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Gottfried Otting

Research Profile

Phenomena

Magnetic Resonance Spectroscopy

Procedures

Nuclear Magnetic Resonance, Biomolecular

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Living Beings

Escherichia coli

Physiology

Protein Folding

Co-author Network

Publications

TOP 3
Isaac N Arthur; Samuel A Fraser; James E Hennessy; Stéphanie Lesturgez; Mantas Liutkus; John G Oakeshott; Gottfried Otting; Dharshana Padmakshan; Dannon J Stigers; Christopher J Easton
In Situ Deprotection and Incorporation of Unnatural Amino Acids during Cell-Free Protein Synthesis.
Choy Theng Loh; Gottfried Otting; Kiyoshi Ozawa; Kellie L Tuck; Nicholas Barlow; Thomas Huber; Bim Graham
Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins.
Ilia Kaminker; Nurit Manukovsky; Gottfried Otting; Igor Tkach; Hiromasa Yagi; Marina Bennati; Thomas Huber; Daniella Goldfarb
W-band orientation selective DEER measurements on a Gd3+/nitroxide mixed-labeled protein dimer with a dual mode cavity.

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All Publications

2013: Isaac N Arthur; Samuel A Fraser; James E Hennessy; Stéphanie Lesturgez; Mantas Liutkus; John G Oakeshott; Gottfried Otting; Dharshana Padmakshan; Dannon J Stigers; Christopher J Easton
In Situ Deprotection and Incorporation of Unnatural Amino Acids during Cell-Free Protein Synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(21):6824-30.
2013: Choy Theng Loh; Gottfried Otting; Kiyoshi Ozawa; Kellie L Tuck; Nicholas Barlow; Thomas Huber; Bim Graham
Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins.
Bioconjugate chemistry 2013;24(2):260-8.
2013: Ilia Kaminker; Nurit Manukovsky; Gottfried Otting; Igor Tkach; Hiromasa Yagi; Marina Bennati; Thomas Huber; Daniella Goldfarb
W-band orientation selective DEER measurements on a Gd3+/nitroxide mixed-labeled protein dimer with a dual mode cavity.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2013;227():66-71.
2013: Hiromasa Yagi; Ansis Maleckis; Gottfried Otting
A systematic study of labelling an α-helix in a protein with a lanthanide using IDA-SH or NTA-SH tags.
Journal of biomolecular NMR 2013;55(2):157-66.
2013: Karin V Loscha; Gottfried Otting
Biosynthetically directed ²H labelling for stereospecific resonance assignments of glycine methylene groups.
Journal of biomolecular NMR 2013;55(1):97-104.
2012: Alessandro Marchetti; Gottfried Otting; Ah Young Park; Nicholas E Dixon; Lyndon Emsley; Michele Felletti; Stefan Jehle; Michael J Knight; Anne Lesage; Yao Wang; Zhi-Qiang Xu; Guido Pintacuda
Backbone assignment of fully protonated solid proteins by 1H detection and ultrafast magic-angle-spinning NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2012;51(43):10756-9.
2012: Ilia Kaminker; Gottfried Otting; Hiromasa Yagi; Akiva Feintuch; Thomas Huber; Daniella Goldfarb
Spectroscopic selection of distance measurements in a protein dimer with mixed nitroxide and Gd3+ spin labels.
Physical chemistry chemical physics : PCCP 2012;14(13):4355-8.
2012: Christophe Schmitz; Robert Vernon; David Baker; Gottfried Otting; Thomas Huber
Protein structure determination from pseudocontact shifts using ROSETTA.
Journal of molecular biology 2012;416(5):668-77.
2012: Karin V Loscha; Anthony J Herlt; Thomas Huber; Kiyoshi Ozawa; Ruhu Qi; Gottfried Otting
Multiple-site labeling of proteins with unnatural amino acids.
Angewandte Chemie (International ed. in English) 2012;51(9):2243-6.
2012: Kiyoshi Ozawa; Nicholas E Dixon; Kekini V Kuppan; Choy Theng Loh; Karin V Loscha; Gottfried Otting
High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites.
Biochemical and biophysical research communications 2012;418(4):652-6.
2011: Dmitry Shishmarev; Gottfried Otting
Radiation damping on cryoprobes.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2011;213(1):76-81.
2011: Laura de la Cruz; Bim Graham; Thomas Huber; Thi Hoang Duong Nguyen; Kiyoshi Ozawa; James Shin; Gottfried Otting
Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts.
Journal of the American Chemical Society 2011;133(47):19205-15.
2011: Bim Graham; Thomas Huber; Xinying Jia; Choy Theng Loh; Guido Pintacuda; James Shin; James David Swarbrick; Phuc Ung; Hiromasa Yagi; Nicholas Barlow; Sandeep Chhabra; Gottfried Otting
DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra.
Bioconjugate chemistry 2011;22(10):2118-25.
2011: Hiromasa Yagi; Debamalya Banerjee; Daniella Goldfarb; Bim Graham; Thomas Huber; Gottfried Otting
Gadolinium tagging for high-precision measurements of 6 nm distances in protein assemblies by EPR.
Journal of the American Chemical Society 2011;133(27):10418-21.
2011: Xinying Jia; Ansis Maleckis; Thomas Huber; Gottfried Otting
4,4'-dithiobisdipicolinic acid: a small and convenient lanthanide binding tag for protein NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(24):6830-6.
2011: Xun-Cheng Su; Choy-Theng Loh; Ruhu Qi; Gottfried Otting
Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O.
Journal of biomolecular NMR 2011;50(1):35-42.
2011: Isaac N Ugwumba; Zhi-Qiang Xu; Sue Brown; Chris Coppin; Nicholas E Dixon; Fernanda Ely; Jee-Loon Foo; Anthony J Herlt; Lewis N Mander; John G Oakeshott; David L Ollis; Gottfried Otting; Kiyoshi Ozawa; Gerhard Schenk; Matthew C Taylor; Colin J Jackson
Improving a natural enzyme activity through incorporation of unnatural amino acids.
Journal of the American Chemical Society 2011;133(2):326-33.
2011: Thi Hoang Duong Nguyen; Kiyoshi Ozawa; Mitchell Stanton-Cook; Russell Barrow; Thomas Huber; Gottfried Otting
Generation of pseudocontact shifts in protein NMR spectra with a genetically encoded cobalt(II)-binding amino acid.
Angewandte Chemie (International ed. in English) 2011;50(3):692-4.
2010: Alexey Potapov; Hiromasa Yagi; Thomas Huber; Slobodan Jergic; Nicholas E Dixon; Gottfried Otting; Daniella Goldfarb
Nanometer-scale distance measurements in proteins using Gd3+ spin labeling.
Journal of the American Chemical Society 2010;132(26):9040-8.
2010: Hiromasa Yagi; Karin V Loscha; Xun-Cheng Su; Mitchell Stanton-Cook; Thomas Huber; Gottfried Otting
Tunable paramagnetic relaxation enhancements by [Gd(DPA)(3)] (3-) for protein structure analysis.
Journal of biomolecular NMR 2010;47(2):143-53.
2010: Bradley Man; Xun-Cheng Su; Haobo Liang; Shane Simonsen; Thomas Huber; Barbara A Messerle; Gottfried Otting
3-Mercapto-2,6-pyridinedicarboxylic acid: a small lanthanide-binding tag for protein studies by NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(12):3827-32.
2010: Gottfried Otting
Protein NMR using paramagnetic ions.
Annual review of biophysics 2010;39():387-405.
2010: Xun-Cheng Su; Gottfried Otting
Paramagnetic labelling of proteins and oligonucleotides for NMR.
Journal of biomolecular NMR 2010;46(1):101-12.
2009: Christophe Bodenreider; David Beer; Thomas H Keller; Sebastian Sonntag; Daying Wen; Lijian Yap; Yin Hoe Yau; Susana Geifman Shochat; Danzhi Huang; Ting Zhou; Amedeo Caflisch; Xun-Cheng Su; Kiyoshi Ozawa; Gottfried Otting; Subhash G Vasudevan; Julien Lescar; Siew Pheng Lim
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.
Analytical biochemistry 2009;395(2):195-204.
2009: Dariusz Ekonomiuk; Xun-Cheng Su; Kiyoshi Ozawa; Christophe Bodenreider; Siew Pheng Lim; Gottfried Otting; Danzhi Huang; Amedeo Caflisch
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
Journal of medicinal chemistry 2009;52(15):4860-8.
2009: Xun-Cheng Su; Haobo Liang; Karin V Loscha; Gottfried Otting
[Ln(DPA)(3)](3-) is a convenient paramagnetic shift reagent for protein NMR studies.
Journal of the American Chemical Society 2009;131(30):10352-3.
2009: Xun-Cheng Su; Kiyoshi Ozawa; Hiromasa Yagi; Siew Pheng Lim; Daying Wen; Dariusz Ekonomiuk; Danzhi Huang; Thomas H Keller; Sebastian Sonntag; Amedeo Caflisch; Subhash G Vasudevan; Gottfried Otting
NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease.
The FEBS journal 2009;276(15):4244-55.
2009: Xinying Jia; Kiyoshi Ozawa; Karin Loscha; Gottfried Otting
Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins.
Journal of biomolecular NMR 2009;44(2):59-67.
2009: Karin V Loscha; Kristaps Jaudzems; Charikleia Ioannou; Xun-Cheng Su; Flynn R Hill; Gottfried Otting; Nicholas E Dixon; Edvards Liepinsh
A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader.
Nucleic acids research 2009;37(7):2395-404.
2009: Xun-Cheng Su; Kiyoshi Ozawa; Ruhu Qi; Subhash G Vasudevan; Siew Pheng Lim; Gottfried Otting
NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease.
PLoS neglected tropical diseases 2009;3(12):e561.
2009: Dariusz Ekonomiuk; Xun-Cheng Su; Kiyoshi Ozawa; Christophe Bodenreider; Siew Pheng Lim; Zheng Yin; Thomas H Keller; David Beer; Viral Patel; Gottfried Otting; Amedeo Caflisch; Danzhi Huang
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
PLoS neglected tropical diseases 2009;3(1):e356.
2008: Gottfried Otting
Prospects for lanthanides in structural biology by NMR.
Journal of biomolecular NMR 2008;42(1):1-9.
2008: Kiyoshi Ozawa; Slobodan Jergic; Ah Young Park; Nicholas E Dixon; Gottfried Otting
The proofreading exonuclease subunit epsilon of Escherichia coli DNA polymerase III is tethered to the polymerase subunit alpha via a flexible linker.
Nucleic acids research 2008;36(15):5074-82.
2008: Xun-Cheng Su; Bradley Man; Sophie Beeren; Haobo Liang; Shane Simonsen; Christophe Schmitz; Thomas Huber; Barbara A Messerle; Gottfried Otting
A dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR spectroscopy.
Journal of the American Chemical Society 2008;130(32):10486-7.
2008: Christophe Schmitz; Mitchell J Stanton-Cook; Xun-Cheng Su; Gottfried Otting; Thomas Huber
Numbat: an interactive software tool for fitting Deltachi-tensors to molecular coordinates using pseudocontact shifts.
Journal of biomolecular NMR 2008;41(3):179-89.
2008: Xun-Cheng Su; Kerry McAndrew; Thomas Huber; Gottfried Otting
Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles.
Journal of the American Chemical Society 2008;130(5):1681-7.
2008: Serin L Dabb; Barbara A Messerle; Gottfried Otting; Jörg Wagler; Anthony Willis
Ruthenium complexes of substituted hydrazine: new solution- and solid-state binding modes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(32):10058-65.
2008: Margit A Apponyi; Kiyoshi Ozawa; Nicholas E Dixon; Gottfried Otting
Cell-free protein synthesis for analysis by NMR spectroscopy.
Methods in molecular biology (Clifton, N.J.) 2008;426():257-68.
2007: Michael John; Gottfried Otting
Strategies for measurements of pseudocontact shifts in protein NMR spectroscopy.
Chemphyschem : a European journal of chemical physics and physical chemistry 2007;8(16):2309-13.
2007: Michael John; Christophe Schmitz; Ah Young Park; Nicholas E Dixon; Thomas Huber; Gottfried Otting
Sequence-specific and stereospecific assignment of methyl groups using paramagnetic lanthanides.
Journal of the American Chemical Society 2007;129(44):13749-57.
2007: Stephen J Watt; Margaret M Sheil; Jennifer L Beck; Pavel Prosselkov; Gottfried Otting; Nicholas E Dixon
Effect of protein stabilization on charge state distribution in positive- and negative-ion electrospray ionization mass spectra.
Journal of the American Society for Mass Spectrometry 2007;18(9):1605-11.
2007: Xun-Cheng Su; Slobodan Jergic; Kiyoshi Ozawa; Nicolas Dale Burns; Nicholas E Dixon; Gottfried Otting
Measurement of dissociation constants of high-molecular weight protein-protein complexes by transferred 15N-relaxation.
Journal of biomolecular NMR 2007;38(1):65-72.
2007: Guido Pintacuda; Michael John; Xun-Cheng Su; Gottfried Otting
NMR structure determination of protein-ligand complexes by lanthanide labeling.
Accounts of chemical research 2007;40(3):206-12.
2007: Michael John; Ah Young Park; Nicholas E Dixon; Gottfried Otting
NMR detection of protein 15N spins near paramagnetic lanthanide ions.
Journal of the American Chemical Society 2007;129(3):462-3.
2007: Xun-Cheng Su; Slobodan Jergic; Max A Keniry; Nicholas E Dixon; Gottfried Otting
Solution structure of Domains IVa and V of the tau subunit of Escherichia coli DNA polymerase III and interaction with the alpha subunit.
Nucleic acids research 2007;35(9):2825-32.
2007: Peter S C Wu; Kiyoshi Ozawa; Siew P Lim; Subhash G Vasudevan; Nicholas E Dixon; Gottfried Otting
Cell-free transcription/translation from PCR-amplified DNA for high-throughput NMR studies.
Angewandte Chemie (International ed. in English) 2007;46(18):3356-8.
2007: Slobodan Jergic; Kiyoshi Ozawa; Neal K Williams; Xun-Cheng Su; Daniel D Scott; Samir M Hamdan; Jeffrey A Crowther; Gottfried Otting; Nicholas E Dixon
The unstructured C-terminus of the tau subunit of Escherichia coli DNA polymerase III holoenzyme is the site of interaction with the alpha subunit.
Nucleic acids research 2007;35(9):2813-24.
2007: Michael John; Madeleine J Headlam; Nicholas E Dixon; Gottfried Otting
Assignment of paramagnetic (15)N-HSQC spectra by heteronuclear exchange spectroscopy.
Journal of biomolecular NMR 2007;37(1):43-51.
2006: Xun-Cheng Su; Patrick M Schaeffer; Karin V Loscha; Pamela H P Gan; Nicholas E Dixon; Gottfried Otting
Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase.
The FEBS journal 2006;273(21):4997-5009.
2006: Michael John; Guido Pintacuda; Ah Young Park; Nicholas E Dixon; Gottfried Otting
Structure determination of protein-ligand complexes by transferred paramagnetic shifts.
Journal of the American Chemical Society 2006;128(39):12910-6.
2006: Xun-Cheng Su; Thomas Huber; Nicholas E Dixon; Gottfried Otting
Site-specific labelling of proteins with a rigid lanthanide-binding tag.
Chembiochem : a European journal of chemical biology 2006;7(10):1599-604.
2006: Kiyoshi Ozawa; Peter S C Wu; Nicholas E Dixon; Gottfried Otting
N-Labelled proteins by cell-free protein synthesis. Strategies for high-throughput NMR studies of proteins and protein-ligand complexes.
The FEBS journal 2006;273(18):4154-9.
2006: Christophe Schmitz; Michael John; Ah Young Park; Nicholas E Dixon; Gottfried Otting; Guido Pintacuda; Thomas Huber
Efficient chi-tensor determination and NH assignment of paramagnetic proteins.
Journal of biomolecular NMR 2006;35(2):79-87.
2006: Max A Keniry; Ah Young Park; Elisabeth A Owen; Samir M Hamdan; Guido Pintacuda; Gottfried Otting; Nicholas E Dixon
Structure of the theta subunit of Escherichia coli DNA polymerase III in complex with the epsilon subunit.
Journal of bacteriology 2006;188(12):4464-73.
2006: Edvards Liepinsh; Alinda Nagy; Mária Trexler; László Patthy; Gottfried Otting
Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein.
Journal of biomolecular NMR 2006;35(1):73-8.
2006: Edvards Liepinsh; László Bányai; László Patthy; Gottfried Otting
NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.
Journal of molecular biology 2006;357(3):942-50.
2006: Guido Pintacuda; Ah Young Park; Max A Keniry; Nicholas E Dixon; Gottfried Otting
Lanthanide labeling offers fast NMR approach to 3D structure determinations of protein-protein complexes.
Journal of the American Chemical Society 2006;128(11):3696-702.
2006: Peter S C Wu; Kiyoshi Ozawa; Slobodan Jergic; Xun-Cheng Su; Nicholas E Dixon; Gottfried Otting
Amino-acid type identification in 15N-HSQC spectra by combinatorial selective 15N-labelling.
Journal of biomolecular NMR 2006;34(1):13-21.
2005: Michael John; Ah Young Park; Guido Pintacuda; Nicholas E Dixon; Gottfried Otting
Weak alignment of paramagnetic proteins warrants correction for residual CSA effects in measurements of pseudocontact shifts.
Journal of the American Chemical Society 2005;127(49):17190-1.
2005: Adam F Hastings; Gottfried Otting; Rutger H A Folmer; Iain Duggin; R Gerry Wake; Matthew C J Wilce; Jackie A Wilce
Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy.
Biochemical and biophysical research communications 2005;335(2):361-6.
2005: Kiyoshi Ozawa; Nicholas E Dixon; Gottfried Otting
Cell-free synthesis of 15N-labeled proteins for NMR studies.
IUBMB life 2005;57(9):615-22.
2005: Peter S C Wu; Gottfried Otting
Rapid pulse length determination in high-resolution NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;176(1):115-9.
2005: Peter S C Wu; Gottfried Otting
SWET for secure water suppression on probes with high quality factor.
Journal of biomolecular NMR 2005;32(3):243-50.
2005: Kiyoshi Ozawa; Slobodan Jergic; Jeffrey A Crowther; Phillip R Thompson; Gene Wijffels; Gottfried Otting; Nicholas A Dixon
Cell-free protein synthesis in an autoinduction system for NMR studies of protein-protein interactions.
Journal of biomolecular NMR 2005;32(3):235-41.
2005: Kiyoshi Ozawa; Madeleine J Headlam; Dmitri Mouradov; Stephen J Watt; Jennifer L Beck; Kenneth J Rodgers; Roger T Dean; Thomas Huber; Gottfried Otting; Nicholas E Dixon
Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins.
The FEBS journal 2005;272(12):3162-71.
2005: Aaron J Oakley; Karin V Loscha; Patrick M Schaeffer; Edvards Liepinsh; Guido Pintacuda; Matthew C J Wilce; Gottfried Otting; Nicholas E Dixon
Crystal and solution structures of the helicase-binding domain of Escherichia coli primase.
The Journal of biological chemistry 2005;280(12):11495-504.
2005: Andrew Robinson; Peter S C Wu; Stephen J Harrop; Patrick M Schaeffer; Zsuzsanna Dosztányi; Michael R Gillings; Andrew J Holmes; K M Helena Nevalainen; HW Stokes; Gottfried Otting; Nicholas E Dixon; Paul M G Curmi; Bridget C Mabbutt
Integron-associated mobile gene cassettes code for folded proteins: the structure of Bal32a, a new member of the adaptable alpha+beta barrel family.
Journal of molecular biology 2005;346(5):1229-41.
2005: Neal K Williams; Edvards Liepinsh; Stephen J Watt; Pavel Prosselkov; Jacqueline M Matthews; Phil Attard; Jennifer L Beck; Nicholas E Dixon; Gottfried Otting
Stabilization of native protein fold by intein-mediated covalent cyclization.
Journal of molecular biology 2005;346(4):1095-108.
2005: Mie Moriya; Shunichiro Taniguchi; Peter Wu; Edvards Liepinsh; Gottfried Otting; Junji Sagara
Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.
Biochemistry 2005;44(2):575-83.
2004: Masaru Hoshino; Gottfried Otting
Sensitivity-enhanced double-TROSY experiment for simultaneous measurement of one-bond 15N-1H, 15N-13C' and two-bond 1H-13C' couplings.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;171(2):270-6.
2004: Guido Pintacuda; Andrei Kaikkonen; Gottfried Otting
Modulation of the distance dependence of paramagnetic relaxation enhancements by CSA x DSA cross-correlation.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;171(2):233-43.
2004: Edvards Liepinsh; Marija Rakonjac Ryge; Vincent Boissonneault; Patrick Provost; Bengt Samuelsson; Olof Rådmark; Gottfried Otting
NMR structure of human coactosin-like protein.
Journal of biomolecular NMR 2004;30(3):353-6.
2004: Kiyoshi Ozawa; Madeleine J Headlam; Patrick M Schaeffer; Blair R Henderson; Nicholas E Dixon; Gottfried Otting
Optimization of an Escherichia coli system for cell-free synthesis of selectively N-labelled proteins for rapid analysis by NMR spectroscopy.
European journal of biochemistry / FEBS 2004;271(20):4084-93.
2004: Guido Pintacuda; Ahmad Moshref; Ainars Leonchiks; Anatoly Sharipo; Gottfried Otting
Site-specific labelling with a metal chelator for protein-structure refinement.
Journal of biomolecular NMR 2004;29(3):351-61.
2004: Guido Pintacuda; Max A Keniry; Thomas Huber; Ah Young Park; Nicholas E Dixon; Gottfried Otting
Fast structure-based assignment of 15N HSQC spectra of selectively 15N-labeled paramagnetic proteins.
Journal of the American Chemical Society 2004;126(9):2963-70.
2004: Karin V Loscha; Aaron J Oakley; Bogdan Bancia; Patrick M Schaeffer; Pavel Prosselkov; Gottfried Otting; Matthew C J Wilce; Nicholas E Dixon
Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase.
Protein expression and purification 2004;33(2):304-10.
2004: Kristofer Modig; Edvards Liepinsh; Gottfried Otting; Bertil Halle
Dynamics of protein and peptide hydration.
Journal of the American Chemical Society 2004;126(1):102-14.
2003: Edvards Liepinsh; Raitis Barbals; Edgar Dahl; Anatoly Sharipo; Eike Staub; Gottfried Otting
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition.
Journal of molecular biology 2003;332(5):1155-63.
2003: Shin-ichi Usami; Kentaro Takahashi; Isamu Yuge; Akihiro Ohtsuka; Atsushi Namba; Satoko Abe; Erik Fransen; László Patthy; Gottfried Otting; Guy Van Camp
Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease.
European journal of human genetics : EJHG 2003;11(10):744-8.
2003: Guido Pintacuda; Karin Hohenthanner; Gottfried Otting; Norbert Müller
Angular dependence of dipole-dipole-Curie-spin cross-correlation effects in high-spin and low-spin paramagnetic myoglobin.
Journal of biomolecular NMR 2003;27(2):115-32.
2003: Edvards Liepinsh; Laszlo Banyai; Guido Pintacuda; Mária Trexler; László Patthy; Gottfried Otting
NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding.
The Journal of biological chemistry 2003;278(28):25982-9.
2003: Edvards Liepinsh; Catherine Généreux; Dominique Dehareng; Bernard Joris; Gottfried Otting
NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.
Journal of molecular biology 2003;327(4):833-42.
2003: Edvards Liepinsh; Ainars Leonchiks; Anatoly Sharipo; Laurent Guignard; Gottfried Otting
Solution structure of the R3H domain from human Smubp-2.
Journal of molecular biology 2003;326(1):217-23.
2002: Laurent Guignard; Kiyoshi Ozawa; Sharon E Pursglove; Gottfried Otting; Nicholas E Dixon
NMR analysis of in vitro-synthesized proteins without purification: a high-throughput approach.
FEBS letters 2002;524(1-3):159-62.
2002: Massimo Bellanda; Evaristo Peggion; Gottfried Otting; Johan Weigelt; Elisabetta Perdona; Enrico Domenici; Carla Marchioro; Stefano Mammi
Backbone 1H, 13C and 15N resonance assignment of the N-terminal 24 kDa fragment of the gyrase B subunit from E. coli.
Journal of biomolecular NMR 2002;22(4):369-70.
2002: Neal K Williams; Pavel Prosselkov; Edvards Liepinsh; Inara Line; Anatoly Sharipo; Dene R Littler; Paul M G Curmi; Gottfried Otting; Nicholas E Dixon
In vivo protein cyclization promoted by a circularly permuted Synechocystis sp. PCC6803 DnaB mini-intein.
The Journal of biological chemistry 2002;277(10):7790-8.
2002: Edvards Liepinsh; Gottfried Otting; Margaret M Harding; Leanne Stephenson; Joel Mackay; A D J Haymet
Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein.
European journal of biochemistry / FEBS 2002;269(4):1259-66.
2002: Guido Pintacuda; Gottfried Otting
Identification of protein surfaces by NMR measurements with a pramagnetic Gd(III) chelate.
Journal of the American Chemical Society 2002;124(3):372-3.
2001: Edvards Liepinsh; Mária Trexler; Andrei Kaikkonen; Johan Weigelt; László Bányai; László Patthy; Gottfried Otting
NMR structure of the LCCL domain and implications for DFNA9 deafness disorder.
The EMBO journal 2001;20(19):5347-53.
2001: Edvards Liepinsh; Mikhail Baryshev; Anatoly Sharipo; Magnus Ingelman-Sundberg; Gottfried Otting; Souren Mkrtchian
Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.
Structure (London, England : 1993) 2001;9(6):457-71.
2001: Andrei Kaikkonen; Gottfried Otting
Sensitive 1H-31P correlations with 5' methylene protons of DNA via homonuclear double-quantum coherence.
Journal of biomolecular NMR 2001;19(3):273-7.
2001: Jackie A Wilce; Julian P Vivian; Adam F Hastings; Gottfried Otting; Rutger H A Folmer; Iain Duggin; R Gerry Wake; Matthew C J Wilce
Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest.
Nature structural biology 2001;8(3):206-10.
2001: Andrei Kaikkonen; Gottfried Otting
Residual dipolar (1)H-(1)H couplings of methyl groups in weakly aligned proteins.
Journal of the American Chemical Society 2001;123(8):1770-1.
2000: Kerstin Nordstrand; A Sandström; F Aslund; Arne Holmgren; Gottfried Otting; Kurt D Berndt
NMR structure of oxidized glutaredoxin 3 from Escherichia coli.
Journal of molecular biology 2000;303(3):423-32.
2000: Samir M Hamdan; Susan E Brown; Phillip R Thompson; Ji Yeon Yang; Paul D Carr; David L Ollis; Gottfried Otting; Nicholas E Dixon
Preliminary X-ray crystallographic and NMR studies on the exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III.
Journal of structural biology 2000;131(2):164-9.
2000: P Andersson; Gottfried Otting
Time-shared X(omega(1))-half-filter for improved sensitivity in subspectral editing.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2000;144(1):168-70.
2000: Gottfried Otting; M Rückert; M H Levitt; Ahmad Moshref
NMR experiments for the sign determination of homonuclear scalar and residual dipolar couplings.
Journal of biomolecular NMR 2000;16(4):343-6.
2000: Rutger H A Folmer; Gottfried Otting
Sensitivity enhancement in (HCA)CONH experiments.
Journal of biomolecular NMR 2000;16(3):229-33.
1999: Maria A Miteva; M Andersson; Andrey Karshikoff; Gottfried Otting
Molecular electroporation: a unifying concept for the description of membrane pore formation by antibacterial peptides, exemplified with NK-lysin.
FEBS letters 1999;462(1-2):155-8.
1999: Johan Weigelt; Susan E Brown; CS Miles; Nicholas E Dixon; Gottfried Otting
NMR structure of the N-terminal domain of E. coli DnaB helicase: implications for structure rearrangements in the helicase hexamer.
Structure (London, England : 1993) 1999;7(6):681-90.
1999: Kerstin Nordstrand; F Aslund; S Meunier; Arne Holmgren; Gottfried Otting; Kurt D Berndt
Direct NMR observation of the Cys-14 thiol proton of reduced Escherichia coli glutaredoxin-3 supports the presence of an active site thiol-thiolate hydrogen bond.
FEBS letters 1999;449(2-3):196-200.
1999: Kerstin Nordstrand; F slund; Arne Holmgren; Gottfried Otting; Kurt D Berndt
NMR structure of Escherichia coli glutaredoxin 3-glutathione mixed disulfide complex: implications for the enzymatic mechanism.
Journal of molecular biology 1999;286(2):541-52.
1999: Leodevico L Ilag; C Rottenberger; Edvards Liepinsh; G Wellnhofer; Fritz Rudert; Gottfried Otting; L L Ilag
Selection of a peptide ligand to the p75 neurotrophin receptor death domain and determination of its binding sites by NMR.
Biochemical and biophysical research communications 1999;255(1):104-9.
1999: Edvards Liepinsh; Gottfried Otting
Water-protein NOEs: Optimized scheme for selective water excitation.
Journal of biomolecular NMR 1999;13(1):73-6.
1998: Ainars Leonchiks; Edvards Liepinsh; M Barishev; Anatoly Sharipo; Maria Masucci; Gottfried Otting
Random coil conformation of a Gly/Ala-rich insert in IkappaB alpha excludes structural stabilization as the mechanism for protection against proteasomal degradation.
FEBS letters 1998;440(3):365-9.
1998: Alexandre Bonvin; Maria Sunnerhagen; Gottfried Otting; Wilfred F van Gunsteren
Water molecules in DNA recognition II: a molecular dynamics view of the structure and hydration of the trp operator.
Journal of molecular biology 1998;282(4):859-73.
1998: Maria Sunnerhagen; Vladimir P Denisov; Kandadai Venu; Alexandre Bonvin; J Carey; Bertil Halle; Gottfried Otting
Water molecules in DNA recognition I: hydration lifetimes of trp operator DNA in solution measured by NMR spectroscopy.
Journal of molecular biology 1998;282(4):847-58.
1998: P Andersson; Johan Weigelt; Gottfried Otting
Spin-state selection filters for the measurement of heteronuclear one-bond coupling constants.
Journal of biomolecular NMR 1998;12(3):435-41.
1998: H Ponstingl; Gottfried Otting
Rapid measurement of scalar three-bond 1HN-1H alpha spin coupling constants in 15N-labelled proteins.
Journal of biomolecular NMR 1998;12(2):319-24.
1998: P Andersson; Kerstin Nordstrand; Maria Sunnerhagen; Edvards Liepinsh; I Turovskis; Gottfried Otting
Heteronuclear correlation experiments for the determination of one-bond coupling constants.
Journal of biomolecular NMR 1998;11(4):445-50.
1998: P Andersson; Bernard Gsell; B Wipf; Hans Senn; Gottfried Otting
HMQC and HSQC experiments with water flip-back optimized for large proteins.
Journal of biomolecular NMR 1998;11(3):279-88.
1998: Johan Weigelt; CS Miles; Nicholas E Dixon; Gottfried Otting
Backbone NMR assignments and secondary structure of the N-terminal domain of DnaB helicase from E. coli.
Journal of biomolecular NMR 1998;11(2):233-4.
1998: Edvards Liepinsh; M Kitamura; T Murakami; T Nakaya; Gottfried Otting
Common ancestor of serine proteases and flavin-binding domains.
Nature structural biology 1998;5(2):102-3.
1997: Maria Sunnerhagen; Michael Nilges; Gottfried Otting; J Carey
Solution structure of the DNA-binding domain and model for the complex of multifunctional hexameric arginine repressor with DNA.
Nature structural biology 1997;4(10):819-26.
1997: Edvards Liepinsh; M Andersson; J M Ruysschaert; Gottfried Otting
Saposin fold revealed by the NMR structure of NK-lysin.
Nature structural biology 1997;4(10):793-5.
1997: Edvards Liepinsh; Leodevico L Ilag; Gottfried Otting; C F Ibáñez
NMR structure of the death domain of the p75 neurotrophin receptor.
The EMBO journal 1997;16(16):4999-5005.
1997: Gottfried Otting; Edvards Liepinsh; Bertil Halle; U Frey
NMR identification of hydrophobic cavities with low water occupancies in protein structures using small gas molecules.
Nature structural biology 1997;4(5):396-404.
1997: H Ponstingl; Gottfried Otting
NMR assignments, secondary structure and hydration of oxidized Escherichia coli flavodoxin.
European journal of biochemistry / FEBS 1997;244(2):384-99.
1997: CS Miles; Johan Weigelt; N P Stamford; N Dammerova; Gottfried Otting; Nicholas E Dixon
Precise limits of the N-terminal domain of DnaB helicase determined by NMR spectroscopy.
Biochemical and biophysical research communications 1997;231(1):126-30.
1996: A Hammarström; Kurt D Berndt; Rannar Sillard; Knut Adermann; Gottfried Otting
Solution structure of a naturally-occurring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit.
Biochemistry 1996;35(39):12723-32.
1996: F Aslund; Kerstin Nordstrand; Kurt D Berndt; M Nikkola; T Bergman; H Ponstingl; Hans Jörnvall; Gottfried Otting; Arne Holmgren
Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis.
The Journal of biological chemistry 1996;271(12):6736-45.
1996: Johan Weigelt; A Hammarstroem; W Bermel; Gottfried Otting
Removal of zero-quantum coherence in protein NMR spectra using SESAM decoupling and suppression of decoupling sidebands.
Journal of magnetic resonance. Series B 1996;110(2):219-24.
1996: Kerstin Nordstrand; H Ponstingl; Arne Holmgren; Gottfried Otting
Resonance assignment and structural analysis of acid denatured E. coli [U-15N]-glutaredoxin 3: use of 3D 15N-HSQC-(TOCSY-NOESY)-15N-HSQC.
European biophysics journal : EBJ 1996;24(3):179-84.
1996: Edvards Liepinsh; Gottfried Otting
Proton exchange rates from amino acid side chains--implications for image contrast.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;35(1):30-42.
1995: Rolf Eliasson; Peter Reichard; Etienne Mulliez; S Ollagnier; Marc Fontecave; Edvards Liepinsh; Gottfried Otting
The mechanism of the anaerobic Escherichia coli ribonucleotide reductase investigated with nuclear magnetic resonance spectroscopy.
Biochemical and biophysical research communications 1995;214(1):28-35.
1995: Gottfried Otting; Edvards Liepinsh
Selective excitation of intense solvent signals in the presence of radiation damping.
Journal of biomolecular NMR 1995;5(4):420-6.
1994: Walter J Gehring; Y Q Qian; M Billeter; Katsuo Furukubo-Tokunaga; A F Schier; D Resendez-Perez; Markus Affolter; Gottfried Otting; Kurt Wüthrich
Homeodomain-DNA recognition.
Cell 1994;78(2):211-23.
1994: Edvards Liepinsh; W Leupin; Gottfried Otting
Hydration of DNA in aqueous solution: NMR evidence for a kinetic destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments.
Nucleic acids research 1994;22(12):2249-54.
1994: Edvards Liepinsh; Kurt D Berndt; Rannar Sillard; V Mutt; Gottfried Otting
Solution structure and dynamics of PEC-60, a protein of the Kazal type inhibitor family, determined by nuclear magnetic resonance spectroscopy.
Journal of molecular biology 1994;239(1):137-53.
1994: P Sevilla-Sierra; Gottfried Otting; Kurt Wüthrich
Determination of the nuclear magnetic resonance structure of the DNA-binding domain of the P22 c2 repressor (1 to 76) in solution and comparison with the DNA-binding domain of the 434 repressor.
Journal of molecular biology 1994;235(3):1003-20.
1993: M Billeter; Y Q Qian; Gottfried Otting; M Müller; W Gehring; Kurt Wüthrich
Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.
Journal of molecular biology 1993;234(4):1084-93.
1993: Y Q Qian; Gottfried Otting; M Billeter; M Müller; W Gehring; Kurt Wüthrich
Nuclear magnetic resonance spectroscopy of a DNA complex with the uniformly 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain.
Journal of molecular biology 1993;234(4):1070-83.
1993: R M Brunne; Edvards Liepinsh; Gottfried Otting; Kurt Wüthrich; Wilfred F van Gunsteren
Hydration of proteins. A comparison of experimental residence times of water molecules solvating the bovine pancreatic trypsin inhibitor with theoretical model calculations.
Journal of molecular biology 1993;231(4):1040-8.
1993: B Leiting; Raffaele De Francesco; Licia tomei; Riccardo Cortese; Gottfried Otting; Kurt Wüthrich
The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain.
The EMBO journal 1993;12(5):1797-803.
1993: Gottfried Otting; Edvards Liepinsh; Kurt Wüthrich
Disulfide bond isomerization in BPTI and BPTI(G36S): an NMR study of correlated mobility in proteins.
Biochemistry 1993;32(14):3571-82.
1993: Edvards Liepinsh; H Rink; Gottfried Otting; Kurt Wüthrich
Contributions from hydration of carboxylate groups to the spectrum of water-polypeptide proton-proton Overhauser effects in aqueous solution.
Journal of biomolecular NMR 1993;3(2):253-7.
1993: Thomas Szyperski; P Luginbühl; Gottfried Otting; Peter Güntert; Kurt Wüthrich
Protein dynamics studied by rotating frame 15N spin relaxation times.
Journal of biomolecular NMR 1993;3(2):151-64.
1992: Edvards Liepinsh; Gottfried Otting; Kurt Wüthrich
NMR observation of individual molecules of hydration water bound to DNA duplexes: direct evidence for a spine of hydration water present in aqueous solution.
Nucleic acids research 1992;20(24):6549-53.
1992: Y Q Qian; Gottfried Otting; Katsuo Furukubo-Tokunaga; Markus Affolter; Walter J Gehring; Kurt Wüthrich
NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10738-42.
1992: Edvards Liepinsh; Gottfried Otting; Kurt Wüthrich
NMR spectroscopy of hydroxyl protons in aqueous solutions of peptides and proteins.
Journal of biomolecular NMR 1992;2(5):447-65.
1992: Thomas Szyperski; D Neri; B Leiting; Gottfried Otting; Kurt Wüthrich
Support of 1H NMR assignments in proteins by biosynthetically directed fractional 13C-labeling.
Journal of biomolecular NMR 1992;2(4):323-34.
1992: M Billeter; D Neri; Gottfried Otting; Y Q Qian; Kurt Wüthrich
Precise vicinal coupling constants 3JHN alpha in proteins from nonlinear fits of J-modulated [15N,1H]-COSY experiments.
Journal of biomolecular NMR 1992;2(3):257-74.
1992: Kurt Wüthrich; Gottfried Otting; Edvards Liepinsh
Protein hydration in aqueous solution.
Faraday discussions 1992;(93):35-45.
1991: Gottfried Otting; Edvards Liepinsh; Kurt Wüthrich
Protein hydration in aqueous solution.
Science (New York, N.Y.) 1991;254(5034):974-80.
1991: Gottfried Otting; Edvards Liepinsh; B T Farmer; Kurt Wüthrich
Protein hydration studied with homonuclear 3D 1H NMR experiments.
Journal of biomolecular NMR 1991;1(2):209-15.
1991: Markus Affolter; A Percival-Smith; M Müller; M Billeter; Y Q Qian; Gottfried Otting; Kurt Wüthrich; Walter J Gehring
Similarities between the homeodomain and the Hin recombinase DNA-binding domain.
Cell 1991;64(5):879-80.
1991: Peter Güntert; Y Q Qian; Gottfried Otting; M Müller; W Gehring; Kurt Wüthrich
Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA.
Journal of molecular biology 1991;217(3):531-40.
1990: Walter J Gehring; M Müller; Markus Affolter; A Percival-Smith; M Billeter; Y Q Qian; Gottfried Otting; Kurt Wüthrich
The structure of the homeodomain and its functional implications.
Trends in genetics : TIG 1990;6(10):323-9.
1990: Gottfried Otting; Y Q Qian; M Billeter; M Müller; Markus Affolter; Walter J Gehring; Kurt Wüthrich
Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution.
The EMBO journal 1990;9(10):3085-92.
1990: M Billeter; Y Qian; Gottfried Otting; M Müller; Walter J Gehring; Kurt Wüthrich
Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy.
Journal of molecular biology 1990;214(1):183-97.
1990: W Leupin; Gottfried Otting; H Amacker; Kurt Wüthrich
Application of 13C(omega 1)-half-filtered [1H,1H]-NOESY for studies of a complex formed between DNA and a 13C-labeled minor-groove-binding drug.
FEBS letters 1990;263(2):313-6.
1989: Y Q Qian; M Billeter; Gottfried Otting; M Müller; Walter J Gehring; Kurt Wüthrich
The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors.
Cell 1989;59(3):573-80.
1989: D Neri; Thomas Szyperski; Gottfried Otting; Hans Senn; Kurt Wüthrich
Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling.
Biochemistry 1989;28(19):7510-6.
1988: Gottfried Otting; Y Q Qian; M Müller; Markus Affolter; W Gehring; Kurt Wüthrich
Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif.
The EMBO journal 1988;7(13):4305-9.
1988: M Müller; Markus Affolter; W Leupin; Gottfried Otting; Kurt Wüthrich; Walter J Gehring
Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.
The EMBO journal 1988;7(13):4299-304.
1988: R Grütter; Gottfried Otting; Kurt Wüthrich; W Leupin
OR3 operator of bacteriophage lambda in a 23 base-pair DNA fragment: sequence-specific 1H NMR assignments for the non-labile protons and comparison with the isolated 17 base-pair operator.
European biophysics journal : EBJ 1988;16(5):279-86.
1987: Gottfried Otting; Pascale Marchot; Pierre E Bougis; Hervé Rochat; Kurt Wüthrich
Monitoring the purification by high-performance liquid chromatography of cardiotoxins from Naja mossambica mossambica using phase-sensitive two-dimensional nuclear magnetic resonance.
European journal of biochemistry / FEBS 1987;168(3):603-7.
1987: Gottfried Otting; W E Steinmetz; Pierre E Bougis; Hervé Rochat; Kurt Wüthrich
Sequence-specific 1H-NMR assignments and determination of the secondary structure in aqueous solution of the cardiotoxins CTXIIa and CTXIIb from Naja mossambica mossambica.
European journal of biochemistry / FEBS 1987;168(3):609-20.
1987: Gottfried Otting; R Grütter; W Leupin; C Minganti; K N Ganesh; B S Sproat; M J Gait; Kurt Wüthrich
Sequential NMR assignments of labile protons in DNA using two-dimensional nuclear-Overhauser-enhancement spectroscopy with three jump-and-return pulse sequences.
European journal of biochemistry / FEBS 1987;166(1):215-20.
1987: Hans Senn; A Eugster; Gottfried Otting; F Suter; Kurt Wüthrich
15N-labeled P22 c2 repressor for nuclear magnetic resonance studies of protein-DNA interactions.
European biophysics journal : EBJ 1987;14(5):301-6.