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Ivan Otterness

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Ivan G Otterness; Marie-Pierre Hellio Le Graverand; Felix Eckstein
Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions.
Ivan G Otterness; Kenneth D Brandt; Marie-Pierre Hellio Le Graverand; Steven A Mazzuca
Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing.
Ivan G Otterness; F Eckstein
Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight.

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All Publications

2008: Ivan G Otterness; Marie-Pierre Hellio Le Graverand; Felix Eckstein
Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(1):34-40.
2007: Ivan G Otterness; Kenneth D Brandt; Marie-Pierre Hellio Le Graverand; Steven A Mazzuca
Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing.
Arthritis and rheumatism 2007;56(11):3644-9.
2007: Ivan G Otterness; F Eckstein
Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(6):666-72.
2005: Mark C Noe; Vijayalakshmi Natarajan; Sheri L Snow; Lilli A Wolf-Gouveia; Peter G Mitchell; Lori L Lopresti-Morrow; Lisa M Reeves; Sue A Yocum; Ivan G Otterness; Marcia A Bliven; Thomas J Carty; John T Barberia; Francis J Sweeney; Jennifer L Liras; Marcie Vaughn
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.
Bioorganic & medicinal chemistry letters 2005;15(14):3385-8.
2004: Lawrence A Reiter; Ralph P Robinson; Kim F McClure; Christopher S Jones; Matthew R Reese; Peter G Mitchell; Ivan G Otterness; Marcia L Bliven; Jennifer L Liras; Santo R Cortina; Kathleen M Donahue; James D Eskra; Richard J Griffiths; Mary E Lame; Arturo Lopez-Anaya; Gary J Martinelli; Shunda M McGahee; Sue A Yocum; Lori L Lopresti-Morrow; Lisa M Tobiassen; Marcie L Vaughn-Bowser
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Bioorganic & medicinal chemistry letters 2004;14(13):3389-95.
2003: Ivan G Otterness; AC Swindell
Criteria for selection and application of molecular markers for clinical studies of osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(3):153-8.
2002: Clare L Curtis; Sarah G Rees; Christopher B Little; Carl R Flannery; Clare E Hughes; Chris Wilson; Colin M Dent; Ivan G Otterness; John L Harwood; Bruce Caterson
Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Arthritis and rheumatism 2002;46(6):1544-53.
2002: Marie-Pierre Hellio Le Graverand; Jonna Eggerer; Eric Vignon; Ivan G Otterness; Leona Barclay; David A Hart
Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(3):535-44.
2002: Christopher B Little; Clare E Hughes; Clare L Curtis; Michael J Janusz; Richard Bohne; Sherry Wang-Weigand; Yetunde O Taiwo; Peter G Mitchell; Ivan G Otterness; Carl R Flannery; Bruce Caterson
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(3):271-88.
2002: Amy G Clark; Amy L Rohrbaugh; Ivan G Otterness; Virginia B Kraus
The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(2):175-84.
2001: Ivan G Otterness; E Weiner; AC Swindell; R O Zimmerer; M Ionescu; A R Poole
An analysis of 14 molecular markers for monitoring osteoarthritis. Relationship of the markers to clinical end-points.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(3):224-31.
2001: Marie-Pierre Hellio Le Graverand; Eric Vignon; Ivan G Otterness; David A Hart
Early changes in lapine menisci during osteoarthritis development: Part II: molecular alterations.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):65-72.
2001: Marie-Pierre Hellio Le Graverand; Eric Vignon; Ivan G Otterness; David A Hart
Early changes in lapine menisci during osteoarthritis development: Part I: cellular and matrix alterations.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(1):56-64.
2001: J T Downs; C L Lane; Nestor B Nestor; T J McLellan; M A Kelly; George A Karam; P S Mezes; J P Pelletier; Ivan G Otterness
Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA.
Journal of immunological methods 2001;247(1-2):25-34.
2000: Marie-Pierre Hellio Le Graverand; Jonna Eggerer; Paul Sciore; Carol Reno; Eric Vignon; Ivan G Otterness; David A Hart
Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(5):431-41.
2000: Ivan G Otterness; Marcia L Bliven; James D Eskra; Johan teKoppele; Hans A Stukenbrok; Anthony J Milici
Cartilage damage after intraarticular exposure to collagenase 3.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(5):366-73.
2000: Ivan G Otterness; AC Swindell; R O Zimmerer; A R Poole; M Ionescu; E Weiner
An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):180-5.
1999: Ivan G Otterness; J T Downs; C Lane; Marcia L Bliven; Hans A Stukenbrok; DN Scampoli; Anthony J Milici; P S Mézes
Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(4):331-41.
1999: John E Burkhardt; James D Eskra; F A Clemo; Ivan G Otterness
Effects of nalidixic acid on hamster knee cartilage morphology and synovial fluid composition.
Toxicologic pathology 1999;27(4):421-6.
1999: Ivan G Otterness; M Chang; John E Burkhardt; F J Sweeney; Anthony J Milici
Histology and tissue chemistry of tidemark separation in hamsters.
Veterinary pathology 1999;36(2):138-45.
1998: Ivan G Otterness; James D Eskra; Marcia L Bliven; A K Shay; J P Pelletier; Anthony J Milici
Exercise protects against articular cartilage degeneration in the hamster.
Arthritis and rheumatism 1998;41(11):2068-76.
1998: Janet L Huebner; Ivan G Otterness; E M Freund; Bruce Caterson; Virginia B Kraus
Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Arthritis and rheumatism 1998;41(5):877-90.
1997: Marcia L Bliven; James D Eskra; Ivan G Otterness
Limitation of activity in an acute model of arthritis: effect of drug treatment.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(12):491-5.
1996: Ivan G Otterness; Gaston O Daumy; M G Gollaher; J T Downs; T J Zuzel; Marcia L Bliven; J M Merenda
Determining selectivity of drugs by quantitative two-dimensional gel analysis. A study of tenidap, piroxicam, and dexamethasone.
Biochemical pharmacology 1996;52(6):917-25.
1996: Marcia L Bliven; Ivan G Otterness
Facing the future: drug discovery reconsidered.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(8):365-9.
1996: P F Moore; D L Larson; Ivan G Otterness; A Weissman; S B Kadin; F J Sweeney; James D Eskra; Atsushi Nagahisa; M Sakakibara; T J Carty
Tenidap, a structurally novel drug for the treatment of arthritis: antiinflammatory and analgesic properties.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1996;45(2):54-61.
1995: Richard J Griffiths; E J Stam; J T Downs; Ivan G Otterness
ATP induces the release of IL-1 from LPS-primed cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2821-8.
1995: A K Shay; Marcia L Bliven; D N Scampoli; Ivan G Otterness; Anthony J Milici
Effects of exercise on synovium and cartilage from normal and inflamed knees.
Rheumatology international 1995;14(5):183-9.
1994: Ivan G Otterness; Marcia L Bliven; Anthony J Milici; A R Poole
Comparison of mobility changes with histological and biochemical changes during lipopolysaccharide-induced arthritis in the hamster.
The American journal of pathology 1994;144(5):1098-108.
1993: Ivan G Otterness; Anthony J Milici; Marcia L Bliven
Some factors affecting inhibition and restoration of mobility after induction of an acute arthritis in the hamster.
Agents and actions 1993;40(3-4):224-7.
1993: Ivan G Otterness; D C Hanson; Marcia L Bliven
Possible role of IL-1 in arthritis: effects of prostaglandins in the regulation of IL-1 synthesis and actions.
Agents and actions. Supplements 1993;39():109-20.
1991: Ivan G Otterness; H W Golden; P A Seymour; James D Eskra; G O Daumy
Role of prostaglandins in the behavioral changes induced by murine interleukin 1 alpha in the rat.
Cytokine 1991;3(4):333-8.
1991: Ivan G Otterness; Marcia L Bliven; J T Downs; E J Natoli; D C Hanson
Inhibition of interleukin 1 synthesis by tenidap: a new drug for arthritis.
Cytokine 1991;3(4):277-83.
1991: G O Daumy; C L Wilder; J M Merenda; A S McColl; Kieran F Geoghegan; Ivan G Otterness
Reduction of biological activity of murine recombinant interleukin-1 beta by selective deamidation at asparagine-149.
FEBS letters 1991;278(1):98-102.
1990: S K Rouan; Ivan G Otterness; A C Cunningham; H E Holden; CT Rhodes
Reversal of colchicine-induced mitotic arrest in Chinese hamster cells with a colchicine-specific monoclonal antibody.
The American journal of pathology 1990;137(4):779-87.
1990: D Girard; R M Aloisi; Marcia L Bliven; A C Cunningham; Ivan G Otterness
Cyclophosphamide and 15(S)-15 methyl PGE1 correct the T/B lymphocyte ratios of NZB/NZW mice.
Agents and actions 1990;29(3-4):333-41.
1989: Ivan G Otterness; H W Golden; W H Brissette; P A Seymour; G O Daumy
Effects of continuously administered murine interleukin-1 alpha: tolerance development and granuloma formation.
Infection and immunity 1989;57(9):2742-50.
1989: S K Edmond Rouan; Ivan G Otterness; A C Cunningham; CT Rhodes
Specific, high affinity colchicine binding monoclonal antibodies: development and characterization of the antibodies.
Hybridoma 1989;8(4):435-48.
1989: R L Archer; A C Cunningham; Peter F Moore; J A Potter; Marcia L Bliven; Ivan G Otterness
Effects of dazmegrel, piroxicam and cyclophosphamide on the NZB/W model of SLE.
Agents and actions 1989;27(3-4):369-74.
1988: Marcia L Bliven; A C Cunningham; Ivan G Otterness
A pharmacologic study of the relationship between lymphocyte function and surface antigen expression.
Agents and actions 1988;25(1-2):86-93.
1988: Ivan G Otterness; Marcia L Bliven; James D Eskra; M Reinke; D C Hanson
The pharmacologic regulation of interleukin-1 production: the role of prostaglandins.
Cellular immunology 1988;114(2):385-97.
1988: Ivan G Otterness; P A Seymour; H W Golden; J A Reynolds; G O Daumy
The effects of continuous administration of murine interleukin-1 alpha in the rat.
Physiology & behavior 1988;43(6):797-804.
1987: H W Golden; D A Iacuzio; Ivan G Otterness
Inhibition of C5a-induced basophil degranulation by disodium cromoglycate.
Agents and actions 1987;21(3-4):371-4.
1986: Marcia L Bliven; Paul H Wooley; M B Pepys; Ivan G Otterness
Murine type II collagen arthritis. Association of an acute-phase response with clinical course.
Arthritis and rheumatism 1986;29(9):1131-8.
1986: H W Golden; G L Crean; D A Iacuzio; Ivan G Otterness
Effect of disodium cromoglycate on cutaneous basophil anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(5):1495-503.