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Joseph Orly

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Eli Anuka; Michael Gal; Douglas M Stocco; Joseph Orly
Expression and roles of steroidogenic acute regulatory (StAR) protein in 'non-classical', extra-adrenal and extra-gonadal cells and tissues.
Natalie Yivgi-Ohana; Noa Sher; Naomi Melamed-Book; Sarah Eimerl; Moriah Koler; Pulak R Manna; Douglas M Stocco; Joseph Orly
Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation.
Fatum Muhammad; Natalie Yivgi-Ohana; David Shveiky; Joseph Orly; Simon Alexander; Neri Laufer
Levels of steroidogenic acute regulatory protein and mitochondrial membrane potential in granulosa cells of older poor-responder women.

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All Publications

2013: Eli Anuka; Michael Gal; Douglas M Stocco; Joseph Orly
Expression and roles of steroidogenic acute regulatory (StAR) protein in 'non-classical', extra-adrenal and extra-gonadal cells and tissues.
Molecular and cellular endocrinology 2013;371(1-2):47-61.
2009: Natalie Yivgi-Ohana; Noa Sher; Naomi Melamed-Book; Sarah Eimerl; Moriah Koler; Pulak R Manna; Douglas M Stocco; Joseph Orly
Transcription of steroidogenic acute regulatory protein in the rodent ovary and placenta: alternative modes of cyclic adenosine 3', 5'-monophosphate dependent and independent regulation.
Endocrinology 2009;150(2):977-89.
2009: Fatum Muhammad; Natalie Yivgi-Ohana; David Shveiky; Joseph Orly; Simon Alexander; Neri Laufer
Levels of steroidogenic acute regulatory protein and mitochondrial membrane potential in granulosa cells of older poor-responder women.
Fertility and sterility 2009;91(1):220-5.
2008: Goro Sasaki; Tomohiro Ishii; Pancharatnam Jeyasuria; Youngah Jo; Assaf Bahat; Joseph Orly; Tomonobu Hasegawa; Keith L Parker
Complex role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by bacterial artificial chromosome transgenesis in vivo.
Molecular endocrinology (Baltimore, Md.) 2008;22(4):951-64.
2007: Zvi Granot; Oren Kobiler; Naomi Melamed-Book; Sarah Eimerl; Assaf Bahat; Bin Lu; Sergei Braun; Michael R Maurizi; Carolyn K Suzuki; Ariella Oppenheim; Joseph Orly
Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2164-77.
2007: Noa Sher; Natalie Yivgi-Ohana; Joseph Orly
Transcriptional regulation of the cholesterol side chain cleavage cytochrome P450 gene (CYP11A1) revisited: binding of GATA, cyclic adenosine 3',5'-monophosphate response element-binding protein and activating protein (AP)-1 proteins to a distal novel cluster of cis-regulatory elements potentiates AP-2 and steroidogenic factor-1-dependent gene expression in the rodent placenta and ovary.
Molecular endocrinology (Baltimore, Md.) 2007;21(4):948-62.
2007: Zvi Granot; Naomi Melamed-Book; Assaf Bahat; Joseph Orly
Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.
Molecular and cellular endocrinology 2007;265-266():51-8.
2006: Eyal Arbely; Zvi Granot; Itamar Kass; Joseph Orly; Isaiah T Arkin
A trimerizing GxxxG motif is uniquely inserted in the severe acute respiratory syndrome (SARS) coronavirus spike protein transmembrane domain.
Biochemistry 2006;45(38):11349-56.
2006: Eran Silverman; Natalie Yivgi-Ohana; Noa Sher; Michal Bell; Sarah Eimerl; Joseph Orly
Transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene: GATA-4 and CCAAT/enhancer-binding protein beta confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models.
Molecular and cellular endocrinology 2006;252(1-2):92-101.
2006: Noa Sher; Joseph Orly
Analysis of trophoblast giant cell steroidogenesis in primary cultures.
Methods in molecular medicine 2006;122():301-19.
2005: XingJia Wang; chengli shen; Matthew T Dyson; Sarah Eimerl; Joseph Orly; James C Hutson; Douglas M Stocco
Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis.
Endocrinology 2005;146(10):4202-8.
2005: Gabriela Ondrovicová; Tong Liu; Kamalendra Singh; Bin Tian; Hong Li; Oleksandr Gakh; Dusan Perecko; Jiri Janata; Zvi Granot; Joseph Orly; Eva Kutejová; Carolyn K Suzuki
Cleavage site selection within a folded substrate by the ATP-dependent lon protease.
The Journal of biological chemistry 2005;280(26):25103-10.
2005: Ronit Haimov-Kochman; Diana Prus; Eyal Zcharia; Debra Goldman-Wohl; Shira Natanson-Yaron; Caryn Greenfield; Eyal Y Anteby; Reuven Reich; Joseph Orly; Alex Tsafriri; Arye Hurwitz; Israel Vlodavsky; Simcha Yagel
Spatiotemporal expression of heparanase during human and rodent ovarian folliculogenesis.
Biology of reproduction 2005;73(1):20-8.
2003: Zvi Granot; Ruth Geiss-Friedlander; Naomi Melamed-Book; Sarah Eimerl; Rina Timberg; Aryeh M Weiss; Karen Held Hales; Dale Buchanan Hales; Douglas M Stocco; Joseph Orly
Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2461-76.
2002: Zvi Granot; Eran Silverman; Ruth Friedlander; Naomi Melamed-Book; Sarah Eimerl; Rina Timberg; Karen Held Hales; Dale Buchanan Hales; Douglas M Stocco; Joseph Orly
The life cycle of the steroidogenic acute regulatory (StAR) protein: from transcription through proteolysis.
Endocrine research 2002;28(4):375-86.
2002: Tomohiro Ishii; Tomonobu Hasegawa; Chin-I Pai; Natalie Yvgi-Ohana; Rina Timberg; Liping Zhao; Gregor Majdic; Bon-Chu Chung; Joseph Orly; Keith L Parker
The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein.
Molecular endocrinology (Baltimore, Md.) 2002;16(10):2297-309.
2002: Sarah Eimerl; Joseph Orly
Regulation of steroidogenic genes by insulin-like growth factor-1 and follicle-stimulating hormone: differential responses of cytochrome P450 side-chain cleavage, steroidogenic acute regulatory protein, and 3beta-hydroxysteroid dehydrogenase/isomerase in rat granulosa cells.
Biology of reproduction 2002;67(3):900-10.
2002: Micha Ben-Zimra; Moriah Koler; Joseph Orly
Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1864-80.
2002: Micha Ben-Zimra; Moriah Koler; Naomi Melamed-Book; Jonathan Arensburg; Anita H Payne; Joseph Orly
Uterine and placental expression of steroidogenic genes during rodent pregnancy.
Molecular and cellular endocrinology 2002;187(1-2):223-31.
2002: Lihong Peng; Jonathan Arensburg; Joseph Orly; Anita H Payne
The murine 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene family: a postulated role for 3beta-HSD VI during early pregnancy.
Molecular and cellular endocrinology 2002;187(1-2):213-21.
2001: Douglas M Stocco; Barbara J Clark; AJ Reinhart; Simon Williams; Matthew T Dyson; B Dassi; Lance P Walsh; Pulak R Manna; Xing Jia Wang; A J Zeleznik; Joseph Orly
Elements involved in the regulation of the StAR gene.
Molecular and cellular endocrinology 2001;177(1-2):55-9.
2000: Sarit Larisch; Y Yi; Rona Lotan; Hedviga Kerner; Sarah Eimerl; W Tony Parks; Yossi Gottfried; S Birkey Reffey; Mark de Caestecker; David Danielpour; N Book-Melamed; Rina Timberg; Colin S Duckett; Robert J Lechleider; Hermann Steller; Joseph Orly; S J Kim; Anita B Roberts
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Nature cell biology 2000;2(12):915-21.
1999: Jonathan Arensburg; Anita H Payne; Joseph Orly
Expression of steroidogenic genes in maternal and extraembryonic cells during early pregnancy in mice.
Endocrinology 1999;140(11):5220-32.
1999: Joseph Orly; D M Stocco
The role of the steroidogenic acute regulatory (StAR) protein in female reproductive tissues.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(7):389-98.
1999: Michael Gal; Talia Eldar-Geva; Ehud J Margalioth; I Barr; Joseph Orly; Yoram Diamant
Attenuation of ovarian response by low-dose ketoconazole during superovulation in patients with polycystic ovary syndrome.
Fertility and sterility 1999;72(1):26-31.
1999: Eran Silverman; Sarah Eimerl; Joseph Orly
CCAAT enhancer-binding protein beta and GATA-4 binding regions within the promoter of the steroidogenic acute regulatory protein (StAR) gene are required for transcription in rat ovarian cells.
The Journal of biological chemistry 1999;274(25):17987-96.
1999: Steven R King; Z Liu; J Soh; Sarah Eimerl; Joseph Orly; Douglas M Stocco
Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic Acute Regulatory (StAR) protein.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):143-54.
1998: XingJia Wang; Z Liu; Sarah Eimerl; Rina Timberg; Aryeh M Weiss; Joseph Orly; Douglas M Stocco
Effect of truncated forms of the steroidogenic acute regulatory protein on intramitochondrial cholesterol transfer.
Endocrinology 1998;139(9):3903-12.
1998: Steven R King; F F G Rommerts; S L Ford; James C Hutson; Joseph Orly; Douglas M Stocco
Ethane dimethane sulfonate and NNN'N'-tetrakis-(2-pyridylmethyl)ethylenediamine inhibit steroidogenic acute regulatory (StAR) protein expression in MA-10 Leydig cells and rat Sertoli cells.
Endocrine research 1998;24(3-4):469-78.
1998: David Lichtstein; Michael Steinitz; Irith Gati; S Samuelov; Joseph Deutsch; Joseph Orly
Bufodienolides as endogenous Na+, K+-ATPase inhibitors: biosynthesis in bovine and rat adrenals.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(5-6):573-9.
1998: David Lichtstein; Michael Steinitz; Irith Gati; S Samuelov; Joseph Deutsch; Joseph Orly
Biosynthesis of digitalis-like compounds in rat adrenal cells: hydroxycholesterol as possible precursor.
Life sciences 1998;62(23):2109-26.
1998: T Ronen-Fuhrmann; Rina Timberg; Steven R King; Karen Held Hales; Dale Buchanan Hales; Douglas M Stocco; Joseph Orly
Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary.
Endocrinology 1998;139(1):303-15.
1997: I G Abbaszade; Jonathan Arensburg; C H Park; Josephine Z Kasa-Vubu; Joseph Orly; Anita H Payne
Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy.
Endocrinology 1997;138(4):1392-9.
1997: Nadia Cherradi; Michel F Rossier; Michel B Vallotton; Rina Timberg; I Friedberg; Joseph Orly; X J Wang; Douglas M Stocco; Alessandro M Capponi
Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells.
The Journal of biological chemistry 1997;272(12):7899-907.
1995: Steven R King; T Ronen-Fuhrmann; Rina Timberg; B J Clark; Joseph Orly; Douglas M Stocco
Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein.
Endocrinology 1995;136(11):5165-76.
1994: Michael Gal; Joseph Orly; I Barr; Nurit Algur; R Boldes; Yoram Diamant
Low dose ketoconazole attenuates serum androgen levels in patients with polycystic ovary syndrome and inhibits ovarian steroidogenesis in vitro.
Fertility and sterility 1994;61(5):823-32.
1993: R Schiff; Jonathan Arensburg; Ahuva Itin; Eli Keshet; Joseph Orly
Expression and cellular localization of uterine side-chain cleavage cytochrome P450 messenger ribonucleic acid during early pregnancy in mice.
Endocrinology 1993;133(2):529-37.
1993: S Gomberg-Malool; R Ziv; Y Re'em; I Posner; Alexander Levitzki; Joseph Orly
Tyrphostins inhibit follicle-stimulating hormone-mediated functions in cultured rat ovarian granulosa cells.
Endocrinology 1993;132(1):362-70.
1991: Michael Gal; I Barr; O Lior; OP Tadmor; Joseph Orly; Yoram Diamant
Effect of ketoconazole on steroidogenic human granulosa-luteal cells in culture.
European journal of obstetrics, gynecology, and reproductive biology 1991;39(3):209-14.
1989: S Bitzur; Joseph Orly
Microanalysis of hormone responsive ovarian interstitial gland cells in miniature culture.
Endocrinology 1989;124(3):1471-84.
1989: Joseph Orly
Orchestrated expression of steroidogenic side-chain cleavage cytochrome P-450 during follicular development in the rat ovary.
Journal of reproduction and fertility. Supplement 1989;37():155-62.
1989: D Goldschmit; P Kraicer; Joseph Orly
Periovulatory expression of cholesterol side-chain cleavage cytochrome P-450 in cumulus cells.
Endocrinology 1989;124(1):369-78.
1988: Y Farkash; Hermona Soreq; Joseph Orly
Biosynthesis of catalytically active rat testosterone 5 alpha-reductase in microinjected Xenopus oocytes: evidence for tissue-specific differences in translatable mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5824-8.
1987: N B Goldring; J M Durica; J Lifka; L Hedin; S L Ratoosh; W L Miller; Joseph Orly; J S Richards
Cholesterol side-chain cleavage P450 messenger ribonucleic acid: evidence for hormonal regulation in rat ovarian follicles and constitutive expression in corpora lutea.
Endocrinology 1987;120(5):1942-50.
1986: T Zlotkin; Y Farkash; Joseph Orly
Cell-specific expression of immunoreactive cholesterol side-chain cleavage cytochrome P-450 during follicular development in the rat ovary.
Endocrinology 1986;119(6):2809-20.
1986: N B Goldring; Y Farkash; D Goldschmit; Joseph Orly
Immunofluorescent probing of the mitochondrial cholesterol side-chain cleavage cytochrome P-450 expressed in differentiating granulosa cells in culture.
Endocrinology 1986;119(6):2821-32.
1986: Y Farkash; Rina Timberg; Joseph Orly
Preparation of antiserum to rat cytochrome P-450 cholesterol side chain cleavage, and its use for ultrastructural localization of the immunoreactive enzyme by protein A-gold technique.
Endocrinology 1986;118(4):1353-65.
1985: R Epstein-Almog; Joseph Orly
Inhibition of hormone-induced steroidogenesis during cell proliferation in serum-free cultures of rat granulosa cells.
Endocrinology 1985;116(5):2103-12.
1985: N B Goldring; Joseph Orly
Concerted metabolism of steroid hormones produced by cocultured ovarian cell types.
The Journal of biological chemistry 1985;260(2):913-21.
1984: P Weinberger-Ohana; D Goldschmit; L Mizrachi; Joseph Orly
Cyclic nucleotide phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, induces cytodifferentiation of follicular granulosa cells cultured in serum-free medium.
Endocrinology 1984;115(6):2160-9.
1984: P Weinberger-Ohana; R Shoshani; Y Farkash; N Hershkovits; N B Goldring; R Epstein-Almog; Joseph Orly
Low molecular weight substance from rat ovary induces steroidogenesis in cultured granulosa cells.
Molecular and cellular endocrinology 1984;36(1-2):141-55.
1982: Joseph Orly; Y Farkash; N Hershkovits; L Mizrahi; P Weinberger
Ovarian substance induces steroid production in cultured granulosa cells.
In vitro 1982;18(12):980-9.