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Brian O'Rourke

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Connie Chang; Takahiro Higuchi; Xiaoping Lin; Brian O'Rourke; Martin G Pomper; Andrew Rittenbach; Dongdong Sun; John V Terrovitis; Benjamin M W Tsui; Styliani Vakrou; Richard Wahl; Kirubel Woldemichael; Junaid M Afzal; Angel Chan; M Roselle Abraham
Cellular bioenergetics is an important determinant of the molecular imaging signal derived from luciferase and the sodium-iodide symporter.
Jackelyn M Kembro; Brian O'Rourke; Raimond L Winslow; Miguel A Aon; Sonia Cortassa
Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.
Carlo G Tocchetti; WALTER WATSON; Chaoqin Xie; Fadi G Akar; Viviane Caceres; Sonia Cortassa; Brian O'Rourke; Nazareno Paolocci; Sa Shi; Regina C Spadari-Bratfisch; Brian A Stanley; Miguel A Aon
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.

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2013: Connie Chang; Takahiro Higuchi; Xiaoping Lin; Brian O'Rourke; Martin G Pomper; Andrew Rittenbach; Dongdong Sun; John V Terrovitis; Benjamin M W Tsui; Styliani Vakrou; Richard Wahl; Kirubel Woldemichael; Junaid M Afzal; Angel Chan; M Roselle Abraham
Cellular bioenergetics is an important determinant of the molecular imaging signal derived from luciferase and the sodium-iodide symporter.
Circulation research 2013;112(3):441-50.
2013: Jackelyn M Kembro; Brian O'Rourke; Raimond L Winslow; Miguel A Aon; Sonia Cortassa
Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.
Biophysical journal 2013;104(2):332-43.
2012: Carlo G Tocchetti; WALTER WATSON; Chaoqin Xie; Fadi G Akar; Viviane Caceres; Sonia Cortassa; Brian O'Rourke; Nazareno Paolocci; Sa Shi; Regina C Spadari-Bratfisch; Brian A Stanley; Miguel A Aon
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Diabetes 2012;61(12):3094-105.
2012: Connie Y Chang; Jennifer H Elisseeff; Takahiro Higuchi; Xiaoping Lin; Hong-Chang Luo; Brian O'Rourke; CHARLES STEENBERGEN; Iossif A Strehin; Styliani Vakrou; Richard L Wahl; Theodore P Abraham; Patrick A Armstrong; Sophia N Brown; Angel T Chan; M Roselle Abraham
Hyaluronic acid-human blood hydrogels for stem cell transplantation.
Biomaterials 2012;33(32):8026-33.
2012: Darren Foster; Anders O Garlid; Keith D Garlid; Alice S Ho; Jasma Rucker; Agnieszka Sidor; Ling Chen; Brian O'Rourke
Mitochondrial ROMK channel is a molecular component of mitoK(ATP).
Circulation research 2012;111(4):446-54.
2012: Marvin G Chang; Enno de Lange; Alan Garfinkel; Hrayr S Karagueuzian; Eduardo Marban; Brian O'Rourke; Zhilin Qu; Leslie Tung; James N Weiss; Linmiao Xu; Connie Y Chang; ROSELLE ABRAHAM
Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers.
Biophysical journal 2012;102(12):2706-14.
2012: An-Chi Wei; Raimond L Winslow; Ting Liu; Brian O'Rourke
Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering.
The Journal of general physiology 2012;139(6):465-78.
2012: Miguel A Aon; Jackelyn Melissa Kembro; Brian O'Rourke; Nazareno Paolocci; Vidhya Sivakumaran; Brian Alan Stanley; Sonia Cortassa
Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study.
The Journal of general physiology 2012;139(6):479-91.
2012: Lufang Zhou; Brian O'Rourke
Cardiac mitochondrial network excitability: insights from computational analysis.
American journal of physiology. Heart and circulatory physiology 2012;302(11):H2178-89.
2012: Russell S Whelan; Ying Yang; John W Calvert; Yun Chen; Michael T Crow; Gerald W Dorn; Evripidis Gavathiotis; Saurabh Jha; Klitos Konstantinidis; Tullia Lindsten; Brian O'Rourke; Denis E Reyna; Craig B Thompson; An-Chi Wei; Richard N Kitsis
Bax regulates primary necrosis through mitochondrial dynamics.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6566-71.
2012: Andreas S Barth; Isotta Chimenti; Darryl R Davis; Gary Gerstenblith; Alice S Ho; Eddy Kizana; Taosheng Li; Brian O'Rourke; Rachel R Smith; Ioannis Terrovitis; Antonio C Wolff; Yiqiang Zhang; Eduardo Marban
Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab.
Stem cells translational medicine 2012;1(4):289-97.
2012: David Lloyd; Brian O'Rourke; Sonia Cortassa; Miguel A Aon
What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.
Integrative biology : quantitative biosciences from nano to macro 2012;4(1):65-74.
2011: Brian O'Rourke; Jennifer E Van Eyk; Darren Foster
Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.
Congestive heart failure (Greenwich, Conn.) 2011;17(6):269-82.
2011: Lufang Zhou; Miguel A Aon; Ting Liu; Brian O'Rourke
Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.
Journal of molecular and cellular cardiology 2011;51(5):632-9.
2011: Ying-bei Chen; Wen-Chih Cheng; Margaret Dayhoff-Brannigan; Kambiz Nassirpour Alavian; Miguel A Aon; Yi-Te Hsu; Elizabeth A Jonas; Leonard K Kaczmarek; Young H Ko; Hongmei Li; J Michael McCaffery; Brian O'Rourke; Peter L Pedersen; Fernando Pineda; Bing Qi; Lucian Soane; Xinchen Teng; Shifa Zou; J Marie Hardwick
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.
The Journal of cell biology 2011;195(2):263-76.
2011: Sheng-Bing Wang; Darren Foster; David A Kass; Brian O'Rourke; Jasma Rucker; Jennifer E Van Eyk
Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy.
Circulation research 2011;109(7):750-7.
2011: Peter M Abadir; Tyesha N Burks; Robert M Carey; Ronald D Cohn; CA Cooke; Michael T Crow; Neal S Fedarko; Darren Foster; Alka Jain; Brian O'Rourke; Jasma J Rucker; Barbara J Smith; Jeremy Walston
Identification and characterization of a functional mitochondrial angiotensin system.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14849-54.
2011: Fadi G Akar; Brian O'Rourke
Mitochondria are sources of metabolic sink and arrhythmias.
Pharmacology & therapeutics 2011;131(3):287-94.
2011: An-Chi Wei; Ting Liu; Sonia Cortassa; Raimond L Winslow; Brian O'Rourke
Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.
Biochimica et biophysica acta 2011;1813(7):1373-81.
2011: Raimond L Winslow; Sonia Cortassa; Yasmin L Hashambhoy; Brian O'Rourke; JJ Rice; Joseph L Greenstein
Integrative modeling of the cardiac ventricular myocyte.
Wiley interdisciplinary reviews. Systems biology and medicine 2011;3(4):392-413.
2011: An-Chi Wei; Raimond L Winslow; Miguel A Aon; Brian O'Rourke; Sonia Cortassa
Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach.
Biophysical journal 2011;100(12):2894-903.
2011: Michael Bonios; John Terrovitis; Connie Y Chang; James M Engles; Takahiro Higuchi; Riikka Lautamäki; Jianhua Yu; James Fox; Martin G Pomper; Richard L Wahl; Benjamin M W Tsui; Brian O'Rourke; Frank M Bengel; Eduardo Marban; ROSELLE ABRAHAM
Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2011;18(3):443-50.
2011: Brian O'Rourke
Public engagement in choosing health priorities.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2011;183(2):226-7.
2011: Melanie Y White; David A Brown; Simon Sheng; Robert N Cole; Brian O'Rourke; Jennifer E Van Eyk
Parallel proteomics to improve coverage and confidence in the partially annotated Oryctolagus cuniculus mitochondrial proteome.
Molecular & cellular proteomics : MCP 2011;10(2):M110.004291.
2011: Sonia Cortassa; Brian O'Rourke; Miguel A Aon; Raimond L Winslow
Metabolic control analysis applied to mitochondrial networks.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011;2011():4673-6.
2011: Anthony Cammarato; Christian H Ahrens; Nakissa N Alayari; Ermir Qeli; Jasma Rucker; Mary C Reedy; Christian M Zmasek; Marjan Gucek; Robert N Cole; Jennifer E Van Eyk; Rolf Bodmer; Brian O'Rourke; Sanford I Bernstein; Darren Foster
A mighty small heart: the cardiac proteome of adult Drosophila melanogaster.
PloS one 2011;6(4):e18497.
2010: Glenn I Fishman; Sumeet S Chugh; John P Dimarco; Christine M Albert; Mark E Anderson; Robert O Bonow; Alfred E Buxton; Peng-Sheng Chen; Mark Estes; Xavier Jouven; Raymond Kwong; David Austin Lathrop; Alice M Mascette; Jeanne M Nerbonne; Brian O'Rourke; Richard L Page; Dan Mark Roden; David S Rosenbaum; Nona Sotoodehnia; Natalia A Trayanova; Zhi-Jie Zheng
Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.
Circulation 2010;122(22):2335-48.
2010: Felix T Kurz; Miguel A Aon; Brian O'Rourke; Antonis A Armoundas
Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria.
American journal of physiology. Heart and circulatory physiology 2010;299(5):H1736-40.
2010: David A Brown; Brian O'Rourke
Cardiac mitochondria and arrhythmias.
Cardiovascular research 2010;88(2):241-9.
2010: Ting Liu; David A Brown; Brian O'Rourke
Role of mitochondrial dysfunction in cardiac glycoside toxicity.
Journal of molecular and cellular cardiology 2010;49(5):728-36.
2010: Alexander R Lyon; Paul J Joudrey; Dongzhu Jin; Robert D Nass; Miguel A Aon; Brian O'Rourke; Fadi G Akar
Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart.
Journal of molecular and cellular cardiology 2010;49(4):565-75.
2010: Felix T Kurz; Miguel A Aon; Brian O'Rourke; Antonis A Armoundas
Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14315-20.
2010: Samata M Kakkad; Meiyappan Solaiyappan; Brian O'Rourke; IOANNIS STASINOPOULOS; Ellen Ackerstaff; Venu Raman; Zaver M Bhujwalla; Kristine Glunde
Hypoxic tumor microenvironments reduce collagen I fiber density.
Neoplasia (New York, N.Y.) 2010;12(8):608-17.
2010: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Redox-optimized ROS balance: a unifying hypothesis.
Biochimica et biophysica acta 2010;1797(6-7):865-77.
2010: Michael Kohlhaas; Ting Liu; Andreas Knopp; Tanja Zeller; Mei Fang Ong; Michael Böhm; Brian O'Rourke; Christoph Maack
Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes.
Circulation 2010;121(14):1606-13.
2010: David A Brown; Miguel A Aon; Chad R Frasier; Ruben C Sloan; Andrew H Maloney; Ethan J Anderson; Brian O'Rourke
Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.
Journal of molecular and cellular cardiology 2010;48(4):673-9.
2010: Brian O'Rourke
Be still, my beating heart: never!
Circulation research 2010;106(2):238-9.
2010: Takeshi Aiba; Geoffrey G Hesketh; Ting Liu; Rachael Carlisle; Maria Celeste Villa-Abrille; Brian O'Rourke; Fadi G Akar; Gordon F Tomaselli
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.
Cardiovascular research 2010;85(3):454-63.
2010: Brian O'Rourke
From bioblasts to mitochondria: ever expanding roles of mitochondria in cell physiology.
Frontiers in physiology 2010;1():7.
2010: Lufang Zhou; Miguel A Aon; Tabish Almas; Sonia Cortassa; Raimond L Winslow; Brian O'Rourke
A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.
PLoS computational biology 2010;6(1):e1000657.
2010: Miguel A Aon; Sonia Cortassa; An-Chi Wei; Morten Grunnet; Brian O'Rourke
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.
Biochimica et biophysica acta 2010;1797(1):71-80.
2009: Lufang Zhou; Sonia Cortassa; An-Chi Wei; Miguel A Aon; Raimond L Winslow; Brian O'Rourke
Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.
Biophysical journal 2009;97(7):1843-52.
2009: Miguel A Aon; Sonia Cortassa; Fadi G Akar; David A Brown; L Zhou; Brian O'Rourke
From mitochondrial dynamics to arrhythmias.
The international journal of biochemistry & cell biology 2009;41(10):1940-8.
2009: Brian O'Rourke; Lothar A Blatter
Mitochondrial Ca2+ uptake: tortoise or hare?
Journal of molecular and cellular cardiology 2009;46(6):767-74.
2009: Sonia Cortassa; Brian O'Rourke; Raimond L Winslow; Miguel A Aon
Control and regulation of integrated mitochondrial function in metabolic and transport networks.
International journal of molecular sciences 2009;10(4):1500-13.
2009: Darren Foster; Jennifer E Van Eyk; Eduardo Marban; Brian O'Rourke
Redox signaling and protein phosphorylation in mitochondria: progress and prospects.
Journal of bioenergetics and biomembranes 2009;41(2):159-68.
2009: Ting Liu; Brian O'Rourke
Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart.
Journal of bioenergetics and biomembranes 2009;41(2):127-32.
2009: Sonia Cortassa; Brian O'Rourke; Raimond L Winslow; Miguel A Aon
Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function.
Biophysical journal 2009;96(6):2466-78.
2009: Takeshi Aiba; Geoffrey G Hesketh; Andreas S Barth; Ting Liu; Samantapudi Daya; Khalid Chakir; Veronica Lea Dimaano; Theodore P Abraham; Brian O'Rourke; Fadi G Akar; David A Kass; Gordon F Tomaselli
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.
Circulation 2009;119(9):1220-30.
2009: Andreas Ohler; Jutta Weisser-Thomas; Valentino Piacentino; Steven R Houser; Gordon F Tomaselli; Brian O'Rourke
Two-photon laser scanning microscopy of the transverse-axial tubule system in ventricular cardiomyocytes from failing and non-failing human hearts.
Cardiology research and practice 2009;2009():802373.
2008: Manling Zhang; Norimichi Koitabashi; Takahiro Nagayama; Ryan Rambaran; Ning Feng; Eiki Takimoto; Trisha Koenke; Brian O'Rourke; Hunter C Champion; Michael T Crow; David A Kass
Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes.
Cellular signalling 2008;20(12):2231-6.
2008: MARTIN SLODZINSKI; Miguel A Aon; Brian O'Rourke
Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.
Journal of molecular and cellular cardiology 2008;45(5):650-60.
2008: Darren Foster; Brian O'Rourke; Jennifer E Van Eyk
What can mitochondrial proteomics tell us about cardioprotection afforded by preconditioning?
Expert review of proteomics 2008;5(5):633-6.
2008: Gernot Plank; Lufang Zhou; Joseph L Greenstein; Sonia Cortassa; Raimond L Winslow; Brian O'Rourke; Natalia Trayanova
From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2008;366(1879):3381-409.
2008: Ting Liu; Brian O'Rourke
Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching.
Circulation research 2008;103(3):279-88.
2008: David A Brown; Miguel A Aon; Fadi G Akar; Ting Liu; Nicolas Sorarrain; Brian O'Rourke
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.
Cardiovascular research 2008;79(1):141-9.
2008: María Celeste Villa-Abrille; Agnieszka Sidor; Brian O'Rourke
Insulin effects on cardiac Na+/Ca2+ exchanger activity: role of the cytoplasmic regulatory loop.
The Journal of biological chemistry 2008;283(24):16505-13.
2008: Brian O'Rourke
The ins and outs of calcium in heart failure.
Circulation research 2008;102(11):1301-3.
2008: Miguel A Aon; Marc R Roussel; Sonia Cortassa; Brian O'Rourke; Douglas B Murray; Manfred Beckmann; David Lloyd
The scale-free dynamics of eukaryotic cells.
PloS one 2008;3(11):e3624.
2008: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Mitochondrial oscillations in physiology and pathophysiology.
Advances in experimental medicine and biology 2008;641():98-117.
2007: Christoph Maack; Brian O'Rourke
Excitation-contraction coupling and mitochondrial energetics.
Basic research in cardiology 2007;102(5):369-92.
2007: Katey M Lemar; Miguel A Aon; Sonia Cortassa; Brian O'Rourke; Carsten T Müller; David Lloyd
Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy.
Yeast (Chichester, England) 2007;24(8):695-706.
2007: Miguel A Aon; Sonia Cortassa; Christoph Maack; Brian O'Rourke
Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.
The Journal of biological chemistry 2007;282(30):21889-900.
2007: Antonis A Armoundas; Jochen Rose; Rajesh Aggarwal; Bruno D Stuyvers; Brian O'Rourke; David A Kass; Eduardo Marban; Stephen R Shorofsky; Gordon F Tomaselli; C William Balke
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.
American journal of physiology. Heart and circulatory physiology 2007;292(3):H1607-18.
2007: Carlo G Tocchetti; Wang Wang; Jeffrey P Froehlich; Sabine Huke; Miguel A Aon; Gerald M Wilson; Giulietta Di Benedetto; Brian O'Rourke; Wei Dong Gao; David A Wink; John P Toscano; Manuela Zaccolo; Donald M Bers; Hector H Valdivia; Heping Cheng; David A Kass; Nazareno Paolocci
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circulation research 2007;100(1):96-104.
2007: Brian O'Rourke; Sonia Cortassa; Fadi G Akar; Miguel A Aon
Mitochondrial ion channels in cardiac function and dysfunction.
Novartis Foundation symposium 2007;287():140-51; discussion 152-6.
2007: Brian O'Rourke
Mitochondrial ion channels.
Annual review of physiology 2007;69():19-49.
2006: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
The fundamental organization of cardiac mitochondria as a network of coupled oscillators.
Biophysical journal 2006;91(11):4317-27.
2006: Sonia Cortassa; Miguel A Aon; Brian O'Rourke; Robert Jacques; Hsiang-Jer Tseng; Eduardo Marban; Raimond L Winslow
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.
Biophysical journal 2006;91(4):1564-89.
2006: Christoph Maack; Sonia Cortassa; Miguel A Aon; Anand Ganesan; Ting Liu; Brian O'Rourke
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes.
Circulation research 2006;99(2):172-82.
2006: Anand Ganesan; Christoph Maack; David C Johns; Agnieszka Sidor; Brian O'Rourke
Beta-adrenergic stimulation of L-type Ca2+ channels in cardiac myocytes requires the distal carboxyl terminus of alpha1C but not serine 1928.
Circulation research 2006;98(2):e11-8.
2006: Miguel A Aon; Sonia Cortassa; Fadi G Akar; Brian O'Rourke
Mitochondrial criticality: a new concept at the turning point of life or death.
Biochimica et biophysica acta 2006;1762(2):232-40.
2005: Fadi G Akar; Miguel A Aon; Gordon F Tomaselli; Brian O'Rourke
The mitochondrial origin of postischemic arrhythmias.
The Journal of clinical investigation 2005;115(12):3527-35.
2005: Hossein Ardehali; Brian O'Rourke; Eduardo Marban
Cardioprotective role of the mitochondrial ATP-binding cassette protein 1.
Circulation research 2005;97(8):740-2.
2005: Katey M Lemar; Ourania Passa; Miguel A Aon; Sonia Cortassa; Carsten T Müller; Sue Plummer; Brian O'Rourke; David Lloyd
Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans.
Microbiology (Reading, England) 2005;151(Pt 10):3257-65.
2005: Brian O'Rourke; Sonia Cortassa; Miguel A Aon
Mitochondrial ion channels: gatekeepers of life and death.
Physiology (Bethesda, Md.) 2005;20():303-15.
2005: Hossein Ardehali; Brian O'Rourke
Mitochondrial K(ATP) channels in cell survival and death.
Journal of molecular and cellular cardiology 2005;39(1):7-16.
2005: Jochen Rose; Antonis A Armoundas; Yanli Tian; Deborah DiSilvestre; Miroslava Burysek; Victoria L Halperin; Brian O'Rourke; David A Kass; Eduardo Marban; Gordon F Tomaselli
Molecular correlates of altered expression of potassium currents in failing rabbit myocardium.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2077-87.
2005: Anand Ganesan; Brian O'Rourke; Christoph Maack; Henry M Colecraft; Agnieszka Sidor; David C Johns
Reverse engineering the L-type Ca2+ channel alpha1c subunit in adult cardiac myocytes using novel adenoviral vectors.
Biochemical and biophysical research communications 2005;329(2):749-54.
2005: Christoph Maack; Anand Ganesan; Agnieszka Sidor; Brian O'Rourke
Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites.
Circulation research 2005;96(1):91-9.
2005: Antti J Tanskanen; Joseph L Greenstein; Brian O'Rourke; Raimond L Winslow
The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.
Biophysical journal 2005;88(1):85-95.
2005: Kenji Matsushita; Munekazu Yamakuchi; Craig N Morrell; Michitaka Ozaki; Brian O'Rourke; Kaikobad Irani; Charles J Lowenstein
Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.
Blood 2005;105(1):207-14.
2004: Sonia Cortassa; Miguel A Aon; Raimond L Winslow; Brian O'Rourke
A mitochondrial oscillator dependent on reactive oxygen species.
Biophysical journal 2004;87(3):2060-73.
2004: Ion A Hobai; Christoph Maack; Brian O'Rourke
Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure.
Circulation research 2004;95(3):292-9.
2004: Carlo Di Mario; Huw Griffiths; Brian O'Rourke; Sam Kaddoura
The impact of Sirolimus Eluting stents in interventional cardiology.
International journal of cardiology 2004;95(2-3):117-21.
2004: Ion A Hobai; Brian O'Rourke
The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease.
Expert opinion on investigational drugs 2004;13(6):653-64.
2004: Miguel A Aon; Sonia Cortassa; Brian O'Rourke
Percolation and criticality in a mitochondrial network.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4447-52.
2004: Brian O'Rourke
Evidence for mitochondrial K+ channels and their role in cardioprotection.
Circulation research 2004;94(4):420-32.
2004: Miguel A Aon; Brian O'Rourke; Sonia Cortassa
The fractal architecture of cytoplasmic organization: scaling, kinetics and emergence in metabolic networks.
Molecular and cellular biochemistry 2004;256-257(1-2):169-84.
2003: Miguel A Aon; Sonia Cortassa; Eduardo Marban; Brian O'Rourke
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes.
The Journal of biological chemistry 2003;278(45):44735-44.
2003: Kenji Matsushita; Craig N Morrell; Beatrice Cambien; Shui Xiang Yang; Munekazu Yamakuchi; Clare Bao; Makoto R Hara; Richard A Quick; Wangsen Cao; Brian O'Rourke; John M Lowenstein; Jonathan Pevsner; Denisa D Wagner; Charles J Lowenstein
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.
Cell 2003;115(2):139-50.
2003: Antonis A Armoundas; Ion A Hobai; Gordon F Tomaselli; Raimond L Winslow; Brian O'Rourke
Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts.
Circulation research 2003;93(1):46-53.
2003: Sonia Cortassa; Miguel A Aon; Eduardo Marban; Raimond L Winslow; Brian O'Rourke
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics.
Biophysical journal 2003;84(4):2734-55.
2003: Norihito Sasaki; Mitsushige Murata; Yiru Guo; Su-Hyun Jo; Andreas Ohler; Masaharu Akao; Brian O'Rourke; Rui-Ping Xiao; Roberto Bolli; Eduardo Marban
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
Circulation 2003;107(8):1183-8.
2003: Masaharu Akao; Brian O'Rourke; Hideo Kusuoka; Yasushi Teshima; Steven P Jones; Eduardo Marban
Differential actions of cardioprotective agents on the mitochondrial death pathway.
Circulation research 2003;92(2):195-202.
2003: Masaharu Akao; Brian O'Rourke; Yasushi Teshima; Jegatheesan Seharaseyon; Eduardo Marban
Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes.
Circulation research 2003;92(2):186-94.
2003: Mark J Mason; Brian O'Rourke; Mahmoud Al-Bustami; Charles Ilsley
Differential response of coronary collateral channels to atrial pacing and balloon occlusion at angioplasty.
Coronary artery disease 2003;14(1):81-7.
2003: Shidong Li; Jonathon Simons; Nicholas Detorie; Brian O'Rourke; Ulrike M Hamper; Theodore L DeWeese
Dosimetric and technical considerations for interstitial adenoviral gene therapy as applied to prostate cancer.
International journal of radiation oncology, biology, physics 2003;55(1):204-14.
2002: Wenhong Xu; Yongge Liu; Sheng Wang; Todd McDonald; Jennifer E Van Eyk; Agnieszka Sidor; Brian O'Rourke
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane.
Science (New York, N.Y.) 2002;298(5595):1029-33.
2002: Zhenhui Chen; Carmen Alcayaga; Benjamin A Suarez-Isla; Brian O'Rourke; Gordon F Tomaselli; Eduardo Marban
A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore.
The Journal of biological chemistry 2002;277(27):24653-8.
2002: Lili A Barouch; Robert W Harrison; Michel W Skaf; Gisele O Rosas; Thomas P Cappola; Zoulficar A Kobeissi; Ion A Hobai; Christopher A Lemmon; Arthur L Burnett; Brian O'Rourke; E Rene Rodriguez; Paul L Huang; João A C Lima; Dan E Berkowitz; Joshua M Hare
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.
Nature 2002;416(6878):337-9.
2002: Shao-kui Wei; John F Quigley; Stephen U Hanlon; Brian O'Rourke; Mark C P Haigney
Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes.
Cardiovascular research 2002;53(2):334-40.
2001: Mitsushige Murata; Masaharu Akao; Brian O'Rourke; Eduardo Marban
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.
Circulation research 2001;89(10):891-8.
2001: Masaharu Akao; Andreas Ohler; Brian O'Rourke; Eduardo Marban
Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells.
Circulation research 2001;88(12):1267-75.
2001: Y Liu; Brian O'Rourke
Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?
Circulation research 2001;88(8):750-2.
2001: Norihito Sasaki; T Sato; Eduardo Marban; Brian O'Rourke
ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1882-8.
2001: Ion A Hobai; Brian O'Rourke
Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure.
Circulation 2001;103(11):1577-84.
2001: Yongge Liu; G Ren; Brian O'Rourke; Eduardo Marban; Jegatheesan Seharaseyon
Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.
Molecular pharmacology 2001;59(2):225-30.
2001: M Saleet Jafri; S J Dudycha; Brian O'Rourke
Cardiac energy metabolism: models of cellular respiration.
Annual review of biomedical engineering 2001;3():57-81.
2000: Brian O'Rourke
Pathophysiological and protective roles of mitochondrial ion channels.
The Journal of physiology 2000;529 Pt 1():23-36.
2000: Brian O'Rourke
Myocardial K(ATP) channels in preconditioning.
Circulation research 2000;87(10):845-55.
2000: Jegatheesan Seharaseyon; Andreas Ohler; Norihito Sasaki; H Fraser; T Sato; David C Johns; Brian O'Rourke; Eduardo Marban
Molecular composition of mitochondrial ATP-sensitive potassium channels probed by viral Kir gene transfer.
Journal of molecular and cellular cardiology 2000;32(11):1923-30.
2000: Ion A Hobai; Brian O'Rourke
Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure.
Circulation research 2000;87(8):690-8.
2000: T Sato; Norihito Sasaki; Brian O'Rourke; Eduardo Marban
Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: a key step in ischemic preconditioning?
Circulation 2000;102(7):800-5.
2000: Jegatheesan Seharaseyon; Norihito Sasaki; Andreas Ohler; T Sato; H Fraser; David C Johns; Brian O'Rourke; Eduardo Marban
Evidence against functional heteromultimerization of the KATP channel subunits Kir6.1 and Kir6.2.
The Journal of biological chemistry 2000;275(23):17561-5.
2000: T Sato; Norihito Sasaki; Jegatheesan Seharaseyon; Brian O'Rourke; Eduardo Marban
Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection.
Circulation 2000;101(20):2418-23.
2000: T Sato; Norihito Sasaki; Brian O'Rourke; Eduardo Marban
Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels.
Journal of the American College of Cardiology 2000;35(2):514-8.
2000: Norihito Sasaki; T Sato; Andreas Ohler; Brian O'Rourke; Eduardo Marban
Activation of mitochondrial ATP-dependent potassium channels by nitric oxide.
Circulation 2000;101(4):439-45.
1999: Brian O'Rourke
Apoptosis: rekindling the mitochondrial fire.
Circulation research 1999;85(10):880-3.
1999: Yongge Liu; T Sato; Jegatheesan Seharaseyon; A Szewczyk; Brian O'Rourke; Eduardo Marban
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.
Annals of the New York Academy of Sciences 1999;874():27-37.
1999: H Hu; T Sato; Jegatheesan Seharaseyon; Yongge Liu; David C Johns; Brian O'Rourke; Eduardo Marban
Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels.
Molecular pharmacology 1999;55(6):1000-5.
1999: UC Hoppe; David C Johns; Eduardo Marban; Brian O'Rourke
Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential.
Circulation research 1999;84(8):964-72.
1999: Raimond L Winslow; JJ Rice; S Jafri; Eduardo Marban; Brian O'Rourke
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.
Circulation research 1999;84(5):571-86.
1999: Brian O'Rourke; David A Kass; Gordon F Tomaselli; Stefan Kääb; Richard S Tunin; Eduardo Marban
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
Circulation research 1999;84(5):562-70.
1999: David C Johns; RUTH MARX-RATTNER; Richard E Mains; Brian O'Rourke; Eduardo Marban
Inducible genetic suppression of neuronal excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(5):1691-7.
1998: M J Lalli; David C Johns; M Janecki; Yongge Liu; Brian O'Rourke; Eduardo Marban
Suppression of KATP currents by gene transfer of a dominant negative Kir6.2 construct.
Pflügers Archiv : European journal of physiology 1998;436(6):957-61.
1998: T Sato; Brian O'Rourke; Eduardo Marban
Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.
Circulation research 1998;83(1):110-4.
1998: Yongge Liu; T Sato; Brian O'Rourke; Eduardo Marban
Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?
Circulation 1998;97(24):2463-9.
1998: D N Romashko; Eduardo Marban; Brian O'Rourke
Subcellular metabolic transients and mitochondrial redox waves in heart cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1618-23.
1997: Yongge Liu; Wei Dong Gao; Brian O'Rourke; Eduardo Marban
Priming effect of adenosine on K(ATP) currents in intact ventricular myocytes: implications for preconditioning.
The American journal of physiology 1997;273(4 Pt 2):H1637-43.
1997: Ronald G Victor; Frank Rusnak; Robert A Sikkink; Eduardo Marban; Brian O'Rourke
Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurin.
The Journal of membrane biology 1997;156(1):53-61.
1997: Gail D Thomas; Brian O'Rourke; Robert A Sikkink; Frank Rusnak; Eduardo Marban; Ronald G Victor
Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) versus phosphatases 1 and 2A.
Brain research 1997;749(1):101-8.
1996: Yongge Liu; Wei Dong Gao; Brian O'Rourke; Eduardo Marban
Cell-type specificity of preconditioning in an in vitro model.
Basic research in cardiology 1996;91(6):450-7.
1996: JH Lawrence; D W Orias; Jeffrey R Balser; H Bradley Nuss; Gordon F Tomaselli; Brian O'Rourke; Eduardo Marban
Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation.
Biophysical journal 1996;71(3):1285-94.
1996: Yongge Liu; Wei Dong Gao; Brian O'Rourke; Eduardo Marban
Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine. Implications for ischemic preconditioning.
Circulation research 1996;78(3):443-54.
1996: Stefan Kääb; H Bradley Nuss; Nipavan Chiamvimonvat; Brian O'Rourke; PH Pak; David A Kass; Eduardo Marban; Gordon F Tomaselli
Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure.
Circulation research 1996;78(2):262-73.
1995: Ronald G Victor; Gail D Thomas; Eduardo Marban; Brian O'Rourke
Presynaptic modulation of cortical synaptic activity by calcineurin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6269-73.
1995: Nipavan Chiamvimonvat; Brian O'Rourke; T J Kamp; R G Kallen; F Hofmann; V Flockerzi; Eduardo Marban
Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels.
Circulation research 1995;76(3):325-34.
1995: Brian O'Rourke; B M Ramza; D N Romashko; Eduardo Marban
Metabolic oscillations in heart cells.
Advances in experimental medicine and biology 1995;382():165-74.
1995: M D Ashen; Brian O'Rourke; K A Kluge; David C Johns; Gordon F Tomaselli
Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line.
The American journal of physiology 1995;268(1 Pt 2):H506-11.
1994: Brian O'Rourke; B M Ramza; Eduardo Marban
Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells.
Science (New York, N.Y.) 1994;265(5174):962-6.
1993: Brian O'Rourke
Ion channels as sensors of cellular energy. Mechanisms for modulation by magnesium and nucleotides.
Biochemical pharmacology 1993;46(7):1103-12.
1992: Brian O'Rourke; D K Reibel; Andrew P Thomas
Alpha-adrenergic modification of the Ca2+ transient and contraction in single rat cardiomyocytes.
Journal of molecular and cellular cardiology 1992;24(8):809-20.
1992: Brian O'Rourke; P H Backx; Eduardo Marban
Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes.
Science (New York, N.Y.) 1992;257(5067):245-8.
1992: Brian O'Rourke; D K Reibel
Effects of adrenoceptor blockade on cardiac hypertrophy and myocardial phospholipids.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(1):95-100.
1991: P H Backx; Brian O'Rourke; Eduardo Marban
Flash photolysis of magnesium-DM-nitrophen in heart cells. A novel approach to probe magnesium- and ATP-dependent regulation of calcium channels.
American journal of hypertension 1991;4(7 Pt 2):416S-421S.
1990: Brian O'Rourke; D K Reibel; Andrew P Thomas
High-speed digital imaging of cytosolic Ca2+ and contraction in single cardiomyocytes.
The American journal of physiology 1990;259(1 Pt 2):H230-42.
1987: D K Reibel; Brian O'Rourke; K A Foster
Mechanisms for altered carnitine content in hypertrophied rat hearts.
The American journal of physiology 1987;252(3 Pt 2):H561-5.
1986: D K Reibel; Brian O'Rourke; K A Foster; H Hutchinson; C E Uboh; R L Kent
Altered phospholipid metabolism in pressure-overload hypertrophied hearts.
The American journal of physiology 1986;250(1 Pt 2):H1-6.
1985: K A Foster; Brian O'Rourke; D K Reibel
Altered carnitine metabolism in spontaneously hypertensive rats.
The American journal of physiology 1985;249(2 Pt 1):E183-6.