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Tom Ottenhoff

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Roelof A de Paus; Sangkot Marzuki; Tom H M Ottenhoff; Guus F Rimmelzwaan; Edhyana Sahiratmadja; Ruud van Beek; Reinout van Crevel; Alisjahbana Bachti; Jaap T van Dissel; Esther van de Vosse
The influence of influenza virus infections on the development of tuberculosis.
Susanna Commandeur; Karin Dijkman; Gregory Dolganov; Kees L M C Franken; Annemieke H Friggen; Annemieke Geluk; Gro Ellen Korsvold; Igor Kramnik; Fredrik Oftung; Alexander V Pichugin; Corine Prins; Gary K Schoolnik; Susan J F van den Eeden; Krista E van Meijgaarden; Tom H M Ottenhoff
An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.
Annemieke Geluk; Karin Dijkman; Kees L M C Franken; Susan J F van den Eeden; Krista E van Meijgaarden; Tom H M Ottenhoff
A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice.

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All Publications

2013: Roelof A de Paus; Sangkot Marzuki; Tom H M Ottenhoff; Guus F Rimmelzwaan; Edhyana Sahiratmadja; Ruud van Beek; Reinout van Crevel; Alisjahbana Bachti; Jaap T van Dissel; Esther van de Vosse
The influence of influenza virus infections on the development of tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2013;93(3):338-42.
2013: Susanna Commandeur; Karin Dijkman; Gregory Dolganov; Kees L M C Franken; Annemieke H Friggen; Annemieke Geluk; Gro Ellen Korsvold; Igor Kramnik; Fredrik Oftung; Alexander V Pichugin; Corine Prins; Gary K Schoolnik; Susan J F van den Eeden; Krista E van Meijgaarden; Tom H M Ottenhoff
An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1659-71.
2012: Annemieke Geluk; Karin Dijkman; Kees L M C Franken; Susan J F van den Eeden; Krista E van Meijgaarden; Tom H M Ottenhoff
A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice.
Vaccine 2012;30(52):7513-21.
2012: Desta Kassa; Tsehaynesh Messele; Tom H M Ottenhoff; Leonie Ran; Alemayehu Selase; Mekashaw Tebeje; Belete Tegbaru; Amelewerk Alemu; Kees L M C Franken; Annemieke H Friggen; Wudneh Geberemeskel; Krista E van Meijgaarden; Dawit Wolday; Debbie Van Baarle
Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis.
Clinical and vaccine immunology : CVI 2012;19(12):1907-15.
2012: Edith N G Houben; Connie R Jiménez; Joen Luirink; Tom H M Ottenhoff; Sander R Piersma; Roy Ummels; Louis Wilson; Jovanka Bestebroer; Wilbert Bitter
Composition of the type VII secretion system membrane complex.
Molecular microbiology 2012;86(2):472-84.
2012: Tom H M Ottenhoff
New pathways of protective and pathological host defense to mycobacteria.
Trends in microbiology 2012;20(9):419-28.
2012: Tolu Oni; Tom H M Ottenhoff; Ronnett Seldon; Relebohile Tsekela; Katalin A Wilkinson; Nonzwakazi Bangani; Hannah Priyadarshini Gideon; Rene T Goliath; Kathryn Wood; Robert J Wilkinson
Risk factors associated with indeterminate gamma interferon responses in the assessment of latent tuberculosis infection in a high-incidence environment.
Clinical and vaccine immunology : CVI 2012;19(8):1243-7.
2012: Eileen Png; Edhyana Sahiratmadja; Reinout van Crevel; Esther van de Vosse; Iskandar Adnan; Alisjahbana Bachti; Martin Hibberd; Sangkot Marzuki; Ron Nelwan; Tom H M Ottenhoff; Mark Seielstad
Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2012;12(6):1319-23.
2012: Emanuela Greco; Cinzia Marcantonio; Angelo Martino; Giuseppe Maulucci; Roberto Nisini; Tom H M Ottenhoff; Massimiliano Papi; Gianluca Quintiliani; Marilina B Santucci; Loredana Sarmati; Nigel D Savage; Annalucia Serafino; Mario Alma; Alfonso Altieri; Massimo Andreoni; Nadia Caccamo; Anna Rita Ciccaglione; Marco De Spirito; Giovanni Delogu; Diana Di Liberto; Francesco Dieli; Delia Goletti; Maurizio Fraziano
Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):E1360-8.
2012: Annemieke Geluk; Hee Jin Kim; Abraham Aseffa; Sayera Banu; Yonas Bekele; Kidist Bobosha; Sang-Nae Cho; Hazel M Dockrell; Kees L M C Franken; Geraldo Pereira; Maria Cristina Vidal Pessolani; John S Spencer; Mohammad K M Uddin; Jolien J van der Ploeg-van Schip; Marcia V S B Martins; Sheikh Abdul Hadi; Tom H M Ottenhoff
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):4782-91.
2012: Tom H M Ottenhoff; Jerrold Jay Ellner; Stefan H E Kaufmann
Ten challenges for TB biomarkers.
Tuberculosis (Edinburgh, Scotland) 2012;92 Suppl 1():S17-20.
2012: Thorsten Thye; Reinout van Crevel; Esther van de Vosse; Fredrik O Vannberg; Alisjahbana Bachti; Yanina Balabanova; James Curtis; Francis Drobniewski; Christa Ehmen; John Gyapong; Adrian V S Hill; Philip C Hill; Rolf D Horstmann; Birgit Muntau; Sergey Nejentsev; Melanie Newport; Vladyslav Nikolayevskyy; Tom H M Ottenhoff; Ellis Owusu-Dabo; Gerd Ruge; Edhyana Sahiratmadja; Jürgen Sievertsen; Giorgio Sirugo; Christian G Meyer
Common variants at 11p13 are associated with susceptibility to tuberculosis.
Nature genetics 2012;44(3):257-9.
2012: Felipe Riaño; Mauricio Rojas; Krista E van Meijgaarden; Leonar Arroyo; Kees L M C Franken; Annemieke H Friggen; Luis F García; Tom H M Ottenhoff; Sara París; Luis F Barrera
T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.
Tuberculosis (Edinburgh, Scotland) 2012;92(2):148-59.
2012: Tolu Oni; Tom H M Ottenhoff; Ronnett Seldon; Relebohile Tsekela; Katalin A Wilkinson; Nonzwakazi Bangani; Hannah Priyadarshini Gideon; Rene T Goliath; Kathryn Wood; Robert J Wilkinson
Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa.
PloS one 2012;7(10):e47072.
2012: Tom H M Ottenhoff; Edhyana Sahiratmadja; Mark Seielstad; Reinout van Crevel; Esther van de Vosse; Hazel E E Wong; Ninghan Yang; Mingzi M Zhang; Alisjahbana Bachti; Ranjeeta Hari Dass; Chiea Chuen Khor; Sangkot Marzuki; Martin L Hibberd
Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.
PloS one 2012;7(9):e45839.
2012: Mario Songane; Esther van de Vosse; Alisjahbana Bachti; Leo A B Joosten; Johanneke Kleinnijenhuis; Mihai G Netea; Marije Oosting; Tom H M Ottenhoff; Ida Parwati; Theo S Plantinga; Edhyana Sahiratmadja; Reinout van Crevel
Polymorphisms in autophagy genes and susceptibility to tuberculosis.
PloS one 2012;7(8):e41618.
2012: Novel N Chegou; Paulin N Essone; Kees L M C Franken; Stefan H E Kaufmann; Michel R Klein; Andre G Loxton; Tom H M Ottenhoff; Shreemanta K Parida; Kim Stanley; Gian D van der Spuy; Paul D van Helden; Gillian F Black; Gerhard Walzl
Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area.
PloS one 2012;7(6):e38501.
2012: Tom H M Ottenhoff; Stefan H E Kaufmann
Vaccines against tuberculosis: where are we and where do we need to go?
PLoS pathogens 2012;8(5):e1002607.
2012: Kidist Bobosha; Danuza A Esquenazi; Yonas Fantahun; Kees L M C Franken; Ronaldo C Gismondi; Marjorie M Guimarães; Marcia V Martins; Tom H M Ottenhoff; Geraldo Pereira; Maria Cristina Vidal Pessolani; Jolien J van der Ploeg-van Schip; Abraham Aseffa; Yonas Bekele; Annemieke Geluk
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls.
Journal of tropical medicine 2012;2012():132049.
2012: Anne M van der Does; Jaap T van Dissel; Krista E van Meijgaarden; Evy Vroomans; Sylvia J P Bogaards; Simone A Joosten; Tom H M Ottenhoff; Peter H Nibbering
The antimicrobial peptide hLF1-11 drives monocyte-dendritic cell differentiation toward dendritic cells that promote antifungal responses and enhance Th17 polarization.
Journal of innate immunity 2012;4(3):284-92.
2011: Kidist Bobosha; Kees L M C Franken; Abraham Aseffa; Deanna A Hagge; Wondmagegn Inbiale; Tom H M Ottenhoff; Bishwa Sapkota; Jolien J Van Der Ploeg-Van Schip; Martha Zewdie; Annemieke Geluk
Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa.
Leprosy review 2011;82(4):445-58.
2011: Tom H M Ottenhoff
New insights and tools to combat leprosy nerve damage.
Leprosy review 2011;82(4):334-7.
2011: Myrra G Carstens; Joke A Bouwstra; Cornelis J Melief; Ferry Ossendorp; Tom H M Ottenhoff; Koen van der Maaden; Daniel van der Velden; Wim Jiskoot
Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes.
Journal of liposome research 2011;21(4):286-95.
2011: Stephen T Reece; Sandra Schommer-Leitner; Maik Stein; Ulrike Zedler; Peter Andersen; Jes Dietrich; Ali Nasser-Eddine; Tom H M Ottenhoff; Stefan H E Kaufmann
Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens.
Vaccine 2011;29(47):8740-4.
2011: Abdallah Musa Abdallah; Jovanka Bestebroer; Wilbert Bitter; Karin de Punder; Cees J Korbee; Tom H M Ottenhoff; Nigel D L Savage; Astrid van der Sar; Nicole N Van Der Wel; Maaike van Zon; Louis Wilson; Peter J Peters
Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4744-53.
2011: Paul Corstjens; Claudia J de Dood; Tom H M Ottenhoff; Terhi Riuttamäki; John S Spencer; Hans J Tanke; Jolien J van der Ploeg-van Schip; Krista E van Meijgaarden; Karien C Wiesmeijer; Annemieke Geluk
Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.
Clinical biochemistry 2011;44(14-15):1241-6.
2011: Susanna Commandeur; Jan W Drijfhout; Kees L M C Franken; Annemieke H Friggen; Annemieke Geluk; Gro Ellen Korsvold; May Y Lin; Fredrik Oftung; Krista E van Meijgaarden; Tom H M Ottenhoff
Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals.
European journal of immunology 2011;41(10):2925-36.
2011: Annemieke Geluk; Hee Jin Kim; Karin Dijkman; Kees L M C Franken; Geraldo Pereira; Maria Cristina Vidal Pessolani; John S Spencer; Susan J F van den Eeden; Louis Wilson; Tom H M Ottenhoff
ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1393-402.
2011: Tolu Oni; Tom H M Ottenhoff; Ronnett Seldon; Relebohile Tsekela; Katalin A Wilkinson; Nonzwakazi Bangani; Rachael Burke; Hannah Priyadarshini Gideon; Kathryn Wood; Robert J Wilkinson
High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening.
Thorax 2011;66(8):669-73.
2011: Lian Ni Lee; Tom H M Ottenhoff; Edward O Ronan; Elma Z Tchilian; Catherine de Lara; Kees L M C Franken; Peter C L Beverley
CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis.
Infection and immunity 2011;79(8):3328-37.
2011: Myrra G Carstens; Kees L M C Franken; Malou Henriksen-Lacey; Joke A Bouwstra; Marcel G M Camps; Ferry Ossendorp; Tom H M Ottenhoff; Yvonne Perrie; Wim Jiskoot
Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines.
Vaccine 2011;29(29-30):4761-70.
2011: Susanna Commandeur; Krista E van Meijgaarden; May Young Lin; Kees L M C Franken; Annemieke H Friggen; Jan Wouter Drijfhout; Fredrik Oftung; Gro Ellen Korsvold; Annemieke Geluk; Tom H M Ottenhoff
Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals.
Clinical and vaccine immunology : CVI 2011;18(4):676-83.
2011: Jaap T van Dissel; Darius Soonawala; Simone A Joosten; Corine Prins; Sandra M Arend; Peter Bang; Pernille Nyholm Tingskov; Karen Lingnau; Jan Nouta; Søren T Hoff; Ida Rosenkrands; Ingrid Kromann; Tom H M Ottenhoff; Timothy Doherty; Peter Andersen
Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection.
Vaccine 2011;29(11):2100-9.
2011: Sheila Tuyet Tang; Krista E van Meijgaarden; Nadia Caccamo; Giuliana Guggino; Michèl R Klein; Pascale van Weeren; Fatima Kazi; Anette Stryhn; Alexander Zaigler; Ugur Sahin; Søren Buus; Francesco Dieli; Ole Lund; Tom H M Ottenhoff
Genome-based in silico identification of new Mycobacterium tuberculosis antigens activating polyfunctional CD8+ T cells in human tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1068-80.
2011: Elma Z Tchilian; Martin H Vordermeier; Catherine de Lara; Kees L M C Franken; Lian Ni Lee; Tom H M Ottenhoff; Edward O Ronan; Peter C L Beverley
Simultaneous immunization against tuberculosis.
PloS one 2011;6(11):e27477.
2011: Teresa Chiacchio; Gilda Cuzzi; Kees L M C Franken; Enrico Girardi; Francesco Nicola Lauria; Giuseppe Matteucci; Tom H M Ottenhoff; Linda Petrone; Elisa Petruccioli; Valentina Vanini; Ornella Butera; Delia Goletti
Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood.
PloS one 2011;6(11):e27539.
2011: Jayne S Sutherland; Tom H M Ottenhoff; Richard A Adegbola; I M O Adetifa; Bouke C de Jong; Simon A Donkor; Marielle C Haks; Philip C Hill; Simone A Joosten; Lizet Opmeer; Martin O C Ota
Identification of probable early-onset biomarkers for tuberculosis disease progression.
PloS one 2011;6(9):e25230.
2011: Ralph Carvalho; Jan de Sonneville; Oliver W Stockhammer; Nigel D L Savage; Wouter J Veneman; Tom H M Ottenhoff; Ron P Dirks; Annemarie H Meijer; Herman P Spaink
A high-throughput screen for tuberculosis progression.
PloS one 2011;6(2):e16779.
2010: Tom H M Ottenhoff; T Mark Doherty; Jaap T van Dissel; Peter Bang; Karen Lingnau; Ingrid Kromann; Peter Andersen
First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses.
Human vaccines 2010;6(12):1007-15.
2010: Thorbald van Hall; Claudia C Oliveira; Simone A Joosten; Tom H M Ottenhoff
The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress.
Microbes and infection / Institut Pasteur 2010;12(12-13):910-8.
2010: Marina D Kraaij; Nigel D L Savage; Sandra W van der Kooij; Karin Koekkoek; Jun Wang; J Merlijn van den Berg; Tom H M Ottenhoff; Taco W Kuijpers; Rikard Holmdahl; Cees van Kooten; Kyra A Gelderman
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17686-91.
2010: Ana Márcia M Mattos; Caroline de S Almeida; Kees L M C Franken; Caio César de S Alves; Clarice Abramo; Maria Aparecida de Souza; Marcos L'Hotellier; Márcio J M Alves; Ana Paula Ferreira; Sérgio C Oliveira; Tom H M Ottenhoff; Henrique C Teixeira
Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy.
International immunology 2010;22(9):775-82.
2010: Minka van Dongen; Nigel D L Savage; Ekaterina S. Jordanova; Inge H Briaire-de Bruijn; Kimberley V Walburg; Tom H M Ottenhoff; Pancras C W Hogendoorn; Sjoerd H van der burg; Hans Gelderblom; Thorbald van Hall
Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.
International journal of cancer. Journal international du cancer 2010;127(4):899-909.
2010: Simone A Joosten; Tom H M Ottenhoff
Comment on "CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infections".
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1351; author reply 1352.
2010: Anne M van der Does; Henry Beekhuizen; Bep Ravensbergen; Tim Vos; Tom H M Ottenhoff; Jaap T van Dissel; Jan W Drijfhout; Pieter S Hiemstra; Peter H Nibbering
LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1442-9.
2010: Nadia Caccamo; Giuliana Guggino; Simone A Joosten; Giuseppe Gelsomino; Paola Di Carlo; Lucina Titone; Domenico Galati; Marialuisa Bocchino; Alessandro Matarese; Alfredo Salerno; Alessandro Sanduzzi; Willeke P J Franken; Tom H M Ottenhoff; Francesco Dieli
Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection.
European journal of immunology 2010;40(8):2211-20.
2010: Annemieke Geluk; Jolien J van der Ploeg-van Schip; Krista E van Meijgaarden; Susanna Commandeur; Jan W Drijfhout; Willemien E Benckhuijsen; Kees L M C Franken; Bernard Naafs; Tom H M Ottenhoff
Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays.
Clinical and vaccine immunology : CVI 2010;17(6):993-1004.
2010: Jaap T van Dissel; Sandra M Arend; Corine Prins; Peter Bang; Pernille Nyholm Tingskov; Karen Lingnau; Jan Nouta; Michèl R Klein; Ida Rosenkrands; Tom H M Ottenhoff; Ingrid Kromann; Timothy Doherty; Peter Andersen
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.
Vaccine 2010;28(20):3571-81.
2010: Ida Parwati; Bachti Alisjahbana; Lika Apriani; Rista D Soetikno; Tom H M Ottenhoff; Adri G M van der Zanden; Jos van der Meer; Dick Van Soolingen; Reinout van Crevel
Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia.
The Journal of infectious diseases 2010;201(4):553-7.
2010: Simone A Joosten; Krista E van Meijgaarden; Pascale C van Weeren; Fatima Kazi; Annemieke Geluk; Nigel D L Savage; Jan W Drijfhout; Darren R Flower; Willem A Hanekom; Michèl R Klein; Tom H M Ottenhoff
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
PLoS pathogens 2010;6(2):e1000782.
2009: Reinout van Crevel; Ida Parwati; Edhyana Sahiratmadja; Sangkot Marzuki; Tom H M Ottenhoff; Mihai G Netea; Andre J A M van der Ven; R H H Nelwan; Jos W van der Meer; Alisjahbana Bachti; Esther van de Vosse
Infection with Mycobacterium tuberculosis Beijing genotype strains is associated with polymorphisms in SLC11A1/NRAMP1 in Indonesian patients with tuberculosis.
The Journal of infectious diseases 2009;200(11):1671-4.
2009: May Young Lin; T B K Reddy; Sandra M Arend; Annemieke H Friggen; Kees L M C Franken; Krista E van Meijgaarden; Marleen J C Verduyn; Gary K Schoolnik; Michel Klein; Tom H M Ottenhoff
Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria.
Infection and immunity 2009;77(11):5071-9.
2009: Tom H M Ottenhoff
Overcoming the global crisis: "yes, we can", but also for TB ... ?
European journal of immunology 2009;39(8):2014-20.
2009: Gillian F Black; Bonnie A Thiel; Martin O Ota; Shreemanta K Parida; Richard Adegbola; W Henry Boom; Hazel M Dockrell; Kees L M C Franken; Annemiek H Friggen; Philip C Hill; Michel R Klein; Maeve K Lalor; Harriet Mayanja; Gary Schoolnik; Kim Stanley; Karin Weldingh; Stefan H E Kaufmann; Gerhard Walzl; Tom H M Ottenhoff
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
Clinical and vaccine immunology : CVI 2009;16(8):1203-12.
2009: Johanneke Kleinnijenhuis; Leo A B Joosten; Frank van de Veerdonk; Nigel Savage; Reinout van Crevel; Bart Jan Kullberg; Andre van der Ven; Tom H M Ottenhoff; Charles A Dinarello; Jos W M van der Meer; Mihai G Netea
Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.
European journal of immunology 2009;39(7):1914-22.
2009: Maytal Bivas-Benita; May Young Lin; Suzanne M Bal; Krista E van Meijgaarden; Kees L M C Franken; Annemieke H Friggen; Hans E Junginger; Gerrit Borchard; Michèl R Klein; Tom H M Ottenhoff
Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice.
Vaccine 2009;27(30):4010-7.
2009: Sandra M Arend; Dick Van Soolingen; Tom H M Ottenhoff
Diagnosis and treatment of lung infection with nontuberculous mycobacteria.
Current opinion in pulmonary medicine 2009;15(3):201-8.
2009: Steven G Smith; Simone A Joosten; Virginie Verscheure; Ansar A Pathan; Helen McShane; Tom H M Ottenhoff; Hazel M Dockrell; Françoise Mascart
Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.
PloS one 2009;4(11):e7972.
2009: Sebastian D Schuck; Henrik Mueller; Frank Kunitz; Albert Neher; Harald Hoffmann; Kees L C M Franken; Dirk Repsilber; Tom H M Ottenhoff; Stefan H E Kaufmann; Marc Jacobsen
Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection.
PloS one 2009;4(5):e5590.
2009: Nadia Caccamo; Giuliana Guggino; Serena Meraviglia; Giuseppe Gelsomino; Paola Di Carlo; Lucina Titone; Marialuisa Bocchino; Domenico Galati; Alessandro Matarese; Jan Nouta; Michel R Klein; Alfredo Salerno; Alessandro Sanduzzi; Francesco Dieli; Tom H M Ottenhoff
Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection.
PloS one 2009;4(5):e5528.
2009: Frank A W Verreck; Richard A W Vervenne; Ivanela Kondova; Klaas W van Kralingen; Edmond J Remarque; Gerco Braskamp; Nicole M van der Werff; Ariena Kersbergen; Tom H M Ottenhoff; Peter J Heidt; Sarah C Gilbert; Brigitte Gicquel; Adrian V S Hill; Carlos Martin; Helen McShane; Alan W Thomas
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.
PloS one 2009;4(4):e5264.
2008: Abdallah Musa Abdallah; Nigel D L Savage; Maaike van Zon; Louis Wilson; Christina M.J.E, Vandenbroucke-Grauls; Nicole N van der Wel; Tom H M Ottenhoff; Wilbert Bitter
The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7166-75.
2008: Simone A Joosten; Tom H M Ottenhoff
Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination.
Human immunology 2008;69(11):760-70.
2008: Sonia Davila; Martin L Hibberd; Ranjeeta Hari Dass; Hazel E E Wong; Edhyana Sahiratmadja; Carine Bonnard; Alisjahbana Bachti; Jeffrey S Szeszko; Yanina Balabanova; Francis Drobniewski; Reinout van Crevel; Esther van de Vosse; Sergey Nejentsev; Tom H M Ottenhoff; Mark Seielstad
Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.
PLoS genetics 2008;4(10):e1000218.
2008: Nigel D L Savage; Tjitske de Boer; Kimberley V Walburg; Simone A Joosten; Krista E van Meijgaarden; Annemieke Geluk; Tom H M Ottenhoff
Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2220-6.
2008: Tjitske de Boer; Jaap T van Dissel; Taco W J Kuijpers; Guus F Rimmelzwaan; Frank P Kroon; Tom H M Ottenhoff
Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I.
Clinical and vaccine immunology : CVI 2008;15(8):1171-5.
2008: Willem A Hanekom; Hazel M Dockrell; Tom H M Ottenhoff; Timothy Doherty; Helen Fletcher; Helen McShane; Frank F Weichold; Dan F Hoft; Shreemanta K Parida; Uli J Fruth
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.
PLoS medicine 2008;5(7):e145.
2008: May Young Lin; Tom H M Ottenhoff
Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection.
Biological chemistry 2008;389(5):497-511.
2008: Paul Corstjens; Michel Zuiderwijk; Hans J Tanke; Jolien J van der Ploeg-van Schip; Tom H M Ottenhoff; Annemiek Geluk
A user-friendly, highly sensitive assay to detect the IFN-gamma secretion by T cells.
Clinical biochemistry 2008;41(6):440-4.
2008: May Young Lin; Tom H M Ottenhoff
Host-pathogen interactions in latent Mycobacterium tuberculosis infection: identification of new targets for tuberculosis intervention.
Endocrine, metabolic & immune disorders drug targets 2008;8(1):15-29.
2008: Sergey Nejentsev; Thorsten Thye; Jeffrey S Szeszko; Helen Stevens; Yanina Balabanova; Amanua M Chinbuah; Martin Hibberd; Esther van de Vosse; Alisjahbana Bachti; Reinout van Crevel; Tom H M Ottenhoff; Eileen Png; Francis Drobniewski; John A Todd; Mark Seielstad; Rolf D Horstmann
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
Nature genetics 2008;40(3):261-2; author reply 262-3.
2008: Annemieke Geluk; JD van der Ploeg; Rose O B Teles; Kees L M C Franken; Corine Prins; Jan Wouter Drijfhout; Euzenir N Sarno; Elizabeth P Sampaio; Tom H M Ottenhoff
Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.
Clinical and vaccine immunology : CVI 2008;15(3):522-33.
2008: Michelle I Portugal; Adriane R Todeschini; Cristiana S de Lima; Carlos A M Silva; Ronaldo Mohana-Borges; Tom H M Ottenhoff; Lucia Mendonça-Previato; José O Previato; Maria Cristina Vidal Pessolani
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp.
BMC microbiology 2008;8():75.
2007: Coenraad Kuijl; Nigel D L Savage; Marije Marsman; Adriaan W Tuin; Lennert Janssen; David A Egan; Mirjam Ketema; Rian van den Nieuwendijk; Susan J F van den Eeden; Annemieke Geluk; Alex Poot; Gijsbert A van der Marel; Roderick L Beijersbergen; Herman S Overkleeft; Tom H M Ottenhoff; Jacques Neefjes
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Nature 2007;450(7170):725-30.
2007: Gerben Ferwerda; Bart Jan Kullberg; Dirk J de Jong; Stephen E Girardin; Dennis M L Langenberg; Reinout van Crevel; Tom H M Ottenhoff; Jos W M van der Meer; Mihai G Netea
Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.
Journal of leukocyte biology 2007;82(4):1011-8.
2007: Edhyana Sahiratmadja; Frank T Wieringa; Reinout van Crevel; Adriëtte W de Visser; Iskandar Adnan; Alisjahbana Bachti; Eline Slagboom; Sangkot Marzuki; Tom H M Ottenhoff; Esther van de Vosse; Joannes Marx
Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population.
The British journal of nutrition 2007;98(4):684-90.
2007: Om Parkash; Ajay Kumar; Richa Pandey; Bhawneshwar Kumar Girdhar; Kees L M C Franken; Tom H M Ottenhoff
Serological heterogeneity against various Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients.
Journal of medical microbiology 2007;56(Pt 9):1259-61.
2007: Martin Vordermeier; Jemma Brown; Paul J Cockle; Willeke P J Franken; Jan Wouter Drijfhout; Sandra M Arend; Tom H M Ottenhoff; Keith Jahans; R Glyn Hewinson
Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level.
Clinical and vaccine immunology : CVI 2007;14(9):1203-9.
2007: Jeroen G Noordzij; Nico G Hartwig; Frank A W Verreck; Sandra de Bruin-Versteeg; Tjitske de Boer; Jaap T van Dissel; Ronald de Groot; Tom H M Ottenhoff; Jacques J M van Dongen
Two patients with complete defects in interferon gamma receptor-dependent signaling.
Journal of clinical immunology 2007;27(5):490-6.
2007: Alisjahbana Bachti; Edhyana Sahiratmadja; Erni J Nelwan; Anugrah Maya Purwa; Yana Ahmad; Tom H M Ottenhoff; R H H Nelwan; Ida Parwati; Jos W M van der Meer; Reinout van Crevel
The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(4):428-35.
2007: Om Parkash; Ajay Kumar; Richa Pandey; Kees L M C Franken; Tom H M Ottenhoff
Detection of Mycobacterium leprae infection employing a combinatorial approach of anti-45 kDa and modified anti-PGL-I antibody detection assays.
Journal of medical microbiology 2007;56(Pt 8):1129-30.
2007: Eliane M S Leyten; Sandra M Arend; Corine Prins; Frank G J Cobelens; Tom H M Ottenhoff; Jaap T van Dissel
Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation.
Clinical and vaccine immunology : CVI 2007;14(7):880-5.
2007: May Young Lin; Annemieke Geluk; Steven G Smith; Amanda L Stewart; Annemieke H Friggen; Kees L M C Franken; Marleen J C Verduyn; Krista E van Meijgaarden; Martin I Voskuil; Hazel M Dockrell; Kris Huygen; Tom H M Ottenhoff; Michel Klein
Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.
Infection and immunity 2007;75(7):3523-30.
2007: Edhyana Sahiratmadja; Renee Baak-Pablo; Adriëtte W de Visser; Alisjahbana Bachti; Iskandar Adnan; Reinout van Crevel; Sangkot Marzuki; Jaap T van Dissel; Tom H M Ottenhoff; Esther van de Vosse
Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia.
Tuberculosis (Edinburgh, Scotland) 2007;87(4):303-11.
2007: Edhyana Sahiratmadja; Alisjahbana Bachti; Simona Buccheri; Diana Di Liberto; Tjitske de Boer; Iskandar Adnan; Reinout van Crevel; Michel Klein; Krista E van Meijgaarden; R H H Nelwan; Esther van de Vosse; Francesco Dieli; Tom H M Ottenhoff
Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults.
Tuberculosis (Edinburgh, Scotland) 2007;87(4):312-21.
2007: Annemieke Geluk; May Young Lin; Krista E van Meijgaarden; Eliane M S Leyten; Kees L M C Franken; Tom H M Ottenhoff; Michel Klein
T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination.
Infection and immunity 2007;75(6):2914-21.
2007: Eliane M S Leyten; Corine Prins; Aik Bossink; S F T Thijsen; Tom H M Ottenhoff; Jaap T van Dissel; Sandra M Arend
Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-gamma assay.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(6):1212-6.
2007: Simone A Joosten; Krista E van Meijgaarden; Nigel D L Savage; Tjitske de Boer; Frédéric Triebel; Annemieke van der Wal; Emile de Heer; Michel Klein; Annemieke Geluk; Tom H M Ottenhoff
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8029-34.
2007: Virginie Roupie; Marta Romano; Lei Zhang; Hannelie Korf; May Young Lin; Kees L M C Franken; Tom H M Ottenhoff; Michel Klein; Kris Huygen
Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice.
Infection and immunity 2007;75(2):941-9.
2007: Edhyana Sahiratmadja; Alisjahbana Bachti; Tjitske de Boer; Iskandar Adnan; Anugrah Maya; Halim Danusantoso; R H H Nelwan; Sangkot Marzuki; Jos W M van der Meer; Reinout van Crevel; Esther van de Vosse; Tom H M Ottenhoff
Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment.
Infection and immunity 2007;75(2):820-9.
2007: Valérie Martinez; Guislaine Carcelain; Edgar Badell; Marc Jouan; Isabelle Mauger; Pierre Sellier; Chantal Truffot; François Bricaire; Sandra M Arend; Tom H M Ottenhoff; Brigitte Autran; Brigitte Gicquel
T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals.
BMC infectious diseases 2007;7():83.
2006: Om Parkash; Ajay Kumar; Astha Nigam; Kees L M C Franken; Tom H M Ottenhoff
Evaluation of recombinant serine-rich 45-kDa antigen (ML0411) for detection of antibodies in leprosy patients.
Scandinavian journal of immunology 2006;64(4):450-5.
2006: Mihai G Netea; Tania Azam; Eli C Lewis; Leo A B Joosten; Maorong Wang; Dennis Langenberg; Xianzhong Meng; Edward D Chan; Do-Young Yoon; Tom H M Ottenhoff; Soo-Hyun Kim; Charles A Dinarello
Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism.
PLoS medicine 2006;3(8):e277.
2006: Eliane M S Leyten; May Young Lin; Kees L M C Franken; Annemieke H Friggen; Corine Prins; Krista E van Meijgaarden; Martin I Voskuil; Karin Weldingh; Peter Andersen; Gary K Schoolnik; Sandra M Arend; Tom H M Ottenhoff; Michel Klein
Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.
Microbes and infection / Institut Pasteur 2006;8(8):2052-60.
2006: Alisjahbana Bachti; Reinout van Crevel; Edhyana Sahiratmadja; M den Heijer; A Maya; E Istriana; Halim Danusantoso; Tom H M Ottenhoff; R H H Nelwan; J W M Van Der Meer
Diabetes mellitus is strongly associated with tuberculosis in Indonesia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2006;10(6):696-700.
2006: Annemieke Geluk; Tom H M Ottenhoff
HLA and leprosy in the pre and postgenomic eras.
Human immunology 2006;67(6):439-45.
2006: Tom H M Ottenhoff
Introduction: new susceptibility genes in mycobacterial infectious diseases.
Microbes and infection / Institut Pasteur 2006;8(4):1117-8.
2006: Esther van de Vosse; Tom H M Ottenhoff
Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity.
Microbes and infection / Institut Pasteur 2006;8(4):1167-73.
2006: Eliane M S Leyten; Bert Mulder; Corine Prins; Karin Weldingh; Peter Andersen; Tom H M Ottenhoff; Jaap T van Dissel; Sandra M Arend
Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure.
Journal of clinical microbiology 2006;44(3):1197-201.
2006: Marieke A Hoeve; Nigel D L Savage; Tjitske de Boer; Dennis M L Langenberg; Rene de Waal Malefyt; Tom H M Ottenhoff; Frank A W Verreck
Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.
European journal of immunology 2006;36(3):661-70.
2006: Abebech Demissie; Eliane M S Leyten; Markos Abebe; Liya Wassie; Abraham Aseffa; Getahun Abate; Helen Fletcher; Patrick K Owiafe; Philip C Hill; Roger H Brookes; Graham Rook; Alimuddin Zumla; Sandra M Arend; Michel Klein; Tom H M Ottenhoff; Peter Andersen; T Mark Doherty
Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI 2006;13(2):179-86.
2006: Frank A W Verreck; Tjitske de Boer; Dennis M L Langenberg; Linda van der Zanden; Tom H M Ottenhoff
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.
Journal of leukocyte biology 2006;79(2):285-93.
2006: Ozden Sanal; Tuba Turul; Tjitske de Boer; Esther van de Vosse; Işik Yalcin; Ilhan Tezcan; Cağman Sun; Leyla Memis; Tom H M Ottenhoff; Fügen Ersoy
Presentation of interleukin-12/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections.
Journal of clinical immunology 2006;26(1):1-6.
2006: Clarice Abramo; Krista E Meijgaarden; Daniely Garcia; Kees L M C Franken; Michel Klein; Arend J Kolk; Sergio C Oliveira; Tom H M Ottenhoff; Henrique C Teixeira
Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients.
Microbes and infection / Institut Pasteur 2006;8(1):45-51.
2006: Nico J D Nagelkerke; Sake J de Vlas; Yodi Mahendradhata; Tom H M Ottenhoff; Martien Borgdorff
The search for a tuberculosis vaccine: an elusive quest?
Tuberculosis (Edinburgh, Scotland) 2006;86(1):41-6.
2005: John S Spencer; Hazel M Dockrell; Hee Jin Kim; Maria Angela M Marques; Diana L Williams; Marcia V S B Martins; Marcio L F Martins; Monica C B S Lima; Euzenir N Sarno; Geraldo Pereira; Haroldo J Matos; Leila S Fonseca; Elizabeth P Sampaio; Tom H M Ottenhoff; Annemieke Geluk; Sang-Nae Cho; neil stoker; Stewart T Cole; Patrick J Brennan; Maria Cristina Vidal Pessolani
Identification of specific proteins and peptides in Mycobacterium leprae suitable for the selective diagnosis of leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7930-8.
2005: Esther van de Vosse; Roelof A de Paus; Jaap T van Dissel; Tom H M Ottenhoff
Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency.
Human molecular genetics 2005;14(24):3847-55.
2005: Philip M D Wood; Claire Fieschi; Capucine Picard; Tom H M Ottenhoff; Jean-Laurent Casanova; Dinakantha S Kumararatne
Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children.
European journal of pediatrics 2005;164(12):741-7.
2005: Gerben Ferwerda; Stephen E Girardin; Bart Jan Kullberg; Lionel Le Bourhis; Dirk J de Jong; Dennis M L Langenberg; Reinout van Crevel; Gosse J Adema; Tom H M Ottenhoff; Jos W M van der Meer; Mihai G Netea
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.
PLoS pathogens 2005;1(3):279-85.
2005: Maytal Bivas-Benita; Tom H M Ottenhoff; Hans E Junginger; Gerrit Borchard
Pulmonary DNA vaccination: concepts, possibilities and perspectives.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(1):1-29.
2005: Tom H M Ottenhoff; Michel Klein
Leprosy bacillus triggers the wrong cells.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2005;73(3):208-10.
2005: Annemieke Geluk; Michel Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria Cristina Vidal Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.
Infection and immunity 2005;73(9):5636-44.
2005: A Fortes; Kelly Pereira; Paulo R Z Antas; C L M C Franken; M Dalcolmo; Marilza-Moura Ribeiro-Carvalho; Kátia S Cunha; Annemieke Geluk; Afranio L Kritski; A Kolk; Paul R Klatser; Euzenir N Sarno; Tom H M Ottenhoff; Elizabeth P Sampaio
Detection of in vitro interferon-gamma and serum tumour necrosis factor-alpha in multidrug-resistant tuberculosis patients.
Clinical and experimental immunology 2005;141(3):541-8.
2005: Paulo R Z Antas; Fernando L L Cardoso; Kelly Pereira; Kees L M C Franken; Kátia S Cunha; Paul R Klatser; Euzenir N Sarno; Tom H M Ottenhoff; Elizabeth P Sampaio
T cell immune responses to mycobacterial antigens in Brazilian tuberculosis patients and controls.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(9):699-707.
2005: Cristiana Soares de Lima; Laurence Zulianello; Maria Angela M Marques; Heejin Kim; Michelle Iespa Portugal; Sérgio Luiz Gomes Antunes; Franco D Menozzi; Tom H M Ottenhoff; Patrick J Brennan; Maria Cristina Vidal Pessolani
Mapping the laminin-binding and adhesive domain of the cell surface-associated Hlp/LBP protein from Mycobacterium leprae.
Microbes and infection / Institut Pasteur 2005;7(9-10):1097-109.
2005: Philip C Hill; Dolly Jackson-Sillah; Annette Fox; Kees L M C Franken; Moses D Lugos; David J Jeffries; Simon A Donkor; Abdulrahman Hammond; Richard A Adegbola; Tom H M Ottenhoff; Michel Klein; Roger H Brookes
ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia.
Journal of clinical microbiology 2005;43(5):2070-4.
2005: Tom H M Ottenhoff; Frank A W Verreck; Marieke A Hoeve; Esther van de Vosse
Control of human host immunity to mycobacteria.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):53-64.
2005: Mary Morgan; Jolanda H M van Bilsen; Aleida M Bakker; Bianca Heemskerk; Marco W Schilham; Franca C Hartgers; Berendina G Elferink; Linda van der Zanden; René R P De Vries; Tom W J Huizinga; Tom H M Ottenhoff; René E M Toes
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.
Human immunology 2005;66(1):13-20.
2005: Maaike E Ressing; Daphne van Leeuwen; Frank A W Verreck; Sinéad Keating; Raquel Gomez; Kees L M C Franken; Tom H M Ottenhoff; Melanie Spriggs; Schumacher Ton; Lindsey M Hutt-Fletcher; Martin Rowe; Emmanuel J H J Wiertz
Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.
Journal of virology 2005;79(2):841-52.
2004: Esther van de Vosse; Marieke A Hoeve; Tom H M Ottenhoff
Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae.
The Lancet infectious diseases 2004;4(12):739-49.
2004: Jeroen Van Bergen; Allan Thompson; Arno R van der Slik; Tom H M Ottenhoff; Jacobijn Gussekloo; Frits Koning
Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6719-26.
2004: Calman MacLennan; Claire Fieschi; David A Lammas; Capucine Picard; Susan E Dorman; Ozden Sanal; Jenny M MacLennan; Steven M Holland; Tom H M Ottenhoff; Jean-Laurent Casanova; Dinakantha S Kumararatne
Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.
The Journal of infectious diseases 2004;190(10):1755-7.
2004: Maytal Bivas-Benita; Marion Oudshoorn; Stefan G Romeijn; Krista E van Meijgaarden; Henk K Koerten; Hans van der Meulen; Gregory Lambert; Tom H M Ottenhoff; Simon Benita; Hans E Junginger; Gerrit Borchard
Cationic submicron emulsions for pulmonary DNA immunization.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):145-55.
2004: Milton O Moraes; Antônio Guilherme Pacheco; J J M Schonkeren; Patrícia R Vanderborght; J A C Nery; Adalberto R Santos; ELISABETE MORAES; José R Moraes; Tom H M Ottenhoff; Elizabeth P Sampaio; Tom W J Huizinga; Euzenir N Sarno
Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.
Genes and immunity 2004;5(7):592-5.
2004: Riny Janssen; Annelies van Wengen; Marieke A Hoeve; Monique M ten Dam; Mirjam van der Burg; Jacques Van Dongen; Esther van de Vosse; Maarten J D van Tol; R G M Bredius; Tom H M Ottenhoff; Corry M R Weemaes; Jaap T van Dissel; Arjan C Lankester
The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes.
The Journal of experimental medicine 2004;200(5):559-68.
2004: Zaida Araujo; J H de Waard; Carlos Fernández de Larrea; Diana López; Cecil Fandiño; A Maldonado; E Hernández; Y Ocaña; R Ortega; M Singh; Tom H M Ottenhoff; S M Arend; Jacinto Convit
Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela.
Memórias do Instituto Oswaldo Cruz 2004;99(5):517-24.
2004: Sandra M Arend; E Cerdá de Palou; Petra de Haas; Riny Janssen; Marieke A Hoeve; Els Verhard; Tom H M Ottenhoff; Dick Van Soolingen; Jaap T van Dissel
Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defect.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2004;10(8):738-48.
2004: Tom H M Ottenhoff; Michael J Bevan
Host-pathogen interactions.
Current opinion in immunology 2004;16(4):439-42.
2004: Jean-Pierre Bayley; Tom H M Ottenhoff; Cornelis L Verweij
Is there a future for TNF promoter polymorphisms?
Genes and immunity 2004;5(5):315-29.
2004: Patrícia R Vanderborght; Haroldo J Matos; Ana M Salles; Sidra E Vasconcellos; Valcemir F Silva-Filho; Tom W J Huizinga; Tom H M Ottenhoff; Elizabeth P Sampaio; Euzenir N Sarno; Adalberto R Santos; Milton O Moraes
Single nucleotide polymorphisms (SNPs) at -238 and -308 positions in the TNFalpha promoter: clinical and bacteriological evaluation in leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2004;72(2):143-8.
2004: Marta Romano; Olivier Denis; Sushila D'Souza; Xiao-Ming Wang; Tom H M Ottenhoff; Jean-Marc Brulet; Kris Huygen
Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6913-21.
2004: Maytal Bivas-Benita; Krista E van Meijgaarden; Kees L M C Franken; Hans E Junginger; Gerrit Borchard; Tom H M Ottenhoff; Annemieke Geluk
Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.
Vaccine 2004;22(13-14):1609-15.
2004: Frank A W Verreck; Tjitske de Boer; Dennis M L Langenberg; Marieke A Hoeve; Matthijs Kramer; Elena Vaisberg; Robert A Kastelein; Arend H J Kolk; Rene de Waal Malefyt; Tom H M Ottenhoff
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4560-5.
2004: Claus Aagaard; Inger Brock; Anja Olsen; Tom H M Ottenhoff; Karin Weldingh; Peter Andersen
Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex.
The Journal of infectious diseases 2004;189(5):812-9.
2004: Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Brigitte Wieles; Sandra M Arend; William R Faber; Ben Naafs; Tom H M Ottenhoff
Immunological crossreactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis.
Scandinavian journal of immunology 2004;59(1):66-70.
2003: Marieke A Hoeve; Tjitske de Boer; Dennis M L Langenberg; Ozden Sanal; Frank A W Verreck; Tom H M Ottenhoff
IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency.
European journal of immunology 2003;33(12):3393-7.
2003: Limei Meng Okkels; Inger Brock; Frank Follmann; Else Marie Agger; Sandra M Arend; Tom H M Ottenhoff; Fredrik Oftung; Ida Rosenkrands; Peter Andersen
PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family.
Infection and immunity 2003;71(11):6116-23.
2003: Maaike E Ressing; Daphne van Leeuwen; Frank A W Verreck; Raquel Gomez; Bianca Heemskerk; Mireille Toebes; Maureen M Mullen; Theodore S Jardetzky; Richard Longnecker; Marco W Schilham; Tom H M Ottenhoff; Jacques Neefjes; Schumacher Ton; Lindsey M Hutt-Fletcher; Emmanuel J H J Wiertz
Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11583-8.
2003: Ewa Koscielniak; Tjitske de Boer; Stephanie Dupuis; Ludmila Naumann; Jean-Laurent Casanova; Tom H M Ottenhoff
Disseminated Mycobacterium peregrinum infection in a child with complete interferon-gamma receptor-1 deficiency.
The Pediatric infectious disease journal 2003;22(4):378-80.
2003: Milton O Moraes; Adalberto R Santos; J J M Schonkeren; Patrícia R Vanderborght; Tom H M Ottenhoff; Maria Moraes; José R Moraes; Elizabeth P Sampaio; Euzenir N Sarno; Tom W J Huizinga
Interleukin-10 promoter haplotypes are differently distributed in the Brazilian versus the Dutch population.
Immunogenetics 2003;54(12):896-9.
2003: Esther van de Vosse; Elgin G R Lichtenauer-Kaligis; Jaap T van Dissel; Tom H M Ottenhoff
Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function.
Immunogenetics 2003;54(12):817-29.
2003: Tom H M Ottenhoff; Tjitske de Boer; Jaap T van Dissel; Frank A W Verreck
Human deficiencies in type-1 cytokine receptors reveal the essential role of type-1 cytokines in immunity to intracellular bacteria.
Advances in experimental medicine and biology 2003;531():279-94.
2003: Yanri W Subronto; Krista E van Meijgaarden; Annemieke Geluk; Sandra M Arend; Teddy Sunardi; Kees L M C Franken; Barmawi Hisyam; René R P De Vries; Tom H M Ottenhoff
Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia.
Advances in experimental medicine and biology 2003;531():249-60.
2003: Reinout van Crevel; Tom H M Ottenhoff; Jos W M van der Meer
Innate immunity to Mycobacterium tuberculosis.
Advances in experimental medicine and biology 2003;531():241-7.
2003: Elgin G R Lichtenauer-Kaligis; Tjitske de Boer; Frank A W Verreck; Sjaak van Voorden; Marieke A Hoeve; Esther van de Vosse; Fügen Ersoy; Ilhan Tezcan; Jaap T van Dissel; Ozden Sanal; Tom H M Ottenhoff
Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency.
European journal of immunology 2003;33(1):59-69.
2002: Sandra M Arend; Krista E van Meijgaarden; Kirsten de Boer; Elisabeth Cerdá de Palou; Dick Van Soolingen; Tom H M Ottenhoff; Jaap T van Dissel
Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii.
The Journal of infectious diseases 2002;186(12):1797-807.
2002: Paulo R Z Antas; Eliane B Oliveira; Alexandre S Milagres; Kees C Franken; Tom H M Ottenhoff; Paul R Klatser; Euzenir N Sarno; Elizabeth P Sampaio
Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens.
Memórias do Instituto Oswaldo Cruz 2002;97(8):1097-9.
2002: Adalberto R Santos; Philip N Suffys; Patrícia R Vanderborght; Milton O Moraes; Leila M M Vieira; Pedro H Cabello; Aleida M Bakker; Haroldo J Matos; Tom W J Huizinga; Tom H M Ottenhoff; Elizabeth P Sampaio; Euzenir N Sarno
Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy.
The Journal of infectious diseases 2002;186(11):1687-91.
2002: Fernando L L Cardoso; Paulo R Z Antas; Alexandre S Milagres; Annemieke Geluk; Kees L M C Franken; Eliane B Oliveira; Henrique C Teixeira; Susie Andries Nogueira; Euzenir N Sarno; Paul R Klatser; Tom H M Ottenhoff; Elizabeth P Sampaio
T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients.
Infection and immunity 2002;70(12):6707-14.
2002: Riny Janssen; Annelies Van Wengen; Els Verhard; Tjitske de Boer; Timo Zomerdijk; Tom H M Ottenhoff; Jaap T van Dissel
Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3900-7.
2002: Rikke Louise Vinther Skjøt; Inger Brock; Sandra M Arend; Martin E Munk; Michael Theisen; Tom H M Ottenhoff; Peter Andersen
Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family.
Infection and immunity 2002;70(10):5446-53.
2002: Tom H M Ottenhoff; Frank A W Verreck; Elgin G R Lichtenauer-Kaligis; Marieke A Hoeve; Ozden Sanal; Jaap T van Dissel
Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae.
Nature genetics 2002;32(1):97-105.
2002: Tom H M Ottenhoff
Mycobacterium leprae and demyelination.
Science (New York, N.Y.) 2002;297(5586):1475-6; author reply 1475-6.
2002: Frank A W Verreck; Tjitske de Boer; Marieke A Hoeve; Jaap T van Dissel; Ozden Sanal; Masashi Kurimoto; Tom H M Ottenhoff
Human host defense and cytokines in mycobacterial infectious diseases: interleukin-18 cannot compensate for genetic defects in the interleukin-12 system.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;35(2):210-2.
2002: Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Yanri W Subronto; Brigitte Wieles; Sandra M Arend; Elizabeth P Sampaio; Tjitske de Boer; William R Faber; Ben Naafs; Tom H M Ottenhoff
Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.
Infection and immunity 2002;70(5):2544-8.
2002: S Brahmbhatt; Rabia Hussain; Samiah Zafar; Ghaffar Dawood; Tom H M Ottenhoff; J W Drijfhout; Graham H Bothamley; S Smith; F V Lopez; Hazel M Dockrell
Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen.
Clinical and experimental immunology 2002;128(1):140-8.
2002: Reinout van Crevel; Tom H M Ottenhoff; Jos W M van der Meer
Innate immunity to Mycobacterium tuberculosis.
Clinical microbiology reviews 2002;15(2):294-309.
2002: David A Lammas; E De Heer; J David M Edgar; V Novelli; Anne Ben-Smith; R Baretto; Pam Drysdale; J Binch; Calman MacLennan; Dinakantha S Kumararatne; S Panchalingam; Tom H M Ottenhoff; Jean-Laurent Casanova; Jean-François Emile
Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway.
International journal of experimental pathology 2002;83(1):1-20.
2001: Frank A W Verreck; René R P De Vries; Tom H M Ottenhoff
Setting a course for intervening in host-pathogen interactions.
Trends in immunology 2001;22(11):588-90.
2001: Sandra M Arend; A C Engelhard; G Groot; Kirsten de Boer; Peter Andersen; Tom H M Ottenhoff; Jaap T van Dissel
Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact.
Clinical and diagnostic laboratory immunology 2001;8(6):1089-96.
2001: Sandra M Arend; Riny Janssen; J J Gosen; H Waanders; Tjitske de Boer; Tom H M Ottenhoff; Jaap T van Dissel
Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor.
The Netherlands journal of medicine 2001;59(3):140-51.
2001: S M Arend; Tom H M Ottenhoff; Peter Andersen; J T van Dissel
Uncommon presentations of tuberculosis: the potential value of a novel diagnostic assay based on the Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2001;5(7):680-6.
2001: Eric Spierings; Tjitske de Boer; Brigitte Wieles; L B Adams; Enrico Marani; Tom H M Ottenhoff
Mycobacterium leprae-specific, HLA class II-restricted killing of human Schwann cells by CD4+ Th1 cells: a novel immunopathogenic mechanism of nerve damage in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5883-8.
2001: A Macfarlane; R Mondragon-Gonzalez; F Vega-Lopez; Brigitte Wieles; J de Pena; O Rodriguez; R Suarez y de la Torre; René R P De Vries; Tom H M Ottenhoff; Hazel M Dockrell
Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.
Clinical and diagnostic laboratory immunology 2001;8(3):604-11.
2001: A Tanghe; Sushila D'Souza; Valérie Rosseels; Olivier Denis; Tom H M Ottenhoff; W Dalemans; C Wheeler; Kris Huygen
Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting.
Infection and immunity 2001;69(5):3041-7.
2001: Sjoerd H van der burg; Maaike E Ressing; Kitty M C Kwappenberg; Annemieke de Jong; K Straathof; J de Jong; Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Tom H M Ottenhoff; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa
Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.
International journal of cancer. Journal international du cancer 2001;91(5):612-8.
2001: Sandra M Arend; Dick Van Soolingen; Tom H M Ottenhoff; Jaap T van Dissel
Repeatedly negative tuberculin skin tests followed by active tuberculosis in an immunocompetent individual.
The Netherlands journal of medicine 2001;58(2):76-81.
2001: Martin E Munk; Sandra M Arend; Inger Brock; Tom H M Ottenhoff; Peter Andersen
Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis.
The Journal of infectious diseases 2001;183(1):175-6.
2000: Eric Spierings; Tjitske de Boer; Laurence Zulianello; Tom H M Ottenhoff
The role of Schwann cells, T cells and Mycobacterium leprae in the immunopathogenesis of nerve damage in leprosy.
Leprosy review 2000;71 Suppl():S121-9.
2000: Koen Vos; André M M Miltenburg; Krista E van Meijgaarden; M van den Heuvel; Diënne G Elferink; P J van Galen; R A van Hogezand; E van Vliet-Daskalopoulou; Tom H M Ottenhoff; Ferdinand C Breedveld; Mieke Boots; René R P De Vries
Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions.
Rheumatology (Oxford, England) 2000;39(12):1326-31.
2000: Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Jan Wouter Drijfhout; S D'Souza; A Necker; K Huygen; Tom H M Ottenhoff
Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6463-71.
2000: Tom H M Ottenhoff; Tjitske de Boer; Claudia Verhagen; Frank A W Verreck; Jaap T van Dissel
Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria.
Microbes and infection / Institut Pasteur 2000;2(13):1559-66.
2000: Claudia Verhagen; Hermelijn H Smits; Frank A W Verreck; Eddy A Wierenga; M Kurimoto; David A Lammas; Dinakantha S Kumararatne; Ozden Sanal; F P Kroon; F Sinigaglia; Tom H M Ottenhoff
Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells.
The Journal of experimental medicine 2000;192(4):517-28.
2000: Eric Spierings; Tjitske de Boer; Laurence Zulianello; Tom H M Ottenhoff
Novel mechanisms in the immunopathogenesis of leprosy nerve damage: the role of Schwann cells, T cells and Mycobacterium leprae.
Immunology and cell biology 2000;78(4):349-55.
2000: Sandra M Arend; Annemieke Geluk; Krista E van Meijgaarden; Jaap T van Dissel; M Theisen; Peter Andersen; Tom H M Ottenhoff
Antigenic equivalence of human T-cell responses to Mycobacterium tuberculosis-specific RD1-encoded protein antigens ESAT-6 and culture filtrate protein 10 and to mixtures of synthetic peptides.
Infection and immunity 2000;68(6):3314-21.
2000: Sandra M Arend; Peter Andersen; Krista E van Meijgaarden; R L Skjot; Yanri W Subronto; Jaap T van Dissel; Tom H M Ottenhoff
Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10.
The Journal of infectious diseases 2000;181(5):1850-4.
2000: Marieke van Ham; Marcel van Lith; B Lillemeier; EP Tjin; U Grüneberg; Dinah Rahman; L Pastoors; Krista E van Meijgaarden; C Roucard; J Trowsdale; Tom H M Ottenhoff; Darryl Pappin; Jacques Neefjes
Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO.
The Journal of experimental medicine 2000;191(7):1127-36.
2000: Kees L M C Franken; HS Hiemstra; Krista E van Meijgaarden; Yanri W Subronto; Jan den Hartigh; Tom H M Ottenhoff; Jan Wouter Drijfhout
Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent.
Protein expression and purification 2000;18(1):95-9.
1999: HS Hiemstra; Peter van Veelen; Annemieke Geluk; Nanette C Schloot; René R P De Vries; Tom H M Ottenhoff; Bart O Roep; Jan Wouter Drijfhout
Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes.
Vaccine 1999;18(3-4):204-8.
1999: Eric Spierings; M de Vlieger; A Brand; P R Klatser; Tom H M Ottenhoff
Antibodies to sulfatide in leprosy and leprosy reactions.
The American journal of tropical medicine and hygiene 1999;61(3):495-9.
1999: JE Thole; Anneke A M Janson; Y Cornelisse; G M Th Schreuder; Brigitte Wieles; Ben Naafs; René R P De Vries; Tom H M Ottenhoff
HLA-class II-associated control of antigen recognition by T cells in leprosy: a prominent role for the 30/31-kDa antigens.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6912-8.
1999: Sjoerd H van der burg; Kitty M C Kwappenberg; Annemieke Geluk; M van der Kruk; Oscar Pontesilli; Egbert Hovenkamp; Kees L M C Franken; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff; Cornelis J M Melief; Rienk Offringa
Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):152-60.
1998: Tom H M Ottenhoff; Dinakantha S Kumararatne; J L Casanova
Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria.
Immunology today 1998;19(11):491-4.
1998: HS Hiemstra; Peter van Veelen; Nanette C Schloot; Annemieke Geluk; Krista E van Meijgaarden; Sabine Willemen; Jack Leunissen; Willemien Benckhuijsen; R Amons; René R P De Vries; Bart O Roep; Tom H M Ottenhoff; Jan Wouter Drijfhout
Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4078-82.
1998: Annemieke Geluk; Krista E van Meijgaarden; Nanette C Schloot; Jan Wouter Drijfhout; Tom H M Ottenhoff; Bart O Roep
HLA-DR binding analysis of peptides from islet antigens in IDDM.
Diabetes 1998;47(10):1594-601.
1998: M C Agnes; A Tan; R Jordens; Annemieke Geluk; B O Roep; Tom H M Ottenhoff; Jan Wouter Drijfhout; Frits Koning
Strongly increased efficiency of altered peptide ligands by mannosylation.
International immunology 1998;10(9):1299-304.
1998: Annemieke Geluk; V Taneja; Krista E van Meijgaarden; Eric Zanelli; C Abou-Zeid; JE Thole; René R P De Vries; Chella S David; Tom H M Ottenhoff
Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10797-802.
1998: Annemieke Geluk; Krista E van Meijgaarden; Bart O Roep; Tom H M Ottenhoff
Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes.
Journal of autoimmunity 1998;11(4):353-61.
1998: R de Jong; F Altare; I A Haagen; Diënne G Elferink; T Boer; P J van Breda Vriesman; PJ Kabel; Jos M Th Draaisma; Jaap T van Dissel; F P Kroon; J L Casanova; Tom H M Ottenhoff
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.
Science (New York, N.Y.) 1998;280(5368):1435-8.
1998: ML De Bruijn; Danita Schuurhuis; Michel P M Vierboom; H Vermeulen; K A de Cock; Marlies E Ooms; Maaike E Ressing; Mireille Toebes; Kees L M C Franken; Jan Wouter Drijfhout; Tom H M Ottenhoff; Rienk Offringa; Cornelis J M Melief
Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells.
Cancer research 1998;58(4):724-31.
1998: Annemieke Geluk; V Taneja; Krista E van Meijgaarden; René R P De Vries; Chella S David; Tom H M Ottenhoff
HLA-DR/DQ transgenic, class II deficient mice as a novel model to select for HSP T cell epitopes with immunotherapeutic or preventative vaccine potential.
Biotherapy (Dordrecht, Netherlands) 1998;10(3):191-6.
1997: SM van Ham; EP Tjin; B F Lillemeier; U Grüneberg; Krista E van Meijgaarden; L Pastoors; Desiree Verwoerd; A Tulp; Benito Canas; Dinah Rahman; Tom H M Ottenhoff; Darryl Pappin; J Trowsdale; Jacques Neefjes
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading.
Current biology : CB 1997;7(12):950-7.
1997: MC Tan; A Mieke Mommaas; Jan Wouter Drijfhout; R Jordens; Jos J M Onderwater; Desiree Verwoerd; Aat A Mulder; A N van der Heiden; D Scheidegger; Lauran Oomen; Tom H M Ottenhoff; A Tulp; Jacques Neefjes; Frits Koning
Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells.
European journal of immunology 1997;27(9):2426-35.
1997: Tom H M Ottenhoff; Eric Spierings; P H Nibbering; R de Jong
Modulation of protective and pathological immunity in mycobacterial infections.
International archives of allergy and immunology 1997;113(4):400-8.
1997: R de Jong; Anneke A M Janson; William R Faber; Ben Naafs; Tom H M Ottenhoff
IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):786-93.
1997: T L Tan; Annemieke Geluk; Mireille Toebes; Tom H M Ottenhoff; Jan Wouter Drijfhout
A novel, highly efficient peptide-HLA class I binding assay using unfolded heavy chain molecules: identification of HIV-1 derived peptides that bind to HLA-A*0201 and HLA-A*0301.
Journal of immunological methods 1997;205(2):201-9.
1997: Brigitte Wieles; Tom H M Ottenhoff; T M Steenwijk; Kees L M C Franken; René R P De Vries; J A Langermans
Increased intracellular survival of Mycobacterium smegmatis containing the Mycobacterium leprae thioredoxin-thioredoxin reductase gene.
Infection and immunity 1997;65(7):2537-41.
1997: Annemieke Geluk; Krista E van Meijgaarden; Tom H M Ottenhoff
Flexibility in T-cell receptor ligand repertoires depends on MHC and T-cell receptor clonotype.
Immunology 1997;90(3):370-5.
1997: Tom H M Ottenhoff; Annemieke Geluk; Mireille Toebes; Willemien Benckhuijsen; Krista E van Meijgaarden; Jan Wouter Drijfhout
A sensitive fluorometric assay for quantitatively measuring specific peptide binding to HLA class I and class II molecules.
Journal of immunological methods 1997;200(1-2):89-97.
1997: MC Tan; A Mieke Mommaas; Jan Wouter Drijfhout; R Jordens; Jos J M Onderwater; Desiree Verwoerd; Aat A Mulder; A N van der Heiden; Tom H M Ottenhoff; M Cella; A Tulp; Jacques Neefjes; Frits Koning
Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells.
Advances in experimental medicine and biology 1997;417():171-4.
1996: R de Jong; A C Bezemer; Timo Zomerdijk; T van de Pouw-Kraan; Tom H M Ottenhoff; Peter H Nibbering
Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate.
European journal of immunology 1996;26(9):2067-74.
1995: J E Thole; Brigitte Wieles; Josephine E Clark-Curtiss; Tom H M Ottenhoff; T F Rinke de Wit
Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview.
Molecular microbiology 1995;18(5):791-800.
1995: Brigitte Wieles; S Nagai; Harald Gotten Wiker; M Harboe; Tom H M Ottenhoff
Identification and functional characterization of thioredoxin of Mycobacterium tuberculosis.
Infection and immunity 1995;63(12):4946-8.
1995: Brigitte Wieles; E Spierings; J van Noort; Ben Naafs; R Offringa; Tom H M Ottenhoff
Molecular characterization and T-cell-stimulatory capacity of Mycobacterium leprae antigen T5.
Infection and immunity 1995;63(12):4682-5.
1995: Brigitte Wieles; J van Noort; Jan Wouter Drijfhout; R Offringa; A Holmgren; Tom H M Ottenhoff
Purification and functional analysis of the Mycobacterium leprae thioredoxin/thioredoxin reductase hybrid protein.
The Journal of biological chemistry 1995;270(43):25604-6.
1995: Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff
Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.
Molecular immunology 1995;32(13):975-81.
1995: Tom H M Ottenhoff; T Mutis
Role of cytotoxic cells in the protective immunity against and immunopathology of intracellular infections.
European journal of clinical investigation 1995;25(6):371-7.
1995: Brigitte Wieles; D van Soolingen; A Holmgren; R Offringa; Tom H M Ottenhoff; J Thole
Unique gene organization of thioredoxin and thioredoxin reductase in Mycobacterium leprae.
Molecular microbiology 1995;16(5):921-9.
1994: Annemieke Geluk; X T Fu; Krista E van Meijgaarden; Y Y Jansen; René R P De Vries; R W Karr; Tom H M Ottenhoff
T cell receptor and peptide-contacting residues in the HLA-DR17(3) beta 1 chain.
European journal of immunology 1994;24(12):3241-4.
1994: T Mutis; Y E Cornelisse; G Datema; Peter J van den Elsen; Tom H M Ottenhoff; René R P De Vries
Definition of a human suppressor T-cell epitope.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9456-60.
1994: Annemieke Geluk; Krista E van Meijgaarden; Scott Southwood; Carla Oseroff; Jan Wouter Drijfhout; René R P De Vries; Tom H M Ottenhoff; Alessandro Sette
HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5742-8.
1993: B G Elferink; Annemieke Geluk; Nel Otting; Bas Slierendregt; Krista E van Meijgaarden; René R P De Vries; Tom H M Ottenhoff; Ronald E Bontrop
The biologic importance of conserved major histocompatibility complex class II motifs in primates.
Human immunology 1993;38(3):201-5.
1993: T Mutis; Y E Cornelisse; Tom H M Ottenhoff
Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levels.
European journal of immunology 1993;23(9):2189-95.
1993: T Mutis; E M Kraakman; Y E Cornelisse; J B Haanen; H Spits; René R P De Vries; Tom H M Ottenhoff
Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4641-51.
1993: Annemieke Geluk; Diënne G Elferink; Bas Slierendregt; Krista E van Meijgaarden; René R P De Vries; Tom H M Ottenhoff; Ronald E Bontrop
Evolutionary conservation of major histocompatibility complex-DR/peptide/T cell interactions in primates.
The Journal of experimental medicine 1993;177(4):979-87.
1993: T Mutis; M De Bueger; A Bakker; Tom H M Ottenhoff
HLA class II+ human keratinocytes present Mycobacterium leprae antigens to CD4+ Th1-like cells.
Scandinavian journal of immunology 1993;37(1):43-51.
1992: Annemieke Geluk; Krista E van Meijgaarden; Anneke A M Janson; Jan Wouter Drijfhout; R H Meloen; René R P De Vries; Tom H M Ottenhoff
Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2864-71.
1992: J E Thole; R Schöningh; Anneke A M Janson; T Garbe; Y E Cornelisse; Josephine E Clark-Curtiss; Arend H J Kolk; Tom H M Ottenhoff; René R P De Vries; C Abou-Zeid
Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae.
Molecular microbiology 1992;6(2):153-63.
1992: Annemieke Geluk; W Bloemhoff; René R P De Vries; Tom H M Ottenhoff
Binding of a major T cell epitope of mycobacteria to a specific pocket within HLA-DRw17(DR3) molecules.
European journal of immunology 1992;22(1):107-13.
1991: Anneke A M Janson; Paul R Klatser; R van der Zee; Y E Cornelisse; René R P De Vries; J E Thole; Tom H M Ottenhoff
A systematic molecular analysis of the T cell-stimulating antigens from Mycobacterium leprae with T cell clones of leprosy patients. Identification of a novel M. leprae HSP 70 fragment by M. leprae-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(10):3530-7.
1991: S Sela; J E Thole; Tom H M Ottenhoff; Josephine E Clark-Curtiss
Identification of Mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients.
Infection and immunity 1991;59(11):4117-24.
1991: J B Haanen; R de Waal Malefijt; P C Res; E M Kraakman; Tom H M Ottenhoff; René R P De Vries; H Spits
Selection of a human T helper type 1-like T cell subset by mycobacteria.
The Journal of experimental medicine 1991;174(3):583-92.
1991: Tom H M Ottenhoff; J B Haanen; Annemieke Geluk; T Mutis; B K Ab; J E Thole; W C van Schooten; Peter J van den Elsen; René R P De Vries
Regulation of mycobacterial heat-shock protein-reactive T cells by HLA class II molecules: lessons from leprosy.
Immunological reviews 1991;121():171-91.
1990: J B Haanen; Tom H M Ottenhoff; R F Lai A Fat; H Soebono; H Spits; René R P De Vries
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3898-904.
1990: Paul J Converse; Tom H M Ottenhoff; S Work Teklemariam; G E Hancock; M Dietz; M Becx-Bleumink; A Wondimu; Rolf Kiessling; Z A Cohn; Gilla Kaplan
Intradermal recombinant interleukin 2 enhances peripheral blood T-cell responses to mitogen and antigens in patients with lepromatous leprosy.
Scandinavian journal of immunology 1990;32(2):83-91.
1990: S G Li; Tom H M Ottenhoff; P Van den Elsen; Frits Koning; L Zhang; T Mak; René R P De Vries
Human suppressor T cell clones lack CD28.
European journal of immunology 1990;20(6):1281-8.
1990: Tom H M Ottenhoff; T Mutis
Specific killing of cytotoxic T cells and antigen-presenting cells by CD4+ cytotoxic T cell clones. A novel potentially immunoregulatory T-T cell interaction in man.
The Journal of experimental medicine 1990;171(6):2011-24.
1990: Tom H M Ottenhoff; A Wondimu; N N Reddy
A comparative study on the effects of rIL-4, rIL-2, rIFN-gamma, and rTNF-alpha on specific T-cell non-responsiveness to mycobacterial antigens in lepromatous leprosy patients in vitro.
Scandinavian journal of immunology 1990;31(5):553-65.
1990: B K Ab; Rolf Kiessling; J D Van Embden; J E Thole; D S Kumararatne; P Pisa; A Wondimu; Tom H M Ottenhoff
Induction of antigen-specific CD4+ HLA-DR-restricted cytotoxic T lymphocytes as well as nonspecific nonrestricted killer cells by the recombinant mycobacterial 65-kDa heat-shock protein.
European journal of immunology 1990;20(2):369-77.
1990: Tom H M Ottenhoff; René R P De Vries
Antigen reactivity and autoreactivity: two sides of the cellular immune response induced by mycobacteria.
Current topics in microbiology and immunology 1990;155():111-21.
1989: Tom H M Ottenhoff; Paul J Converse; N Gebre; A Wondimu; J P Ehrenberg; Rolf Kiessling
T cell responses to fractionated Mycobacterium leprae antigens in leprosy. The lepromatous nonresponder defect can be overcome in vitro by stimulation with fractionated M. leprae components.
European journal of immunology 1989;19(4):707-13.
1989: Gilla Kaplan; Rolf Kiessling; S Teklemariam; G Hancock; G Sheftel; C K Job; Paul J Converse; Tom H M Ottenhoff; M Becx-Bleumink; M Dietz
The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2.
The Journal of experimental medicine 1989;169(3):893-907.
1988: Tom H M Ottenhoff; B K Ab; J D Van Embden; J E Thole; Rolf Kiessling
The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.
The Journal of experimental medicine 1988;168(5):1947-52.
1988: W C Van Schooten; Tom H M Ottenhoff; Paul R Klatser; J Thole; René R P De Vries; Arend H J Kolk
T cell epitopes on the 36K and 65K Mycobacterium leprae antigens defined by human T cell clones.
European journal of immunology 1988;18(6):849-54.
1988: Paul J Converse; Tom H M Ottenhoff; N Gebre; J P Ehrenberg; Rolf Kiessling
Cellular, humoral, and gamma interferon responses to Mycobacterium leprae and BCG antigens in healthy individuals exposed to leprosy.
Scandinavian journal of immunology 1988;27(5):515-25.
1988: René R P De Vries; Tom H M Ottenhoff; W C van Schooten
Human leukocyte antigens (HLA) and mycobacterial disease.
Springer seminars in immunopathology 1988;10(4):305-18.
1987: Tom H M Ottenhoff; M Mengistu; G Tadesse; R R De Vries; Paul J Converse
HLA-DR and DQ antigens in insulin-dependent diabetics in Ethiopia.
Tissue antigens 1987;30(5):193-7.
1987: Tom H M Ottenhoff; René R P De Vries
HLA class II immune response and suppression genes in leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1987;55(3):521-34.
1987: Tom H M Ottenhoff; Paul J Converse; G Bjune; R R de Vries
HLA antigens and neural reversal reactions in Ethiopian borderline tuberculoid leprosy patients.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1987;55(2):261-6.
1986: Tom H M Ottenhoff; S Neuteboom; Diënne G Elferink; René R P De Vries
Molecular localization and polymorphism of HLA class II restriction determinants defined by Mycobacterium leprae-reactive helper T cell clones from leprosy patients.
The Journal of experimental medicine 1986;164(6):1923-39.
1986: Tom H M Ottenhoff; Diënne G Elferink; Paul R Klatser; René R P De Vries
Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells.
Nature 1986;322(6078):462-4.
1986: Tom H M Ottenhoff; Paul R Klatser; J Ivanyi; Diënne G Elferink; M Y de Wit; René R P De Vries
Mycobacterium leprae-specific protein antigens defined by cloned human helper T cells.
Nature 1986;319(6048):66-8.
1986: J B Haanen; Tom H M Ottenhoff; A Voordouw; B G Elferink; P R Klatser; H Spits; René R P De Vries
HLA class-II-restricted Mycobacterium leprae-reactive T-cell clones from leprosy patients established with a minimal requirement for autologous mononuclear cells.
Scandinavian journal of immunology 1986;23(1):101-8.
1985: B G Elferink; Tom H M Ottenhoff; René R P De Vries
Epstein-Barr virus-transformed B cell lines present M. leprae antigens to T cells.
Scandinavian journal of immunology 1985;22(5):585-9.
1985: Tom H M Ottenhoff; Diënne G Elferink; A Termijtelen; Frits Koning; René R P De Vries
HLA class II restriction repertoire of antigen-specific T cells. II. Evidence for a new restriction determinant associated with DRw52 and LB-Q1.
Human immunology 1985;13(2):117-23.
1985: Tom H M Ottenhoff; Diënne G Elferink; J Hermans; René R P De Vries
HLA class II restriction repertoire of antigen-specific T cells. I. The main restriction determinants for antigen presentation are associated with HLA-D/DR and not with DP and DQ.
Human immunology 1985;13(2):105-16.
1984: Tom H M Ottenhoff; Diënne G Elferink; René R P De Vries
Unresponsiveness to Mycobacterium leprae in lepromatous leprosy in vitro: reversible or not?
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1984;52(3):419-24.