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Arie Ordentlich

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Physiology

Anatomy

Cell Line

Phenomena

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Amino Acid Sequence

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Insertional Mutagenesis

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Co-Publications
Name
40
Shafferman, Avigdor
32
Velan, Baruch
29
Barak, Dov
27
Kronman, Chanoch
17
Ariel, Naomi
11
Segall, Yoffi
9
Kaplan, Dana
4
Barak, R
3
Cohen, Ofer
3
Mizrahi, Dana
2
Lazar, Arie
2
Millard, Charles
2
Silman, Israel
2
Sussman, Joel
2
de Jong, L P A

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Publications

TOP 3
Lustig Shlomo; Maik-Rachline Galia; Paran Nir; Melamed Sharon; Israely Tomer; Erez Noam; Orr Nadav; Reuveny Shaul; Ordentlich Arie; Laub Orgad; Shafferman Avigdor; Velan Baruch
Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.
Barak Dov; Ordentlich Arie; Stein Dana; Yu Qian-Sheng; Greig Nigel H; Shafferman Avigdor
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.
Rosenfeld Ronit; Marcus Hadar; Ben-Arie Einat; Lachmi Bat-El; Mechaly Adva; Reuveny Shaul; Gat Orit; Mazor Ohad; Ordentlich Arie
Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infection.

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All Publications

2009: Lustig Shlomo; Maik-Rachline Galia; Paran Nir; Melamed Sharon; Israely Tomer; Erez Noam; Orr Nadav; Reuveny Shaul; Ordentlich Arie; Laub Orgad; Shafferman Avigdor; Velan Baruch
Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response.
Vaccine 2009;27(11):1691-9.
2009: Barak Dov; Ordentlich Arie; Stein Dana; Yu Qian-Sheng; Greig Nigel H; Shafferman Avigdor
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.
The Biochemical journal 2009;417(1):213-22.
2009: Rosenfeld Ronit; Marcus Hadar; Ben-Arie Einat; Lachmi Bat-El; Mechaly Adva; Reuveny Shaul; Gat Orit; Mazor Ohad; Ordentlich Arie
Isolation and chimerization of a highly neutralizing antibody conferring passive protection against lethal Bacillus anthracis infection.
PloS one 2009;4(7):e6351.
2008: Mazor Ohad; Cohen Ofer; Kronman Chanoch; Raveh Lily; Stein Dana; Ordentlich Arie; Shafferman Avigdor
Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Molecular pharmacology 2008;74(3):755-63.
2008: Shafferman Avigdor; Barak Dov; Stein Dana; Kronman Chanoch; Velan Baruch; Greig Nigel H; Ordentlich Arie
Flexibility versus "rigidity" of the functional architecture of AChE active center.
Chemico-biological interactions 2008;175(1-3):166-72.
2007: Kronman Chanoch; Cohen Ofer; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication.
Toxicology 2007;233(1-3):40-6.
2006: Cohen Ofer; Kronman Chanoch; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Molecular pharmacology 2006;70(3):1121-31.
2005: Barak Dov; Ordentlich Arie; Kaplan Dana; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.
Chemico-biological interactions 2005;157-158():219-26.
2005: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.
Chemico-biological interactions 2005;157-158():191-8.
2005: Shafferman Avigdor; Barak Dov; Kaplan Dana; Ordentlich Arie; Kronman Chanoch; Velan Baruch
Functional requirements for the optimal catalytic configuration of the AChE active center.
Chemico-biological interactions 2005;157-158():123-31.
2004: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.
Biochemistry 2004;43(35):11255-65.
2004: Kaplan Dana; Barak Dov; Ordentlich Arie; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?
Biochemistry 2004;43(11):3129-36.
2002: Cléry-Barraud Cécile; Ordentlich Arie; Grosfeld Haim; Shafferman Avigdor; Masson Patrick
Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability.
European journal of biochemistry / FEBS 2002;269(17):4297-307.
2002: Barak Dov; Kaplan Dana; Ordentlich Arie; Ariel Naomi; Velan Baruch; Shafferman Avigdor
The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.
Biochemistry 2002;41(26):8245-52.
2001: Cohen O; Kronman C; Chitlaru T; Ordentlich A; Velan B; Shafferman A
Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.
The Biochemical journal 2001;357(Pt 3):795-802.
2001: Elhanany E; Ordentlich A; Dgany O; Kaplan D; Segall Y; Barak R; Velan B; Shafferman A
Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts.
Chemical research in toxicology 2001;14(7):912-8.
2001: Kaplan D; Ordentlich A; Barak D; Ariel N; Kronman C; Velan B; Shafferman A
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Biochemistry 2001;40(25):7433-45.
2000: Barak D; Ordentlich A; Kaplan D; Barak R; Mizrahi D; Kronman C; Segall Y; Velan B; Shafferman A
Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.
Biochemistry 2000;39(5):1156-61.
1999: Millard C B; Kryger G; Ordentlich A; Greenblatt H M; Harel M; Raves M L; Segall Y; Barak D; Shafferman A; Silman I; Sussman J L
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
1999: Silman I; Millard C B; Ordentlich A; Greenblatt H M; Harel M; Barak D; Shafferman A; Sussman J L
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
1999: Ordentlich A; Barak D; Kronman C; Benschop H P; De Jong L P; Ariel N; Barak R; Segall Y; Velan B; Shafferman A
Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Biochemistry 1999;38(10):3055-66.
1998: Chitlaru T; Kronman C; Zeevi M; Kam M; Harel A; Ordentlich A; Velan B; Shafferman A
Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.
The Biochemical journal 1998;336 ( Pt 3)():647-58.
1998: Ariel N; Ordentlich A; Barak D; Bino T; Velan B; Shafferman A
The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
The Biochemical journal 1998;335 ( Pt 1)():95-102.
1998: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Functional characteristics of the oxyanion hole in human acetylcholinesterase.
The Journal of biological chemistry 1998;273(31):19509-17.
1997: Shafferman A; Ordentlich A; Barak D; Stein D; Ariel N; Velan B
Aging of somanyl-acetylcholinesterase adducts: facts and models.
The Biochemical journal 1997;324 ( Pt 3)():996-8.
1997: Barak R; Ordentlich A; Barak D; Fischer M; Benschop H P; De Jong L P; Segall Y; Velan B; Shafferman A
Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry.
FEBS letters 1997;407(3):347-52.
1996: Velan B; Barak D; Ariel N; Leitner M; Bino T; Ordentlich A; Shafferman A
Structural modifications of the omega loop in human acetylcholinesterase.
FEBS letters 1996;395(1):22-8.
1996: Shafferman A; Ordentlich A; Barak D; Stein D; Ariel N; Velan B
Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.
The Biochemical journal 1996;318 ( Pt 3)():833-40.
1996: Grosfeld H; Barak D; Ordentlich A; Velan B; Shafferman A
Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.
Molecular pharmacology 1996;50(3):639-49.
1996: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
The Journal of biological chemistry 1996;271(20):11953-62.
1995: Barak D; Ordentlich A; Bromberg A; Kronman C; Marcus D; Lazar A; Ariel N; Velan B; Shafferman A
Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.
Biochemistry 1995;34(47):15444-52.
1995: Kronman C; Velan B; Marcus D; Ordentlich A; Reuveny S; Shafferman A
Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.
The Biochemical journal 1995;311 ( Pt 3)():959-67.
1995: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
The Journal of biological chemistry 1995;270(5):2082-91.
1994: Kronman C; Ordentlich A; Barak D; Velan B; Shafferman A
The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.
The Journal of biological chemistry 1994;269(45):27819-22.
1994: Shafferman A; Ordentlich A; Barak D; Kronman C; Ber R; Bino T; Ariel N; Osman R; Velan B
Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.
The EMBO journal 1994;13(15):3448-55.
1994: Barak D; Kronman C; Ordentlich A; Ariel N; Bromberg A; Marcus D; Lazar A; Velan B; Shafferman A
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
The Journal of biological chemistry 1994;269(9):6296-305.
1993: Velan B; Kronman C; Ordentlich A; Flashner Y; Leitner M; Cohen S; Shafferman A
N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
The Biochemical journal 1993;296 ( Pt 3)():649-56.
1993: Ordentlich A; Kronman C; Barak D; Stein D; Ariel N; Marcus D; Velan B; Shafferman A
Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
FEBS letters 1993;334(2):215-20.
1993: Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
The Journal of biological chemistry 1993;268(23):17083-95.
1992: Shafferman A; Velan B; Ordentlich A; Kronman C; Grosfeld H; Leitner M; Flashner Y; Cohen S; Barak D; Ariel N
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
The EMBO journal 1992;11(10):3561-8.
1992: Shafferman A; Kronman C; Flashner Y; Leitner M; Grosfeld H; Ordentlich A; Gozes Y; Cohen S; Ariel N; Barak D
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
The Journal of biological chemistry 1992;267(25):17640-8.

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