FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Christine Orengo

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Protein Folding

Phenomena

Evolution, Molecular

Genes & Molecular Sequences

Occupations

Procedures

Co-author Network

Publications

TOP 3
Romain A Studer; Benoit H Dessailly; Christine A Orengo
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.
Robert Rentzsch; Christine A Orengo
Protein function prediction using domain families.
Ian Sillitoe; Romain A Studer; Janet M Thornton; Corin Yeats; Robert Rentzsch; Alison L Cuff; Natalie L Dawson; Benoit H Dessailly; Nicholas Furnham; David Lee; Jonathan G Lees; Tony E Lewis; Christine A Orengo
New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Christine Orengo (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Romain A Studer; Benoit H Dessailly; Christine A Orengo
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.
The Biochemical journal 2013;449(3):581-94.
2013: Robert Rentzsch; Christine A Orengo
Protein function prediction using domain families.
BMC bioinformatics 2013;14 Suppl 3():S5.
2013: Ian Sillitoe; Romain A Studer; Janet M Thornton; Corin Yeats; Robert Rentzsch; Alison L Cuff; Natalie L Dawson; Benoit H Dessailly; Nicholas Furnham; David Lee; Jonathan G Lees; Tony E Lewis; Christine A Orengo
New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.
Nucleic acids research 2013;41(Database issue):D490-8.
2012: Ebele Usifo; Ros A Whittall; Corin Yeats; Jacopo Celli; Sarah E A Leigh; Nicholas Lench; Andrew C R Martin; Christine A Orengo; Alison Taylor; Steve E Humphries
Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment.
Annals of human genetics 2012;76(5):387-401.
2012: Nicholas Furnham; Gemma L Holliday; Roman A Laskowski; Christine A Orengo; Ian Sillitoe; Alison L Cuff; Janet M Thornton
Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.
PLoS computational biology 2012;8(3):e1002403.
2011: J G Lees; J K Heriche; I Morilla; Juan A G Ranea; Christine A Orengo
Systematic computational prediction of protein interaction networks.
Physical biology 2011;8(3):035008.
2011: David Lee; Tjaart de Beer; Roman A Laskowski; Janet M Thornton; Christine A Orengo
1,000 structures and more from the MCSG.
BMC structural biology 2011;11():2.
2011: Alison L Cuff; Ian Sillitoe; Tony Lewis; Andrew B Clegg; Robert Rentzsch; Nicholas Furnham; Marialuisa Pellegrini-Calace; David Jones; Janet Thornton; Christine A Orengo
Extending CATH: increasing coverage of the protein structure universe and linking structure with function.
Nucleic acids research 2011;39(Database issue):D420-6.
2010: Benoit H Dessailly; Oliver C Redfern; Alison L Cuff; Christine A Orengo
Detailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classification.
Structure (London, England : 1993) 2010;18(11):1522-35.
2010: Adam J Reid; Juan A G Ranea; Andrew B Clegg; Christine A Orengo
CODA: accurate detection of functional associations between proteins in eukaryotic genomes using domain fusion.
PloS one 2010;5(6):e10908.
2010: Adam J Reid; Juan Ag Ranea; Christine A Orengo
Comparative evolutionary analysis of protein complexes in E. coli and yeast.
BMC genomics 2010;11():79.
2009: Oliver Redfern; Benoît H Dessailly; Timothy J Dallman; Ian Sillitoe; Christine A Orengo
FLORA: a novel method to predict protein function from structure in diverse superfamilies.
PLoS computational biology 2009;5(8):e1000485.
2009: Benoît H Dessailly; Adam J Reid; Corin Yeats; Jonathan G Lees; Alison Cuff; Christine A Orengo
The evolution of protein functions and networks: a family-centric approach.
Biochemical Society transactions 2009;37(Pt 4):745-50.
2009: Benoît H Dessailly; Oliver C Redfern; Alison Cuff; Christine A Orengo
Exploiting structural classifications for function prediction: towards a domain grammar for protein function.
Current opinion in structural biology 2009;19(3):349-56.
2009: Robert Rentzsch; Christine A Orengo
Protein function prediction--the power of multiplicity.
Trends in biotechnology 2009;27(4):210-9.
2009: Sarah Addou; Robert Rentzsch; David Lee; Christine A Orengo
Domain-based and family-specific sequence identity thresholds increase the levels of reliable protein function transfer.
Journal of molecular biology 2009;387(2):416-30.
2009: Jose M G Izarzugaza; Anja Baresic; Lisa E M McMillan; Corin Yeats; Andrew B Clegg; Christine A Orengo; Andrew C R Martin; Alfonso Valencia
An integrated approach to the interpretation of single amino acid polymorphisms within the framework of CATH and Gene3D.
BMC bioinformatics 2009;10 Suppl 8():S5.
2008: A E Lobley; T Nugent; Christine A Orengo; David T Jones
FFPred: an integrated feature-based function prediction server for vertebrate proteomes.
Nucleic acids research 2008;36(Web Server issue):W297-302.
2008: Oliver C Redfern; Benoit Dessailly; Christine A Orengo
Exploring the structure and function paradigm.
Current opinion in structural biology 2008;18(3):394-402.
2008: Russell L Marsden; Christine A Orengo
The classification of protein domains.
Methods in molecular biology (Clifton, N.J.) 2008;453():123-46.
2008: Russell L Marsden; Christine A Orengo
Target selection for structural genomics: an overview.
Methods in molecular biology (Clifton, N.J.) 2008;426():3-25.
2007: Juan A G Ranea; Corin Yeats; Alastair Grant; Christine A Orengo
Predicting protein function with hierarchical phylogenetic profiles: the Gene3D Phylo-Tuner method applied to eukaryotic genomes.
PLoS computational biology 2007;3(11):e237.
2007: Oliver Redfern; Andrew Harrison; Timothy J Dallman; Frances Pearl; Christine A Orengo
CATHEDRAL: a fast and effective algorithm to predict folds and domain boundaries from multidomain protein structures.
PLoS computational biology 2007;3(11):e232.
2007: Adam James Reid; Corin Yeats; Christine A Orengo
Methods of remote homology detection can be combined to increase coverage by 10% in the midnight zone.
Bioinformatics (Oxford, England) 2007;23(18):2353-60.
2007: Anna Lobley; Mark B Swindells; Christine A Orengo; David T Jones
Inferring function using patterns of native disorder in proteins.
PLoS computational biology 2007;3(8):e162.
2007: Andrew P Harrison; Caroline E Johnston; Christine A Orengo
Establishing a major cause of discrepancy in the calibration of Affymetrix GeneChips.
BMC bioinformatics 2007;8():195.
2007: Russell L Marsden; Tony A Lewis; Christine A Orengo
Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint.
BMC bioinformatics 2007;8():86.
2007: Lesley H Greene; Tony E Lewis; Sarah Addou; Alison Cuff; Timothy J Dallman; Mark Dibley; Oliver Redfern; Frances Pearl; Rekha Nambudiry; Adam Reid; Ian Sillitoe; Corin Yeats; Janet M Thornton; Christine A Orengo
The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution.
Nucleic acids research 2007;35(Database issue):D291-7.
2006: Juan A G Ranea; Antonio Sillero; Janet M Thornton; Christine A Orengo
Protein superfamily evolution and the last universal common ancestor (LUCA).
Journal of molecular evolution 2006;63(4):513-25.
2006: Gabrielle A Reeves; Timothy J Dallman; Oliver Redfern; Adrian Akpor; Christine A Orengo
Structural diversity of domain superfamilies in the CATH database.
Journal of molecular biology 2006;360(3):725-41.
2006: Russell L Marsden; Juan A G Ranea; Antonio Sillero; Oliver Redfern; Corin Yeats; Michael Maibaum; David Lee; Sarah Addou; Gabrielle A Reeves; Timothy J Dallman; Christine A Orengo
Exploiting protein structure data to explore the evolution of protein function and biological complexity.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1467):425-40.
2006: Ilhem Diboun; Lorenz Wernisch; Christine A Orengo; Martin Koltzenburg
Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma.
BMC genomics 2006;7():252.
2006: Russell L Marsden; David Lee; Michael Maibaum; Corin Yeats; Christine A Orengo
Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space.
Nucleic acids research 2006;34(3):1066-80.
2006: Corin Yeats; Michael Maibaum; Russell L Marsden; Mark Dibley; David Lee; Sarah Addou; Christine A Orengo
Gene3D: modelling protein structure, function and evolution.
Nucleic acids research 2006;34(Database issue):D281-4.
2005: Annabel E Todd; Russell L Marsden; Janet M Thornton; Christine A Orengo
Progress of structural genomics initiatives: an analysis of solved target structures.
Journal of molecular biology 2005;348(5):1235-60.
2005: Christine A Orengo; Janet M Thornton
Protein families and their evolution-a structural perspective.
Annual review of biochemistry 2005;74():867-900.
2005: Juan A G Ranea; Alastair Grant; Janet M Thornton; Christine A Orengo
Microeconomic principles explain an optimal genome size in bacteria.
Trends in genetics : TIG 2005;21(1):21-5.
2004: James E Bray; Russell L Marsden; Stuart C G Rison; Alexei Savchenko; Aled M Edwards; Janet M Thornton; Christine A Orengo
A practical and robust sequence search strategy for structural genomics target selection.
Bioinformatics (Oxford, England) 2004;20(14):2288-95.
2004: Juan A G Ranea; Daniel W A Buchan; Janet M Thornton; Christine A Orengo
Evolution of protein superfamilies and bacterial genome size.
Journal of molecular biology 2004;336(4):871-87.
2003: James D Watson; Annabel E Todd; James Bray; Roman A Laskowski; Aled Edwards; Andrzej Joachimiak; Christine A Orengo; Janet M Thornton
Target selection and determination of function in structural genomics.
IUBMB life 2003;55(4-5):249-55.
2003: Christine A Orengo; Frances Pearl; Janet M Thornton
The CATH domain structure database.
Methods of biochemical analysis 2003;44():249-71.
2003: Daniel W A Buchan; Stuart C G Rison; James E Bray; David Lee; Frances Pearl; Janet M Thornton; Christine A Orengo
Gene3D: structural assignments for the biologist and bioinformaticist alike.
Nucleic acids research 2003;31(1):469-73.
2003: Frances Pearl; C F Bennett; James E Bray; Andrew P Harrison; N Martin; A Shepherd; Ian Sillitoe; Janet Thornton; Christine A Orengo
The CATH database: an extended protein family resource for structural and functional genomics.
Nucleic acids research 2003;31(1):452-5.
2002: Adrian J Shepherd; Nigel J Martin; Roger G Johnson; Kellam Paul; Christine A Orengo
PFDB: a generic protein family database integrating the CATH domain structure database with sequence based protein family resources.
Bioinformatics (Oxford, England) 2002;18(12):1666-72.
2002: Annabel E Todd; Christine A Orengo; Janet M Thornton
Sequence and structural differences between enzyme and nonenzyme homologs.
Structure (London, England : 1993) 2002;10(10):1435-51.
2002: Nozomi Nagano; Christine A Orengo; Janet M Thornton
One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions.
Journal of molecular biology 2002;321(5):741-65.
2002: Annabel E Todd; Christine A Orengo; Janet M Thornton
Plasticity of enzyme active sites.
Trends in biochemical sciences 2002;27(8):419-26.
2002: Daniel W A Buchan; Adrian J Shepherd; David Lee; Frances Pearl; Stuart C G Rison; Janet M Thornton; Christine A Orengo
Gene3D: structural assignment for whole genes and genomes using the CATH domain structure database.
Genome research 2002;12(3):503-14.
2002: Frances Pearl; David Lee; James E Bray; Daniel W A Buchan; Adrian J Shepherd; Christine A Orengo
The CATH extended protein-family database: providing structural annotations for genome sequences.
Protein science : a publication of the Protein Society 2002;11(2):233-44.
2002: Christine A Orengo; James E Bray; Daniel W A Buchan; Andrew Harrison; David Lee; Frances Pearl; Ian Sillitoe; Annabel E Todd; Janet M Thornton
The CATH protein family database: a resource for structural and functional annotation of genomes.
Proteomics 2002;2(1):11-21.
2001: Christine A Orengo; Ian Sillitoe; G Reeves; Frances Pearl
Review: what can structural classifications reveal about protein evolution?
Journal of structural biology 2001;134(2-3):145-65.
2001: Annabel E Todd; Christine A Orengo; Janet M Thornton
Evolution of function in protein superfamilies, from a structural perspective.
Journal of molecular biology 2001;307(4):1113-43.
2001: M Mar Albà; R Das; Christine A Orengo; Kellam Paul
Genomewide function conservation and phylogeny in the Herpesviridae.
Genome research 2001;11(1):43-54.
2001: Frances Pearl; N Martin; James E Bray; Daniel W A Buchan; Andrew P Harrison; David Lee; Gabrielle A Reeves; Adrian J Shepherd; Ian Sillitoe; Annabel E Todd; Janet M Thornton; Christine A Orengo
A rapid classification protocol for the CATH Domain Database to support structural genomics.
Nucleic acids research 2001;29(1):223-7.
2001: M Mar Albà; David Lee; Frances Pearl; Adrian J Shepherd; N Martin; Christine A Orengo; Kellam Paul
VIDA: a virus database system for the organization of animal virus genome open reading frames.
Nucleic acids research 2001;29(1):133-6.
2000: Janet M Thornton; Annabel E Todd; D Milburn; Neera Borkakoti; Christine A Orengo
From structure to function: approaches and limitations.
Nature structural biology 2000;7 Suppl():991-4.
2000: James E Bray; Annabel E Todd; Frances Pearl; Janet M Thornton; Christine A Orengo
The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues.
Protein engineering 2000;13(3):153-65.
2000: Frances Pearl; Annabel E Todd; James E Bray; A C Martin; AA Salamov; M Suwa; Mark B Swindells; Janet M Thornton; Christine A Orengo
Using the CATH domain database to assign structures and functions to the genome sequences.
Biochemical Society transactions 2000;28(2):269-75.
2000: Frances Pearl; David Lee; James E Bray; Ian Sillitoe; Annabel E Todd; Andrew P Harrison; Janet M Thornton; Christine A Orengo
Assigning genomic sequences to CATH.
Nucleic acids research 2000;28(1):277-82.
1999: Janet M Thornton; Christine A Orengo; Annabel E Todd; Frances Pearl
Protein folds, functions and evolution.
Journal of molecular biology 1999;293(2):333-42.
1999: Annabel E Todd; Christine A Orengo; Janet M Thornton
Evolution of protein function, from a structural perspective.
Current opinion in chemical biology 1999;3(5):548-56.
1999: Christine A Orengo; Annabel E Todd; Janet M Thornton
From protein structure to function.
Current opinion in structural biology 1999;9(3):374-82.
1999: Annabel E Todd; Christine A Orengo; Janet M Thornton
DOMPLOT: a program to generate schematic diagrams of the structural domain organization within proteins, annotated by ligand contacts.
Protein engineering 1999;12(5):375-9.
1999: G M Salem; E Gail Hutchinson; Christine A Orengo; Janet M Thornton
Correlation of observed fold frequency with the occurrence of local structural motifs.
Journal of molecular biology 1999;287(5):969-81.
1999: AA Salamov; M Suwa; Christine A Orengo; Mark B Swindells
Genome analysis: Assigning protein coding regions to three-dimensional structures.
Protein science : a publication of the Protein Society 1999;8(4):771-7.
1999: Christine A Orengo
CORA--topological fingerprints for protein structural families.
Protein science : a publication of the Protein Society 1999;8(4):699-715.
1999: AA Salamov; M Suwa; Christine A Orengo; Mark B Swindells
Combining sensitive database searches with multiple intermediates to detect distant homologues.
Protein engineering 1999;12(2):95-100.
1999: Christine A Orengo; James E Bray; Tim Hubbard; L LoConte; Ian Sillitoe
Analysis and assessment of ab initio three-dimensional prediction, secondary structure, and contacts prediction.
Proteins 1999;Suppl 3():149-70.
1999: Christine A Orengo; Frances Pearl; James E Bray; Annabel E Todd; A C Martin; L Lo Conte; Janet M Thornton
The CATH Database provides insights into protein structure/function relationships.
Nucleic acids research 1999;27(1):275-9.
1998: Christine A Orengo; A M Martin; G Hutchinson; Siân Jones; David T Jones; AD Michie; Mark B Swindells; Janet M Thornton
Classifying a protein in the CATH database of domain structures.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 1):1155-67.
1998: A C Martin; Christine A Orengo; E Gail Hutchinson; Siân Jones; M Karmirantzou; Roman A Laskowski; John Mitchell; C Taroni; Janet M Thornton
Protein folds and functions.
Structure (London, England : 1993) 1998;6(7):875-84.
1997: Christine A Orengo; AD Michie; Siân Jones; David T Jones; Mark B Swindells; Janet M Thornton
CATH--a hierarchic classification of protein domain structures.
Structure (London, England : 1993) 1997;5(8):1093-108.
1996: AD Michie; Christine A Orengo; Janet M Thornton
Analysis of domain structural class using an automated class assignment protocol.
Journal of molecular biology 1996;262(2):168-85.
1996: Christine A Orengo; William R Taylor
SSAP: sequential structure alignment program for protein structure comparison.
Methods in enzymology 1996;266():617-35.
1995: Christine A Orengo; Mark B Swindells; AD Michie; Marketa Zvelebil; Paul C Driscoll; Michael D Waterfield; Janet M Thornton
Structural similarity between the pleckstrin homology domain and verotoxin: the problem of measuring and evaluating structural similarity.
Protein science : a publication of the Protein Society 1995;4(10):1977-83.
1994: William R Taylor; T P Flores; Christine A Orengo
Multiple protein structure alignment.
Protein science : a publication of the Protein Society 1994;3(10):1858-70.
1993: T P Flores; Christine A Orengo; D S Moss; Janet M Thornton
Comparison of conformational characteristics in structurally similar protein pairs.
Protein science : a publication of the Protein Society 1993;2(11):1811-26.
1993: Christine A Orengo; Janet M Thornton
Alpha plus beta folds revisited: some favoured motifs.
Structure (London, England : 1993) 1993;1(2):105-20.
1993: Christine A Orengo; William R Taylor
A local alignment method for protein structure motifs.
Journal of molecular biology 1993;233(3):488-97.
1993: Christine A Orengo; T P Flores; William R Taylor; Janet M Thornton
Identification and classification of protein fold families.
Protein engineering 1993;6(5):485-500.
1993: Christine A Orengo; T P Flores; David T Jones; William R Taylor; Janet M Thornton
Recurring structural motifs in proteins with different functions.
Current biology : CB 1993;3(3):131-9.
1992: Christine A Orengo; N P Brown; William R Taylor
Fast structure alignment for protein databank searching.
Proteins 1992;14(2):139-67.
1989: William R Taylor; Christine A Orengo
Protein structure alignment.
Journal of molecular biology 1989;208(1):1-22.
1989: William R Taylor; Christine A Orengo
A holistic approach to protein structure alignment.
Protein engineering 1989;2(7):505-19.