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Ghislain Opdenakker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
95
Van Damme, Jo
59
Proost, Paul
47
Van den Steen, Philippe
36
Fiten, Pierre
32
Struyf, Sofie
29
Billiau, An
22
Masure, S
21
Wuyts, Anja
15
Dwek, Raymond
14
Van Coillie, Els
14
Martens, Erik
14
Rudd, Pauline
13
Van Aelst, Ilse
13
Conings, René
13
Geboes, Karel

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Publications

TOP 3
Loos Tamara; Opdenakker Ghislain; Van Damme Jo; Proost Paul
Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.
Kolaczkowska Elzbieta; Koziol Agnieszka; Plytycz Barbara; Arnold Bernd; Opdenakker Ghislain
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.
Ardi Veronica C; Van den Steen Philippe E; Opdenakker Ghislain; Schweighofer Bernhard; Deryugina Elena I; Quigley James P
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

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All Publications

2009: Loos Tamara; Opdenakker Ghislain; Van Damme Jo; Proost Paul
Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.
Haematologica 2009;94(10):1346-53.
2009: Kolaczkowska Elzbieta; Koziol Agnieszka; Plytycz Barbara; Arnold Bernd; Opdenakker Ghislain
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.
Immunology letters 2009;126(1-2):73-82.
2009: Ardi Veronica C; Van den Steen Philippe E; Opdenakker Ghislain; Schweighofer Bernhard; Deryugina Elena I; Quigley James P
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
The Journal of biological chemistry 2009;284(38):25854-66.
2009: Gouwy Mieke; Struyf Sofie; Verbeke Hannelien; Put Willy; Proost Paul; Opdenakker Ghislain; Van Damme Jo
CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8.
Journal of leukocyte biology 2009;86(3):671-80.
2009: Kolaczkowska Elzbieta; Plytycz Barbara; Arnold Bernd; Piccard Helene; Opdenakker Ghislain
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
Immunology 2009;128(1 Suppl):e262-74.
2009: Park Kyung-Pil; Rosell Anna; Foerch Christian; Xing Changhong; Kim Woo Jean; Lee Seoul; Opdenakker Ghislain; Furie Karen L; Lo Eng H
Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats.
Stroke; a journal of cerebral circulation 2009;40(8):2836-42.
2009: Piccard Helene; Hu Jialiang; Fiten Pierre; Proost Paul; Martens Erik; Van den Steen Philippe E; Van Damme Jo; Opdenakker Ghislain
"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products.
Electrophoresis 2009;30(13):2366-77.
2009: De Palma Armando M; Thibaut Hendrik J; Li Sandra; Van Aelst Ilse; Dillen Chris; Swinnen Melissa; Verbeken Erik; Neyts Johan; Opdenakker Ghislain
Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4-induced pancreatitis.
The Journal of pathology 2009;217(5):633-41.
2009: Struyf Sofie; Proost Paul; Vandercappellen Jo; Dempe Sebastian; Noyens Becky; Nelissen Sofie; Gouwy Mieke; Locati Massimo; Opdenakker Ghislain; Dinsart Christiane; Van Damme Jo
Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects.
European journal of immunology 2009;39(3):843-57.
2009: Kolaczkowska Elzbieta; Grzybek Weronika; van Rooijen Nico; Piccard Helene; Plytycz Barbara; Arnold Bernd; Opdenakker Ghislain
Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis.
Journal of leukocyte biology 2009;85(3):374-81.
2009: Gioia Magda; Monaco Susanna; Van Den Steen Philippe E; Sbardella Diego; Grasso Giuseppe; Marini Stefano; Overall Christopher M; Opdenakker Ghislain; Coletta Massimo
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.
Journal of molecular biology 2009;386(2):419-34.
2009: Qiu Zheng; Dillen Chris; Hu Jialiang; Verbeke Hannelien; Struyf Sofie; Van Damme Jo; Opdenakker Ghislain
Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes.
Immunobiology 2009;214(9-10):835-42.
2008: De Palma Armando M; Verbeken Erik; Van Aelst Ilse; Van den Steen Philippe E; Opdenakker Ghislain; Neyts Johan
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
Virology 2008;382(1):20-7.
2008: Gammon Don B; Snoeck Robert; Fiten Pierre; Krecmerová Marcela; Holý Antonín; De Clercq Erik; Opdenakker Ghislain; Evans David H; Andrei Graciela
Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs.
Journal of virology 2008;82(24):12520-34.
2008: Descamps F J; Kangave D; Cauwe B; Martens E; Geboes K; Abu El-Asrar A; Opdenakker G
Interphotoreceptor retinoid-binding protein as biomarker in systemic autoimmunity with eye inflictions.
Journal of cellular and molecular medicine 2008;12(6A):2449-56.
2008: Li Sandra; Martens Erik; Dillen Chris; Van den Steen Philippe E; Opdenakker Ghislain
Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).
Biochemical pharmacology 2008;76(7):831-40.
2008: Proost Paul; Loos Tamara; Mortier Anneleen; Schutyser Evemie; Gouwy Mieke; Noppen Samuel; Dillen Chris; Ronsse Isabelle; Conings René; Struyf Sofie; Opdenakker Ghislain; Maudgal Prabhat C; Van Damme Jo
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
The Journal of experimental medicine 2008;205(9):2085-97.
2008: Cauwe Bénédicte; Martens Erik; Van den Steen Philippe E; Proost Paul; Van Aelst Ilse; Blockmans Daniel; Opdenakker Ghislain
Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.
Experimental cell research 2008;314(15):2739-49.
2008: Redondo-Muñoz Javier; Ugarte-Berzal Estefanía; García-Marco José A; del Cerro Mercedes Hernández; Van den Steen Philippe E; Opdenakker Ghislain; Terol María José; García-Pardo Angeles
Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.
Blood 2008;112(1):169-78.
2008: Van den Steen Philippe E; Deroost Katrien; Van Aelst Ilse; Geurts Nathalie; Martens Erik; Struyf Sofie; Nie Catherine Q; Hansen Diana S; Matthys Patrick; Van Damme Jo; Opdenakker Ghislain
CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.
European journal of immunology 2008;38(4):1082-95.
2008: Geurts Nathalie; Martens Erik; Van Aelst Ilse; Proost Paul; Opdenakker Ghislain; Van den Steen Philippe E
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.
Biochemistry 2008;47(8):2689-99.
2008: Bergin Philip J; Raghavan Sukanya; Svensson Helena; Starckx Sofie; Van Aelst Ilse; Gjertsson Inger; Opdenakker Ghislain; Quiding-Järbrink Marianne
Gastric gelatinase B/matrix metalloproteinase-9 is rapidly increased in Helicobacter felis-induced gastritis.
FEMS immunology and medical microbiology 2008;52(1):88-98.
2008: Kolaczkowska Elzbieta; Arnold Bernd; Opdenakker Ghislain
Gelatinase B/MMP-9 as an inflammatory marker enzyme in mouse zymosan peritonitis: comparison of phase-specific and cell-specific production by mast cells, macrophages and neutrophils.
Immunobiology 2008;213(2):109-24.
2007: Vandercappellen Jo; Noppen Samuel; Verbeke Hannelien; Put Willy; Conings René; Gouwy Mieke; Schutyser Evemie; Proost Paul; Sciot Raf; Geboes Karel; Opdenakker Ghislain; Van Damme Jo; Struyf Sofie
Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells.
Journal of leukocyte biology 2007;82(6):1519-30.
2007: Rosenblum Gabriel; Van den Steen Philippe E; Cohen Sidney R; Grossmann J Günter; Frenkel Jessica; Sertchook Rotem; Slack Nelle; Strange Richard W; Opdenakker Ghislain; Sagi Irit
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.
Structure (London, England : 1993) 2007;15(10):1227-36.
2007: Abu El-Asrar Ahmed M; Struyf Sofie; Opdenakker Ghislain; Geboes Karel; Van Damme Jo
The role of chemokines and their receptors in uveitis.
International ophthalmology 2007;27(5):321-7.
2007: Hu Jialiang; Van den Steen Philippe E; Sang Qing-Xiang A; Opdenakker Ghislain
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.
Nature reviews. Drug discovery 2007;6(6):480-98.
2007: Andrei G; Fiten P; Goubau P; van Landuyt H; Gordts B; Selleslag D; De Clercq E; Opdenakker G; Snoeck R
Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient.
Transplant infectious disease : an official journal of the Transplantation Society 2007;9(2):126-31.
2007: Cauwe Bénédicte; Van den Steen Philippe E; Opdenakker Ghislain
The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.
Critical reviews in biochemistry and molecular biology 2007;42(3):113-85.
2007: Fan Xuedong; Patera Andriani C; Pong-Kennedy Amy; Deno Gregory; Gonsiorek Waldemar; Manfra Denise J; Vassileva Galya; Zeng Ming; Jackson Craig; Sullivan Lee; Sharif-Rodriguez Wanda; Opdenakker Ghislain; Van Damme Jo; Hedrick Joseph A; Lundell Daniel; Lira Sergio A; Hipkin R William
Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8.
The Journal of biological chemistry 2007;282(16):11658-66.
2007: Piccard Helene; Van den Steen Philippe E; Opdenakker Ghislain
Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.
Journal of leukocyte biology 2007;81(4):870-92.
2007: Abu El-Asrar Ahmed M; Van den Steen Philippe E; Al-Amro Saleh A; Missotten Luc; Opdenakker Ghislain; Geboes Karel
Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders.
International ophthalmology 2007;27(1):11-22.
2007: Martens Erik; Leyssen An; Van Aelst Ilse; Fiten Pierre; Piccard Helene; Hu Jialiang; Descamps Francis J; Van den Steen Philippe E; Proost Paul; Van Damme Jo; Liuzzi Grazia Maria; Riccio Paolo; Polverini Eugenia; Opdenakker Ghislain
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Biochimica et biophysica acta 2007;1770(2):178-86.
2007: Iwata Mineo; Pillai Manoj; Ramakrishnan Aravind; Hackman Robert C; Joachim Deeg H; Opdenakker Ghislain; Torok-Storb Beverly
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.
Blood 2007;109(1):85-92.
2007: Andrei Gracíela; Fiten Pierre; Froeyen Matheus; De Clercq Erik; Opdenakker Ghislain; Snoeck Robert
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Antiviral therapy 2007;12(5):719-32.
2006: Fry Simon A; Van den Steen Philippe E; Royle Louise; Wormald Mark R; Leathem Anthony J; Opdenakker Ghislain; McDonnell James M; Dwek Raymond A; Rudd Pauline M
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.
Biochemistry 2006;45(51):15249-58.
2006: Andrei Graciela; Gammon Don B; Fiten Pierre; De Clercq Erik; Opdenakker Ghislain; Snoeck Robert; Evans David H
Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice.
Journal of virology 2006;80(19):9391-401.
2006: Hu Jialiang; Dubois Véronique; Chaltin Patrick; Fiten Pierre; Dillen Christiane; Van den Steen Philippe E; Opdenakker Ghislain
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.
Combinatorial chemistry & high throughput screening 2006;9(8):599-611.
2006: Van den Steen Philippe E; Van Aelst Ilse; Starckx Sofie; Maskos Klaus; Opdenakker Ghislain; Pagenstecher Axel
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):873-88.
2006: Loos Tamara; Dekeyzer Lies; Struyf Sofie; Schutyser Evemie; Gijsbers Klara; Gouwy Mieke; Fraeyman Annelies; Put Willy; Ronsse Isabelle; Grillet Bernard; Opdenakker Ghislain; Van Damme Jo; Proost Paul
TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):902-16.
2006: Winnepenninckx Véronique; Debiec-Rychter Maria; Beliën Jeroen A M; Fiten Pierre; Michiels Stefan; Lazar Vladimir; Opdenakker Ghislain; Meijer Gerrit A; Spatz Alain; van den Oord Joost J
Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(9):1170-80.
2006: Descamps Francis J; Martens Erik; Kangave Dustan; Struyf Sofie; Geboes Karel; Van Damme Jo; Opdenakker Ghislain; Abu El-Asrar Ahmed M
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage.
Experimental eye research 2006;83(2):401-7.
2006: Kolaczkowska Elzbieta; Scislowska-Czarnecka Anna; Chadzinska Magdalena; Plytycz Barbara; van Rooijen Nico; Opdenakker Ghislain; Arnold Bernd
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.
Journal of leukocyte biology 2006;80(1):125-32.
2006: Van den Steen Philippe E; Van Aelst Ilse; Hvidberg Vibeke; Piccard Helene; Fiten Pierre; Jacobsen Christian; Moestrup Soren K; Fry Simon; Royle Louise; Wormald Mark R; Wallis Russell; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
2006: Calander Ann-Marie; Starckx Sofie; Opdenakker Ghislain; Bergin Philip; Quiding-Järbrink Marianne; Tarkowski Andrej
Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis.
Microbes and infection / Institut Pasteur 2006;8(6):1434-9.
2006: Agrawal Smriti; Anderson Per; Durbeej Madeleine; van Rooijen Nico; Ivars Fredrik; Opdenakker Ghislain; Sorokin Lydia M
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2006;203(4):1007-19.
2006: Opdenakker Ghislain; Dillen Chris; Fiten Pierre; Martens Erik; Van Aelst Ilse; Van den Steen Philippe E; Nelissen Inge; Starckx Sofie; Descamps Francis J; Hu Jialiang; Piccard Helene; Van Damme Jo; Wormald Mark R; Rudd Pauline M; Dwek Raymond A
Remnant epitopes, autoimmunity and glycosylation.
Biochimica et biophysica acta 2006;1760(4):610-5.
2006: Nelissen I; Gveric D; van Noort J M; Cuzner M L; Opdenakker G
PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions.
Neuropathology and applied neurobiology 2006;32(1):15-22.
2006: Proost Paul; Struyf Sofie; Loos Tamara; Gouwy Mieke; Schutyser Evemie; Conings René; Ronsse Isabelle; Parmentier Marc; Grillet Bernard; Opdenakker Ghislain; Balzarini Jan; Van Damme Jo
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies.
Arthritis research & therapy 2006;8(4):R107.
2006: Kolaczkowska Elzbieta; Chadzinska Magdalena; Scislowska-Czarnecka Anna; Plytycz Barbara; Opdenakker Ghislain; Arnold Bernd
Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis.
Immunobiology 2006;211(3):137-48.
2005: Geboes Karel; Rutgeerts Paul; Opdenakker Ghislain; Olson Allan; Patel Kamlesh; Wagner Carrie L; Marano Colleen W
Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease.
Current medical research and opinion 2005;21(11):1741-54.
2005: Andrei Graciela; van den Oord Joost; Fiten Pierre; Opdenakker Ghislain; De Wolf-Peeters Chris; De Clercq Erik; Snoeck Robert
Organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses.
Antimicrobial agents and chemotherapy 2005;49(11):4671-80.
2005: Opdenakker Ghislain
Immunohistopathology to guide multiple sclerosis treatment.
Lancet 2005;366(9485):526-7.
2005: Hu Jialiang; Van den Steen Philippe E; Dillen Chris; Opdenakker Ghislain
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.
Biochemical pharmacology 2005;70(4):535-44.
2005: Struyf Sofie; Gouwy Mieke; Dillen Chris; Proost Paul; Opdenakker Ghislain; Van Damme Jo
Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue.
European journal of immunology 2005;35(5):1583-91.
2005: Andrei Graciela; Balzarini Jan; Fiten Pierre; De Clercq Erik; Opdenakker Ghislain; Snoeck Robert
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.
Journal of virology 2005;79(9):5863-9.
2005: Hu Jialiang; Fiten Pierre; Van den Steen Philippe E; Chaltin Patrick; Opdenakker Ghislain
Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.
Analytical chemistry 2005;77(7):2116-24.
2005: Koistinaho Milla; Malm Tarja M; Kettunen Mikko I; Goldsteins Gundars; Starckx Sofie; Kauppinen Risto A; Opdenakker Ghislain; Koistinaho Jari
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(4):460-7.
2005: Dewil Maarten; Schurmans Céline; Starckx Sofie; Opdenakker Ghislain; Van Den Bosch Ludo; Robberecht Wim
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis.
Neuroreport 2005;16(4):321-4.
2005: Gijsbers Klara; Gouwy Mieke; Struyf Sofie; Wuyts Anja; Proost Paul; Opdenakker Ghislain; Penninckx Freddy; Ectors Nadine; Geboes Karel; Van Damme Jo
GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors.
Experimental cell research 2005;303(2):331-42.
2005: Descamps Francis J; Martens Erik; Proost Paul; Starckx Sofie; Van den Steen Philippe E; Van Damme Jo; Opdenakker Ghislain
Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):29-35.
2005: Fry Simon A; Van den Steen Philippe E; Royle Louise; Wormald Mark R; Leathem Anthony J; Opdenakker Ghislain; Rudd Pauline M; Dwek Raymond A
Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.
Advances in experimental medicine and biology 2005;564():103-12.
2005: Van den Steen P E; Grillet B; Opdenakker G
Gelatinase B participates in collagen II degradation and releases glycosylated remnant epitopes in rheumatoid arthritis.
Advances in experimental medicine and biology 2005;564():45-55.
2004: Descamps Francis J; Martens Erik; Ballaux Florence; Geboes Karel; Opdenakker Ghislain
In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes.
The Journal of pathology 2004;204(5):555-61.
2004: Shimanovich Iakov; Mihai Sidonia; Oostingh Gertie J; Ilenchuk T Toney; Bröcker Eva-B; Opdenakker Ghislain; Zillikens Detlef; Sitaru Cassian
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
The Journal of pathology 2004;204(5):519-27.
2004: Abu El-Asrar Ahmed M; Struyf Sofie; Descamps Francis J; Al-Obeidan Saleh A; Proost Paul; Van Damme Jo; Opdenakker Ghislain; Geboes Karel
Chemokines and gelatinases in the aqueous humor of patients with active uveitis.
American journal of ophthalmology 2004;138(3):401-11.
2004: Van den Steen P E; Proost P; Brand D D; Kang A H; Van Damme J; Opdenakker G
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.
Biochemistry 2004;43(33):10809-16.
2004: Van Damme Jo; Struyf Sofie; Opdenakker Ghislain
Chemokine-protease interactions in cancer.
Seminars in cancer biology 2004;14(3):201-8.
2004: Proost Paul; Verpoest Sara; Van de Borne Kirsten; Schutyser Evemie; Struyf Sofie; Put Willy; Ronsse Isabelle; Grillet Bernard; Opdenakker Ghislain; Van Damme Jo
Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids.
Journal of leukocyte biology 2004;75(5):777-84.
2004: Hu Jialiang; Van den Steen Philippe E; Houde Michel; Ilenchuk T Toney; Opdenakker Ghislain
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody.
Biochemical pharmacology 2004;67(5):1001-9.
2004: Velders Gerjo A; van Os Ronald; Hagoort Henny; Verzaal Perry; Guiot Henri F L; Lindley Ivan J D; Willemze Roel; Opdenakker Ghislain; Fibbe Willem E
Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization.
Blood 2004;103(1):340-6.
2004: Opdenakker Ghislain; Van Damme Jo
The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines.
The International journal of developmental biology 2004;48(5-6):519-27.
2003: Larsen Peter H; Wells Jennifer E; Stallcup William B; Opdenakker Ghislain; Yong V Wee
Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(35):11127-35.
2003: Opdenakker Ghislain; Nelissen Inge; Van Damme Jo
Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosis.
Lancet neurology 2003;2(12):747-56.
2003: Proost Paul; Vynckier An-Katrien; Mahieu Frank; Put Willy; Grillet Bernard; Struyf Sofie; Wuyts Anja; Opdenakker Ghislain; Van Damme Jo
Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis.
European journal of immunology 2003;33(11):3146-53.
2003: Struyf Sofie; Schutyser Evemie; Gouwy Mieke; Gijsbers Klara; Proost Paul; Benoit Yves; Opdenakker Ghislain; Van Damme Jo; Laureys Geneviève
PARC/CCL18 is a plasma CC chemokine with increased levels in childhood acute lymphoblastic leukemia.
The American journal of pathology 2003;163(5):2065-75.
2003: Van den Steen Philippe E; Husson Steven J; Proost Paul; Van Damme Jo; Opdenakker Ghislain
Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.
Biochemical and biophysical research communications 2003;310(3):889-96.
2003: Dubois Bénédicte; Leary Siobhan M; Nelissen Inge; Opdenakker Ghislain; Giovannoni Gavin; Thompson Alan J
Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a.
Journal of neurology 2003;250(9):1037-43.
2003: Van Den Steen Philippe E; Wuyts Anja; Husson Steven J; Proost Paul; Van Damme Jo; Opdenakker Ghislain
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.
European journal of biochemistry / FEBS 2003;270(18):3739-49.
2003: Starckx Sofie; Van den Steen Philippe E; Verbeek Richard; van Noort Johannes M; Opdenakker Ghislain
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
Journal of neuroimmunology 2003;141(1-2):47-57.
2003: Nelissen Inge; Martens Erik; Van den Steen Philippe E; Proost Paul; Ronsse Isabelle; Opdenakker Ghislain
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy.
Brain : a journal of neurology 2003;126(Pt 6):1371-81.
2003: Descamps Francis J; Van den Steen Philippe E; Martens Erik; Ballaux Florence; Geboes Karel; Opdenakker Ghislain
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):887-9.
2003: Opdenakker Ghislain; Van den Steen Philippe E; Laureys Geneviève; Hunninck Kathleen; Arnold Bernd
Neutralizing antibodies in gene-defective hosts.
Trends in immunology 2003;24(2):94-100.
2003: Wuyts Anja; Struyf Sofie; Gijsbers Klara; Schutyser Evemie; Put Willy; Conings René; Lenaerts Jean-Pierre; Geboes Karel; Opdenakker Ghislain; Menten Patricia; Proost Paul; Van Damme Jo
The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8.
Laboratory investigation; a journal of technical methods and pathology 2003;83(1):23-34.
2003: Descamps Francis J; Van den Steen Philippe E; Nelissen Inge; Van Damme Jo; Opdenakker Ghislain
Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes.
Advances in experimental medicine and biology 2003;535():69-77.
2002: Van den Steen Philippe E; Dubois Bénédicte; Nelissen Inge; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).
Critical reviews in biochemistry and molecular biology 2002;37(6):375-536.
2002: Descamps Francis J; Martens Erik; Opdenakker Ghislain
Analysis of gelatinases in complex biological fluids and tissue extracts.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1607-8.
2002: Starckx Sofie; Wuyts Anja; Opsomer Inge; Van Coillie Els; Proost Paul; Arnold Bernd; Van Damme Jo; Opdenakker Ghislain
Recombinant mouse granulocyte chemotactic protein-2: production in bacteria, characterization, and systemic effects on leukocytes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(9):965-74.
2002: Dubois Bénédicte; Starckx Sofie; Pagenstecher Axel; Oord Joost van den; Arnold Bernd; Opdenakker Ghislain
Gelatinase B deficiency protects against endotoxin shock.
European journal of immunology 2002;32(8):2163-71.
2002: Nelissen I; Dubois B; Goris A; Ronsse I; Carton H; Opdenakker G
Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis.
Journal of the neurological sciences 2002;200(1-2):43-8.
2002: Tachezy Ruth; Rector Annabel; Havelkova Marta; Wollants Elke; Fiten Pierre; Opdenakker Ghislain; Jenson Bennett; Sundberg John; Van Ranst Marc
Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus.
BMC microbiology 2002;2():19.
2002: Schutyser Evemie; Struyf Sofie; Proost Paul; Opdenakker Ghislain; Laureys Genevieve; Verhasselt Bruno; Peperstraete Lieven; Van de Putte Ignace; Saccani Alessandra; Allavena Paola; Mantovani Alberto; Van Damme Jo
Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma.
The Journal of biological chemistry 2002;277(27):24584-93.
2002: Pruijt Johannes F M; Verzaal Perry; van Os Ronald; de Kruijf Evert-Jan F M; van Schie Marianke L J; Mantovani Alberto; Vecchi Annunciata; Lindley Ivan J D; Willemze Roel; Starckx Sofie; Opdenakker Ghislain; Fibbe Willem E
Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6228-33.
2002: Vandenbroeck Koen; Fiten Pierre; Heggarty Shirley; Goris An; Cocco Eleonora; Hawkins Stanley A; Graham Colin A; Marrosu Maria G; Opdenakker Ghislain
Chromosome 7q21-22 and multiple sclerosis: evidence for a genetic susceptibility effect in vicinity to the protachykinin-1 gene.
Journal of neuroimmunology 2002;125(1-2):141-8.
2002: Van den Steen Philippe E; Proost Paul; Grillet Bernard; Brand David D; Kang Andrew H; Van Damme Jo; Opdenakker Ghislain
Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):379-89.
2002: Starckx S; Van den Steen P E; Wuyts A; Van Damme J; Opdenakker G
Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.
Leukemia & lymphoma 2002;43(2):233-41.
2002: Nelissen Inge; Ronsse Isabelle; Van Damme Jo; Opdenakker Ghislain
Regulation of gelatinase B in human monocytic and endothelial cells by PECAM-1 ligation and its modulation by interferon-beta.
Journal of leukocyte biology 2002;71(1):89-98.
2001: Schutyser E; Struyf S; Wuyts A; Put W; Geboes K; Grillet B; Opdenakker G; Van Damme J
Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis.
European journal of immunology 2001;31(12):3755-62.
2001: Proost P; Schutyser E; Menten P; Struyf S; Wuyts A; Opdenakker G; Detheux M; Parmentier M; Durinx C; Lambeir A M; Neyts J; Liekens S; Maudgal P C; Billiau A; Van Damme J
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties.
Blood 2001;98(13):3554-61.
2001: Van den Steen P E; Opdenakker G; Wormald M R; Dwek R A; Rudd P M
Matrix remodelling enzymes, the protease cascade and glycosylation.
Biochimica et biophysica acta 2001;1528(2-3):61-73.
2001: Van Coillie E; Van Aelst I; Wuyts A; Vercauteren R; Devos R; De Wolf-Peeters C; Van Damme J; Opdenakker G
Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle.
The American journal of pathology 2001;159(4):1405-14.
2001: Opdenakker G; Van den Steen P E; Van Damme J
Gelatinase B: a tuner and amplifier of immune functions.
Trends in immunology 2001;22(10):571-9.
2001: Struyf S; Stoops G; Van Coillie E; Gouwy M; Schutyser E; Lenaerts J P; Fiten P; Van Aelst I; Proost P; Opdenakker G; Van Damme J
Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants.
Biochemistry 2001;40(39):11715-22.
2001: Andrei G; Fiten P; De Clercq E; Snoeck R; Opdenakker G
Evaluating phenotype and genotype of drug-resistant strains in herpesviruses.
Molecular biotechnology 2001;18(2):155-67.
2001: Opdenakker G; Van den Steen P E; Dubois B; Nelissen I; Van Coillie E; Masure S; Proost P; Van Damme J
Gelatinase B functions as regulator and effector in leukocyte biology.
Journal of leukocyte biology 2001;69(6):851-9.
2000: Vandenbroeck K; Goris A; Billiau A; Opdenakker G; Hardt C
Interferon gamma gene in rheumatoid arthritis.
Lancet 2000;356(9248):2191-2.
2000: Mattu T S; Royle L; Langridge J; Wormald M R; Van den Steen P E; Van Damme J; Opdenakker G; Harvey D J; Dwek R A; Rudd P M
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
Biochemistry 2000;39(51):15695-704.
2000: Wuyts A; Schutyser E; Menten P; Struyf S; D'Haese A; Bult H; Opdenakker G; Proost P; Van Damme J
Biochemical and biological characterization of neutrophil chemotactic protein, a novel rabbit CXC chemokine from alveolar macrophages.
Biochemistry 2000;39(47):14549-57.
2000: Kleifeld O; Van den Steen P E; Frenkel A; Cheng F; Jiang H L; Opdenakker G; Sagi I
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.
The Journal of biological chemistry 2000;275(44):34335-43.
2000: Vandenbroeck K; Fiten P; Ronsse I; Goris A; Porru I; Melis C; Rolesu M; Billiau A; Marrosu M G; Opdenakker G
High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease.
Genes and immunity 2000;1(7):460-3.
2000: Van den Steen P E; Proost P; Wuyts A; Van Damme J; Opdenakker G
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
Blood 2000;96(8):2673-81.
2000: Nelissen I; Fiten P; Vandenbroeck K; Hillert J; Olsson T; Marrosu M G; Opdenakker G
PECAM1, MPO and PRKAR1A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia.
Journal of neuroimmunology 2000;108(1-2):153-9.
2000: D'Haese A; Wuyts A; Dillen C; Dubois B; Billiau A; Heremans H; Van Damme J; Arnold B; Opdenakker G
In vivo neutrophil recruitment by granulocyte chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(7):667-74.
2000: Nelissen I; Vandenbroeck K; Fiten P; Hillert J; Olsson T; Marrosu M G; Opdenakker G
Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis.
Journal of neuroimmunology 2000;105(1):58-63.
2000: Fibbe W E; Pruijt J F; van Kooyk Y; Figdor C G; Opdenakker G; Willemze R
The role of metalloproteinases and adhesion molecules in interleukin-8-induced stem-cell mobilization.
Seminars in hematology 2000;37(1 Suppl 2):19-24.
2000: Vandenbroeck K; Hardt C; Louage J; Fiten P; Jäckel S; Ronsse I; Epplen J T; Grimaldi L M; Olsson T; Marrosu M G; Billiau A; Opdenakker G
Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, northern Italy, Sardinia and Sweden.
Genes and immunity 2000;1(4):290-2.
1999: Dubois B; Masure S; Hurtenbach U; Paemen L; Heremans H; van den Oord J; Sciot R; Meinhardt T; Hämmerling G; Opdenakker G; Arnold B
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.
The Journal of clinical investigation 1999;104(11):1507-15.
1999: Rudd P M; Mattu T S; Masure S; Bratt T; Van den Steen P E; Wormald M R; Küster B; Harvey D J; Borregaard N; Van Damme J; Dwek R A; Opdenakker G
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
Biochemistry 1999;38(42):13937-50.
1999: Pype J L; Dupont L J; Menten P; Van Coillie E; Opdenakker G; Van Damme J; Chung K F; Demedts M G; Verleden G M
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines.
American journal of respiratory cell and molecular biology 1999;21(4):528-36.
1999: Goris A; Epplen C; Fiten P; Andersson M; Murru R; Sciacca F L; Ronsse I; Jäckel S; Epplen J T; Marrosu M G; Olsson T; Grimaldi L M; Opdenakker G; Billiau A; Vandenbroeck K
Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(9):1037-46.
1999: Van Coillie E; Van Aelst I; Fiten P; Billiau A; Van Damme J; Opdenakker G
Transcriptional control of the human MCP-2 gene promoter by IFN-gamma and IL-1beta in connective tissue cells.
Journal of leukocyte biology 1999;66(3):502-11.
1999: Pruijt J F; Fibbe W E; Laterveer L; Pieters R A; Lindley I J; Paemen L; Masure S; Willemze R; Opdenakker G
Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9).
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10863-8.
1999: Liuzzi G M; Santacroce M P; Peumans W J; Van Damme E J; Dubois B; Opdenakker G; Riccio P
Regulation of gelatinases in microglia and astrocyte cell cultures by plant lectins.
Glia 1999;27(1):53-61.
1999: Fibbe W E; Pruijt J F; Velders G A; Opdenakker G; van Kooyk Y; Figdor C G; Willemze R
Biology of IL-8-induced stem cell mobilization.
Annals of the New York Academy of Sciences 1999;872():71-82.
1999: Struyf S; Proost P; Schols D; De Clercq E; Opdenakker G; Lenaerts J P; Detheux M; Parmentier M; De Meester I; Scharpé S; Van Damme J
CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4903-9.
1999: Van Coillie E; Van Damme J; Opdenakker G
The MCP/eotaxin subfamily of CC chemokines.
Cytokine & growth factor reviews 1999;10(1):61-86.
1999: Fiten P; Vandenbroeck K; Dubois B; Van Coillie E; Nelissen I; Van Damme J; Ligers A; Hillert J; Andersson M; Olsson T; Opdenakker G
Microsatellite polymorphisms in the gene promoter of monocyte chemotactic protein-3 and analysis of the association between monocyte chemotactic protein-3 alleles and multiple sclerosis development.
Journal of neuroimmunology 1999;95(1-2):195-201.
1999: Dubois B; Opdenakker G; Carton H
Gelatinase B in multiple sclerosis and experimental autoimmune encephalomyelitis.
Acta neurologica Belgica 1999;99(1):53-6.
1999: Cuzner M L; Opdenakker G
Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.
Journal of neuroimmunology 1999;94(1-2):1-14.
1999: Menten P; Proost P; Struyf S; Van Coillie E; Put W; Lenaerts J P; Conings R; Jaspar J M; De Groote D; Billiau A; Opdenakker G; Van Damme J
Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha/beta and interferon-gamma reveals MCP-3 heterogeneity.
European journal of immunology 1999;29(2):678-85.
1999: Proost P; Struyf S; Schols D; Opdenakker G; Sozzani S; Allavena P; Mantovani A; Augustyns K; Bal G; Haemers A; Lambeir A M; Scharpé S; Van Damme J; De Meester I
Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.
The Journal of biological chemistry 1999;274(7):3988-93.
1999: Rudd P M; Mattu T S; Zitzmann N; Mehta A; Colominas C; Hart E; Opdenakker G; Dwek R A
Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans.
Biotechnology & genetic engineering reviews 1999;16():1-21.
1999: Vandenbroeck K; Goris A; Murru R; Billiau A; Opdenakker G; Marrosu M G
A dinucleotide repeat polymorphism located in the IFN-alpha/beta gene cluster at chromosome 9p22 is not associated with multiple sclerosis in Sardinia.
Experimental and clinical immunogenetics 1999;16(1):26-9.
1998: Van den Steen P; Rudd P M; Proost P; Martens E; Paemen L; Küster B; van Damme J; Dwek R A; Opdenakker G
Oligosaccharides of recombinant mouse gelatinase B variants.
Biochimica et biophysica acta 1998;1425(3):587-98.
1998: Van Coillie E; Proost P; Van Aelst I; Struyf S; Polfliet M; De Meester I; Harvey D J; Van Damme J; Opdenakker G
Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26/dipeptidyl peptidase IV.
Biochemistry 1998;37(36):12672-80.
1998: Anthony D C; Miller K M; Fearn S; Townsend M J; Opdenakker G; Wells G M; Clements J M; Chandler S; Gearing A J; Perry V H
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.
Journal of neuroimmunology 1998;87(1-2):62-72.
1998: Abu El-Asrar A M; Dralands L; Veckeneer M; Geboes K; Missotten L; Van Aelst I; Opdenakker G
Gelatinase B in proliferative vitreoretinal disorders.
American journal of ophthalmology 1998;125(6):844-51.
1998: Dubois B; Peumans W J; Van Damme E J; Van Damme J; Opdenakker G
Regulation of gelatinase B (MMP-9) in leukocytes by plant lectins.
FEBS letters 1998;427(2):275-8.
1998: Dubois B; D'Hooghe M B; De Lepeleire K; Ketelaer P; Opdenakker G; Carton H
Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 1998;4(2):74-8.
1998: Opdenakker G; Fibbe W E; Van Damme J
The molecular basis of leukocytosis.
Immunology today 1998;19(4):182-9.
1998: Proost P; De Meester I; Schols D; Struyf S; Lambeir A M; Wuyts A; Opdenakker G; De Clercq E; Scharpé S; Van Damme J
Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
The Journal of biological chemistry 1998;273(13):7222-7.
1998: Struyf S; Van Collie E; Paemen L; Put W; Lenaerts J P; Proost P; Opdenakker G; Van Damme J
Synergistic induction of MCP-1 and -2 by IL-1beta and interferons in fibroblasts and epithelial cells.
Journal of leukocyte biology 1998;63(3):364-72.
1998: Van den Steen P; Rudd P M; Dwek R A; Opdenakker G
Concepts and principles of O-linked glycosylation.
Critical reviews in biochemistry and molecular biology 1998;33(3):151-208.
1998: Van den Steen P; Rudd P M; Dwek R A; Van Damme J; Opdenakker G
Cytokine and protease glycosylation as a regulatory mechanism in inflammation and autoimmunity.
Advances in experimental medicine and biology 1998;435():133-43.
1997: Van Damme J; Wuyts A; Froyen G; Van Coillie E; Struyf S; Billiau A; Proost P; Wang J M; Opdenakker G
Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage.
Journal of leukocyte biology 1997;62(5):563-9.
1997: Zhou N; Paemen L; Opdenakker G; Froyen G
Cloning and expression in Escherichia coli of a human gelatinase B-inhibitory single-chain immunoglobulin variable fragment (scFv).
FEBS letters 1997;414(3):562-6.
1997: Hieshima K; Imai T; Baba M; Shoudai K; Ishizuka K; Nakagawa T; Tsuruta J; Takeya M; Sakaki Y; Takatsuki K; Miura R; Opdenakker G; Van Damme J; Yoshie O; Nomiyama H
A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1140-9.
1997: Grillet B; Dequeker J; Paemen L; Van Damme B; Opdenakker G
Gelatinase B in chronic synovitis: immunolocalization with a monoclonal antibody.
British journal of rheumatology 1997;36(7):744-7.
1997: Paemen L; Jansen P M; Proost P; Van Damme J; Opdenakker G; Hack E; Taylor F B
Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia.
Cytokine 1997;9(6):412-5.
1997: Van Coillie E; Fiten P; Nomiyama H; Sakaki Y; Miura R; Yoshie O; Van Damme J; Opdenakker G
The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.
Genomics 1997;40(2):323-31.
1997: Van Coillie E; Froyen G; Nomiyama H; Miura R; Fiten P; Van Aelst I; Van Damme J; Opdenakker G
Human monocyte chemotactic protein-2: cDNA cloning and regulated expression of mRNA in mesenchymal cells.
Biochemical and biophysical research communications 1997;231(3):726-30.
1997: Masure S; Paemen L; Van Aelst I; Fiten P; Proost P; Billiau A; Van Damme J; Opdenakker G
Production and characterization of recombinant active mouse gelatinase B from eukaryotic cells and in vivo effects after intravenous administration.
European journal of biochemistry / FEBS 1997;244(1):21-30.
1997: Froyen G; Proost P; Ronsse I; Mitera T; Haelens A; Wuyts A; Opdenakker G; Van Damme J; Billiau A
Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs.
European journal of biochemistry / FEBS 1997;243(3):762-9.
1997: Murakami K; Nomiyama H; Miura R; Follens A; Fiten P; Van Coillie E; Van Damme J; Opdenakker G
Structural and functional analysis of the promoter region of the human MCP-3 gene: transactivation of expression by novel recognition sequences adjacent to the transcription initiation site.
DNA and cell biology 1997;16(2):173-83.
1997: Hieshima K; Imai T; Opdenakker G; Van Damme J; Kusuda J; Tei H; Sakaki Y; Takatsuki K; Miura R; Yoshie O; Nomiyama H
Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.
The Journal of biological chemistry 1997;272(9):5846-53.
1997: Van Damme J; Struyf S; Wuyts A; Opdenakker G; Proost P; Allavena P; Sozzani S; Mantovani A
Isolation of human monocyte chemotactic proteins and study of their producer and responder cells by immunotests and bioassays.
Methods in enzymology 1997;287():109-27.
1997: Wuyts A; Proost P; Froyen G; Haelens A; Billiau A; Opdenakker G; Van Damme J
Purification and identification of human and mouse granulocyte chemotactic protein-2 isoforms.
Methods in enzymology 1997;287():13-33.
1996: St-Pierre Y; Desrosiers M; Tremblay P; Estève P O; Opdenakker G
Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres.
Cytometry 1996;25(4):374-80.
1996: Haelens A; Wuyts A; Proost P; Struyf S; Opdenakker G; van Damme J
Leukocyte migration and activation by murine chemokines.
Immunobiology 1996;195(4-5):499-521.
1996: Wuyts A; Haelens A; Proost P; Lenaerts J P; Conings R; Opdenakker G; Van Damme J
Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1736-43.
1996: Paemen L; Martens E; Norga K; Masure S; Roets E; Hoogmartens J; Opdenakker G
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.
Biochemical pharmacology 1996;52(1):105-11.
1996: Naruse K; Ueno M; Satoh T; Nomiyama H; Tei H; Takeda M; Ledbetter D H; Coillie E V; Opdenakker G; Gunge N; Sakaki Y; Iio M; Miura R
A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2.
Genomics 1996;34(2):236-40.
1996: Hoeben E; Van Aelst I; Swinnen J V; Opdenakker G; Verhoeven G
Gelatinase A secretion and its control in peritubular and Sertoli cell cultures: effects of hormones, second messengers and inducers of cytokine production.
Molecular and cellular endocrinology 1996;118(1-2):37-46.
1996: Houde M; Tremblay P; Masure S; Opdenakker G; Oth D; Mandeville R
Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator.
Biochimica et biophysica acta 1996;1310(2):193-200.
1996: Norga K; Grillet B; Masure S; Paemen L; Opdenakker G
Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: anti-rheumatic activity by protease inhibition.
Clinical rheumatology 1996;15(1):31-4.
1995: Paemen L; Martens E; Masure S; Opdenakker G
Monoclonal antibodies specific for natural human neutrophil gelatinase B used for affinity purification, quantitation by two-site ELISA and inhibition of enzymatic activity.
European journal of biochemistry / FEBS 1995;234(3):759-65.
1995: Masure S; Paemen L; Proost P; Van Damme J; Opdenakker G
Expression of a human mutant monocyte chemotactic protein 3 in Pichia pastoris and characterization as an MCP-3 receptor antagonist.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(11):955-63.
1995: Rudd P M; Woods R J; Wormald M R; Opdenakker G; Downing A K; Campbell I D; Dwek R A
The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.
Biochimica et biophysica acta 1995;1248(1):1-10.
1995: Mori K; Dwek R A; Downing A K; Opdenakker G; Rudd P M
The activation of type 1 and type 2 plasminogen by type I and type II tissue plasminogen activator.
The Journal of biological chemistry 1995;270(7):3261-7.
1995: Proost P; Van Leuven P; Wuyts A; Ebberink R; Opdenakker G; Van Damme J
Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines.
Cytokine 1995;7(2):97-104.
1995: Van Cutsem E; Snoeck R; Van Ranst M; Fiten P; Opdenakker G; Geboes K; Janssens J; Rutgeerts P; Vantrappen G; de Clercq E
Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine.
Journal of medical virology 1995;45(2):230-5.
1995: Tremblay P; Houde M; Arbour N; Rochefort D; Masure S; Mandeville R; Opdenakker G; Oth D
Differential effects of PKC inhibitors on gelatinase B and interleukin 6 production in the mouse macrophage.
Cytokine 1995;7(2):130-6.
1995: Anné J; Fiten P; Van Mellaert L; Joris B; Opdenakker G; Eyssen H
Analysis of the open reading frames of the main capsid proteins of actinophage VWB.
Archives of virology 1995;140(6):1033-47.
1994: Vandenbroeck K; Willems L; Billiau A; Opdenakker G; Huybrechts R
Glycoform heterogeneity of porcine interferon-gamma expressed in Sf9 cells.
Lymphokine and cytokine research 1994;13(4):253-8.
1994: Van Damme J; Proost P; Put W; Arens S; Lenaerts J P; Conings R; Opdenakker G; Heremans H; Billiau A
Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human fibroblasts and leukocytes by cytokines and cytokine inducers. Chemical synthesis of MCP-2 and development of a specific RIA.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5495-502.
1994: Thirion S; Nys G; Fiten P; Masure S; Van Damme J; Opdenakker G
Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC.
Biochemical and biophysical research communications 1994;201(2):493-9.
1994: Opdenakker G; Fiten P; Nys G; Froyen G; Van Roy N; Speleman F; Laureys G; Van Damme J
The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.
Genomics 1994;21(2):403-8.
1994: Rudd P M; Joao H C; Coghill E; Fiten P; Saunders M R; Opdenakker G; Dwek R A
Glycoforms modify the dynamic stability and functional activity of an enzyme.
Biochemistry 1994;33(1):17-22.
1994: Vandenbroeck K; Fiten P; Opdenakker G; Billiau A
Two distinct interleukin-1 beta genes in the pig genome.
Immunogenetics 1994;40(1):82.
1993: Masure S; Nys G; Fiten P; Van Damme J; Opdenakker G
Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation.
European journal of biochemistry / FEBS 1993;218(1):129-41.
1993: Gijbels K; Proost P; Masure S; Carton H; Billiau A; Opdenakker G
Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein.
Journal of neuroscience research 1993;36(4):432-40.
1993: Vandenbroeck K; Fiten P; Beuken E; Martens E; Janssen A; Van Damme J; Opdenakker G; Billiau A
Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta.
European journal of biochemistry / FEBS 1993;217(1):45-52.
1993: Proost P; Wuyts A; Conings R; Lenaerts J P; Billiau A; Opdenakker G; Van Damme J
Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines.
Biochemistry 1993;32(38):10170-7.
1993: Proost P; Van Damme J; Opdenakker G
Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein.
Biochemical and biophysical research communications 1993;192(3):1175-81.
1993: Opdenakker G; Froyen G; Fiten P; Proost P; Van Damme J
Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines.
Biochemical and biophysical research communications 1993;191(2):535-42.
1993: Houde M; de Bruyne G; Bracke M; Ingelman-Sundberg M; Skoglund G; Masure S; van Damme J; Opdenakker G
Differential regulation of gelatinase B and tissue-type plasminogen activator expression in human Bowes melanoma cells.
International journal of cancer. Journal international du cancer 1993;53(3):395-400.
1993: Proost P; De Wolf-Peeters C; Conings R; Opdenakker G; Billiau A; Van Damme J
Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):1000-10.
1993: Van Damme J; Proost P; Lenaerts J P; Conings R; Opdenakker G; Billiau A
Monocyte chemotactic proteins related to human MCP-1.
Advances in experimental medicine and biology 1993;351():111-8.
1992: Gijbels K; Masure S; Carton H; Opdenakker G
Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders.
Journal of neuroimmunology 1992;41(1):29-34.
1992: Van Ranst M; Fuse A; Fiten P; Beuken E; Pfister H; Burk R D; Opdenakker G
Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations.
Virology 1992;190(2):587-96.
1992: Fuse A; Simizu B; Van Ranst M; Opdenakker G; Van Damme J
The induction of IL-6 and gelatinase B by IL-1 in mouse cell lines transformed with bovine papillomavirus: decreased production in tumorigenic cells.
Lymphokine and cytokine research 1992;11(4):215-20.
1992: Van Damme J; Proost P; Lenaerts J P; Opdenakker G
Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.
The Journal of experimental medicine 1992;176(1):59-65.
1992: Opdenakker G; Van Damme J
Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.
Cytokine 1992;4(4):251-8.
1991: Opdenakker G; Masure S; Grillet B; Van Damme J
Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.
Lymphokine and cytokine research 1991;10(4):317-24.
1991: Vandekerckhove F; Opdenakker G; Van Ranst M; Lenaerts J P; Put W; Billiau A; Van Damme J
Bradykinin induces interleukin-6 and synergizes with interleukin-1.
Lymphokine and cytokine research 1991;10(4):285-9.
1991: Van Ranst M; Fuse A; Sobis H; De Meurichy W; Syrjänen S M; Billiau A; Opdenakker G
A papillomavirus related to HPV type 13 in oral focal epithelial hyperplasia in the pygmy chimpanzee.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 1991;20(7):325-31.
1991: Van Damme J; Decock B; Bertini R; Conings R; Lenaerts J P; Put W; Opdenakker G; Mantovani A
Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene.
European journal of biochemistry / FEBS 1991;199(1):223-9.
1991: Opdenakker G; Masure S; Proost P; Billiau A; van Damme J
Natural human monocyte gelatinase and its inhibitor.
FEBS letters 1991;284(1):73-8.
1991: Masure S; Proost P; Van Damme J; Opdenakker G
Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8.
European journal of biochemistry / FEBS 1991;198(2):391-8.
1991: Van Ranst M; Norga K; Masure S; Proost P; Vandekerckhove F; Auwerx J; Van Damme J; Opdenakker G
The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.
Cytokine 1991;3(3):231-9.
1990: Masure S; Billiau A; Van Damme J; Opdenakker G
Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate.
Biochimica et biophysica acta 1990;1054(3):317-25.
1990: Van Damme J; Bunning R A; Conings R; Graham R; Russell G; Opdenakker G
Characterization of granulocyte chemotactic activity from human cytokine-stimulated chondrocytes as interleukin 8.
Cytokine 1990;2(2):106-11.
1990: Cabeza-Arvelaiz Y; Dillen C; Heremans H; Van Damme J; Cailleau J; Billiau A; Opdenakker G
Cholera and pertussis exotoxins protect mice against the lethal Schwartzman reaction and antagonize the effects of lipopolysaccharide on second messenger systems.
Lymphokine research 1990;9(2):125-35.
1989: Parekh R B; Dwek R A; Thomas J R; Opdenakker G; Rademacher T W; Wittwer A J; Howard S C; Nelson R; Siegel N R; Jennings M G
Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator.
Biochemistry 1989;28(19):7644-62.
1989: Van Damme J; Decock B; Conings R; Lenaerts J P; Opdenakker G; Billiau A
The chemotactic activity for granulocytes produced by virally infected fibroblasts is identical to monocyte-derived interleukin 8.
European journal of immunology 1989;19(7):1189-94.
1989: Masure S; Opdenakker G
Cytokine-mediated proteolysis in tissue remodelling.
Experientia 1989;45(6):542-9.
1989: Opdenakker G; Cabeza-Arvelaiz Y; Van Damme J
Interaction of interferon with other cytokines.
Experientia 1989;45(6):513-20.
1989: Van Damme J; Schaafsma M R; Fibbe W E; Falkenburg J H; Opdenakker G; Billiau A
Simultaneous production of interleukin 6, interferon-beta and colony-stimulating activity by fibroblasts after viral and bacterial infection.
European journal of immunology 1989;19(1):163-8.
1988: Opdenakker G; Bosman F; Decock B; Cabeza-Arvelaiz Y; Van Damme J; Billiau A
Heterogeneity of human tissue-type plasminogen activator.
FEBS letters 1988;238(1):129-34.
1988: Van Damme J; Van Beeumen J; Opdenakker G; Billiau A
A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity.
The Journal of experimental medicine 1988;167(4):1364-76.

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