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Juan Ortín

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Rocío Arranz; José L Carrascosa; Francisco Javier Chichón García; Rocío Coloma; José Javier Conesa; Juan Ortín; José M Valpuesta; Jaime Martín-Benito
The structure of native influenza virion ribonucleoproteins.
Sara Landeras-Bueno; Núria Jorba; Maite Pérez-Cidoncha; Juan Ortín
The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.
Rocío Coloma; José M Valpuesta; Rocío Arranz; José L Carrascosa; Juan Ortín; Jaime Martín-Benito
The structure of a biologically active influenza virus ribonucleoprotein complex.

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All Publications

2012: Rocío Arranz; José L Carrascosa; Francisco Javier Chichón García; Rocío Coloma; José Javier Conesa; Juan Ortín; José M Valpuesta; Jaime Martín-Benito
The structure of native influenza virion ribonucleoproteins.
Science (New York, N.Y.) 2012;338(6114):1634-7.
2011: Sara Landeras-Bueno; Núria Jorba; Maite Pérez-Cidoncha; Juan Ortín
The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.
PLoS pathogens 2011;7(11):e1002397.
2009: Rocío Coloma; José M Valpuesta; Rocío Arranz; José L Carrascosa; Juan Ortín; Jaime Martín-Benito
The structure of a biologically active influenza virus ribonucleoprotein complex.
PLoS pathogens 2009;5(6):e1000491.
2008: Ben Hale; Richard E Randall; Juan Ortín; David Jackson
The multifunctional NS1 protein of influenza A viruses.
The Journal of general virology 2008;89(Pt 10):2359-76.
2008: Núria Jorba; Silvia Juarez; Eva Torreira; Pablo Gastaminza; Noelia Zamarreño; Juan Pablo Albar; Juan Ortín
Analysis of the interaction of influenza virus polymerase complex with human cell factors.
Proteomics 2008;8(10):2077-88.
2008: Núria Jorba; Estela Area; Juan Ortín
Oligomerization of the influenza virus polymerase complex in vivo.
The Journal of general virology 2008;89(Pt 2):520-4.
2008: Patricia Resa-Infante; Núria Jorba; Noelia Zamarreño; Yolanda Fernández; Silvia Juárez; Juan Ortín
The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.
PloS one 2008;3(12):e3904.
2007: Eva Torreira; Guy Schoehn; Yolanda Fernández; Núria Jorba; Rob W H Ruigrok; Stephen Cusack; Juan Ortín; Oscar Llorca
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer.
Nucleic acids research 2007;35(11):3774-83.
2007: Urtzi Garaigorta; Juan Ortín
Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA.
Nucleic acids research 2007;35(14):4573-82.
2005: Urtzi Garaigorta; Ana M Falcón; Juan Ortín
Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.
Journal of virology 2005;79(24):15246-57.
2005: Ana M Falcón; Ana Fernandez-Sesma; Yurie Nakaya; Thomas M Moran; Juan Ortín; Adolfo García-Sastre
Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins.
The Journal of general virology 2005;86(Pt 10):2817-21.
2004: Ana M Falcón; Rosa M Marión; Thomas Zürcher; Paulino Gómez; Agustín Portela; Amelia Nieto; Juan Ortín
Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein.
Journal of virology 2004;78(8):3880-8.
2004: Estela Area; Jaime Martín-Benito; Pablo Gastaminza; Eva Torreira; José M Valpuesta; José L Carrascosa; Juan Ortín
3D structure of the influenza virus polymerase complex: localization of subunit domains.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):308-13.
2004: Patricia Villacé; Rosa M Marión; Juan Ortín
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Nucleic acids research 2004;32(8):2411-20.
2003: Idoia Burgui; Tomás Aragón; Juan Ortín; Amelia Nieto
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes.
The Journal of general virology 2003;84(Pt 12):3263-74.
2003: Maite Huarte; Ana M Falcón; Yuri Nakaya; Juan Ortín; Adolfo García-Sastre; Amelia Nieto
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses.
Journal of virology 2003;77(10):6007-13.
2003: Pablo Gastaminza; Beatriz Perales; Ana M Falcón; Juan Ortín
Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription.
Journal of virology 2003;77(9):5098-108.
2001: Maite Huarte; JJ Sanz-Ezquerro; F Roncal; Juan Ortín; Amelia Nieto
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators.
Journal of virology 2001;75(18):8597-604.
2001: Jaime Martín-Benito; E Area; J Ortega; Oscar Llorca; José M Valpuesta; José L Carrascosa; Juan Ortín
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle.
EMBO reports 2001;2(4):313-7.
2000: Thomas Zürcher; Rosa M Marión; Juan Ortín
Protein synthesis shut-off induced by influenza virus infection is independent of PKR activity.
Journal of virology 2000;74(18):8781-4.
2000: Tomás Aragón; S de la Luna; I Novoa; Luis Carrasco; Juan Ortín; Amelia Nieto
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.
Molecular and cellular biology 2000;20(17):6259-68.
2000: Beatriz Perales; JJ Sanz-Ezquerro; Pablo Gastaminza; J Ortega; J F Santarén; Juan Ortín; Amelia Nieto
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis.
Journal of virology 2000;74(3):1307-12.
2000: J Ortega; Jaime Martín-Benito; Thomas Zürcher; José M Valpuesta; José L Carrascosa; Juan Ortín
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification.
Journal of virology 2000;74(1):156-63.
1999: S González; Juan Ortín
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates.
The EMBO journal 1999;18(13):3767-75.
1999: Ana M Falcón; Puri Fortes; Rosa M Marión; A Beloso; Juan Ortín
Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro.
Nucleic acids research 1999;27(11):2241-7.
1999: Rosa M Marión; Puri Fortes; A Beloso; Carlos G Dotti; Juan Ortín
A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum.
Molecular and cellular biology 1999;19(3):2212-9.
1999: I Mena; E Jambrina; C Albo; Beatriz Perales; Juan Ortín; M Arrese; D Vallejo; Agustín Portela
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replication.
Journal of virology 1999;73(2):1186-94.
1999: Agustín Portela; Thomas Zürcher; Amelia Nieto; Juan Ortín
Replication of orthomyxoviruses.
Advances in virus research 1999;54():319-48.
1999: S González; Juan Ortín
Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain.
Journal of virology 1999;73(1):631-7.
1998: Friedemann Weber; E Jambrina; S González; JT Dessens; Michael B Leahy; Georg Kochs; Agustín Portela; Patricia A Nuttall; Otto Haller; Juan Ortín; Thomas Zürcher
In vivo reconstitution of active Thogoto virus polymerase: assays for the compatibility with other orthomyxovirus core proteins and template RNAs.
Virus research 1998;58(1-2):13-20.
1998: JJ Sanz-Ezquerro; J Fernández Santarén; T Sierra; Tomás Aragón; J Ortega; Juan Ortín; G L Smith; Amelia Nieto
The PA influenza virus polymerase subunit is a phosphorylated protein.
The Journal of general virology 1998;79 ( Pt 3)():471-8.
1997: Rosa M Marión; Tomás Aragón; A Beloso; Amelia Nieto; Juan Ortín
The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation.
Nucleic acids research 1997;25(21):4271-7.
1997: Rosa M Marión; Thomas Zürcher; S de la Luna; Juan Ortín
Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo.
The Journal of general virology 1997;78 ( Pt 10)():2447-51.
1997: I Novoa; Francisco Martinez-Abarca; Puri Fortes; Juan Ortín; Luis Carrasco
Cleavage of p220 by purified poliovirus 2A(pro) in cell-free systems: effects on translation of capped and uncapped mRNAs.
Biochemistry 1997;36(25):7802-9.
1997: Beatriz Perales; Juan Ortín
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA.
Journal of virology 1997;71(2):1381-5.
1996: S González; Thomas Zürcher; Juan Ortín
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure.
Nucleic acids research 1996;24(22):4456-63.
1996: Thomas Zürcher; S de la Luna; J J Sanz-Ezquerro; Amelia Nieto; Juan Ortín
Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant.
The Journal of general virology 1996;77 ( Pt 8)():1745-9.
1996: P Suárez; M Díaz-Guerra; Cinta Prieto; M Esteban; José M Castro; A Nieto; Juan Ortín
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Journal of virology 1996;70(5):2876-82.
1996: J J Sanz-Ezquerro; Thomas Zürcher; S de la Luna; Juan Ortín; Amelia Nieto
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis.
Journal of virology 1996;70(3):1905-11.
1996: Beatriz Perales; S de la Luna; I Palacios; Juan Ortín
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
Journal of virology 1996;70(3):1678-86.
1995: M Ochoa; J Bárcena; S de la Luna; José A Melero; A R Douglas; Amelia Nieto; Juan Ortín; J J Skehel; Agustín Portela
Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides.
Virus research 1995;37(3):305-15.
1995: Puri Fortes; A I Lamond; Juan Ortín
Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components.
The Journal of general virology 1995;76 ( Pt 4)():1001-7.
1995: S de la Luna; Puri Fortes; A Beloso; Juan Ortín
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs.
Journal of virology 1995;69(4):2427-33.
1995: J J Sanz-Ezquerro; S de la Luna; Juan Ortín; Amelia Nieto
Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.
Journal of virology 1995;69(4):2420-6.
1994: J Bárcena; M Ochoa; S de la Luna; José A Melero; Amelia Nieto; Juan Ortín; Agustín Portela
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro.
Journal of virology 1994;68(11):6900-9.
1994: I Mena; S de la Luna; C Albo; J Martín; Amelia Nieto; Juan Ortín; Agustín Portela
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
The Journal of general virology 1994;75 ( Pt 8)():2109-14.
1994: Puri Fortes; A Beloso; Juan Ortín
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.
The EMBO journal 1994;13(3):704-12.
1994: P Suárez-López; Juan Ortín
An estimation of the nucleotide substitution rate at defined positions in the influenza virus haemagglutinin gene.
The Journal of general virology 1994;75 ( Pt 2)():389-93.
1994: Amelia Nieto; S de la Luna; J Bárcena; Agustín Portela; Juan Ortín
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.
The Journal of general virology 1994;75 ( Pt 1)():29-36.
1993: J Valcárcel; Puri Fortes; Juan Ortín
Splicing of influenza virus matrix protein mRNA expressed from a simian virus 40 recombinant.
The Journal of general virology 1993;74 ( Pt 7)():1317-26.
1993: S de la Luna; J Martín; Agustín Portela; Juan Ortín
Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses.
The Journal of general virology 1993;74 ( Pt 3)():535-9.
1992: J Martín; C Albo; Juan Ortín; José A Melero; Agustín Portela
In vitro reconstitution of active influenza virus ribonucleoprotein complexes using viral proteins purified from infected cells.
The Journal of general virology 1992;73 ( Pt 7)():1855-9.
1992: Amelia Nieto; S de la Luna; J Bárcena; Agustín Portela; J Valcárcel; José A Melero; Juan Ortín
Nuclear transport of influenza virus polymerase PA protein.
Virus research 1992;24(1):65-75.
1992: P Suárez; J Valcárcel; Juan Ortín
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants.
Journal of virology 1992;66(4):2491-4.
1992: A Beloso; C Martínez; J Valcárcel; J F Santarén; Juan Ortín
Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoff.
The Journal of general virology 1992;73 ( Pt 3)():575-81.
1992: S de la Luna; Juan Ortín
pac gene as efficient dominant marker and reporter gene in mammalian cells.
Methods in enzymology 1992;216():376-85.
1991: J Valcárcel; Agustín Portela; Juan Ortín
Regulated M1 mRNA splicing in influenza virus-infected cells.
The Journal of general virology 1991;72 ( Pt 6)():1301-8.
1990: J A López-Turiso; C Martínez; T Tanaka; Juan Ortín
The synthesis of influenza virus negative-strand RNA takes place in insoluble complexes present in the nuclear matrix fraction.
Virus research 1990;16(3):325-37.
1989: C Martínez; S de la Luna; F Peláez; A Lopez-Turiso; J Valcárcel; César de Haro; Juan Ortín
Permanent cell lines that show temperature-dependent expression of adenovirus virus-associated RNA.
Journal of virology 1989;63(12):5445-50.
1989: J Valcárcel; Juan Ortín
Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus.
Journal of virology 1989;63(9):4107-9.
1989: S de la Luna; C Martínez; Juan Ortín
Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains.
Virus research 1989;13(2):143-55.
1988: J A López-Turiso; Juan Ortín
Transfection of MDCK cells with influenza virus ribonucleoprotein complexes.
Microbiología (Madrid, Spain) 1988;4(3):167-75.
1988: S de la Luna; I Soria; D Pulido; Juan Ortín; Antonio Jiménez
Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker.
Gene 1988;62(1):121-6.
1987: S de la Luna; Agustín Portela; C Martínez; Juan Ortín
Permanent cell lines established from ts-COS cells that regulate by temperature the amplification and expression of cloned genes.
Nucleic acids research 1987;15(15):6117-29.
1986: Agustín Portela; José A Melero; S de la Luna; Juan Ortín
Construction of cell lines that regulate by temperature the amplification and expression of influenza virus non-structural protein genes.
The EMBO journal 1986;5(9):2387-92.
1986: J A Vara; Agustín Portela; Juan Ortín; A Jiménez
Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance.
Nucleic acids research 1986;14(11):4617-24.
1986: Francisco Sobrino; Eduardo L Palma; E Beck; Mercedes Dávila; J C de la Torre; P Negro; N Villanueva; Juan Ortín; Esteban Domingo
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations.
Gene 1986;50(1-3):149-59.
1985: Agustín Portela; J A Melero; C Martínez; E Domingo; Juan Ortín
Oriented synthesis and cloning of influenza virus nucleoprotein cDNA that leads to its expression in mammalian cells.
Virus research 1985;4(1):69-82.
1985: Agustín Portela; S de la Luna; José A Melero; J Vara; A Jiménez; Juan Ortín
Regulation of gene amplification and expression in cells that constitutively express a temperature sensitive SV40 T-antigen.
Nucleic acids research 1985;13(22):7913-27.
1985: Agustín Portela; J A Melero; C Martínez; E Domingo; Juan Ortín
A primer vector system that allows temperature dependent gene amplification and expression in mammalian cells: regulation of the influenza virus NS1 gene expression.
Nucleic acids research 1985;13(22):7959-77.
1985: J C de la Torre; Mercedes Dávila; Francisco Sobrino; Juan Ortín; Esteban Domingo
Establishment of cell lines persistently infected with foot-and-mouth disease virus.
Virology 1985;145(1):24-35.
1985: C López-Galindez; Juan Ortín; Esteban Domingo; L del Rio; P Pérez-Breña; R Nájera
Heterogeneity among influenza H3N2 isolates recovered during an outbreak. Brief report.
Archives of virology 1985;85(1-2):139-44.
1985: Esteban Domingo; E Martínez-Salas; Francisco Sobrino; J C de la Torre; Agustín Portela; Juan Ortín; C López-Galindez; P Pérez-Breña; N Villanueva; R Nájera
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review.
Gene 1985;40(1):1-8.
1985: E Martínez-Salas; Juan Ortín; E Domingo
Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8).
Gene 1985;35(1-2):55-61.
1985: L del Río; C Martínez; E Domingo; Juan Ortín
In vitro synthesis of full-length influenza virus complementary RNA.
The EMBO journal 1985;4(1):243-7.
1983: C Martínez; L del Rio; Agustín Portela; E Domingo; Juan Ortín
Evolution of the influenza virus neuraminidase gene during drift of the N2 subtype.
Virology 1983;130(2):539-45.
1983: Juan Ortín; C Martínez; L del Río; Mercedes Dávila; C López-Galíndez; N Villanueva; Esteban Domingo
Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype.
Gene 1983;23(2):233-9.
1983: N Villanueva; Mercedes Dávila; Juan Ortín; Esteban Domingo
Molecular cloning of cDNA from foot-and-mouth disease virus C1-Santa Pau (C-S8). Sequence of protein-VP1-coding segment.
Gene 1983;23(2):185-94.
1983: Francisco Sobrino; Mercedes Dávila; Juan Ortín; Esteban Domingo
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture.
Virology 1983;128(2):310-8.
1980: Juan Ortín; R Nájera; C López; Mercedes Dávila; Esteban Domingo
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome.
Gene 1980;11(3-4):319-31.
1980: Esteban Domingo; Mercedes Dávila; Juan Ortín
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus.
Gene 1980;11(3-4):333-46.