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David Ornitz

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Sung-Ho Huh; Päivi H Lindfors; Katja Närhi; David M Ornitz; Lu Yang; Otso Häärä; Marja L Mikkola
Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.
Congxing Lin; Sheila M Bell; Hong Chen; Sung-Ho Huh; David M Ornitz; G Michael Veith; Yan Yin; Liang Ma
Delineating a conserved genetic cassette promoting outgrowth of body appendages.
Fanxin Long; David M Ornitz
Development of the endochondral skeleton.

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2013: Sung-Ho Huh; Päivi H Lindfors; Katja Närhi; David M Ornitz; Lu Yang; Otso Häärä; Marja L Mikkola
Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.
Genes & development 2013;27(4):450-8.
2013: Congxing Lin; Sheila M Bell; Hong Chen; Sung-Ho Huh; David M Ornitz; G Michael Veith; Yan Yin; Liang Ma
Delineating a conserved genetic cassette promoting outgrowth of body appendages.
PLoS genetics 2013;9(1):e1003231.
2013: Fanxin Long; David M Ornitz
Development of the endochondral skeleton.
Cold Spring Harbor perspectives in biology 2013;5(1):a008334.
2012: Otso Häärä; Enni Harjunmaa; Sung-Ho Huh; Jukka Jernvall; Päivi H Lindfors; Marja L Mikkola; David M Ornitz; Ingrid Fliniaux; Thomas Aberg; Irma Thesleff
Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
Development (Cambridge, England) 2012;139(17):3189-99.
2012: Hila Barak; Christine Bole-Feysot; Shuang Chen; Sung-Ho Huh; Cécile Jeanpierre; Jelena Martinovic; Patrick Nitschké; David M Ornitz; Mélanie Parisot; Rémi Salomon; Corinne Antignac; Raphael Kopan
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Developmental cell 2012;22(6):1191-207.
2012: David M Ornitz; Yongjun Yin
Signaling networks regulating development of the lower respiratory tract.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2011: Mónica Vega-Hernández; Stijn De Langhe; Attila Kovacs; David M Ornitz
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.
Development (Cambridge, England) 2011;138(15):3331-40.
2011: Yongjun Yin; Fen Wang; David M Ornitz
Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development.
Development (Cambridge, England) 2011;138(15):3169-77.
2011: Kai Yu; David M Ornitz
Histomorphological study of palatal shelf elevation during murine secondary palate formation.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(7):1737-44.
2011: Euysoo Kim; Krzysztof L Hyrc; Judith Speck; Felipe T Salles; Yunxia W Lundberg; Mark P Goldberg; Anne E White-Olson; Mark E Warchol; David M Ornitz
Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells.
Molecular and cellular neurosciences 2011;46(3):655-61.
2011: Nobuyuki Itoh; David M Ornitz
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.
Journal of biochemistry 2011;149(2):121-30.
2010: Euysoo Kim; Krzysztof L Hyrc; Judith Speck; Yunxia W Lundberg; Felipe T Salles; Anne E White-Olson; Mark P Goldberg; Mark E Warchol; David M Ornitz
Regulation of cellular calcium in vestibular supporting cells by otopetrin 1.
Journal of neurophysiology 2010;104(6):3439-50.
2010: Wenfu Lu; Dan Zhou; John J Freeman; Isolde Thalmann; David M Ornitz; Ruediger Thalmann
In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.
Hearing research 2010;268(1-2):172-83.
2010: Mario D Martinez; Gregory J Schmid; Jennifer A McKenzie; David M Ornitz; Matthew J Silva
Healing of non-displaced fractures produced by fatigue loading of the mouse ulna.
Bone 2010;46(6):1604-12.
2010: Sung-Ho Huh; David M Ornitz
Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1.
Development (Cambridge, England) 2010;137(7):1137-47.
2010: Alison K Snyder-Warwick; Chad A Perlyn; Jing Pan; Kai Yu; Lijuan Zhang; David M Ornitz
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2515-20.
2009: Fernanda Laezza; Angelika Lampert; Marie A Kozel; Benjamin R Gerber; Anthony M Rush; Jeanne M Nerbonne; Stephen G Waxman; Sulayman D Dib-Hajj; David M Ornitz
FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.
Molecular and cellular neurosciences 2009;42(2):90-101.
2009: Juliya Kalinina; Sara Byron; Helen P Makarenkova; Shaun K Olsen; Anna V Eliseenkova; William J Larochelle; Mohanraj Dhanabal; Steven Blais; David M Ornitz; Loren A Day; Thomas A Neubert; Pam Pollock; Moosa Mohammadi
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.
Molecular and cellular biology 2009;29(17):4663-78.
2009: Regina Goetz; Katarzyna Dover; Fernanda Laezza; Nataly Shtraizent; Xiao Huang; Dafna Tchetchik; Anna V Eliseenkova; Chong-Feng Xu; Thomas A Neubert; David M Ornitz; mitchell goldfarb; Moosa Mohammadi
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
The Journal of biological chemistry 2009;284(26):17883-96.
2009: Gregory J Schmid; Chikashi Kobayashi; Linda J Sandell; David M Ornitz
Fibroblast growth factor expression during skeletal fracture healing in mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(3):766-74.
2009: Kory J Lavine; David M Ornitz
Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.
Circulation research 2009;104(2):159-69.
2008: Kory J Lavine; Fanxin Long; Kyunghee Choi; Craig Smith; David M Ornitz
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development.
Development (Cambridge, England) 2008;135(18):3161-71.
2008: Michael J Geske; Xiuqin Zhang; Khushbu K Patel; David M Ornitz; Thaddeus S Stappenbeck
Fgf9 signaling regulates small intestinal elongation and mesenchymal development.
Development (Cambridge, England) 2008;135(17):2959-68.
2008: Yongjun Yin; Andrew C White; Sung-Ho Huh; Matthew J Hilton; Hidemi Kanazawa; Fanxin Long; David M Ornitz
An FGF-WNT gene regulatory network controls lung mesenchyme development.
Developmental biology 2008;319(2):426-36.
2008: Kory J Lavine; Attila Kovacs; David M Ornitz
Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.
The Journal of clinical investigation 2008;118(7):2404-14.
2008: Haotian Zhao; Tianyu Yang; Bhavani P Madakashira; Cornelius A Thiels; Chad A Bechtle; Claudia M Garcia; Huiming Zhang; Kai Yu; David M Ornitz; David C Beebe; Michael L Robinson
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.
Developmental biology 2008;318(2):276-88.
2008: Morichika Konishi; Hirotoshi Nakamura; Hiroyuki Miwa; Pierre Chambon; David M Ornitz; Nobuyuki Itoh
Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue.
Molecular and cellular endocrinology 2008;287(1-2):13-9.
2008: Kory J Lavine; Gregory J Schmid; Craig S Smith; David M Ornitz
Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(3):713-24.
2008: Kai Yu; David M Ornitz
FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.
Development (Cambridge, England) 2008;135(3):483-91.
2008: Inna Hughes; Jonathan Binkley; Belen Hurle; Eric Green; Arend Sidow; David M Ornitz
Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.
BMC evolutionary biology 2008;8():41.
2008: Nobuyuki Itoh; David M Ornitz
Functional evolutionary history of the mouse Fgf gene family.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(1):18-27.
2008: Kory J Lavine; David M Ornitz
Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center.
Trends in genetics : TIG 2008;24(1):33-40.
2007: Fernanda Laezza; Benjamin R Gerber; Jun-Yang Lou; Marie A Kozel; Hali Hartman; Ann Marie Craig; David M Ornitz; Jeanne M Nerbonne
The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):12033-44.
2007: Andrew C White; Kory J Lavine; David M Ornitz
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.
Development (Cambridge, England) 2007;134(20):3743-52.
2007: Jonna Saarimäki-Vire; Paula Peltopuro; Laura Lahti; Thorsten Naserke; Alexandra A Blak; Daniela Vogt Weisenhorn; Kai Yu; David M Ornitz; Wolfgang Wurst; Juha Partanen
Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(32):8581-92.
2007: mitchell goldfarb; Jon Schoorlemmer; Anthony Williams; Shyam Diwakar; Qing Wang; Xiao Huang; Joanna Giza; Dafna Tchetchik; Kevin Kelley; Ana Vega; Gary Matthews; Paola Rossi; David M Ornitz; Egidio D'Angelo
Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.
Neuron 2007;55(3):449-63.
2007: Inna Hughes; Mitsuyoshi Saito; Paul H Schlesinger; David M Ornitz
Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12023-8.
2007: Irene H Hung; Kai Yu; Kory J Lavine; David M Ornitz
FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.
Developmental biology 2007;307(2):300-13.
2007: Kory J Lavine; David M Ornitz
Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization.
Trends in cardiovascular medicine 2007;17(3):77-83.
2007: David F Wozniak; Maolei Xiao; Lin Xu; Kelvin A Yamada; David M Ornitz
Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14.
Neurobiology of disease 2007;26(1):14-26.
2007: simone ml smith; Leigh A West; Prasanthi Govindraj; Xiuqin Zhang; David M Ornitz; John R Hassell
Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(3):175-84.
2007: Maolei Xiao; Lin Xu; Fernanda Laezza; Kelvin Yamada; Sheng Feng; David M Ornitz
Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14.
Molecular and cellular neurosciences 2007;34(3):366-77.
2007: Yongshun Lin; Guoqin Liu; Yongyou Zhang; Ya-Ping Hu; Kai Yu; Chunhong Lin; Kerstin McKeehan; Jim W Xuan; David M Ornitz; Michael M Shen; Norman Greenberg; Wallace L McKeehan; Fen Wang
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.
Development (Cambridge, England) 2007;134(4):723-34.
2007: Zhonghao Liu; Kory J Lavine; Irene H Hung; David M Ornitz
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Developmental biology 2007;302(1):80-91.
2006: Y Kaga; W J Shoemaker; M Furusho; M Bryant; J Rosenbluth; Steven E Pfeiffer; L Oh; Matthew N Rasband; Corinna Lappe-Siefke; K Yu; David M Ornitz; Klaus-Armin Nave; Rashmi Bansal
Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(47):12339-50.
2006: Eiichi Hinoi; Peter Bialek; You-Tzung Chen; Marie-Therese Rached; Yoram Groner; Richard R Behringer; David M Ornitz; Gerard Karsenty
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.
Genes & development 2006;20(21):2937-42.
2006: Changwon Park; Kory J Lavine; Yuji Mishina; Chu-Xia Deng; David M Ornitz; Kyunghee Choi
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation.
Development (Cambridge, England) 2006;133(17):3473-84.
2006: Anne L Jacob; Craig Smith; Juha Partanen; David M Ornitz
Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation.
Developmental biology 2006;296(2):315-28.
2006: Grigoriy Gutin; Marie Fernandes; Laura Palazzolo; Hunki Paek; Kai Yu; David M Ornitz; Susan K McConnell; Jean Hebert
FGF signalling generates ventral telencephalic cells independently of SHH.
Development (Cambridge, England) 2006;133(15):2937-46.
2006: Chad A Perlyn; Gillian M Morriss-Kay; Tron A Darvann; Marissa Tenenbaum; David M Ornitz
A model for the pharmacological treatment of crouzon syndrome.
Neurosurgery 2006;59(1):210-5; discussion 210-5.
2006: Kory J Lavine; Andrew C White; Changwon Park; Craig S Smith; Kyunghee Choi; Fanxin Long; Chi-chung Hui; David M Ornitz
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.
Genes & development 2006;20(12):1651-66.
2006: Xiuqin Zhang; Omar A Ibrahimi; Shaun K Olsen; Hisashi Umemori; Moosa Mohammadi; David M Ornitz
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry 2006;281(23):15694-700.
2006: Inna Hughes; Isolde Thalmann; Ruediger Thalmann; David M Ornitz
Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development.
Brain research 2006;1091(1):58-74.
2006: Isolde Thalmann; Inna Hughes; Benton D Tong; David M Ornitz; Ruediger Thalmann
Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti.
Electrophoresis 2006;27(8):1598-608.
2006: Andrew C White; Jingsong Xu; Yongjun Yin; Craig Smith; Gregory Schmid; David M Ornitz
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.
Development (Cambridge, England) 2006;133(8):1507-17.
2006: Lynda M McDowell; Beth A Frazier; Daniel R Studelska; Kari Giljum; Jinghua Chen; Jian Liu; Kai Yu; David M Ornitz; Lijuan Zhang
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry 2006;281(11):6924-30.
2006: Xiuqin Zhang; Thaddeus S Stappenbeck; Andrew C White; Kory J Lavine; Jeffrey I Gordon; David M Ornitz
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development.
Development (Cambridge, England) 2006;133(1):173-80.
2005: Jun-Yang Lou; Fernanda Laezza; Benjamin R Gerber; Maolei Xiao; Kathryn A Yamada; Hali Hartmann; Ann Marie Craig; Jeanne M Nerbonne; David M Ornitz
Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels.
The Journal of physiology 2005;569(Pt 1):179-93.
2005: Xijie Yu; Omar A Ibrahimi; Regina Goetz; Fuming Zhang; Siobhan I Davis; Holly J Garringer; Robert J Linhardt; David M Ornitz; Moosa Mohammadi; Kenneth E White
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.
Endocrinology 2005;146(11):4647-56.
2005: Yingli Wang; Ran Xiao; Fan Yang; Baktiar O Karim; Anthony J Iacovelli; Juanliang Cai; Charles P Lerner; Joan T Richtsmeier; Jen M Leszl; Cheryl A Hill; Kai Yu; David M Ornitz; Jennifer H Elisseeff; David L Huso; Ethylin Jabs
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.
Development (Cambridge, England) 2005;132(15):3537-48.
2005: Claudia M Garcia; Kai Yu; Haotian Zhao; Ruth Ashery-Padan; David M Ornitz; Michael L Robinson; David C Beebe
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;233(2):516-27.
2005: David M Ornitz
FGF signaling in the developing endochondral skeleton.
Cytokine & growth factor reviews 2005;16(2):205-13.
2005: Kenneth E White; Jose M Cabral; Siobhan I Davis; Tonya Fishburn; Wayne E Evans; Shoji Ichikawa; Joanna Fields; Xijie Yu; Nick J Shaw; Neil J McLellan; Carole McKeown; David Fitzpatrick; Kai Yu; David M Ornitz; Michael J Econs
Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.
American journal of human genetics 2005;76(2):361-7.
2005: Kory J Lavine; Kai Yu; Andrew C White; Xiuqin Zhang; Craig Smith; Juha Partanen; David M Ornitz
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Developmental cell 2005;8(1):85-95.
2005: Hongliang Hu; Matthew J Hilton; Xiaolin Tu; Kai Yu; David M Ornitz; Fanxin Long
Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
Development (Cambridge, England) 2005;132(1):49-60.
2004: Inna Hughes; Brian Blasiole; David Huss; Mark E Warchol; Nigam P Rath; Belen Hurle; Elena G Ignatova; J David Dickman; Ruediger Thalmann; Robert Levenson; David M Ornitz
Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.
Developmental biology 2004;276(2):391-402.
2004: Nobuyuki Itoh; David M Ornitz
Evolution of the Fgf and Fgfr gene families.
Trends in genetics : TIG 2004;20(11):563-9.
2004: Ulla Pirvola; Xiuqin Zhang; Johanna Mantela; David M Ornitz; Jukka Ylikoski
Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions.
Developmental biology 2004;273(2):350-60.
2004: Elena G Ignatova; Isolde Thalmann; Baogang Xu; David M Ornitz; Ruediger Thalmann
Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice.
Hearing research 2004;194(1-2):65-72.
2004: Jennifer Schmahl; Yuna Kim; Jennifer S Colvin; David M Ornitz; Blanche Capel
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
Development (Cambridge, England) 2004;131(15):3627-36.
2004: Hisashi Umemori; Michael W Linhoff; David M Ornitz; Joshua R Sanes
FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Cell 2004;118(2):257-70.
2004: Liping Xiao; Takahiro Naganawa; Eneze Obugunde; Gloria A Gronowicz; David M Ornitz; J Douglas Coffin; Marja M Hurley
Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
The Journal of biological chemistry 2004;279(26):27743-52.
2004: Hua Long; Christelle Sabatier; Le Ma; Andrew S Plump; Wenlin Yuan; David M Ornitz; Atsushi Tamada; Fujio Murakami; Corey S Goodman; Marc Tessier-Lavigne
Conserved roles for Slit and Robo proteins in midline commissural axon guidance.
Neuron 2004;42(2):213-23.
2004: Peter Bialek; Britt Kern; xiangli yang; Marijke Schrock; Drazen Sosic; Nancy Hong; Hua Wu; Kai Yu; David M Ornitz; Eric N Olson; Monica J Justice; Gerard Karsenty
A twist code determines the onset of osteoblast differentiation.
Developmental cell 2004;6(3):423-35.
2004: Gladys Valverde-Franco; Hanlong Liu; David Davidson; Sen Chai; Hector Valderrama-Carvajal; David Goltzman; David M Ornitz; Janet E Henderson
Defective bone mineralization and osteopenia in young adult FGFR3-/- mice.
Human molecular genetics 2004;13(3):271-84.
2004: Norio Amizuka; David Davidson; Hanlong Liu; Gladys Valverde-Franco; Sen Chai; Takeyasu Maeda; Hidehiro Ozawa; Vicki Hammond; David M Ornitz; David Goltzman; Janet E Henderson
Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.
Bone 2004;34(1):13-25.
2003: Shaun K Olsen; Meirav Garbi; Niccolò Zampieri; Anna V Eliseenkova; David M Ornitz; mitchell goldfarb; Moosa Mohammadi
Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
The Journal of biological chemistry 2003;278(36):34226-36.
2003: Kai Yu; Jingsong Xu; Zhonghao Liu; Drazen Sosic; Jiansu Shao; Eric N Olson; Dwight A Towler; David M Ornitz
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth.
Development (Cambridge, England) 2003;130(13):3063-74.
2003: Wenlin Yuan; Yi Rao; Randal P Babiuk; John J Greer; Jane Y Wu; David M Ornitz
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5217-22.
2003: Belen Hurle; Elena G Ignatova; Silvia M Massironi; Tomoji Mashimo; Xavier Rios; Isolde Thalmann; Ruediger Thalmann; David M Ornitz
Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.
Human molecular genetics 2003;12(7):777-89.
2003: Luke Y S Oh; Adam Denninger; Jennifer S Colvin; Aditee Vyas; Shubha Tole; David M Ornitz; Rashmi Bansal
Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(3):883-94.
2003: Drazen Šošić; James A Richardson; Kai Yu; David M Ornitz; Eric N Olson
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.
Cell 2003;112(2):169-80.
2003: Nigel Pringle; Wei-ping Yu; Marisa Howell; Jennifer S Colvin; David M Ornitz; William D Richardson
Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains.
Development (Cambridge, England) 2003;130(1):93-102.
2002: David M Willis; Arleen P Loewy; Nichole Charlton-Kachigian; Jian-Su Shao; David M Ornitz; Dwight A Towler
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.
The Journal of biological chemistry 2002;277(40):37280-91.
2002: Eleonora Minina; Conny Kreschel; Michael Naski; David M Ornitz; Andrea Vortkamp
Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.
Developmental cell 2002;3(3):439-49.
2002: Qing Wang; Mark E Bardgett; Michael Wong; David F Wozniak; Junyang Lou; Benjamin D McNeil; Chen Chen; Anthony Nardi; David C Reid; Kelvin Yamada; David M Ornitz
Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14.
Neuron 2002;35(1):25-38.
2002: David M Ornitz; Pierre J Marie
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.
Genes & development 2002;16(12):1446-65.
2002: Zhonghao Liu; Jingsong Xu; Jennifer S Colvin; David M Ornitz
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.
Genes & development 2002;16(7):859-69.
2001: Shulei Zhao; Fang-Cheng Hung; J S Colvin; A White; W Dai; Frank J Lovicu; David M Ornitz; Paul A Overbeek
Patterning the optic neuroepithelium by FGF signaling and Ras activation.
Development (Cambridge, England) 2001;128(24):5051-60.
2001: Ruediger Thalmann; Elena G Ignatova; Anne E White-Olson; David M Ornitz; Isolde Thalmann
Development and maintenance of otoconia: biochemical considerations.
Annals of the New York Academy of Sciences 2001;942():162-78.
2001: Belen Hurle; K Lane; J Kenney; Lisa Tarantino; Maja Bucan; B H Brownstein; David M Ornitz
Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.
Genomics 2001;77(3):189-99.
2001: Q Wang; RP Green; G Zhao; David M Ornitz
Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains.
Development (Cambridge, England) 2001;128(19):3867-76.
2001: Omar A Ibrahimi; Anna V Eliseenkova; Alexander N Plotnikov; K Yu; David M Ornitz; Moosa Mohammadi
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7182-7.
2001: Jennifer S Colvin; Andrew C White; S J Pratt; David M Ornitz
Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme.
Development (Cambridge, England) 2001;128(11):2095-106.
2001: Kai Yu; David M Ornitz
Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3641-3.
2001: Jennifer S Colvin; RP Green; Jennifer Schmahl; Blanche Capel; David M Ornitz
Male-to-female sex reversal in mice lacking fibroblast growth factor 9.
Cell 2001;104(6):875-89.
2001: David M Ornitz
Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3.
Novartis Foundation symposium 2001;232():63-76; discussion 76-80, 272-82.
2001: David M Ornitz; N Itoh
Fibroblast growth factors.
Genome biology 2001;2(3):REVIEWS3005.
2000: Lisa Tarantino; Leonard Feiner; A Alavizadeh; Timothy Wiltshire; Belen Hurle; David M Ornitz; AL Webber; Jonathan A Raper; Andreas Lengeling; L B Rowe; Maja Bucan
A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.
Genomics 2000;66(1):55-64.
2000: Jingsong Xu; Zhonghao Liu; David M Ornitz
Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures.
Development (Cambridge, England) 2000;127(9):1833-43.
2000: David M Ornitz
FGFs, heparan sulfate and FGFRs: complex interactions essential for development.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(2):108-12.
2000: Q Wang; Donald McEwen; David M Ornitz
Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14.
Mechanisms of development 2000;90(2):283-7.
2000: Janet E Henderson; Michael Naski; Michelle M Aarts; D Wang; L Cheng; David Goltzman; David M Ornitz
Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):155-65.
1999: A Chellaiah; W Yuan; Meenakshi A Chellaiah; David M Ornitz
Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.
The Journal of biological chemistry 1999;274(49):34785-94.
1999: Donald McEwen; RP Green; Michael Naski; D A Towler; David M Ornitz
Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3',5'-monophosphate. Identification of a chondrocytic regulatory element.
The Journal of biological chemistry 1999;274(43):30934-42.
1999: Jennifer S Colvin; B Feldman; J H Nadeau; mitchell goldfarb; David M Ornitz
Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;216(1):72-88.
1999: W Yuan; L Zhou; J H Chen; J Y Wu; Y Rao; David M Ornitz
The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.
Developmental biology 1999;212(2):290-306.
1999: Y Wang; Isolde Thalmann; Ruediger Thalmann; David M Ornitz
Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15.
Genomics 1999;58(2):214-5.
1999: H C Ying; B Hurlé; Y Wang; Barbara A Bohne; M K Wuerffel; David M Ornitz
High-resolution mapping of tlt, a mouse mutant lacking otoconia.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(6):544-8.
1999: Jingsong Xu; A Lawshe; C A MacArthur; David M Ornitz
Genomic structure, mapping, activity and expression of fibroblast growth factor 17.
Mechanisms of development 1999;83(1-2):165-78.
1999: H S Li; J H Chen; W Wu; T Fagaly; L Zhou; W Yuan; S Dupuis; Z H Jiang; W Nash; C Gick; David M Ornitz; Jane Y Wu; Yi Rao
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.
Cell 1999;96(6):807-18.
1998: Y Wang; P E Kowalski; Isolde Thalmann; David M Ornitz; Dixie L Mager; Ruediger Thalmann
Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15345-50.
1998: Michael Naski; Jennifer S Colvin; J D Coffin; David M Ornitz
Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3.
Development (Cambridge, England) 1998;125(24):4977-88.
1998: David M Ornitz; Barbara A Bohne; Isolde Thalmann; Gary W Harding; Ruediger Thalmann
Otoconial agenesis in tilted mutant mice.
Hearing research 1998;122(1-2):60-70.
1998: Donald McEwen; David M Ornitz
Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors.
The Journal of biological chemistry 1998;273(9):5349-57.
1998: Xiaoling Xu; M Weinstein; Cuiling Li; Michael Naski; R I Cohen; David M Ornitz; P Leder; Chuxia Deng
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.
Development (Cambridge, England) 1998;125(4):753-65.
1998: Michael Naski; David M Ornitz
FGF signaling in skeletal development.
Frontiers in bioscience : a journal and virtual library 1998;3():d781-94.
1997: Donald McEwen; David M Ornitz
Determination of fibroblast growth factor receptor expression in mouse, rat and human samples using a single primer pair.
BioTechniques 1997;22(6):1068-70.
1997: A G Blunt; A Lawshé; Michael L Cunningham; M L Seto; David M Ornitz; C A MacArthur
Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands.
The Journal of biological chemistry 1997;272(6):3733-8.
1996: David M Ornitz; J Xu; Jennifer S Colvin; Donald McEwen; C A MacArthur; François Coulier; G Gao; mitchell goldfarb
Receptor specificity of the fibroblast growth factor family.
The Journal of biological chemistry 1996;271(25):15292-7.
1996: Michael Naski; Q Wang; J Xu; David M Ornitz
Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia.
Nature genetics 1996;13(2):233-7.
1996: Jennifer S Colvin; Barbara A Bohne; Gary W Harding; Donald McEwen; David M Ornitz
Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.
Nature genetics 1996;12(4):390-7.
1996: Ganesh Venkataraman; V Sasisekharan; A B Herr; David M Ornitz; Gabriel Waksman; C L Cooney; Robert Langer; Ram Sasisekharan
Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):845-50.
1996: S Santos-Ocampo; Jennifer S Colvin; A Chellaiah; David M Ornitz
Expression and biological activity of mouse fibroblast growth factor-9.
The Journal of biological chemistry 1996;271(3):1726-31.
1995: C A MacArthur; A Lawshé; J Xu; S Santos-Ocampo; Markku Heikinheimo; A T Chellaiah; David M Ornitz
FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development.
Development (Cambridge, England) 1995;121(11):3603-13.
1995: David M Ornitz; A B Herr; M Nilsson; J Westman; C M Svahn; Gabriel Waksman
FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides.
Science (New York, N.Y.) 1995;268(5209):432-6.
1995: Nissim Benvenisty; David M Ornitz
BK1: an FGF-responsive central nervous system-derived cell line.
Growth factors (Chur, Switzerland) 1995;12(1):49-55.
1994: Chu-Xia Deng; Anthony Wynshaw-Boris; Michael M Shen; C Daugherty; David M Ornitz; Philip Leder
Murine FGFR-1 is required for early postimplantation growth and axial organization.
Genes & development 1994;8(24):3045-57.
1994: A T Chellaiah; Donald McEwen; S Werner; J Xu; David M Ornitz
Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1.
The Journal of biological chemistry 1994;269(15):11620-7.
1994: Michael M Shen; R C Skoda; Robert Cardiff; J Campos-Torres; Philip Leder; David M Ornitz
Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.
The EMBO journal 1994;13(6):1375-85.
1992: Nissim Benvenisty; David M Ornitz; G L Bennett; B G Sahagan; A Kuo; Robert Cardiff; Philip Leder
Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes.
Oncogene 1992;7(12):2399-405.
1992: David M Ornitz; Robert Cardiff; A Kuo; Philip Leder
Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants.
Journal of the National Cancer Institute 1992;84(11):887-92.
1992: David M Ornitz; A Yayon; John G Flanagan; C M Svahn; E Levi; Philip Leder
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.
Molecular and cellular biology 1992;12(1):240-7.
1991: A Yayon; Michael Klagsbrun; J D Esko; P Leder; David M Ornitz
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
Cell 1991;64(4):841-8.
1991: David M Ornitz; R W Moreadith; Philip Leder
Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):698-702.