John Ortaldo

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Subleski Jeff J; Ortaldo John R
Editorial: NKT cells: to suppress or not to suppress, that is the question.
Winkler-Pickett Robin; Young Howard A; Cherry James M; Diehl John; Wine John; Back Timothy; Bere William E; Mason Anna T; Ortaldo John R
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses.
Ortaldo John R; Mason Anna; Willette-Brown Jami; Ruscetti Frank W; Wine John; Back Timothy; Stull Terri; Bere E William; Feigenbaum Lionel; Winkler-Pickett Robin; Young Howard A
Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.

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All Publications

2009: Subleski Jeff J; Ortaldo John R
Editorial: NKT cells: to suppress or not to suppress, that is the question.
Journal of leukocyte biology 2009;86(4):751-2.
2008: Winkler-Pickett Robin; Young Howard A; Cherry James M; Diehl John; Wine John; Back Timothy; Bere William E; Mason Anna T; Ortaldo John R
In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4495-506.
2007: Ortaldo John R; Mason Anna; Willette-Brown Jami; Ruscetti Frank W; Wine John; Back Timothy; Stull Terri; Bere E William; Feigenbaum Lionel; Winkler-Pickett Robin; Young Howard A
Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.
Cellular immunology 2007;249(1):8-19.
2006: Subleski Jeff J; Hall Veronica L; Back Timothy C; Ortaldo John R; Wiltrout Robert H
Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver.
Cancer research 2006;66(22):11005-12.
2006: Abdool Karen; Cretney Erika; Brooks Alan D; Kelly Janice M; Swann Jeremy; Shanker Anil; Bere Earl W; Yokoyama Wayne M; Ortaldo John R; Smyth Mark J; Sayers Thomas J
NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2575-83.
2006: Chen Xin; Oppenheim Joost J; Winkler-Pickett Robin T; Ortaldo John R; Howard O M Zack
Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE.
European journal of immunology 2006;36(8):2139-49.
2006: Ortaldo John R; Young Howard A
IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes.
Seminars in immunology 2006;18(3):193-6.
2006: Chen Xin; Winkler-Pickett Robin T; Carbonetti Nicholas H; Ortaldo John R; Oppenheim Joost J; Howard O M Zack
Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.
European journal of immunology 2006;36(3):671-80.
2006: Ortaldo John R; Winkler-Pickett Robin; Wigginton Jon; Horner Meagan; Bere Earl W; Mason Anna T; Bhat Narayan; Cherry James; Sanford Michael; Hodge Deborah L; Young Howard A
Regulation of ITAM-positive receptors: role of IL-12 and IL-18.
Blood 2006;107(4):1468-75.
2005: Ortaldo John R; Winkler-Pickett Robin T; Bere Earl W; Watanabe Morihiro; Murphy William J; Wiltrout Robert H
In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):693-9.
2005: Brehm Michael A; Daniels Keith A; Ortaldo John R; Welsh Raymond M
Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6663-71.
2005: Ortaldo John R; Young Howard A
Mouse Ly49 NK receptors: balancing activation and inhibition.
Molecular immunology 2005;42(4):445-50.
2004: Zhang Xia; Rodriguez-Galán Maria Cecilia; Subleski Jeff J; Ortaldo John R; Hodge Deborah L; Wang Ji-Ming; Shimozato Osamu; Reynolds Della A; Young Howard A
Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.
Blood 2004;104(10):3276-84.
2004: Albright Julia W; Bream Jay H; Bere Earl W; Young Howard A; Winkler-Pickett Robin; Ortaldo John R
Aging of innate immunity: functional comparisons of NK/LAK cells obtained from bulk cultures of young and aged mouse spleen cells in high concentrations of interleukin-2.
Experimental gerontology 2004;39(1):73-82.
2004: Ortaldo John R; Young Howard A; Winkler-Pickett Robin T; Bere Earl W; Murphy William J; Wiltrout Robert H
Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):943-53.
2003: Koh Crystal Y; Ortaldo John R; Blazar Bruce R; Bennett Michael; Murphy William J
NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade.
Blood 2003;102(12):4067-75.
2003: Mason Llewellyn H; Willette-Brown Jami; Anderson Stephen K; Alvord W Gregory; Klabansky Richard L; Young Howard A; Ortaldo John R
Receptor glycosylation regulates Ly-49 binding to MHC class I.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4235-42.
2003: Ortaldo John R; Young Howard A
Expression of IFN-gamma upon triggering of activating Ly49D NK receptors in vitro and in vivo: costimulation with IL-12 or IL-18 overrides inhibitory receptors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1763-9.
2002: Raziuddin Arati; Longo Dan L; Bennett Michael; Winkler-Pickett Robin; Ortaldo John R; Murphy William J
Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens.
Blood 2002;100(8):3026-33.
2002: McVicar Daniel W; Winkler-Pickett Robin; Taylor Lynn S; Makrigiannis Andrew; Bennett Michael; Anderson Stephen K; Ortaldo John R
Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1721-8.
2002: Hodge Deborah L; Schill William B; Wang Ji Ming; Blanca Isaac; Reynolds Della A; Ortaldo John R; Young Howard A
IL-2 and IL-12 alter NK cell responsiveness to IFN-gamma-inducible protein 10 by down-regulating CXCR3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6090-8.
2002: Colucci Francesco; Schweighoffer Edina; Tomasello Elena; Turner Martin; Ortaldo John R; Vivier Eric; Tybulewicz Victor L J; Di Santo James P
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.
Nature immunology 2002;3(3):288-94.
2002: Shimozato Osamu; Ortaldo John R; Komschlies Kristin L; Young Howard A
Impaired NK cell development in an IFN-gamma transgenic mouse: aberrantly expressed IFN-gamma enhances hematopoietic stem cell apoptosis and affects NK cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1746-52.
2001: Blanca I R; Bere E W; Young H A; Ortaldo J R
Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6132-9.
2001: Anderson S K; Ortaldo J R; McVicar D W
The ever-expanding Ly49 gene family: repertoire and signaling.
Immunological reviews 2001;181():79-89.
2001: Makrigiannis A P; Pau A T; Saleh A; Winkler-Pickett R; Ortaldo J R; Anderson S K
Class I MHC-binding characteristics of the 129/J Ly49 repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5034-43.
2001: Ortaldo J R; Bere E W; Hodge D; Young H A
Activating Ly-49 NK receptors: central role in cytokine and chemokine production.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4994-9.
2000: Makrigiannis A P; Etzler J; Winkler-Pickett R; Mason A; Ortaldo J R; Anderson S K
Identification of the Ly49L protein: evidence for activating counterparts to inhibitory Ly49 proteins.
Journal of leukocyte biology 2000;68(5):765-71.
2000: Ortaldo J R; Winkler-Pickett R; Wiegand G
Activating Ly-49D NK receptors: expression and function in relation to ontogeny and Ly-49 inhibitor receptors.
Journal of leukocyte biology 2000;68(5):748-56.
2000: Tomasello E; Desmoulins P O; Chemin K; Guia S; Cremer H; Ortaldo J; Love P; Kaiserlian D; Vivier E
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
Immunity 2000;13(3):355-64.
2000: Peacock C D; Lin M Y; Ortaldo J R; Welsh R M
The virus-specific and allospecific cytotoxic T-lymphocyte response to lymphocytic choriomeningitis virus is modified in a subpopulation of CD8(+) T cells coexpressing the inhibitory major histocompatibility complex class I receptor Ly49G2.
Journal of virology 2000;74(15):7032-8.
2000: Hoshino T; Yagita H; Ortaldo J R; Wiltrout R H; Young H A
In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells.
European journal of immunology 2000;30(7):1998-2006.
2000: Raziuddin A; Bennett M; Winkler-Pickett R; Ortaldo J R; Longo D L; Murphy W J
Synergistic effects of in vivo depletion of Ly-49A and Ly-49G2 natural killer cell subsets in the rejection of H2(b) bone marrow cell allografts.
Blood 2000;95(12):3840-4.
2000: Bosco M C; Curiel R E; Zea A H; Malabarba M G; Ortaldo J R; Espinoza-Delgado I
IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4575-85.
2000: Mason L H; Willette-Brown J; Mason A T; McVicar D; Ortaldo J R
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):603-11.
1999: Ortaldo J R; Winkler-Pickett R; Willette-Brown J; Wange R L; Anderson S K; Palumbo G J; Mason L H; McVicar D W
Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5269-77.
1999: Makrigiannis A P; Gosselin P; Mason L H; Taylor L S; McVicar D W; Ortaldo J R; Anderson S K
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4931-8.
1999: Ortaldo J R; Mason A T; Winkler-Pickett R; Raziuddin A; Murphy W J; Mason L H
Ly-49 receptor expression and functional analysis in multiple mouse strains.
Journal of leukocyte biology 1999;66(3):512-20.
1999: George T C; Ortaldo J R; Lemieux S; Kumar V; Bennett M
Tolerance and alloreactivity of the Ly49D subset of murine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1859-67.
1999: Gosselin P; Mason L H; Willette-Brown J; Ortaldo J R; McVicar D W; Anderson S K
Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H.
Journal of leukocyte biology 1999;66(1):165-71.
1999: Idris A H; Smith H R; Mason L H; Ortaldo J R; Scalzo A A; Yokoyama W M
The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6330-5.
1999: Yu C R; Ortaldo J R; Curiel R E; Young H A; Anderson S K; Gosselin P
Role of a STAT binding site in the regulation of the human perforin promoter.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2785-90.
1999: George T C; Mason L H; Ortaldo J R; Kumar V; Bennett M
Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2035-43.
1999: Nakamura M C; Linnemeyer P A; Niemi E C; Mason L H; Ortaldo J R; Ryan J C; Seaman W E
Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity.
The Journal of experimental medicine 1999;189(3):493-500.
1999: Tay C H; Yu L Y; Kumar V; Mason L; Ortaldo J R; Welsh R M
The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):718-26.
1999: Hoshino T; Winkler-Pickett R T; Mason A T; Ortaldo J R; Young H A
IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):51-9.
1998: Fogler W E; Volker K; Watanabe M; Wigginton J M; Roessler P; Brunda M J; Ortaldo J R; Wiltrout R H
Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6014-21.
1998: McVicar D W; Taylor L S; Gosselin P; Willette-Brown J; Mikhael A I; Geahlen R L; Nakamura M C; Linnemeyer P; Seaman W E; Anderson S K; Ortaldo J R; Mason L H
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
The Journal of biological chemistry 1998;273(49):32934-42.
1998: Vos Q; Ortaldo J R; Conan-Cibotti M; Vos M D; Young H A; Anderson S K; Witherspoon K; Prager I; Snapper C M; Mond J J
Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro.
International immunology 1998;10(8):1093-101.
1998: Yu C R; Young H A; Ortaldo J R
Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells.
Journal of leukocyte biology 1998;64(2):245-58.
1998: Yu C R; Kirken R A; Malabarba M G; Young H A; Ortaldo J R
Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):218-27.
1998: Mason L H; Willette-Brown J; Anderson S K; Gosselin P; Shores E W; Love P E; Ortaldo J R; McVicar D W
Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4148-52.
1998: Ortaldo J R; Winkler-Pickett R; Mason A T; Mason L H
The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1158-65.
1998: Raziuddin A; Longo D L; Mason L; Ortaldo J R; Bennett M; Murphy W J
Differential effects of the rejection of bone marrow allografts by the depletion of activating versus inhibiting Ly-49 natural killer cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):87-94.
1997: Mason L H; Gosselin P; Anderson S K; Fogler W E; Ortaldo J R; McVicar D W
Differential tyrosine phosphorylation of inhibitory versus activating Ly-49 receptor proteins and their recruitment of SHP-1 phosphatase.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4187-96.
1997: Ortaldo J R; Mason L H; Gregorio T A; Stoll J; Winkler-Pickett R T
The Ly-49 family: regulation of cytokine production in murine NK cells.
Journal of leukocyte biology 1997;62(3):381-8.
1997: Watanabe M; McCormick K L; Volker K; Ortaldo J R; Wigginton J M; Brunda M J; Wiltrout R H; Fogler W E
Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis.
The American journal of pathology 1997;150(5):1869-80.
1997: Bosco M C; Rottschafer S; Taylor L S; Ortaldo J R; Longo D L; Espinoza-Delgado I
The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: synergy with interleukin-2 and modulation of interleukin-2Rgamma chain expression.
Blood 1997;89(9):3402-11.
1997: Ortaldo J R; Winkler-Pickett R T; Nagata S; Ware C F
Fas involvement in human NK cell apoptosis: lack of a requirement for CD16-mediated events.
Journal of leukocyte biology 1997;61(2):209-15.
1997: Ortaldo J R; Mason A T; Mason L H; Winkler-Pickett R T; Gosselin P; Anderson S K
Selective inhibition of human and mouse natural killer tumor recognition using retroviral antisense in primary natural killer cells: involvement with MHC class I killer cell inhibitory receptors.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1262-7.
1997: Young H A; Klinman D M; Reynolds D A; Grzegorzewski K J; Nii A; Ward J M; Winkler-Pickett R T; Ortaldo J R; Kenny J J; Komschlies K L
Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies.
Blood 1997;89(2):583-95.
1997: Grgurevich S; Linnekin D; Musso T; Zhang X; Modi W; Varesio L; Ruscetti F W; Ortaldo J R; McVicar D W
The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e.
Growth factors (Chur, Switzerland) 1997;14(2-3):103-15.
1996: Mason L H; Anderson S K; Yokoyama W M; Smith H R; Winkler-Pickett R; Ortaldo J R
The Ly-49D receptor activates murine natural killer cells.
The Journal of experimental medicine 1996;184(6):2119-28.
1996: Ortaldo J R; Mason A T; Longo D L; Beckwith M; Creekmore S P; McVicar D W
T cell activation via the disialoganglioside GD3: analysis of signal transduction.
Journal of leukocyte biology 1996;60(4):533-9.
1996: Conlon K C; Anver M R; Longo D L; Ortaldo J R; Murphy W J
Adoptive immunotherapy involving recombinant human M-CSF and R24 anti-melanoma antibody induces human T-cell infiltration into human melanoma xenografts.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(5):317-23.
1996: Ye J; Cippitelli M; Dorman L; Ortaldo J R; Young H A
The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element.
Molecular and cellular biology 1996;16(9):4744-53.
1996: Fogler W E; Volker K; McCormick K L; Watanabe M; Ortaldo J R; Wiltrout R H
NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4707-14.
1996: McVicar D W; Blake T B; Burns C M; Conlon K C; Ortaldo J R; O'Shea J J
Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells: a biochemical correlate of lymphoid functional activity.
Cellular immunology 1996;169(2):302-8.
1996: Giardina S L; Coffman J D; Young H A; Potter S J; Frey J L; Ortaldo J R; Anderson S K
Association of the expression of an SR-cyclophilin with myeloid cell differentiation.
Blood 1996;87(6):2269-74.
1995: Tortolani P J; Lal B K; Riva A; Johnston J A; Chen Y Q; Reaman G H; Beckwith M; Longo D; Ortaldo J R; Bhatia K; McGrath I; Kehrl J; Tuscano J; McVicar D W; O'Shea J J
Regulation of JAK3 expression and activation in human B cells and B cell malignancies.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5220-6.
1995: Taub D D; Sayers T J; Carter C R; Ortaldo J R
Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3877-88.
1995: Johnston J A; Bacon C M; Finbloom D S; Rees R C; Kaplan D; Shibuya K; Ortaldo J R; Gupta S; Chen Y Q; Giri J D
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8705-9.
1995: Ye J; Ortaldo J R; Conlon K; Winkler-Pickett R; Young H A
Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line.
Journal of leukocyte biology 1995;58(2):225-33.
1995: Bacon C M; Petricoin E F; Ortaldo J R; Rees R C; Larner A C; Johnston J A; O'Shea J J
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7307-11.
1995: Mason A T; McVicar D W; Smith C A; Young H A; Ware C F; Ortaldo J R
Regulation of NK cells through the 80-kDa TNFR (CD120b).
Journal of leukocyte biology 1995;58(2):249-55.
1995: Ortaldo J R; Wiltrout T A; Sayers T J; Yagita H; Winkler-Pickett R T
Characterization of a non-granule associated pore-forming protein in agranular lymphocytes.
Journal of leukocyte biology 1995;57(6):897-903.
1995: Conlon K; Osborne J; Morimoto C; Ortaldo J R; Young H A
Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes.
European journal of immunology 1995;25(3):644-8.
1995: Giardina S L; Anderson S K; Sayers T J; Chambers W H; Palumbo G A; Young H A; Ortaldo J R
Selective loss of NK cytotoxicity in antisense NK-TR1 rat LGL cell lines. Abrogation of antibody-independent tumor and virus-infected target cell killing.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):80-7.
1995: Bacon C M; McVicar D W; Ortaldo J R; Rees R C; O'Shea J J; Johnston J A
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
The Journal of experimental medicine 1995;181(1):399-404.
1995: Ortaldo J R; Mason A T; O'Shea J J
Receptor-induced death in human natural killer cells: involvement of CD16.
The Journal of experimental medicine 1995;181(1):339-44.
1994: Musso T; Varesio L; Zhang X; Rowe T K; Ferrara P; Ortaldo J R; O'Shea J J; McVicar D W
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.
The Journal of experimental medicine 1994;180(6):2383-8.
1994: Ye J; Ghosh P; Cippitelli M; Subleski J; Hardy K J; Ortaldo J R; Young H A
Characterization of a silencer regulatory element in the human interferon-gamma promoter.
The Journal of biological chemistry 1994;269(41):25728-34.
1994: Mikovits J A; Meyers A M; Ortaldo J R; Minty A; Caput D; Ferrara P; Ruscetti F W
IL-4 and IL-13 have overlapping but distinct effects on HIV production in monocytes.
Journal of leukocyte biology 1994;56(3):340-6.
1994: Kawamura M; McVicar D W; Johnston J A; Blake T B; Chen Y Q; Lal B K; Lloyd A R; Kelvin D J; Staples J E; Ortaldo J R
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6374-8.
1994: Johnston J A; Kawamura M; Kirken R A; Chen Y Q; Blake T B; Shibuya K; Ortaldo J R; McVicar D W; O'Shea J J
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Nature 1994;370(6485):151-3.
1994: Kaneda K; Pilaro A M; Sayers T J; Nagashima K; Gonda M A; Ortaldo J R; Wiltrout R H
Quantitative analysis of rod-cored vesicles and dense granules of large granular lymphocytes in the liver, spleen, and peripheral blood of rats.
Cell and tissue research 1994;276(1):187-95.
1994: Chambers C A; Gallinger S; Anderson S K; Giardina S; Ortaldo J R; Hozumi N; Roder J
Expression of the NK-TR gene is required for NK-like activity in human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2669-74.
1994: Mason L H; Yagita H; Ortaldo J R
LGL-1: a potential triggering molecule on murine NK cells.
Journal of leukocyte biology 1994;55(3):362-70.
1994: McVicar D W; Mason A T; Bere E W; Ortaldo J R
Activation of peripheral large granular lymphocytes with the serine/threonine phosphatase inhibitor, okadaic acid.
European journal of immunology 1994;24(1):165-70.
1993: Murphy W J; Back T C; Conlon K C; Komschlies K L; Ortaldo J R; Sayers T J; Wiltrout R H; Longo D L
Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts.
The Journal of clinical investigation 1993;92(4):1918-24.
1993: Ortaldo J
Cell-mediated cytotoxicity. Summary of the 5th International Workshop. Neve Ilan, Israel.
European cytokine network 1993;4(5):383-4.
1993: Taub D D; Lloyd A R; Conlon K; Wang J M; Ortaldo J R; Harada A; Matsushima K; Kelvin D J; Oppenheim J J
Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells.
The Journal of experimental medicine 1993;177(6):1809-14.
1993: Young H A; Jenkins N A; Copeland N G; Simek S; Lerman M I; Zbar B; Glenn G; Ortaldo J R; Anderson S K
Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9.
Genomics 1993;16(2):548-9.
1993: Murphy W J; Conlon K C; Sayers T J; Wiltrout R H; Back T C; Ortaldo J R; Longo D L
Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3634-42.
1993: Anderson S K; Gallinger S; Roder J; Frey J; Young H A; Ortaldo J R
A cyclophilin-related protein involved in the function of natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):542-6.
1992: Ortaldo J R; Glenn G M; Young H A; Frey J L
Natural killer (NK) cell lytic dysfunction and putative NK cell receptor expression abnormality in members of a family with chromosome 3p-linked von Hippel-Lindau disease.
Journal of the National Cancer Institute 1992;84(24):1897-903.
1992: Ortaldo J R; Winkler-Pickett R T; Nagashima K; Yagita H; Okumura K
Direct evidence for release of pore-forming protein during NK cellular lysis.
Journal of leukocyte biology 1992;52(5):483-8.
1992: Conlon K C; Ochoa A C; Kopp W C; Ortaldo J R; Urba W J; Longo D L; Young H A
Enhanced lymphokine production and lymphokine receptor expression in multiple antibody-stimulated human CD4+ peripheral blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3278-89.
1992: Ortaldo J R; Winkler-Pickett R; Kopp W; Kawasaki A; Nagashima K; Okumura K; Yagita H; Bach F H
Relationship of large and small CD3- CD56+ lymphocytes mediating NK-associated activities.
Journal of leukocyte biology 1992;52(3):287-95.
1992: Bino T; Frey J L; Ortaldo J R
Mechanism of target cell recognition by CD3- LGL. I. Development of a monoclonal antibody to a K562-associated target cell antigen.
Cellular immunology 1992;142(1):28-39.
1992: O'Shea J J; McVicar D W; Kuhns D B; Ortaldo J R
A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(8):2497-502.
1992: Smyth M J; Norihisa Y; Ortaldo J R
Multiple cytolytic mechanisms displayed by activated human peripheral blood T cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):55-62.
1991: Smyth M J; Norihisa Y; Gerard J R; Young H A; Ortaldo J R
IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets.
Cellular immunology 1991;138(2):390-403.
1991: Futami H; Eader L A; Komschlies K L; Bull R; Gruys M E; Ortaldo J R; Young H A; Wiltrout R H
Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes.
Cancer research 1991;51(24):6596-602.
1991: Frey J L; Bino T; Kantor R R; Segal D M; Giardina S L; Roder J; Anderson S; Ortaldo J R
Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes.
The Journal of experimental medicine 1991;174(6):1527-36.
1991: Letourneur O; Kennedy I C; Brini A T; Ortaldo J R; O'Shea J J; Kinet J P
Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII).
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2652-6.
1991: Ortaldo J R; Winkler-Pickett R T; Yagita H; Young H A
Comparative studies of CD3- and CD3+ CD56+ cells: examination of morphology, functions, T cell receptor rearrangement, and pore-forming protein expression.
Cellular immunology 1991;136(2):486-95.
1991: Ortaldo J R
Human cytotoxic effector cells: definition and analysis of activity.
Allergologia et immunopathologia 1991;19(4):145-56.
1991: Winkler-Pickett R T; Young H A; Kuta A; Ortaldo J R
Analysis of rat natural killer cytotoxic factor (NKCF): mechanism of action and relationship to other cytotoxic/cytostatic factors.
Cellular immunology 1991;135(1):42-54.
1991: Ortaldo J R; Mason A T; O'Shea J J; Smyth M J; Falk L A; Kennedy I C; Longo D L; Ruscetti F W
Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3791-8.
1991: Smyth M J; Zachariae C O; Norihisa Y; Ortaldo J R; Hishinuma A; Matsushima K
IL-8 gene expression and production in human peripheral blood lymphocyte subsets.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):3815-23.
1991: Smyth M J; Strobl S L; Young H A; Ortaldo J R; Ochoa A C
Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3289-97.
1991: Smyth M J; Ortaldo J R
Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1380-4.
1991: Mason A; Bernard A; Smyth M J; Ortaldo J R
Role of CD2 in regulation of CD3- LGL function.
European cytokine network 1991;2(1):31-7.
1991: O'Shea J J; Weissman A M; Kennedy I C; Ortaldo J R
Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):350-4.
1990: Galli M C; Smyth M J; Young H A; Reynolds C W; Ortaldo J R
Differential regulation of interleukin-1 gene expression in human CD3- large granular lymphocytes.
Cellular immunology 1990;131(1):184-90.
1990: O'Shea J J; Ortaldo J R
Killer T's, macrophages, and NK's. The Fourth International Cell-Mediated Cytotoxicity Workshop, sponsored by the Pittsburgh CancerInstitute, and the University of Pittsburgh Medical Health Care Division, Oglebay Park, WV, USA, June 10-13, 1990.
The New biologist 1990;2(9):779-82.
1990: Smyth M J; Ortaldo J R; Bere W; Yagita H; Okumura K; Young H A
IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1159-66.
1990: Mason L H; Mathieson B J; Ortaldo J R
Natural killer (NK) cell subsets in the mouse. NK-1.1+/LGL-1+ cells restricted to lysing NK targets, whereas NK-1.1+/LGL-1- cells generate lymphokine-activated killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(2):751-9.
1990: Espinoza-Delgado I; Ortaldo J R; Winkler-Pickett R; Sugamura K; Varesio L; Longo D L
Expression and role of p75 interleukin 2 receptor on human monocytes.
The Journal of experimental medicine 1990;171(5):1821-6.
1990: Smyth M J; Ortaldo J R; Shinkai Y; Yagita H; Nakata M; Okumura K; Young H A
Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.
The Journal of experimental medicine 1990;171(4):1269-81.
1990: Ortaldo J R; Frey J; Takeshita T; Sugamura K
Regulation of CD3- lymphocyte function with an antibody against the IL-2 beta chain receptor: modulation of NK and LAK activity and production of IFN gamma.
European cytokine network 1990;1(1):27-34.
1989: Ortaldo J R; Hiserodt J C
Mechanisms of target cell killing by natural killer cells.
Current opinion in immunology 1989;2(1):39-42.
1989: Wiltrout R H; Pilaro A M; Gruys M E; Talmadge J E; Longo D L; Ortaldo J R; Reynolds C W
Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):372-8.
1989: Ortaldo J R; Young H A; Varesio L
Modulation of CD3- large granular lymphocyte functions by agonist and antagonists of protein kinase C: effects on NK and lymphokine-activated killer activity and production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):366-71.
1989: Sakamoto S; Ortaldo J R; Young H A
Analysis of the methylation state of the T cell receptor beta chain gene in T cells and large granular lymphocytes.
The Journal of biological chemistry 1989;264(1):251-8.
1988: Mason L; Giardina S L; Hecht T; Ortaldo J; Mathieson B J
LGL-1: a non-polymorphic antigen expressed on a major population of mouse natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4403-12.
1987: Ortaldo J R; Winkler-Pickett R; Morgan A C; Woodhouse C; Kantor R; Reynolds C W
Analysis of rat natural killer cytotoxic factor (NKCF) produced by rat NK cell lines and the production of a murine monoclonal antibody that neutralizes NKCF.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(9):3159-65.
1987: Ortaldo J R; Woodhouse C; Morgan A C; Herberman R B; Cheresh D A; Reisfeld R
Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(10):3566-72.
1986: Sayers T J; Ransom J H; Denn A C; Herberman R B; Ortaldo J R
Analysis of a cytostatic lymphokine produced by incubation of lymphocytes with tumor cells: relationship to leukoregulin and distinction from recombinant lymphotoxin, recombinant tumor necrosis factor, and natural killer cytotoxic factor.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):385-90.

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