Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Stuart Orkin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Mice

Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Physiology

Anatomy

Hematopoietic Stem Cells

Disorders

Thalassemia

Genes & Molecular Sequences

Procedures

Molecular Cloning

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
23
Nathan, David
19
Zon, Leonard
12
Shivdasani, Ramesh
12
Dinauer, Mary
11
Kazazian, Haig
11
Mikkola, Hanna
10
Fujiwara, Yuko
10
Ginsburg, David
9
Fujiwara, Yuko
7
Boehm, Corinne
7
Kim, Jonghwan
6
Fujiwara, Y
5
Bronson, Roderick
5
Crispino, John
5
Hock, Hanno

Sign-in to see all Coauthors

Publications

TOP 3
Trowbridge Jennifer J; Snow Jonathan W; Kim Jonghwan; Orkin Stuart H
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.
Snow Jonathan W; Orkin Stuart H
Translational isoforms of FOG1 regulate GATA1-interacting complexes.
Huang Zan; Dore Louis C; Li Zhe; Orkin Stuart H; Feng Gang; Lin Simon; Crispino John D
GATA-2 reinforces megakaryocyte development in the absence of GATA-1.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Stuart Orkin (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Trowbridge Jennifer J; Snow Jonathan W; Kim Jonghwan; Orkin Stuart H
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.
Cell stem cell 2009;5(4):442-9.
2009: Snow Jonathan W; Orkin Stuart H
Translational isoforms of FOG1 regulate GATA1-interacting complexes.
The Journal of biological chemistry 2009;284(43):29310-9.
2009: Huang Zan; Dore Louis C; Li Zhe; Orkin Stuart H; Feng Gang; Lin Simon; Crispino John D
GATA-2 reinforces megakaryocyte development in the absence of GATA-1.
Molecular and cellular biology 2009;29(18):5168-80.
2009: Sankaran Vijay G; Xu Jian; Ragoczy Tobias; Ippolito Gregory C; Walkley Carl R; Maika Shanna D; Fujiwara Yuko; Ito Masafumi; Groudine Mark; Bender M A; Tucker Philip W; Orkin Stuart H
Developmental and species-divergent globin switching are driven by BCL11A.
Nature 2009;460(7259):1093-7.
2009: Schindler Jeffrey W; Van Buren Denille; Foudi Adlen; Krejci Ondrej; Qin Jinzhong; Orkin Stuart H; Hock Hanno
TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia.
Cell stem cell 2009;5(1):43-53.
2009: Hu Guang; Kim Jonghwan; Xu Qikai; Leng Yumei; Orkin Stuart H; Elledge Stephen J
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.
Genes & development 2009;23(7):837-48.
2009: Gekas Christos; Rhodes Katrin E; Gereige Laurraine M; Helgadottir Hildur; Ferrari Roberto; Kurdistani Siavash K; Montecino-Rodriguez Encarnación; Bassel-Duby Rhonda; Olson Eric; Krivtsov Andrei V; Armstrong Scott; Orkin Stuart H; Pellegrini Matteo; Mikkola Hanna K A
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood 2009;113(15):3461-71.
2009: Wang Jianlong; Cantor Alan B; Orkin Stuart H
Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation.
Current protocols in stem cell biology 2009;Chapter 1():Unit1B.5.
2009: Shen Xiaohua; Orkin Stuart H
Glimpses of the epigenetic landscape.
Cell stem cell 2009;4(1):1-2.
2009: Nathan David G; Orkin Stuart H
Musings on genome medicine: the Obama effect redux.
Genome medicine 2009;1(9):86.
2009: Nathan David G; Orkin Stuart H
Musings on genome medicine: cholesterol and coronary artery disease.
Genome medicine 2009;1(6):60.
2009: Nathan David G; Orkin Stuart H
Musings on genome medicine: cancer genetics and the promise of effective treatment.
Genome medicine 2009;1(5):49.
2009: Nathan David G; Orkin Stuart H
Musings on genome medicine: gene therapy.
Genome medicine 2009;1(4):38.
2009: Kim Jonghwan; Cantor Alan B; Orkin Stuart H; Wang Jianlong
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells.
Nature protocols 2009;4(4):506-17.
2008: Shen Xiaohua; Liu Yingchun; Hsu Yu-Jung; Fujiwara Yuko; Kim Jonghwan; Mao Xiaohong; Yuan Guo-Cheng; Orkin Stuart H
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
Molecular cell 2008;32(4):491-502.
2008: Terranova Rémi; Yokobayashi Shihori; Stadler Michael B; Otte Arie P; van Lohuizen Maarten; Orkin Stuart H; Peters Antoine H F M
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.
Developmental cell 2008;15(5):668-79.
2008: Beuling Eva; Bosse Tjalling; aan de Kerk Daniel J; Piaseckyj Christina M; Fujiwara Yuko; Katz Samuel G; Orkin Stuart H; Grand Richard J; Krasinski Stephen D
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.
Developmental biology 2008;322(1):179-89.
2008: Lettre Guillaume; Sankaran Vijay G; Bezerra Marcos André C; Araújo Aderson S; Uda Manuela; Sanna Serena; Cao Antonio; Schlessinger David; Costa Fernando F; Hirschhorn Joel N; Orkin Stuart H
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11869-74.
2008: Walkley Carl R; Qudsi Rameez; Sankaran Vijay G; Perry Jennifer A; Gostissa Monica; Roth Sanford I; Rodda Stephen J; Snay Erin; Dunning Patricia; Fahey Frederic H; Alt Frederick W; McMahon Andrew P; Orkin Stuart H
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.
Genes & development 2008;22(12):1662-76.
2008: Sue Nancy; Jack Briony H A; Eaton Sally A; Pearson Richard C M; Funnell Alister P W; Turner Jeremy; Czolij Robert; Denyer Gareth; Bao Shisan; Molero-Navajas Juan Carlos; Perkins Andrew; Fujiwara Yuko; Orkin Stuart H; Bell-Anderson Kim; Crossley Merlin
Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
Molecular and cellular biology 2008;28(12):3967-78.
2008: Wang Jianlong; Levasseur Dana N; Orkin Stuart H
Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6326-31.
2008: Puschendorf Mareike; Terranova Rémi; Boutsma Erwin; Mao Xiaohong; Isono Kyo-ichi; Brykczynska Urszula; Kolb Carolin; Otte Arie P; Koseki Haruhiko; Orkin Stuart H; van Lohuizen Maarten; Peters Antoine H F M
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Nature genetics 2008;40(4):411-20.
2008: Rhodes Katrin E; Gekas Christos; Wang Yanling; Lux Christopher T; Francis Cameron S; Chan David N; Conway Simon; Orkin Stuart H; Yoder Mervin C; Mikkola Hanna K A
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation.
Cell stem cell 2008;2(3):252-63.
2008: Kim Jonghwan; Chu Jianlin; Shen Xiaohua; Wang Jianlong; Orkin Stuart H
An extended transcriptional network for pluripotency of embryonic stem cells.
Cell 2008;132(6):1049-61.
2008: Cantor Alan B; Iwasaki Hiromi; Arinobu Yojiro; Moran Tyler B; Shigematsu Hirokazu; Sullivan Matthew R; Akashi Koichi; Orkin Stuart H
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage.
The Journal of experimental medicine 2008;205(3):611-24.
2008: Levasseur Dana N; Wang Jianlong; Dorschner Michael O; Stamatoyannopoulos John A; Orkin Stuart H
Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.
Genes & development 2008;22(5):575-80.
2008: Orkin Stuart H; Zon Leonard I
SnapShot: hematopoiesis.
Cell 2008;132(4):712.
2008: Orkin Stuart H; Zon Leonard I
Hematopoiesis: an evolving paradigm for stem cell biology.
Cell 2008;132(4):631-44.
2008: Sankaran Vijay G; Orkin Stuart H; Walkley Carl R
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis.
Genes & development 2008;22(4):463-75.
2008: Uda Manuela; Galanello Renzo; Sanna Serena; Lettre Guillaume; Sankaran Vijay G; Chen Weimin; Usala Gianluca; Busonero Fabio; Maschio Andrea; Albai Giuseppe; Piras Maria Grazia; Sestu Natascia; Lai Sandra; Dei Mariano; Mulas Antonella; Crisponi Laura; Naitza Silvia; Asunis Isadora; Deiana Manila; Nagaraja Ramaiah; Perseu Lucia; Satta Stefania; Cipollina Maria Dolores; Sollaino Carla; Moi Paolo; Hirschhorn Joel N; Orkin Stuart H; Abecasis Gonçalo R; Schlessinger David; Cao Antonio
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1620-5.
2008: Orkin S H; Wang J; Kim J; Chu J; Rao S; Theunissen T W; Shen X; Levasseur D N
The transcriptional network controlling pluripotency in ES cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():195-202.
2008: Walkley Carl R; Sankaran Vijay G; Orkin Stuart H
Rb and hematopoiesis: stem cells to anemia.
Cell division 2008;3():13.
2008: Wang Jianlong; Orkin Stuart H
A protein roadmap to pluripotency and faithful reprogramming.
Cells, tissues, organs 2008;188(1-2):23-30.
2007: Wang Jianlong; Theunissen Thorold W; Orkin Stuart H
Site-directed, virus-free, and inducible RNAi in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20850-5.
2007: Li Zhe; Tognon Cristina E; Godinho Frank J; Yasaitis Laura; Hock Hanno; Herschkowitz Jason I; Lannon Chris L; Cho Eunah; Kim Seong-Jin; Bronson Roderick T; Perou Charles M; Sorensen Poul H; Orkin Stuart H
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.
Cancer cell 2007;12(6):542-58.
2007: Orkin Stuart H; Pera Martin
Stem cells down under-ISSCR 2007.
Cell stem cell 2007;1(3):271-6.
2007: Xie Huafeng; Orkin Stuart H
Immunology: changed destiny.
Nature 2007;449(7161):410-1.
2007: Saleque Shireen; Kim Jonghwan; Rooke Heather M; Orkin Stuart H
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.
Molecular cell 2007;27(4):562-72.
2007: North Trista E; Goessling Wolfram; Walkley Carl R; Lengerke Claudia; Kopani Kamden R; Lord Allegra M; Weber Gerhard J; Bowman Teresa V; Jang Il-Ho; Grosser Tilo; Fitzgerald Garret A; Daley George Q; Orkin Stuart H; Zon Leonard I
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
Nature 2007;447(7147):1007-11.
2007: Walkley Carl R; Shea Jeremy M; Sims Natalie A; Purton Louise E; Orkin Stuart H
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.
Cell 2007;129(6):1081-95.
2007: Ackerman Kate G; Wang Jianlong; Luo Liqing; Fujiwara Yuko; Orkin Stuart H; Beier David R
Gata4 is necessary for normal pulmonary lobar development.
American journal of respiratory cell and molecular biology 2007;36(4):391-7.
2007: Ghinassi Barbara; Sanchez Massimo; Martelli Fabrizio; Amabile Giovanni; Vannucchi Alessandro Maria; Migliaccio Giovanni; Orkin Stuart H; Migliaccio Anna Rita
The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor.
Blood 2007;109(4):1460-71.
2006: Wu Sean M; Fujiwara Yuko; Cibulsky Susan M; Clapham David E; Lien Ching-Ling; Schultheiss Thomas M; Orkin Stuart H
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
Cell 2006;127(6):1137-50.
2006: Wang Jianlong; Rao Sridhar; Chu Jianlin; Shen Xiaohua; Levasseur Dana N; Theunissen Thorold W; Orkin Stuart H
A protein interaction network for pluripotency of embryonic stem cells.
Nature 2006;444(7117):364-8.
2006: Mikkola Hanna K A; Orkin Stuart H
The journey of developing hematopoietic stem cells.
Development (Cambridge, England) 2006;133(19):3733-44.
2006: Walkley Carl R; Orkin Stuart H
Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9057-62.
2006: de Pooter Renée F; Schmitt Thomas M; de la Pompa José Luis; Fujiwara Yuko; Orkin Stuart H; Zúñiga-Pflücker Juan Carlos
Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5267-75.
2006: Guyot Boris; Murai Kasumi; Fujiwara Yuko; Valverde-Garduno Veronica; Hammett Michele; Wells Sara; Dear Neil; Orkin Stuart H; Porcher Catherine; Vyas Paresh
Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1.
The Journal of biological chemistry 2006;281(19):13733-42.
2006: Rooke Heather M; Orkin Stuart H
Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo.
Blood 2006;107(9):3527-30.
2006: Bourquin Jean-Pierre; Subramanian Aravind; Langebrake Claudia; Reinhardt Dirk; Bernard Olivier; Ballerini Paola; Baruchel André; Cavé Hélène; Dastugue Nicole; Hasle Henrik; Kaspers Gertjan L; Lessard Michel; Michaux Lucienne; Vyas Paresh; van Wering Elisabeth; Zwaan Christian M; Golub Todd R; Orkin Stuart H
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3339-44.
2006: Orkin Stuart H
Reactions to the Hwang scandal.
Science (New York, N.Y.) 2006;311(5761):606-7.
2006: Hock Hanno; Orkin Stuart H
Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells.
Current opinion in hematology 2006;13(1):1-6.
2006: Rao Sridhar; Orkin Stuart H
Unraveling the transcriptional network controlling ES cell pluripotency.
Genome biology 2006;7(8):230.
2005: Muroyama Yuko; Fujiwara Yuko; Orkin Stuart H; Rowitch David H
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube.
Nature 2005;438(7066):360-3.
2005: Orkin Stuart H
Chipping away at the embryonic stem cell network.
Cell 2005;122(6):828-30.
2005: Mikkola Hanna K A; Gekas Christos; Orkin Stuart H; Dieterlen-Lievre Francoise
Placenta as a site for hematopoietic stem cell development.
Experimental hematology 2005;33(9):1048-54.
2005: Kadri Zahra; Maouche-Chretien Leila; Rooke Heather M; Orkin Stuart H; Romeo Paul-Henri; Mayeux Patrick; Leboulch Philippe; Chretien Stany
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.
Molecular and cellular biology 2005;25(17):7412-22.
2005: Tsai Judy; Tong Qiang; Tan Guo; Chang Aaron N; Orkin Stuart H; Hotamisligil Gökhan S
The transcription factor GATA2 regulates differentiation of brown adipocytes.
EMBO reports 2005;6(9):879-84.
2005: Rodrigues Neil P; Janzen Viktor; Forkert Randolf; Dombkowski David M; Boyd Ashleigh S; Orkin Stuart H; Enver Tariq; Vyas Paresh; Scadden David T
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.
Blood 2005;106(2):477-84.
2005: Hock Hanno; Orkin Stuart H
Stem cells: the road not taken.
Nature 2005;435(7042):573-5.
2005: Li Zhe; Godinho Frank J; Klusmann Jan-Henning; Garriga-Canut Mireia; Yu Channing; Orkin Stuart H
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1.
Nature genetics 2005;37(6):613-9.
2005: Sun Tao; Patoine Christina; Abu-Khalil Amir; Visvader Jane; Sum Eleanor; Cherry Timothy J; Orkin Stuart H; Geschwind Daniel H; Walsh Christopher A
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Science (New York, N.Y.) 2005;308(5729):1794-8.
2005: Schlaeger Thorsten M; Mikkola Hanna K A; Gekas Christos; Helgadottir Hildur B; Orkin Stuart H
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.
Blood 2005;105(10):3871-4.
2005: Gekas Christos; Dieterlen-Lièvre Francoise; Orkin Stuart H; Mikkola Hanna K A
The placenta is a niche for hematopoietic stem cells.
Developmental cell 2005;8(3):365-75.
2005: Cantor Alan B; Orkin Stuart H
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins.
Seminars in cell & developmental biology 2005;16(1):117-28.
2005: Tsuneto Motokazu; Tominaga Akira; Yamazaki Hidetoshi; Yoshino Miya; Orkin Stuart H; Hayashi Shin-Ichi
Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1.
Stem cells (Dayton, Ohio) 2005;23(1):134-43.
2005: Mikkola Hanna K A; Orkin Stuart H
Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse.
Methods in molecular medicine 2005;105():3-22.
2004: Rual Jean-François; Ceron Julian; Koreth John; Hao Tong; Nicot Anne-Sophie; Hirozane-Kishikawa Tomoko; Vandenhaute Jean; Orkin Stuart H; Hill David E; van den Heuvel Sander; Vidal Marc
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.
Genome research 2004;14(10B):2162-8.
2004: Ling Kam-Wing; Ottersbach Katrin; van Hamburg Jan Piet; Oziemlak Aneta; Tsai Fong-Ying; Orkin Stuart H; Ploemacher Rob; Hendriks Rudi W; Dzierzak Elaine
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.
The Journal of experimental medicine 2004;200(7):871-82.
2004: Hock Hanno; Hamblen Melanie J; Rooke Heather M; Schindler Jeffrey W; Saleque Shireen; Fujiwara Yuko; Orkin Stuart H
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.
Nature 2004;431(7011):1002-7.
2004: Hock Hanno; Meade Eliza; Medeiros Sarah; Schindler Jeffrey W; Valk Peter J M; Fujiwara Yuko; Orkin Stuart H
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.
Genes & development 2004;18(19):2336-41.
2004: Humbles Alison A; Lloyd Clare M; McMillan Sarah J; Friend Daniel S; Xanthou Georgina; McKenna Erin E; Ghiran Sorina; Gerard Norma P; Yu Channing; Orkin Stuart H; Gerard Craig
A critical role for eosinophils in allergic airways remodeling.
Science (New York, N.Y.) 2004;305(5691):1776-9.
2004: Schlaeger Thorsten M; Schuh Anna; Flitter Simon; Fisher Andreas; Mikkola Hanna; Orkin Stuart H; Vyas Paresh; Porcher Catherine
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
Molecular and cellular biology 2004;24(17):7491-502.
2004: Ransom David G; Bahary Nathan; Niss Knut; Traver David; Burns Caroline; Trede Nikolaus S; Paffett-Lugassy Noelle; Saganic Walter J; Lim C Anthoney; Hersey Candace; Zhou Yi; Barut Bruce A; Lin Shuo; Kingsley Paul D; Palis James; Orkin Stuart H; Zon Leonard I
The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.
PLoS biology 2004;2(8):E237.
2004: Garriga-Canut Mireia; Orkin Stuart H
Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis.
The Journal of biological chemistry 2004;279(22):23597-605.
2004: Tuveson David A; Shaw Alice T; Willis Nicholas A; Silver Daniel P; Jackson Erica L; Chang Sandy; Mercer Kim L; Grochow Rebecca; Hock Hanno; Crowley Denise; Hingorani Sunil R; Zaks Tal; King Catrina; Jacobetz Michael A; Wang Lifu; Bronson Roderick T; Orkin Stuart H; DePinho Ronald A; Jacks Tyler
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Cancer cell 2004;5(4):375-87.
2004: Hahm Kyungmin; Sum Eleanor Y M; Fujiwara Yuko; Lindeman Geoffrey J; Visvader Jane E; Orkin Stuart H
Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1.
Molecular and cellular biology 2004;24(5):2074-82.
2004: Roberts Charles W M; Orkin Stuart H
The SWI/SNF complex--chromatin and cancer.
Nature reviews. Cancer 2004;4(2):133-42.
2004: Smith Erica D; Xu Yanfei; Tomson Brett N; Leung Cindy G; Fujiwara Yuko; Orkin Stuart H; Crispino John D
More than blood, a novel gene required for mammalian postimplantation development.
Molecular and cellular biology 2004;24(3):1168-73.
2004: Pal Saumen; Cantor Alan B; Johnson Kirby D; Moran Tyler B; Boyer Meghan E; Orkin Stuart H; Bresnick Emery H
Coregulator-dependent facilitation of chromatin occupancy by GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):980-5.
2004: Fujiwara Yuko; Chang Aaron N; Williams Aimee M; Orkin Stuart H
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development.
Blood 2004;103(2):583-5.
2003: Orkin Stuart H
Priming the hematopoietic pump.
Immunity 2003;19(5):633-4.
2003: Katz Samuel G; Williams Aimee; Yang Jifu; Fujiwara Yuko; Tsang Alice P; Epstein Jonathan A; Orkin Stuart H
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14030-5.
2003: Fossett Nancy; Hyman Kristy; Gajewski Kathleen; Orkin Stuart H; Schulz Robert A
Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11451-6.
2003: Neumann Carola A; Krause Daniela S; Carman Christopher V; Das Shampa; Dubey Devendra P; Abraham Jennifer L; Bronson Roderick T; Fujiwara Yuko; Orkin Stuart H; Van Etten Richard A
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Nature 2003;424(6948):561-5.
2003: Ema Masatsugu; Faloon Patrick; Zhang Wen Jie; Hirashima Masanori; Reid Tammy; Stanford William L; Orkin Stuart; Choi Kyunghee; Rossant Janet
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse.
Genes & development 2003;17(3):380-93.
2003: Migliaccio Anna Rita; Rana Rosa Alba; Sanchez Massimo; Lorenzini Rodolfo; Centurione Lucia; Bianchi Lucia; Vannucchi Alessandro Maria; Migliaccio Giovanni; Orkin Stuart H
GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant.
The Journal of experimental medicine 2003;197(3):281-96.
2003: Mikkola Hanna K A; Klintman Jenny; Yang Haidi; Hock Hanno; Schlaeger Thorsten M; Fujiwara Yuko; Orkin Stuart H
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.
Nature 2003;421(6922):547-51.
2003: Hock Hanno; Hamblen Melanie J; Rooke Heather M; Traver David; Bronson Roderick T; Cameron Scott; Orkin Stuart H
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.
Immunity 2003;18(1):109-20.
2003: Wallis Deeann; Hamblen Melanie; Zhou Yi; Venken Koen J T; Schumacher Armin; Grimes H Leighton; Zoghbi Huda Y; Orkin Stuart H; Bellen Hugo J
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.
Development (Cambridge, England) 2003;130(1):221-32.
2003: Mikkola Hanna K A; Fujiwara Yuko; Schlaeger Thorsten M; Traver David; Orkin Stuart H
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.
Blood 2003;101(2):508-16.
2002: Endoh Mitsuhiro; Ogawa Minetaro; Orkin Stuart; Nishikawa Shin-ichi
SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation.
The EMBO journal 2002;21(24):6700-8.
2002: Roberts Charles W M; Leroux Monique M; Fleming Mark D; Orkin Stuart H
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.
Cancer cell 2002;2(5):415-25.
2002: Lécuyer Eric; Herblot Sabine; Saint-Denis Marianne; Martin Richard; Begley C Glenn; Porcher Catherine; Orkin Stuart H; Hoang Trang
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
Blood 2002;100(7):2430-40.
2002: Tevosian Sergei G; Albrecht Kenneth H; Crispino John D; Fujiwara Yuko; Eicher Eva M; Orkin Stuart H
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Development (Cambridge, England) 2002;129(19):4627-34.
2002: Ritchie Kenneth J; Malakhov Michael P; Hetherington Christopher J; Zhou Liming; Little Marie-Terese; Malakhova Oxana A; Sipe Jack C; Orkin Stuart H; Zhang Dong-Er
Dysregulation of protein modification by ISG15 results in brain cell injury.
Genes & development 2002;16(17):2207-12.
2002: Yu Channing; Niakan Kathy K; Matsushita Mark; Stamatoyannopoulos George; Orkin Stuart H; Raskind Wendy H
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.
Blood 2002;100(6):2040-5.
2002: Orkin Stuart H; Morrison Sean J
Stem-cell competition.
Nature 2002;418(6893):25-7.
2002: Chang Aaron N; Cantor Alan B; Fujiwara Yuko; Lodish Maya B; Droho Steven; Crispino John D; Orkin Stuart H
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9237-42.
2002: Yu Channing; Cantor Alan B; Yang Haidi; Browne Carol; Wells Richard A; Fujiwara Yuko; Orkin Stuart H
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo.
The Journal of experimental medicine 2002;195(11):1387-95.
2002: Cantor Alan B; Katz Samuel G; Orkin Stuart H
Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation.
Molecular and cellular biology 2002;22(12):4268-79.
2002: Cantor Alan B; Orkin Stuart H
Transcriptional regulation of erythropoiesis: an affair involving multiple partners.
Oncogene 2002;21(21):3368-76.
2002: Katz Samuel G; Cantor Alan B; Orkin Stuart H
Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.
Molecular and cellular biology 2002;22(9):3121-8.
2002: Orkin Stuart H; Zon Leonard I
Hematopoiesis and stem cells: plasticity versus developmental heterogeneity.
Nature immunology 2002;3(4):323-8.
2002: Mikkola Hanna K A; Orkin Stuart H
The search for the hemangioblast.
Journal of hematotherapy & stem cell research 2002;11(1):9-17.
2002: Saleque Shireen; Cameron Scott; Orkin Stuart H
The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.
Genes & development 2002;16(3):301-6.
2002: Crispino John D; Orkin Stuart H
The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes.
Methods (San Diego, Calif.) 2002;26(1):84-92.
2001: Murga M; Fernández-Capetillo O; Field S J; Moreno B; Borlado L R; Fujiwara Y; Balomenos D; Vicario A; Carrera A C; Orkin S H; Greenberg M E; Zubiaga A M
Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity.
Immunity 2001;15(6):959-70.
2001: Han A P; Yu C; Lu L; Fujiwara Y; Browne C; Chin G; Fleming M; Leboulch P; Orkin S H; Chen J J
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.
The EMBO journal 2001;20(23):6909-18.
2001: Zhu J W; Field S J; Gore L; Thompson M; Yang H; Fujiwara Y; Cardiff R D; Greenberg M; Orkin S H; DeGregori J
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
Molecular and cellular biology 2001;21(24):8547-64.
2001: Wu L; Timmers C; Maiti B; Saavedra H I; Sang L; Chong G T; Nuckolls F; Giangrande P; Wright F A; Field S J; Greenberg M E; Orkin S; Nevins J R; Robinson M L; Leone G
The E2F1-3 transcription factors are essential for cellular proliferation.
Nature 2001;414(6862):457-62.
2001: Zhou M; Ouyang W; Gong Q; Katz S G; White J M; Orkin S H; Murphy K M
Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.
The Journal of experimental medicine 2001;194(10):1461-71.
2001: Jasinski M; Keller P; Fujiwara Y; Orkin S H; Bessler M
GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells).
Blood 2001;98(7):2248-55.
2001: Cantor A B; Orkin S H
Hematopoietic development: a balancing act.
Current opinion in genetics & development 2001;11(5):513-9.
2001: Leone G; Sears R; Huang E; Rempel R; Nuckolls F; Park C H; Giangrande P; Wu L; Saavedra H I; Field S J; Thompson M A; Yang H; Fujiwara Y; Greenberg M E; Orkin S; Smith C; Nevins J R
Myc requires distinct E2F activities to induce S phase and apoptosis.
Molecular cell 2001;8(1):105-13.
2001: Mead P E; Deconinck A E; Huber T L; Orkin S H; Zon L I
Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins.
Development (Cambridge, England) 2001;128(12):2301-8.
2001: Fossett N; Tevosian S G; Gajewski K; Zhang Q; Orkin S H; Schulz R A
The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7342-7.
2001: Crispino J D; Lodish M B; Thurberg B L; Litovsky S H; Collins T; Molkentin J D; Orkin S H
Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.
Genes & development 2001;15(7):839-44.
2001: Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin S H
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain.
Blood 2001;97(1):324-6.
2000: Roberts C W; Galusha S A; McMenamin M E; Fletcher C D; Orkin S H
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13796-800.
2000: Vyas P; Norris F A; Joseph R; Majerus P W; Orkin S H
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13696-701.
2000: Orkin S H
Stem cell alchemy.
Nature medicine 2000;6(11):1212-3.
2000: Kappel A; Schlaeger T M; Flamme I; Orkin S H; Risau W; Breier G
Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.
Blood 2000;96(9):3078-85.
2000: Orkin S H
Diversification of haematopoietic stem cells to specific lineages.
Nature reviews. Genetics 2000;1(1):57-64.
2000: Zhang P; Zhang X; Iwama A; Yu C; Smith K A; Mueller B U; Narravula S; Torbett B E; Orkin S H; Tenen D G
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
Blood 2000;96(8):2641-8.
2000: Querfurth E; Schuster M; Kulessa H; Crispino J D; Döderlein G; Orkin S H; Graf T; Nerlov C
Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.
Genes & development 2000;14(19):2515-25.
2000: Yamane T; Kunisada T; Yamazaki H; Nakano T; Orkin S H; Hayashi S I
Sequential requirements for SCL/tal-1, GATA-2, macrophage colony-stimulating factor, and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development.
Experimental hematology 2000;28(7):833-40.
2000: Chen F; Ma L; Parrini M C; Mao X; Lopez M; Wu C; Marks P W; Davidson L; Kwiatkowski D J; Kirchhausen T; Orkin S H; Rosen F S; Mayer B J; Kirschner M W; Alt F W
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Current biology : CB 2000;10(13):758-65.
2000: Tevosian S G; Deconinck A E; Tanaka M; Schinke M; Litovsky S H; Izumo S; Fujiwara Y; Orkin S H
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Cell 2000;101(7):729-39.
2000: Lewis B A; Kim T K; Orkin S H
A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7172-7.
2000: Shirihai O S; Gregory T; Yu C; Orkin S H; Weiss M J
ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
The EMBO journal 2000;19(11):2492-502.
2000: Deconinck A E; Mead P E; Tevosian S G; Crispino J D; Katz S G; Zon L I; Orkin S H
FOG acts as a repressor of red blood cell development in Xenopus.
Development (Cambridge, England) 2000;127(10):2031-40.
2000: Faloon P; Arentson E; Kazarov A; Deng C X; Porcher C; Orkin S; Choi K
Basic fibroblast growth factor positively regulates hematopoietic development.
Development (Cambridge, England) 2000;127(9):1931-41.
2000: Nichols K E; Crispino J D; Poncz M; White J G; Orkin S H; Maris J M; Weiss M J
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.
Nature genetics 2000;24(3):266-70.
2000: Perkins A C; Peterson K R; Stamatoyannopoulos G; Witkowska H E; Orkin S H
Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos.
Blood 2000;95(5):1827-33.
2000: Reimold A M; Etkin A; Clauss I; Perkins A; Friend D S; Zhang J; Horton H F; Scott A; Orkin S H; Byrne M C; Grusby M J; Glimcher L H
An essential role in liver development for transcription factor XBP-1.
Genes & development 2000;14(2):152-7.
1999: Porcher C; Liao E C; Fujiwara Y; Zon L I; Orkin S H
Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.
Development (Cambridge, England) 1999;126(20):4603-15.
1999: Orkin S H; Weiss M J
Apoptosis. Cutting red-cell production.
Nature 1999;401(6752):433, 435-6.
1999: Alberts B M; Ayala F J; Botstein D; Frank E; Holmes E W; Lee R D; Macagno E R; Marrack P; Oparil S; Orkin S H; Rubenstein A H; Slayman C W; Sparling P F; Squire L R; von Hippel P H; Yamamoto K R
Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health.
Science (New York, N.Y.) 1999;285(5428):666-7.
1999: Gregory T; Yu C; Ma A; Orkin S H; Blobel G A; Weiss M J
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
Blood 1999;94(1):87-96.
1999: Nardelli J; Thiesson D; Fujiwara Y; Tsai F Y; Orkin S H
Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system.
Developmental biology 1999;210(2):305-21.
1999: Vyas P; McDevitt M A; Cantor A B; Katz S G; Fujiwara Y; Orkin S H
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
Development (Cambridge, England) 1999;126(12):2799-811.
1999: Vyas P; Ault K; Jackson C W; Orkin S H; Shivdasani R A
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
Blood 1999;93(9):2867-75.
1999: Mao X; Fujiwara Y; Orkin S H
Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5037-42.
1999: Orkin S H; Porcher C; Fujiwara Y; Visvader J; Wang L C
Intersections between blood cell development and leukemia genes.
Cancer research 1999;59(7 Suppl):1784s-1787s; discussion 1788s.
1999: Crispino J D; Lodish M B; MacKay J P; Orkin S H
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.
Molecular cell 1999;3(2):219-28.
1999: Tevosian S G; Deconinck A E; Cantor A B; Rieff H I; Fujiwara Y; Corfas G; Orkin S H
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):950-5.
1999: Strauss E C; Orkin S H
Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting.
Methods in enzymology 1999;304():572-84.
1998: Gao Y; Sun Y; Frank K M; Dikkes P; Fujiwara Y; Seidl K J; Sekiguchi J M; Rathbun G A; Swat W; Wang J; Bronson R T; Malynn B A; Bryans M; Zhu C; Chaudhuri J; Davidson L; Ferrini R; Stamato T; Orkin S H; Greenberg M E; Alt F W
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Cell 1998;95(7):891-902.
1998: Zhou Y; Lim K C; Onodera K; Takahashi S; Ohta J; Minegishi N; Tsai F Y; Orkin S H; Yamamoto M; Engel J D
Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development.
The EMBO journal 1998;17(22):6689-700.
1998: Wang L C; Swat W; Fujiwara Y; Davidson L; Visvader J; Kuo F; Alt F W; Gilliland D G; Golub T R; Orkin S H
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.
Genes & development 1998;12(15):2392-402.
1998: Tsai F Y; Browne C P; Orkin S H
Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells.
Developmental biology 1998;196(2):218-27.
1998: Tsang A P; Fujiwara Y; Hom D B; Orkin S H
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.
Genes & development 1998;12(8):1176-88.
1998: Guy L G; Mei Q; Perkins A C; Orkin S H; Wall L
Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.
Blood 1998;91(7):2259-63.
1998: Blobel G A; Nakajima T; Eckner R; Montminy M; Orkin S H
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2061-6.
1998: Visvader J E; Fujiwara Y; Orkin S H
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.
Genes & development 1998;12(4):473-9.
1998: Orkin S H; Shivdasani R A; Fujiwara Y; McDevitt M A
Transcription factor GATA-1 in megakaryocyte development.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():79-83.
1998: Orkin S H
Embryonic stem cells and transgenic mice in the study of hematopoiesis.
The International journal of developmental biology 1998;42(7):927-34.
1997: Visvader J E; Mao X; Fujiwara Y; Hahm K; Orkin S H
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13707-12.
1997: Deveaux S; Cohen-Kaminsky S; Shivdasani R A; Andrews N C; Filipe A; Kuzniak I; Orkin S H; Roméo P H; Mignotte V
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.
The EMBO journal 1997;16(18):5654-61.
1997: Shivdasani R A; Fielder P; Keller G A; Orkin S H; de Sauvage F J
Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice.
Blood 1997;90(5):1821-7.
1997: Qu C K; Shi Z Q; Shen R; Tsai F Y; Orkin S H; Feng G S
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.
Molecular and cellular biology 1997;17(9):5499-507.
1997: Wang L C; Kuo F; Fujiwara Y; Gilliland D G; Golub T R; Orkin S H
Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.
The EMBO journal 1997;16(14):4374-83.
1997: Shivdasani R A; Fujiwara Y; McDevitt M A; Orkin S H
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.
The EMBO journal 1997;16(13):3965-73.
1997: Tsang A P; Visvader J E; Turner C A; Fujiwara Y; Yu C; Weiss M J; Crossley M; Orkin S H
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
Cell 1997;90(1):109-19.
1997: McDevitt M A; Fujiwara Y; Shivdasani R A; Orkin S H
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7976-81.
1997: McDevitt M A; Shivdasani R A; Fujiwara Y; Yang H; Orkin S H
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6781-5.
1997: Tsai F Y; Orkin S H
Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation.
Blood 1997;89(10):3636-43.
1997: Lien L L; Lee Y; Orkin S H
Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements.
Molecular and cellular biology 1997;17(4):2279-90.
1997: Weiss M J; Yu C; Orkin S H
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.
Molecular and cellular biology 1997;17(3):1642-51.
1997: Ma G T; Roth M E; Groskopf J C; Tsai F Y; Orkin S H; Grosveld F; Engel J D; Linzer D I
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
Development (Cambridge, England) 1997;124(4):907-14.
1997: Strauss E C; Orkin S H
Guanine-adenine ligation-mediated PCR in vivo footprinting.
Methods (San Diego, Calif.) 1997;11(2):164-70.
1997: Orkin S H; Zon L I
Genetics of erythropoiesis: induced mutations in mice and zebrafish.
Annual review of genetics 1997;31():33-60.
1996: Orkin S H
Development of the hematopoietic system.
Current opinion in genetics & development 1996;6(5):597-602.
1996: Fujiwara Y; Browne C P; Cunniff K; Goff S C; Orkin S H
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12355-8.
1996: Perkins A C; Gaensler K M; Orkin S H
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12267-71.
1996: Peters L L; Shivdasani R A; Liu S C; Hanspal M; John K M; Gonzalez J M; Brugnara C; Gwynn B; Mohandas N; Alper S L; Orkin S H; Lux S E
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton.
Cell 1996;86(6):917-27.
1996: Kieran M W; Perkins A C; Orkin S H; Zon L I
Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9126-31.
1996: Porcher C; Swat W; Rockwell K; Fujiwara Y; Alt F W; Orkin S H
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.
Cell 1996;86(1):47-57.
1996: Field S J; Tsai F Y; Kuo F; Zubiaga A M; Kaelin W G; Livingston D M; Orkin S H; Greenberg M E
E2F-1 functions in mice to promote apoptosis and suppress proliferation.
Cell 1996;85(4):549-61.
1996: Shivdasani R A; Orkin S H
The transcriptional control of hematopoiesis.
Blood 1996;87(10):4025-39.
1996: Crossley M; Whitelaw E; Perkins A; Williams G; Fujiwara Y; Orkin S H
Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells.
Molecular and cellular biology 1996;16(4):1695-705.
1996: Blobel G A; Orkin S H
Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1.
Molecular and cellular biology 1996;16(4):1687-94.
1996: Kotkow K J; Orkin S H
Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3514-8.
1996: Weiss M J; Orkin S H
In vitro differentiation of murine embryonic stem cells. New approaches to old problems.
The Journal of clinical investigation 1996;97(3):591-5.
1995: Orkin S H
Hematopoiesis: how does it happen?
Current opinion in cell biology 1995;7(6):870-7.
1995: Lewis B A; Orkin S H
A functional initiator element in the human beta-globin promoter.
The Journal of biological chemistry 1995;270(47):28139-44.
1995: Weiss M J; Orkin S H
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9623-7.
1995: Shivdasani R A; Orkin S H
Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8690-4.
1995: Kotkow K J; Orkin S H
Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer.
Molecular and cellular biology 1995;15(8):4640-7.
1995: Orkin S H
Regulation of globin gene expression in erythroid cells.
European journal of biochemistry / FEBS 1995;231(2):271-81.
1995: Shivdasani R A; Rosenblatt M F; Zucker-Franklin D; Jackson C W; Hunt P; Saris C J; Orkin S H
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Cell 1995;81(5):695-704.
1995: Blobel G A; Sieff C A; Orkin S H
Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
Molecular and cellular biology 1995;15(6):3147-53.
1995: Perkins A C; Sharpe A H; Orkin S H
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.
Nature 1995;375(6529):318-22.
1995: Crossley M; Merika M; Orkin S H
Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains.
Molecular and cellular biology 1995;15(5):2448-56.
1995: Merika M; Orkin S H
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF.
Molecular and cellular biology 1995;15(5):2437-47.
1995: Skoda R C; Tsai S F; Orkin S H; Leder P
Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice.
The Journal of experimental medicine 1995;181(5):1603-13.
1995: Chui D H; Tang W; Orkin S H
cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor.
Biochemical and biophysical research communications 1995;209(1):40-6.
1995: Orkin S H
Transcription factors and hematopoietic development.
The Journal of biological chemistry 1995;270(10):4955-8.
1995: Zhang R; Alt F W; Davidson L; Orkin S H; Swat W
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene.
Nature 1995;374(6521):470-3.
1995: Shivdasani R A; Mayer E L; Orkin S H
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
Nature 1995;373(6513):432-4.
1995: Weiss M J; Orkin S H
GATA transcription factors: key regulators of hematopoiesis.
Experimental hematology 1995;23(2):99-107.
1995: Visvader J E; Crossley M; Hill J; Orkin S H; Adams J M
The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.
Molecular and cellular biology 1995;15(2):634-41.
1995: Blobel G A; Simon M C; Orkin S H
Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins.
Molecular and cellular biology 1995;15(2):626-33.
1995: Pollock J D; Williams D A; Gifford M A; Li L L; Du X; Fisherman J; Orkin S H; Doerschuk C M; Dinauer M C
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.
Nature genetics 1995;9(2):202-9.
1995: Ney P A; Farina S F; Bodine D M; Andrews N C; Orkin S H; Neinhuis A W
Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2.
Experimental hematology 1995;23(1):74-80.
1995: Pevny L; Lin C S; D'Agati V; Simon M C; Orkin S H; Costantini F
Development of hematopoietic cells lacking transcription factor GATA-1.
Development (Cambridge, England) 1995;121(1):163-72.
1994: Zhang R; Tsai F Y; Orkin S H
Hematopoietic development of vav-/- mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12755-9.
1994: Tsai F Y; Keller G; Kuo F C; Weiss M; Chen J; Rosenblatt M; Alt F W; Orkin S H
An early haematopoietic defect in mice lacking the transcription factor GATA-2.
Nature 1994;371(6494):221-6.
1994: Aufiero B; Neufeld E J; Orkin S H
Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7757-61.
1994: Crossley M; Orkin S H
Phosphorylation of the erythroid transcription factor GATA-1.
The Journal of biological chemistry 1994;269(24):16589-96.
1994: Crossley M; Tsang A P; Bieker J J; Orkin S H
Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.
The Journal of biological chemistry 1994;269(22):15440-4.
1994: Weiss M J; Keller G; Orkin S H
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.
Genes & development 1994;8(10):1184-97.
1994: Andrews N C; Orkin S H
Transcriptional control of erythropoiesis.
Current opinion in hematology 1994;1(2):119-24.
1994: Gessler M; König A; Arden K; Grundy P; Orkin S; Sallan S; Peters C; Ruyle S; Mandell J; Li F
Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.
Human mutation 1994;3(3):212-22.
1993: Andrews N C; Kotkow K J; Ney P A; Erdjument-Bromage H; Tempst P; Orkin S H
The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11488-92.
1993: Zhen L; King A A; Xiao Y; Chanock S J; Orkin S H; Dinauer M C
Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9832-6.
1993: Bodine D M; Moritz T; Donahue R E; Luskey B D; Kessler S W; Martin D I; Orkin S H; Nienhuis A W; Williams D A
Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells.
Blood 1993;82(7):1975-80.
1993: Ney P A; Andrews N C; Jane S M; Safer B; Purucker M E; Weremowicz S; Morton C C; Goff S C; Orkin S H; Nienhuis A W
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.
Molecular and cellular biology 1993;13(9):5604-12.
1993: Kreider B L; Orkin S H; Ihle J N
Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6454-8.
1993: Merika M; Orkin S H
DNA-binding specificity of GATA family transcription factors.
Molecular and cellular biology 1993;13(7):3999-4010.
1993: Zon L I; Yamaguchi Y; Yee K; Albee E A; Kimura A; Bennett J C; Orkin S H; Ackerman S J
Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
Blood 1993;81(12):3234-41.
1993: Crossley M; Orkin S H
Regulation of the beta-globin locus.
Current opinion in genetics & development 1993;3(2):232-7.
1993: Peters L L; Andrews N C; Eicher E M; Davidson M B; Orkin S H; Lux S E
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.
Nature 1993;362(6422):768-70.
1993: Andrews N C; Erdjument-Bromage H; Davidson M B; Tempst P; Orkin S H
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.
Nature 1993;362(6422):722-8.
1993: Arceci R J; King A A; Simon M C; Orkin S H; Wilson D B
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
Molecular and cellular biology 1993;13(4):2235-46.
1993: Scherer S W; Neufeld E J; Lievens P M; Orkin S H; Kim J; Tsui L C
Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids.
Genomics 1993;15(3):695-6.
1992: Aplan P D; Nakahara K; Orkin S H; Kirsch I R
The SCL gene product: a positive regulator of erythroid differentiation.
The EMBO journal 1992;11(11):4073-81.
1992: de Boer M; Bolscher B G; Dinauer M C; Orkin S H; Smith C I; Ahlin A; Weening R S; Roos D
Splice site mutations are a common cause of X-linked chronic granulomatous disease.
Blood 1992;80(6):1553-8.
1992: Orkin S H
GATA-binding transcription factors in hematopoietic cells.
Blood 1992;80(3):575-81.
1992: Sposi N M; Zon L I; Carè A; Valtieri M; Testa U; Gabbianelli M; Mariani G; Bottero L; Mather C; Orkin S H
Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6353-7.
1992: Strauss E C; Orkin S H
In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5809-13.
1992: Strauss E C; Andrews N C; Higgs D R; Orkin S H
In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.
Molecular and cellular biology 1992;12(5):2135-42.
1992: Simon M C; Pevny L; Wiles M V; Keller G; Costantini F; Orkin S H
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells.
Nature genetics 1992;1(2):92-8.
1992: Zon L I; Orkin S H
Sequence of the human GATA-1 promoter.
Nucleic acids research 1992;20(7):1812.
1992: Neufeld E J; Skalnik D G; Lievens P M; Orkin S H
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
Nature genetics 1992;1(1):50-5.
1992: Dorfman D M; Wilson D B; Bruns G A; Orkin S H
Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.
The Journal of biological chemistry 1992;267(2):1279-85.
1992: Dinauer M C; Orkin S H
Chronic granulomatous disease.
Annual review of medicine 1992;43():117-24.
1991: Zon L I; Mather C; Burgess S; Bolce M E; Harland R M; Orkin S H
Expression of GATA-binding proteins during embryonic development in Xenopus laevis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10642-6.
1991: Dinauer M C; Pierce E A; Erickson R W; Muhlebach T J; Messner H; Orkin S H; Seger R A; Curnutte J T
Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11231-5.
1991: Zon L I; Gurish M F; Stevens R L; Mather C; Reynolds D S; Austen K F; Orkin S H
GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene.
The Journal of biological chemistry 1991;266(34):22948-53.
1991: Zon L I; Youssoufian H; Mather C; Lodish H F; Orkin S H
Activation of the erythropoietin receptor promoter by transcription factor GATA-1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10638-41.
1991: Skalnik D G; Dorfman D M; Perkins A S; Jenkins N A; Copeland N G; Orkin S H
Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8505-9.
1991: Skalnik D G; Strauss E C; Orkin S H
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
The Journal of biological chemistry 1991;266(25):16736-44.
1991: Skalnik D G; Dorfman D M; Williams D A; Orkin S H
Restriction of neuroblastoma to the prostate gland in transgenic mice.
Molecular and cellular biology 1991;11(9):4518-27.
1991: Marsden P A; Dorfman D M; Collins T; Brenner B M; Orkin S H; Ballermann B J
Regulated expression of endothelin 1 in glomerular capillary endothelial cells.
The American journal of physiology 1991;261(1 Pt 2):F117-25.
1991: Tsai S F; Strauss E; Orkin S H
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.
Genes & development 1991;5(6):919-31.
1991: Ho I C; Vorhees P; Marin N; Oakley B K; Tsai S F; Orkin S H; Leiden J M
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.
The EMBO journal 1991;10(5):1187-92.
1991: Chapman V M; Stephenson D A; Mullins L J; Keitz B T; Disteche C; Orkin S H
Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice.
Genomics 1991;9(2):309-13.
1991: Pevny L; Simon M C; Robertson E; Klein W H; Tsai S F; D'Agati V; Orkin S H; Costantini F
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.
Nature 1991;349(6306):257-60.
1990: Orkin S H
Preparing for the next generation.
The Journal of clinical investigation 1990;86(6):1773-6.
1990: Ezekowitz R A; Sieff C A; Dinauer M C; Nathan D G; Orkin S H; Newburger P E
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell.
Blood 1990;76(12):2443-8.
1990: Orkin S H
Cell-specific transcription and cell differentiation in the erythroid lineage.
Current opinion in cell biology 1990;2(6):1003-12.
1990: Whitelaw E; Tsai S F; Hogben P; Orkin S H
Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse.
Molecular and cellular biology 1990;10(12):6596-606.
1990: Martin D I; Orkin S H
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.
Genes & development 1990;4(11):1886-98.
1990: Dinauer M C; Pierce E A; Bruns G A; Curnutte J T; Orkin S H
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
The Journal of clinical investigation 1990;86(5):1729-37.
1990: Young R M; Mendoza A E; Collins T; Orkin S H
Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins.
Molecular and cellular biology 1990;10(11):6051-4.
1990: Orkin S H
Globin gene regulation and switching: circa 1990.
Cell 1990;63(4):665-72.
1990: Yamamoto M; Ko L J; Leonard M W; Beug H; Orkin S H; Engel J D
Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
Genes & development 1990;4(10):1650-62.
1990: Wilson D B; Dorfman D M; Orkin S H
A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.
Molecular and cellular biology 1990;10(9):4854-62.
1990: Youssoufian H; Zon L I; Orkin S H; D'Andrea A D; Lodish H F
Structure and transcription of the mouse erythropoietin receptor gene.
Molecular and cellular biology 1990;10(7):3675-82.
1990: Martin D I; Zon L I; Mutter G; Orkin S H
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages.
Nature 1990;344(6265):444-7.
1990: Mendoza A E; Young R; Orkin S H; Collins T
Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2177-81.
1990: Gessler M; Poustka A; Cavenee W; Neve R L; Orkin S H; Bruns G A
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping.
Nature 1990;343(6260):774-8.
1990: Skalnik D G; Orkin S
A rapid method for characterizing transgenic mice.
BioTechniques 1990;8(1):34.
1990: Zon L I; Tsai S F; Burgess S; Matsudaira P; Bruns G A; Orkin S H
The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):668-72.
1990: Luskey B D; Lim B; Apperley J F; Orkin S H; Williams D A
Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells.
Annals of the New York Academy of Sciences 1990;612():398-406.
1990: Skalnik D G; Dorfman D M; Perkins A S; Jenkins N A; Copeland N G; Orkin S H
Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies.
Transactions of the Association of American Physicians 1990;103():129-36.
1989: Dinauer M C; Curnutte J T; Rosen H; Orkin S H
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.
The Journal of clinical investigation 1989;84(6):2012-6.
1989: Lim B; Apperley J F; Orkin S H; Williams D A
Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8892-6.
1989: Quinn M T; Parkos C A; Walker L; Orkin S H; Dinauer M C; Jesaitis A J
Association of a Ras-related protein with cytochrome b of human neutrophils.
Nature 1989;342(6246):198-200.
1989: Wise R J; Orkin S H; Collins T
Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells.
Nucleic acids research 1989;17(16):6591-601.
1989: Zon L I; Dorfman D M; Orkin S H
The polymerase chain reaction colony miniprep.
BioTechniques 1989;7(7):696-8.
1989: Tsai S F; Martin D I; Zon L I; D'Andrea A D; Wong G G; Orkin S H
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.
Nature 1989;339(6224):446-51.
1989: Dorfman D M; Zon L I; Orkin S H
Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR).
BioTechniques 1989;7(6):568, 570.
1989: Parkos C A; Dinauer M C; Jesaitis A J; Orkin S H; Curnutte J T
Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease.
Blood 1989;73(6):1416-20.
1989: Wong C; Antonarakis S E; Goff S C; Orkin S H; Forget B G; Nathan D G; Giardina P J; Kazazian H H
Beta-thalassemia due to two novel nucleotide substitutions in consensus acceptor splice sequences of the beta-globin gene.
Blood 1989;73(4):914-8.
1989: Martin D I; Tsai S F; Orkin S H
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor.
Nature 1989;338(6214):435-8.
1989: Hirschhorn R; Tzall S; Ellenbogen A; Orkin S H
Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency.
The Journal of clinical investigation 1989;83(2):497-501.
1989: Orkin S H
X-linked chronic granulomatous disease: more than two years later.
Molecular biology & medicine 1989;6(1):1-5.
1989: Orkin S H
Molecular genetics of chronic granulomatous disease.
Annual review of immunology 1989;7():277-307.
1989: Martin D I; Orkin S H
An erythroid-specific DNA binding factor mediates increased gamma-globin expression in hereditary persistence of fetal hemoglobin (HPFH).
Progress in clinical and biological research 1989;316A():217-28.
1989: Miller B A; Salameh M; Ahmed M; Olivieri N; Huisman T H; Orkin S H; Nathan D G
Saudi Arabian sickle cell anemia. A molecular approach.
Annals of the New York Academy of Sciences 1989;565():143-51.
1988: de Saint-Basile G; Bohler M C; Fischer A; Cartron J; Dufier J L; Griscelli C; Orkin S H
Xp21 DNA microdeletion in a patient with chronic granulomatous disease, retinitis pigmentosa, and McLeod phenotype.
Human genetics 1988;80(1):85-9.
1988: Barker K A; Orkin S H; Newburger P E
Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60.
Molecular and cellular biology 1988;8(7):2804-10.
1988: Newburger P E; Ezekowitz R A; Whitney C; Wright J; Orkin S H
Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5215-9.
1988: Ezekowitz R A; Dinauer M C; Jaffe H S; Orkin S H; Newburger P E
Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma.
The New England journal of medicine 1988;319(3):146-51.
1988: Dinauer M C; Orkin S H
Chronic granulomatous disease. Molecular genetics.
Hematology/oncology clinics of North America 1988;2(2):225-40.
1988: Parkos C A; Dinauer M C; Walker L E; Allen R A; Jesaitis A J; Orkin S H
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3319-23.
1988: Bonthron D T; Morton C C; Orkin S H; Collins T
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1492-6.
1988: Frey D; Mächler M; Seger R; Schmid W; Orkin S H
Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus.
Blood 1988;71(1):252-5.
1988: Wise R J; Pittman D D; Handin R I; Kaufman R J; Orkin S H
The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers.
Cell 1988;52(2):229-36.
1988: Bonthron D; Orkin S H
The human von Willebrand factor gene. Structure of the 5' region.
European journal of biochemistry / FEBS 1988;171(1-2):51-7.
1988: Orkin S H; Williams D A
Gene therapy of somatic cells: status and prospects.
Progress in medical genetics 1988;7():130-42.
1988: Brockdorff N; Fisher E M; Orkin S H; Lyon M F; Brown S D
Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.
Cytogenetics and cell genetics 1988;48(2):124-5.
1988: Dinauer M C; Orkin S H
Molecular genetics of chronic granulomatous disease.
Immunodeficiency reviews 1988;1(1):55-69.
1987: Wojchowski D M; Orkin S H; Sytkowski A J
Active human erythropoietin expressed in insect cells using a baculovirus vector: a role for N-linked oligosaccharide.
Biochimica et biophysica acta 1987;910(3):224-32.
1987: Lim B; Williams D A; Orkin S H
Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo.
Molecular and cellular biology 1987;7(10):3459-65.
1987: Orkin S H
Genetic diagnosis by DNA analysis: progress through amplification.
The New England journal of medicine 1987;317(16):1023-5.
1987: Ezekowitz R A; Orkin S H; Newburger P E
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.
The Journal of clinical investigation 1987;80(4):1009-16.
1987: Olivieri N F; Chang L S; Poon A O; Michelson A M; Orkin S H
An alpha-globin gene initiation codon mutation in a black family with HbH disease.
Blood 1987;70(3):729-32.
1987: Vogelstein B; Fearon E R; Hamilton S R; Preisinger A C; Willard H F; Michelson A M; Riggs A D; Orkin S H
Clonal analysis using recombinant DNA probes from the X-chromosome.
Cancer research 1987;47(18):4806-13.
1987: Miller B A; Salameh M; Ahmed M; Olivieri N; Antognetti G; Orkin S H; Huisman T H; Nathan D G
Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia.
Blood 1987;70(3):716-20.
1987: Collins T; Bonthron D T; Orkin S H
Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain.
Nature 1987;328(6131):621-4.
1987: Dinauer M C; Orkin S H; Brown R; Jesaitis A J; Parkos C A
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex.
Nature 1987;327(6124):717-20.
1987: Miller B A; Olivieri N; Salameh M; Ahmed M; Antognetti G; Huisman T H; Nathan D G; Orkin S H
Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia.
The New England journal of medicine 1987;316(5):244-50.
1987: Williams D A; Lim B; Orkin S H
Transfer and expression of human ADA in murine hematopoietic stem cells.
Progress in clinical and biological research 1987;251():567-80.
1987: Orkin S H
"Forward" and "reverse" genetics of inherited human disorders: the thalassemia syndromes and chronic granulomatous disease.
Harvey lectures 1987;83():57-76.
1987: Miller B A; Salameh M; Ahmed M; Olivieri N; Huisman T H; Orkin S H; Nathan D G
Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia.
Progress in clinical and biological research 1987;251():415-26.
1986: Orkin S H
Reverse genetics and human disease.
Cell 1986;47(6):845-50.
1986: Bonthron D T; Handin R I; Kaufman R J; Wasley L C; Orr E C; Mitsock L M; Ewenstein B; Loscalzo J; Ginsburg D; Orkin S H
Structure of pre-pro-von Willebrand factor and its expression in heterologous cells.
Nature 1986;324(6094):270-3.
1986: Kwiatkowski D J; Stossel T P; Orkin S H; Mole J E; Colten H R; Yin H L
Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain.
Nature 1986;323(6087):455-8.
1986: Bonthron D; Orr E C; Mitsock L M; Ginsburg D; Handin R I; Orkin S H
Nucleotide sequence of pre-pro-von Willebrand factor cDNA.
Nucleic acids research 1986;14(17):7125-7.
1986: Wong C; Antonarakis S E; Goff S C; Orkin S H; Boehm C D; Kazazian H H
On the origin and spread of beta-thalassemia: recurrent observation of four mutations in different ethnic groups.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6529-32.
1986: Orkin S H
Molecular genetics and potential gene therapy.
Clinical immunology and immunopathology 1986;40(1):151-6.
1986: Royer-Pokora B; Kunkel L M; Monaco A P; Goff S C; Newburger P E; Baehner R L; Cole F S; Curnutte J T; Orkin S H
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.
Nature 1986;322(6074):32-8.
1986: Kazazian H H; Orkin S H; Boehm C D; Goff S C; Wong C; Dowling C E; Newburger P E; Knowlton R G; Brown V; Donis-Keller H
Characterization of a spontaneous mutation to a beta-thalassemia allele.
American journal of human genetics 1986;38(6):860-7.
1986: Fay P J; Kawai Y; Wagner D D; Ginsburg D; Bonthron D; Ohlsson-Wilhelm B M; Chavin S I; Abraham G N; Handin R I; Orkin S H
Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II.
Science (New York, N.Y.) 1986;232(4753):995-8.
1986: Baehner R L; Kunkel L M; Monaco A P; Haines J L; Conneally P M; Palmer C; Heerema N; Orkin S H
DNA linkage analysis of X chromosome-linked chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3398-401.
1986: van den Elsen P; Georgopoulos K; Shepley B A; Orkin S; Terhorst C
Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2944-8.
1986: Miller B A; Salameh M; Ahmed M; Wainscoat J; Antognetti G; Orkin S; Weatherall D; Nathan D G
High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined.
Blood 1986;67(5):1404-10.
1986: Williams D A; Orkin S H
Somatic gene therapy. Current status and future prospects.
The Journal of clinical investigation 1986;77(4):1053-6.
1986: Williams D A; Orkin S H; Mulligan R C
Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2566-70.
1986: Groopman J E; Sullivan J L; Mulder C; Ginsburg D; Orkin S H; O'Hara C J; Falchuk K; Wong-Staal F; Gallo R C
Pathogenesis of B cell lymphoma in a patient with AIDS.
Blood 1986;67(3):612-5.
1986: Horányi M; Földi J; Szelényi J G; Hollán S R; István L; Orkin S H
First occurrence of Hb H in Hungary.
Haematologia 1986;19(3):193-5.
1986: Daddona P E; Orkin S H; Kelley W N
Expression defects of mutant human adenosine deaminase.
Advances in experimental medicine and biology 1986;195 Pt A():217-22.
1986: Ma N S; Gerhard D S; Housman D E; Orkin S; Bruns G
Owl monkey gene mapping: the assignment of gene loci for catalase, beta-globin gene cluster, HRAS1, insulin, and parathyroid hormone.
Cytogenetics and cell genetics 1986;43(1-2):57-68.
1986: Royer-Pokora B; Kunkel L M; Monaco A P; Goff S C; Newburger P E; Baehner R L; Cole F S; Curnutte J T; Orkin S H
Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():177-83.
1985: Antin J H; Ginsburg D; Smith B R; Nathan D G; Orkin S H; Rappeport J M
Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria: eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment.
Blood 1985;66(6):1247-50.
1985: Erickson R P; Michelson A M; Rosenberg M P; Sánchez E; Orkin S H
Post-meiotic transcription of phosphoglycerate-kinase 2 in mouse testes.
Bioscience reports 1985;5(12):1087-91.
1985: Michelson A M; Blake C C; Evans S T; Orkin S H
Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(20):6965-9.
1985: Collins T; Ginsburg D; Boss J M; Orkin S H; Pober J S
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis.
Nature 1985;316(6030):748-50.
1985: Bonthron D T; Markham A F; Ginsburg D; Orkin S H
Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency.
The Journal of clinical investigation 1985;76(2):894-7.
1985: Prochownik E V; Bock S C; Orkin S H
Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily.
The Journal of biological chemistry 1985;260(17):9608-12.
1985: Ginsburg D; Handin R I; Bonthron D T; Donlon T A; Bruns G A; Latt S A; Orkin S H
Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization.
Science (New York, N.Y.) 1985;228(4706):1401-6.
1985: Ault K A; Antin J H; Ginsburg D; Orkin S H; Rappeport J M; Keohan M L; Martin P; Smith B R
Phenotype of recovering lymphoid cell populations after marrow transplantation.
The Journal of experimental medicine 1985;161(6):1483-502.
1985: Michelson A M; Bruns G A; Morton C C; Orkin S H
The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked locus containing a processed pseudogene and its functional counterpart.
The Journal of biological chemistry 1985;260(11):6982-92.
1985: van den Elsen P; Bruns G; Gerhard D S; Pravtcheva D; Jones C; Housman D; Ruddle F A; Orkin S; Terhorst C
Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(9):2920-4.
1985: Orkin S H; Goff S C; Kelley W N; Daddona P E
Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution.
Molecular and cellular biology 1985;5(4):762-7.
1985: Orkin S H; Cheng T C; Antonarakis S E; Kazazian H H
Thalassemia due to a mutation in the cleavage-polyadenylation signal of the human beta-globin gene.
The EMBO journal 1985;4(2):453-6.
1985: Ginsburg D; Antin J H; Smith B R; Orkin S H; Rappeport J M
Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms.
The Journal of clinical investigation 1985;75(2):596-603.
1985: Antonarakis S E; Kazazian H H; Orkin S H
DNA polymorphism and molecular pathology of the human globin gene clusters.
Human genetics 1985;69(1):1-14.
1985: Daddona P E; Orkin S H; Shewach D S; Kelley W N
cDNA and amino acid sequence of human adenosine deaminase.
Annals of the New York Academy of Sciences 1985;451():238-44.
1984: Huebner K; Nagarajan L; deJesus E; Orkin S H; Caskey C T; Croce C M
Activity of X-linked genes in stem and differentiated Mus musculus X Mus caroli hybrid cells.
Cell differentiation 1984;15(2-4):241-8.
1984: Prochownik E V; Orkin S H
In vivo transcription of a human antithrombin III "minigene".
The Journal of biological chemistry 1984;259(24):15386-92.
1984: van den Elsen P; Shepley B A; Borst J; Coligan J E; Markham A F; Orkin S; Terhorst C
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.
Nature 1984;312(5993):413-8.
1984: Daddona P E; Shewach D S; Kelley W N; Argos P; Markham A F; Orkin S H
Human adenosine deaminase. cDNA and complete primary amino acid sequence.
The Journal of biological chemistry 1984;259(19):12101-6.
1984: Orkin S H
Molecular analysis of human disease: dissection of beta-thalassemia.
Clinical research 1984;32(3):329-33.
1984: Platt O S; Orkin S H; Dover G; Beardsley G P; Miller B; Nathan D G
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.
The Journal of clinical investigation 1984;74(2):652-6.
1984: Kazazian H H; Orkin S H; Markham A F; Chapman C R; Youssoufian H; Waber P G
Quantification of the close association between DNA haplotypes and specific beta-thalassaemia mutations in Mediterraneans.
Nature 1984;310(5973):152-4.
1984: Orkin S H; Antonarakis S E; Loukopoulos D
Abnormal processing of beta Knossos RNA.
Blood 1984;64(1):311-3.
1984: Orkin S H; Antonarakis S E; Kazazian H H
Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC.
The Journal of biological chemistry 1984;259(14):8679-81.
1984: Weinberg R S; Antonarakis S E; Kazazian H H; Dover G J; Orkin S H; Lenes A L; Schofield J M; Alter B P
Fetal hemoglobin synthesis in erythroid cultures in hereditary persistence of fetal hemoglobin and beta o-thalassemia.
Blood 1984;63(6):1278-84.
1984: Morton C C; Kirsch I R; Taub R; Orkin S H; Brown J A
Localization of the beta-globin gene by chromosomal in situ hybridization.
American journal of human genetics 1984;36(3):576-85.
1984: Cheng T C; Orkin S H; Antonarakis S E; Potter M J; Sexton J P; Markham A F; Giardina P J; Li A; Kazazian H H
beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(9):2821-5.
1984: Orkin S H; Goldman D S; Sallan S E
Development of homozygosity for chromosome 11p markers in Wilms' tumour.
Nature 1984;309(5964):172-4.
1984: Kazazian H H; Orkin S H; Antonarakis S E; Sexton J P; Boehm C D; Goff S C; Waber P G
Molecular characterization of seven beta-thalassemia mutations in Asian Indians.
The EMBO journal 1984;3(3):593-6.
1984: Orkin S H
Prenatal diagnosis of hemoglobin disorders by DNA analysis.
Blood 1984;63(2):249-53.
1984: Hutz M H; Michelson A M; Antonarakis S E; Orkin S H; Kazazian H H
Restriction site polymorphism in the phosphoglycerate kinase gene on the X chromosome.
Human genetics 1984;66(2-3):217-9.
1984: Platt O S; Orkin S H; Dover G; Beardsley G P; Miller B; Nathan D G
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia.
Transactions of the Association of American Physicians 1984;97():268-74.
1984: Orkin S H; Kazazian H H
The mutation and polymorphism of the human beta-globin gene and its surrounding DNA.
Annual review of genetics 1984;18():131-71.
1983: Michelson A M; Orkin S H
Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination.
The Journal of biological chemistry 1983;258(24):15245-54.
1983: Orkin S H; Daddona P E; Shewach D S; Markham A F; Bruns G A; Goff S C; Kelley W N
Molecular cloning of human adenosine deaminase gene sequences.
The Journal of biological chemistry 1983;258(21):12753-6.
1983: Kazazian H H; Orkin S H; Boehm C D; Sexton J P; Antonarakis S E
beta-Thalassemia due to a deletion of the nucleotide which is substituted in the beta S-globin gene.
American journal of human genetics 1983;35(5):1028-33.
1983: Orkin S H; Sexton J P; Cheng T C; Goff S C; Giardina P J; Lee J I; Kazazian H H
ATA box transcription mutation in beta-thalassemia.
Nucleic acids research 1983;11(14):4727-34.
1983: Prochownik E V; Markham A F; Orkin S H
Isolation of a cDNA clone for human antithrombin III.
The Journal of biological chemistry 1983;258(13):8389-94.
1983: Schwaber J; Molgaard H; Orkin S H; Gould H J; Rosen F S
Early pre-B cells from normal and X-linked agammaglobulinaemia produce C mu without an attached VH region.
Nature 1983;304(5924):355-8.
1983: Fearon E R; Kazazian H H; Waber P G; Lee J I; Antonarakis S E; Orkin S H; Vanin E F; Henthorn P S; Grosveld F G; Scott A F; Buchanan G R
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia.
Blood 1983;61(6):1269-74.
1983: Prochownik E V; Antonarakis S; Bauer K A; Rosenberg R D; Fearon E R; Orkin S H
Molecular heterogeneity of inherited antithrombin III deficiency.
The New England journal of medicine 1983;308(26):1549-52.
1983: Orkin S H; Sexton J P; Goff S C; Kazazian H H
Inactivation of an acceptor RNA splice site by a short deletion in beta-thalassemia.
The Journal of biological chemistry 1983;258(12):7249-51.
1983: Wainscoat J S; Old J M; Weatherall D J; Orkin S H
The molecular basis for the clinical diversity of beta thalassaemia in Cypriots.
Lancet 1983;1(8336):1235-7.
1983: Treisman R; Orkin S H; Maniatis T
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes.
Nature 1983;302(5909):591-6.
1983: Orkin S H; Markham A F; Kazazian H H
Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis.
The Journal of clinical investigation 1983;71(3):775-9.
1983: Michelson A M; Markham A F; Orkin S H
Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(2):472-6.
1983: Orkin S H
Controlling the fetal globin switch in man.
Nature 1983;301(5896):108-9.
1983: Orkin S H; Antonarakis S E; Kazazian H H
Polymorphism and molecular pathology of the human beta-globin gene.
Progress in hematology 1983;13():49-73.
1983: Treisman R; Orkin S H; Maniatis T
Structural and functional defects in beta-thalassemia.
Progress in clinical and biological research 1983;134():99-121.
1983: Dryja T P; Bruns G A; Orkin S H; Albert D M; Gerald P S
Isolation of DNA fragments from chromosome 13.
Retina (Philadelphia, Pa.) 1983;3(2):121-5.
1982: Orkin S H; Kazazian H H; Antonarakis S E; Ostrer H; Goff S C; Sexton J P
Abnormal RNA processing due to the exon mutation of beta E-globin gene.
Nature 1982;300(5894):768-9.
1982: Spritz R A; Orkin S H
Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene.
Nucleic acids research 1982;10(24):8025-9.
1982: Michelson A M; Orkin S H
Characterization of the homopolymer tailing reaction catalyzed by terminal deoxynucleotidyl transferase. Implications for the cloning of cDNA.
The Journal of biological chemistry 1982;257(24):14773-82.
1982: Antonarakis S E; Orkin S H; Kazazian H H; Goff S C; Boehm C D; Waber P G; Sexton J P; Ostrer H; Fairbanks V F; Chakravarti A
Evidence for multiple origins of the beta E-globin gene in Southeast Asia.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(21):6608-11.
1982: Felber B K; Orkin S H; Hamer D H
Abnormal RNA splicing causes one form of alpha thalassemia.
Cell 1982;29(3):895-902.
1982: Orkin S H; Little P F; Kazazian H H; Boehm C D
Improved detection of the sickle mutation by DNA analysis: application to prenatal diagnosis.
The New England journal of medicine 1982;307(1):32-6.
1982: Orkin S H; Kazazian H H; Antonarakis S E; Goff S C; Boehm C D; Sexton J P; Waber P G; Giardina P J
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.
Nature 1982;296(5858):627-31.
1982: Orkin S H
Genetic diagnosis of the fetus.
Nature 1982;296(5854):202-3.
1982: Disteche C M; Kunkel L M; Lojewski A; Orkin S H; Eisenhard M; Sahar E; Travis B; Latt S A
Isolation of mouse x-chromosome specific DNA from an x-enriched lambda phage library derived from flow sorted chromosomes.
Cytometry 1982;2(5):282-6.
1982: Kurnit D; Orkin S; White R
Prenatal analysis of human DNA-sequence variation.
Methods in cell biology 1982;26():311-30.
1981: Orkin S H; Goff S C
Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes.
The Journal of biological chemistry 1981;256(19):9782-4.
1981: Orkin S H; Goff S C; Hechtman R L
Mutation in an intervening sequence splice junction in man.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(8):5041-5.
1981: Orkin S H; Goff S C
The duplicated human alpha-globin genes: their relative expression as measured by RNA analysis.
Cell 1981;24(2):345-51.
1981: Orkin S H; Goff S C; Nathan D G
Heterogeneity of DNA deletion in gamma delta beta-thalassemia.
The Journal of clinical investigation 1981;67(3):878-84.
1981: Orkin S H; Nathan D G
The molecular genetics of thalassemia.
Advances in human genetics 1981;11():233-80.
1980: Michelson A M; Orkin S H
The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent.
Cell 1980;22(2 Pt 2):371-7.
1980: Orkin S H; Michelson A
Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia.
Nature 1980;286(5772):538-40.
1980: Orkin S H; Kolodner R; Michelson A; Husson R
Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3558-62.
1980: Orkin S H
The alpha thalassemias.
Texas reports on biology and medicine 1980;40():335-42.
1980: Alter B P; Orkin S H; Forget B G; Nathan D G
Prenatal diagnosis of hemoglobinopathies: the New England approach.
Annals of the New York Academy of Sciences 1980;344():151-64.
1980: Orkin S H
Specific abnormalities of globin gene organization in the thalassemia syndromes.
Annals of the New York Academy of Sciences 1980;344():48-61.
1979: Nathan D G; Alter B P; Orkin S H
Prenatal diagnosis of hemoglobinopathies.
Clinics in perinatology 1979;6(2):275-91.
1979: Orkin S H; Old J; Lazarus H; Altay C; Gurgey A; Weatherall D J; Nathan D G
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease.
Cell 1979;17(1):33-42.
1979: Orkin S H; Old J M; Weatherall D J; Nathan D G
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(5):2400-4.
1978: Orkin S H; Alter B P; Altay C; Mahoney M J; Lazarus H; Hobbins J C; Nathan D G
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion.
The New England journal of medicine 1978;299(4):166-72.
1976: Orkin S H; Nathan D G
The thalassemias.
The New England journal of medicine 1976;295(13):710-4.
1976: Orkin S H; Nathan D G
The molecular genetics of thalassemia.
Birth defects original article series 1976;12(8):145-59.

Sign-in to see more