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Ian Orme

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Bagganahalli S Somashekar; Pratima Tripathi; Anita G Amin; Randall Basaraba; Marcela Henao Tamayo; Midori Kato-Maeda; Neil MacKinnon; Diane Ordway; Ian M Orme; Ayyalusamy Ramamoorthy; Christopher D Rithner; Crystal A Shanley; Delphi Chatterjee
Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis.
Marcela Henao Tamayo; Andrés Obregón-Henao; Diane Ordway; Colleen G Duncan; Shaobin Shang; Ian M Orme
A mouse model of tuberculosis reinfection.
Shaobin Shang; Crystal A Shanley; David Ackart; Megan L Caraway; Laurel Hascall-Dove; Marcela Henao Tamayo; Diane Ordway; Eileen A Orme; Ian M Orme; Randall J Basaraba
Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis.

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2012: Bagganahalli S Somashekar; Pratima Tripathi; Anita G Amin; Randall Basaraba; Marcela Henao Tamayo; Midori Kato-Maeda; Neil MacKinnon; Diane Ordway; Ian M Orme; Ayyalusamy Ramamoorthy; Christopher D Rithner; Crystal A Shanley; Delphi Chatterjee
Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis.
Journal of proteome research 2012;11(10):4873-84.
2012: Marcela Henao Tamayo; Andrés Obregón-Henao; Diane Ordway; Colleen G Duncan; Shaobin Shang; Ian M Orme
A mouse model of tuberculosis reinfection.
Tuberculosis (Edinburgh, Scotland) 2012;92(3):211-7.
2012: Shaobin Shang; Crystal A Shanley; David Ackart; Megan L Caraway; Laurel Hascall-Dove; Marcela Henao Tamayo; Diane Ordway; Eileen A Orme; Ian M Orme; Randall J Basaraba
Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis.
Vaccine 2012;30(9):1572-82.
2012: Mary A De Groote; Janet C Gilliland; Veronica Gruppo; Ian M Orme; Lisa K Woolhiser; Anne J Lenaerts
Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2012;56(2):731-8.
2012: Gopinath Palanisamy; Crystal A Shanley; David F Ackart; Natalie M Kirk; Andrés Obregón-Henao; Ian M Orme; Randall J Basaraba
Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs.
PloS one 2012;7(3):e34148.
2011: Lance K Ching; Rhea N Coler; Jeffrey Guderian; Farah Mompoint; Ian M Orme; Alex Picone; Steven G Reed; Susan L Baldwin
Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.
Journal of immunological methods 2011;373(1-2):54-62.
2011: Kari A Sweeney; Manjunatha M Venkataswamy; Paras Jain; John Kim; Regy Lukose; Diane Ordway; Ian M Orme; Steven A Porcelli; Rani S Sellers; John Chan; Bing Chen; Mei Chen; Dee N Dao; Michael F Goldberg; Marcela Henao Tamayo; Tsungda Hsu; William R. Jacobs Jr.
A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis.
Nature medicine 2011;17(10):1261-8.
2011: Diane Ordway; Shaobin Shang; Crystal A Shanley; Randall J Basaraba; Megan Caraway; Colleen G Duncan; Marcela Henao Tamayo; Laura Nold; Andres Obregon-Henao; Ian M Orme
Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells.
Clinical and vaccine immunology : CVI 2011;18(9):1527-35.
2011: Shaobin Shang; Crystal A Shanley; Marcela Henao Tamayo; Ian M Orme; Gopinath Palanisamy; Randall J Basaraba; Megan Caraway; Edward D Chan; Marisa Harton; Diane Ordway
Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2011;91(5):378-85.
2011: Marcela Henao Tamayo; Scott M Irwin; Diane Ordway; Shaobin Shang; Ian M Orme
T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2011;91(4):308-13.
2011: Andrés Obregón-Henao; Crystal Shanley; María Verónica Bianco; Angel A Cataldi; Randall J Basaraba; Ian M Orme; Fabiana Bigi
Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis.
Vaccine 2011;29(26):4302-7.
2011: Shaobin Shang; Diane Ordway; Marcela Henao Tamayo; Xiyuan Bai; Rebecca Oberley-Deegan; Crystal A Shanley; Ian M Orme; Stephanie Case; Maisha Minor; David Ackart; Laurel Hascall-Dove; Alida R Ovrutsky; Pitchaimani Kandasamy; Dennis R Voelker; Cherie Lambert; Brian M Freed; Michael D Iseman; Randall J Basaraba; Edward D Chan
Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models.
The Journal of infectious diseases 2011;203(9):1240-8.
2011: Mary A De Groote; Janet C Gilliland; Colby L Wells; Elizabeth J Brooks; Lisa K Woolhiser; Veronica Gruppo; Charles A Peloquin; Ian M Orme; Anne J Lenaerts
Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2011;55(3):1237-47.
2011: Ian M Orme
Development of new vaccines and drugs for TB: limitations and potential strategic errors.
Future microbiology 2011;6(2):161-77.
2011: Gopinath Palanisamy; Crystal A Shanley; David F Ackart; Natalie M Kirk; Ian M Orme; Randall J Basaraba
Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis.
PloS one 2011;6(10):e26254.
2011: Adrian G Rosas-Taraco; David M Higgins; Joaquín Sánchez-Campillo; Eric J Lee; Ian M Orme; Mercedes González-Juarrero
Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice.
Tuberculosis (Edinburgh, Scotland) 2011;91(1):98-106.
2011: Shaobin Shang; Crystal A Shanley; Megan L Caraway; Eileen A Orme; Marcela Henao Tamayo; Laurel Hascall-Dove; David Ackart; Anne J Lenaerts; Randall J Basaraba; Ian M Orme; Diane Ordway
Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs.
Antimicrobial agents and chemotherapy 2011;55(1):124-31.
2010: Ian M Orme
The Achilles heel of BCG.
Tuberculosis (Edinburgh, Scotland) 2010;90(6):329-32.
2010: Diane Ordway; Crystal A Shanley; Megan L Caraway; Eileen A Orme; Daniel S Bucy; Laurel Hascall-Dove; Marcela Henao Tamayo; Marisa R Harton; Shaobin Shang; David Ackart; Susan L Kraft; Anne J Lenaerts; Randall J Basaraba; Ian M Orme
Evaluation of standard chemotherapy in the guinea pig model of tuberculosis.
Antimicrobial agents and chemotherapy 2010;54(5):1820-33.
2010: Marcela I Henao-Tamayo; Diane Ordway; Scott M Irwin; Shaobin Shang; Crystal A Shanley; Ian M Orme
Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI 2010;17(4):618-25.
2009: Merideth A Early; Marta Lishnevsky; John M Gilchrist; David M Higgins; Ian M Orme; William A Muller; Mercedes Gonzalez-Juarerro; Alan R Schenkel
Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry.
Experimental and molecular pathology 2009;87(2):152-8.
2009: Adrian G Rosas-Taraco; David M Higgins; Joaquín Sánchez-Campillo; Eric J Lee; Ian M Orme; Mercedes González-Juarrero
Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.
American journal of respiratory cell and molecular biology 2009;41(2):136-45.
2009: Ian M Orme
Potential complications to TB vaccine testing in animal models.
Indian journal of experimental biology 2009;47(6):440-4.
2009: Gopinath S Palanisamy; Nancy M DuTeau; Kathleen D Eisenach; Donald M Cave; Susan A Theus; Barry N Kreiswirth; Randall J Basaraba; Ian M Orme
Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs.
Tuberculosis (Edinburgh, Scotland) 2009;89(3):203-9.
2009: Mercedes Gonzalez-Juarrero; Luke C Kingry; Diane Ordway; Marcela Henao Tamayo; Marisa Harton; Randall J Basaraba; William H Hanneman; Ian M Orme; Richard Slayden
Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.
American journal of respiratory cell and molecular biology 2009;40(4):398-409.
2009: Marcela Henao Tamayo; Gopinath S Palaniswamy; Erin E Smith; Crystal A Shanley; Baolin Wang; Ian M Orme; Randall J Basaraba; Nancy M DuTeau; Diane Ordway
Post-exposure vaccination against Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2009;89(2):142-8.
2009: David M Higgins; Joaquin Sanchez-Campillo; Adrian G Rosas-Taraco; Eric J Lee; Ian M Orme; Mercedes Gonzalez-Juarrero
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.
Tuberculosis (Edinburgh, Scotland) 2009;89(2):149-57.
2009: Lisa K Woolhiser; Donald R Hoff; Karen S Marietta; Ian M Orme; Anne J Lenaerts
Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.
Antimicrobial agents and chemotherapy 2009;53(1):306-8.
2008: Karim C El Kasmi; Joseph E Qualls; John T Pesce; Amber M Smith; Robert W Thompson; Marcela Henao Tamayo; Randall J Basaraba; Till König; Ulrike Schleicher; Mi-Sun Koo; Gilla Kaplan; Katherine A Fitzgerald; Elaine I Tuomanen; Ian M Orme; Thirumala-Devi Kanneganti; Christian Bogdan; Thomas A Wynn; Peter J Murray
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
Nature immunology 2008;9(12):1399-406.
2008: Donald R Hoff; Megan L Caraway; Elizabeth J Brooks; Emily R Driver; Gavin J Ryan; Charles A Peloquin; Ian M Orme; Randall J Basaraba; Anne J Lenaerts
Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2008;52(11):4137-40.
2008: Diane Ordway; Marcela Henao Tamayo; Crystal A Shanley; Erin E Smith; Gopinath Palanisamy; Baolin Wang; Randall J Basaraba; Ian M Orme
Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI 2008;15(8):1248-58.
2008: Gopinath S Palanisamy; Erin E Smith; Crystal A Shanley; Diane J Ordway; Ian M Orme; Randall J Basaraba
Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model.
Tuberculosis (Edinburgh, Scotland) 2008;88(4):295-306.
2008: Diane Ordway; Marcela Henao Tamayo; Erin Smith; Crystal A Shanley; Marisa Harton; Jolynn Troudt; Xiyuan Bai; Randall J Basaraba; Ian M Orme; Edward D Chan
Animal model of Mycobacterium abscessus lung infection.
Journal of leukocyte biology 2008;83(6):1502-11.
2008: David M Higgins; Joaquin Sanchez-Campillo; Adrian G Rosas-Taraco; Jonathan R Higgins; Eric J Lee; Ian M Orme; Mercedes Gonzalez-Juarrero
Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4892-900.
2008: Anne J Lenaerts; Casey Bitting; Lisa Woolhiser; Veronica Gruppo; Karen S Marietta; Christine M Johnson; Ian M Orme
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.
Antimicrobial agents and chemotherapy 2008;52(4):1513-5.
2008: Anne J Lenaerts; Mary Ann Degroote; Ian M Orme
Preclinical testing of new drugs for tuberculosis: current challenges.
Trends in microbiology 2008;16(2):48-54.
2008: Randall J Basaraba; Helle Bielefeldt-Ohmann; Ellie K Eschelbach; Claire Reisenhauer; Airn E Tolnay; Lauren C Taraba; Crystal A Shanley; Erin A Smith; Cathy L Bedwell; Elizabeth A Chlipala; Ian M Orme
Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig.
Tuberculosis (Edinburgh, Scotland) 2008;88(1):69-79.
2007: Ian M Orme; Mercedes Gonzalez-Juarrero
Animal models of M. tuberculosis Infection.
Current protocols in microbiology 2007;Chapter 10():Unit 10A.5.
2007: Diane Ordway; David M Higgins; Joaquin Sanchez-Campillo; John S Spencer; Marcela Henao Tamayo; Marisa Harton; Ian M Orme; Mercedes Gonzalez-Juarrero
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.
Journal of leukocyte biology 2007;82(5):1221-9.
2007: Marcela Henao Tamayo; Ana Paula Junqueira-Kipnis; Diane Ordway; Mercedes Gonzales-Juarrero; Graham R Stewart; Douglas B Young; Robert J Wilkinson; Randall J Basaraba; Ian M Orme
A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties.
Vaccine 2007;25(41):7153-9.
2007: Anne J Lenaerts; Donald Hoff; Sahar Aly; Stefan Ehlers; Koen Andries; Luis Cantarero; Ian M Orme; Randall J Basaraba
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
Antimicrobial agents and chemotherapy 2007;51(9):3338-45.
2007: Diane Ordway; Gopinath Palanisamy; Marcela Henao Tamayo; Erin E Smith; Crystal A Shanley; Ian M Orme; Randall J Basaraba
The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2532-41.
2007: Joseph Hinchey; Sunhee C Lee; Bo Y Jeon; Randall J Basaraba; Venkataswamy Manjunatha; Bing Chen; John Chan; Miriam Braunstein; Ian M Orme; Steven C Derrick; Sheldon L Morris; William R. Jacobs Jr.; Steven A Porcelli
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.
The Journal of clinical investigation 2007;117(8):2279-88.
2007: Baolin Wang; Marcela Henao Tamayo; Marisa Harton; Diane Ordway; Crystal A Shanley; Randall J Basaraba; Ian M Orme
A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis.
Clinical and vaccine immunology : CVI 2007;14(7):902-6.
2007: Diane Ordway; Marcela Henao Tamayo; Marisa Harton; Gopinath Palanisamy; Jolynn Troudt; Crystal A Shanley; Randall J Basaraba; Ian M Orme
The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):522-31.
2007: Lisa Woolhiser; Marcela Henao Tamayo; Baolin Wang; Veronica Gruppo; John Belisle; Anne J Lenaerts; Randall J Basaraba; Ian M Orme
In vivo adaptation of the Wayne model of latent tuberculosis.
Infection and immunity 2007;75(5):2621-5.
2007: Steven C Derrick; Teresa H Evering; Vasan K Sambandamurthy; Kripa V Jalapathy; Tsungda Hsu; Bing Chen; Mei Chen; Robert G Russell; Ana Paula Junqueira-Kipnis; Ian M Orme; Steven A Porcelli; William R. Jacobs Jr.; Sheldon L Morris
Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
Immunology 2007;120(2):192-206.
2006: Jennifer L Taylor; Jessica M Hattle; Steven A Dreitz; Jolynn Troudt; Linda S Izzo; Randall J Basaraba; Ian M Orme; Lynn M Matrisian; Angelo A Izzo
Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection.
Infection and immunity 2006;74(11):6135-44.
2006: Ana Paula Junqueira-Kipnis; Randall J Basaraba; Veronica Gruppo; Gopinath Palanisamy; Oliver C Turner; Tsungda Hsu; William R. Jacobs Jr.; Scott A Fulton; Scott M Reba; W Henry Boom; Ian M Orme
Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.
Immunology 2006;119(2):224-31.
2006: Randall J Basaraba; Erin E Smith; Crystal A Shanley; Ian M Orme
Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.
Infection and immunity 2006;74(9):5397-401.
2006: Randall J Basaraba; Deanna D Dailey; Christine T McFarland; Crystal A Shanley; Erin E Smith; David N McMurray; Ian M Orme
Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2006;86(5):386-94.
2006: Diane Ordway; Marisa Harton; Marcela Henao Tamayo; Rose Montoya; Ian M Orme; Mercedes Gonzalez-Juarrero
Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4931-9.
2006: Veronica Gruppo; Christine M Johnson; Karen S Marietta; Hataichanok Scherman; Erin E Zink; Dean Crick; Linda B Adams; Ian M Orme; Anne J Lenaerts
Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2006;50(4):1245-50.
2006: Randall J Basaraba; Angelo A Izzo; Lise Brandt; Ian M Orme
Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations.
Vaccine 2006;24(3):280-6.
2006: Ian M Orme
Preclinical testing of new vaccines for tuberculosis: a comprehensive review.
Vaccine 2006;24(1):2-19.
2006: Jae Seuk Park; Marcela Henao Tamayo; Mercedes Gonzalez-Juarrero; Ian M Orme; Diane Ordway
Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.
Journal of leukocyte biology 2006;79(1):80-6.
2006: Ian M Orme
Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination.
Tuberculosis (Edinburgh, Scotland) 2006;86(1):68-73.
2005: Andre Kipnis; Scott Irwin; Angelo A Izzo; Randall J Basaraba; Ian M Orme
Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population.
Infection and immunity 2005;73(11):7759-64.
2005: Christine M Johnson; Rajesh Pandey; Sadhna Sharma; G K Khuller; Randall J Basaraba; Ian M Orme; Anne J Lenaerts
Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2005;49(10):4335-8.
2005: Diane Ordway; Marcela Henao Tamayo; Ian M Orme; Mercedes Gonzalez-Juarrero
Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3873-81.
2005: Scott Irwin; Angelo A Izzo; Steven W Dow; Yasir A W Skeiky; Steven G Reed; Mark R Alderson; Ian M Orme
Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.
Infection and immunity 2005;73(9):5809-16.
2005: Jennifer L Taylor; Diane Ordway; Jolynn Troudt; Mercedes Gonzalez-Juarrero; Randall J Basaraba; Ian M Orme
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
Infection and immunity 2005;73(8):5189-93.
2005: Anne J Lenaerts; Christine M Johnson; Karen S Marrieta; Veronica Gruppo; Ian M Orme
Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs.
International journal of antimicrobial agents 2005;26(2):152-8.
2005: Yasir A W Skeiky; Mark R Alderson; Pamela J Ovendale; Yves Lobet; Wilfried Dalemans; Ian M Orme; Steven G Reed; Antonio Campos-Neto
Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41.
Vaccine 2005;23(30):3937-45.
2005: Anne J Lenaerts; Veronica Gruppo; Karen S Marietta; Christine M Johnson; Diane K Driscoll; Nicholas M Tompkins; Jerry D Rose; Robert C Reynolds; Ian M Orme
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.
Antimicrobial agents and chemotherapy 2005;49(6):2294-301.
2005: Ana Paula Junqueira-Kipnis; Andre Kipnis; Marcela Henao Tamayo; Marisa Harton; Mercedes Gonzalez-Juarrero; Randall J Basaraba; Ian M Orme
Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.
Immunology 2005;115(2):246-52.
2005: Mercedes Gonzalez-Juarrero; Jessica M Hattle; Angelo Izzo; Ana Paula Junqueira-Kipnis; Tae S Shim; Bruce C Trapnell; Andrea M Cooper; Ian M Orme
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.
Journal of leukocyte biology 2005;77(6):914-22.
2005: Ian M Orme
The use of animal models to guide rational vaccine design.
Microbes and infection / Institut Pasteur 2005;7(5-6):905-10.
2005: Ian M Orme
Current progress in tuberculosis vaccine development.
Vaccine 2005;23(17-18):2105-8.
2005: Ian M Orme
Tuberculosis vaccines: current progress.
Drugs 2005;65(17):2437-44.
2005: Angelo Izzo; Lise Brandt; Todd M. Lasco; Andre Kipnis; Ian M Orme
NIH pre-clinical screening program: overview and current status.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):25-8.
2005: Ian M Orme
Mouse and guinea pig models for testing new tuberculosis vaccines.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):13-7.
2004: Lise Brandt; Yasir A W Skeiky; Mark R Alderson; Yves Lobet; Wilfried Dalemans; Oliver C Turner; Randall J Basaraba; Angelo A Izzo; Todd M. Lasco; Philip L Chapman; Steven G Reed; Ian M Orme
The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs.
Infection and immunity 2004;72(11):6622-32.
2004: Susan L Kraft; Deanna Dailey; Matthew E Kovach; Karen L Stasiak; Jamie Bennett; Christine T McFarland; David N McMurray; Angelo A Izzo; Ian M Orme; Randall J Basaraba
Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.
Infection and immunity 2004;72(10):5963-71.
2004: Bridget Vesosky; Oliver C Turner; Joanne Turner; Ian M Orme
Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan.
Infection and immunity 2004;72(8):4612-8.
2004: Joanne Turner; Karen M Dobos; Marc A Keen; Anthony A Frank; Stefan Ehlers; Ian M Orme; John Belisle; Andrea M Cooper
A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival.
Infection and immunity 2004;72(7):3759-68.
2004: Yasir A W Skeiky; Mark R Alderson; Pamela J Ovendale; Jeffrey Guderian; Lise Brandt; Davin C Dillon; Antonio Campos-Neto; Yves Lobet; Wilfried Dalemans; Ian M Orme; Steven G Reed
Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7618-28.
2004: Shiping Wu; Susan T Howard; David L Lakey; Andre Kipnis; Buka Samten; Hassan Safi; Veronica Gruppo; Benjamin Wizel; Homayoun Shams; Randall J Basaraba; Ian M Orme; Peter F Barnes
The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo.
Molecular microbiology 2004;51(6):1551-62.
2004: Ian M Orme
Adaptive immunity to mycobacteria.
Current opinion in microbiology 2004;7(1):58-61.
2004: Todd M. Lasco; Oliver C Turner; Lynne Cassone; Isamu Sugawara; Hiroyuki Yamada; David N McMurray; Ian M Orme
Rapid accumulation of eosinophils in lung lesions in guinea pigs infected with Mycobacterium tuberculosis.
Infection and immunity 2004;72(2):1147-9.
2004: Ming-Ju Hsieh; Ana Paula Junqueira-Kipnis; A Hoeffer; Oliver C Turner; Ian M Orme
Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis.
Vaccine 2004;22(5-6):655-9.
2004: Anne J Lenaerts; Phillip L Chapman; Ian M Orme
Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates.
Tuberculosis (Edinburgh, Scotland) 2004;84(6):361-4.
2004: Karen M Dobos; John S Spencer; Ian M Orme; John Belisle
Proteomic approaches to antigen discovery.
Methods in molecular medicine 2004;94():3-17.
2004: Ana Paula Junqueira-Kipnis; Joanne Turner; Mercedes Gonzalez-Juarrero; Oliver C Turner; Ian M Orme
Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.
Infection and immunity 2004;72(1):570-5.
2003: Ana Paula Junqueira-Kipnis; Andre Kipnis; Amanda M Jamieson; Mercedes Gonzalez Juarrero; Andreas Diefenbach; David H Raulet; Joanne Turner; Ian M Orme
NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6039-45.
2003: Andre Kipnis; Randall J Basaraba; Joanne Turner; Ian M Orme
Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule.
Journal of leukocyte biology 2003;74(6):992-7.
2003: Joanne Turner; Oliver C Turner; Nick Baird; Ian M Orme; Christine L Wilcox; Susan L Baldwin
Influence of increased age on the development of herpes stromal keratitis.
Experimental gerontology 2003;38(10):1205-12.
2003: Mercedes Gonzalez-Juarrero; Tae Sun Shim; Andre Kipnis; Ana Paula Junqueira-Kipnis; Ian M Orme
Dynamics of macrophage cell populations during murine pulmonary tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3128-35.
2003: Oliver C Turner; Robert G Keefe; Isamu Sugawara; Hiroyuki Yamada; Ian M Orme
SWR mice are highly susceptible to pulmonary infection with Mycobacterium tuberculosis.
Infection and immunity 2003;71(9):5266-72.
2003: Andre Kipnis; Randall J Basaraba; Ian M Orme; Andrea M Cooper
Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis.
Immunology 2003;109(4):547-51.
2003: Bridget Vesosky; Oliver C Turner; Joanne Turner; Ian M Orme
Activation marker expression on bovine peripheral blood gammadelta T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine.
Developmental and comparative immunology 2003;27(5):439-47.
2003: Jennifer L Taylor; Oliver C Turner; Randall J Basaraba; John Belisle; Kris Huygen; Ian M Orme
Pulmonary necrosis resulting from DNA vaccination against tuberculosis.
Infection and immunity 2003;71(4):2192-8.
2003: Anne J Lenaerts; Veronica Gruppo; Jason V Brooks; Ian M Orme
Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice.
Antimicrobial agents and chemotherapy 2003;47(2):783-5.
2003: Oliver C Turner; Randall J Basaraba; Ian M Orme
Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis.
Infection and immunity 2003;71(2):864-71.
2003: T S Shim; Oliver C Turner; Ian M Orme
Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection.
Tuberculosis (Edinburgh, Scotland) 2003;83(6):367-71.
2003: Ian M Orme
The mouse as a useful model of tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2003;83(1-3):112-5.
2002: Joanne Turner; Mercedes Gonzalez-Juarrero; Debi L Ellis; Randall J Basaraba; Andre Kipnis; Ian M Orme; Andrea M Cooper
In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6343-51.
2002: Mercedes González-Juarrero; Joanne Turner; Randall J Basaraba; John Belisle; Ian M Orme
Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis.
Cellular immunology 2002;220(1):13-9.
2002: Lise Brandt; Ian M Orme
Prospects for new vaccines against tuberculosis.
BioTechniques 2002;33(5):1098, 1100, 1102.
2002: Veronica Gruppo; Oliver C Turner; Ian M Orme; Joanne Turner
Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis.
Microbiology (Reading, England) 2002;148(Pt 10):2959-66.
2002: Joanne Turner; Anthony A Frank; Ian M Orme
Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells.
Infection and immunity 2002;70(8):4628-37.
2002: Joanne Turner; Ian M Orme
Identification of altered integrin alpha/beta chain expression on T cells from old mice infected with Mycobacterium tuberculosis.
Experimental gerontology 2002;37(7):907-16.
2002: Bernadette M Saunders; Anthony A Frank; Ian M Orme; Andrea M Cooper
CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis.
Cellular immunology 2002;216(1-2):65-72.
2002: Andrea M Cooper; Andre Kipnis; Joanne Turner; Jeanne Magram; Jessica Ferrante; Ian M Orme
Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1322-7.
2002: Jordi B Torrelles; D Ellis; T Osborne; A Hoefer; Ian M Orme; Delphi Chatterjee; Patrick J Brennan; Andrea M Cooper
Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104.
Tuberculosis (Edinburgh, Scotland) 2002;82(6):293-300.
2002: Veronica Gruppo; Ian M Orme
Dose of BCG does not influence the efficient generation of protective immunity in mice challenged with Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2002;82(6):267-73.
2001: J E Pearl; B Saunders; S Ehlers; Ian M Orme; Andrea M Cooper
Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.
Cellular immunology 2001;211(1):43-50.
2001: Ian M Orme
The search for new vaccines against tuberculosis.
Journal of leukocyte biology 2001;70(1):1-10.
2001: Ian M Orme
Search for new drugs for treatment of tuberculosis.
Antimicrobial agents and chemotherapy 2001;45(7):1943-6.
2001: Ian M Orme; Alan D. Roberts
Animal models of mycobacteria infection.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 19():Unit 19.5.
2001: Joanne Turner; Mercedes Gonzalez-Juarrero; Bernadette M Saunders; Jason V Brooks; PM Marietta; D L Ellis; Anthony A Frank; Andrea M Cooper; Ian M Orme
Immunological basis for reactivation of tuberculosis in mice.
Infection and immunity 2001;69(5):3264-70.
2001: B A Covert; John S Spencer; Ian M Orme; John Belisle
The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis.
Proteomics 2001;1(4):574-86.
2001: Jason V Brooks; Anthony A Frank; Marc A Keen; J T Bellisle; Ian M Orme
Boosting vaccine for tuberculosis.
Infection and immunity 2001;69(4):2714-7.
2001: Joanne Turner; Anthony A Frank; Jason V Brooks; Mercedes Gonzalez-Juarrero; Ian M Orme
The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4.
Experimental gerontology 2001;36(3):537-45.
2001: Ian M Orme; David N McMurray; John Belisle
Tuberculosis vaccine development: recent progress.
Trends in microbiology 2001;9(3):115-8.
2001: Mercedes Gonzalez-Juarrero; Oliver C Turner; Joanne Turner; PM Marietta; Jason V Brooks; Ian M Orme
Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.
Infection and immunity 2001;69(3):1722-8.
2001: Joanne Turner; Anthony A Frank; Jason V Brooks; PM Marietta; Ian M Orme
Pentoxifylline treatment of mice with chronic pulmonary tuberculosis accelerates the development of destructive pathology.
Immunology 2001;102(2):248-53.
2001: Joanne Turner; Anthony A Frank; Jason V Brooks; PM Marietta; Bridget Vesosky; Ian M Orme
Tuberculosis in aged gammadelta T cell gene disrupted mice.
Experimental gerontology 2001;36(2):245-54.
2001: Mercedes Gonzalez-Juarrero; Ian M Orme
Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis.
Infection and immunity 2001;69(2):1127-33.
2001: Joanne Turner; CD D'Souza; J E Pearl; PM Marietta; M Noel; Anthony A Frank; Rui Appelberg; Ian M Orme; Andrea M Cooper
CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis.
American journal of respiratory cell and molecular biology 2001;24(2):203-9.
2001: Ian M Orme
Immunology and vaccinology of tuberculosis: can lessons from the mouse be applied to the cow?
Tuberculosis (Edinburgh, Scotland) 2001;81(1-2):109-13.
2000: Yasir A W Skeiky; Pamela J Ovendale; Shyian Jen; Mark R Alderson; Davin C Dillon; S Smith; C B Wilson; Ian M Orme; Steven G Reed; Antonio Campos-Neto
T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7140-9.
2000: Andrea M Cooper; J E Pearl; Jason V Brooks; Stefan Ehlers; Ian M Orme
Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung.
Infection and immunity 2000;68(12):6879-82.
2000: CD D'Souza; Andrea M Cooper; Anthony A Frank; S Ehlers; Joanne Turner; A Bendelac; Ian M Orme
A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung.
American journal of respiratory cell and molecular biology 2000;23(2):188-93.
2000: Oliver C Turner; Alan D. Roberts; Anthony A Frank; S W Phalen; D M McMurray; Jean Content; Olivier Denis; Sushila D'Souza; A Tanghe; Kris Huygen; Ian M Orme
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Infection and immunity 2000;68(6):3674-9.
2000: Bernadette M Saunders; Anthony A Frank; Ian M Orme; Andrea M Cooper
Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection.
Infection and immunity 2000;68(6):3322-6.
2000: Joanne Turner; ER Rhoades; Marc A Keen; John Belisle; Anthony A Frank; Ian M Orme
Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode.
Infection and immunity 2000;68(3):1706-9.
2000: Andrea M Cooper; B H Segal; Anthony A Frank; S M Holland; Ian M Orme
Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.
Infection and immunity 2000;68(3):1231-4.
2000: Jorge Pedrosa; Bernadette M Saunders; Rui Appelberg; Ian M Orme; Manuel T Silva; Andrea M Cooper
Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice.
Infection and immunity 2000;68(2):577-83.
2000: J E Pearl; Ian M Orme; Andrea M Cooper
CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2000;80(6):273-9.
1999: Bernadette M Saunders; Anthony A Frank; Ian M Orme
Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis.
Immunology 1999;98(3):324-8.
1999: Ian M Orme
Beyond BCG: the potential for a more effective TB vaccine.
Molecular medicine today 1999;5(11):487-92.
1999: Ian M Orme; John Belisle
TB vaccine development: after the flood.
Trends in microbiology 1999;7(10):394-5.
1999: Ian M Orme; Andrea M Cooper
Cytokine/chemokine cascades in immunity to tuberculosis.
Immunology today 1999;20(7):307-12.
1999: Davin C Dillon; Mark R Alderson; Craig H Day; David M Lewinsohn; Rhea N Coler; TT Bement; Antonio Campos-Neto; Yasir A W Skeiky; Ian M Orme; A Roberts; S Steen; Wilfried Dalemans; Roberto Badaro; Steven G Reed
Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family.
Infection and immunity 1999;67(6):2941-50.
1999: Jason V Brooks; S K Furney; Ian M Orme
Metronidazole therapy in mice infected with tuberculosis.
Antimicrobial agents and chemotherapy 1999;43(5):1285-8.
1999: Ian M Orme
New vaccines against tuberculosis. The status of current research.
Infectious disease clinics of North America 1999;13(1):169-85, vii-viii.
1999: Ian M Orme
Virulence of recent notorious Mycobacterium tuberculosis isolates.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999;79(6):379-81.
1999: Susan L Baldwin; CD D'Souza; Ian M Orme; Margaret A Liu; Kris Huygen; Olivier Denis; A Tang; L Zhu; D Montgomery; J B Ulmer
Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999;79(4):251-9.
1999: Ian M Orme
Vaccination against tuberculosis: recent progress.
Advances in veterinary medicine 1999;41():135-43.
1998: ER Rhoades; Ian M Orme
Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis.
Mechanisms of ageing and development 1998;106(1-2):145-53.
1998: Jason V Brooks; Ian M Orme
Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model.
Antimicrobial agents and chemotherapy 1998;42(11):3047-8.
1998: Bernadette M Saunders; Anthony A Frank; Andrea M Cooper; Ian M Orme
Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice.
Infection and immunity 1998;66(11):5508-14.
1998: Catharine M Bosio; Ian M Orme
Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice.
Infection and immunity 1998;66(10):5048-51.
1998: Alan D. Roberts; Ian M Orme
CD95 expression in aged mice infected with tuberculosis.
Infection and immunity 1998;66(10):5036-40.
1998: Ian M Orme; Alan D. Roberts
Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected with tuberculosis.
Mechanisms of ageing and development 1998;105(1-2):19-29.
1998: Andrea M Cooper; Rui Appelberg; Ian M Orme
Immunopathogenesis of Mycobacterium avium infection.
Frontiers in bioscience : a journal and virtual library 1998;3():e141-8.
1998: Susan L Baldwin; CD D'Souza; Alan D. Roberts; B P Kelly; Anthony A Frank; M A Lui; J B Ulmer; Kris Huygen; D M McMurray; Ian M Orme
Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis.
Infection and immunity 1998;66(6):2951-9.
1998: J DiTirro; ER Rhoades; Alan D. Roberts; J M Burke; A Mukasa; Andrea M Cooper; Anthony A Frank; Willi K Born; Ian M Orme
Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes.
Infection and immunity 1998;66(5):2284-9.
1998: C M Johnson; Andrea M Cooper; Anthony A Frank; Ian M Orme
Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis-infected mice with a disruption in the intracellular adhesion molecule 1 gene.
Infection and immunity 1998;66(4):1666-70.
1998: Ian M Orme
The immunopathogenesis of tuberculosis: a new working hypothesis.
Trends in microbiology 1998;6(3):94-7.
1998: Ian M Orme
Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection.
Novartis Foundation symposium 1998;217():112-7; discussion 117-9.
1997: Andrea M Cooper; Jeanne Magram; Jessica Ferrante; Ian M Orme
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis.
The Journal of experimental medicine 1997;186(1):39-45.
1997: Ian M Orme
Progress in the development of new vaccines against tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;1(2):95-100.
1997: M Florido; Rui Appelberg; Ian M Orme; Andrea M Cooper
Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium.
Immunology 1997;90(4):600-6.
1997: Andrea M Cooper; CD D'Souza; Anthony A Frank; Ian M Orme
The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms.
Infection and immunity 1997;65(4):1317-20.
1997: ER Rhoades; Ian M Orme
Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates.
Infection and immunity 1997;65(4):1189-95.
1997: CD D'Souza; Andrea M Cooper; Anthony A Frank; RJ Mazzaccaro; Barry R Bloom; Ian M Orme
An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1217-21.
1997: C M Johnson; Andrea M Cooper; Anthony A Frank; C B Bonorino; L J Wysoki; Ian M Orme
Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(5-6):257-61.
1997: Andrea M Cooper; J E Callahan; Marc A Keen; John Belisle; Ian M Orme
Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(1):67-73.
1997: ER Rhoades; Anthony A Frank; Ian M Orme
Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1997;78(1):57-66.
1996: Richard Slayden; Richard E Lee; J W Armour; A M Cooper; Ian M Orme; Patrick J Brennan; Gurdyal S Besra
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.
Antimicrobial agents and chemotherapy 1996;40(12):2813-9.
1996: B P Kelly; S K Furney; M T Jessen; Ian M Orme
Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 1996;40(12):2809-12.
1996: Kris Huygen; Jean Content; Olivier Denis; Donna L Montgomery; AM Yawman; RR Deck; CM DeWitt; Ian M Orme; S Baldwin; CD D'Souza; Annie Drowart; E Lozes; P Vandenbussche; Jean-Paul Van Vooren; Margaret A Liu; Jeffrey B Ulmer
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine.
Nature medicine 1996;2(8):893-8.
1995: Ian M Orme
Prospects for new vaccines against tuberculosis.
Trends in microbiology 1995;3(10):401-4.
1995: ER Rhoades; Andrea M Cooper; Ian M Orme
Chemokine response in mice infected with Mycobacterium tuberculosis.
Infection and immunity 1995;63(10):3871-7.
1995: Andrea M Cooper; J E Callahan; J P Griffin; Alan D. Roberts; Ian M Orme
Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis.
Infection and immunity 1995;63(9):3259-65.
1995: Alan D. Roberts; MG Sonnenberg; D J Ordway; S K Furney; Patrick J Brennan; John Belisle; Ian M Orme
Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis.
Immunology 1995;85(3):502-8.
1995: S K Furney; P S Skinner; J Farrer; Ian M Orme
Activities of rifabutin, clarithromycin, and ethambutol against two virulent strains of Mycobacterium avium in a mouse model.
Antimicrobial agents and chemotherapy 1995;39(3):786-9.
1995: P S Skinner; S K Furney; D A Kleinert; Ian M Orme
Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 1995;39(3):750-3.
1995: Andrea M Cooper; Alan D. Roberts; ER Rhoades; J E Callahan; Dave Getzy; Ian M Orme
The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.
Immunology 1995;84(3):423-32.
1995: D J Ordway; MG Sonnenberg; S A Donahue; John Belisle; Ian M Orme
Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice.
Infection and immunity 1995;63(2):741-3.
1994: P S Skinner; S K Furney; M R Jacobs; G Klopman; Jerrold Jay Ellner; Ian M Orme
A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions.
Antimicrobial agents and chemotherapy 1994;38(11):2557-63.
1994: Ian M Orme; Alan D. Roberts; S K Furney; P S Skinner
Animal and cell-culture models for the study of mycobacterial infections and treatment.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13(11):994-9.
1994: Rui Appelberg; A G Castro; J Pedrosa; RA Silva; Ian M Orme; P Minóprio
Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection.
Infection and immunity 1994;62(9):3962-71.
1994: Ian M Orme; S K Furney; P S Skinner; AD Roberts; Patrick J Brennan; D G Russell; Hiroe Clerk Shiratsuchi; Jerrold Jay Ellner; W Y Weiser
Inhibition of growth Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
Infection and immunity 1994;62(5):2141.
1994: J P Griffin; Ian M Orme
Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis.
Infection and immunity 1994;62(5):1683-90.
1993: Rui Appelberg; Ian M Orme
Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages.
Immunology 1993;80(3):352-9.
1993: Ian M Orme
Immunity to mycobacteria.
Current opinion in immunology 1993;5(4):497-502.
1993: Ian M Orme; Alan D. Roberts; J P Griffin; J S Abrams
Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):518-25.
1993: Ian M Orme
The role of CD8+ T cells in immunity to tuberculosis infection.
Trends in microbiology 1993;1(3):77-8.
1993: Alan D. Roberts; D J Ordway; Ian M Orme
Listeria monocytogenes infection in beta 2 microglobulin-deficient mice.
Infection and immunity 1993;61(3):1113-6.
1993: Ian M Orme; J P Griffin; Alan D. Roberts; D N Ernst
Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis.
Cellular immunology 1993;147(1):222-9.
1993: Ian M Orme; S K Furney; P S Skinner; AD Roberts; Patrick J Brennan; D G Russell; Hiroe Clerk Shiratsuchi; Jerrold Jay Ellner; W Y Weiser
Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor.
Infection and immunity 1993;61(1):338-42.
1992: Ian M Orme; S K Furney; Alan D. Roberts
Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses.
Infection and immunity 1992;60(11):4747-53.
1992: S K Furney; P S Skinner; Alan D. Roberts; Rui Appelberg; Ian M Orme
Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor.
Infection and immunity 1992;60(10):4410-3.
1992: Rui Appelberg; Ian M Orme; M I Pinto de Sousa; M T Silva
In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation.
Immunology 1992;76(4):553-9.
1992: Ian M Orme; Delphi Chatterjee
Antibody levels to the type-specific glycopeptidolipid antigens of Mycobacterium avium in homosexual men: possible implications.
Research in microbiology 1992;143(4):381-5.
1992: Delphi Chatterjee; Alan D. Roberts; karen lowell; Patrick J Brennan; Ian M Orme
Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor.
Infection and immunity 1992;60(3):1249-53.
1992: Ian M Orme; E S Miller; Alan D. Roberts; S K Furney; J P Griffin; K M Dobos; D Chi; B Rivoire; Patrick J Brennan
T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):189-96.
1991: Ian M Orme
Processing and presentation of mycobacterial antigens: implications for the development of a new improved vaccine for tuberculosis control.
Tubercle 1991;72(4):250-2.
1991: J P Griffin; K V Harshan; Willi K Born; Ian M Orme
Kinetics of accumulation of gamma delta receptor-bearing T lymphocytes in mice infected with live mycobacteria.
Infection and immunity 1991;59(11):4263-5.
1991: B Y Lee; Delphi Chatterjee; C M Bozic; Patrick J Brennan; D L Cohn; J D Bales; S M Harrison; L A Andron; Ian M Orme
Prevalence of serum antibody to the type-specific glycopeptidolipid antigens of Mycobacterium avium in human immunodeficiency virus-positive and -negative individuals.
Journal of clinical microbiology 1991;29(5):1026-9.
1991: Ian M Orme; B Y Lee; Rui Appelberg; E S Miller; D L Chi; J P Griffin; Alan D. Roberts
T cell response in acquired protective immunity to Mycobacterium tuberculosis infection.
Bulletin of the International Union against Tuberculosis and Lung Disease 1991;66(1):7-13.
1990: S K Furney; Alan D. Roberts; Ian M Orme
Effect of rifabutin on disseminated Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient mice.
Antimicrobial agents and chemotherapy 1990;34(9):1629-32.
1989: Ian M Orme
Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations.
Immunology 1989;68(1):93-5.
1989: E S Miller; Ian M Orme
Patterns of IL-2 production and utilization in mice heavily infected with Mycobacterium bovis BCG reflect the phase of protective immunity being expressed.
Immunology 1989;67(2):221-4.
1989: Ian M Orme
Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes.
Cellular immunology 1989;118(1):229-33.
1988: Ian M Orme
An age-related loss of the isogeneic barrier to the successful passive cell transfer of antimicrobial immunity in mice.
Mechanisms of ageing and development 1988;46(1-3):29-32.
1988: Ian M Orme
Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccines.
Infection and immunity 1988;56(12):3310-2.
1988: Ian M Orme
Antimycobacterial activity in vivo of LM427 (rifabutin).
The American review of respiratory disease 1988;138(5):1254-7.
1988: T J Cummins; Ian M Orme; R E Smith
Reduced in vivo nonspecific resistance to Listeria monocytogenes infection during avian retrovirus-induced immunosuppression.
Avian diseases 1988;32(4):663-7.
1988: Ian M Orme
Evidence for a biphasic memory T-cell response to high dose BCG vaccination in mice.
Tubercle 1988;69(2):125-31.
1988: Ian M Orme
Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3589-93.
1988: Ian M Orme
A mouse model of the recrudescence of latent tuberculosis in the elderly.
The American review of respiratory disease 1988;137(3):716-8.
1988: Ian M Orme
The immune response to the cell wall of Mycobacterium bovis BCG.
Clinical and experimental immunology 1988;71(3):388-93.
1987: E C Roberts; James DeMartini; Ian M Orme
Passive transfer of acquired resistance to Listeria monocytogenes infection is independent of mononuclear cell granuloma formation.
Infection and immunity 1987;55(12):3215-8.
1987: Ian M Orme
The dynamics of infection following BCG and Mycobacterium tuberculosis challenge in T-cell-deficient mice.
Tubercle 1987;68(4):277-83.