk E Van Raemdonck; Bart M Vanaudenaerde
Azithromycin decreases MMP-9 expression in the airways of lung transplant recipients.
Transplant immunology 2011;25(2-3):159-62.
2011: Mauro Prato; Donatella Taramelli; Philippe E Van den Steen; Paolo Arese; Sarah D'Alessandro; Ghislain Opdenakker; Nicoletta Basilico
Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.
Cellular microbiology 2011;13(8):1275-85.
2011: Nele Berghmans; Amber Nuyts; Ghislain Opdenakker; Catherine Uyttenhove; Jacques Van Snick; Hubertine Heremans
Interferon-γ orchestrates the number and function of Th17 cells in experimental autoimmune encephalomyelitis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(7):575-87.
2011: Catherine Uyttenhove; Reece G Marillier; Fabienne Tacchini-Cottier; Mélanie Charmoy; Rachel R Caspi; Jesse M Damsker; Stanislas Goriely; Dan Su; Jo Van Damme; Sofie Struyf; Ghislain Opdenakker; Jacques Van Snick
Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection.
Journal of leukocyte biology 2011;89(6):1001-7.
2011: Bénédicte Cauwe; Erik Martens; Xavier Sagaert; Chris Dillen; Nathalie Geurts; Sandra Li; Jan Mertens; Greet Thijs; Philippe E Van den Steen; Hubertine Heremans; Rita De Vos; Daniel Blockmans; Bernd Arnold; Ghislain Opdenakker
Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease.
Journal of autoimmunity 2011;36(3-4):239-52.
2011: Ahmed M Abu El-Asrar; Sofie Struyf; Dustan Kangave; Saleh S Al-Obeidan; Ghislain Opdenakker; Karel Geboes; Jo Van Damme
Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.
Clinical immunology (Orlando, Fla.) 2011;139(2):177-84.
2011: Hannelien Verbeke; Sofie Struyf; Nele Berghmans; Els Van Coillie; Ghislain Opdenakker; Catherine Uyttenhove; Jacques Van Snick; Jo Van Damme
Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis.
Cancer letters 2011;302(1):54-62.
2011: Jennifer Vandooren; Nathalie Geurts; Erik Martens; Philippe E Van den Steen; Steven De Jonghe; Piet Herdewijn; Ghislain Opdenakker
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.
World journal of biological chemistry 2011;2(1):14-24.
2011: Sofie Struyf; Laura Salogni; Marie D Burdick; Jo Vandercappellen; Mieke Gouwy; Sam Noppen; Paul Proost; Ghislain Opdenakker; Marc Parmentier; Craig Gerard; Silvano Sozzani; Robert M Strieter; Jo Van Damme
Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.
Blood 2011;117(2):480-8.
2011: Nathalie Geurts; Hubertine Heremans; Natacha Lays; Sandra Li; Stefan Magez; Erik Martens; Ghislain Opdenakker; Greet Thijs; Bénédicte Cauwe; Sebastien Verhenne; Philippe E Van den Steen
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.
PloS one 2011;6(11):e27131.
2010: Sandra Li; Sofie Starckx; Erik Martens; Chris Dillen; Nathalie Lamerant-Fayel; Nele Berghmans; Mieke Gouwy; Melissa van Pel; Hubertine Heremans; Claudine Kieda; Willem E Fibbe; Alfons Billiau; Jo Van Damme; Ghislain Opdenakker
Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection.
Journal of leukocyte biology 2010;88(5):1017-29.
2010: Jan De Munck; Atsushi Mine; Philippe E Van den Steen; Kirsten Van Landuyt; André Poitevin; Ghislain Opdenakker; Bart Van Meerbeek
Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives.
European journal of oral sciences 2010;118(5):494-501.
2010: Bénédicte Cauwe; Ghislain Opdenakker
Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.
Critical reviews in biochemistry and molecular biology 2010;45(5):351-423.
2010: Hannelien Verbeke; Gert De Hertogh; Sandra Li; Jo Vandercappellen; Samuel Noppen; Evemie Schutyser; Ahmed Abu El-Asrar; Ghislain Opdenakker; Jo Van Damme; Karel Geboes; Sofie Struyf
Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer.
Human pathology 2010;41(7):990-1001.
2010: Philippe E Van den Steen; Nathalie Geurts; Katrien Deroost; Ilse Van Aelst; Sebastien Verhenne; Hubertine Heremans; Jo Van Damme; Ghislain Opdenakker
Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2010;181(9):957-68.
2010: Javier Redondo-Muñoz; Estefanía Ugarte-Berzal; María José Terol; Philippe E Van den Steen; Mercedes Hernández del Cerro; Martin Roderfeld; Elke Roeb; Ghislain Opdenakker; José A García-Marco; Angeles García-Pardo
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.
Cancer cell 2010;17(2):160-72.
2010: Ahmed M Abu El-Asrar; Sofie Struyf; Ghislain Opdenakker; Jo Van Damme; Karel Geboes
Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes.
Molecular vision 2010;16():1098-107.
2010: Gabriel Rosenblum; Philippe E Van den Steen; Sidney R Cohen; Arkady Bitler; David Douglass Brand; Ghislain Opdenakker; Irit Sagi
Direct visualization of protease action on collagen triple helical structure.
PloS one 2010;5(6):e11043.
2009: Tamara Loos; Ghislain Opdenakker; Jo Van Damme; Paul Proost
Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.
Haematologica 2009;94(10):1346-53.
2009: Elzbieta Kolaczkowska; Agnieszka Koziol; Barbara Plytycz; Bernd Arnold; Ghislain Opdenakker
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.
Immunology letters 2009;126(1-2):73-82.
2009: Veronica C Ardi; Philippe E Van den Steen; Ghislain Opdenakker; Bernhard Schweighofer; Elena I Deryugina; James P Quigley
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
The Journal of biological chemistry 2009;284(38):25854-66.
2009: Mieke Gouwy; Sofie Struyf; Hannelien Verbeke; Willy Put; Paul Proost; Ghislain Opdenakker; Jo Van Damme
CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8.
Journal of leukocyte biology 2009;86(3):671-80.
2009: Elzbieta Kolaczkowska; Barbara Plytycz; Bernd Arnold; Helene Piccard; Ghislain Opdenakker
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
Immunology 2009;128(1 Suppl):e262-74.
2009: Kyung-Pil Park; Anna Rosell; Christian Foerch; Changhong Xing; Woo Jean Kim; Seoul Lee; Ghislain Opdenakker; Karen L Furie; Eng H Lo
Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats.
Stroke; a journal of cerebral circulation 2009;40(8):2836-42.
2009: Helene Piccard; Jialiang Hu; Pierre Fiten; Paul Proost; Erik Martens; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker
"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products.
Electrophoresis 2009;30(13):2366-77.
2009: Bénédicte Cauwe; Erik Martens; Paul Proost; Ghislain Opdenakker
Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates.
Integrative biology : quantitative biosciences from nano to macro 2009;1(5-6):404-26.
2009: Armando M De Palma; Hendrik J Thibaut; Sandra Li; Ilse Van Aelst; Chris Dillen; Melissa Swinnen; Erik Verbeken; Johan Neyts; Ghislain Opdenakker
Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis.
The Journal of pathology 2009;217(5):633-41.
2009: Sofie Struyf; Paul Proost; Jo Vandercappellen; Sebastian Dempe; Becky Noyens; Sofie Nelissen; Mieke Gouwy; Massimo Locati; Ghislain Opdenakker; Christiane Dinsart; Jo Van Damme
Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects.
European journal of immunology 2009;39(3):843-57.
2009: Elzbieta Kolaczkowska; Weronika Grzybek; Nico van Rooijen; Helene Piccard; Barbara Plytycz; Bernd Arnold; Ghislain Opdenakker
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.
Journal of leukocyte biology 2009;85(3):374-81.
2009: Magda Gioia; Susanna Monaco; Philippe E Van den Steen; Diego Sbardella; Giuseppe Grasso; Stefano Marini; Christopher M Overall; Ghislain Opdenakker; Massimo Coletta
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.
Journal of molecular biology 2009;386(2):419-34.
2009: Zheng Qiu; Chris Dillen; Jialiang Hu; Hannelien Verbeke; Sofie Struyf; Jo Van Damme; Ghislain Opdenakker
Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes.
Immunobiology 2009;214(9-10):835-42.
2008: Armando M De Palma; Erik Verbeken; Ilse Van Aelst; Philippe E Van den Steen; Ghislain Opdenakker; Johan Neyts
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
Virology 2008;382(1):20-7.
2008: Don B Gammon; Robert Snoeck; Pierre Fiten; Marcela Krecmerová; Antonín Holý; Erik De Clercq; Ghislain Opdenakker; David H Evans; Graciela Andrei
Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs.
Journal of virology 2008;82(24):12520-34.
2008: Francis J Descamps; Dustan Kangave; B Cauwe; Erik Martens; Karel Geboes; Ahmed M Abu El-Asrar; Ghislain Opdenakker
Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions.
Journal of cellular and molecular medicine 2008;12(6A):2449-56.
2008: Sandra Li; Erik Martens; Chris Dillen; Philippe E Van den Steen; Ghislain Opdenakker
Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).
Biochemical pharmacology 2008;76(7):831-40.
2008: Bénédicte Cauwe; Ellen Martens; Philippe E Van den Steen; Paul Proost; Ilse Van Aelst; Daniel Blockmans; Ghislain Opdenakker
Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.
Experimental cell research 2008;314(15):2739-49.
2008: Paul Proost; Tamara Loos; Anneleen Mortier; Evemie Schutyser; Mieke Gouwy; Samuel Noppen; Chris Dillen; Isabelle Ronsse; René Conings; Sofie Struyf; Ghislain Opdenakker; Prabhat C Maudgal; Jo Van Damme
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
The Journal of experimental medicine 2008;205(9):2085-97.
2008: Javier Redondo-Muñoz; Estefanía Ugarte-Berzal; José A García-Marco; Mercedes Hernández del Cerro; Philippe E Van den Steen; Ghislain Opdenakker; María José Terol; Angeles García-Pardo
Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.
Blood 2008;112(1):169-78.
2008: Philippe E Van den Steen; Katrien Deroost; Ilse Van Aelst; Nathalie Geurts; Erik Martens; Sofie Struyf; Catherine Q Nie; Diana Hansen; Patrick Matthys; Jo Van Damme; Ghislain Opdenakker
CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.
European journal of immunology 2008;38(4):1082-95.
2008: Nathalie Geurts; Erik Martens; Ilse Van Aelst; Paul Proost; Ghislain Opdenakker; Philippe E Van den Steen
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.
Biochemistry 2008;47(8):2689-99.
2008: Elzbieta Kolaczkowska; Bernd Arnold; Ghislain Opdenakker
Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils.
Immunobiology 2008;213(2):109-24.
2008: Philip J Bergin; Sukanya Raghavan; Helena Svensson; Sofie Starckx; Ilse Van Aelst; Inger Gjertsson; Ghislain Opdenakker; Marianne Quiding-Järbrink
Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis.
FEMS immunology and medical microbiology 2008;52(1):88-98.
2007: Jo Vandercappellen; Samuel Noppen; Hannelien Verbeke; Willy Put; René Conings; Mieke Gouwy; Evemie Schutyser; Paul Proost; Raf Sciot; Karel Geboes; Ghislain Opdenakker; Jo Van Damme; Sofie Struyf
Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells.
Journal of leukocyte biology 2007;82(6):1519-30.
2007: Gabriel Rosenblum; Philippe E Van den Steen; Sidney R Cohen; J Günter Grossmann; Jessica Frenkel; Rotem Sertchook; Nelle L Slack; Richard W Strange; Ghislain Opdenakker; Irit Sagi
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.
Structure (London, England : 1993) 2007;15(10):1227-36.
2007: Ahmed M Abu El-Asrar; Sofie Struyf; Ghislain Opdenakker; Karel Geboes; Jo Van Damme
The role of chemokines and their receptors in uveitis.
International ophthalmology 2007;27(5):321-7.
2007: Jialiang Hu; Philippe E Van den Steen; Qing-Xiang A Sang; Ghislain Opdenakker
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.
Nature reviews. Drug discovery 2007;6(6):480-98.
2007: Graciela Andrei; Pierre Fiten; Patrick Goubau; HW Van Landuyt; Bart Gordts; Dominik Selleslag; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck
Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society 2007;9(2):126-31.
2007: Bénédicte Cauwe; Philippe E Van den Steen; Ghislain Opdenakker
The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.
Critical reviews in biochemistry and molecular biology 2007;42(3):113-85.
2007: Xuedong Fan; Andriani C Patera; Amy Pong-Kennedy; Gregory Deno; Waldemar Gonsiorek; Denise Manfra; Galya Vassileva; Ming Zeng; Craig Jackson; Lee Sullivan; Wanda Sharif-Rodriguez; Ghislain Opdenakker; Jo Van Damme; Joseph A Hedrick; Daniel Lundell; sergio lira; R William Hipkin
Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.
The Journal of biological chemistry 2007;282(16):11658-66.
2007: Helene Piccard; Philippe E Van den Steen; Ghislain Opdenakker
Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.
Journal of leukocyte biology 2007;81(4):870-92.
2007: Ahmed M Abu El-Asrar; Philippe E Van den Steen; Saleh A Al-Amro; Luc Missotten; Ghislain Opdenakker; Karel Geboes
Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders.
International ophthalmology 2007;27(1):11-22.
2007: Erik Martens; An Leyssen; Ilse Van Aelst; Pierre Fiten; Helene Piccard; Jialiang Hu; Francis J Descamps; Philippe E Van den Steen; Paul Proost; Jo Van Damme; Grazia Maria Liuzzi; Paolo Riccio; Eugenia Polverini; Ghislain Opdenakker
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Biochimica et biophysica acta 2007;1770(2):178-86.
2007: Gracíela Andrei; Pierre Fiten; Matheus Froeyen; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Antiviral therapy 2007;12(5):719-32.
2007: Mineo Iwata; Manoj Pillai; Aravind Ramakrishnan; Robert C Hackman; Ghislain Opdenakker; H Joachim Deeg; Beverly Torok-Storb
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.
Blood 2007;109(1):85-92.
2006: Simon A Fry; Philippe E Van den Steen; Louise Royle; Mark R Wormald; Anthony J Leathem; Ghislain Opdenakker; James M McDonnell; Raymond A Dwek; Pauline M Rudd
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.
Biochemistry 2006;45(51):15249-58.
2006: Graciela Andrei; Don B Gammon; Pierre Fiten; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck; David H Evans
Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice.
Journal of virology 2006;80(19):9391-401.
2006: Jialiang Hu; Véronique Dubois; Patrick Chaltin; Pierre Fiten; Chris Dillen; Philippe E Van den Steen; Ghislain Opdenakker
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.
Combinatorial chemistry & high throughput screening 2006;9(8):599-611.
2006: Philippe E Van den Steen; Ilse Van Aelst; Sofie Starckx; Klaus Maskos; Ghislain Opdenakker; Axel Pagenstecher
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):873-88.
2006: Tamara Loos; Lies Dekeyzer; Sofie Struyf; Evemie Schutyser; Klara Gijsbers; Mieke Gouwy; Annelies Fraeyman; Willy Put; Isabelle Ronsse; Bernard Grillet; Ghislain Opdenakker; Jo Van Damme; Paul Proost
TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):902-16.
2006: Véronique Winnepenninckx; Maria Debiec-Rychter; Jeroen A M Beliën; Pierre Fiten; Stefan Michiels; Vladimir Lazar; Ghislain Opdenakker; Gerrit A Meijer; Alain Spatz; Joost J van den Oord
Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(9):1170-80.
2006: Francis J Descamps; Erik Martens; Dustan Kangave; Sofie Struyf; Karel Geboes; Jo Van Damme; Ghislain Opdenakker; Ahmed M Abu El-Asrar
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage.
Experimental eye research 2006;83(2):401-7.
2006: Philippe E Van den Steen; Ilse Van Aelst; Vibeke Hvidberg; Helene Piccard; Pierre Fiten; Christian Jacobsen; Søren K Moestrup; Simon Fry; Louise Royle; Mark R Wormald; Russell Wallis; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
2006: Elzbieta Kolaczkowska; Anna Scislowska-Czarnecka; Magdalena Chadzinska; Barbara Plytycz; Nico van Rooijen; Ghislain Opdenakker; Bernd Arnold
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.
Journal of leukocyte biology 2006;80(1):125-32.
2006: Ann-Marie Calander; Sofie Starckx; Ghislain Opdenakker; Philip Bergin; Marianne Quiding-Järbrink; Andrej Tarkowski
Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis.
Microbes and infection / Institut Pasteur 2006;8(6):1434-9.
2006: Smriti Agrawal; Per Anderson; Madeleine Durbeej; Nico van Rooijen; Fredrik Ivars; Ghislain Opdenakker; Lydia Sorokin
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2006;203(4):1007-19.
2006: Ghislain Opdenakker; Chris Dillen; Pierre Fiten; Erik Martens; Ilse Van Aelst; Philippe E Van den Steen; Inge Nelissen; Sofie Starckx; Francis J Descamps; Jialiang Hu; Helene Piccard; Jo Van Damme; Mark R Wormald; Pauline M Rudd; Raymond A Dwek
Remnant epitopes, autoimmunity and glycosylation.
Biochimica et biophysica acta 2006;1760(4):610-5.
2006: Inge Nelissen; Djordje Gveric; Johannes M van Noort; M Louise Cuzner; Ghislain Opdenakker
PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions.
Neuropathology and applied neurobiology 2006;32(1):15-22.
2006: Paul Proost; Sofie Struyf; Tamara Loos; Mieke Gouwy; Evemie Schutyser; René Conings; Isabelle Ronsse; Marc Parmentier; Bernard Grillet; Ghislain Opdenakker; Jan Balzarini; Jo Van Damme
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies.
Arthritis research & therapy 2006;8(4):R107.
2006: Elzbieta Kolaczkowska; Magdalena Chadzinska; Anna Scislowska-Czarnecka; Barbara Plytycz; Ghislain Opdenakker; Bernd Arnold
Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis.
Immunobiology 2006;211(3):137-48.
2005: Karel Geboes; Paul Rutgeerts; Ghislain Opdenakker; Allan Olson; Kamlesh Patel; Carrie L Wagner; Colleen W Marano
Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease.
Current medical research and opinion 2005;21(11):1741-54.
2005: Graciela Andrei; Joost J van den Oord; Pierre Fiten; Ghislain Opdenakker; Christiane De Wolf-Peeters; Erik De Clercq; Robert Snoeck
Organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses.
Antimicrobial agents and chemotherapy 2005;49(11):4671-80.
2005: Jialiang Hu; Philippe E Van den Steen; Chris Dillen; Ghislain Opdenakker
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.
Biochemical pharmacology 2005;70(4):535-44.
2005: Ghislain Opdenakker
Immunohistopathology to guide multiple sclerosis treatment.
Lancet 2005;366(9485):526-7.
2005: Sofie Struyf; Mieke Gouwy; Chris Dillen; Paul Proost; Ghislain Opdenakker; Jo Van Damme
Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue.
European journal of immunology 2005;35(5):1583-91.
2005: Graciela Andrei; Jan Balzarini; Pierre Fiten; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.
Journal of virology 2005;79(9):5863-9.
2005: Jialiang Hu; Pierre Fiten; Philippe E Van den Steen; Patrick Chaltin; Ghislain Opdenakker
Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.
Analytical chemistry 2005;77(7):2116-24.
2005: Milla Koistinaho; Tarja M Malm; Mikko I Kettunen; Gundars Goldsteins; Sofie Starckx; Risto A Kauppinen; Ghislain Opdenakker; Jari Koistinaho
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(4):460-7.
2005: Maarten Dewil; Céline Schurmans; Sofie Starckx; Ghislain Opdenakker; Ludo Van Den Bosch; Wim Robberecht
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis.
Neuroreport 2005;16(4):321-4.
2005: Klara Gijsbers; Mieke Gouwy; Sofie Struyf; Anja Wuyts; Paul Proost; Ghislain Opdenakker; Freddy Penninckx; Nadine Ectors; Karel Geboes; Jo Van Damme
GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors.
Experimental cell research 2005;303(2):331-42.
2005: Simon A Fry; Philippe E Van den Steen; Louise Royle; Mark R Wormald; Anthony J Leathem; Ghislain Opdenakker; Pauline M Rudd; Raymond A Dwek
Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.
Advances in experimental medicine and biology 2005;564():103-12.
2005: Philippe E Van den Steen; Bernard Grillet; Ghislain Opdenakker
Gelatinase B participates in collagen II degradation and releases glycosylated remnant epitopes in rheumatoid arthritis.
Advances in experimental medicine and biology 2005;564():45-55.
2005: Francis J Descamps; Erik Martens; Paul Proost; Sofie Starckx; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker
Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):29-35.
2004: Francis J Descamps; Erik Martens; Florence Ballaux; Karel Geboes; Ghislain Opdenakker
In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes.
The Journal of pathology 2004;204(5):555-61.
2004: Iakov Shimanovich; Sidonia Mihai; Gertie J Oostingh; T Toney Ilenchuk; Eva-B Bröcker; Ghislain Opdenakker; Detlef Zillikens; Cassian Sitaru
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
The Journal of pathology 2004;204(5):519-27.
2004: Ahmed M Abu El-Asrar; Sofie Struyf; Francis J Descamps; Saleh A Al-Obeidan; Paul Proost; Jo Van Damme; Ghislain Opdenakker; Karel Geboes
Chemokines and gelatinases in the aqueous humor of patients with active uveitis.
American journal of ophthalmology 2004;138(3):401-11.
2004: Philippe E Van den Steen; Paul Proost; David Douglass Brand; Andrew H Kang; Jo Van Damme; Ghislain Opdenakker
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.
Biochemistry 2004;43(33):10809-16.
2004: Jo Van Damme; Sofie Struyf; Ghislain Opdenakker
Chemokine-protease interactions in cancer.
Seminars in cancer biology 2004;14(3):201-8.
2004: Paul Proost; Sara Verpoest; Kirsten Van de Borne; Evemie Schutyser; Sofie Struyf; Willy Put; Isabelle Ronsse; Bernard Grillet; Ghislain Opdenakker; Jo Van Damme
Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids.
Journal of leukocyte biology 2004;75(5):777-84.
2004: Jialiang Hu; Philippe E Van den Steen; Michel Houde; T Toney Ilenchuk; Ghislain Opdenakker
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody.
Biochemical pharmacology 2004;67(5):1001-9.
2004: Ghislain Opdenakker; Jo Van Damme
The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines.
The International journal of developmental biology 2004;48(5-6):519-27.
2004: Gerjo A Velders; Ronald van Os; Henny Hagoort; Perry Verzaal; Henri F L Guiot; Ivan J D Lindley; Rein Willemze; Ghislain Opdenakker; Willem E Fibbe
Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization.
Blood 2004;103(1):340-6.
2003: Peter H Larsen; Jennifer Elizabeth Ann Larsen; William B Stallcup; Ghislain Opdenakker; V Wee Yong
Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(35):11127-35.
2003: Ghislain Opdenakker; Inge Nelissen; Jo Van Damme
Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis.
Lancet neurology 2003;2(12):747-56.
2003: Paul Proost; An-Katrien Vynckier; Frank Mahieu; Willy Put; Bernard Grillet; Sofie Struyf; Anja Wuyts; Ghislain Opdenakker; Jo Van Damme
Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis.
European journal of immunology 2003;33(11):3146-53.
2003: Sofie Struyf; Evemie Schutyser; Mieke Gouwy; Klara Gijsbers; Paul Proost; Yves Benoit; Ghislain Opdenakker; Jo Van Damme; Geneviève Laureys
PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia.
The American journal of pathology 2003;163(5):2065-75.
2003: Philippe E Van den Steen; Steven J Husson; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.
Biochemical and biophysical research communications 2003;310(3):889-96.
2003: Bénédicte Dubois; Siobhan M Leary; Inge Nelissen; Ghislain Opdenakker; Gavin Giovannoni; Alan J Thompson
Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a.
Journal of neurology 2003;250(9):1037-43.
2003: Philippe E Van den Steen; Anja Wuyts; Steven J Husson; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.
European journal of biochemistry / FEBS 2003;270(18):3739-49.
2003: Sofie Starckx; Philippe E Van den Steen; Richard Verbeek; Johannes M van Noort; Ghislain Opdenakker
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
Journal of neuroimmunology 2003;141(1-2):47-57.
2003: Inge Nelissen; Erik Martens; Philippe E Van den Steen; Paul Proost; Isabelle Ronsse; Ghislain Opdenakker
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy.
Brain : a journal of neurology 2003;126(Pt 6):1371-81.
2003: Francis J Descamps; Philippe E Van den Steen; Erik Martens; Florence Ballaux; Karel Geboes; Ghislain Opdenakker
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):887-9.
2003: Ghislain Opdenakker; Philippe E Van den Steen; Geneviève Laureys; Kathleen Hunninck; Bernd Arnold
Neutralizing antibodies in gene-defective hosts.
Trends in immunology 2003;24(2):94-100.
2003: Francis J Descamps; Philippe E Van den Steen; Inge Nelissen; Jo Van Damme; Ghislain Opdenakker
Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes.
Advances in experimental medicine and biology 2003;535():69-77.
2003: Anja Wuyts; Sofie Struyf; Klara Gijsbers; Evemie Schutyser; Willy Put; René Conings; Jean-Pierre Lenaerts; Karel Geboes; Ghislain Opdenakker; Patricia Menten; Paul Proost; Jo Van Damme
The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8.
Laboratory investigation; a journal of technical methods and pathology 2003;83(1):23-34.
2002: Philippe E Van den Steen; Bénédicte Dubois; Inge Nelissen; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).
Critical reviews in biochemistry and molecular biology 2002;37(6):375-536.
2002: Francis J Descamps; Erik Martens; Ghislain Opdenakker
Analysis of gelatinases in complex biological fluids and tissue extracts.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1607-8.
2002: Sofie Starckx; Anja Wuyts; Inge Opsomer; Els Van Coillie; Paul Proost; Bernd Arnold; Jo Van Damme; Ghislain Opdenakker
Recombinant mouse granulocyte chemotactic protein-2: production in bacteria, characterization, and systemic effects on leukocytes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):965-74.
2002: Inge Nelissen; Bénédicte Dubois; An Goris; Isabelle Ronsse; Herwig Carton; Ghislain Opdenakker
Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis.
Journal of the neurological sciences 2002;200(1-2):43-8.
2002: Bénédicte Dubois; Sofie Starckx; Axel Pagenstecher; Joost van den Oord; Bernd Arnold; Ghislain Opdenakker
Gelatinase B deficiency protects against endotoxin shock.
European journal of immunology 2002;32(8):2163-71.
2002: Ruth Tachezy; Annabel Rector; Marta Havelkova; Elke Wollants; Pierre Fiten; Ghislain Opdenakker; Bennett Jenson; John Sundberg; Marc Van Ranst
Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus.
BMC microbiology 2002;2():19.
2002: Evemie Schutyser; Sofie Struyf; Paul Proost; Ghislain Opdenakker; Geneviève Laureys; Bruno Verhasselt; Lieven Peperstraete; Ignace Van de Putte; Alessandra Saccani; Paola Allavena; Alberto Mantovani; Jo Van Damme
Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma.
The Journal of biological chemistry 2002;277(27):24584-93.
2002: Johannes F M Pruijt; Perry Verzaal; Ronald van Os; Evert-Jan F M de Kruijf; Marianke L J van Schie; Alberto Mantovani; Annunciata Vecchi; Ivan J D Lindley; Rein Willemze; Sofie Starckx; Ghislain Opdenakker; Willem E Fibbe
Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6228-33.
2002: Koen Vandenbroeck; Pierre Fiten; Shirley Heggarty; An Goris; Eleonora Cocco; Stanley A Hawkins; Colin A Graham; Maria Giovanna Marrosu; Ghislain Opdenakker
Chromosome 7q21-22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene.
Journal of neuroimmunology 2002;125(1-2):141-8.
2002: Philippe E Van den Steen; Paul Proost; Bernard Grillet; David Douglass Brand; Andrew H Kang; Jo Van Damme; Ghislain Opdenakker
Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):379-89.
2002: Sofie Starckx; Philippe E Van den Steen; Anja Wuyts; Jo Van Damme; Ghislain Opdenakker
Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.
Leukemia & lymphoma 2002;43(2):233-41.
2002: Inge Nelissen; Isabelle Ronsse; Jo Van Damme; Ghislain Opdenakker
Regulation of gelatinase B in human monocytic and endothelial cells by PECAM-1 ligation and its modulation by interferon-beta.
Journal of leukocyte biology 2002;71(1):89-98.
2001: Paul Proost; Evemie Schutyser; Patricia Menten; Sofie Struyf; Anja Wuyts; Ghislain Opdenakker; Michel detheux; Marc Parmentier; Christine Durinx; Anne-Marie Lambeir; J Neyts; Sandra Liekens; P C Maudgal; An D Billiau; Jo Van Damme
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties.
Blood 2001;98(13):3554-61.
2001: Evemie Schutyser; Sofie Struyf; Anja Wuyts; Willy Put; Karel Geboes; Bernard Grillet; Ghislain Opdenakker; Jo Van Damme
Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis.
European journal of immunology 2001;31(12):3755-62.
2001: Philippe E Van den Steen; Ghislain Opdenakker; Mark R Wormald; R A Dwek; P M Rudd
Matrix remodelling enzymes, the protease cascade and glycosylation.
Biochimica et biophysica acta 2001;1528(2-3):61-73.
2001: Sofie Struyf; G Stoops; Els Van Coillie; Mieke Gouwy; Evemie Schutyser; Jean-Pierre Lenaerts; Pierre Fiten; Ilse Van Aelst; Paul Proost; Ghislain Opdenakker; Jo Van Damme
Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants.
Biochemistry 2001;40(39):11715-22.
2001: Els Van Coillie; Ilse Van Aelst; Anja Wuyts; R Vercauteren; R Devos; Christiane De Wolf-Peeters; Jo Van Damme; Ghislain Opdenakker
Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle.
The American journal of pathology 2001;159(4):1405-14.
2001: Ghislain Opdenakker; Philippe E Van den Steen; J Van Damme
Gelatinase B: a tuner and amplifier of immune functions.
Trends in immunology 2001;22(10):571-9.
2001: Graciela Andrei; P Fiten; Erik De Clercq; Robert Snoeck; Ghislain Opdenakker
Evaluating phenotype and genotype of drug-resistant strains in herpesviruses.
Molecular biotechnology 2001;18(2):155-67.
2001: Ghislain Opdenakker; Philippe E Van den Steen; Bénédicte Dubois; Inge Nelissen; Els Van Coillie; S Masure; Paul Proost; Jo Van Damme
Gelatinase B functions as regulator and effector in leukocyte biology.
Journal of leukocyte biology 2001;69(6):851-9.
2000: Taj S Mattu; Louise Royle; J Langridge; Mark R Wormald; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker; David Harvey; Raymond A Dwek; Pauline M Rudd
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
Biochemistry 2000;39(51):15695-704.
2000: Koen Vandenbroeck; An Goris; A Billiau; Ghislain Opdenakker; Cornelia Hardt
Interferon gamma gene in rheumatoid arthritis.
Lancet 2000;356(9248):2191-2.
2000: Anja Wuyts; Evemie Schutyser; Patricia Menten; Sofie Struyf; A D'Haese; Hidde Bult; Ghislain Opdenakker; Paul Proost; Jo Van Damme
Biochemical and biological characterization of neutrophil chemotactic protein, a novel rabbit CXC chemokine from alveolar macrophages.
Biochemistry 2000;39(47):14549-57.
2000: Oded Kleifeld; Philippe E Van den Steen; Anatoly I Frenkel; F Cheng; H L Jiang; Ghislain Opdenakker; Irit Sagi
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.
The Journal of biological chemistry 2000;275(44):34335-43.
2000: Philippe E Van den Steen; Paul Proost; Anja Wuyts; Jo Van Damme; Ghislain Opdenakker
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
Blood 2000;96(8):2673-81.
2000: Koen Vandenbroeck; Pierre Fiten; Isabelle Ronsse; An Goris; I Porru; Cristina Melis; Marcella Rolesu; An D Billiau; Maria Giovanna Marrosu; Ghislain Opdenakker
High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease.
Genes and immunity 2000;1(7):460-3.
2000: Inge Nelissen; Pierre Fiten; Koen Vandenbroeck; Jan Hillert; Tomas Olsson; Maria Giovanna Marrosu; Ghislain Opdenakker
PECAM1, MPO and PRKAR1A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia.
Journal of neuroimmunology 2000;108(1-2):153-9.
2000: A D'Haese; Anja Wuyts; Chris Dillen; B Dubois; An D Billiau; Hubertine Heremans; Jo Van Damme; Bernd Arnold; Ghislain Opdenakker
In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(7):667-74.
2000: Inge Nelissen; Koen Vandenbroeck; Pierre Fiten; Jan Hillert; Tomas Olsson; Maria Giovanna Marrosu; Ghislain Opdenakker
Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis.
Journal of neuroimmunology 2000;105(1):58-63.
2000: Graciela Andrei; Pierre Fiten; Erik De Clercq; Robert Snoeck; Ghislain Opdenakker
Monitoring drug resistance for herpesviruses.
Methods in molecular medicine 2000;24():151-69.
2000: Koen Vandenbroeck; Cornelia Hardt; J Louage; Pierre Fiten; S Jäckel; Isabelle Ronsse; Jörg T Epplen; Luigi M E Grimaldi; Tomas Olsson; Maria Giovanna Marrosu; An D Billiau; Ghislain Opdenakker
Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, northern Italy, Sardinia and Sweden.
Genes and immunity 2000;1(4):290-2.
2000: Willem E Fibbe; Johannes F M Pruijt; Yvette van Kooyk; Carl G Figdor; Ghislain Opdenakker; Rein Willemze
The role of metalloproteinases and adhesion molecules in interleukin-8-induced stem-cell mobilization.
Seminars in hematology 2000;37(1 Suppl 2):19-24.
1999: Bénédicte Dubois; S Masure; U Hurtenbach; L Paemen; Hubertine Heremans; Joost J van den Oord; R Sciot; T Meinhardt; G Hämmerling; Ghislain Opdenakker; Bernd Arnold
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.
The Journal of clinical investigation 1999;104(11):1507-15.
1999: Pauline M Rudd; Taj S Mattu; S Masure; T Bratt; Philippe E Van den Steen; Mark R Wormald; B Küster; David Harvey; Niels Borregaard; Jo Van Damme; Raymond A Dwek; Ghislain Opdenakker
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
Biochemistry 1999;38(42):13937-50.
1999: JL Pype; Lieven J Dupont; Patricia Menten; Els Van Coillie; Ghislain Opdenakker; Jo Van Damme; K F Chung; Maurits G Demedts; Geert M Verleden
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines.
American journal of respiratory cell and molecular biology 1999;21(4):528-36.
1999: Johannes F M Pruijt; Willem E Fibbe; Laurens Laterveer; R A Pieters; Ivan J D Lindley; L Paemen; S Masure; Rein Willemze; Ghislain Opdenakker
Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10863-8.
1999: An Goris; C Epplen; Pierre Fiten; M Andersson; Raffaele Murru; Francesca L Sciacca; Isabelle Ronsse; S Jäckel; Jörg T Epplen; Maria Giovanna Marrosu; Tomas Olsson; Luigi M E Grimaldi; Ghislain Opdenakker; An D Billiau; Koen Vandenbroeck
Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(9):1037-46.
1999: Els Van Coillie; Ilse Van Aelst; Pierre Fiten; An D Billiau; Jo Van Damme; Ghislain Opdenakker
Transcriptional control of the human MCP-2 gene promoter by IFN-gamma and IL-1beta in connective tissue cells.
Journal of leukocyte biology 1999;66(3):502-11.
1999: Grazia Maria Liuzzi; MP Santacroce; W J Peumans; E J Van Damme; B Dubois; Ghislain Opdenakker; Paolo Riccio
Regulation of gelatinases in microglia and astrocyte cell cultures by plant lectins.
Glia 1999;27(1):53-61.
1999: Willem E Fibbe; Johannes F M Pruijt; Gerjo A Velders; Ghislain Opdenakker; Yvette van Kooyk; Carl G Figdor; Rein Willemze
Biology of IL-8-induced stem cell mobilization.
Annals of the New York Academy of Sciences 1999;872():71-82.
1999: Sofie Struyf; Paul Proost; Dominique Schols; Erik De Clercq; Ghislain Opdenakker; Jean-Pierre Lenaerts; Michel detheux; Marc Parmentier; Ingrid De Meester; Simon Scharpé; Jo Van Damme
CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4903-9.
1999: Els Van Coillie; Jo Van Damme; Ghislain Opdenakker
The MCP/eotaxin subfamily of CC chemokines.
Cytokine & growth factor reviews 1999;10(1):61-86.
1999: Pierre Fiten; Koen Vandenbroeck; Bénédicte Dubois; Els Van Coillie; Inge Nelissen; Jo Van Damme; Arturs Ligers; Jan Hillert; M Andersson; Tomas Olsson; Ghislain Opdenakker
Microsatellite polymorphisms in the gene promoter of monocyte chemotactic protein-3 and analysis of the association between monocyte chemotactic protein-3 alleles and multiple sclerosis development.
Journal of neuroimmunology 1999;95(1-2):195-201.
1999: B Dubois; Ghislain Opdenakker; H Carton
Gelatinase B in multiple sclerosis and experimental autoimmune encephalomyelitis.
Acta neurologica Belgica 1999;99(1):53-6.
1999: Paul Proost; Sofie Struyf; Dominique Schols; Ghislain Opdenakker; S Sozzani; Paola Allavena; Alberto Mantovani; Koen Augustyns; Gunther Bal; Achiel Haemers; Anne-Marie Lambeir; Simon Scharpé; Jo Van Damme; Ingrid De Meester
Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.
The Journal of biological chemistry 1999;274(7):3988-93.
1999: M Louise Cuzner; Ghislain Opdenakker
Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.
Journal of neuroimmunology 1999;94(1-2):1-14.
1999: Patricia Menten; Paul Proost; Sofie Struyf; Els Van Coillie; Willy Put; Jean-Pierre Lenaerts; René Conings; JM Jaspar; DD De Groote; An D Billiau; Ghislain Opdenakker; Jo Van Damme
Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and interferon-gamma reveals MCP-3 heterogeneity.
European journal of immunology 1999;29(2):678-85.
1999: Pauline M Rudd; Taj S Mattu; Nicole Zitzmann; A Mehta; Cristina Colominas; Edmund Hart; Ghislain Opdenakker; Raymond A Dwek
Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans.
Biotechnology & genetic engineering reviews 1999;16():1-21.
1999: Koen Vandenbroeck; An Goris; Raffaele Murru; An D Billiau; Ghislain Opdenakker; Maria Giovanna Marrosu
A dinucleotide repeat polymorphism located in the IFN-alpha/beta gene cluster at chromosome 9p22 is not associated with multiple sclerosis in Sardinia.
Experimental and clinical immunogenetics 1999;16(1):26-9.
1998: Philippe E Van den Steen; Pauline M Rudd; Paul Proost; Erik Martens; L Paemen; B Küster; Jo Van Damme; Raymond A Dwek; Ghislain Opdenakker
Oligosaccharides of recombinant mouse gelatinase B variants.
Biochimica et biophysica acta 1998;1425(3):587-98.
1998: Els Van Coillie; Paul Proost; Ilse Van Aelst; Sofie Struyf; M Polfliet; Ingrid De Meester; David Harvey; Jo Van Damme; Ghislain Opdenakker
Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.
Biochemistry 1998;37(36):12672-80.
1998: Daniel Anthony; Karen M Miller; S Fearn; MJ Townsend; Ghislain Opdenakker; Graham M A Wells; John M Clements; Stephen Chandler; AJ Gearing; V Hugh Perry
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.
Journal of neuroimmunology 1998;87(1-2):62-72.
1998: Ahmed M Abu El-Asrar; Lieve Dralands; M Veckeneer; Karel Geboes; Luc Missotten; I Van Aelst; Ghislain Opdenakker
Gelatinase B in proliferative vitreoretinal disorders.
American journal of ophthalmology 1998;125(6):844-51.
1998: B Dubois; Willy J Peumans; Els J M Van Damme; Jo Van Damme; Ghislain Opdenakker
Regulation of gelatinase B (MMP-9) in leukocytes by plant lectins.
FEBS letters 1998;427(2):275-8.
1998: Bénédicte Dubois; Marie B D'hooghe; K De Lepeleire; Pierre Ketelaer; Ghislain Opdenakker; Herwig Carton
Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 1998;4(2):74-8.
1998: Ghislain Opdenakker; W E Fibbe; Jo Van Damme
The molecular basis of leukocytosis.
Immunology today 1998;19(4):182-9.
1998: Paul Proost; Ingrid De Meester; Dominique Schols; Sofie Struyf; Anne-Marie Lambeir; Anja Wuyts; Ghislain Opdenakker; Erik De Clercq; Simon Scharpé; Jo Van Damme
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
The Journal of biological chemistry 1998;273(13):7222-7.
1998: Sofie Struyf; E Van Collie; L Paemen; Willy Put; Jean-Pierre Lenaerts; Paul Proost; Ghislain Opdenakker; Jo Van Damme
Synergistic induction of MCP-1 and -2 by IL-1beta and interferons in fibroblasts and epithelial cells.
Journal of leukocyte biology 1998;63(3):364-72.
1998: Philippe E Van den Steen; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
Concepts and principles of O-linked glycosylation.
Critical reviews in biochemistry and molecular biology 1998;33(3):151-208.
1998: Philippe E Van den Steen; Pauline M Rudd; Raymond A Dwek; Jo Van Damme; Ghislain Opdenakker
Cytokine and protease glycosylation as a regulatory mechanism in inflammation and autoimmunity.
Advances in experimental medicine and biology 1998;435():133-43.
1997: Jo Van Damme; Anja Wuyts; Guy Froyen; Els Van Coillie; Sofie Struyf; An D Billiau; Paul Proost; J M Wang; Ghislain Opdenakker
Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage.
Journal of leukocyte biology 1997;62(5):563-9.
1997: N Zhou; L Paemen; Ghislain Opdenakker; Guy Froyen
Cloning and expression in Escherichia coli of a human gelatinase B-inhibitory single-chain immunoglobulin variable fragment (scFv).
FEBS letters 1997;414(3):562-6.
1997: Kunio Hieshima; Teruko Imai; M Baba; Kiyomitsu Shoudai; K Ishizuka; T Nakagawa; Junji Tsuruta; M Takeya; Y Sakaki; K Takatsuki; Retsu Miura; Ghislain Opdenakker; J Van Damme; Osamu Yoshie; Hisayuki Nomiyama
A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1140-9.
1997: Bernard Grillet; J Dequeker; L Paemen; B Van Damme; Ghislain Opdenakker
Gelatinase B in chronic synovitis: immunolocalization with a monoclonal antibody.
British journal of rheumatology 1997;36(7):744-7.
1997: L Paemen; PM Jansen; Paul Proost; Jo Van Damme; Ghislain Opdenakker; Erik Hack; Fletcher B Taylor
Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia.
Cytokine 1997;9(6):412-5.
1997: Els Van Coillie; Pierre Fiten; Hisayuki Nomiyama; Y Sakaki; Retsu Miura; O Yoshie; Jo Van Damme; Ghislain Opdenakker
The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.
Genomics 1997;40(2):323-31.
1997: Kunio Hieshima; Teruko Imai; Ghislain Opdenakker; J Van Damme; Jun Kusuda; H Tei; Y Sakaki; K Takatsuki; Retsu Miura; Osamu Yoshie; Hisayuki Nomiyama
Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.
The Journal of biological chemistry 1997;272(9):5846-53.
1997: Els Van Coillie; Guy Froyen; Hisayuki Nomiyama; Retsu Miura; Pierre Fiten; Ilse Van Aelst; Jo Van Damme; Ghislain Opdenakker
Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.
Biochemical and biophysical research communications 1997;231(3):726-30.
1997: S Masure; L Paemen; Ilse Van Aelst; Pierre Fiten; Paul Proost; An D Billiau; Jo Van Damme; Ghislain Opdenakker
Production and characterization of recombinant active mouse gelatinase B from eukaryotic cells and in vivo effects after intravenous administration.
European journal of biochemistry / FEBS 1997;244(1):21-30.
1997: Guy Froyen; Paul Proost; Isabelle Ronsse; Tania Mitera; Annemie Haelens; Anja Wuyts; Ghislain Opdenakker; Jo Van Damme; An D Billiau
Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs.
European journal of biochemistry / FEBS 1997;243(3):762-9.
1997: K Murakami; Hisayuki Nomiyama; Retsu Miura; A Follens; Pierre Fiten; Els Van Coillie; J Van Damme; Ghislain Opdenakker
Structural and functional analysis of the promoter region of the human MCP-3 gene: transactivation of expression by novel recognition sequences adjacent to the transcription initiation site.
DNA and cell biology 1997;16(2):173-83.
1997: Jo Van Damme; Sofie Struyf; Anja Wuyts; Ghislain Opdenakker; Paul Proost; Paola Allavena; S Sozzani; A Mantovani
Isolation of human monocyte chemotactic proteins and study of their producer and responder cells by immunotests and bioassays.
Methods in enzymology 1997;287():109-27.
1997: Anja Wuyts; Paul Proost; Guy Froyen; Annemie Haelens; An D Billiau; Ghislain Opdenakker; Jo Van Damme
Purification and identification of human and mouse granulocyte chemotactic protein-2 isoforms.
Methods in enzymology 1997;287():13-33.
1996: Yves St-Pierre; M Desrosiers; P Tremblay; P O Estève; Ghislain Opdenakker
Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres.
Cytometry 1996;25(4):374-80.
1996: Annemie Haelens; Anja Wuyts; Paul Proost; Sofie Struyf; Ghislain Opdenakker; Jo Van Damme
Leukocyte migration and activation by murine chemokines.
Immunobiology 1996;195(4-5):499-521.
1996: Anja Wuyts; Annemie Haelens; Paul Proost; Jean-Pierre Lenaerts; René Conings; Ghislain Opdenakker; Jo Van Damme
Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1736-43.
1996: L Paemen; E Martens; K Norga; S Masure; E Roets; J Hoogmartens; Ghislain Opdenakker
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.
Biochemical pharmacology 1996;52(1):105-11.
1996: K Naruse; M Ueno; T Satoh; Hisayuki Nomiyama; H Tei; M Takeda; David Ledbetter; E V Coillie; Ghislain Opdenakker; N Gunge; Y Sakaki; M Iio; Retsu Miura
A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2.
Genomics 1996;34(2):236-40.
1996: E Hoeben; Ilse Van Aelst; Johannes V Swinnen; Ghislain Opdenakker; Guido Verhoeven
Gelatinase A secretion and its control in peritubular and Sertoli cell cultures: effects of hormones, second messengers and inducers of cytokine production.
Molecular and cellular endocrinology 1996;118(1-2):37-46.
1996: M Houde; P Tremblay; S Masure; Ghislain Opdenakker; D Oth; R Mandeville
Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator.
Biochimica et biophysica acta 1996;1310(2):193-200.
1996: K Norga; B Grillet; S Masure; L Paemen; Ghislain Opdenakker
Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: anti-rheumatic activity by protease inhibition.
Clinical rheumatology 1996;15(1):31-4.
1995: L Paemen; E Martens; S Masure; Ghislain Opdenakker
Monoclonal antibodies specific for natural human neutrophil gelatinase B used for affinity purification, quantitation by two-site ELISA and inhibition of enzymatic activity.
European journal of biochemistry / FEBS 1995;234(3):759-65.
1995: S Masure; L Paemen; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(11):955-63.
1995: Pauline M Rudd; Robert J Woods; Mark R Wormald; Ghislain Opdenakker; A Kristina Downing; Iain D Campbell; Raymond A Dwek
The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.
Biochimica et biophysica acta 1995;1248(1):1-10.
1995: K Mori; Raymond A Dwek; A Kristina Downing; Ghislain Opdenakker; Pauline M Rudd
The activation of type 1 and type 2 plasminogen by type I and type II tissue plasminogen activator.
The Journal of biological chemistry 1995;270(7):3261-7.
1995: Paul Proost; P Van Leuven; Anja Wuyts; R Ebberink; Ghislain Opdenakker; Jo Van Damme
Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines.
Cytokine 1995;7(2):97-104.
1995: E Van Cutsem; Robert Snoeck; Marc Van Ranst; Pierre Fiten; Ghislain Opdenakker; K Geboes; J Janssens; P Rutgeerts; G Vantrappen; E de Clercq
Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine.
Journal of medical virology 1995;45(2):230-5.
1995: P Tremblay; M Houde; Nathalie Arbour; D Rochefort; S Masure; R Mandeville; Ghislain Opdenakker; D Oth
Differential effects of PKC inhibitors on gelatinase B and interleukin 6 production in the mouse macrophage.
Cytokine 1995;7(2):130-6.
1995: Jozef Anne; Pierre Fiten; Lieve Van Mellaert; B Joris; Ghislain Opdenakker; H Eyssen
Analysis of the open reading frames of the main capsid proteins of actinophage VWB.
Archives of virology 1995;140(6):1033-47.
1994: Koen Vandenbroeck; L Willems; An D Billiau; Ghislain Opdenakker; Roger Huybrechts
Glycoform heterogeneity of porcine interferon-gamma expressed in Sf9 cells.
Lymphokine and cytokine research 1994;13(4):253-8.
1994: S Thirion; G Nys; Pierre Fiten; S Masure; Jo Van Damme; Ghislain Opdenakker
Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC.
Biochemical and biophysical research communications 1994;201(2):493-9.
1994: Jo Van Damme; Paul Proost; Willy Put; S Arens; Jean-Pierre Lenaerts; René Conings; Ghislain Opdenakker; Hubertine Heremans; An D Billiau
Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers. Chemical synthesis of MCP-2 and development of a specific RIA.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5495-502.
1994: Ghislain Opdenakker; Pierre Fiten; G Nys; Guy Froyen; Nadine Van Roy; Frank Speleman; Geneviève Laureys; Jo Van Damme
The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.
Genomics 1994;21(2):403-8.
1994: Pauline M Rudd; H C Joao; E Coghill; P Fiten; M R Saunders; Ghislain Opdenakker; Raymond A Dwek
Glycoforms modify the dynamic stability and functional activity of an enzyme.
Biochemistry 1994;33(1):17-22.
1994: Koen Vandenbroeck; Pierre Fiten; Ghislain Opdenakker; An D Billiau
Two distinct interleukin-1 beta genes in the pig genome.
Immunogenetics 1994;40(1):82.
1993: S Masure; G Nys; Pierre Fiten; Jo Van Damme; Ghislain Opdenakker
Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation.
European journal of biochemistry / FEBS 1993;218(1):129-41.
1993: K Gijbels; Paul Proost; S Masure; Herwig Carton; An D Billiau; Ghislain Opdenakker
Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein.
Journal of neuroscience research 1993;36(4):432-40.
1993: Koen Vandenbroeck; Pierre Fiten; E Beuken; E Martens; A Janssen; Jo Van Damme; Ghislain Opdenakker; An D Billiau
Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta.
European journal of biochemistry / FEBS 1993;217(1):45-52.
1993: Paul Proost; Anja Wuyts; René Conings; Jean-Pierre Lenaerts; An D Billiau; Ghislain Opdenakker; Jo Van Damme
Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines.
Biochemistry 1993;32(38):10170-7.
1993: Paul Proost; Jo Van Damme; Ghislain Opdenakker
Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein.
Biochemical and biophysical research communications 1993;192(3):1175-81.
1993: Ghislain Opdenakker; Guy Froyen; Pierre Fiten; Paul Proost; Jo Van Damme
Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.
Biochemical and biophysical research communications 1993;191(2):535-42.
1993: M Houde; Georges de Bruyne; Marc Bracke; M Ingelman-Sundberg; G Skoglund; S Masure; J van Damme; Ghislain Opdenakker
Differential regulation of gelatinase B and tissue-type plasminogen activator expression in human Bowes melanoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):395-400.
1993: Paul Proost; C De Wolf-Peeters; René Conings; Ghislain Opdenakker; An D Billiau; Jo Van Damme
Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):1000-10.
1993: Jo Van Damme; Paul Proost; Jean-Pierre Lenaerts; René Conings; Ghislain Opdenakker; An D Billiau
Monocyte chemotactic proteins related to human MCP-1.
Advances in experimental medicine and biology 1993;351():111-8.
1992: K Gijbels; S Masure; Herwig Carton; Ghislain Opdenakker
Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders.
Journal of neuroimmunology 1992;41(1):29-34.
1992: Marc Van Ranst; Akira Fuse; Pierre Fiten; E Beuken; Herbert Pfister; Robert D Burk; Ghislain Opdenakker
Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations.
Virology 1992;190(2):587-96.
1992: Akira Fuse; B Simizu; Marc Van Ranst; Ghislain Opdenakker; Jo Van Damme
The induction of IL-6 and gelatinase B by IL-1 in mouse cell lines transformed with bovine papillomavirus: decreased production in tumorigenic cells.
Lymphokine and cytokine research 1992;11(4):215-20.
1992: Jo Van Damme; Paul Proost; Jean-Pierre Lenaerts; Ghislain Opdenakker
Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.
The Journal of experimental medicine 1992;176(1):59-65.
1992: Ghislain Opdenakker; J Van Damme
Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.
Cytokine 1992;4(4):251-8.
1991: Ghislain Opdenakker; S Masure; B Grillet; Jo Van Damme
Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.
Lymphokine and cytokine research 1991;10(4):317-24.
1991: F Vandekerckhove; Ghislain Opdenakker; Marc Van Ranst; Jean-Pierre Lenaerts; Willy Put; An D Billiau; Jo Van Damme
Bradykinin induces interleukin-6 and synergizes with interleukin-1.
Lymphokine and cytokine research 1991;10(4):285-9.
1991: Marc Van Ranst; Akira Fuse; H Sobis; W De Meurichy; S M Syrjänen; An D Billiau; Ghislain Opdenakker
A papillomavirus related to HPV type 13 in oral focal epithelial hyperplasia in the pygmy chimpanzee.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1991;20(7):325-31.
1991: Jo Van Damme; B Decock; R Bertini; René Conings; Jean-Pierre Lenaerts; Willy Put; Ghislain Opdenakker; A Mantovani
Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene.
European journal of biochemistry / FEBS 1991;199(1):223-9.
1991: Ghislain Opdenakker; S Masure; Paul Proost; An D Billiau; Jo Van Damme
Natural human monocyte gelatinase and its inhibitor.
FEBS letters 1991;284(1):73-8.
1991: S Masure; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8.
European journal of biochemistry / FEBS 1991;198(2):391-8.
1991: Marc Van Ranst; K Norga; S Masure; Paul Proost; F Vandekerckhove; Johan Auwerx; Jo Van Damme; Ghislain Opdenakker
The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.
Cytokine 1991;3(3):231-9.
1990: S Masure; An D Billiau; Jo Van Damme; Ghislain Opdenakker
Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate.
Biochimica et biophysica acta 1990;1054(3):317-25.
1990: Jo Van Damme; R A Bunning; René Conings; R Graham; G Russell; Ghislain Opdenakker
Characterization of granulocyte chemotactic activity from human cytokine-stimulated chondrocytes as interleukin 8.
Cytokine 1990;2(2):106-11.
1990: Y Cabeza-Arvelaiz; Chris Dillen; Hubertine Heremans; Jo Van Damme; J Cailleau; An D Billiau; Ghislain Opdenakker
Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems.
Lymphokine research 1990;9(2):125-35.
1989: R B Parekh; Raymond A Dwek; J R Thomas; Ghislain Opdenakker; T W Rademacher; A J Wittwer; Carol Howard; R Nelson; N R Siegel; M G Jennings
Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator.
Biochemistry 1989;28(19):7644-62.
1989: Jo Van Damme; B Decock; René Conings; Jean-Pierre Lenaerts; Ghislain Opdenakker; An D Billiau
The chemotactic activity for granulocytes produced by virally infected fibroblasts is identical to monocyte-derived interleukin 8.
European journal of immunology 1989;19(7):1189-94.
1989: S Masure; Ghislain Opdenakker
Cytokine-mediated proteolysis in tissue remodelling.
Experientia 1989;45(6):542-9.
1989: Ghislain Opdenakker; Y Cabeza-Arvelaiz; Jo Van Damme
Interaction of interferon with other cytokines.
Experientia 1989;45(6):513-20.
1989: Jo Van Damme; M R Schaafsma; W E Fibbe; J H Falkenburg; Ghislain Opdenakker; An D Billiau
Simultaneous production of interleukin 6, interferon-beta and colony-stimulating activity by fibroblasts after viral and bacterial infection.
European journal of immunology 1989;19(1):163-8.
1988: Ghislain Opdenakker; F Bosman; B Decock; Y Cabeza-Arvelaiz; Jo Van Damme; An D Billiau
Heterogeneity of human tissue-type plasminogen activator.
FEBS letters 1988;238(1):129-34.
1988: Jo Van Damme; J Van Beeumen; Ghislain Opdenakker; An D Billiau
A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity.
The Journal of experimental medicine 1988;167(4):1364-76.