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George Orphanides

Research Profile

Chemicals & Drugs

Anatomy

Devices

Oligonucleotide Array Sequence Analysis

Occupations

Toxicogenetics

Physiology

Living Beings

Mouse

Procedures

Gene Expression Profiling

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Publications

TOP 3
Andreas Schlicker; Susie Weston; Garry Beran; Denis Alferez Castro; Christine M Chresta; Sara Davenport; Tim French; Kerry Heathcote; Gael McWalter; George Orphanides; Alison Pritchard; Sarah Runswick; Lodewyk F A Wessels
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
Fei Ling Lim; Richard A Currie; George Orphanides; Jonathan G Moggs
Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review.
Guy Mainwaring; Fei Ling Lim; Kate Antrobus; Cindy Swain; Mike Clapp; Ian Kimber; George Orphanides; Jonathan G Moggs
Identification of early molecular pathways affected by paraquat in rat lung.

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All Publications

2012: Andreas Schlicker; Susie Weston; Garry Beran; Denis Alferez Castro; Christine M Chresta; Sara Davenport; Tim French; Kerry Heathcote; Gael McWalter; George Orphanides; Alison Pritchard; Sarah Runswick; Lodewyk F A Wessels
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC medical genomics 2012;5():66.
2006: Fei Ling Lim; Richard A Currie; George Orphanides; Jonathan G Moggs
Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(10-11):1140-51.
2006: Guy Mainwaring; Fei Ling Lim; Kate Antrobus; Cindy Swain; Mike Clapp; Ian Kimber; George Orphanides; Jonathan G Moggs
Identification of early molecular pathways affected by paraquat in rat lung.
Toxicology 2006;225(2-3):157-72.
2006: Ruth Stuckey; Tom Aldridge; Fei Ling Lim; David Moore; Helen Tinwell; Nicola Doherty; Reginald Davies; Andrew G Smith; Ian Kimber; John Ashby; George Orphanides; Jonathan G Moggs
Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.
Molecular and cellular endocrinology 2006;253(1-2):22-9.
2006: N Macdonald; Marie Cumberbatch; M Singh; Jonathan G Moggs; George Orphanides; R J Dearman; Christopher E M Griffiths; I Kimber
Proteomic analysis of suction blister fluid isolated from human skin.
Clinical and experimental dermatology 2006;31(3):445-8.
2006: Raffaella Corvi; Hans-Jürgen Ahr; Silvio Albertini; David Blakey; Libero Clerici; Sandra Coecke; George R Douglas; Laura Gribaldo; John P Groten; Bernd Haase; Karen Hamernik; Thomas Hartung; Tohru Inoue; Ian Indans; Daniela Maurici; George Orphanides; Diana Rembges; Susanna-Assunta Sansone; Jason R Snape; Eisaku Toda; Weida Tong; Joost H M van Delft; Brenda Weis; Leonard M Schechtman
Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.
Environmental health perspectives 2006;114(3):420-9.
2005: Neil Macdonald; Julie P I Welburn; Martin E M Noble; Anhco Nguyen; Michael B Yaffe; David Clynes; Jonathan G Moggs; George Orphanides; Stuart Thomson; John W Edmunds; Alison L Clayton; Jane A Endicott; Louis C Mahadevan
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
Molecular cell 2005;20(2):199-211.
2005: Richard A Currie; George Orphanides; Jonathan G Moggs
Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data.
Reproductive toxicology (Elmsford, N.Y.) 2005;20(3):433-40.
2005: Richard A Currie; Vincent Bombail; Jason D Oliver; David Moore; Fei Ling Lim; Victoria Gwilliam; Ian Kimber; Kevin Chipman; Jonathan G Moggs; George Orphanides
Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):453-69.
2005: Jonathan G Moggs; T C Murphy; Fei Ling Lim; David Moore; Ruth Stuckey; K Antrobus; Ian Kimber; George Orphanides
Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes.
Journal of molecular endocrinology 2005;34(2):535-51.
2004: Jonathan G Moggs; Helen Tinwell; Tracey Spurway; Hur-Song Chang; Ian Pate; Fei Ling Lim; David Moore; Anthony Soames; Ruth Stuckey; Richard Currie; Tong Zhu; Ian Kimber; John Ashby; George Orphanides
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Environmental health perspectives 2004;112(16):1589-606.
2004: Jonathan G Moggs; John Ashby; Helen Tinwell; Fei Ling Lim; David Moore; Ian Kimber; George Orphanides
The need to decide if all estrogens are intrinsically similar.
Environmental health perspectives 2004;112(11):1137-42.
2004: Jonathan G Moggs; George Orphanides
The role of chromatin in molecular mechanisms of toxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(2):218-24.
2004: Vincent Bombail; Jonathan G Moggs; George Orphanides
Perturbation of epigenetic status by toxicants.
Toxicology letters 2004;149(1-3):51-8.
2003: George Orphanides; Ian Kimber
Toxicogenetics: applications and opportunities.
Toxicological sciences : an official journal of the Society of Toxicology 2003;75(1):1-6.
2003: Rimma Belotserkovskaya; Sangtaek Oh; Vladimir Bondarenko; George Orphanides; Vasily M Studitsky; Danny Reinberg
FACT facilitates transcription-dependent nucleosome alteration.
Science (New York, N.Y.) 2003;301(5636):1090-3.
2003: Jonathan G Moggs; George Orphanides
Genomic analysis of stress response genes.
Toxicology letters 2003;140-141():149-53.
2003: George Orphanides
Toxicogenomics: challenges and opportunities.
Toxicology letters 2003;140-141():145-8.
2003: Catherine J Betts; Jonathan G Moggs; Helen T Caddick; Marie Cumberbatch; George Orphanides; Rebecca J Dearman; Cindy A Ryan; Ben C Hulette; G Frank Gerberick; Ian Kimber
Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation.
Toxicology 2003;185(1-2):103-17.
2003: Jonathan G Moggs; Damian G Deavall; George Orphanides
Sex steroids, ANGELS and osteoporosis.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(3):195-9.
2002: Susan Hasmall; George Orphanides; Neil James; William D Pennie; Kathryn Hedley; Anthony Soames; Ian Kimber; Ruth Roberts
Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):304-13.
2002: Helen Tinwell; Paul A Lefevre; Graeme J Moffat; A Burns; Jenny Odum; T D Spurway; George Orphanides; John Ashby
Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.
Environmental health perspectives 2002;110(5):533-6.
2002: George Orphanides; Danny Reinberg
A unified theory of gene expression.
Cell 2002;108(4):439-51.
2001: Jonathan G Moggs; George Orphanides
Estrogen receptors: orchestrators of pleiotropic cellular responses.
EMBO reports 2001;2(9):775-81.
2001: Ruth A Roberts; NH James; SC Cosulich; Susan Hasmall; George Orphanides
Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?
Toxicology letters 2001;120(1-3):301-6.
1999: George Orphanides; WH Wu; William Stratton Lane; Michael Hampsey; Danny Reinberg
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.
Nature 1999;400(6741):284-8.
1998: Gary LeRoy; George Orphanides; William Stratton Lane; Danny Reinberg
Requirement of RSF and FACT for transcription of chromatin templates in vitro.
Science (New York, N.Y.) 1998;282(5395):1900-4.
1998: Helen Cho; George Orphanides; X Sun; X J Yang; V Ogryzko; E Lees; Yoshihiro Nakatani; Danny Reinberg
A human RNA polymerase II complex containing factors that modify chromatin structure.
Molecular and cellular biology 1998;18(9):5355-63.
1998: George Orphanides; Gary LeRoy; C H Chang; Donal S Luse; Danny Reinberg
FACT, a factor that facilitates transcript elongation through nucleosomes.
Cell 1998;92(1):105-16.
1998: Danny Reinberg; George Orphanides; Richard H. Ebright; S Akoulitchev; J Carcamo; Helen Cho; Patricia Cortes; Ronny Drapkin; O Flores; I Ha; J A Inostroza; Sungjoon Kim; Tae-kyung Kim; P Kumar; T Lagrange; Gary LeRoy; H Lu; D M Ma; E Maldonado; A Merino; F Mermelstein; I Olave; M Sheldon; Ramin Shiekhattar; L Zawel
The RNA polymerase II general transcription factors: past, present, and future.
Cold Spring Harbor symposia on quantitative biology 1998;63():83-103.
1996: George Orphanides; T Lagrange; Danny Reinberg
The general transcription factors of RNA polymerase II.
Genes & development 1996;10(21):2657-83.
1996: T Lagrange; Tae-kyung Kim; George Orphanides; Y W Ebright; Richard H. Ebright; Danny Reinberg
High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10620-5.