Jan-Bjørn Osnes

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Kjekshus John K; Torp-Pedersen Christian; Gullestad Lars; Køber Lars; Edvardsen Thor; Olsen Inge C; Sjaastad Ivar; Qvigstad Eirik; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure.
Ansteinsson V; Refsnes M; Skomedal T; Osnes J B; Schiander I; Låg M
Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart.
Aursnes Ivar; Osnes Jan-Bjørn
Atenolol versus other beta-adrenergic blockers.

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2009: Kjekshus John K; Torp-Pedersen Christian; Gullestad Lars; Køber Lars; Edvardsen Thor; Olsen Inge C; Sjaastad Ivar; Qvigstad Eirik; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2009;11(8):771-8.
2009: Ansteinsson V; Refsnes M; Skomedal T; Osnes J B; Schiander I; Låg M
Zinc- and copper-induced interleukin-6 release in primary cell cultures from rat heart.
Cardiovascular toxicology 2009;9(2):86-94.
2009: Aursnes Ivar; Osnes Jan-Bjørn
Atenolol versus other beta-adrenergic blockers.
Journal of the American College of Cardiology 2009;53(22):2101-2; author reply 2106-7.
2009: Hussain R I; Qvigstad E; Birkeland J A K; Eikemo H; Glende A; Sjaastad I; Skomedal T; Osnes J B; Levy F O; Krobert K A
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
British journal of pharmacology 2009;156(4):575-86.
2008: Afzal F; Andressen K W; Mørk H K; Aronsen J M; Sjaastad I; Dahl C P; Skomedal T; Levy F O; Osnes J-B; Qvigstad E
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.
British journal of pharmacology 2008;155(7):1005-14.
2008: Eikemo Hilde; Skomedal Tor; Levy Finn Olav; Osnes Jan-Bjørn
Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors.
Analytical biochemistry 2008;383(2):323-5.
2008: Riise Jon; Nguyen Cam H T; Qvigstad Eirik; Sandnes Dagny L; Osnes Jan-Bjørn; Skomedal Tor; Levy Finn Olav; Krobert Kurt A
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
Cardiovascular research 2008;80(3):407-15.
2008: Totlandsdal Annike I; Refsnes Magne; Skomedal Tor; Osnes Jan-Bjørn; Schwarze Per E; Låg Marit
Particle-induced cytokine responses in cardiac cell cultures--the effect of particles versus soluble mediators released by particle-exposed lung cells.
Toxicological sciences : an official journal of the Society of Toxicology 2008;106(1):233-41.
2008: Levy Finn Olav; Qvigstad Eirik; Krobert Kurt A; Skomedal Tor; Osnes Jan-Bjørn
Effects of serotonin in failing cardiac ventricle: signalling mechanisms and potential therapeutic implications.
Neuropharmacology 2008;55(6):1066-71.
2008: Totlandsdal Annike I; Skomedal Tor; Låg Marit; Osnes Jan-Bjørn; Refsnes Magne
Pro-inflammatory potential of ultrafine particles in mono- and co-cultures of primary cardiac cells.
Toxicology 2008;247(1):23-32.
2007: Brattelid Trond; Qvigstad Eirik; Birkeland Jon Arne Kro; Swift Fredrik; Bekkevold Silje V S; Krobert Kurt A; Sejersted Ole M; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav; Sjaastad Ivar
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle.
Journal of molecular and cellular cardiology 2007;43(6):767-79.
2007: Vinge Leif Erik; Andressen Kjetil W; Attramadal Toril; Andersen Geir Øystein; Ahmed Mohammed Shakil; Peppel Karsten; Koch Walter J; Freedman Neil J; Levy Finn Olav; Skomedal Tor; Osnes Jan-Bjørn; Attramadal Håvard
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.
Molecular pharmacology 2007;72(3):582-91.
2007: Brattelid Trond; Tveit Kristine; Birkeland Jon Arne K; Sjaastad Ivar; Qvigstad Eirik; Krobert Kurt Allen; Hussain Rizwan I; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation.
Basic research in cardiology 2007;102(3):198-208.
2007: Birkeland J A K; Sjaastad I; Brattelid T; Qvigstad E; Moberg E R; Krobert K A; Bjørnerheim R; Skomedal T; Sejersted O M; Osnes J-B; Levy F O
Effects of treatment with a 5-HT4 receptor antagonist in heart failure.
British journal of pharmacology 2007;150(2):143-52.
2007: Aursnes Ivar; Osnes Jan-Bjørn; Tvete Ingunn Fride; Gåsemyr Jørund; Natvig Bent
Does atenolol differ from other beta-adrenergic blockers?
BMC clinical pharmacology 2007;7():4.
2006: Andersen Geir Oystein; Oie Erik; Vinge Leif Erik; Yndestad Arne; Attramadal Håvard; Skomedal Tor; Osnes Jan Bjørn
Increased expression and function of the myocardial Na-K-2Cl cotransporter in failing rat hearts.
Basic research in cardiology 2006;101(6):471-8.
2005: Qvigstad Eirik; Sjaastad Ivar; Brattelid Trond; Nunn Caroline; Swift Fredrik; Birkeland Jon Arne Kro; Krobert Kurt A; Andersen Geir Øystein; Sejersted Ole M; Osnes Jan-Bjørn; Levy Finn Olav; Skomedal Tor
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart.
Circulation research 2005;97(3):268-76.
2005: Kemi Ole J; Haram Per M; Loennechen Jan P; Osnes Jan-Bjørn; Skomedal Tor; Wisløff Ulrik; Ellingsen Øyvind
Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function.
Cardiovascular research 2005;67(1):161-72.
2005: Qvigstad Eirik; Sjaastad Ivar; Bøkenes Janny; Schiander Iwona; Solberg Line; Sejersted Ole M; Osnes Jan-Bjørn; Skomedal Tor
Carvedilol blockade of alpha1- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure.
European journal of pharmacology 2005;516(1):51-9.
2005: Qvigstad Eirik; Brattelid Trond; Sjaastad Ivar; Andressen Kjetil Wessel; Krobert Kurt A; Birkeland Jon Arne; Sejersted Ole M; Kaumann Alberto J; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure.
Cardiovascular research 2005;65(4):869-78.
2004: Sandnes Dagny; Nilssen Laila Sortvik; Andersen Geir Oystein; Viko Håvard; Sjetnan Anne E; Skomedal Tor; Osnes Jan-Bjørn
Ca2+-dependent elevation of inositol 1,4,5-trisphosphate level induced by freezing or homogenization of tissues and cells.
Basic & clinical pharmacology & toxicology 2004;95(6):288-94.
2004: Brattelid Trond; Qvigstad Eirik; Lynham James A; Molenaar Peter; Aass Halfdan; Geiran Odd; Skomedal Tor; Osnes Jan-Bjørn; Levy Finn Olav; Kaumann Alberto J
Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(3):157-66.
2004: Andersen Geir Øystein; Skomedal Tor; Enger Mette; Fidjeland Astrid; Brattelid Trond; Levy Finn Olav; Osnes Jan-Bjørn
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1354-60.
2003: Qvigstad Eirik; Osnes Jan Bjørn; Sandnes Dagny; Schiander Iwona; Bøkenes Janny; Sjaastad Ivar; Skomedal Tor
Carvedilol blockade of rat myocardial alpha1-adrenoceptors.
European journal of pharmacology 2003;481(1):83-9.
2003: Beisvag V; Falck G; Loennechen J P; Qvigstad G; Jynge P; Skomedal T; Osnes J-B; Sandvik A K; Ellingsen Ø
Identification and regulation of the gastric H+/K+-ATPase in the rat heart.
Acta physiologica Scandinavica 2003;179(3):251-62.
2003: Sjaastad I; Schiander I; Sjetnan A; Qvigstad E; Bøkenes J; Sandnes D; Osnes J-B; Sejersted O M; Skomedal T
Increased contribution of alpha 1- vs. beta-adrenoceptor-mediated inotropic response in rats with congestive heart failure.
Acta physiologica Scandinavica 2003;177(4):449-58.
2002: Andersen Geir Øystein; Qvigstad Eirik; Schiander Iwona; Aass Halfdan; Osnes Jan-Bjørn; Skomedal Tor
Alpha(1)-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1471-80.
2001: Skomedal T; Aass H; Geiran O; Osnes J B
Differential effects of cocaine on the positive inotropic effect of noradrenaline mediated by alpha1- and beta-adrenoceptors in failing human myocardium.
European journal of pharmacology 2001;419(2-3):223-30.
2000: Borthne K; Langslet A; Lindberg H; Skomedal T; Osnes J B
Differential recruitment of alpha 1- and beta-adrenoceptors in inotropic control of atrial child myocardium by endogenous noradrenaline.
Acta physiologica Scandinavica 2000;170(1):21-31.
2000: Osnes J B; Aass H; Andersen G O; Skomedal T
First-line antihypertensive therapy.
Lancet 2000;356(9228):509-10.
2000: Andersen G O; Enger M; Skomedal T; Osnes J B
Angiotensin II activates a bumetanide sensitive increase in 86RB+ efflux in the rat heart.
Research communications in molecular pathology and pharmacology 2000;107(1-2):89-104.
1999: Dybvik T; Osnes J B; Skomedal T
Similar localisation of alpha1- and beta-adrenoceptors in rabbit heart in relation to sympathetic nerve endings.
European journal of pharmacology 1999;381(2-3):135-40.
1999: Borthne K; Langslet A; Lindberg H; Osnes J B; Skomedal T
Endogenous muscarinic activity attenuates adrenergic inotropic effects in field stimulated atrial myocardium from children with congenital heart defects.
Acta physiologica Scandinavica 1999;165(1):9-13.
1998: Andersen G O; Enger M; Thoresen G H; Skomedal T; Osnes J B
Alpha1-adrenergic activation of myocardial Na-K-2Cl cotransport involving mitogen-activated protein kinase.
The American journal of physiology 1998;275(2 Pt 2):H641-52.
1998: Viko H; Sandnes D; Skomedal T; Osnes J B
Effect of concomitant beta-adrenoceptor stimulation on alpha 1-adrenoceptor-mediated increase of inositol-1,4,5-trisphosphate mass in adult rat cardiomyocytes.
Pharmacology & toxicology 1998;83(1):23-8.
1997: Andersen G O; Enger M; Skomedal T; Osnes J B
Receptor subtypes involved in the alpha1-adrenoceptor mediated increase in 86Rb+ efflux from the rat heart.
Japanese journal of pharmacology 1997;75(2):171-8.
1997: Skomedal T; Fu M L; Hjalmarson A; Hoebeke J; Schiander I G; Osnes J B
Anti-M2 muscarinic receptor antibodies inhibit beta-adrenoceptor-mediated inotropic response in rat myocardium.
European journal of pharmacology 1997;333(2-3):169-75.
1997: Andersen G O; Enger M; Skomedal T; Osnes J B
Alpha 1-adrenoceptor mediated activation of Na/K/2Cl cotransport and K+ channels in the rat heart involves different receptor subtypes.
Research communications in molecular pathology and pharmacology 1997;96(3):329-40.
1997: Aass H; Johannessen S I; Osnes J B; Skomedal T; Stokke K T
[Serum digitoxin in concomitant use of antiepileptics in routine therapy]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1997;117(14):2032-5.
1997: Viko H; Osnes J B; Skomedal T
The Na+/K+ATPase mediates the alpha 1-adrenoceptor stimulated increase in 86Rb(+)-uptake in isolated ventricular cardiomyocytes from adult rat heart.
Research communications in molecular pathology and pharmacology 1997;96(1):89-106.
1997: Viko H; Osnes J B; Sandnes D; Skomedal T
Alpha 1-adrenoceptor subtypes involved in increased 86Rb+ influx rate and inositol 1,4,5-trisphosphate mass in adult rat cardiomyocytes.
European journal of pharmacology 1997;323(2-3):269-75.
1997: Skomedal T; Borthne K; Aass H; Geiran O; Osnes J B
Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle.
The Journal of pharmacology and experimental therapeutics 1997;280(2):721-9.
1996: Viko H; Osnes J B; Skomedal T
Alpha(1)- and beta-adrenoceptor-mediated increase in 86Rb(+)-uptake in isolated cardiomyocytes from adult rat heart: evidence for interaction between the two receptor systems.
Pharmacology & toxicology 1996;79(6):287-92.
1996: Hanem S; Enger M; Skomedal T; Osnes J B
Inositol-1,4,5-trisphosphate mass content in isolated perfused rat heart during alpha-1-adrenoceptor stimulation.
Molecular and cellular biochemistry 1996;163-164():167-72.
1996: Andersen G O; Enger M; Skomedal T; Osnes J B
Concentration-response relationship of alpha 1-adrenoceptor-stimulated increase of 86Rb+ efflux in rat heart.
Pharmacology & toxicology 1996;79(4):169-76.
1995: Dybvik T; Osnes J B; Skomedal T
Location of alpha 1-adrenoceptors relative to beta-adrenoceptors in rat myocardium.
European journal of pharmacology 1995;281(1):21-7.
1995: Borthne K; Hågå P; Langslet A; Lindberg H; Skomedal T; Osnes J B
Endogenous norepinephrine stimulates both alpha 1- and beta-adrenoceptors in myocardium from children with congenital heart defects.
Journal of molecular and cellular cardiology 1995;27(1):693-9.
1995: Viko H; Osnes J B; Sjetnan A E; Skomedal T
Improved isolation of cardiomyocytes by trypsination in addition to collagenase treatment.
Pharmacology & toxicology 1995;76(1):68-71.
1994: Hanem S; Enger M; Skomedal T; Osnes J B
Increased intracellular potassium and water contents in rat heart after alpha-1-adrenoceptor stimulation.
Pharmacology & toxicology 1994;75(5):294-301.
1994: Skomedal T; Høstmark A T; Osnes J B
Fat diet, osmotic fragility of erythrocytes and inotropic response of rat heart papillary muscle to noradrenaline stimulation: early appearance of the diet effect by lovastatin.
Pharmacology & toxicology 1994;75(3-4):200-5.
1994: Borthne K; Hågå P; Langslet A; Lindberg H; Osnes J B; Skomedal T
Functional characterization of an ex vivo preparation of atrial myocardium from children with congenital heart defects: sensitivity to tyramine and adrenoceptor antagonists.
Journal of cardiovascular pharmacology 1994;24(3):365-71.
1994: Hanem S; Skomedal T; Osnes J B
Alpha 1-adrenoceptor stimulation increases 86Rb+ influx in perfused rat heart.
Journal of cardiovascular pharmacology 1994;24(2):261-5.
1994: Hanem S; Grønås T; Holten T; Jynge P; Skomedal T; Osnes J B
Intracellular pH measured by 31P-NMR in isolated rat heart during alpha-1-adrenoceptor stimulation.
Journal of molecular and cellular cardiology 1994;26(5):669-74.
1993: Aursnes I; Osnes J B; Platou E S; Smiseth O A
[Lipid-lowering medication--indications and possible hazards. Report from a hearing]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1993;113(23):2930-2.
1993: Skomedal T; Osnes J B; Johannessen S I; Lund P K; Aass H
[Therapeutic drug monitoring with the help of serum concentration measurements. How are the analytic results distributed in a population?]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1993;113(18):2242-6.
1992: Osnes J B
[Treatment of hypertension in the elderly--diuretics/atenolol?]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1992;112(17):2235-6.
1992: Hanem S; Skomedal T; Osnes J B
Accumulation of potassium and calcium in rat myocardium exposed to alpha-1-adrenoceptor stimulation.
Pharmacology & toxicology 1992;70(4):303-7.
1992: Aursnes I; Osnes J B; Platou E S
[What can be achieved by treatment with antihypertensive agents? Report from a hearing]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1992;112(1):53-5.
1991: Skomedal T; Schiander I G; Husøy E A; Tveiten A; Osnes J B
Lithium increases the alpha 1-adrenoceptor mediated inotropic effect in rat heart.
Pharmacology & toxicology 1991;68(2):88-92.
1990: Aursnes I; Osnes J B; Platou E S; Smiseth O A; Amlie J P
[Drug therapy of acute coronary syndrome. Summary of a hearing arranged by the Norwegian Cardiologic Society and the Institute of pharmacotherapy]
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1990;110(21):2788-90.
1990: Skomedal T; Aass H; Osnes J B
Both alpha 1- and beta-adrenoceptor stimulation determine the time course of the inotropic effect of noradrenaline in rabbit heart.
Pharmacology & toxicology 1990;67(2):172-7.
1990: Skomedal T; Aass H; Osnes J B
Prazosin-sensitive component of the inotropic response to norepinephrine in rabbit heart.
The Journal of pharmacology and experimental therapeutics 1990;252(2):853-8.
1989: Osnes J B; Aass H; Skomedal T
Adrenoceptors in myocardial regulation: concomitant contribution from both alpha- and beta-adrenoceptor stimulation to the inotropic response.
Basic research in cardiology 1989;84 Suppl 1():9-17.
1988: Skomedal T; Schiander I G; Osnes J B
Both alpha and beta adrenoceptor-mediated components contribute to final inotropic response to norepinephrine in rat heart.
The Journal of pharmacology and experimental therapeutics 1988;247(3):1204-10.
1988: Aass H; Skomedal T; Osnes J B
Increase of cyclic AMP in subcellular fractions of rat heart muscle after beta-adrenergic stimulation: prenalterol and isoprenaline caused different distribution of bound cyclic AMP.
Journal of molecular and cellular cardiology 1988;20(9):847-60.
1988: Skomedal T; Schiander I; Aass H; Osnes J B
Properties of the inotropic response in rat papillary muscles to the dihydropyridine "Ca-channel activator" BAY K 8644.
Pharmacology & toxicology 1988;63(1):20-5.
1987: Skomedal T; Schiander I; Aass H; Osnes J B
Qualitative characteristics of the mechanical response in rat papillary muscles to increase in extracellular calcium concentration.
Acta physiologica Scandinavica 1987;131(3):347-53.
1987: Christiansen H B; Horgmo G I; Skomedal T; Osnes J B
Enhancement of the alpha-adrenergic inotropic component of noradrenaline by simultaneous stimulation of muscarinic acetylcholine receptors in rat myocardium.
European journal of pharmacology 1987;142(1):93-102.
1987: Osnes J B; Christiansen H B; Horgmo G I; Schiander I G; Skomedal T
Alpha-adrenergic stimulation contributes to the inotropic effect of noradrenaline.
Biomedica biochimica acta 1987;46(8-9):S417-20.
1986: Aass H; Skomedal T; Osnes J B; Fjeld N B; Klingen G; Langslet A; Svennevig J; Semb G
Noradrenaline evokes an alpha-adrenoceptor-mediated inotropic effect in human ventricular myocardium.
Acta pharmacologica et toxicologica 1986;58(1):88-90.
1985: Skomedal T; Aass H; Osnes J B; Fjeld N B; Klingen G; Langslet A; Semb G
Demonstration of an alpha adrenoceptor-mediated inotropic effect of norepinephrine in human atria.
The Journal of pharmacology and experimental therapeutics 1985;233(2):441-6.
1984: Skomedal T; Aass H; Osnes J B
Specific binding of [3H]prazosin to myocardial cells isolated from adult rats.
Biochemical pharmacology 1984;33(12):1897-906.
1983: Aass H; Skomedal T; Osnes J B
Effects of trifluoperazine on beta-adrenergic responses of rat papillary muscle: related to calmodulin?
Acta pharmacologica et toxicologica 1983;53(4):265-74.
1983: Aass H; Skomedal T; Osnes J B
Demonstration of an alpha adrenoceptor-mediated inotropic effect of norepinephrine in rabbit papillary muscle.
The Journal of pharmacology and experimental therapeutics 1983;226(2):572-8.
1983: Aass H; Hedberg A; Skomedal T; Carlsson E; Osnes J B
Characterization of mechanical effects and beta-adrenoceptor binding of prenalterol in rat myocardium.
Acta pharmacologica et toxicologica 1983;53(1):3-11.
1983: Aass H; Hedberg A; Skomedal T; Carlsson E; Osnes J B
Lack of functional influence by prenalterol through alpha 1-adrenoceptors in rat myocardium.
Acta pharmacologica et toxicologica 1983;53(1):12-5.
1983: Skomedal T; Osnes J B
Qualitative differences between the inotropic responses in rat papillary muscles to alpha-adrenoceptor and beta-adrenoceptor stimulation by both noradrenaline and adrenaline.
Acta pharmacologica et toxicologica 1983;52(1):57-67.
1982: Skomedal T; Osnes J B; Oye I
Differences between alpha-adrenergic and beta-adrenergic inotropic effects in rat heart papillary muscles.
Acta pharmacologica et toxicologica 1982;50(1):1-12.
1981: Skomedal T; Osnes J B; Oye I
Mechanical response of rat myocardium to dibutyryl cyclic AMP in relation to effects of alpha-and beta-adrenoceptor stimulators.
Acta pharmacologica et toxicologica 1981;49(2):81-91.
1980: Skomedal T; Osnes J B; Oye I
Competitive blockade of alpha-adrenergic receptors in rat heart by prazosin.
Acta pharmacologica et toxicologica 1980;47(3):217-22.
1980: Skomedal T; Grynne B; Osnes J B; Sjetnan A E; Oye I
A radioimmunoassay for cyclic AMP (cAMP) obtained by acetylation of both unlabeled and labeled (3H-cAMP) ligand, or of unlabeled ligand only.
Acta pharmacologica et toxicologica 1980;46(3):200-4.

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