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Andrei Osterman

Research Profile

Genes & Molecular Sequences

Chemicals & Drugs

Concepts & Ideas

Procedures

X Ray Crystallography

Occupations

Living Beings

Physiology

Gene Expression Regulation, Bacterial

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Publications

TOP 3
Leonardo Sorci; Sergey Tkachenko; Irina A Rodionova; Ian Blaby; Valérie de Crécy-Lagard; Jessica De Ingeniis; Andrei Osterman
Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.
Marat D Kazanov; Xiaoqing Li; Andrei Osterman; Mikhail S Gelfand; Dmitry A Rodionov
Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum.
Irina A Rodionova; Chen Yang; Aaron A Best; Oleg V Kurnasov; Xiaoqing Li; Andrei Osterman; Dmitry A Rodionov
Diversity and versatility of the Thermotoga maritima sugar kinome.

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All Publications

2013: Leonardo Sorci; Sergey Tkachenko; Irina A Rodionova; Ian Blaby; Valérie de Crécy-Lagard; Jessica De Ingeniis; Andrei Osterman
Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.
Journal of bacteriology 2013;195(4):726-32.
2013: Marat D Kazanov; Xiaoqing Li; Andrei Osterman; Mikhail S Gelfand; Dmitry A Rodionov
Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum.
Nucleic acids research 2013;41(2):790-803.
2012: Irina A Rodionova; Chen Yang; Aaron A Best; Oleg V Kurnasov; Xiaoqing Li; Andrei Osterman; Dmitry A Rodionov
Diversity and versatility of the Thermotoga maritima sugar kinome.
Journal of bacteriology 2012;194(20):5552-63.
2012: Dmitry A Ravcheev; Karsten Zengler; Alexey E Kazakov; Yuri D Korostelev; Haythem Latif; Semen A Leyn; Xiaoqing Li; Pavel Novichkov; Andrei Osterman; Dmitry A Rodionov
Transcriptional regulation of central carbon and energy metabolism in bacteria by redox-responsive repressor Rex.
Journal of bacteriology 2012;194(5):1145-57.
2012: Sung-il Yoon; Andrei V Gudkov; Minsun Hong; Oleg Kurnasov; Venkatesh Natarajan; Andrei Osterman; Ian A Wilson
Structural basis of TLR5-flagellin recognition and signaling.
Science (New York, N.Y.) 2012;335(6070):859-64.
2011: Dmitry A Rodionov; Irina A Rodionova; Margaret F Romine; Elena D Stavrovskaya; Adam P Arkin; Inna Dubchak; James K Fredrickson; Anna V Gerasimova; Alexey E Kazakov; Marat D Kazanov; Galina Yu Kovaleva; Olga N Laikova; Xiaoqing Li; Pavel Novichkov; Andrei Osterman; Ross Overbeek; Elizaveta A Permina; Dmitry A Ravcheev; Mikhail S Gelfand
Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus.
BMC genomics 2011;12 Suppl 1():S3.
2010: Nian Huang; Rohit Kolhatkar; Yvonne Eyobo; Leonardo Sorci; Irina Rodionova; Andrei Osterman; Alexander D. Mackerell; Hong Zhang
Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
Journal of medicinal chemistry 2010;53(14):5229-39.
2010: Grigoriy E Pinchuk; Eric A Hill; Oleg V Geydebrekht; Jessica De Ingeniis; Xiaolin Zhang; Andrei Osterman; James H Scott; Samantha B Reed; Margaret F Romine; Allan E Konopka; Alexander S Beliaev; Jim K Fredrickson; Jennifer L Reed
Constraint-based model of Shewanella oneidensis MR-1 metabolism: a tool for data analysis and hypothesis generation.
PLoS computational biology 2010;6(6):e1000822.
2010: Dmitry A Rodionov; Chen Yang; Xiaoqing Li; Irina A Rodionova; Yanbing Wang; Anna Y Obraztsova; Olga Zagnitko; Ross Overbeek; Margaret F Romine; Samantha Reed; James K Fredrickson; Kenneth H Nealson; Andrei Osterman
Genomic encyclopedia of sugar utilization pathways in the Shewanella genus.
BMC genomics 2010;11():494.
2009: Ying Zhang; Ines Thiele; Dana Weekes; Zhanwen Li; Lukasz Jaroszewski; Krzysztof Ginalski; Ashley M Deacon; John Wooley; Scott A Lesley; Ian A Wilson; Bernhard Palsson; Andrei Osterman; Adam Godzik
Three-dimensional structural view of the central metabolic network of Thermotoga maritima.
Science (New York, N.Y.) 2009;325(5947):1544-9.
2009: Leonardo Sorci; Yongping Pan; Yvonne Eyobo; Irina Rodionova; Nian Huang; Oleg V Kurnasov; Shijun Zhong; Alexander D. Mackerell; Hong Zhang; Andrei Osterman
Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Chemistry & biology 2009;16(8):849-61.
2009: Leonardo Sorci; Dariusz Martynowski; Dmitry A Rodionov; Yvonne Eyobo; Xhavit Zogaj; Karl E Klose; Evgeni V Nikolaev; Giulio Magni; Hong Zhang; Andrei Osterman
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3083-8.
2009: Grigory E Pinchuk; Dmitry A Rodionov; Chen Yang; Xiaoqing Li; Andrei Osterman; Etienne Dervyn; Oleg V Geydebrekht; Samantha B Reed; Margaret F Romine; Frank R Collart; James H Scott; James K Fredrickson; Alexander S Beliaev
Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2874-9.
2008: Adam Richardson; Chen Yang; Andrei Osterman; Jeffrey W Smith
Central carbon metabolism in the progression of mammary carcinoma.
Breast cancer research and treatment 2008;110(2):297-307.
2008: Lyudmila G Burdelya; Vadim I Krivokrysenko; Thomas C Tallant; Evguenia Strom; Anatoly S Gleiberman; Damodar Gupta; Oleg V Kurnasov; Farrel L Fort; Andrei Osterman; Joseph A Didonato; Elena Feinstein; Andrei V Gudkov
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.
Science (New York, N.Y.) 2008;320(5873):226-30.
2008: Dmitry A Rodionov; Xiaoqing Li; Irina A Rodionova; Chen Yang; Leonardo Sorci; Etienne Dervyn; Dariusz Martynowski; Hong Zhang; Mikhail S Gelfand; Andrei Osterman
Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon.
Nucleic acids research 2008;36(6):2032-46.
2008: Dmitry A Rodionov; Jessica De Ingeniis; Chiara Mancini; Flavio Cimadamore; Hong Zhang; Andrei Osterman; Nadia Raffaelli
Transcriptional regulation of NAD metabolism in bacteria: NrtR family of Nudix-related regulators.
Nucleic acids research 2008;36(6):2047-59.
2008: Chen Yang; Dmitry A Rodionov; Irina A Rodionova; Xiaoqing Li; Andrei Osterman
Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways.
Journal of bacteriology 2008;190(5):1773-82.
2008: Nian Huang; Leonardo Sorci; Xuejun Zhang; Chad A Brautigam; Xiaoqing Li; Nadia Raffaelli; Giulio Magni; Nick V Grishin; Andrei Osterman; Hong Zhang
Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism.
Structure (London, England : 1993) 2008;16(2):196-209.
2008: Andrei Osterman; Svetlana Y Gerdes
Comparative approach to analysis of gene essentiality.
Methods in molecular biology (Clifton, N.J.) 2008;416():459-66.
2008: Ramy Aziz; Daniela Bartels; Aaron A Best; Matthew DeJongh; Terrence Disz; Robert A Edwards; Kevin Formsma; Svetlana Y Gerdes; Elizabeth M Glass; Michael Kubal; Folker Meyer; Gary J Olsen; Robert Olson; Andrei Osterman; Ross A Overbeek; Leslie Klis McNeil; Daniel Paarmann; Tobias Paczian; Bruce Parrello; Gordon Pusch; Claudia Reich; Rick Stevens; Olga Vassieva; Veronika Vonstein; Andreas Wilke; Olga Zagnitko
The RAST Server: rapid annotations using subsystems technology.
BMC genomics 2008;9():75.
2007: Jean-Marie Bruey; Nathalie Bruey-Sedano; Frederic Luciano; Dayong Zhai; ruchi bajpai; Chunyan Xu; Christina L Kress; Beatrice Bailly-Maitre; Xiaoqing Li; Andrei Osterman; Shu-ichi Matsuzawa; Alexey V Terskikh; Benjamin Faustin; John C Reed
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Cell 2007;129(1):45-56.
2007: Dmitry A Rodionov; Oleg V Kurnasov; Boguslaw Stec; Yan Wang; Mary F Roberts; Andrei Osterman
Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4279-84.
2007: Chen Yang; Adam Richardson; Jeffrey W Smith; Andrei Osterman
Comparative metabolomics of breast cancer.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2007;():181-92.
2007: Leslie Klis McNeil; Claudia I Reich; Ramy Aziz; Daniela Bartels; Matthew cohoon; Terry Disz; Robert A Edwards; Svetlana Y Gerdes; Kaitlyn Hwang; Michael Kubal; Gohar Rem Margaryan; Folker Meyer; William Mihalo; Gary J Olsen; Robert Olson; Andrei Osterman; Daniel Paarmann; Tobias Paczian; Bruce Parrello; Gordon Pusch; Dmitry A Rodionov; Xinghua Shi; Olga Vassieva; Veronika Vonstein; Olga Zagnitko; Fangfang Xia; Jenifer Zinner; Ross Overbeek; Rick Stevens
The National Microbial Pathogen Database Resource (NMPDR): a genomics platform based on subsystem annotation.
Nucleic acids research 2007;35(Database issue):D347-53.
2007: Yoshinobu Igarashi; Alexey Eroshkin; Svetlana Gramatikova; Kosi Gramatikoff; Ying Zhang; Jeffrey W Smith; Andrei Osterman; Adam Godzik
CutDB: a proteolytic event database.
Nucleic acids research 2007;35(Database issue):D546-9.
2006: Chen Yang; Dmitry A Rodionov; Xiaoqing Li; Olga N Laikova; Mikhail S Gelfand; Olga Zagnitko; Margaret F Romine; Anna Y Obraztsova; Kenneth H Nealson; Andrei Osterman
Comparative genomics and experimental characterization of N-acetylglucosamine utilization pathway of Shewanella oneidensis.
The Journal of biological chemistry 2006;281(40):29872-85.
2006: Svetlana Y Gerdes; Robert Edwards; Michael Kubal; Michael Fonstein; Rick Stevens; Andrei Osterman
Essential genes on metabolic maps.
Current opinion in biotechnology 2006;17(5):448-56.
2006: Andrei Osterman
A hidden metabolic pathway exposed.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5637-8.
2006: Svetlana Y Gerdes; Oleg V Kurnasov; Konstantin Y Shatalin; Boris Polanuyer; Roman Sloutsky; Veronika Vonstein; Ross Overbeek; Andrei Osterman
Comparative genomics of NAD biosynthesis in cyanobacteria.
Journal of bacteriology 2006;188(8):3012-23.
2005: low lieh; Chen Yang; Marta Perego; Andrei Osterman; Robert C Liddington
Structure and lytic activity of a Bacillus anthracis prophage endolysin.
The Journal of biological chemistry 2005;280(42):35433-9.
2005: Vladislav Golubkov; Sarah Boyd; Alexei Y Savinov; Alexei V Chekanov; Andrei Osterman; Albert G Remacle; Dmitri V Rozanov; Stephen J Doxsey; Alex Y Strongin
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.
The Journal of biological chemistry 2005;280(26):25079-86.
2005: Yuzhen Ye; Andrei Osterman; Ross Overbeek; Adam Godzik
Automatic detection of subsystem/pathway variants in genome analysis.
Bioinformatics (Oxford, England) 2005;21 Suppl 1():i478-86.
2004: Andres Alonso; Joanna Sasin; Nunzio Bottini; Iddo Friedberg; Iddo Friedberg; Andrei Osterman; Adam Godzik; Tony Hunter; Jack Dixon; Tomas Mustelin
Protein tyrosine phosphatases in the human genome.
Cell 2004;117(6):699-711.
2004: Jonathan S Melnick; Ewa Lis; Joo-Heon Park; Cynthia Kinsland; Hirotada Mori; Tomoya Baba; John Perkins; Ghislain Schyns; Olga Vassieva; Andrei Osterman; Tadhg P Begley
Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase.
Journal of bacteriology 2004;186(11):3660-2.
2003: Oleg V Kurnasov; Vasiliy Goral; Keri L Colabroy; Svetlana Y Gerdes; Shubha Anantha; Andrei Osterman; Tadhg P Begley
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
Chemistry & biology 2003;10(12):1195-204.
2003: Subburamu Karthikeyan; Qingxian Zhou; Andrei Osterman; Hong Zhang
Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.
Biochemistry 2003;42(43):12532-8.
2003: Oleg V Kurnasov; Lynn Jablonski; Boris Polanuyer; Pieter dorrestein; Tadhg Begley; Andrei Osterman
Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase.
FEMS microbiology letters 2003;227(2):219-27.
2003: Svetlana Y Gerdes; M D Scholle; John W Campbell; Gábor Balázsi; Erzsébet Ravasz; Matthew D Daugherty; A L Somera; Nikos Kyrpides; Iain Anderson; M S Gelfand; A Bhattacharya; Vinayak Kapatral; Mark D'Souza; Mark V Baev; Yuri Grechkin; Faika Mseeh; Michael Fonstein; Ross Overbeek; A-L Barabási; Zoltan N. Oltvai; Andrei Osterman
Experimental determination and system level analysis of essential genes in Escherichia coli MG1655.
Journal of bacteriology 2003;185(19):5673-84.
2003: Xuejun Zhang; Oleg V Kurnasov; Subburamu Karthikeyan; Nick V Grishin; Andrei Osterman; Hong Zhang
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis.
The Journal of biological chemistry 2003;278(15):13503-11.
2003: Andrei Osterman; Ross Overbeek
Missing genes in metabolic pathways: a comparative genomics approach.
Current opinion in chemical biology 2003;7(2):238-51.
2003: Subburamu Karthikeyan; Qingxian Zhou; Faika Mseeh; Nick V Grishin; Andrei Osterman; Hong Zhang
Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch.
Structure (London, England : 1993) 2003;11(3):265-73.
2003: Alexei E Kazakov; Olga Vassieva; Mikhail S Gelfand; Andrei Osterman; Ross Overbeek
Bioinformatics classification and functional analysis of PhoH homologs.
In silico biology 2003;3(1-2):3-15.
2003: Ross Overbeek; Niels Larsen; Theresa Walunas; Mark D'Souza; Gordon Pusch; Eugene Selkov; Konstantinos Liolios; Victor Joukov; Denis Kaznadzey; Iain Anderson; Anamitra Bhattacharyya; Henry Burd; Warren Gardner; Paul Hanke; Vinayak Kapatral; Natalia Mikhailova; Olga Vasieva; Andrei Osterman; Veronika Vonstein; Michael Fonstein; Natalia Ivanova; Nikos Kyrpides
The ERGO genome analysis and discovery system.
Nucleic acids research 2003;31(1):164-71.
2002: Oleg V Kurnasov; Boris Polanuyer; Shubha Ananta; Roman Sloutsky; Annie Tam; Svetlana Y Gerdes; Andrei Osterman
Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis.
Journal of bacteriology 2002;184(24):6906-17.
2002: S Kumar Singh; Oleg V Kurnasov; Baozhi Chen; Howard Robinson; Nick V Grishin; Andrei Osterman; Hong Zhang
Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities.
The Journal of biological chemistry 2002;277(36):33291-9.
2002: Svetlana Y Gerdes; Michael D Scholle; Mark D'Souza; Axel Bernal; Mark V Baev; Michael Farrell; Oleg V Kurnasov; Matthew D Daugherty; Faika Mseeh; Boris Polanuyer; John W Campbell; Shubha Anantha; Konstantin Y Shatalin; Shamim A K Chowdhury; Michael Fonstein; Andrei Osterman
From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways.
Journal of bacteriology 2002;184(16):4555-72.
2002: Matthew D Daugherty; Boris Polanuyer; Michael Farrell; Michael Scholle; Athanasios Lykidis; Valérie de Crécy-Lagard; Andrei Osterman
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.
The Journal of biological chemistry 2002;277(24):21431-9.
2002: Tianjun Zhou; Oleg V Kurnasov; Diana R Tomchick; Derk D Binns; Nick V Grishin; Victor E Marquez; Andrei Osterman; Hong Zhang
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
The Journal of biological chemistry 2002;277(15):13148-54.
2002: Hong Zhang; Tianjun Zhou; Oleg V Kurnasov; Sara Cheek; Nick V Grishin; Andrei Osterman
Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD.
Structure (London, England : 1993) 2002;10(1):69-79.
2001: S Sri Krishna; Tianjun Zhou; Matthew D Daugherty; Andrei Osterman; Hong Zhang
Structural basis for the catalysis and substrate specificity of homoserine kinase.
Biochemistry 2001;40(36):10810-8.
2001: Tadhg P Begley; Cynthia Kinsland; Ryan A Mehl; Andrei Osterman; Pieter dorrestein
The biosynthesis of nicotinamide adenine dinucleotides in bacteria.
Vitamins and hormones 2001;61():103-19.
2001: Matthew D Daugherty; Veronika Vonstein; Ross Overbeek; Andrei Osterman
Archaeal shikimate kinase, a new member of the GHMP-kinase family.
Journal of bacteriology 2001;183(1):292-300.
2000: Tianjun Zhou; Matthew D Daugherty; Nick V Grishin; Andrei Osterman; Hong Zhang
Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.
Structure (London, England : 1993) 2000;8(12):1247-57.
2000: Laurie K Jackson; Harold B Brooks; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Biochemistry 2000;39(37):11247-57.
1999: Nick V Grishin; Andrei Osterman; Harold B Brooks; Margaret A Phillips; Elizabeth J Goldsmith
X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry 1999;38(46):15174-84.
1999: Andrei Osterman; Harold B Brooks; L Jackson; Jared J Abbott; Margaret A Phillips
Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps.
Biochemistry 1999;38(36):11814-26.
1998: T Swanson; Harold B Brooks; Andrei Osterman; M H O'Leary; Margaret A Phillips
Carbon-13 isotope effect studies of Trypanosoma brucei ornithine decarboxylase.
Biochemistry 1998;37(42):14943-7.
1997: Andrei Osterman; Harold B Brooks; Josep Rizo; Margaret A Phillips
Role of Arg-277 in the binding of pyridoxal 5'-phosphate to Trypanosoma brucei ornithine decarboxylase.
Biochemistry 1997;36(15):4558-67.
1996: Nick V Grishin; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Crystallization and preliminary X-ray studies of ornithine decarboxylase from Trypanosoma brucei.
Proteins 1996;24(2):272-3.
1995: Andrei Osterman; D V Lueder; M Quick; D Myers; BJ Canagarajah; Margaret A Phillips
Domain organization and a protease-sensitive loop in eukaryotic ornithine decarboxylase.
Biochemistry 1995;34(41):13431-6.
1995: Andrei Osterman; L N Kinch; Nick V Grishin; Margaret A Phillips
Acidic residues important for substrate binding and cofactor reactivity in eukaryotic ornithine decarboxylase identified by alanine scanning mutagenesis.
The Journal of biological chemistry 1995;270(20):11797-802.
1994: Andrei Osterman; Nick V Grishin; L N Kinch; Margaret A Phillips
Formation of functional cross-species heterodimers of ornithine decarboxylase.
Biochemistry 1994;33(46):13662-7.