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Kinya Otsu

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Anatomy

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Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
Osamu Yamaguchi; Manabu Taneike; Kinya Otsu
Cooperation between proteolytic systems in cardiomyocyte recycling.
Takafumi Oka; Shizuo Akira; Shungo Hikoso; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Jota Oyabu; Toshihiro Takeda; Takahito Tamai; Manabu Taneike; Osamu Yamaguchi; Akitsugu Yamamoto; Kinya Otsu
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.

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All Publications

2013: Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
The Journal of biological chemistry 2013;288(14):10176-87.
2012: Osamu Yamaguchi; Manabu Taneike; Kinya Otsu
Cooperation between proteolytic systems in cardiomyocyte recycling.
Cardiovascular research 2012;96(1):46-52.
2012: Takafumi Oka; Shizuo Akira; Shungo Hikoso; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Jota Oyabu; Toshihiro Takeda; Takahito Tamai; Manabu Taneike; Osamu Yamaguchi; Akitsugu Yamamoto; Kinya Otsu
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
Nature 2012;485(7397):251-5.
2011: Manabu Taneike; Tetsuya Watanabe; Osamu Yamaguchi; Jota Oyabu; Junji Takeda; Toshihiro Takeda; Takahito Tamai; Shungo Hikoso; Issei Komuro; Isamu Mizote; Naoki Mochizuki; Takashi Morita; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Calpain protects the heart from hemodynamic stress.
The Journal of biological chemistry 2011;286(37):32170-7.
2011: Jota Oyabu; Kinya Otsu
[Advancement in diagnosis of coronary artery disease].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 7():149-53.
2010: Manabu Taneike; Osamu Yamaguchi; Jota Oyabu; Takahiko Shimizu; Toshihiro Takeda; Takuji Shirasawa Takuji Shirasawa; Takahito Tamai; Shungo Hikoso; Masatsugu Hori; Issei Komuro; Isamu Mizote; Noboru Mizushima; Tomokazu Murakawa; Atsuko Nakai; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Autophagy 2010;6(5):600-6.
2010: Isamu Mizote; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Manabu Taneike; Takafumi Oka; Takahito Tamai; Jota Oyabu; Yasushi Matsumura; Kazuhiko Nishida; Issei Komuro; Masatsugu Hori; Kinya Otsu
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
Journal of molecular and cellular cardiology 2010;48(2):302-9.
2010: Norifumi Takeda; Ichiro Manabe; Yuichi Uchino; Kosei Eguchi; Sahohime Matsumoto; Satoshi Nishimura; Takayuki Shindo; Motoaki Sano; Kinya Otsu; Paige Snider; Simon J Conway; Ryozo Nagai
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
The Journal of clinical investigation 2010;120(1):254-65.
2009: Masako Ohno; Akiko Yamamoto; Ayumu Ono; Genta Miura; Masanobu Funamoto; Yasuhiko Takemoto; Kinya Otsu; Yasushi Kouno; Tomoko Tanabe; Yuiko Masunaga; Shinpei Nonen; Yasushi Fujio; Junichi Azuma
Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.
European journal of clinical pharmacology 2009;65(11):1097-103.
2009: Shungo Hikoso; Osamu Yamaguchi; Yuko Nakano; Toshihiro Takeda; Shigemiki Omiya; Isamu Mizote; Manabu Taneike; Takafumi Oka; Takahito Tamai; Jota Oyabu; Yoshihiro Uno; Yasushi Matsumura; Kazuhiko Nishida; Keiichiro Suzuki; Mikihiko Kogo; Masatsugu Hori; Kinya Otsu
The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.
Circulation research 2009;105(1):70-9.
2009: Tomohito Ohtani; Toshiaki Mano; Shungo Hikoso; Yasushi Sakata; Mayu Nishio; Yasuharu Takeda; Kinya Otsu; Takeshi Miwa; Tohru Masuyama; Masatsugu Hori; Kazuhiro Yamamoto
Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.
Journal of hypertension 2009;27(5):1074-83.
2008: Tetsuya Watanabe; Toshihiro Takeda; Shigemiki Omiya; Shungo Hikoso; Osamu Yamaguchi; Yuko Nakano; Yoshiharu Higuchi; Atsuko Nakai; Yusuke Abe; Yayoi Aki-Jin; Masako Taniike; Isamu Mizote; Yasushi Matsumura; Takahiko Shimizu; Kazuhiko Nishida; Kiyohiro Imai; Masatsugu Hori; Takuji Shirasawa; Kinya Otsu
Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.
Journal of the American College of Cardiology 2008;52(9):779-86.
2008: Kazuhiko Nishida; Osamu Yamaguchi; Kinya Otsu
Crosstalk between autophagy and apoptosis in heart disease.
Circulation research 2008;103(4):343-51.
2008: Masako Taniike; Osamu Yamaguchi; Ikuko Tsujimoto; Shungo Hikoso; Toshihiro Takeda; Atsuko Nakai; Shigemiki Omiya; Isamu Mizote; Yuko Nakano; Yoshiharu Higuchi; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy.
Circulation 2008;117(4):545-52.
2008: Kazuhiko Nishida; Kinya Otsu
Cell death in heart failure.
Circulation journal : official journal of the Japanese Circulation Society 2008;72 Suppl A():A17-21.
2007: Shungo Hikoso; Ikeda Yasuhiro; Osamu Yamaguchi; Toshihiro Takeda; Yoshiharu Higuchi; Shinichi Hirotani; Kazunori Kashiwase; Michio Yamada; Michio Asahi; Yasushi Matsumura; Kazuhiko Nishida; Masunori Matsuzaki; Masatsugu Hori; Kinya Otsu
Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer.
Journal of the American College of Cardiology 2007;50(5):453-62.
2007: Atsuko Nakai; Osamu Yamaguchi; Toshihiro Takeda; Yoshiharu Higuchi; Shungo Hikoso; Masako Taniike; Shigemiki Omiya; Isamu Mizote; Yasushi Matsumura; Michio Asahi; Kazuhiko Nishida; Masatsugu Hori; Noboru Mizushima; Kinya Otsu
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Nature medicine 2007;13(5):619-24.
2006: Kazuhiko Nishida; Kinya Otsu
The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis.
Antioxidants & redox signaling 2006;8(9-10):1729-36.
2006: Koichi Inoue; Hiroshi Ito; Katsuomi Iwakura; Shigeo Kawano; Atsunori Okamura; Toshiya Kurotobi; Motoo Date; Kinya Otsu; Masatsugu Hori; Kenshi Fujii
Usefulness of high-resolution real-time three-dimensional echocardiography to visualize the left ventricular endocardial surface in myocardial infarction.
The American journal of cardiology 2006;97(11):1578-81.
2006: Hiroki Kato; Osamu Takeuchi; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Kosuke Matsui; Satoshi Uematsu; Andreas Jung; Taro Kawai; Ken J Ishii; Osamu Yamaguchi; Kinya Otsu; Tohru Tsujimura; Chang-Sung Koh; Caetano Reis e Sousa; Yoshiharu Matsuura; Takashi Fujita; Shizuo Akira
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature 2006;441(7089):101-5.
2006: Hiroya Mizuno; Hiroshi Sato; Yasuhiko Sakata; Yozo Ohnishi; Eiji Hishida; Kunihiro Kinjo; Daisaku Nakatani; Masahiko Shimizu; Hiroya Kondo; Toshihiro Tanaka; Kouichi Ozaki; Atsushi Hirayama; Hiroshi Ito; Kinya Otsu; Masatsugu Hori
Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.
Atherosclerosis 2006;185(2):400-5.
2005: Toshihiro Takeda; Michio Asahi; Osamu Yamaguchi; Shungo Hikoso; Hiroyuki Nakayama; Yoichiro Kusakari; Makoto Kawai; Kenichi Hongo; Yoshiharu Higuchi; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Kazuhiko Nishida; Satoshi Kurihara; Dorit B Donoviel; alan bernstein; Taisuke Tomita; Takeshi Iwatsubo; Masatsugu Hori; Kinya Otsu
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2069-71.
2005: Toshihiro Takeda; Kinya Otsu; Masatsugu Hori
[Calcium channel blocker and cardiac hypertrophy].
Clinical calcium 2005;15(10):1645-9.
2005: Tetsuya Watanabe; Kinya Otsu; Toshihiro Takeda; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Yoshiharu Higuchi; Masako Taniike; Atsuko Nakai; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
Biochemical and biophysical research communications 2005;333(2):562-7.
2005: Ikuko Tsujimoto; Shungo Hikoso; Osamu Yamaguchi; Kazunori Kashiwase; Atsuko Nakai; Toshihiro Takeda; Tetsuya Watanabe; Masako Taniike; Yasushi Matsumura; Kazuhiko Nishida; Masatsugu Hori; Mikihiko Kogo; Kinya Otsu
The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.
Hypertension 2005;45(5):921-6.
2005: Kazunori Kashiwase; Yoshiharu Higuchi; Shinichi Hirotani; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Hikaru Ueno; Kazuhiko Nishida; Masatsugu Hori; Kinya Otsu
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Biochemical and biophysical research communications 2005;327(1):136-42.
2005: Kunihiro Kinjo; Hiroshi Sato; Yasuhiko Sakata; Daisaku Nakatani; Hiroya Mizuno; Masahiko Shimizu; Tatsuya Sasaki; Yoshiyuki Kijima; Masami Nishino; Masaaki Uematsu; Jun Tanouchi; Shinsuke Nanto; Kinya Otsu; Masatsugu Hori
Impact of smoking status on long-term mortality in patients with acute myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(1):7-12.
2004: A Russell Tupling; Anthony O Gramolini; Todd A Duhamel; Hiroya Kondo; Michio Asahi; Shauna C Tsuchiya; Michael J Borrelli; James R Lepock; Kinya Otsu; Masatsugu Hori; David H MacLennan; Howard J Green
HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA1a) and prevents thermal inactivation.
The Journal of biological chemistry 2004;279(50):52382-9.
2004: Tetsuya Watanabe; Kinya Otsu
[Signal transduction in heart failure].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(12):2337-42.
2004: Kazuhiko Nishida; Osamu Yamaguchi; Shinichi Hirotani; Shungo Hikoso; Yoshiharu Higuchi; Tetsuya Watanabe; Toshihiro Takeda; Osuka Soh; Takashi Morita; Gen Kondoh; Yoshihiro Uno; Kazunori Kashiwase; Masako Taniike; Atsuko Nakai; Yasushi Matsumura; Jun-ichi Miyazaki; Tatsuhiko Sudo; Kenichi Hongo; Yoichiro Kusakari; Satoshi Kurihara; Kenneth R Chien; Junji Takeda; Masatsugu Hori; Kinya Otsu
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Molecular and cellular biology 2004;24(24):10611-20.
2004: Shungo Hikoso; Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Toshihiro Takeda; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Ikuko Tsujimoto; Michio Asahi; Yasushi Matsumura; Kazuhiko Nishida; Hiroshi Nakajima; Shizuo Akira; Masatsugu Hori; Kinya Otsu
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Circulation 2004;110(17):2631-7.
2004: Osamu Yamaguchi; Tetsuya Watanabe; Kazuhiko Nishida; Kazunori Kashiwase; Yoshiharu Higuchi; Toshihiro Takeda; Shungo Hikoso; Shinichi Hirotani; Michio Asahi; Masako Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Jun-ichi Miyazaki; Kenneth R Chien; Atsushi Matsuzawa; Chiharu Sadamitsu; Hidenori Ichijo; Manuela Baccarini; Masatsugu Hori; Kinya Otsu
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
The Journal of clinical investigation 2004;114(7):937-43.
2004: Michio Asahi; Kinya Otsu; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Anthony O Gramolini; Maria G Trivieri; Gavin Y Oudit; Takashi Morita; Yoichiro Kusakari; Shuta Hirano; Kenichi Hongo; Shinichi Hirotani; Osamu Yamaguchi; Alan Peterson; Peter H Backx; Satoshi Kurihara; Masatsugu Hori; David H MacLennan
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9199-204.
2004: Shinichi Hirotani; Yoshiharu Higuchi; Kazuhiko Nishida; Hiroyuki Nakayama; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Kazunori Kashiwase; Tetsuya Watanabe; Michio Asahi; Masako Taniike; Ikuko Tsujimoto; Yasushi Matsumura; Terukatsu Sasaki; Masatsugu Hori; Kinya Otsu
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
Journal of molecular and cellular cardiology 2004;36(6):799-807.
2004: Yoichiro Kusakari; Shuta Hirano; Kenichi Hongo; Hiroyuki Nakayama; Kinya Otsu; Satoshi Kurihara
[The mechanism of contractile dysfunction in heart failure, focussing on SERCA2a function].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;123(2):87-93.
2003: Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Kazunori Kashiwase; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Michio Asahi; Masako Taniike; Yasushi Matsumura; Ikuko Tsujimoto; Kenichi Hongo; Yoichiro Kusakari; Satoshi Kurihara; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15883-8.
2003: Yasushi Sakata; Kazuhiro Yamamoto; Toshiaki Mano; Nagahiro Nishikawa; Junichi Yoshida; Hiroyuki Nakayama; Kinya Otsu; Keiichiro Suzuki; Michihiko Tada; Masatsugu Hori; Takeshi Miwa; Tohru Masuyama
Angiotensin II type 1 receptor blockade prevents diastolic heart failure through modulation of Ca(2+) regulatory proteins and extracellular matrix.
Journal of hypertension 2003;21(9):1737-45.
2003: Toshihiro Takeda; Shiro Hoshida; Masami Nishino; Jun Tanouchi; Kinya Otsu; Masatsugu Hori
Relationship between effects of statins, aspirin and angiotensin II modulators on high-sensitive C-reactive protein levels.
Atherosclerosis 2003;169(1):155-8.
2003: Yoshiharu Higuchi; Kinya Otsu; Kazuhiko Nishida; Shinichi Hirotani; Hiroyuki Nakayama; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Toshihiro Takeda; Tetsuya Watanabe; Toshiaki Mano; Yasushi Matsumura; Hikaru Ueno; Masatsugu Hori
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
The Journal of biological chemistry 2003;278(23):20770-7.
2003: Michio Asahi; Hiroyuki Nakayama; Michihiko Tada; Kinya Otsu
Regulation of sarco(endo)plasmic reticulum Ca2+ adenosine triphosphatase by phospholamban and sarcolipin: implication for cardiac hypertrophy and failure.
Trends in cardiovascular medicine 2003;13(4):152-7.
2003: Kinya Otsu; Nobushige Yamashita; Kazuhiko Nishida; Shinichi Hirotani; Osamu Yamaguchi; Tetsuya Watanabe; Shungo Hikoso; Yoshiharu Higuchi; Yasushi Matsumura; Masumi Maruyama; Tatsuhiko Sudo; Hiroyuki Osada; Masatsugu Hori
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.
Biochemical and biophysical research communications 2003;302(1):56-60.
2003: Hiroyuki Nakayama; Kinya Otsu; Osamu Yamaguchi; Kazuhiko Nishida; Moto-o Date; Kenichi Hongo; Yoichiro Kusakari; Toshihiko Toyofuku; Shungo Hikoso; Kazunori Kashiwase; Toshihiro Takeda; Yasushi Matsumura; Satoshi Kurihara; Masatsugu Hori; Michihiko Tada
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):61-3.
2002: Shiro Hoshida; Nobushige Yamashita; Kinya Otsu; Masatsugu Hori
Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats.
Journal of the American College of Cardiology 2002;40(4):826-31.
2002: Shiro Hoshida; Nobushige Yamashita; Kinya Otsu; Masatsugu Hori
The importance of manganese superoxide dismutase in delayed preconditioning: involvement of reactive oxygen species and cytokines.
Cardiovascular research 2002;55(3):495-505.
2002: Moto-o Date; Takashi Morita; Nobushige Yamashita; Kazuhiko Nishida; Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Yasushi Matsumura; Masatsugu Hori; Michihiko Tada; Kinya Otsu
The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model.
Journal of the American College of Cardiology 2002;39(5):907-12.
2002: Yoshiharu Higuchi; Kinya Otsu; Kazuhiko Nishida; Shinichi Hirotani; Hiroyuki Nakayama; Osamu Yamaguchi; Yasushi Matsumura; Hikaru Ueno; Michihiko Tada; Masatsugu Hori
Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy.
Journal of molecular and cellular cardiology 2002;34(2):233-40.
2002: Shinichi Hirotani; Kinya Otsu; Kazuhiko Nishida; Yoshiharu Higuchi; Takashi Morita; Hiroyuki Nakayama; Osamu Yamaguchi; Toshiaki Mano; Yasushi Matsumura; Hikaru Ueno; Michihiko Tada; Masatsugu Hori
Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy.
Circulation 2002;105(4):509-15.
2001: T Morita; Kinya Otsu; Masatsugu Hori
[Ca2+ -induced cell injury of cardiomyocyte].
Clinical calcium 2001;11(6):714-8.
2001: Yasushi Matsumura; E Saeki; Kinya Otsu; T Morita; H Takeda; Tsunehiko Kuzuya; Masatsugu Hori; Hideo Kusuoka
Intracellular calcium level required for calpain activation in a single myocardial cell.
Journal of molecular and cellular cardiology 2001;33(6):1133-42.
2000: Shiro Hoshida; N Yamashita; Kinya Otsu; M Hori
FR167653, a cytokine-suppressive agent, reduces myocardial ischemia-reperfusion injury in rats.
Cytokines, cellular & molecular therapy 2000;6(4):165-70.
2000: Yasushi Sakata; Tohru Masuyama; Kazuhiro Yamamoto; Nagahiro Nishikawa; H Yamamoto; H Kondo; Keiko Ono; Kinya Otsu; Tsunehiko Kuzuya; Takeshi Miwa; Hiroshi Takeda; E Miyamoto; Masatsugu Hori
Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats.
Circulation 2000;102(18):2269-75.
2000: N Yamashita; Shiro Hoshida; Kinya Otsu; N Taniguchi; Tsunehiko Kuzuya; Masatsugu Hori
The involvement of cytokines in the second window of ischaemic preconditioning.
British journal of pharmacology 2000;131(3):415-22.
2000: Nobushige Yamashita; Shiro Hoshida; Kinya Otsu; Naoyuki Taniguchi; Tsunehiko Kuzuya; Masatsugu Hori
Involvement of cytokines in the mechanism of whole-body hyperthermia-induced cardioprotection.
Circulation 2000;102(4):452-7.
2000: Moto-o Date; Kinya Otsu; Kazuhiko Nishida; Toshihiko Toyofuku; Yasushi Matsumura; Takashi Morita; Shinichi Hirotani; Y Okazaki; Y Hayashizaki; V Nigro; Tsunehiko Kuzuya; Michihiko Tada; Masatsugu Hori
Single-strand conformation polymorphism analysis on the delta-sarcoglycan gene in Japanese patients with hypertrophic cardiomyopathy.
The American journal of cardiology 2000;85(11):1315-8.
2000: Moto-o Date; Kinya Otsu; Tsunehiko Kuzuya; Masatsugu Hori
[Animal models of cardiomyopathy].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(1):233-9.
2000: Shiro Hoshida; N Yamashita; Kinya Otsu; Tsunehiko Kuzuya; Masatsugu Hori
Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats.
American journal of physiology. Heart and circulatory physiology 2000;278(1):H256-62.
1999: Toshihiko Toyofuku; Masanori Yabuki; Kinya Otsu; Tsunehiko Kuzuya; M Tada; Masatsugu Hori
Functional role of c-Src in gap junctions of the cardiomyopathic heart.
Circulation research 1999;85(8):672-81.
1999: N Yamashita; Shiro Hoshida; Kinya Otsu; N Taniguchi; Tsunehiko Kuzuya; Masatsugu Hori
Monophosphoryl lipid A provides biphasic cardioprotection against ischaemia-reperfusion injury in rat hearts.
British journal of pharmacology 1999;128(2):412-8.
1999: N Yamashita; Shiro Hoshida; Kinya Otsu; M Asahi; T Kuzuya; Masatsugu Hori
Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation.
The Journal of experimental medicine 1999;189(11):1699-706.
1998: Masanori Yabuki; Toshihiko Toyofuku; Kinya Otsu; M Nishida; Tsunehiko Kuzuya; Masatsugu Hori; M Tada
Involvement of NF-Y in transcriptional regulation of the phospholamban gene.
European journal of biochemistry / FEBS 1998;258(2):744-51.
1998: Kinya Otsu
[Malignant hyperthermia].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(12 Suppl):1898-902.
1998: Toshihiko Toyofuku; Masanori Yabuki; Kinya Otsu; Tsunehiko Kuzuya; Masatsugu Hori; M Tada
Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes.
The Journal of biological chemistry 1998;273(21):12725-31.
1998: Toshihiko Toyofuku; Masanori Yabuki; Kinya Otsu; Tsunehiko Kuzuya; Masatsugu Hori; M Tada
Intercellular calcium signaling via gap junction in connexin-43-transfected cells.
The Journal of biological chemistry 1998;273(3):1519-28.
1996: K Nishida; Kinya Otsu; Masatsugu Hori; Tsunehiko Kuzuya; M Tada
Cloning and characterization of the 5'-upstream regulatory region of the Ca(2+)-release channel gene of cardiac sarcoplasmic reticulum.
European journal of biochemistry / FEBS 1996;240(2):408-15.
1994: Kinya Otsu; K Nishida; Y Kimura; Tsunehiko Kuzuya; Masatsugu Hori; T Kamada; M Tada
The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia.
The Journal of biological chemistry 1994;269(13):9413-5.
1992: J Fujii; Kinya Otsu
[Mutations in the gene responsible for malignant hyperthermia].
Seikagaku. The Journal of Japanese Biochemical Society 1992;64(9):1129-33.