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Sten Orrenius

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Emiliano Panieri; Rithika Venkatesh; Vladimir Gogvadze; Erik Norberg; Sten Orrenius; Boris Zhivotovsky
Reactive oxygen species generated in different compartments induce cell death, survival, or senescence.
Raúl González; Clara I Linares; Patricia Aguilar-Melero; José M Alamo; J Antonio Bárcena; Rosario I Bello; Manuel De la Mata; Gustavo Ferrín; Vladimir Gogvadze; Sten Orrenius; Francisco J Padillo; Isidora Ranchal; Boris Zhivotovsky; Jordi Muntané
Targeting hepatoma using nitric oxide donor strategies.
Sten Orrenius; Vitaliy O Kaminskyy; Boris Zhivotovsky
Autophagy in toxicology: cause or consequence?

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2013: Emiliano Panieri; Rithika Venkatesh; Vladimir Gogvadze; Erik Norberg; Sten Orrenius; Boris Zhivotovsky
Reactive oxygen species generated in different compartments induce cell death, survival, or senescence.
Free radical biology & medicine 2013;57():176-87.
2013: Raúl González; Clara I Linares; Patricia Aguilar-Melero; José M Alamo; J Antonio Bárcena; Rosario I Bello; Manuel De la Mata; Gustavo Ferrín; Vladimir Gogvadze; Sten Orrenius; Francisco J Padillo; Isidora Ranchal; Boris Zhivotovsky; Jordi Muntané
Targeting hepatoma using nitric oxide donor strategies.
Antioxidants & redox signaling 2013;18(5):491-506.
2013: Sten Orrenius; Vitaliy O Kaminskyy; Boris Zhivotovsky
Autophagy in toxicology: cause or consequence?
Annual review of pharmacology and toxicology 2013;53():275-97.
2012: Björn Kruspig; Azadeh Nilchian; Sten Orrenius; Boris Zhivotovsky; Vladimir Gogvadze
Citrate kills tumor cells through activation of apical caspases.
Cellular and molecular life sciences : CMLS 2012;69(24):4229-37.
2012: Björn Kruspig; Azadeh Nilchian; Sten Orrenius; Boris Zhivotovsky; Ignacio Bejarano; Vladimir Gogvadze
Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression.
Cellular and molecular life sciences : CMLS 2012;69(12):2091-9.
2011: Boris Zhivotovsky; Sten Orrenius
Calcium and cell death mechanisms: a perspective from the cell death community.
Cell calcium 2011;50(3):211-21.
2011: Sten Orrenius; Pierluigi Nicotera; Boris Zhivotovsky
Cell death mechanisms and their implications in toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):3-19.
2010: Erik Norberg; Marie Karlsson; Olga Korenovska; Susanne Szydlowski; Gilad Silberberg; Per Uhlén; Sten Orrenius; Boris Zhivotovsky
Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis.
The EMBO journal 2010;29(22):3869-78.
2010: Boris Zhivotovsky; Sten Orrenius
Cell cycle and cell death in disease: past, present and future.
Journal of internal medicine 2010;268(5):395-409.
2010: Vladimir Gogvadze; Erik Norberg; Sten Orrenius; Boris Zhivotovsky
Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization.
International journal of cancer. Journal international du cancer 2010;127(8):1823-32.
2010: Erik Norberg; Sten Orrenius; Boris Zhivotovsky
Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF).
Biochemical and biophysical research communications 2010;396(1):95-100.
2010: Hans Jörnvall; Sten Orrenius
Special issue composed of minireviews written by scientists from Karolinska Institutet to celebrate its 200-year anniversary. Preface.
Biochemical and biophysical research communications 2010;396(1):1.
2010: Boris Zhivotovsky; Sten Orrenius
Cell death mechanisms: cross-talk and role in disease.
Experimental cell research 2010;316(8):1374-83.
2010: Erik Norberg; Vladimir Gogvadze; Helin Vakifahmetoglu; Sten Orrenius; Boris Zhivotovsky
Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing.
Free radical biology & medicine 2010;48(6):791-7.
2010: Vladimir Gogvadze; Boris Zhivotovsky; Sten Orrenius
The Warburg effect and mitochondrial stability in cancer cells.
Molecular aspects of medicine 2010;31(1):60-74.
2009: M Ott; Erik Norberg; Boris Zhivotovsky; Sten Orrenius
Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
Cell death and differentiation 2009;16(8):1075-82.
2009: Boris Zhivotovsky; Sten Orrenius
Clinical perspectives of cell death: where we are and where to go...
Apoptosis : an international journal on programmed cell death 2009;14(4):333-5.
2009: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Mitochondria as targets for chemotherapy.
Apoptosis : an international journal on programmed cell death 2009;14(4):624-40.
2009: Boris Zhivotovsky; Sten Orrenius
The Warburg Effect returns to the cancer stage.
Seminars in cancer biology 2009;19(1):1-3.
2009: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Mitochondria as targets for cancer chemotherapy.
Seminars in cancer biology 2009;19(1):57-66.
2008: Erik Norberg; Vladimir Gogvadze; M Ott; M Horn; Per Uhlén; Sten Orrenius; Boris Zhivotovsky
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death.
Cell death and differentiation 2008;15(12):1857-64.
2008: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Mitochondria in cancer cells: what is so special about them?
Trends in cell biology 2008;18(4):165-73.
2008: H Vakifahmetoglu; M Olsson; Christoffer Tamm; N Heidari; Sten Orrenius; Boris Zhivotovsky
DNA damage induces two distinct modes of cell death in ovarian carcinomas.
Cell death and differentiation 2008;15(3):555-66.
2007: Martin Ott; Erik Norberg; Katharina M Walter; Patrick Schreiner; Christian Kemper; Doron Rapaport; Boris Zhivotovsky; Sten Orrenius
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.
The Journal of biological chemistry 2007;282(38):27633-9.
2007: M Ott; Boris Zhivotovsky; Sten Orrenius
Role of cardiolipin in cytochrome c release from mitochondria.
Cell death and differentiation 2007;14(7):1243-7.
2007: Martin Ott; Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Mitochondria, oxidative stress and cell death.
Apoptosis : an international journal on programmed cell death 2007;12(5):913-22.
2007: Erika Witasp; Wanlaya Uthaisang; C Elenström-Magnusson; R Hanayama; M Tanaka; S Nagata; Sten Orrenius; Bengt Fadeel
Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells.
Cell death and differentiation 2007;14(5):1063-5.
2007: K Hun Mok; Jenny Pettersson; Sten Orrenius; Catharina Svanborg
HAMLET, protein folding, and tumor cell death.
Biochemical and biophysical research communications 2007;354(1):1-7.
2007: Sten Orrenius
Reactive oxygen species in mitochondria-mediated cell death.
Drug metabolism reviews 2007;39(2-3):443-55.
2007: Sten Orrenius; Vladimir Gogvadze; Boris Zhivotovsky
Mitochondrial oxidative stress: implications for cell death.
Annual review of pharmacology and toxicology 2007;47():143-83.
2006: Vladimir Gogvadze; Sten Orrenius
Mitochondrial regulation of apoptotic cell death.
Chemico-biological interactions 2006;163(1-2):4-14.
2006: Boris Zhivotovsky; Sten Orrenius
Carcinogenesis and apoptosis: paradigms and paradoxes.
Carcinogenesis 2006;27(10):1939-45.
2006: H Vakifahmetoglu; M Olsson; Sten Orrenius; Boris Zhivotovsky
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.
Oncogene 2006;25(41):5683-92.
2006: Sten Orrenius; Boris Zhivotovsky
The future of toxicology--does it matter how cells die?
Chemical research in toxicology 2006;19(6):729-33.
2006: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Multiple pathways of cytochrome c release from mitochondria in apoptosis.
Biochimica et biophysica acta 2006;1757(5-6):639-47.
2006: Sten Orrenius
Early work on apoptosis, an interview with Sten Orrenius.
Cell death and differentiation 2006;13(1):1-4.
2005: Sten Orrenius; Boris Zhivotovsky
Cardiolipin oxidation sets cytochrome c free.
Nature chemical biology 2005;1(4):188-9.
2005: Juanita Bustamante; Leta K Nutt; Sten Orrenius; Vladimir Gogvadze
Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.
Toxicology and applied pharmacology 2005;207(2 Suppl):110-6.
2005: Boris Zhivotovsky; Sten Orrenius
Caspase-2 function in response to DNA damage.
Biochemical and biophysical research communications 2005;331(3):859-67.
2005: Yu Sun; Sten Orrenius; Jason Yongsheng Chan; Bengt Fadeel
Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.
Blood 2005;105(10):4070-7.
2005: Leta K Nutt; Vladimir Gogvadze; Wanlaya Uthaisang; Banafsheh Mirnikjoo; David J McConkey; Sten Orrenius
Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.
Cancer biology & therapy 2005;4(4):459-67.
2005: Marc W Fariss; Catherine B Chan; Manisha Patel; Bennett Van Houten; Sten Orrenius
Role of mitochondria in toxic oxidative stress.
Molecular interventions 2005;5(2):94-111.
2005: Mari Enoksson; Aristi Potamitou Fernandes; Stefanie Prast; Christopher Horst Lillig; Arne Holmgren; Sten Orrenius
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release.
Biochemical and biophysical research communications 2005;327(3):774-9.
2004: Mari Enoksson; John D Robertson; Vladimir Gogvadze; Pengli Bu; Andrey Kropotov; Boris Zhivotovsky; Sten Orrenius
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids.
The Journal of biological chemistry 2004;279(48):49575-8.
2004: Bengt Fadeel; Maria B Karpova; Mari Enoksson; Sten Orrenius
Phosphatidylserine externalization in cardiolipin-deficient cells.
Blood 2004;104(5):1582-3; author reply 1583-4.
2004: John D Robertson; Vladimir Gogvadze; Andrey Kropotov; Helin Vakifahmetoglu; Boris Zhivotovsky; Sten Orrenius
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity.
EMBO reports 2004;5(6):643-8.
2004: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Analysis of mitochondrial dysfunction during cell death.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2004;Chapter 2():Unit2.10.
2004: Christoffer Tamm; John D Robertson; Eric Sleeper; Mari Enoksson; Mia Emgård; Sten Orrenius; Sandra Ceccatelli
Differential regulation of the mitochondrial and death receptor pathways in neural stem cells.
The European journal of neuroscience 2004;19(10):2613-21.
2004: Sandra Ceccatelli; Christoffer Tamm; Eric Sleeper; Sten Orrenius
Neural stem cells and cell death.
Toxicology letters 2004;149(1-3):59-66.
2004: Sten Orrenius
Mitochondrial regulation of apoptotic cell death.
Toxicology letters 2004;149(1-3):19-23.
2004: Suzanne L Iverson; Sten Orrenius
The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis.
Archives of biochemistry and biophysics 2004;423(1):37-46.
2004: Vladimir Gogvadze; John D Robertson; Mari Enoksson; Boris Zhivotovsky; Sten Orrenius
Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.
The Biochemical journal 2004;378(Pt 1):213-7.
2004: Suzanne L Iverson; Mari Enoksson; Vladimir Gogvadze; Martin Ott; Sten Orrenius
Cardiolipin is not required for Bax-mediated cytochrome c release from yeast mitochondria.
The Journal of biological chemistry 2004;279(2):1100-7.
2004: Bengt Fadeel; Sten Orrenius; Jason Yongsheng Chan
Buried alive: a novel approach to cancer treatment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):1-4.
2003: Vladimir Gogvadze; Sten Orrenius; Boris Zhivotovsky
Analysis of mitochondrial dysfunction during cell death.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2003;Chapter 18():Unit 18.5.
2003: Sten Orrenius; Boris Zhivotovsky; Pierluigi Nicotera
Regulation of cell death: the calcium-apoptosis link.
Nature reviews. Molecular cell biology 2003;4(7):552-65.
2003: Wanlaya Uthaisang; Leta K Nutt; Sten Orrenius; Bengt Fadeel
Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent.
FEBS letters 2003;545(2-3):110-4.
2003: John D Robertson; Boris Zhivotovsky; Vladimir Gogvadze; Sten Orrenius
Outer mitochondrial membrane permeabilization: an open-and-shut case?
Cell death and differentiation 2003;10(5):485-7.
2003: Boris Zhivotovsky; Sten Orrenius
Defects in the apoptotic machinery of cancer cells: role in drug resistance.
Seminars in cancer biology 2003;13(2):125-34.
2003: Therese Söderdahl; Mari Enoksson; Mathias Lundberg; Arne Holmgren; Ole Petter Ottersen; Sten Orrenius; George Bolcsfoldi; Ian A Cotgreave
Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):124-6.
2002: John D Robertson; Sten Orrenius
Role of mitochondria in toxic cell death.
Toxicology 2002;181-182():491-6.
2002: Eric Sleeper; Christoffer Tamm; J Frisén; B Zhivotovsky; Sten Orrenius; Sandra Ceccatelli
Cell death in adult neural stem cells.
Cell death and differentiation 2002;9(12):1377-8.
2002: Urban Lendahl; Sten Orrenius
[Sydney Brenner, Robert Horvitz and John Sulston. Winners of the 2002 Nobel Prize in medicine or physiology. Genetic regulation of organ development and programmed cell death].
Läkartidningen 2002;99(41):4026-32.
2002: John D Robertson; Mari Enoksson; Minna Suomela; Boris Zhivotovsky; Sten Orrenius
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.
The Journal of biological chemistry 2002;277(33):29803-9.
2002: Valerian E Kagan; Bettina Gleiss; Yulia Y Tyurina; Vladimir A Tyurin; Carina Elenström-Magnusson; Shang-Xi Liu; F Behice Serinkan; Antonio Arroyo; Joya Chandra; Sten Orrenius; Bengt Fadeel
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):487-99.
2002: Camilla Köhler; Sten Orrenius; Boris Zhivotovsky
Evaluation of caspase activity in apoptotic cells.
Journal of immunological methods 2002;265(1-2):97-110.
2002: Bettina Gleiss; Vladimir Gogvadze; Sten Orrenius; Bengt Fadeel
Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP.
FEBS letters 2002;519(1-3):153-8.
2002: Vladimir Gogvadze; Helene Stridh; Sten Orrenius; Ian A Cotgreave
Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms.
Biochemical and biophysical research communications 2002;292(4):904-8.
2002: John D Robertson; Bengt Fadeel; Boris Zhivotovsky; Sten Orrenius
'Centennial' Nobel Conference on apoptosis and human disease.
Cell death and differentiation 2002;9(4):468-75.
2002: Martin Ott; John D Robertson; Vladimir Gogvadze; Boris Zhivotovsky; Sten Orrenius
Cytochrome c release from mitochondria proceeds by a two-step process.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1259-63.
2002: Joya Chandra; Emma Mansson; Vladimir Gogvadze; Scott H Kaufmann; Freidoun Albertioni; Sten Orrenius
Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release.
Blood 2002;99(2):655-63.
2001: B Zhivotosky; Sten Orrenius
Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.3.
2001: Boris Zhivotovsky; Sten Orrenius
Current concepts in cell death.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.1.
2001: Helene Stridh; Ian A Cotgreave; M Müller; Sten Orrenius; D Gigliotti
Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes.
Chemical research in toxicology 2001;14(7):791-8.
2001: Bengt Fadeel; Sten Orrenius; Jan-Inge Henter
Familial hemophagocytic lymphohistiocytosis: too little cell death can seriously damage your health.
Leukemia & lymphoma 2001;42(1-2):13-20.
2001: Vladimir Gogvadze; John D Robertson; Boris Zhivotovsky; Sten Orrenius
Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.
The Journal of biological chemistry 2001;276(22):19066-71.
2001: Boris Zhivotovsky; Afshin Samali; Sten Orrenius
Determination of apoptosis and necrosis.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 2():Unit 2.2.
2001: Afshin Samali; Boris Zhivotovsky; Sten Orrenius
Current concepts in cell toxicity.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 2():Unit 2.1.
2001: John D Robertson; J Chandra; Vladimir Gogvadze; Sten Orrenius
Biological reactive intermediates and mechanisms of cell death.
Advances in experimental medicine and biology 2001;500():1-10.
2001: Afshin Samali; J D Robertson; E Peterson; Florence Manero; L van Zeijl; C Paul; Ian A Cotgreave; André-Patrick Arrigo; Sten Orrenius
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli.
Cell stress & chaperones 2001;6(1):49-58.
2001: C Köhler; Vladimir Gogvadze; A Håkansson; Catharina Svanborg; Sten Orrenius; Boris Zhivotovsky
A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria.
European journal of biochemistry / FEBS 2001;268(1):186-91.
2000: John D Robertson; Vladimir Gogvadze; Boris Zhivotovsky; Sten Orrenius
Distinct pathways for stimulation of cytochrome c release by etoposide.
The Journal of biological chemistry 2000;275(42):32438-43.
2000: Adrienne M Gorman; Sandra Ceccatelli; Sten Orrenius
Role of mitochondria in neuronal apoptosis.
Developmental neuroscience 2000;22(5-6):348-58.
2000: John D Robertson; Sten Orrenius
Molecular mechanisms of apoptosis induced by cytotoxic chemicals.
Critical reviews in toxicology 2000;30(5):609-27.
2000: John D Robertson; Sten Orrenius; Boris Zhivotovsky
Review: nuclear events in apoptosis.
Journal of structural biology 2000;129(2-3):346-58.
2000: Adrienne M Gorman; U A Hirt; Sten Orrenius; Sandra Ceccatelli
Dexamethasone pre-treatment interferes with apoptotic death in glioma cells.
Neuroscience 2000;96(2):417-25.
1999: Bengt Fadeel; Sten Orrenius; Boris Zhivotovsky
Apoptosis in human disease: a new skin for the old ceremony?
Biochemical and biophysical research communications 1999;266(3):699-717.
1999: Bengt Fadeel; Bettina Gleiss; K Högstrand; J Chandra; Therese Wiedmer; Peter J Sims; J I Henter; Sten Orrenius; Afshin Samali
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.
Biochemical and biophysical research communications 1999;266(2):504-11.
1999: Helene Stridh; D Gigliotti; Sten Orrenius; Ian A Cotgreave
The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis.
Biochemical and biophysical research communications 1999;266(2):460-5.
1999: Afshin Samali; C I Holmberg; Lea Sistonen; Sten Orrenius
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins.
FEBS letters 1999;461(3):306-10.
1999: Helene Stridh; Eugenio Fava; B Single; P Nicotera; Sten Orrenius; M Leist
Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production.
Chemical research in toxicology 1999;12(10):874-82.
1999: Bengt Fadeel; B Zhivotovsky; Sten Orrenius
All along the watchtower: on the regulation of apoptosis regulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(13):1647-57.
1999: Bengt Fadeel; Sten Orrenius; Jan-Inge Henter
Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients.
British journal of haematology 1999;106(2):406-15.
1999: Boris Zhivotovsky; Afshin Samali; A Gahm; Sten Orrenius
Caspases: their intracellular localization and translocation during apoptosis.
Cell death and differentiation 1999;6(7):644-51.
1999: Adrienne M Gorman; U A Hirt; Boris Zhivotovsky; Sten Orrenius; Sandra Ceccatelli
Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo.
Journal of immunological methods 1999;226(1-2):43-8.
1999: C Köhler; A Håkansson; Catharina Svanborg; Sten Orrenius; Boris Zhivotovsky
Protease activation in apoptosis induced by MAL.
Experimental cell research 1999;249(2):260-8.
1999: Afshin Samali; B Zhivotovsky; Dean P Jones; S Nagata; Sten Orrenius
Apoptosis: cell death defined by caspase activation.
Cell death and differentiation 1999;6(6):495-6.
1999: Afshin Samali; J Cai; Boris Zhivotovsky; Dean P Jones; Sten Orrenius
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
The EMBO journal 1999;18(8):2040-8.
1999: Helene Stridh; Sten Orrenius; Mark Hampton
Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin.
Toxicology and applied pharmacology 1999;156(2):141-6.
1999: Boris Zhivotovsky; Bertrand Joseph; Sten Orrenius
Tumor radiosensitivity and apoptosis.
Experimental cell research 1999;248(1):10-7.
1999: C Köhler; A Gahm; T Noma; A Nakazawa; Sten Orrenius; Boris Zhivotovsky
Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis.
FEBS letters 1999;447(1):10-2.
1999: D H Burgess; M Svensson; Tiziana Dandrea; K Grönlund; F Hammarquist; Sten Orrenius; Ian A Cotgreave
Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1.
Cell death and differentiation 1999;6(3):256-61.
1999: Adrienne M Gorman; E Bonfoco; Boris Zhivotovsky; Sten Orrenius; Sandra Ceccatelli
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells.
The European journal of neuroscience 1999;11(3):1067-72.
1999: Afshin Samali; H Nordgren; Boris Zhivotovsky; E Peterson; Sten Orrenius
A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis.
Biochemical and biophysical research communications 1999;255(1):6-11.
1998: Mark Hampton; Sten Orrenius
Redox regulation of apoptotic cell death in the immune system.
Toxicology letters 1998;102-103():355-8.
1998: Bengt Fadeel; Anders Ahlin; Jan-Inge Henter; Sten Orrenius; Mark Hampton
Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species.
Blood 1998;92(12):4808-18.
1998: M I Pörn-Ares; Afshin Samali; Sten Orrenius
Cleavage of the calpain inhibitor, calpastatin, during apoptosis.
Cell death and differentiation 1998;5(12):1028-33.
1998: Afshin Samali; Sten Orrenius
Heat shock proteins: regulators of stress response and apoptosis.
Cell stress & chaperones 1998;3(4):228-36.
1998: Mark Hampton; Bengt Fadeel; Sten Orrenius
Redox regulation of the caspases during apoptosis.
Annals of the New York Academy of Sciences 1998;854():328-35.
1998: M I Pörn-Ares; M P Ares; Sten Orrenius
Calcium signalling and the regulation of apoptosis.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(5):539-43.
1998: Afshin Samali; Boris Zhivotovsky; Dean P Jones; Sten Orrenius
Detection of pro-caspase-3 in cytosol and mitochondria of various tissues.
FEBS letters 1998;431(2):167-9.
1998: Adrienne M Gorman; Sten Orrenius; Sandra Ceccatelli
Apoptosis in neuronal cells: role of caspases.
Neuroreport 1998;9(10):R49-55.
1998: Helene Stridh; M Kimland; Dean P Jones; Sten Orrenius; Mark Hampton
Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis.
FEBS letters 1998;429(3):351-5.
1998: Mark J Burkitt; H S Bishop; L Milne; S Y Tsang; GJ Provan; stefan nobel; Sten Orrenius; AF Slater
Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species.
Archives of biochemistry and biophysics 1998;353(1):73-84.
1998: Mark Hampton; Boris Zhivotovsky; AF Slater; DH Burgess; Sten Orrenius
Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts.
The Biochemical journal 1998;329 ( Pt 1)():95-9.
1997: stefan nobel; M Kimland; D W Nicholson; Sten Orrenius; AF Slater
Disulfiram is a potent inhibitor of proteases of the caspase family.
Chemical research in toxicology 1997;10(12):1319-24.
1997: DM Vanags; Sten Orrenius; M Aguilar-Santelises
Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis.
British journal of haematology 1997;99(4):824-31.
1997: Mark Hampton; Sten Orrenius
Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis.
FEBS letters 1997;414(3):552-6.
1997: M I Pörn-Ares; S C Chow; J P Slotte; Sten Orrenius
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
Experimental cell research 1997;235(1):48-54.
1997: DM Vanags; Pontus Forsell; Stina Feltenmark; P J Jakobsson; Sten Orrenius; Hans-Erik Claesson; M Aguilar-Santelises
Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells.
Cell death and differentiation 1997;4(6):479-86.
1997: Sten Orrenius; DH Burgess; Mark Hampton; Boris Zhivotovsky
Mitochondria as the focus of apoptosis research.
Cell death and differentiation 1997;4(6):427-8.
1997: stefan nobel; DH Burgess; Boris Zhivotovsky; Mark J Burkitt; Sten Orrenius; AF Slater
Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme.
Chemical research in toxicology 1997;10(6):636-43.
1997: S C Chow; R Snowden; Sten Orrenius; G M Cohen
Susceptibility of different subsets of immature thymocytes to apoptosis.
FEBS letters 1997;408(2):141-6.
1997: A D Rossi; B Viviani; Boris Zhivotovsky; L Manzo; Sten Orrenius; M Vahter; P Nicotera
Inorganic mercury modifies Ca2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons.
Cell death and differentiation 1997;4(4):317-24.
1997: Boris Zhivotovsky; A Gahm; Sten Orrenius
Two different proteases are involved in the proteolysis of lamin during apoptosis.
Biochemical and biophysical research communications 1997;233(1):96-101.
1997: J Bustamante; L Dock; Marie Vahter; Bruce A Fowler; Sten Orrenius
The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes.
Toxicology 1997;118(2-3):129-36.
1997: Boris Zhivotovsky; DH Burgess; DM Vanags; Sten Orrenius
Involvement of cellular proteolytic machinery in apoptosis.
Biochemical and biophysical research communications 1997;230(3):481-8.
1997: S Jiang; Boris Zhivotovsky; DH Burgess; A Gahm; S C Chow; Sten Orrenius
The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+.
Cell death and differentiation 1997;4(1):39-50.
1997: D J van den Dobbelsteen; stefan nobel; AF Slater; Sten Orrenius
Regulation and mechanisms of apoptosis in T lymphocytes.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():77-85.
1997: Boris Zhivotovsky; D H Burgess; J Schlegel; M I Pörn; DM Vanags; Sten Orrenius
Proteases in Fas-mediated apoptosis.
Journal of cellular biochemistry 1997;64(1):43-9.
1997: Pierluigi Nicotera; M Ankarcrona; E Bonfoco; Sten Orrenius; S A Lipton
Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.
Advances in neurology 1997;72():95-101.
1996: E Bonfoco; B Zhivotovsky; A D Rossi; M Aguilar-Santelises; Sten Orrenius; S A Lipton; Pierluigi Nicotera
BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells.
Neuroreport 1996;8(1):273-6.
1996: Mark Hampton; DM Vanags; M I Pörn-Ares; Sten Orrenius
Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis.
FEBS letters 1996;399(3):277-82.
1996: DM Vanags; M I Pörn-Ares; S Coppola; DH Burgess; Sten Orrenius
Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis.
The Journal of biological chemistry 1996;271(49):31075-85.
1996: E Bonfoco; M Leist; B Zhivotovsky; Sten Orrenius; S A Lipton; Pierluigi Nicotera
Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation.
Journal of neurochemistry 1996;67(6):2484-93.
1996: M Ankarcrona; B Zhivotovsky; T Holmström; A Diana; John E Eriksson; Sten Orrenius; Pierluigi Nicotera
Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis.
Neuroreport 1996;7(15-17):2659-64.
1996: Sten Orrenius; stefan nobel; D J van den Dobbelsteen; Mark J Burkitt; AF Slater
Dithiocarbamates and the redox regulation of cell death.
Biochemical Society transactions 1996;24(4):1032-8.
1996: B Zhivotovsky; DH Burgess; Sten Orrenius
Proteases in apoptosis.
Experientia 1996;52(10-11):968-78.
1996: M Ankarcrona; J M Dypbukt; Sten Orrenius; Pierluigi Nicotera
Calcineurin and mitochondrial function in glutamate-induced neuronal cell death.
FEBS letters 1996;394(3):321-4.
1996: G E Kass; John E Eriksson; M Weis; Sten Orrenius; Sek C Chow
Chromatin condensation during apoptosis requires ATP.
The Biochemical journal 1996;318 ( Pt 3)():749-52.
1996: D J van den Dobbelsteen; stefan nobel; J Schlegel; I A Cotgreave; Sten Orrenius; AF Slater
Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody.
The Journal of biological chemistry 1996;271(26):15420-7.
1996: J Schlegel; I Peters; Sten Orrenius; D K Miller; Nancy A Thornberry; T T Yamin; Donald W Nicholson
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis.
The Journal of biological chemistry 1996;271(4):1841-4.
1996: AF Slater; C Stefan; I Nobel; D J van den Dobbelsteen; Sten Orrenius
Intracellular redox changes during apoptosis.
Cell death and differentiation 1996;3(1):57-62.
1996: Sten Orrenius; M Ankarcrona; Pierluigi Nicotera
Mechanisms of calcium-related cell death.
Advances in neurology 1996;71():137-49; discussion 149-51.
1996: Mark J Burkitt; L Milne; Pierluigi Nicotera; Sten Orrenius
1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.
The Biochemical journal 1996;313 ( Pt 1)():163-9.
1995: AF Slater; M Kimland; S A Jiang; Sten Orrenius
Constitutive nuclear NF kappa B/rel DNA-binding activity of rat thymocytes is increased by stimuli that promote apoptosis, but not inhibited by pyrrolidine dithiocarbamate.
The Biochemical journal 1995;312 ( Pt 3)():833-8.
1995: AF Slater; C Stefan; I Nobel; D J van den Dobbelsteen; Sten Orrenius
Signalling mechanisms and oxidative stress in apoptosis.
Toxicology letters 1995;82-83():149-53.
1995: B Zhivotovsky; A Gahm; M Ankarcrona; Pierluigi Nicotera; Sten Orrenius
Multiple proteases are involved in thymocyte apoptosis.
Experimental cell research 1995;221(2):404-12.
1995: stefan nobel; M Kimland; B Lind; Sten Orrenius; AF Slater
Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper.
The Journal of biological chemistry 1995;270(44):26202-8.
1995: J Bustamante; AF Slater; Sten Orrenius
Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid.
Free radical biology & medicine 1995;19(3):339-47.
1995: A Håkansson; B Zhivotovsky; Sten Orrenius; H Sabharwal; Catharina Svanborg
Apoptosis induced by a human milk protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8064-8.
1995: M Weis; J Schlegel; G E Kass; T H Holmström; I Peters; J Eriksson; Sten Orrenius; Sek C Chow
Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes.
Experimental cell research 1995;219(2):699-708.
1995: S Jiang; Sek C Chow; M J McCabe; Sten Orrenius
Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.
Laboratory investigation; a journal of technical methods and pathology 1995;73(1):111-7.
1995: AF Slater; stefan nobel; Sten Orrenius
The role of intracellular oxidants in apoptosis.
Biochimica et biophysica acta 1995;1271(1):59-62.
1995: J Schlegel; I Peters; Sten Orrenius
Isolation and partial characterization of a protease involved in Fas-induced apoptosis.
FEBS letters 1995;364(2):139-42.
1995: Sek C Chow; M Weis; G E Kass; T H Holmström; John E Eriksson; Sten Orrenius
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes.
FEBS letters 1995;364(2):134-8.
1995: AF Slater; stefan nobel; E Maellaro; J Bustamante; M Kimland; Sten Orrenius
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis.
The Biochemical journal 1995;306 ( Pt 3)():771-8.
1995: Sek C Chow; I Peters; Sten Orrenius
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis.
Experimental cell research 1995;216(1):149-59.
1994: J M Dypbukt; M Ankarcrona; Mark J Burkitt; A Sjöholm; K Ström; Sten Orrenius; Pierluigi Nicotera
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.
The Journal of biological chemistry 1994;269(48):30553-60.
1994: B Zhivotovsky; David Wade; Pierluigi Nicotera; Sten Orrenius
Role of nucleases in apoptosis.
International archives of allergy and immunology 1994;105(4):333-8.
1994: P Nicotera; B Zhivotovsky; Sten Orrenius
Nuclear calcium transport and the role of calcium in apoptosis.
Cell calcium 1994;16(4):279-88.
1994: G E Kass; Sek C Chow; A Gahm; D L Webb; Per-Olof Berggren; J Llopis; Sten Orrenius
Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes.
Biochimica et biophysica acta 1994;1223(2):226-33.
1994: B Zhivotovsky; David Wade; A Gahm; Sten Orrenius; Pierluigi Nicotera
Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation.
FEBS letters 1994;351(2):150-4.
1994: B Zhivotovsky; B Cedervall; S Jiang; Pierluigi Nicotera; Sten Orrenius
Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis.
Biochemical and biophysical research communications 1994;202(1):120-7.
1994: Sek C Chow; Sten Orrenius
Rapid cytoskeleton modification in thymocytes induced by the immunotoxicant tributyltin.
Toxicology and applied pharmacology 1994;127(1):19-26.
1994: M Weis; G E Kass; Sten Orrenius
Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants.
Biochemical pharmacology 1994;47(12):2147-56.
1994: S Jiang; Sek C Chow; Pierluigi Nicotera; Sten Orrenius
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin.
Experimental cell research 1994;212(1):84-92.
1993: A D Rossi; O Larsson; L Manzo; Sten Orrenius; M Vahter; Per-Olof Berggren; Pierluigi Nicotera
Modifications of Ca2+ signaling by inorganic mercury in PC12 cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(15):1507-14.
1993: M J McCabe; Sten Orrenius
Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.
Biochemical and biophysical research communications 1993;194(2):944-50.
1993: Sek C Chow; G E Kass; Sten Orrenius
Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation.
The Biochemical journal 1993;293 ( Pt 2)():395-8.
1993: B Zhivotovsky; Pierluigi Nicotera; G Bellomo; K Hanson; Sten Orrenius
Ca2+ and endonuclease activation in radiation-induced lymphoid cell death.
Experimental cell research 1993;207(1):163-70.
1993: M J McCabe; S A Jiang; Sten Orrenius
Chelation of intracellular zinc triggers apoptosis in mature thymocytes.
Laboratory investigation; a journal of technical methods and pathology 1993;69(1):101-10.
1993: L Milne; Pierluigi Nicotera; Sten Orrenius; Mark J Burkitt
Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione.
Archives of biochemistry and biophysics 1993;304(1):102-9.
1993: J Llopis; G C Farrell; S K Duddy; G E Kass; A Gahm; Sten Orrenius
Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver.
Biochemical pharmacology 1993;45(11):2209-14.
1993: D J McConkey; Sten Orrenius; S Okret; Mikael Jondal
Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(6):580-5.
1992: Pierluigi Nicotera; J M Dypbukt; A D Rossi; L Manzo; Sten Orrenius
Thiol modification and cell signalling in chemical toxicity.
Toxicology letters 1992;64-65 Spec No():563-7.
1992: Sten Orrenius; M J McCabe; Pierluigi Nicotera
Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death.
Toxicology letters 1992;64-65 Spec No():357-64.
1992: M J McCabe; Pierluigi Nicotera; Sten Orrenius
Calcium-dependent cell death. Role of the endonuclease, protein kinase C, and chromatin conformation.
Annals of the New York Academy of Sciences 1992;663():269-78.
1992: G E Kass; M J Juedes; Sten Orrenius
Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity.
Biochemical pharmacology 1992;44(10):1995-2003.
1992: M J Juedes; G E Kass; Sten Orrenius
m-iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes.
FEBS letters 1992;313(1):39-42.
1992: Sek C Chow; G E Kass; M J McCabe; Sten Orrenius
Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux.
Archives of biochemistry and biophysics 1992;298(1):143-9.
1992: J Llopis; G E Kass; A Gahm; Sten Orrenius
Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes.
The Biochemical journal 1992;284 ( Pt 1)():243-7.
1992: Pierluigi Nicotera; Sten Orrenius
Ca2+ and cell death.
Annals of the New York Academy of Sciences 1992;648():17-27.
1992: J M Dypbukt; L G Costa; L Manzo; Sten Orrenius; Pierluigi Nicotera
Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells.
Carcinogenesis 1992;13(3):417-24.
1992: M Weis; G E Kass; Sten Orrenius; P Moldéus
N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.
The Journal of biological chemistry 1992;267(2):804-9.
1992: Sten Orrenius; Mark J Burkitt; G E Kass; J M Dypbukt; Pierluigi Nicotera
Calcium ions and oxidative cell injury.
Annals of neurology 1992;32 Suppl():S33-42.
1991: B Brüne; P Hartzell; Pierluigi Nicotera; Sten Orrenius
Spermine prevents endonuclease activation and apoptosis in thymocytes.
Experimental cell research 1991;195(2):323-9.
1991: J Llopis; S B Chow; G E Kass; A Gahm; Sten Orrenius
Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes.
The Biochemical journal 1991;277 ( Pt 2)():553-6.
1991: J Llopis; G E Kass; S K Duddy; G C Farell; A Gahm; Sten Orrenius
Mobilization of the hormone-sensitive calcium pool increases hepatocyte tight junctional permeability in the perfused rat liver.
FEBS letters 1991;280(1):84-6.
1991: D J McConkey; Miguel Aguilar-Santelises; P Hartzell; I Eriksson; Håkan Mellstedt; Sten Orrenius; Mikael Jondal
Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):1072-6.
1991: Sten Orrenius; D J McConkey; Pierluigi Nicotera
Role of calcium in toxic and programmed cell death.
Advances in experimental medicine and biology 1991;283():419-25.
1990: T Y Aw; Pierluigi Nicotera; L Manzo; Sten Orrenius
Tributyltin stimulates apoptosis in rat thymocytes.
Archives of biochemistry and biophysics 1990;283(1):46-50.
1990: Pierluigi Nicotera; G Bellomo; Sten Orrenius
The role of Ca2+ in cell killing.
Chemical research in toxicology 1990;3(6):484-94.
1990: G E Kass; J Llopis; Sek C Chow; S K Duddy; Sten Orrenius
Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.
The Journal of biological chemistry 1990;265(29):17486-92.
1990: Pierluigi Nicotera; Sten Orrenius; T Nilsson; Per-Olof Berggren
An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6858-62.
1990: D J McConkey; Sten Orrenius; Mikael Jondal
Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1227-30.
1990: D J McConkey; Sek C Chow; Sten Orrenius; Mikael Jondal
NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(9):2661-4.
1990: G C Farrell; S K Duddy; G E Kass; J Llopis; A Gahm; Sten Orrenius
Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver.
The Journal of clinical investigation 1990;85(4):1255-9.
1990: D J McConkey; P Hartzell; Sten Orrenius
Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis.
Archives of biochemistry and biophysics 1990;278(1):284-7.
1990: D J McConkey; P Hartzell; Sek C Chow; Sten Orrenius; Mikael Jondal
Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.
The Journal of biological chemistry 1990;265(6):3009-11.
1990: G A Moore; G E Kass; S K Duddy; G C Farrell; J Llopis; Sten Orrenius
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel mobilizer of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
Free radical research communications 1990;8(4-6):337-45.
1989: S K Duddy; G E Kass; Sten Orrenius
Ca2(+)-mobilizing hormones stimulate Ca2+ efflux from hepatocytes.
The Journal of biological chemistry 1989;264(35):20863-6.
1989: G E Kass; S K Duddy; G A Moore; Sten Orrenius
2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
The Journal of biological chemistry 1989;264(26):15192-8.
1989: D J McConkey; P Hartzell; J F Amador-Pérez; Sten Orrenius; Mikael Jondal
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(6):1801-6.
1989: D J McConkey; P Hartzell; Mikael Jondal; Sten Orrenius
Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.
The Journal of biological chemistry 1989;264(23):13399-402.
1989: G E Kass; S K Duddy; Sten Orrenius
Activation of hepatocyte protein kinase C by redox-cycling quinones.
The Biochemical journal 1989;260(2):499-507.
1989: D J McConkey; Sten Orrenius
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo.
Biochemical and biophysical research communications 1989;160(3):1003-8.
1989: D J McConkey; P Hartzell; Pierluigi Nicotera; Sten Orrenius
Calcium-activated DNA fragmentation kills immature thymocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(7):1843-9.
1989: Dean P Jones; D J McConkey; Pierluigi Nicotera; Sten Orrenius
Calcium-activated DNA fragmentation in rat liver nuclei.
The Journal of biological chemistry 1989;264(11):6398-403.
1989: D J McConkey; Pierluigi Nicotera; P Hartzell; G Bellomo; A H Wyllie; Sten Orrenius
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.
Archives of biochemistry and biophysics 1989;269(1):365-70.
1989: Pierluigi Nicotera; D J McConkey; Dean P Jones; Sten Orrenius
ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):453-7.
1989: Pierluigi Nicotera; H Thor; Sten Orrenius
Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(1):59-64.
1989: Pierluigi Nicotera; D J McConkey; J M Dypbukt; Dean P Jones; Sten Orrenius
Ca2+-activated mechanisms in cell killing.
Drug metabolism reviews 1989;20(2-4):193-201.
1989: Pierluigi Nicotera; M Rundgren; D J Porubek; Ian A Cotgreave; P Moldéus; Sten Orrenius; S D Nelson
On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes.
Chemical research in toxicology 1989;2(1):46-50.
1988: G A Moore; M Weis; Sten Orrenius; P J O'Brien
Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria.
Archives of biochemistry and biophysics 1988;267(2):539-50.
1988: Pierluigi Nicotera; D McConkey; S A Svensson; G Bellomo; Sten Orrenius
Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress.
Toxicology 1988;52(1-2):55-63.
1988: D J McConkey; P Hartzell; S K Duddy; H Håkansson; Sten Orrenius
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
Science (New York, N.Y.) 1988;242(4876):256-9.
1988: D J McConkey; P Hartzell; Pierluigi Nicotera; A H Wyllie; Sten Orrenius
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.
Toxicology letters 1988;42(2):123-30.
1988: G E Kass; J M Wright; Pierluigi Nicotera; Sten Orrenius
The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
Archives of biochemistry and biophysics 1988;260(2):789-97.
1987: G A Moore; Luisa Rossi; Pierluigi Nicotera; Sten Orrenius; P J O'Brien
Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives.
Archives of biochemistry and biophysics 1987;259(2):283-95.
1987: G A Moore; D J McConkey; G E Kass; P J O'Brien; Sten Orrenius
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration.
FEBS letters 1987;224(2):331-6.
1987: Sten Orrenius; Pierluigi Nicotera
Biochemical mechanisms of oxidative liver cell injury.
Bulletin européen de physiopathologie respiratoire 1987;23(4):291-5.
1986: F Mirabelli; G Bellomo; Pierluigi Nicotera; M Moore; Sten Orrenius
Ca2+ homeostasis and cytotoxicity in isolated hepatocytes: studies with extracellular adenosine 5'-triphosphate.
Journal of biochemical toxicology 1986;1(1):29-39.
1986: L Eklöw-Låstbom; Luisa Rossi; H Thor; Sten Orrenius
Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.
Free radical research communications 1986;2(1-2):57-68.
1973: D L Cinti; R Grundin; Sten Orrenius
The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction.
The Biochemical journal 1973;134(2):367-75.