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Arne Ostman

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Cristina Peña; Roger R Reddel; Per Sandström; Tobias Sjöblom; Srinivas Veerla; Martin Augsten; Helgi Birgisson; Linda Bojmar; María Virtudes Céspedes; Andy C-M Chang; Per-Henrik Edqvist; Alberto Gallardo; Christina Hägglöf; Karin Jirström; Sara Kiflemariam; Maja Bradic Lindh; Bafalluy Mangues; Artur Mezheyeuski; Eleonor Olsson; Arne Ostman
STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.
Karolina Edlund; Simon Ekman; Hanna Göransson-Kultima; Lars Holmberg; Anders Isaksson; Karin Jirström; Leif Johansson; Mats Lambe; Kristina Lamberg; Per Landelius; Cecilia Lindskog; Fredrik Nyberg; Arne Ostman; Maria Planck; Fredrik Pontén; Akira Saito; Anders Berglund; Michael Bergqvist; Johan Botling; Patrick Micke
CD99 is a novel prognostic stromal marker in non-small cell lung cancer.
Arne Ostman
The tumor microenvironment controls drug sensitivity.

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2013: Cristina Peña; Roger R Reddel; Per Sandström; Tobias Sjöblom; Srinivas Veerla; Martin Augsten; Helgi Birgisson; Linda Bojmar; María Virtudes Céspedes; Andy C-M Chang; Per-Henrik Edqvist; Alberto Gallardo; Christina Hägglöf; Karin Jirström; Sara Kiflemariam; Maja Bradic Lindh; Bafalluy Mangues; Artur Mezheyeuski; Eleonor Olsson; Arne Ostman
STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.
Cancer research 2013;73(4):1287-97.
2012: Karolina Edlund; Simon Ekman; Hanna Göransson-Kultima; Lars Holmberg; Anders Isaksson; Karin Jirström; Leif Johansson; Mats Lambe; Kristina Lamberg; Per Landelius; Cecilia Lindskog; Fredrik Nyberg; Arne Ostman; Maria Planck; Fredrik Pontén; Akira Saito; Anders Berglund; Michael Bergqvist; Johan Botling; Patrick Micke
CD99 is a novel prognostic stromal marker in non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2012;131(10):2264-73.
2012: Arne Ostman
The tumor microenvironment controls drug sensitivity.
Nature medicine 2012;18(9):1332-4.
2012: Rinesh Godfrey; Theresa Heinrich; Jörg P Müller; Ulf Schnetzke; Sebastian Scholl; Sabine Stopp; Arne Ostman; Deepika Arora; Reinhard Bauer; Sylvia-Annette Böhmer; Markus Dagnell; Frank-D Böhmer
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
Blood 2012;119(19):4499-511.
2012: Carina Strell; Helene Rundqvist; Arne Ostman
Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis.
Upsala journal of medical sciences 2012;117(2):187-95.
2011: daniel hägerstrand; Xiaobing He; Göran Hesselager; Saskia Hoefs; Maja Bradic Lindh; Arne Ostman; Monica Nistér
Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile.
Neuro-oncology 2011;13(11):1178-91.
2011: Arne Ostman; Asa Sandin; Jeroen Frijhoff; Frank-D Böhmer
Regulation of protein tyrosine phosphatases by reversible oxidation.
Journal of biochemistry 2011;150(4):345-56.
2011: Asa Sandin; Markus Dagnell; Adrian T Gonon; John Pernow; Verena Stangl; Pontus Aspenström; Kai Kappert; Arne Ostman
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases.
Cellular signalling 2011;23(5):820-6.
2011: Henrik ten Freyhaus; Markus Dagnell; Maike Leuchs; Marius Vantler; Eva M Berghausen; Evren Caglayan; Norbert Weissmann; Bhola K Dahal; Ralph T Schermuly; Arne Ostman; Kai Kappert; Stephan Rosenkranz
Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.
American journal of respiratory and critical care medicine 2011;183(8):1092-102.
2011: Janna Paulsson; Maja Bradic Lindh; Malin Jarvius; Marjut Puputti; Monica Nistér; Nina N Nupponen; Werner Paulus; Ola Söderberg; Gregor Dresemann; Andreas von Deimling; Heikki Joensuu; Arne Ostman; Martin Hasselblatt
Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma.
International journal of cancer. Journal international du cancer 2011;128(8):1981-8.
2011: Sara Jonmarker Jaraj; Martin Augsten; Lars Häggarth; Kenneth Wester; Fredrik Pontén; Arne Ostman; Lars Egevad
GAD1 is a biomarker for benign and malignant prostatic tissue.
Scandinavian journal of urology and nephrology 2011;45(1):39-45.
2011: Lars Häggarth; Christina Hägglöf; Sara Jonmarker Jaraj; Kenneth Wester; Fredrik Pontén; Arne Ostman; Lars Egevad
Diagnostic biomarkers of prostate cancer.
Scandinavian journal of urology and nephrology 2011;45(1):60-7.
2010: Marcus Conrad; Asa Sandin; Heidi Förster; Alexander Seiler; Jeroen Frijhoff; Markus Dagnell; Georg W Bornkamm; Olof Rådmark; Rob Hooft van Huijsduijnen; Pontus Aspenström; Frank Böhmer; Arne Ostman
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15774-9.
2010: Andrea Uecker; Marit Sicker; Thomas Beckers; Siavosh Mahboobi; daniel hägerstrand; Arne Ostman; Frank-D Böhmer
Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents.
Anti-cancer drugs 2010;21(8):759-65.
2010: Arne Ostman
[Intensive search for agents that knock out tumor growth].
Läkartidningen 2010;107(16):1066-70.
2010: Roy-Akira Saito; Patrick Micke; Janna Paulsson; Martin Augsten; Cristina Peña; Per Jönsson; Johan Botling; Karolina Edlund; Leif Johansson; Peter Carlsson; Karin Jirström; Kohei Miyazono; Arne Ostman
Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.
Cancer research 2010;70(7):2644-54.
2010: Martin Augsten; Christina Hägglöf; Cristina Peña; Arne Ostman
A digest on the role of the tumor microenvironment in gastrointestinal cancers.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2010;3(1):167-76.
2010: Christina Hägglöf; Peter Hammarsten; AM Josefsson; Pär Stattin; Janna Paulsson; Anders Bergh; Arne Ostman
Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival.
PloS one 2010;5(5):e10747.
2010: Carina Hellberg; Arne Ostman; Carl-Henrik Heldin
PDGF and vessel maturation.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2010;180():103-14.
2009: Björn Koos; Janna Paulsson; Malin Jarvius; Betzabe Chavez Sanchez; Brigitte Wrede; Sonja Mertsch; Astrid Jeibmann; Anne Kruse; Ove Peters; Johannes Ernst Wolff; Hans-Joachim Galla; Ola Söderberg; Werner Paulus; Arne Ostman; Martin Hasselblatt
Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.
The American journal of pathology 2009;175(4):1631-7.
2009: Janna Paulsson; Tobias Sjöblom; Patrick Micke; Fredrik Pontén; Göran Landberg; Carl-Henrik Heldin; Jonas Bergh; Donal J Brennan; Karin Jirström; Arne Ostman
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
The American journal of pathology 2009;175(1):334-41.
2009: Patrick Micke; Daniel Hackbusch; Sibel Mercan; Philipp Stawowy; Oleg Tsuprykov; Thomas Unger; Arne Ostman; Kai Kappert
Regulation of tyrosine phosphatases in the adventitia during vascular remodelling.
Biochemical and biophysical research communications 2009;382(4):678-84.
2009: Martin Augsten; Christina Hägglöf; Eleonor Olsson; Claudia Stolz; Panagiotis Tsagozis; Tetyana Levchenko; Mitchell J Frederick; Ake Borg; Patrick Micke; Lars Egevad; Arne Ostman
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3414-9.
2009: Kristian Wennmalm; Arne Ostman; Jonas Bergh
Stromal signature identifies basal breast cancers.
Nature medicine 2009;15(3):237-8; author reply 238.
2009: Arne Ostman; Martin Augsten
Cancer-associated fibroblasts and tumor growth--bystanders turning into key players.
Current opinion in genetics & development 2009;19(1):67-73.
2008: Sofi Forsberg; Arne Ostman; Ola Rollman
Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase.
Archives of dermatological research 2008;300(9):505-16.
2008: Luchezar Karagyozov; Rinesh Godfrey; Sylvia-Annette Böhmer; Astrid Petermann; Sebastian Hölters; Arne Ostman; Frank-D Böhmer
The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation.
Nucleic acids research 2008;36(13):4443-53.
2008: Simon P Robinson; Christian Ludwig; Janna Paulsson; Arne Ostman
The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI.
International journal of cancer. Journal international du cancer 2008;122(7):1548-56.
2008: Jeroen den Hertog; Arne Ostman; Frank-D Böhmer
Protein tyrosine phosphatases: regulatory mechanisms.
The FEBS journal 2008;275(5):831-47.
2008: Anna Asplund; M Gry Björklund; C Sundquist; Sara Strömberg; K Edlund; Arne Ostman; Peter Nilsson; Fredrik Pontén; Joakim Lundeberg
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
The British journal of dermatology 2008;158(3):527-38.
2008: Nina N Nupponen; Janna Paulsson; Astrid Jeibmann; Brigitte Wrede; Minna Tanner; Johannes Ernst Wolff; Werner Paulus; Arne Ostman; Martin Hasselblatt
Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(3):265-70.
2008: Frank Eitner; Eva Bücher; Claudia van Roeyen; Uta Kunter; Song Rong; Claudia Seikrit; Luigi Villa; Peter Boor; Linda Fredriksson; Gudrun Bäckström; Ulf Eriksson; Arne Ostman; Jürgen Floege; Tammo Ostendorf
PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN 2008;19(2):281-9.
2008: daniel hägerstrand; Anja Smits; Anna Eriksson; Sunna Sigurdardottir; Tommie Olofsson; Magdalena Hartman; Monica Nistér; Hannu Kalimo; Arne Ostman
Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker.
Neuro-oncology 2008;10(1):2-9.
2007: Yoko Hasumi; Agnieszka Kłosowska-Wardega; Masao Furuhashi; Arne Ostman; Carl-Henrik Heldin; Carina Hellberg
Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.
International journal of cancer. Journal international du cancer 2007;121(12):2606-14.
2007: Malin Jarvius; Janna Paulsson; Irene Weibrecht; Karl-Johan Leuchowius; Ann-Catrin Andersson; Carolina Wählby; Mats Gullberg; Johan Botling; Tobias Sjöblom; Boyka Markova; Arne Ostman; Ulf Landegren; Ola Söderberg
In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.
Molecular & cellular proteomics : MCP 2007;6(9):1500-9.
2007: Irene Weibrecht; Sylvia-Annette Böhmer; Markus Dagnell; Kai Kappert; Arne Ostman; Frank-D Böhmer
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.
Free radical biology & medicine 2007;43(1):100-10.
2007: Patrick Micke; Kai Kappert; Mitsuhiro Ohshima; Christina Sundquist; Stefan Scheidl; Per Lindahl; Carl-Henrik Heldin; Johan Botling; Fredrik Ponten; Arne Ostman
In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma.
The Journal of investigative dermatology 2007;127(6):1516-23.
2007: Kai Kappert; Janna Paulsson; Jan Sparwel; Olli Leppänen; Carina Hellberg; Arne Ostman; Patrick Micke
Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):523-34.
2006: Kai Kappert; Jan Sparwel; Asa Sandin; Alexander Seiler; Udo Siebolts; Olli Leppänen; Stephan Rosenkranz; Arne Ostman
Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2644-51.
2006: Kai Kappert; Olli Leppänen; Janna Paulsson; Masao Furuhashi; Mari-Anne Carlsson; Carl-Henrik Heldin; Gerd Fätkenheuer; Stephan Rosenkranz; Arne Ostman
Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury.
Journal of acquired immune deficiency syndromes (1999) 2006;43(4):383-92.
2006: Susann Karlsson; Katarzyna Kowanetz; Asa Sandin; Camilla Persson; Arne Ostman; Carl-Henrik Heldin; Carina Hellberg
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor.
Molecular biology of the cell 2006;17(11):4846-55.
2006: Kamal Balavenkatraman; Enrico Jandt; Karlheinz Friedrich; Tanja Kautenburger; Beatrice L Pool-Zobel; Arne Ostman; Frank-D Böhmer
DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients.
Oncogene 2006;25(47):6319-24.
2006: daniel hägerstrand; Göran Hesselager; S Achterberg; Ulrika Wickenberg-Bolin; M Kowanetz; M Kastemar; C-H Heldin; A Isaksson; Monica Nistér; Arne Ostman
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures.
Oncogene 2006;25(35):4913-22.
2006: Arne Ostman; Carina Hellberg; Frank-D Böhmer
Protein-tyrosine phosphatases and cancer.
Nature reviews. Cancer 2006;6(4):307-20.
2006: Patrick Micke; Mitsuhiro Ohshima; Simin Tahmasebpoor; Zhi-Ping Ren; Arne Ostman; Fredrik Pontén; Johan Botling
Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens.
Laboratory investigation; a journal of technical methods and pathology 2006;86(2):202-11.
2005: Patrick Micke; Arne Ostman
Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.
Expert opinion on therapeutic targets 2005;9(6):1217-33.
2005: Janina Baranowska-Kortylewicz; Michio Abe; Kristian Pietras; Zbigniew P Kortylewicz; Takashi Kurizaki; Jessica Nearman; Janna Paulsson; R Lee Mosley; Charles A Enke; Arne Ostman
Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy.
Cancer research 2005;65(17):7824-31.
2005: Arnoud Groen; Simone Lemeer; Thea van der Wijk; John Overvoorde; albert heck; Arne Ostman; David Barford; Monique Slijper; Jeroen den Hertog
Differential oxidation of protein-tyrosine phosphatases.
The Journal of biological chemistry 2005;280(11):10298-304.
2005: Kai Kappert; Kevin G Peters; Frank-D Böhmer; Arne Ostman
Tyrosine phosphatases in vessel wall signaling.
Cardiovascular research 2005;65(3):587-98.
2005: Patrick Micke; Arne Ostman; Joakim Lundeberg; Fredrik Ponten
Laser-assisted cell microdissection using the PALM system.
Methods in molecular biology (Clifton, N.J.) 2005;293():151-66.
2005: Camilla Persson; Kai Kappert; Ulla Engström; Arne Ostman; Tobias Sjöblom
An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases.
Methods (San Diego, Calif.) 2005;35(1):37-43.
2004: Carl-Henrik Heldin; Kristofer Rubin; Kristian Pietras; Arne Ostman
High interstitial fluid pressure - an obstacle in cancer therapy.
Nature reviews. Cancer 2004;4(10):806-13.
2004: Patrick Micke; Arne Ostman
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
Lung cancer (Amsterdam, Netherlands) 2004;45 Suppl 2():S163-75.
2004: Masao Furuhashi; Tobias Sjöblom; Alexandra Abramsson; Jens Ellingsen; Patrick Micke; Hong Li; Erika Bergsten-Folestad; Ulf Eriksson; Rainer Heuchel; Christer Betsholtz; Carl-Henrik Heldin; Arne Ostman
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
Cancer research 2004;64(8):2725-33.
2004: Olli Leppänen; Juha Rutanen; Mikko O Hiltunen; Tuomas T Rissanen; Mikko Turunen; Tobias Sjöblom; Josef Brüggen; Gudrun Bäckström; Marianne Carlsson; Elisabeth Buchdunger; David Bergqvist; Kari Alitalo; Carl-Henrik Heldin; Arne Ostman; Seppo Ylä-Herttuala
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Camilla Persson; Catrine Sävenhed; Annie Bourdeau; Michel L Tremblay; Boyka Markova; Frank-D Böhmer; Fawaz G Haj; Benjamin G Neel; Ari Elson; Carl-Henrik Heldin; Lars Rönnstrand; Arne Ostman; Carina Hellberg
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Molecular and cellular biology 2004;24(5):2190-201.
2004: Camilla Persson; Tobias Sjöblom; Arnoud Groen; Kai Kappert; Ulla Engström; Ulf Hellman; Carl-Henrik Heldin; Jeroen den Hertog; Arne Ostman
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1886-91.
2004: Tobias Sjöblom; Ihor Yakymovych; Carl-Henrik Heldin; Arne Ostman; Serhiy Souchelnytskyi
Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice.
European journal of cancer (Oxford, England : 1990) 2004;40(2):267-74.
2004: Patrick Micke; Tone Bjørnsen; Stefan Scheidl; Sara Strömberg; Jean-Baptiste Demoulin; Fredrik Ponten; Arne Ostman; Per Lindahl; Christer Busch
A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting.
The Journal of pathology 2004;202(1):130-8.
2003: Kristian Pietras; Michael Stumm; Martine Hubert; Elisabeth Buchdunger; Kristofer Rubin; Carl-Henrik Heldin; Paul M J McSheehy; Markus Wartmann; Arne Ostman
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3779-87.
2003: Per Lindblom; Holger Gerhardt; Stefan Liebner; Alexandra Abramsson; Maria Enge; Mats Hellstrom; Gudrun Backstrom; Simon Fredriksson; Ulf Landegren; Henrik C Nystrom; Goran Bergstrom; Elisabetta Dejana; Arne Ostman; Per Lindahl; Christer Betsholtz
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Genes & development 2003;17(15):1835-40.
2003: Annica Pontén; Xuri Li; Peter Thorén; Karin Aase; Tobias Sjöblom; Arne Ostman; Ulf Eriksson
Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy.
The American journal of pathology 2003;163(2):673-82.
2003: Enrico Jandt; Karsten Denner; Marina Kovalenko; Arne Ostman; Frank-D Böhmer
The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion.
Oncogene 2003;22(27):4175-85.
2003: Kristian Pietras; Tobias Sjöblom; Kristofer Rubin; Carl-Henrik Heldin; Arne Ostman
PDGF receptors as cancer drug targets.
Cancer cell 2003;3(5):439-43.
2003: Ola Rollman; Uffe B Jensen; Arne Ostman; Lars Bolund; Sigrún M Gústafsdóttir; Thomas G Jensen
Platelet derived growth factor (PDGF) responsive epidermis formed from human keratinocytes transduced with the PDGF beta receptor gene.
The Journal of investigative dermatology 2003;120(5):742-9.
2003: Aviv Gazit; Kevin W H Yee; Andrea Uecker; Frank-D Böhmer; Tobias Sjöblom; Arne Ostman; Johannes Waltenberger; Gershon Golomb; Shmuel Banai; Michael C Heinrich; Alexander Levitzki
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.
Bioorganic & medicinal chemistry 2003;11(9):2007-18.
2002: Renhai Cao; Ebba Brakenhielm; Xuri Li; Kristian Pietras; Johan Widenfalk; Arne Ostman; Ulf Eriksson; Yuhai Cao
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1575-83.
2002: Kristian Pietras; Kristofer Rubin; Tobias Sjöblom; Elisabeth Buchdunger; Mats Sjöquist; Carl-Henrik Heldin; Arne Ostman
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Cancer research 2002;62(19):5476-84.
2002: Simon Fredriksson; Mats Gullberg; Jonas Jarvius; Charlotta Olsson; Kristian Pietras; Sigrún M Gústafsdóttir; Arne Ostman; Ulf Landegren
Protein detection using proximity-dependent DNA ligation assays.
Nature biotechnology 2002;20(5):473-7.
2002: Camilla Persson; Ulla Engström; Sherry L Mowbray; Arne Ostman
Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.
FEBS letters 2002;517(1-3):27-31.
2002: Carl-Henrik Heldin; Ulf Eriksson; Arne Ostman
New members of the platelet-derived growth factor family of mitogens.
Archives of biochemistry and biophysics 2002;398(2):284-90.
2001: M Sörby; J Sandström; Arne Ostman
An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1.
Oncogene 2001;20(37):5219-24.
2001: Tobias Sjöblom; A Shimizu; Kevin P O'Brien; Kristian Pietras; P Dal Cin; Elisabeth Buchdunger; Jan P Dumanski; Arne Ostman; Carl-Henrik Heldin
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.
Cancer research 2001;61(15):5778-83.
2001: A Shimizu; Camilla Persson; Carl-Henrik Heldin; Arne Ostman
Ligand stimulation reduces platelet-derived growth factor beta-receptor susceptibility to tyrosine dephosphorylation.
The Journal of biological chemistry 2001;276(30):27749-52.
2001: E Bergsten; Marko Uutela; Xuri Li; Kristian Pietras; Arne Ostman; Carl-Henrik Heldin; Kari Alitalo; Ulf Eriksson
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Nature cell biology 2001;3(5):512-6.
2001: Kristian Pietras; Arne Ostman; Mats Sjöquist; Elisabeth Buchdunger; Rolf K Reed; Carl-Henrik Heldin; Kristofer Rubin
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.
Cancer research 2001;61(7):2929-34.
2001: Arne Ostman; Carl-Henrik Heldin
Involvement of platelet-derived growth factor in disease: development of specific antagonists.
Advances in cancer research 2001;80():1-38.
2000: Helena Larsson; Tobias Sjöblom; Johan Dixelius; Arne Ostman; K Ylinenjärvi; Ingemar Björk; Lena Claesson-Welsh
Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells.
Cancer research 2000;60(23):6723-9.
2000: Olli Leppänen; Nebojsa Janjic; M A Carlsson; Kristian Pietras; M Levin; C Vargeese; LS Green; David Bergqvist; Arne Ostman; Carl-Henrik Heldin
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E89-95.
2000: Marina Kovalenko; K Denner; J Sandström; Camilla Persson; S Gross; Enrico Jandt; R Vilella; Frank-D Böhmer; Arne Ostman
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.
The Journal of biological chemistry 2000;275(21):16219-26.
2000: Xuri Li; Annica Pontén; Karin Aase; Linda Karlsson; Alexandra Abramsson; Marko Uutela; Gudrun Bäckström; Mats Hellström; Hans Boström; Hong Li; P Soriano; Christer Betsholtz; Carl-Henrik Heldin; Kari Alitalo; Arne Ostman; Ulf Eriksson
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Nature cell biology 2000;2(5):302-9.
2000: Olli Leppänen; K Miyazawa; Gudrun Bäckström; Kristian Pietras; Tobias Sjöblom; Carl-Henrik Heldin; Arne Ostman
Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency.
Biochemistry 2000;39(9):2370-5.
2000: Lene Uhrbom; Göran Hesselager; Arne Ostman; Monica Nistér; Bengt Westermark
Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells.
International journal of cancer. Journal international du cancer 2000;85(3):398-406.
1999: Tobias Sjöblom; anthony boureux; Lars Rönnstrand; Carl-Henrik Heldin; Jacques Ghysdael; Arne Ostman
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein.
Oncogene 1999;18(50):7055-62.
1999: A Shimizu; Kevin P O'Brien; Tobias Sjöblom; Kristian Pietras; Elisabeth Buchdunger; V P Collins; Carl-Henrik Heldin; Jan P Dumanski; Arne Ostman
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.
Cancer research 1999;59(15):3719-23.
1998: K Miyazawa; Gudrun Bäckström; Olli Leppänen; C Persson; C Wernstedt; U Hellman; Carl-Henrik Heldin; Arne Ostman
Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly.
The Journal of biological chemistry 1998;273(39):25495-502.
1998: Carl-Henrik Heldin; Arne Ostman; Lars Rönnstrand
Signal transduction via platelet-derived growth factor receptors.
Biochimica et biophysica acta 1998;1378(1):F79-113.
1997: Adila El-Obeid; Erik Bongcam-Rudloff; M Sörby; Arne Ostman; Monica Nistér; Bengt Westermark
Cell scattering and migration induced by autocrine transforming growth factor alpha in human glioma cells in vitro.
Cancer research 1997;57(24):5598-604.
1997: T Omura; K Miyazawa; Arne Ostman; Carl-Henrik Heldin
Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.
The Journal of biological chemistry 1997;272(37):23317-22.
1997: T Omura; Carl-Henrik Heldin; Arne Ostman
Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization.
The Journal of biological chemistry 1997;272(19):12676-82.
1996: M Afrakhte; Monica Nistér; Arne Ostman; Bengt Westermark; Y Paulsson
Production of cell-associated PDGF-AA by a human sarcoma cell line: evidence for a latent autocrine effect.
International journal of cancer. Journal international du cancer 1996;68(6):802-9.
1996: Carl-Henrik Heldin; Arne Ostman
Ligand-induced dimerization of growth factor receptors: variations on the theme.
Cytokine & growth factor reviews 1996;7(1):3-10.
1996: J Kreysing; Arne Ostman; M van de Poll; G Bäckström; Carl-Henrik Heldin
Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors.
FEBS letters 1996;385(3):181-4.
1996: M Sörby; Arne Ostman
Protein-tyrosine phosphatase-mediated decrease of epidermal growth factor and platelet-derived growth factor receptor tyrosine phosphorylation in high cell density cultures.
The Journal of biological chemistry 1996;271(18):10963-6.
1995: M Andersson; Arne Ostman; J Kreysing; G Bäckström; M Van de Poll; Carl-Henrik Heldin
Involvement of loop 2 of platelet-derived growth factor-AA and -BB in receptor binding.
Growth factors (Chur, Switzerland) 1995;12(2):159-64.
1994: Flemming S Vassbotn; Arne Ostman; Nina Langeland; Holm Holmsen; Bengt Westermark; Carl-Henrik Heldin; Monica Nistér
Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line.
Journal of cellular physiology 1994;158(2):381-9.
1994: M Andersson; Arne Ostman; Bengt Westermark; Carl-Henrik Heldin
Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain.
The Journal of biological chemistry 1994;269(2):926-30.
1994: M Pekny; Arne Ostman; A Hermansson; Monica Nistér; Carl-Henrik Heldin; Bengt Westermark
Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor.
Growth factors (Chur, Switzerland) 1994;10(2):77-87.
1993: Flemming S Vassbotn; M Andersson; Bengt Westermark; Carl-Henrik Heldin; Arne Ostman
Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.
Molecular and cellular biology 1993;13(7):4066-76.
1993: Arne Ostman; M Andersson; G Bäckström; Carl-Henrik Heldin
Assignment of intrachain disulfide bonds in platelet-derived growth factor B-chain.
The Journal of biological chemistry 1993;268(18):13372-7.
1993: Carl-Henrik Heldin; Arne Ostman; Bengt Westermark
Structure of platelet-derived growth factor: implications for functional properties.
Growth factors (Chur, Switzerland) 1993;8(4):245-52.
1992: Flemming S Vassbotn; Arne Ostman; Agneta Siegbahn; Holm Holmsen; Carl-Henrik Heldin
Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types.
The Journal of biological chemistry 1992;267(22):15635-41.
1992: Arne Ostman; J Thyberg; Bengt Westermark; Carl-Henrik Heldin
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
The Journal of cell biology 1992;118(3):509-19.
1992: B Elliott; Arne Ostman; Bengt Westermark; Kristofer Rubin
Modulation of growth factor responsiveness of murine mammary carcinoma cells by cell matrix interactions: correlation of cell proliferation and spreading.
Journal of cellular physiology 1992;152(2):292-301.
1992: M Andersson; Arne Ostman; G Bäckström; Ulf Hellman; C George-Nascimento; Bengt Westermark; Carl-Henrik Heldin
Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF.
The Journal of biological chemistry 1992;267(16):11260-6.
1992: Carl-Henrik Heldin; Arne Ostman; A Eriksson; Agneta Siegbahn; Lena Claesson-Welsh; Bengt Westermark
Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes.
Kidney international 1992;41(3):571-4.
1991: Arne Ostman; M Andersson; C Betsholtz; Bengt Westermark; Carl-Henrik Heldin
Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.
Cell regulation 1991;2(7):503-12.
1991: Arne Ostman; M Andersson; Ulf Hellman; Carl-Henrik Heldin
Identification of three amino acids in the platelet-derived growth factor (PDGF) B-chain that are important for binding to the PDGF beta-receptor.
The Journal of biological chemistry 1991;266(16):10073-7.
1990: Johan Thyberg; Arne Ostman; G Bäckström; Bengt Westermark; Carl-Henrik Heldin
Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: retention of PDGF-BB in the endoplasmic reticulum and Golgi complex.
Journal of cell science 1990;97 ( Pt 2)():219-29.
1989: Arne Ostman; G Bäckström; N Fong; Christer Betsholtz; Christer Wernstedt; Ulf Hellman; Bengt Westermark; P Valenzuela; Carl-Henrik Heldin
Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities.
Growth factors (Chur, Switzerland) 1989;1(3):271-81.
1988: Arne Ostman; L Rall; A Hammacher; M A Wormstead; D Coit; P Valenzuela; Christer Betsholtz; Bengt Westermark; Carl-Henrik Heldin
Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.
The Journal of biological chemistry 1988;263(31):16202-8.
1988: A Hammacher; Ulf Hellman; A Johnsson; Arne Ostman; K Gunnarsson; Bengt Westermark; A Wasteson; Carl-Henrik Heldin
A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.
The Journal of biological chemistry 1988;263(31):16493-8.
1988: Lena Claesson-Welsh; A Eriksson; A Morén; L Severinsson; B Ek; Arne Ostman; C Betsholtz; Carl-Henrik Heldin
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
Molecular and cellular biology 1988;8(8):3476-86.
1988: Carl-Henrik Heldin; G Bäckström; Arne Ostman; A Hammacher; Lars Rönnstrand; K Rubin; Monica Nistér; Bengt Westermark
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.
The EMBO journal 1988;7(5):1387-93.
1987: Lars Rönnstrand; M P Beckmann; B Faulders; Arne Ostman; B Ek; C H Heldin
Purification of the receptor for platelet-derived growth factor from porcine uterus.
The Journal of biological chemistry 1987;262(7):2929-32.