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Varinder Aggarwal

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Chemicals & Drugs

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TOP 3
Jack L-Y Chen; Matthew J Hesse; Helen K Scott; Christine L Willis; Varinder K Aggarwal
Highly diastereo- and enantioselective allylboration of aldehydes using α-substituted allyl/crotyl pinacol boronic esters via in situ generated borinic esters.
Charlotte G Watson; Varinder K Aggarwal
Asymmetric synthesis of 1-heteroaryl-1-arylalkyl tertiary alcohols and 1-pyridyl-1-arylethanes by lithiation-borylation methodology.
Catherine J Fletcher; Katherine M P Wheelhouse; Varinder K Aggarwal
Stereoselective total synthesis of (+)-giganin and its C10 epimer by using late-stage lithiation-borylation methodology.

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2013: Jack L-Y Chen; Matthew J Hesse; Helen K Scott; Christine L Willis; Varinder K Aggarwal
Highly diastereo- and enantioselective allylboration of aldehydes using α-substituted allyl/crotyl pinacol boronic esters via in situ generated borinic esters.
Journal of the American Chemical Society 2013;135(14):5316-9.
2013: Charlotte G Watson; Varinder K Aggarwal
Asymmetric synthesis of 1-heteroaryl-1-arylalkyl tertiary alcohols and 1-pyridyl-1-arylethanes by lithiation-borylation methodology.
Organic letters 2013;15(6):1346-9.
2013: Catherine J Fletcher; Katherine M P Wheelhouse; Varinder K Aggarwal
Stereoselective total synthesis of (+)-giganin and its C10 epimer by using late-stage lithiation-borylation methodology.
Angewandte Chemie (International ed. in English) 2013;52(9):2503-6.
2012: Sven P Fritz; Eoghan M McGarrigle; Thomas H West; Varinder K Aggarwal
Diastereoselective synthesis of CF3-substituted, epoxide-fused heterocycles with β-(trifluoromethyl)vinylsulfonium salts.
Organic letters 2012;14(24):6370-3.
2012: Matthew J Hesse; Christine L Willis; Craig P Butts; Varinder K Aggarwal
Diastereodivergent synthesis of trisubstituted alkenes through protodeboronation of allylic boronic esters: application to the synthesis of the Californian red scale beetle pheromone.
Angewandte Chemie (International ed. in English) 2012;51(50):12444-8.
2012: Benjamin M Partridge; Alexander P Pulis; Matthew Burns; Laëtitia Chausset-Boissarie; Varinder K Aggarwal
Enantioselective synthesis and cross-coupling of tertiary propargylic boronic esters using lithiation-borylation of propargylic carbamates.
Angewandte Chemie (International ed. in English) 2012;51(47):11795-9.
2012: Varinder K Aggarwal; Liam T Ball; Simon Carobene; Rickki L Connelly; Matthew J Hesse; Benjamin M Partridge; Philippe Roth; Stephen P Thomas; Matthew P Webster
Application of the lithiation-borylation reaction to the rapid and enantioselective synthesis of the bisabolane family of sesquiterpenes.
Chemical communications (Cambridge, England) 2012;48(74):9230-2.
2012: Graeme Coulthard; William Erb; Varinder K Aggarwal
Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps.
Nature 2012;489(7415):278-81.
2012: Stefan Roesner; Varinder K Aggarwal
Organic chemistry: reactions at the end of a tether.
Nature 2012;487(7405):48-9.
2012: Alexander P Pulis; Varinder K Aggarwal
Synthesis of enantioenriched tertiary boronic esters from secondary allylic carbamates. Application to the synthesis of C30 botryococcene.
Journal of the American Chemical Society 2012;134(17):7570-4.
2012: Anna Robinson; Varinder K Aggarwal
Stereocontrolled asymmetric synthesis of syn-E-1,4-diol-2-enes using allyl boronates and its application in the total synthesis of solandelactone F.
Organic & biomolecular chemistry 2012;10(9):1795-801.
2011: Robin Larouche-Gauthier; Irantzu Couto; Catherine J Fletcher; Varinder K Aggarwal
Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters.
Chemical communications (Cambridge, England) 2011;47(47):12592-4.
2011: Helen K Scott; Varinder K Aggarwal
Highly enantioselective synthesis of tertiary boronic esters and their stereospecific conversion to other functional groups and quaternary stereocentres.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(47):13124-32.
2011: Stefan Roesner; Ravindra P Sonawane; Javier Mansilla Casatejada; Tim G Elford; Varinder K Aggarwal
Enantioselective syntheses of (+)-sertraline and (+)-indatraline using lithiation/borylation-protodeboronation methodology.
Organic letters 2011;13(21):5740-3.
2011: Robin Larouche-Gauthier; Tim G Elford; Varinder K Aggarwal
Ate complexes of secondary boronic esters as chiral organometallic-type nucleophiles for asymmetric synthesis.
Journal of the American Chemical Society 2011;133(42):16794-7.
2011: Tim G Elford; Stefan Nave; Ravindra P Sonawane; Varinder K Aggarwal
Total synthesis of (+)-erogorgiaene using lithiation-borylation methodology, and stereoselective synthesis of each of its diastereoisomers.
Journal of the American Chemical Society 2011;133(42):16798-801.
2011: Martin A Lowe; Mehrnoosh Ostovar; Andrew A Calabrese; C Chun Chen; Serena Ferrini; Francesco Fontana; Paul G Lawrence; Varinder K Aggarwal
Palladium-mediated annulation of vinyl aziridines with Michael acceptors: stereocontrolled synthesis of substituted pyrrolidines and its application in a formal synthesis of (-)-α-kainic acid.
Angewandte Chemie (International ed. in English) 2011;50(28):6370-4.
2011: Francesco Fontana; C Chun Chen; Varinder K Aggarwal
Palladium-catalyzed insertion of CO2 into vinylaziridines: new route to 5-vinyloxazolidinones.
Organic letters 2011;13(13):3454-7.
2011: Eoghan M McGarrigle; Muhammad Yar; Ludovic Favereau; Sven P Fritz; Varinder K Aggarwal
An efficient synthesis of imidazolinium salts using vinyl sulfonium salts.
Organic letters 2011;13(12):3060-3.
2011: Ravindra P Sonawane; Vishal Jheengut; Constantinos Rabalakos; Robin Larouche-Gauthier; Helen K Scott; Varinder K Aggarwal
Enantioselective construction of quaternary stereogenic centers from tertiary boronic esters: methodology and applications.
Angewandte Chemie (International ed. in English) 2011;50(16):3760-3.
2011: Varinder K Aggarwal; Michael Binanzer; M Carolina de Ceglie; Maddalena Gallanti; Ben W Glasspoole; Stephanie J F Kendrick; Ravindra P Sonawane; Ana Vázquez-Romero; Matthew P Webster
Asymmetric synthesis of tertiary and quaternary allyl- and crotylsilanes via the borylation of lithiated carbamates.
Organic letters 2011;13(6):1490-3.
2011: Viktor Bagutski; Tim G Elford; Varinder K Aggarwal
Synthesis of highly enantioenriched C-tertiary amines from boronic esters: application to the synthesis of igmesine.
Angewandte Chemie (International ed. in English) 2011;50(5):1080-3.
2011: Muhammad Yar; Matthew G Unthank; Eoghan M McGarrigle; Varinder K Aggarwal
Remote chiral induction in vinyl sulfonium salt-mediated ring expansion of hemiaminals into epoxide-fused azepines.
Chemistry, an Asian journal 2011;6(2):372-5.
2010: Stefan Nave; Ravindra P Sonawane; Tim G Elford; Varinder K Aggarwal
Protodeboronation of tertiary boronic esters: asymmetric synthesis of tertiary alkyl stereogenic centers.
Journal of the American Chemical Society 2010;132(48):17096-8.
2010: Anna Robinson; Varinder K Aggarwal
Asymmetric total synthesis of solandelactone E: stereocontrolled synthesis of the 2-ene-1,4-diol core through a lithiation-borylation-allylation sequence.
Angewandte Chemie (International ed. in English) 2010;49(37):6673-5.
2010: Abel Ros; Antonio Bermejo; Varinder K Aggarwal
Benzylic boron reagents behaving as allylic boron reagents towards aldehydes: a new asymmetric reaction leading to homoallylic alcohols with concomitant dearomatisation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(32):9741-5.
2010: Viktor Bagutski; Rosalind M French; Varinder K Aggarwal
Full chirality transfer in the conversion of secondary alcohols into tertiary boronic esters and alcohols using lithiation-borylation reactions.
Angewandte Chemie (International ed. in English) 2010;49(30):5142-5.
2010: Samantha L Riches; Chandreyee Saha; Noelia Fontán Filgueira; Emma Grange; Eoghan M McGarrigle; Varinder K Aggarwal
On the mechanism of ylide-mediated cyclopropanations: evidence for a proton-transfer step and its effect on stereoselectivity.
Journal of the American Chemical Society 2010;132(22):7626-30.
2010: Michael Binanzer; Guang Yu Fang; Varinder K Aggarwal
Asymmetric synthesis of allylsilanes by the borylation of lithiated carbamates: formal total synthesis of (-)-decarestrictine D.
Angewandte Chemie (International ed. in English) 2010;49(25):4264-8.
2010: Martin Althaus; Adeem Mahmood; José Ramón Suárez; Stephen P Thomas; Varinder K Aggarwal
Application of the lithiation-borylation reaction to the preparation of enantioenriched allylic boron reagents and subsequent in situ conversion into 1,2,4-trisubstituted homoallylic alcohols with complete control over all elements of stereochemistry.
Journal of the American Chemical Society 2010;132(11):4025-8.
2010: Ona Illa; Muhammad Arshad; Abel Ros; Eoghan M McGarrigle; Varinder K Aggarwal
Practical and highly selective sulfur ylide mediated asymmetric epoxidations and aziridinations using an inexpensive, readily available chiral sulfide. Applications to the synthesis of quinine and quinidine.
Journal of the American Chemical Society 2010;132(6):1828-30.
2010: Francesco Fontana; Gian Cesare Tron; Nekane Barbero; Serena Ferrini; Stephen P Thomas; Varinder K Aggarwal
Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinyl aziridines.
Chemical communications (Cambridge, England) 2010;46(2):267-9.
2009: Varinder K Aggarwal
Organic synthesis: New uses for old building blocks.
Nature chemistry 2009;1(6):433-4.
2009: Muhammad Yar; Eoghan M McGarrigle; Varinder K Aggarwal
Bromoethylsulfonium salt--a more effective annulation agent for the synthesis of 6- and 7-membered 1,4-heterocyclic compounds.
Organic letters 2009;11(2):257-60.
2009: Abel Ros; Varinder K Aggarwal
Complete stereoretention in the rhodium-catalyzed 1,2-addition of chiral secondary and tertiary alkyl potassium trifluoroborate salts to aldehydes.
Angewandte Chemie (International ed. in English) 2009;48(34):6289-92.
2009: Guillaume Dutheuil; Matthew P Webster; Paul A Worthington; Varinder K Aggarwal
Stereocontrolled synthesis of carbon chains bearing contiguous methyl groups by iterative boronic ester homologations: application to the total synthesis of (+)-faranal.
Angewandte Chemie (International ed. in English) 2009;48(34):6317-9.
2009: Stephen P Thomas; Rosalind M French; Vishal Jheengut; Varinder K Aggarwal
Homologation and alkylation of boronic esters and boranes by 1,2-metallate rearrangement of boronate complexes.
Chemical record (New York, N.Y.) 2009;9(1):24-39.
2009: Stephen P Thomas; Varinder K Aggarwal
Asymmetric hydroboration of 1,1-disubstituted alkenes.
Angewandte Chemie (International ed. in English) 2009;48(11):1896-8.
2009: Frank Schmidt; Florian Keller; Emeline VEDRENNE; Varinder K Aggarwal
Stereocontrolled synthesis of beta-amino alcohols from lithiated aziridines and boronic esters.
Angewandte Chemie (International ed. in English) 2009;48(6):1149-52.
2009: Emeline VEDRENNE; Olov A Wallner; Maxime Vitale; Frank Schmidt; Varinder K Aggarwal
Homologation of boronic esters with lithiated epoxides for the stereocontrolled synthesis of 1,2- and 1,3-diols and 1,2,4-triols.
Organic letters 2009;11(1):165-8.
2008: Markus Hansch; Ona Illa; Eoghan M McGarrigle; Varinder K Aggarwal
Synthesis and application of easily recyclable thiomorpholines for use in sulfur ylide mediated asymmetric epoxidation of aldehydes.
Chemistry, an Asian journal 2008;3(8-9):1657-63.
2008: Dean Howells; Raphaël Robiette; Guang Yu Fang; Luke S Knowles; Michael D Woodrow; Jeremy N Harvey; Varinder K Aggarwal
Reactions of silyl-stabilised sulfur ylides with organoboranes: enantioselectivity, mechanism, and understanding.
Organic & biomolecular chemistry 2008;6(7):1185-9.
2008: Matthew G Unthank; Bahareh Tavassoli; Varinder K Aggarwal
Epoxy-annulations by reactions of alpha-amido ketones with vinyl sulfonium salts. Reagent versus substrate control and kinetic resolution.
Organic letters 2008;10(7):1501-4.
2008: Jie Bi; Varinder K Aggarwal
Application of furyl-stabilized sulfur ylides to a concise synthesis of 8a-epi-swainsonine.
Chemical communications (Cambridge, England) 2008;(1):120-2.
2008: Iain Coldham; Jignesh J Patel; Sophie Raimbault; David T E Whittaker; Harry Adams; Guang Yu Fang; Varinder K Aggarwal
Asymmetric lithiation-substitution of amines involving rearrangement of borates.
Organic letters 2008;10(1):141-3.
2008: Muhammad Yar; Eoghan M McGarrigle; Varinder K Aggarwal
An annulation reaction for the synthesis of morpholines, thiomorpholines, and piperazines from beta-heteroatom amino compounds and vinyl sulfonium salts.
Angewandte Chemie (International ed. in English) 2008;47(20):3784-6.
2007: Raphaël Robiette; Varinder K Aggarwal; Jeremy N Harvey
Mechanism of the Morita-Baylis-Hillman reaction: a computational investigation.
Journal of the American Chemical Society 2007;129(50):15513-25.
2007: Eoghan M McGarrigle; Eddie L Myers; Ona Illa; Michael A Shaw; Samantha L Riches; Varinder K Aggarwal
Chalcogenides as organocatalysts.
Chemical reviews 2007;107(12):5841-83.
2007: Guang Yu Fang; Olov A Wallner; Nadia Di Blasio; Xavier Ginesta; Jeremy N Harvey; Varinder K Aggarwal
Asymmetric sulfur ylide reactions with boranes: scope and limitations, mechanism and understanding.
Journal of the American Chemical Society 2007;129(47):14632-9.
2007: Anders Palmelund; Eddie L Myers; Lik Ren Tai; Steve Tisserand; Craig P Butts; Varinder K Aggarwal
A new manifold for the Morita reaction: diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines.
Chemical communications (Cambridge, England) 2007;(40):4128-30.
2007: Christoforos G Kokotos; Varinder K Aggarwal
Aminals as substrates for sulfur ylides: a synthesis of functionalized aziridines and N-heterocycles.
Organic letters 2007;9(11):2099-102.
2007: Jake L Stymiest; Guillaume Dutheuil; Adeem Mahmood; Varinder K Aggarwal
Lithiated carbamates: chiral carbenoids for iterative homologation of boranes and boronic esters.
Angewandte Chemie (International ed. in English) 2007;46(39):7491-4.
2007: Eddie L Myers; Johannes G De Vries; Varinder K Aggarwal
Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: enantiocontrol and applications in synthesis.
Angewandte Chemie (International ed. in English) 2007;46(11):1893-6.
2007: Guang Yu Fang; Varinder K Aggarwal
Asymmetric synthesis of alpha-substituted allyl boranes and their application in the synthesis of iso-agatharesinol.
Angewandte Chemie (International ed. in English) 2007;46(3):359-62.
2006: Eddie L Myers; Craig P Butts; Varinder K Aggarwal
BF3.OEt2 and TMSOTf: A synergistic combination of Lewis acids.
Chemical communications (Cambridge, England) 2006;(42):4434-6.
2006: Matthew G Unthank; Nigel Hussain; Varinder K Aggarwal
The use of vinyl sulfonium salts in the stereocontrolled asymmetric synthesis of epoxide- and aziridine-fused heterocycles: application to the synthesis of (-)-balanol.
Angewandte Chemie (International ed. in English) 2006;45(42):7066-9.
2006: D Michael Badine; Christina Hebach; Varinder K Aggarwal
Readily synthesized chiral sulfides as reagents for asymmetric epoxidation.
Chemistry, an Asian journal 2006;1(3):438-44.
2006: Christoforos G Kokotos; Varinder K Aggarwal
Hemiaminals as substrates for sulfur ylides: direct asymmetric syntheses of functionalised pyrrolidines and piperidines.
Chemical communications (Cambridge, England) 2006;(20):2156-8.
2006: Maxime Vitale; Thomas Lecourt; Chris G Sheldon; Varinder K Aggarwal
Ligand-induced control of C-H versus aliphatic C-C migration reactions of Rh carbenoids.
Journal of the American Chemical Society 2006;128(8):2524-5.
2006: Raphaël Robiette; Jeffery Richardson; Varinder K Aggarwal; Jeremy N Harvey
Reactivity and selectivity in the Wittig reaction: a computational study.
Journal of the American Chemical Society 2006;128(7):2394-409.
2006: Raphaël Robiette; Matteo Conza; Varinder K Aggarwal
Delineation of the factors governing reactivity and selectivity in epoxide formation from ammonium ylides and aldehydes.
Organic & biomolecular chemistry 2006;4(4):621-3.
2006: Raphaël Robiette; Guang Yu Fang; Jeremy N Harvey; Varinder K Aggarwal
Is phenyl a good migrating group in the rearrangement of organoborates generated from sulfur ylides?
Chemical communications (Cambridge, England) 2006;(7):741-3.
2006: Varinder K Aggarwal; Jonathan P H Charmant; Daniel Fuentes; Jeremy N Harvey; George Hynd; Diasuke Ohara; Willy Picoul; Raphaël Robiette; Catherine Smith; Jean-Luc Vasse; Caroline L Winn
Highly enantioselective synthesis of glycidic amides using camphor-derived sulfonium salts. Mechanism and applications in synthesis.
Journal of the American Chemical Society 2006;128(6):2105-14.
2005: Varinder K Aggarwal; Emma Grange
Asymmetric sulfonium ylide mediated cyclopropanation: stereocontrolled synthesis of (+)-LY354740.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;12(2):568-75.
2005: Raphaël Robiette; Jeffery Richardson; Varinder K Aggarwal; Jeremy N Harvey
On the origin of high E selectivity in the Wittig reaction of stabilized ylides: importance of dipole-dipole interactions.
Journal of the American Chemical Society 2005;127(39):13468-9.
2005: Varinder K Aggarwal; Jeremy N Harvey; Raphaël Robiette
On the importance of leaving group ability in reactions of ammonium, oxonium, phosphonium, and sulfonium ylides.
Angewandte Chemie (International ed. in English) 2005;44(34):5468-71.
2005: Varinder K Aggarwal; Berit Olofsson
Enantioselective alpha-arylation of cyclohexanones with diaryl iodonium salts: application to the synthesis of (-)-epibatidine.
Angewandte Chemie (International ed. in English) 2005;44(34):5516-9.
2005: Varinder K Aggarwal; Guang Yu Fang
Highly regioselective and diastereoselective epoxidation of allylic amines with Oxone.
Chemical communications (Cambridge, England) 2005;(27):3448-50.
2005: Varinder K Aggarwal; Amaury Patin; Steve Tisserand
Highly diastereoselective Diels-Alder reactions of Baylis-Hillman adducts.
Organic letters 2005;7(13):2555-7.
2005: Varinder K Aggarwal; Christina Hebach
Carboxylate-stabilised sulfur ylides (thetin salts) in asymmetric epoxidation for the synthesis of glycidic acids. Mechanism and implications.
Organic & biomolecular chemistry 2005;3(8):1419-27.
2005: Varinder K Aggarwal; Sarah Y Fulford; Guy C Lloyd-Jones
Reevaluation of the mechanism of the Baylis-Hillman reaction: implications for asymmetric catalysis.
Angewandte Chemie (International ed. in English) 2005;44(11):1706-8.
2005: Varinder K Aggarwal; Guang Yu Fang; Andreas T Schmidt
Synthesis and applications of chiral organoboranes generated from sulfonium ylides.
Journal of the American Chemical Society 2005;127(6):1642-3.
2005: Varinder K Aggarwal; Jie Bi
Reagent controlled addition of chiral sulfur ylides to chiral aldehydes.
Beilstein journal of organic chemistry 2005;1(1):4.
2004: Varinder K Aggarwal; Caroline L Winn
Catalytic, asymmetric sulfur ylide-mediated epoxidation of carbonyl compounds: scope, selectivity, and applications in synthesis.
Accounts of chemical research 2004;37(8):611-20.
2004: Varinder K Aggarwal; Christopher J Astle; Mark Rogers-Evans
A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis.
Organic letters 2004;6(9):1469-71.
2004: Varinder K Aggarwal; Jonathan P H Charmant; Leo Dudin; Marina Porcelloni; Jeffery Richardson
Effect of sulfide structure on enantioselectivity in catalytic asymmetric epoxidation of aldehydes: mechanistic insights and implications.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5467-71.
2003: Varinder K Aggarwal; Andrew J Belfield
Catalytic asymmetric Nazarov reactions promoted by chiral Lewis acid complexes.
Organic letters 2003;5(26):5075-8.
2003: Luke A Adams; Varinder K Aggarwal; Roger V Bonnert; Bettina Bressel; Russell Cox; Jon Shepherd; Javier de Vicente; Magnus Walter; William G Whittingham; Caroline L Winn
Diastereoselective synthesis of cyclopropane amino acids using diazo compounds generated in situ.
The Journal of organic chemistry 2003;68(24):9433-40.
2003: Varinder K Aggarwal; Guang Yu Fang; Graham Meek
Highly diastereoselective Simmons-Smith cyclopropanation of allylic amines.
Organic letters 2003;5(23):4417-20.
2003: Varinder K Aggarwal; Jeffery Richardson
The complexity of catalysis: origins of enantio- and diastereocontrol in sulfur ylide mediated epoxidation reactions.
Chemical communications (Cambridge, England) 2003;(21):2644-51.
2003: Varinder K Aggarwal; Jean-Luc Vasse
Asymmetric sulfur ylide mediated aziridination: application in the synthesis of the side chain of taxol.
Organic letters 2003;5(21):3987-90.
2003: Varinder K Aggarwal; Emma Alonso; Imhyuck Bae; George Hynd; Kevin M Lydon; Mary J Palmer; Mamta Patel; Marina Porcelloni; Jeffery Richardson; Rachel A Stenson; John R Studley; Jean-Luc Vasse; Caroline L Winn
A new protocol for the in situ generation of aromatic, heteroaromatic, and unsaturated diazo compounds and its application in catalytic and asymmetric epoxidation of carbonyl compounds. Extensive studies to map out scope and limitations, and rationalization of diastereo- and enantioselectivities.
Journal of the American Chemical Society 2003;125(36):10926-40.
2003: Varinder K Aggarwal; Imhyuck Bae; Hee-Yoon Lee; Jeffery Richardson; David T Williams
Sulfur-ylide-mediated synthesis of functionalized and trisubstituted epoxides with high enantioselectivity; application to the synthesis of CDP-840.
Angewandte Chemie (International ed. in English) 2003;42(28):3274-8.
2003: Varinder K Aggarwal; Javier de Vicente; Roger V Bonnert
A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ.
The Journal of organic chemistry 2003;68(13):5381-3.
2003: Varinder K Aggarwal; Chrystel Lopin; Franck Sandrinelli
New insights in the mechanism of amine catalyzed epoxidation: dual role of protonated ammonium salts as both phase transfer catalysts and activators of oxone.
Journal of the American Chemical Society 2003;125(25):7596-601.
2003: Varinder K Aggarwal; Richard S Grainger; Gary K Newton; Peter L Spargo; Adrian Hobson; Harry Adams
Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton.
Organic & biomolecular chemistry 2003;1(11):1884-93.
2003: Varinder K Aggarwal; J Robin Fulton; Chris G Sheldon; Javier de Vicente
Generation of phosphoranes derived from phosphites. A new class of phosphorus ylides leading to high E selectivity with semi-stabilizing groups in Wittig olefinations.
Journal of the American Chemical Society 2003;125(20):6034-5.
2003: Varinder K Aggarwal; Rebecca M Steele; Ritmaleni Ritmaleni; Juliet K Barrell; Ian Grayson
Highly enantioselective oxidations of ketene dithioacetals leading to trans bis-sulfoxides.
The Journal of organic chemistry 2003;68(10):4087-90.
2003: Varinder K Aggarwal; Guang Yu Fang; Jonathan P H Charmant; Graham Meek
Tandem formation and [2,3] rearrangement of methylene ammonium ylides derived from amines and the Simmons-Smith reagent.
Organic letters 2003;5(10):1757-60.
2003: Varinder K Aggarwal; Mike Butters; Paul W Davies
Palladium catalysed cyclisation-carbonylation of enynes to give cyclic gamma,delta-unsaturated acids.
Chemical communications (Cambridge, England) 2003;(9):1046-7.
2003: Varinder K Aggarwal; Stephen J Roseblade; Rikki Alexander
The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid.
Organic & biomolecular chemistry 2003;1(4):684-91.
2003: Varinder K Aggarwal; Ingo Emme; Sarah Y Fulford
Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope.
The Journal of organic chemistry 2003;68(3):692-700.
2002: Varinder K Aggarwal; Blanca N Esquivel-Zamora
Application of the chiral acyl anion equivalent, trans-1,3-dithiane 1,3-dioxide, to an asymmetric synthesis of (R)-salbutamol.
The Journal of organic chemistry 2002;67(24):8618-21.
2002: Varinder K Aggarwal; Chris G Sheldon; Gregor J Macdonald; William P Martin
A new method for the preparation of silyl enol ethers from carbonyl compounds and (trimethylsilyl)diazomethane in a regiospecific and highly stereoselective manner.
Journal of the American Chemical Society 2002;124(35):10300-1.
2002: Varinder K Aggarwal; George Hynd; Willy Picoul; Jean-Luc Vasse
Highly enantioselective darzens reaction of a camphor-derived sulfonium amide to give glycidic amides and their applications in synthesis.
Journal of the American Chemical Society 2002;124(34):9964-5.
2002: Varinder K Aggarwal; Ingo Emme; Andrea Mereu
Unexpected side reactions of imidazolium-based ionic liquids in the base-catalysed Baylis-Hillman reaction.
Chemical communications (Cambridge, England) 2002;(15):1612-3.
2002: Varinder K Aggarwal; Mamta Patel; John Studley
Synthesis of epoxides from aldehydes and tosylhydrazone salts catalysed by triphenylarsine: complete trans selectivity for all combinations of coupling partners.
Chemical communications (Cambridge, England) 2002;(14):1514-5.
2002: Varinder K Aggarwal; Jeremy N Harvey; Jeffery Richardson
Unraveling the mechanism of epoxide formation from sulfur ylides and aldehydes.
Journal of the American Chemical Society 2002;124(20):5747-56.
2002: Varinder K Aggarwal; Paul W Davies; William O Moss
A palladium catalysed cyclisation-carbonylation of bromodienes: control in carbonylation over facile beta-hydride elimination.
Chemical communications (Cambridge, England) 2002;(9):972-3.
2002: Varinder K Aggarwal; Emma Alonso; Marco Ferrara; Sharon E Spey
Highly diastereoselective aziridination of imines with trimethylsilyldiazomethane. Subsequent silyl substitution with electrophiles, ring opening, and metalation of C-silylaziridines--a cornucopia of highly selective transformations.
The Journal of organic chemistry 2002;67(7):2335-44.
2002: Varinder K Aggarwal; Stephen J Roseblade; Juliet K Barrell; Rikki Alexander
Highly diastereoselective nitrone cycloaddition onto a chiral ketene equivalent: asymmetric synthesis of cispentacin.
Organic letters 2002;4(7):1227-9.
2002: Varinder K Aggarwal; David K Dean; Andrea Mereu; Richard Williams
Rate acceleration of the Baylis-Hillman reaction in polar solvents (water and formamide). Dominant role of hydrogen bonding, not hydrophobic effects, is implicated.
The Journal of organic chemistry 2002;67(2):510-4.
2001: Varinder K Aggarwal; Javier de Vicente; Roger V Bonnert
Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines.
Organic letters 2001;3(17):2785-8.