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Sten Orrenius

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
51
Zhivotovsky, Boris
40
Nicotera, Pierluigi
24
Gogvadze, Vladimir
15
Fadeel, Bengt
14
Robertson, John
14
Slater, AF
13
Chow, Sek
10
Samali, Afshin
9
Hampton, Mark
8
Ceccatelli, Sandra
8
Nobel, CS
7
Jones, Dean
7
Burgess, DH
7
Burkitt, Mark
7
Cotgreave, Ian

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Publications

TOP 3
Ott M; Norberg E; Zhivotovsky B; Orrenius S
Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
Zhivotovsky Boris; Orrenius Sten
Clinical perspectives of cell death: where we are and where to go...
Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Mitochondria as targets for chemotherapy.

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All Publications

2009: Ott M; Norberg E; Zhivotovsky B; Orrenius S
Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
Cell death and differentiation 2009;16(8):1075-82.
2009: Zhivotovsky Boris; Orrenius Sten
Clinical perspectives of cell death: where we are and where to go...
Apoptosis : an international journal on programmed cell death 2009;14(4):333-5.
2009: Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Mitochondria as targets for chemotherapy.
Apoptosis : an international journal on programmed cell death 2009;14(4):624-40.
2009: Zhivotovsky Boris; Orrenius Sten
The Warburg Effect returns to the cancer stage.
Seminars in cancer biology 2009;19(1):1-3.
2009: Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Mitochondria as targets for cancer chemotherapy.
Seminars in cancer biology 2009;19(1):57-66.
2008: Norberg E; Gogvadze V; Ott M; Horn M; Uhlén P; Orrenius S; Zhivotovsky B
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death.
Cell death and differentiation 2008;15(12):1857-64.
2008: Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Mitochondria in cancer cells: what is so special about them?
Trends in cell biology 2008;18(4):165-73.
2008: Vakifahmetoglu H; Olsson M; Tamm C; Heidari N; Orrenius S; Zhivotovsky B
DNA damage induces two distinct modes of cell death in ovarian carcinomas.
Cell death and differentiation 2008;15(3):555-66.
2007: Ott Martin; Norberg Erik; Walter Katharina M; Schreiner Patrick; Kemper Christian; Rapaport Doron; Zhivotovsky Boris; Orrenius Sten
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.
The Journal of biological chemistry 2007;282(38):27633-9.
2007: Ott M; Zhivotovsky B; Orrenius S
Role of cardiolipin in cytochrome c release from mitochondria.
Cell death and differentiation 2007;14(7):1243-7.
2007: Ott Martin; Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Mitochondria, oxidative stress and cell death.
Apoptosis : an international journal on programmed cell death 2007;12(5):913-22.
2007: Witasp E; Uthaisang W; Elenström-Magnusson C; Hanayama R; Tanaka M; Nagata S; Orrenius S; Fadeel B
Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells.
Cell death and differentiation 2007;14(5):1063-5.
2007: Mok K Hun; Pettersson Jenny; Orrenius Sten; Svanborg Catharina
HAMLET, protein folding, and tumor cell death.
Biochemical and biophysical research communications 2007;354(1):1-7.
2007: Orrenius Sten
Reactive oxygen species in mitochondria-mediated cell death.
Drug metabolism reviews 2007;39(2-3):443-55.
2007: Orrenius Sten; Gogvadze Vladimir; Zhivotovsky Boris
Mitochondrial oxidative stress: implications for cell death.
Annual review of pharmacology and toxicology 2007;47():143-83.
2006: Gogvadze Vladimir; Orrenius Sten
Mitochondrial regulation of apoptotic cell death.
Chemico-biological interactions 2006;163(1-2):4-14.
2006: Zhivotovsky Boris; Orrenius Sten
Carcinogenesis and apoptosis: paradigms and paradoxes.
Carcinogenesis 2006;27(10):1939-45.
2006: Vakifahmetoglu H; Olsson M; Orrenius S; Zhivotovsky B
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.
Oncogene 2006;25(41):5683-92.
2006: Orrenius Sten; Zhivotovsky Boris
The future of toxicology--does it matter how cells die?
Chemical research in toxicology 2006;19(6):729-33.
2006: Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Multiple pathways of cytochrome c release from mitochondria in apoptosis.
Biochimica et biophysica acta 2006;1757(5-6):639-47.
2006: Orrenius Sten
Early work on apoptosis, an interview with Sten Orrenius.
Cell death and differentiation 2006;13(1):1-4.
2005: Orrenius Sten; Zhivotovsky Boris
Cardiolipin oxidation sets cytochrome c free.
Nature chemical biology 2005;1(4):188-9.
2005: Bustamante Juanita; Nutt Leta; Orrenius Sten; Gogvadze Vladimir
Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.
Toxicology and applied pharmacology 2005;207(2 Suppl):110-6.
2005: Zhivotovsky Boris; Orrenius Sten
Caspase-2 function in response to DNA damage.
Biochemical and biophysical research communications 2005;331(3):859-67.
2005: Sun Yu; Orrenius Sten; Pervaiz Shazib; Fadeel Bengt
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.
Blood 2005;105(10):4070-7.
2005: Nutt Leta K; Gogvadze Vladimir; Uthaisang Wanlaya; Mirnikjoo Banafsheh; McConkey David J; Orrenius Sten
Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.
Cancer biology & therapy 2005;4(4):459-67.
2005: Fariss Marc W; Chan Catherine B; Patel Manisha; Van Houten Bennett; Orrenius Sten
Role of mitochondria in toxic oxidative stress.
Molecular interventions 2005;5(2):94-111.
2005: Enoksson Mari; Fernandes Aristi Potamitou; Prast Stefanie; Lillig Christopher Horst; Holmgren Arne; Orrenius Sten
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release.
Biochemical and biophysical research communications 2005;327(3):774-9.
2004: Enoksson Mari; Robertson John D; Gogvadze Vladimir; Bu Pengli; Kropotov Andrey; Zhivotovsky Boris; Orrenius Sten
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids.
The Journal of biological chemistry 2004;279(48):49575-8.
2004: Fadeel Bengt; Karpova Maria B; Enoksson Mari; Orrenius Sten
Phosphatidylserine externalization in cardiolipin-deficient cells.
Blood 2004;104(5):1582-3; author reply 1583-4.
2004: Robertson John D; Gogvadze Vladimir; Kropotov Andrey; Vakifahmetoglu Helin; Zhivotovsky Boris; Orrenius Sten
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity.
EMBO reports 2004;5(6):643-8.
2004: Tamm Christoffer; Robertson John D; Sleeper Eric; Enoksson Mari; Emgård Mia; Orrenius Sten; Ceccatelli Sandra
Differential regulation of the mitochondrial and death receptor pathways in neural stem cells.
The European journal of neuroscience 2004;19(10):2613-21.
2004: Ceccatelli S; Tamm C; Sleeper E; Orrenius S
Neural stem cells and cell death.
Toxicology letters 2004;149(1-3):59-66.
2004: Orrenius Sten
Mitochondrial regulation of apoptotic cell death.
Toxicology letters 2004;149(1-3):19-23.
2004: Iverson Suzanne L; Orrenius Sten
The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis.
Archives of biochemistry and biophysics 2004;423(1):37-46.
2004: Gogvadze Vladimir; Robertson John D; Enoksson Mari; Zhivotovsky Boris; Orrenius Sten
Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.
The Biochemical journal 2004;378(Pt 1):213-7.
2004: Fadeel Bengt; Orrenius Sten; Pervaiz Shazib
Buried alive: a novel approach to cancer treatment.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):1-4.
2004: Iverson Suzanne L; Enoksson Mari; Gogvadze Vladimir; Ott Martin; Orrenius Sten
Cardiolipin is not required for Bax-mediated cytochrome c release from yeast mitochondria.
The Journal of biological chemistry 2004;279(2):1100-7.
2003: Gogvadze Vladimir; Orrenius Sten; Zhivotovsky Boris
Analysis of mitochondrial dysfunction during cell death.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2003;Chapter 18():Unit 18.5.
2003: Orrenius Sten; Zhivotovsky Boris; Nicotera Pierluigi
Regulation of cell death: the calcium-apoptosis link.
Nature reviews. Molecular cell biology 2003;4(7):552-65.
2003: Uthaisang Wanlaya; Nutt Leta K; Orrenius Sten; Fadeel Bengt
Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent.
FEBS letters 2003;545(2-3):110-4.
2003: Robertson J D; Zhivotovsky B; Gogvadze V; Orrenius S
Outer mitochondrial membrane permeabilization: an open-and-shut case?
Cell death and differentiation 2003;10(5):485-7.
2003: Zhivotovsky Boris; Orrenius Sten
Defects in the apoptotic machinery of cancer cells: role in drug resistance.
Seminars in cancer biology 2003;13(2):125-34.
2003: Söderdahl Therese; Enoksson Mari; Lundberg Mathias; Holmgren Arne; Ottersen Ole P; Orrenius Sten; Bolcsfoldi George; Cotgreave Ian A
Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):124-6.
2002: Robertson John D; Orrenius Sten
Role of mitochondria in toxic cell death.
Toxicology 2002;181-182():491-6.
2002: Sleeper E; Tamm C; Frisén J; Zhivotovsky B; Orrenius S; Ceccatelli S
Cell death in adult neural stem cells.
Cell death and differentiation 2002;9(12):1377-8.
2002: Lendahl Urban; Orrenius Sten
[Sydney Brenner, Robert Horvitz and John Sulston. Winners of the 2002 Nobel Prize in medicine or physiology. Genetic regulation of organ development and programmed cell death]
Läkartidningen 2002;99(41):4026-32.
2002: Robertson John D; Enoksson Mari; Suomela Minna; Zhivotovsky Boris; Orrenius Sten
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.
The Journal of biological chemistry 2002;277(33):29803-9.
2002: Kagan Valerian E; Gleiss Bettina; Tyurina Yulia Y; Tyurin Vladimir A; Elenström-Magnusson Carina; Liu Shang-Xi; Serinkan F Behice; Arroyo Antonio; Chandra Joya; Orrenius Sten; Fadeel Bengt
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):487-99.
2002: Köhler Camilla; Orrenius Sten; Zhivotovsky Boris
Evaluation of caspase activity in apoptotic cells.
Journal of immunological methods 2002;265(1-2):97-110.
2002: Gleiss Bettina; Gogvadze Vladimir; Orrenius Sten; Fadeel Bengt
Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP.
FEBS letters 2002;519(1-3):153-8.
2002: Robertson J D; Fadeel B; Zhivotovsky B; Orrenius S
'Centennial' Nobel Conference on apoptosis and human disease.
Cell death and differentiation 2002;9(4):468-75.
2002: Gogvadze Vladimir; Stridh Helene; Orrenius Sten; Cotgreave Ian
Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms.
Biochemical and biophysical research communications 2002;292(4):904-8.
2002: Ott Martin; Robertson John D; Gogvadze Vladimir; Zhivotovsky Boris; Orrenius Sten
Cytochrome c release from mitochondria proceeds by a two-step process.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1259-63.
2002: Chandra Joya; Mansson Emma; Gogvadze Vladimir; Kaufmann Scott H; Albertioni Freidoun; Orrenius Sten
Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release.
Blood 2002;99(2):655-63.
2001: Zhivotosky B; Orrenius S
Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.3.
2001: Zhivotovsky B; Orrenius S
Current concepts in cell death.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.1.
2001: Stridh H; Cotgreave I; Müller M; Orrenius S; Gigliotti D
Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes.
Chemical research in toxicology 2001;14(7):791-8.
2001: Fadeel B; Orrenius S; Henter J I
Familial hemophagocytic lymphohistiocytosis: too little cell death can seriously damage your health.
Leukemia & lymphoma 2001;42(1-2):13-20.
2001: Gogvadze V; Robertson J D; Zhivotovsky B; Orrenius S
Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.
The Journal of biological chemistry 2001;276(22):19066-71.
2001: Samali A; Robertson J D; Peterson E; Manero F; van Zeijl L; Paul C; Cotgreave I A; Arrigo A P; Orrenius S
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli.
Cell stress & chaperones 2001;6(1):49-58.
2001: Köhler C; Gogvadze V; Håkansson A; Svanborg C; Orrenius S; Zhivotovsky B
A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria.
European journal of biochemistry / FEBS 2001;268(1):186-91.
2001: Robertson J D; Chandra J; Gogvadze V; Orrenius S
Biological reactive intermediates and mechanisms of cell death.
Advances in experimental medicine and biology 2001;500():1-10.
2000: Robertson J D; Gogvadze V; Zhivotovsky B; Orrenius S
Distinct pathways for stimulation of cytochrome c release by etoposide.
The Journal of biological chemistry 2000;275(42):32438-43.
2000: Gorman A M; Ceccatelli S; Orrenius S
Role of mitochondria in neuronal apoptosis.
Developmental neuroscience 2000;22(5-6):348-58.
2000: Robertson J D; Orrenius S
Molecular mechanisms of apoptosis induced by cytotoxic chemicals.
Critical reviews in toxicology 2000;30(5):609-27.
2000: Robertson J D; Orrenius S; Zhivotovsky B
Review: nuclear events in apoptosis.
Journal of structural biology 2000;129(2-3):346-58.
2000: Gorman A M; Hirt U A; Orrenius S; Ceccatelli S
Dexamethasone pre-treatment interferes with apoptotic death in glioma cells.
Neuroscience 2000;96(2):417-25.
1999: Fadeel B; Orrenius S; Zhivotovsky B
Apoptosis in human disease: a new skin for the old ceremony?
Biochemical and biophysical research communications 1999;266(3):699-717.
1999: Fadeel B; Gleiss B; Högstrand K; Chandra J; Wiedmer T; Sims P J; Henter J I; Orrenius S; Samali A
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.
Biochemical and biophysical research communications 1999;266(2):504-11.
1999: Stridh H; Gigliotti D; Orrenius S; Cotgreave I
The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis.
Biochemical and biophysical research communications 1999;266(2):460-5.
1999: Samali A; Holmberg C I; Sistonen L; Orrenius S
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins.
FEBS letters 1999;461(3):306-10.
1999: Stridh H; Fava E; Single B; Nicotera P; Orrenius S; Leist M
Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production.
Chemical research in toxicology 1999;12(10):874-82.
1999: Fadeel B; Zhivotovsky B; Orrenius S
All along the watchtower: on the regulation of apoptosis regulators.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(13):1647-57.
1999: Fadeel B; Orrenius S; Henter J I
Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients.
British journal of haematology 1999;106(2):406-15.
1999: Zhivotovsky B; Samali A; Gahm A; Orrenius S
Caspases: their intracellular localization and translocation during apoptosis.
Cell death and differentiation 1999;6(7):644-51.
1999: Gorman A M; Hirt U A; Zhivotovsky B; Orrenius S; Ceccatelli S
Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo.
Journal of immunological methods 1999;226(1-2):43-8.
1999: Samali A; Zhivotovsky B; Jones D; Nagata S; Orrenius S
Apoptosis: cell death defined by caspase activation.
Cell death and differentiation 1999;6(6):495-6.
1999: Köhler C; Håkansson A; Svanborg C; Orrenius S; Zhivotovsky B
Protease activation in apoptosis induced by MAL.
Experimental cell research 1999;249(2):260-8.
1999: Samali A; Cai J; Zhivotovsky B; Jones D P; Orrenius S
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
The EMBO journal 1999;18(8):2040-8.
1999: Stridh H; Orrenius S; Hampton M B
Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin.
Toxicology and applied pharmacology 1999;156(2):141-6.
1999: Zhivotovsky B; Joseph B; Orrenius S
Tumor radiosensitivity and apoptosis.
Experimental cell research 1999;248(1):10-7.
1999: Köhler C; Gahm A; Noma T; Nakazawa A; Orrenius S; Zhivotovsky B
Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis.
FEBS letters 1999;447(1):10-2.
1999: Burgess D H; Svensson M; Dandrea T; Grönlund K; Hammarquist F; Orrenius S; Cotgreave I A
Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1.
Cell death and differentiation 1999;6(3):256-61.
1999: Gorman A M; Bonfoco E; Zhivotovsky B; Orrenius S; Ceccatelli S
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells.
The European journal of neuroscience 1999;11(3):1067-72.
1999: Samali A; Nordgren H; Zhivotovsky B; Peterson E; Orrenius S
A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis.
Biochemical and biophysical research communications 1999;255(1):6-11.
1998: Hampton M B; Orrenius S
Redox regulation of apoptotic cell death in the immune system.
Toxicology letters 1998;102-103():355-8.
1998: Pörn-Ares M I; Samali A; Orrenius S
Cleavage of the calpain inhibitor, calpastatin, during apoptosis.
Cell death and differentiation 1998;5(12):1028-33.
1998: Samali A; Orrenius S
Heat shock proteins: regulators of stress response and apoptosis.
Cell stress & chaperones 1998;3(4):228-36.
1998: Fadeel B; Ahlin A; Henter J I; Orrenius S; Hampton M B
Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species.
Blood 1998;92(12):4808-18.
1998: Hampton M B; Fadeel B; Orrenius S
Redox regulation of the caspases during apoptosis.
Annals of the New York Academy of Sciences 1998;854():328-35.
1998: Samali A; Zhivotovsky B; Jones D P; Orrenius S
Detection of pro-caspase-3 in cytosol and mitochondria of various tissues.
FEBS letters 1998;431(2):167-9.
1998: Gorman A M; Orrenius S; Ceccatelli S
Apoptosis in neuronal cells: role of caspases.
Neuroreport 1998;9(10):R49-55.
1998: Stridh H; Kimland M; Jones D P; Orrenius S; Hampton M B
Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis.
FEBS letters 1998;429(3):351-5.
1998: Burkitt M J; Bishop H S; Milne L; Tsang S Y; Provan G J; Nobel C S; Orrenius S; Slater A F
Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species.
Archives of biochemistry and biophysics 1998;353(1):73-84.
1998: Hampton M B; Zhivotovsky B; Slater A F; Burgess D H; Orrenius S
Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts.
The Biochemical journal 1998;329 ( Pt 1)():95-9.
1997: Nobel C S; Kimland M; Nicholson D W; Orrenius S; Slater A F
Disulfiram is a potent inhibitor of proteases of the caspase family.
Chemical research in toxicology 1997;10(12):1319-24.
1997: Vanags D M; Orrenius S; Aguilar-Santelises M
Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis.
British journal of haematology 1997;99(4):824-31.
1997: Hampton M B; Orrenius S
Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis.
FEBS letters 1997;414(3):552-6.
1997: Vanags D M; Larsson P; Feltenmark S; Jakobsson P J; Orrenius S; Claesson H E; Aguilar-Santelises M
Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells.
Cell death and differentiation 1997;4(6):479-86.
1997: Orrenius S; Burgess D H; Hampton M B; Zhivotovsky B
Mitochondria as the focus of apoptosis research.
Cell death and differentiation 1997;4(6):427-8.
1997: Pörn-Ares M I; Chow S C; Slotte J P; Orrenius S
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
Experimental cell research 1997;235(1):48-54.
1997: Nobel C S; Burgess D H; Zhivotovsky B; Burkitt M J; Orrenius S; Slater A F
Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme.
Chemical research in toxicology 1997;10(6):636-43.
1997: Rossi A D; Viviani B; Zhivotovsky B; Manzo L; Orrenius S; Vahter M; Nicotera P
Inorganic mercury modifies Ca2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons.
Cell death and differentiation 1997;4(4):317-24.
1997: Chow S C; Snowden R; Orrenius S; Cohen G M
Susceptibility of different subsets of immature thymocytes to apoptosis.
FEBS letters 1997;408(2):141-6.
1997: Zhivotovsky B; Gahm A; Orrenius S
Two different proteases are involved in the proteolysis of lamin during apoptosis.
Biochemical and biophysical research communications 1997;233(1):96-101.
1997: Bustamante J; Dock L; Vahter M; Fowler B; Orrenius S
The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes.
Toxicology 1997;118(2-3):129-36.
1997: Jiang S; Zhivotovsky B; Burgess D H; Gahm A; Chow S C; Orrenius S
The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+.
Cell death and differentiation 1997;4(1):39-50.
1997: Zhivotovsky B; Burgess D H; Schlegel J; Pörn M I; Vanags D; Orrenius S
Proteases in Fas-mediated apoptosis.
Journal of cellular biochemistry 1997;64(1):43-9.
1997: Zhivotovsky B; Burgess D H; Vanags D M; Orrenius S
Involvement of cellular proteolytic machinery in apoptosis.
Biochemical and biophysical research communications 1997;230(3):481-8.
1997: van den Dobbelsteen D J; Nobel C S; Slater A F; Orrenius S
Regulation and mechanisms of apoptosis in T lymphocytes.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():77-85.
1997: Nicotera P; Ankarcrona M; Bonfoco E; Orrenius S; Lipton S A
Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.
Advances in neurology 1997;72():95-101.
1996: Bonfoco E; Zhivotovsky B; Rossi A D; Aguilar-Santelises M; Orrenius S; Lipton S A; Nicotera P
BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells.
Neuroreport 1996;8(1):273-6.
1996: Hampton M B; Vanags D M; Pörn-Ares M I; Orrenius S
Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis.
FEBS letters 1996;399(3):277-82.
1996: Vanags D M; Pörn-Ares M I; Coppola S; Burgess D H; Orrenius S
Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis.
The Journal of biological chemistry 1996;271(49):31075-85.
1996: Bonfoco E; Leist M; Zhivotovsky B; Orrenius S; Lipton S A; Nicotera P
Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation.
Journal of neurochemistry 1996;67(6):2484-93.
1996: Ankarcrona M; Zhivotovsky B; Holmström T; Diana A; Eriksson J E; Orrenius S; Nicotera P
Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis.
Neuroreport 1996;7(15-17):2659-64.
1996: Orrenius S; Nobel C S; van den Dobbelsteen D J; Burkitt M J; Slater A F
Dithiocarbamates and the redox regulation of cell death.
Biochemical Society transactions 1996;24(4):1032-8.
1996: Zhivotovsky B; Burgess D H; Orrenius S
Proteases in apoptosis.
Experientia 1996;52(10-11):968-78.
1996: Ankarcrona M; Dypbukt J M; Orrenius S; Nicotera P
Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.
FEBS letters 1996;394(3):321-4.
1996: Kass G E; Eriksson J E; Weis M; Orrenius S; Chow S C
Chromatin condensation during apoptosis requires ATP.
The Biochemical journal 1996;318 ( Pt 3)():749-52.
1996: van den Dobbelsteen D J; Nobel C S; Schlegel J; Cotgreave I A; Orrenius S; Slater A F
Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody.
The Journal of biological chemistry 1996;271(26):15420-7.
1996: Slater A F; Stefan C; Nobel I; van den Dobbelsteen D J; Orrenius S
Intracellular redox changes during apoptosis.
Cell death and differentiation 1996;3(1):57-62.
1996: Schlegel J; Peters I; Orrenius S; Miller D K; Thornberry N A; Yamin T T; Nicholson D W
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis.
The Journal of biological chemistry 1996;271(4):1841-4.
1996: Burkitt M J; Milne L; Nicotera P; Orrenius S
1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.
The Biochemical journal 1996;313 ( Pt 1)():163-9.
1996: Orrenius S; Ankarcrona M; Nicotera P
Mechanisms of calcium-related cell death.
Advances in neurology 1996;71():137-49; discussion 149-51.
1995: Slater A F; Stefan C; Nobel I; van den Dobbelsteen D J; Orrenius S
Signalling mechanisms and oxidative stress in apoptosis.
Toxicology letters 1995;82-83():149-53.
1995: Slater A F; Kimland M; Jiang S A; Orrenius S
Constitutive nuclear NF kappa B/rel DNA-binding activity of rat thymocytes is increased by stimuli that promote apoptosis, but not inhibited by pyrrolidine dithiocarbamate.
The Biochemical journal 1995;312 ( Pt 3)():833-8.
1995: Zhivotovsky B; Gahm A; Ankarcrona M; Nicotera P; Orrenius S
Multiple proteases are involved in thymocyte apoptosis.
Experimental cell research 1995;221(2):404-12.
1995: Nobel C I; Kimland M; Lind B; Orrenius S; Slater A F
Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper.
The Journal of biological chemistry 1995;270(44):26202-8.
1995: Bustamante J; Slater A F; Orrenius S
Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid.
Free radical biology & medicine 1995;19(3):339-47.
1995: Håkansson A; Zhivotovsky B; Orrenius S; Sabharwal H; Svanborg C
Apoptosis induced by a human milk protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8064-8.
1995: Weis M; Schlegel J; Kass G E; Holmström T H; Peters I; Eriksson J; Orrenius S; Chow S C
Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes.
Experimental cell research 1995;219(2):699-708.
1995: Jiang S; Chow S C; McCabe M J; Orrenius S
Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.
Laboratory investigation; a journal of technical methods and pathology 1995;73(1):111-7.
1995: Slater A F; Nobel C S; Orrenius S
The role of intracellular oxidants in apoptosis.
Biochimica et biophysica acta 1995;1271(1):59-62.
1995: Schlegel J; Peters I; Orrenius S
Isolation and partial characterization of a protease involved in Fas-induced apoptosis.
FEBS letters 1995;364(2):139-42.
1995: Chow S C; Weis M; Kass G E; Holmström T H; Eriksson J E; Orrenius S
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes.
FEBS letters 1995;364(2):134-8.
1995: Slater A F; Nobel C S; Maellaro E; Bustamante J; Kimland M; Orrenius S
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis.
The Biochemical journal 1995;306 ( Pt 3)():771-8.
1995: Chow S C; Peters I; Orrenius S
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis.
Experimental cell research 1995;216(1):149-59.
1994: Dypbukt J M; Ankarcrona M; Burkitt M; Sjöholm A; Ström K; Orrenius S; Nicotera P
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.
The Journal of biological chemistry 1994;269(48):30553-60.
1994: Zhivotovsky B; Wade D; Nicotera P; Orrenius S
Role of nucleases in apoptosis.
International archives of allergy and immunology 1994;105(4):333-8.
1994: Nicotera P; Zhivotovsky B; Orrenius S
Nuclear calcium transport and the role of calcium in apoptosis.
Cell calcium 1994;16(4):279-88.
1994: Kass G E; Chow S C; Gahm A; Webb D L; Berggren P O; Llopis J; Orrenius S
Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes.
Biochimica et biophysica acta 1994;1223(2):226-33.
1994: Zhivotovsky B; Wade D; Gahm A; Orrenius S; Nicotera P
Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation.
FEBS letters 1994;351(2):150-4.
1994: Chow S C; Orrenius S
Rapid cytoskeleton modification in thymocytes induced by the immunotoxicant tributyltin.
Toxicology and applied pharmacology 1994;127(1):19-26.
1994: Zhivotovsky B; Cedervall B; Jiang S; Nicotera P; Orrenius S
Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis.
Biochemical and biophysical research communications 1994;202(1):120-7.
1994: Weis M; Kass G E; Orrenius S
Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants.
Biochemical pharmacology 1994;47(12):2147-56.
1994: Jiang S; Chow S C; Nicotera P; Orrenius S
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin.
Experimental cell research 1994;212(1):84-92.
1993: Rossi A D; Larsson O; Manzo L; Orrenius S; Vahter M; Berggren P O; Nicotera P
Modifications of Ca2+ signaling by inorganic mercury in PC12 cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(15):1507-14.
1993: McCabe M J; Orrenius S
Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.
Biochemical and biophysical research communications 1993;194(2):944-50.
1993: Zhivotovsky B; Nicotera P; Bellomo G; Hanson K; Orrenius S
Ca2+ and endonuclease activation in radiation-induced lymphoid cell death.
Experimental cell research 1993;207(1):163-70.
1993: Chow S C; Kass G E; Orrenius S
Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation.
The Biochemical journal 1993;293 ( Pt 2)():395-8.
1993: McCabe M J; Jiang S A; Orrenius S
Chelation of intracellular zinc triggers apoptosis in mature thymocytes.
Laboratory investigation; a journal of technical methods and pathology 1993;69(1):101-10.
1993: Milne L; Nicotera P; Orrenius S; Burkitt M J
Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione.
Archives of biochemistry and biophysics 1993;304(1):102-9.
1993: Llopis J; Farrell G C; Duddy S K; Kass G E; Gahm A; Orrenius S
Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver.
Biochemical pharmacology 1993;45(11):2209-14.
1993: McConkey D J; Orrenius S; Okret S; Jondal M
Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(6):580-5.
1992: Nicotera P; Dypbukt J M; Rossi A D; Manzo L; Orrenius S
Thiol modification and cell signalling in chemical toxicity.
Toxicology letters 1992;64-65 Spec No():563-7.
1992: Orrenius S; McCabe M J; Nicotera P
Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death.
Toxicology letters 1992;64-65 Spec No():357-64.
1992: Kass G E; Juedes M J; Orrenius S
Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity.
Biochemical pharmacology 1992;44(10):1995-2003.
1992: Juedes M J; Kass G E; Orrenius S
m-iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes.
FEBS letters 1992;313(1):39-42.
1992: McCabe M J; Nicotera P; Orrenius S
Calcium-dependent cell death. Role of the endonuclease, protein kinase C, and chromatin conformation.
Annals of the New York Academy of Sciences 1992;663():269-78.
1992: Chow S C; Kass G E; McCabe M J; Orrenius S
Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux.
Archives of biochemistry and biophysics 1992;298(1):143-9.
1992: Nicotera P; Orrenius S
Ca2+ and cell death.
Annals of the New York Academy of Sciences 1992;648():17-27.
1992: Llopis J; Kass G E; Gahm A; Orrenius S
Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes.
The Biochemical journal 1992;284 ( Pt 1)():243-7.
1992: Dypbukt J M; Costa L G; Manzo L; Orrenius S; Nicotera P
Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells.
Carcinogenesis 1992;13(3):417-24.
1992: Weis M; Kass G E; Orrenius S; Moldéus P
N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.
The Journal of biological chemistry 1992;267(2):804-9.
1992: Orrenius S; Burkitt M J; Kass G E; Dypbukt J M; Nicotera P
Calcium ions and oxidative cell injury.
Annals of neurology 1992;32 Suppl():S33-42.
1991: Brüne B; Hartzell P; Nicotera P; Orrenius S
Spermine prevents endonuclease activation and apoptosis in thymocytes.
Experimental cell research 1991;195(2):323-9.
1991: Llopis J; Chow S B; Kass G E; Gahm A; Orrenius S
Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes.
The Biochemical journal 1991;277 ( Pt 2)():553-6.
1991: Llopis J; Kass G E; Duddy S K; Farell G C; Gahm A; Orrenius S
Mobilization of the hormone-sensitive calcium pool increases hepatocyte tight junctional permeability in the perfused rat liver.
FEBS letters 1991;280(1):84-6.
1991: McConkey D J; Aguilar-Santelises M; Hartzell P; Eriksson I; Mellstedt H; Orrenius S; Jondal M
Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):1072-6.
1991: Orrenius S; McConkey D J; Nicotera P
Role of calcium in toxic and programmed cell death.
Advances in experimental medicine and biology 1991;283():419-25.
1990: Aw T Y; Nicotera P; Manzo L; Orrenius S
Tributyltin stimulates apoptosis in rat thymocytes.
Archives of biochemistry and biophysics 1990;283(1):46-50.
1990: Nicotera P; Bellomo G; Orrenius S
The role of Ca2+ in cell killing.
Chemical research in toxicology 1990;3(6):484-94.
1990: Kass G E; Llopis J; Chow S C; Duddy S K; Orrenius S
Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.
The Journal of biological chemistry 1990;265(29):17486-92.
1990: Nicotera P; Orrenius S; Nilsson T; Berggren P O
An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6858-62.
1990: McConkey D J; Orrenius S; Jondal M
Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1227-30.
1990: McConkey D J; Chow S C; Orrenius S; Jondal M
NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(9):2661-4.
1990: Farrell G C; Duddy S K; Kass G E; Llopis J; Gahm A; Orrenius S
Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver.
The Journal of clinical investigation 1990;85(4):1255-9.
1990: McConkey D J; Hartzell P; Orrenius S
Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis.
Archives of biochemistry and biophysics 1990;278(1):284-7.
1990: McConkey D J; Hartzell P; Chow S C; Orrenius S; Jondal M
Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.
The Journal of biological chemistry 1990;265(6):3009-11.
1990: Moore G A; Kass G E; Duddy S K; Farrell G C; Llopis J; Orrenius S
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel mobilizer of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
Free radical research communications 1990;8(4-6):337-45.
1989: Duddy S K; Kass G E; Orrenius S
Ca2(+)-mobilizing hormones stimulate Ca2+ efflux from hepatocytes.
The Journal of biological chemistry 1989;264(35):20863-6.
1989: Kass G E; Duddy S K; Moore G A; Orrenius S
2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
The Journal of biological chemistry 1989;264(26):15192-8.
1989: McConkey D J; Hartzell P; Amador-Pérez J F; Orrenius S; Jondal M
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(6):1801-6.
1989: McConkey D J; Hartzell P; Jondal M; Orrenius S
Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.
The Journal of biological chemistry 1989;264(23):13399-402.
1989: Kass G E; Duddy S K; Orrenius S
Activation of hepatocyte protein kinase C by redox-cycling quinones.
The Biochemical journal 1989;260(2):499-507.
1989: McConkey D J; Orrenius S
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo.
Biochemical and biophysical research communications 1989;160(3):1003-8.
1989: McConkey D J; Hartzell P; Nicotera P; Orrenius S
Calcium-activated DNA fragmentation kills immature thymocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(7):1843-9.
1989: Jones D P; McConkey D J; Nicotera P; Orrenius S
Calcium-activated DNA fragmentation in rat liver nuclei.
The Journal of biological chemistry 1989;264(11):6398-403.
1989: McConkey D J; Nicotera P; Hartzell P; Bellomo G; Wyllie A H; Orrenius S
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.
Archives of biochemistry and biophysics 1989;269(1):365-70.
1989: Nicotera P; McConkey D J; Jones D P; Orrenius S
ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):453-7.
1989: Nicotera P; Thor H; Orrenius S
Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(1):59-64.
1989: Nicotera P; Rundgren M; Porubek D J; Cotgreave I; Moldéus P; Orrenius S; Nelson S D
On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes.
Chemical research in toxicology 1989;2(1):46-50.
1989: Nicotera P; McConkey D J; Dypbukt J M; Jones D P; Orrenius S
Ca2+-activated mechanisms in cell killing.
Drug metabolism reviews 1989;20(2-4):193-201.
1988: Moore G A; Weis M; Orrenius S; O'Brien P J
Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria.
Archives of biochemistry and biophysics 1988;267(2):539-50.
1988: Nicotera P; McConkey D; Svensson S A; Bellomo G; Orrenius S
Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress.
Toxicology 1988;52(1-2):55-63.
1988: McConkey D J; Hartzell P; Duddy S K; Håkansson H; Orrenius S
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
Science (New York, N.Y.) 1988;242(4876):256-9.
1988: McConkey D J; Hartzell P; Nicotera P; Wyllie A H; Orrenius S
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.
Toxicology letters 1988;42(2):123-30.
1988: Kass G E; Wright J M; Nicotera P; Orrenius S
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
Archives of biochemistry and biophysics 1988;260(2):789-97.
1987: Moore G A; Rossi L; Nicotera P; Orrenius S; O'Brien P J
Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives.
Archives of biochemistry and biophysics 1987;259(2):283-95.
1987: Moore G A; McConkey D J; Kass G E; O'Brien P J; Orrenius S
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration.
FEBS letters 1987;224(2):331-6.
1987: Orrenius S; Nicotera P
Biochemical mechanisms of oxidative liver cell injury.
Bulletin européen de physiopathologie respiratoire 1987;23(4):291-5.
1986: Mirabelli F; Bellomo G; Nicotera P; Moore M; Orrenius S
Ca2+ homeostasis and cytotoxicity in isolated hepatocytes: studies with extracellular adenosine 5'-triphosphate.
Journal of biochemical toxicology 1986;1(1):29-39.
1986: Eklöw-Låstbom L; Rossi L; Thor H; Orrenius S
Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.
Free radical research communications 1986;2(1-2):57-68.

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