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Patricia Opresko

Research Profile

Chemicals & Drugs

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Protein Structure, Tertiary

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Publications

TOP 3
Nancy Adler; Elizabeth Blackburn; Richard M Cawthon; Tamara B Harris; Annemarie Koster; Anne Newman; Aoife O'Donovan; Patricia L Opresko; Matthew S Pantell; Elissa S Epel
Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.
Helen Hwang; Noah Buncher; Patricia L Opresko; Sua Myong
POT1-TPP1 regulates telomeric overhang structural dynamics.
Rama Rao Damerla; Kelly E Knickelbein; Fu-Jun Liu; Steven Strutt; Hong Wang; Patricia L Opresko
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.

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All Publications

2013: Nancy Adler; Elizabeth Blackburn; Richard M Cawthon; Tamara B Harris; Annemarie Koster; Anne Newman; Aoife O'Donovan; Patricia L Opresko; Matthew S Pantell; Elissa S Epel
Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.
Brain, behavior, and immunity 2013;27(1):15-21.
2012: Helen Hwang; Noah Buncher; Patricia L Opresko; Sua Myong
POT1-TPP1 regulates telomeric overhang structural dynamics.
Structure (London, England : 1993) 2012;20(11):1872-80.
2012: Rama Rao Damerla; Kelly E Knickelbein; Fu-Jun Liu; Steven Strutt; Hong Wang; Patricia L Opresko
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
Cell cycle (Georgetown, Tex.) 2012;11(16):3036-44.
2012: Adam S Miller; Patricia L Opresko; Lata Balakrishnan; Noah A Buncher; Robert A Bambara
Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.
Cell cycle (Georgetown, Tex.) 2012;11(5):998-1007.
2011: Jason L Sanders; Robert M Boudreau; Richard M Cawthon; Yvette P Conley; Steven R Cummings; Tamara B Harris; Wen-Chi Hsueh; Alessandro Iannaccone; Steven B Kritchevsky; Michael A Nalls; Anne B Newman; Patricia L Opresko
The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(6):639-45.
2011: Hong Wang; Gerald J Nora; Harshad Ghodke; Patricia L Opresko
Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.
The Journal of biological chemistry 2011;286(9):7479-89.
2011: Aoife O'Donovan; Patricia L Opresko; Matthew S Pantell; Eli Puterman; Susan M Rubin; Suzanne Satterfield; Kristine Yaffe; Hilsa N Ayonayon; Elizabeth H Blackburn; Richard M Cawthon; Firdaus S Dhabhar; Elissa S Epel; Tamara B Harris; Wen-Chi Hsueh; Anne B Newman
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
PloS one 2011;6(5):e19687.
2010: Rama Rao Damerla; Kelly E Knickelbein; Devin Kepchia; Abbe Jackson; Bruce A Armitage; Kristin A Eckert; Patricia L Opresko
Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability.
DNA repair 2010;9(11):1119-29.
2010: Gerald J Nora; Noah A Buncher; Patricia L Opresko
Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.
Nucleic acids research 2010;38(12):3984-98.
2010: Rika Kusumoto-Matsuo; Patricia L Opresko; Dale Ramsden; Hidetoshi Tahara; Vilhelm A Bohr
Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops.
Aging 2010;2(5):274-84.
2010: Fu-Jun Liu; Aaron Barchowsky; Patricia L Opresko
The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.
PloS one 2010;5(6):e11152.
2009: Gregory Sowd; Hong Wang; Dalyir Pretto; Walter J Chazin; Patricia L Opresko
Replication protein A stimulates the Werner syndrome protein branch migration activity.
The Journal of biological chemistry 2009;284(50):34682-91.
2009: Jason L Sanders; Jane A Cauley; Robert M Boudreau; Joseph Zmuda; Elsa S Strotmeyer; Patricia L Opresko; Wen-Chi Hsueh; Richard M Cawthon; Rongling Li; Tamara B Harris; Steven B Kritchevsky; Anne B Newman
Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(9):1531-6.
2009: Fu-Jun Liu; Aaron Barchowsky; Patricia L Opresko
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):307-18.
2009: Patricia L Opresko; Gregory Sowd; Hong Wang
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
PloS one 2009;4(3):e4825.
2008: Gregory Sowd; Ming Lei; Patricia L Opresko
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase.
Nucleic acids research 2008;36(13):4242-56.
2008: Patricia L Opresko
Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
Mechanisms of ageing and development 2008;129(1-2):79-90.
2007: Patricia L Opresko; José Palacios Calvo; Cayetano von Kobbe
Role for the Werner syndrome protein in the promotion of tumor cell growth.
Mechanisms of ageing and development 2007;128(7-8):423-36.
2006: Mark S Eller; Xiaodong Liao; SuiYang Liu; Kendra Hanna; Helena Bäckvall; Patricia L Opresko; Vilhelm A Bohr; Barbara A Gilchrest
A role for WRN in telomere-based DNA damage responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15073-8.
2006: Peisu Zhang; Katsutoshi Furukawa; Patricia L Opresko; Xiangru Xu; Vilhelm A Bohr; Mark P Mattson
TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.
Journal of neurochemistry 2006;97(2):567-81.
2006: Robert M Brosh; Patricia L Opresko; Vilhelm A Bohr
Enzymatic mechanism of the WRN helicase/nuclease.
Methods in enzymology 2006;409():52-85.
2006: Wen-Hsing Cheng; Rika Kusumoto; Patricia L Opresko; XiuFen Sui; Shurong Huang; Matthew L Nicolette; Tanya T Paull; Judith Campisi; Michael M Seidman; Vilhelm A Bohr
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.
Nucleic acids research 2006;34(9):2751-60.
2006: Jeanine A Harrigan; David Michael Wilson; Rajendra Prasad; Patricia L Opresko; Gad Beck; Alfred May; Samuel H Wilson; Vilhelm A Bohr
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.
Nucleic acids research 2006;34(2):745-54.
2006: Meltem Muftuoglu; Heng-Kuan Wong; Syed Z Imam; David Michael Wilson; Vilhelm A Bohr; Patricia L Opresko
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta.
Cancer research 2006;66(1):113-24.
2005: Patricia L Opresko; Penelope A Mason; Elaine R Podell; Ming Lei; Ian D Hickson; Thomas R Cech; Vilhelm A Bohr
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
The Journal of biological chemistry 2005;280(37):32069-80.
2005: Patricia L Opresko; JINSHUI FAN; Shamika Danzy; David Michael Wilson; Vilhelm A Bohr
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2.
Nucleic acids research 2005;33(4):1230-9.
2005: Jae Wan Lee; Jeanine A Harrigan; Patricia L Opresko; Vilhelm A Bohr
Pathways and functions of the Werner syndrome protein.
Mechanisms of ageing and development 2005;126(1):79-86.
2004: Patricia L Opresko; Marit Otterlei; Jesper Graakjaer; Per Bruheim; Lale Dawut; Steen Kølvraa; Alfred May; Michael M Seidman; Vilhem A Bohr
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
Molecular cell 2004;14(6):763-74.
2004: Wen-Hsing Cheng; Cayetano von Kobbe; Patricia L Opresko; L Matthew Arthur; Kenshi Komatsu; Michael M Seidman; James P Carney; Vilhelm A Bohr
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
The Journal of biological chemistry 2004;279(20):21169-76.
2004: Patricia L Opresko; Wen-Hsing Cheng; Vilhelm A Bohr
Junction of RecQ helicase biochemistry and human disease.
The Journal of biological chemistry 2004;279(18):18099-102.
2003: Cayetano von Kobbe; Jeanine A Harrigan; Alfred May; Patricia L Opresko; Lale Dawut; Wen-Hsing Cheng; Vilhelm A Bohr
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.
Molecular and cellular biology 2003;23(23):8601-13.
2003: Jean-Philippe Laine; Patricia L Opresko; Fred E Indig; Jeanine A Harrigan; Cayetano von Kobbe; Vilhelm A Bohr
Werner protein stimulates topoisomerase I DNA relaxation activity.
Cancer research 2003;63(21):7136-46.
2003: Wen-Hsing Cheng; Cayetano von Kobbe; Patricia L Opresko; Kesha M Fields; Jian Ren; Donald Kufe; Vilhelm A Bohr
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.
Molecular and cellular biology 2003;23(18):6385-95.
2003: Jeanine A Harrigan; Patricia L Opresko; Cayetano von Kobbe; Padmini S Kedar; Rajendra Prasad; Samuel H Wilson; Vilhelm A Bohr
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.
The Journal of biological chemistry 2003;278(25):22686-95.
2003: Patricia L Opresko; Wen-Hsing Cheng; Cayetano von Kobbe; Jeanine A Harrigan; Vilhelm A Bohr
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.
Carcinogenesis 2003;24(5):791-802.
2002: Patricia L Opresko; Cayetano von Kobbe; Jean-Philippe Laine; Jeanine A Harrigan; Ian D Hickson; Vilhelm A Bohr
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
The Journal of biological chemistry 2002;277(43):41110-9.
2002: Cayetano von Kobbe; parimal karmakar; Lale Dawut; Patricia L Opresko; Xianmin Zeng; Robert M Brosh; Ian D Hickson; Vilhelm A Bohr
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
The Journal of biological chemistry 2002;277(24):22035-44.
2002: Vilhelm A Bohr; Robert M Brosh; Cayetano von Kobbe; Patricia L Opresko; parimal karmakar
Pathways defective in the human premature aging disease Werner syndrome.
Biogerontology 2002;3(1-2):89-94.
2001: Patricia L Opresko; Jean-Philippe Laine; Robert M Brosh; Michael M Seidman; Vilhelm A Bohr
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
The Journal of biological chemistry 2001;276(48):44677-87.
2001: Robert M Brosh; Cayetano von Kobbe; Joshua Sommers; parimal karmakar; Patricia L Opresko; Jason Piotrowski; Irina I Dianova; Grigory L Dianov; Vilhelm A Bohr
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
The EMBO journal 2001;20(20):5791-801.