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Marju Orho-Melander

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Physiology

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Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Carlo Pirazzi; Arturo Pujia; Johanna Andersson Assarsson; Marco Giorgio Baroni; Jan Borén; Maria Antonella Burza; Lena M S Carlsson; Ulrika Ericson; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Olov Wiklund; Stefano Romeo
The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.
S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Ulrika Ericson; Bo Gullberg; Sophie Hellstrand; George Hindy; Emily Sonestedt; Elisabet Wirfält; Marju Orho-Melander
High intakes of protein and processed meat associate with increased incidence of type 2 diabetes.

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All Publications

2013: Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Carlo Pirazzi; Arturo Pujia; Johanna Andersson Assarsson; Marco Giorgio Baroni; Jan Borén; Maria Antonella Burza; Lena M S Carlsson; Ulrika Ericson; Kajsa Sjöholm; Lars Sjöström; Per-Arne Svensson; Olov Wiklund; Stefano Romeo
The IRS1 rs2943641 variant and risk of future cancer among morbidly obese individuals.
The Journal of clinical endocrinology and metabolism 2013;98(4):E785-9.
2013: S Lallukka; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; J Perttilä; Ksenia Sevastianova; Antti Hakkarainen; Hannele Yki-Järvinen
Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.
Diabetologia 2013;56(4):886-92.
2013: Ulrika Ericson; Bo Gullberg; Sophie Hellstrand; George Hindy; Emily Sonestedt; Elisabet Wirfält; Marju Orho-Melander
High intakes of protein and processed meat associate with increased incidence of type 2 diabetes.
The British journal of nutrition 2013;109(6):1143-53.
2013: Louise Brunkwall; Ulrika Ericson; Bo Gullberg; Sophie Hellstrand; Marju Orho-Melander; Emily Sonestedt
Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults.
Food & nutrition research 2013;57():.
2013: Ulrika Ericson; Bo Gullberg; Gull Rukh; Emily Sonestedt; Ivana Stojkovic; Peter Wallström; Elisabet Wirfält; Marju Orho-Melander
Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.
The American journal of clinical nutrition 2013;97(1):208-16.
2012: Carlo Pirazzi; Arturo Pujia; Marcus Ståhlman; Marja-Riitta Taskinen; Olov Wiklund; Martin Adiels; Linda Andersson; Jan Borén; Maria Antonella Burza; Malin Levin; Cristina Maglio; Rosellina Margherita Mancina; Tiziana Montalcini; Marju Orho-Melander; Jeanna Perman; Stefano Romeo
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.
Journal of hepatology 2012;57(6):1276-82.
2012: Olle Melander; Peter Nilsson; Peter Almgren; Mattias Belting; Andreas Bergmann; Gunnar Engström; Bo Hedblad; Ute Kilger; Alan S Maisel; Jonas Manjer; Marju Orho-Melander
Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality.
JAMA : the journal of the American Medical Association 2012;308(14):1469-75.
2012: G Hindy; Xing-Jun Jing; U Ericson; Ola Hansson; Erik Renström; Emily Sonestedt; Elisabet Wirfält; Y Zhou; Marju Orho-Melander
Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
Diabetologia 2012;55(10):2646-54.
2012: S Hellstrand; U Ericson; Bo Gullberg; Bo Hedblad; Emily Sonestedt; Elisabet Wirfält; Marju Orho-Melander
Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.
Journal of lipid research 2012;53(6):1183-9.
2012: Emily Sonestedt; Elisabet Wirfält; Ulrika Ericson; Leif Groop; Bo Gullberg; Valeriya Lyssenko; Marju Orho-Melander
Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.
The Journal of clinical endocrinology and metabolism 2012;97(5):E810-8.
2012: Jenni Hyysalo; Anna Kotronen; Ronald M Krauss; Nina Lundbom; Janne Makkonen; Olle Melander; Marju Orho-Melander; Aila Rissanen; Ksenia Sevastianova; Ivana Stojkovic; Antti Hakkarainen; Hannele Yki-Järvinen
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.
Journal of gastroenterology and hepatology 2012;27(5):951-6.
2012: Emily Sonestedt; Peter Wallström; Elisabet Wirfält; Isabel Drake; Bo Gullberg; Bo Hedblad; Joanna Hlebowicz; Ronald M Krauss; Jan Nilsson; Gunilla Nordin Fredrikson; Marju Orho-Melander
High disaccharide intake associates with atherogenic lipoprotein profile.
The British journal of nutrition 2012;107(7):1062-9.
2012: Koert N J Burger; Francesca Crowe; Claus Dethlefsen; José María Huerta; Rudolf Kaaks; Vittorio Krogh; Cecilie Kyrø; Amalia Mattiello; Peter M Nilsson; Marju Orho-Melander; Kim Overvad; Olov Rolandsson; Carlotta Sacerdote; Ivonne Sluijs; Diewertje Sluik; Annemieke M W Spijkerman; Birgit Teucher; Anne Tjønneland; Rosario Tumino; Yvonne T van der Schouw; Naomi Allen; Aurelio Barricarte; Benedetta Bendinelli; Joline W J Beulens; Heiner Boeing; Ute Nöthlings
Dietary fiber, carbohydrate quality and quantity, and mortality risk of individuals with diabetes mellitus.
PloS one 2012;7(8):e43127.
2011: Marja-Riitta Taskinen; Jukka Westerbacka; Martin Adiels; Antti Hakkarainen; Juhani Kahri; Jesper Lundbom; Nina Lundbom; Sven-Olof Olofsson; Marju Orho-Melander; Sanni Söderlund; Jan Borén
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(9):2144-50.
2011: Emily Sonestedt; Peter Wallström; Elisabet Wirfält; Bo Gullberg; Marju Orho-Melander; Bo Hedblad
Dairy products and its association with incidence of cardiovascular disease: the Malmö diet and cancer cohort.
European journal of epidemiology 2011;26(8):609-18.
2011: Emily Sonestedt; Elisabet Wirfält; U Ericson; Bo Gullberg; Bo Hedblad; Marju Orho-Melander
Association between fat intake, physical activity and mortality depending on genetic variation in FTO.
International journal of obesity (2005) 2011;35(8):1041-9.
2011: Ksenia Sevastianova; Laura Suojanen; Eleuterio Ferrannini; Amalia Gastaldelli; Antti Hakkarainen; Anna Kotronen; Jesper Lundbom; Nina Lundbom; Vesa M Olkkonen; Marju Orho-Melander; Julia Perttilä; Aila Rissanen; Hannele Yki-Järvinen
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
The American journal of clinical nutrition 2011;94(1):104-11.
2011: Jens K Hertel; Stefan Johansson; Emily Sonestedt; Anna Jonsson; Rolv T Lie; Carl G P Platou; Peter M Nilsson; Gull Rukh; Kristian Midthjell; Kristian Hveem; Olle Melander; Leif Groop; Valeriya Lyssenko; Anders Molven; Marju Orho-Melander; Pål R Njølstad
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies.
Diabetes 2011;60(5):1637-44.
2011: Peter M Nilsson; Marju Orho-Melander; Olle Melander
[News in cardiovascular genetics open for new therapeutic possibilities].
Läkartidningen 2011;108(10):540-3.
2011: Benjamin M Neale; Manuel A Rivas; Benjamin F Voight; David Altshuler; Bernie Devlin; Marju Orho-Melander; Sekar Kathiresan; Shaun M Purcell; Kathryn Roeder; Mark J Daly
Testing for an unusual distribution of rare variants.
PLoS genetics 2011;7(3):e1001322.
2010: Samuli Ripatti; Emmi Tikkanen; Marju Orho-Melander; Aki S Havulinna; Kaisa Silander; Amitabh Sharma; Candace Guiducci; Markus Perola; Antti Jula; Juha Sinisalo; Marja-Liisa Lokki; Markku S Nieminen; Olle Melander; Veikko Salomaa; Leena Peltonen; Sekar Kathiresan
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
Lancet 2010;376(9750):1393-400.
2010: Kiran Musunuru; Alanna Strong; Maria Frank-Kamenetsky; Noemi E Lee; Tim Ahfeldt; Katherine V Sachs; Xiaoyu Li; Hui Li; Nicolas Kuperwasser; Vera M Ruda; James P Pirruccello; Brian Muchmore; Ludmila Prokunina-Olsson; Jennifer L Hall; Eric E Schadt; Carlos R Morales; Sissel Lund-Katz; Michael C Phillips; Jamie Wong; William Cantley; Timothy Racie; Kenechi G Ejebe; Marju Orho-Melander; Olle Melander; Victor Koteliansky; Kevin Fitzgerald; Ronald M Krauss; Chad A Cowan; Sekar Kathiresan; Daniel J Rader
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.
Nature 2010;466(7307):714-9.
2010: Riikka-Liisa Uronen; Per Lundmark; Marju Orho-Melander; Matti Jauhiainen; Kristina Larsson; Agneta Siegbahn; Lars Wallentin; Björn Zethelius; Olle Melander; Ann-Christine Syvänen; Elina Ikonen
Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(8):1614-20.
2010: Sofia Enhörning; Thomas J Wang; Peter M Nilsson; Peter Almgren; Bo Hedblad; Göran Berglund; Joachim Struck; Nils G. Morgenthaler; Andreas Bergmann; Eero Lindholm; Leif Groop; Valeriya Lyssenko; Marju Orho-Melander; Christopher Newton-Cheh; Olle Melander
Plasma copeptin and the risk of diabetes mellitus.
Circulation 2010;121(19):2102-8.
2010: Viktor Hamrefors; Marju Orho-Melander; Ronald M Krauss; Bo Hedblad; Peter Almgren; Göran Berglund; Olle Melander
A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.
Journal of lipid research 2010;51(3):625-34.
2009: Kiran Musunuru; Marju Orho-Melander; Michael P Caulfield; Shuguang Li; Wael A Salameh; Richard E Reitz; Göran Berglund; Bo Hedblad; Gunnar Engström; Paul T Williams; Sekar Kathiresan; Olle Melander; Ronald M Krauss
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1975-80.
2009: Emily Sonestedt; Charlotta Roos; Bo Gullberg; Ulrika Ericson; Elisabet Wirfält; Marju Orho-Melander
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.
The American journal of clinical nutrition 2009;90(5):1418-25.
2009: Nicola L Beer; Nicholas D Tribble; Laura J McCulloch; Charlotta Roos; Paul R V Johnson; Marju Orho-Melander; Anna L Gloyn
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
Human molecular genetics 2009;18(21):4081-8.
2009: Anna Kotronen; Markku Peltonen; Antti Hakkarainen; Ksenia Sevastianova; Robert Bergholm; Lina M Johansson; Nina Lundbom; Aila Rissanen; Martin Ridderstråle; Leif Groop; Marju Orho-Melander; Hannele Yki-Järvinen
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.
Gastroenterology 2009;137(3):865-72.
2009: Anna Kotronen; L E Johansson; L M Johansson; C Roos; Jukka Westerbacka; Anders Hamsten; Robert Bergholm; Perttu E T Arkkila; J Arola; Tuula Kiviluoto; Rachel M Fisher; Ewa Ehrenborg; Marju Orho-Melander; M Ridderstråle; Leif Groop; Hannele Yki-Järvinen
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.
Diabetologia 2009;52(6):1056-60.
2009: Björn Wahlstrand; Marju Orho-Melander; Lotta Delling; Sverre Kjeldsen; Krzysztof Narkiewicz; Peter Almgren; Thomas Hedner; Olle Melander
The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension.
Journal of hypertension 2009;27(4):769-73.
2009: Anna Kotronen; Hannele Yki-Järvinen; Anna Aminoff; Robert Bergholm; Kirsi H Pietiläinen; Jukka Westerbacka; Philippa J Talmud; Steve E Humphries; Anders Hamsten; Bo Isomaa; Leif Groop; Marju Orho-Melander; Ewa Ehrenborg; Rachel M Fisher
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):593-602.
2009: E Shyong Tai; Xue Ling Sim; Twee Hee Ong; Tien Yin Wong; Seang-Mei Saw; Tin Aung; Sekar Kathiresan; Marju Orho-Melander; Jose Ordovas; Jonathan T Tan; Mark Seielstad
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
Journal of lipid research 2009;50(3):514-20.
2009: Pablo Perez-Martinez; Dolores Corella; Jian Shen; Donna K Arnett; Nikos Yiannakouris; E Shyong Tai; Marju Orho-Melander; Katherine L Tucker; Michael Tsai; Robert J Straka; Michael A Province; Chew Suok Kai; Francisco Perez-Jimenez; Chao-Qiang Lai; Jose Lopez-Miranda; Marisa Guillen; Laurence D Parnell; Ingrid B Borecki; Sekar Kathiresan; Jose Ordovas
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.
The American journal of clinical nutrition 2009;89(1):391-9.
2008: Marketa Sjögren; Valeriya Lyssenko; A Jonsson; Göran Berglund; Peter Nilsson; Leif Groop; Marju Orho-Melander
The search for putative unifying genetic factors for components of the metabolic syndrome.
Diabetologia 2008;51(12):2242-51.
2008: Louise E Olofsson; Marju Orho-Melander; Lena William-Olsson; Kajsa Sjöholm; Lars Sjöström; Leif Groop; Björn Carlsson; Lena Carlsson; Bob Olsson
CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides.
The Journal of clinical endocrinology and metabolism 2008;93(12):4880-6.
2008: Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sørensen; David M Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot
A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
Molecular genetics and metabolism 2008;94(3):386-8.
2008: Sekar Kathiresan; Kiran Musunuru; Marju Orho-Melander
Defining the spectrum of alleles that contribute to blood lipid concentrations in humans.
Current opinion in lipidology 2008;19(2):122-7.
2008: Sekar Kathiresan; Olle Melander; Dragi Anevski; Candace Guiducci; Noël P Burtt; Charlotta Roos; Joel N Hirschhorn; Göran Berglund; Bo Hedblad; Leif Groop; David Altshuler; Christopher Newton-Cheh; Marju Orho-Melander
Polymorphisms associated with cholesterol and risk of cardiovascular events.
The New England journal of medicine 2008;358(12):1240-9.
2008: Sekar Kathiresan; Olle Melander; Candace Guiducci; Aarti Surti; Noël P Burtt; Mark J Rieder; Gregory Cooper; Charlotta Roos; Benjamin F Voight; Aki S Havulinna; Björn Wahlstrand; Thomas Hedner; Dolores Corella; E Shyong Tai; Jose Ordovas; Göran Berglund; Erkki Vartiainen; Pekka Jousilahti; Bo Hedblad; Marja-Riitta Taskinen; Christopher Newton-Cheh; Veikko Salomaa; Leena Peltonen; Leif Groop; David Altshuler; Marju Orho-Melander
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Nature genetics 2008;40(2):189-97.
2008: Leif Groop; Marju Orho-Melander
New insights into impaired muscle glycogen synthesis.
PLoS medicine 2008;5(1):e25.
2007: Valeriya Lyssenko; ROBERTO LUPI; Piero Marchetti; SILVIA DEL GUERRA; Marju Orho-Melander; Peter Almgren; Marketa Sjögren; Charlotte Ling; Karl-Fredrik Eriksson; Asa-Linda Lethagen; Rita Mancarella; Göran Berglund; Tiinamaija Tuomi; Peter Nilsson; Stefano Del Prato; Leif Groop
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
The Journal of clinical investigation 2007;117(8):2155-63.
2007: Sekar Kathiresan; Alisa K Manning; Serkalem Demissie; Ralph B D'Agostino; Aarti Surti; Candace Guiducci; Lauren Gianniny; Nöel P Burtt; Olle Melander; Marju Orho-Melander; Donna K Arnett; Gina M Peloso; Jose Ordovas; L Adrienne Cupples
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
BMC medical genetics 2007;8 Suppl 1():S17.
2007: Jenny Fredriksson; Dragi Anevski; Peter Almgren; Marketa Sjögren; Valeriya Lyssenko; Joyce Carlson; Bo Isomaa; Marja-Riitta Taskinen; Leif Groop; Marju Orho-Melander
Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.
PloS one 2007;2(3):e285.
2006: Richa Saxena; Lauren Gianniny; Noël P Burtt; Valeriya Lyssenko; Candace Giuducci; Marketa Sjögren; Jose C Florez; Peter Almgren; Bo Isomaa; Marju Orho-Melander; Ulf Lindblad; Mark J Daly; Tiinamaija Tuomi; Joel N Hirschhorn; Kristin G Ardlie; Leif C Groop; David Altshuler
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Diabetes 2006;55(10):2890-5.
2006: Jenny Fredriksson; Emma Carlsson; Marju Orho-Melander; Leif Groop; Martin Ridderstråle
A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects.
International journal of obesity (2005) 2006;30(2):226-32.
2006: Eero Lindholm; Olle Melander; Peter Almgren; Göran Berglund; Carl-David Agardh; Leif Groop; Marju Orho-Melander
Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
PloS one 2006;1():e64.
2005: Sampo Sammalisto; Tero Hiekkalinna; Elina Suviolahti; K Sood; A Metzidis; Päivi Pajukanta; Heidi E Lilja; Aino Soro-Paavonen; Marja-Riitta Taskinen; Tiinamaija Tuomi; Peter Almgren; Marju Orho-Melander; L Groop; Leena Peltonen; Markus Perola
A male-specific quantitative trait locus on 1p21 controlling human stature.
Journal of medical genetics 2005;42(12):932-9.
2005: Valeriya Lyssenko; Peter Almgren; Dragi Anevski; Marju Orho-Melander; Marketa Sjögren; Carola Saloranta; Tiinamaija Tuomi; Leif Groop
Genetic prediction of future type 2 diabetes.
PLoS medicine 2005;2(12):e345.
2004: Jose C Florez; Marketa Sjögren; Noël P Burtt; Marju Orho-Melander; Steve Schayer; Maria Sun; Peter Almgren; Ulf Lindblad; Tiinamaija Tuomi; Daniel Gaudet; Thomas J Hudson; Mark J Daly; Kristin G Ardlie; Joel N Hirschhorn; David Altshuler; Leif Groop
Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.
Diabetes 2004;53(12):3313-8.
2004: Sara H Bengtsson-Ellmark; Jeanette Nilsson; Marju Orho-Melander; Kerstin Dahlenborg; Leif Groop; Gunnar Bjursell
Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile.
European journal of human genetics : EJHG 2004;12(8):627-32.
2004: Devjit Tripathy; Karl-Fredrik Eriksson; Marju Orho-Melander; Jenny Fredriksson; G Ahlqvist; Leif Groop
Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
Diabetologia 2004;47(5):782-93.
2004: Jenny Fredriksson; Martin Ridderstråle; Leif Groop; Marju Orho-Melander
Characterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
European journal of clinical investigation 2004;34(2):113-21.
2003: Amir Snapir; Mika Scheinin; Leif C Groop; Marju Orho-Melander
The insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes.
Cardiovascular diabetology 2003;2():15.
2003: Elina Suviolahti; Martin Ridderstråle; Peter Almgren; Mia Klannemark; Olle Melander; Emma Carlsson; M Carlsson; Jan Hedenbro; Marju Orho-Melander
Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(10):1204-11.
2003: Fredrik von Wowern; Kristina Bengtsson; Cecilia M Lindgren; Marju Orho-Melander; Frej Fyhrquist; Ulf Lindblad; Lennart Råstam; Carol Forsblom; Timo Kanninen; Peter Almgren; Philippe Burri; Per Katzman; Leif Groop; U Lennart Hulthén; Olle Melander
A genome wide scan for early onset primary hypertension in Scandinavians.
Human molecular genetics 2003;12(16):2077-81.
2003: Amir Snapir; Juha W Koskenvuo; Jyri O Toikka; Marju Orho-Melander; Susanna Hinkka; Markku Saraste; Jaakko Hartiala; Mika Scheinin
Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline.
Clinical science (London, England : 1979) 2003;104(5):509-20.
2002: Camilla Cervin; Marju Orho-Melander; Martin Ridderstråle; Markku Lehto; Sebastian Barg; Leif Groop; Corrado M Cilio
Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
Diabetologia 2002;45(12):1703-8.
2002: Marju Orho-Melander; Mia Klannemark; Malin K Svensson; Martin Ridderstråle; Cecilia M Lindgren; Leif Groop
Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
Diabetes 2002;51(8):2658-64.
2002: Bert E Bachrach; David A Weinstein; Marju Orho-Melander; Anne Burgess; Joseph I Wolfsdorf
Glycogen synthase deficiency (glycogen storage disease type 0) presenting with hyperglycemia and glucosuria: report of three new mutations.
The Journal of pediatrics 2002;140(6):781-3.
2001: Cecilia M Lindgren; A Nilsson; Marju Orho-Melander; Peter Almgren; Leif C Groop
Characterization of the annexin I gene and evaluation of its role in type 2 diabetes.
Diabetes 2001;50(10):2402-5.
2001: Leif Groop; Marju Orho-Melander
The dysmetabolic syndrome.
Journal of internal medicine 2001;250(2):105-20.
2001: Kristina Bengtsson; Olle Melander; Marju Orho-Melander; Ulf Lindblad; Jonas Ranstam; Lennart Råstam; Leif Groop
Polymorphism in the beta(1)-adrenergic receptor gene and hypertension.
Circulation 2001;104(2):187-90.
2001: M Carlsson; Marju Orho-Melander; Jan Hedenbro; Leif C Groop
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.
Diabetologia 2001;44(5):629-36.
2001: Kristina Bengtsson; Marju Orho-Melander; Olle Melander; Ulf Lindblad; Jonas Ranstam; Lennart Råstam; Leif Groop
Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes.
Hypertension 2001;37(5):1303-8.
2001: A Parker; J Meyer; Steve Lewitzky; J S Rennich; G Chan; J D Thomas; Marju Orho-Melander; Mikko Lehtovirta; Carol Forsblom; A Hyrkkö; M Carlsson; Cecilia M Lindgren; Leif C Groop
A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11.
Diabetes 2001;50(3):675-80.
2000: Olle Melander; Marju Orho-Melander; Kristina Bengtsson; Ulf Lindblad; Lennart Råstam; Leif Groop; U Lennart Hulthén
Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension.
Journal of human hypertension 2000;14(12):819-23.
2000: Olle Melander; Marju Orho-Melander; Kristina Bengtsson; Ulf Lindblad; L Râstam; Leif Groop; U Lennart Hulthén
Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension.
Hypertension 2000;36(3):389-94.
2000: Mia Klannemark; L Suurinkeroinen; Marju Orho-Melander; Leif Groop; Marja-Riitta Taskinen
Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(8):599-605.
2000: M Carlsson; Marju Orho-Melander; Jan Hedenbro; Peter Almgren; Leif C Groop
The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke.
The Journal of clinical endocrinology and metabolism 2000;85(8):2801-4.
2000: Olle Melander; Kristina Bengtsson; Marju Orho-Melander; Ulf Lindblad; Carol Forsblom; Lennart Råstam; Leif Groop; U Lennart Hulthén
Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians.
Journal of human hypertension 2000;14(1):43-6.
2000: K I Papadopoulos; Olle Melander; Marju Orho-Melander; Leif C Groop; M Carlsson; B Hallengren
Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases.
Journal of internal medicine 2000;247(1):71-7.
1999: Kristina Bengtsson; Marju Orho-Melander; Ulf Lindblad; Olle Melander; Erik Bøg-Hansen; Jonas Ranstam; Lennart Råstam; Leif Groop
Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project.
Journal of hypertension 1999;17(11):1569-75.
1999: Marju Orho-Melander; Peter Almgren; Timo Kanninen; Carol Forsblom; Leif C Groop
A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene.
Diabetologia 1999;42(9):1138-45.
1999: Marju Orho-Melander; H Shimomura; T Sanke; S K Rasmussen; K Nanjo; Oluf Pedersen; Leif C Groop
Expression of naturally occurring variants in the muscle glycogen synthase gene.
Diabetes 1999;48(4):918-20.