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Beth Ostaszewski

Research Profile

Chemicals & Drugs

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Alzheimer's Disease

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Soyon Hong; Beth L Ostaszewski; Daniel R Podlisny; Omar Quintero-Monzon; William T Cavanaugh; John R Cirrito; David M Holtzman; Ting Yang; Dennis J Selkoe
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
Andreas Weihofen; Kelly Jean Thomas; Beth L Ostaszewski; Mark Cookson; Dennis J Selkoe
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Andreas Weihofen; Beth L Ostaszewski; Yasufumi Minami; Dennis J Selkoe
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

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All Publications

2011: Soyon Hong; Beth L Ostaszewski; Daniel R Podlisny; Omar Quintero-Monzon; William T Cavanaugh; John R Cirrito; David M Holtzman; Ting Yang; Dennis J Selkoe
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(44):15861-9.
2009: Andreas Weihofen; Kelly Jean Thomas; Beth L Ostaszewski; Mark Cookson; Dennis J Selkoe
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Biochemistry 2009;48(9):2045-52.
2008: Andreas Weihofen; Beth L Ostaszewski; Yasufumi Minami; Dennis J Selkoe
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Human molecular genetics 2008;17(4):602-16.
2007: Matthew J LaVoie; Giuseppe P Cortese; Beth L Ostaszewski; Michael G Schlossmacher
The effects of oxidative stress on parkin and other E3 ligases.
Journal of neurochemistry 2007;103(6):2354-68.
2005: Patrick C Fraering; Wenjuan Ye; Matthew J LaVoie; Beth L Ostaszewski; Dennis J Selkoe; Michael S Wolfe
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
The Journal of biological chemistry 2005;280(51):41987-96.
2005: Matthew J LaVoie; Beth L Ostaszewski; Andreas Weihofen; Michael G Schlossmacher; Dennis J Selkoe
Dopamine covalently modifies and functionally inactivates parkin.
Nature medicine 2005;11(11):1214-21.
2004: Patrick C Fraering; Wenjuan Ye; Jean-Marc Strub; Georgia Dolios; Matthew J LaVoie; Beth L Ostaszewski; Alain Van Dorsselaer; Rong Wang; Dennis J Selkoe; Michael S Wolfe
Purification and characterization of the human gamma-secretase complex.
Biochemistry 2004;43(30):9774-89.
2004: Patrick C Fraering; Matthew J LaVoie; Wenjuan Ye; Beth L Ostaszewski; W Taylor Kimberly; Dennis J Selkoe; Michael S Wolfe
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Biochemistry 2004;43(2):323-33.
2003: Matthew J LaVoie; Patrick C Fraering; Beth L Ostaszewski; Wenjuan Ye; W Taylor Kimberly; Michael S Wolfe; Dennis J Selkoe
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The Journal of biological chemistry 2003;278(39):37213-22.
2003: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6382-7.
2003: W Taylor Kimberly; William P Esler; Wenjuan Ye; Beth L Ostaszewski; Jun Gao; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2002: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
The Journal of biological chemistry 2002;277(38):35113-7.
2002: William P Esler; Chittaranjan Das; William A Campbell; W Taylor Kimberly; Anna Y Kornilova; Thekla S Diehl; Wenjuan Ye; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2000: Weiming Xia; Beth L Ostaszewski; W Taylor Kimberly; T Rahmati; CL Moore; Michael S Wolfe; Dennis J Selkoe
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiology of disease 2000;7(6 Pt B):673-81.
2000: Weiming Xia; William Ray; Beth L Ostaszewski; T Rahmati; W Taylor Kimberly; Michael S Wolfe; Jimin Zhang; Alison Goate; Dennis J Selkoe
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9299-304.
2000: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Thekla S Diehl; CL Moore; J Y Tsai; T Rahmati; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
1999: Ruth G Perez; Salvador Soriano; J D Hayes; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; X Chen; Gorazd B Stokin; Edward H Koo
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
The Journal of biological chemistry 1999;274(27):18851-6.
1999: Michael S Wolfe; Weiming Xia; CL Moore; D D Leatherwood; Beth L Ostaszewski; T Rahmati; Isaac O Donkor; Dennis J Selkoe
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry 1999;38(15):4720-7.
1999: Michael S Wolfe; Weiming Xia; Beth L Ostaszewski; Thekla S Diehl; W Taylor Kimberly; Dennis J Selkoe
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature 1999;398(6727):513-7.
1998: Weiming Xia; Jimin Zhang; Beth L Ostaszewski; W Taylor Kimberly; Peter Seubert; Edward H Koo; Jie Shen; Dennis J Selkoe
Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Biochemistry 1998;37(47):16465-71.
1998: Martin Citron; Christopher B Eckman; Thekla S Diehl; C Corcoran; Beth L Ostaszewski; Weiming Xia; Georges Levesque; Peter St George-Hyslop; Steven G Younkin; Dennis J Selkoe
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: Marcia B Podlisny; Dominic M Walsh; P Amarante; Beth L Ostaszewski; Evelyn R Stimson; John E Maggio; David B Teplow; Dennis J Selkoe
Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.
Biochemistry 1998;37(11):3602-11.
1996: A L Biere; Beth L Ostaszewski; Evelyn R Stimson; Bradley T Hyman; John E Maggio; Dennis J Selkoe
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma.
The Journal of biological chemistry 1996;271(51):32916-22.
1995: A L Biere; Beth L Ostaszewski; H Zhao; S Gillespie; Steven G Younkin; Dennis J Selkoe
Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing.
Neurobiology of disease 1995;2(3):177-87.
1995: Marcia B Podlisny; Beth L Ostaszewski; Sharon Squazzo; Edward H Koo; R E Rydell; David B Teplow; Dennis J Selkoe
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.
The Journal of biological chemistry 1995;270(16):9564-70.
1992: Christian Haass; Michael G Schlossmacher; A Y Hung; C Vigo-Pelfrey; A Mellon; Beth L Ostaszewski; I Lieberburg; Edward H Koo; Dale Schenk; David B Teplow
Amyloid beta-peptide is produced by cultured cells during normal metabolism.
Nature 1992;359(6393):322-5.
1992: Michael G Schlossmacher; Beth L Ostaszewski; L I Hecker; A Celi; Christian Haass; D Chin; I Lieberburg; B C Furie; B Furie; Dennis J Selkoe
Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Neurobiology of aging 1992;13(3):421-34.