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Markus Otto

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Mirko Bibl; Hermann Esselmann; Johannes Kornhuber; Piotr Lewczuk; Brit Mollenhauer; Markus Otto; Holger Schmidt; Volker Welge; Jens Wiltfang
Plasma amyloid-beta peptides in acute cerebral ischemia: a pilot study.
Stefan Lehnert; Martin Lenter; Patrick Oeckl; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Sarah Jesse; Wolfgang Rist; Hilkka Soininen; Petra Steinacker; Hayrettin Tumani; Markus Otto
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia.
Sarah Jesse; Hans A Kretzschmar; Hasan Kulaksiz; Stefan Lehnert; Martin Lenter; Manuela Neumann; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Olaf Jahn; Lucilla Parnetti; Hilkka Soininen; Petra Steinacker; Saskia Tawfik; Hayrettin Tumani; Christine A F Von Arnim; Jens Wiltfang; Markus Otto
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.

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2012: Mirko Bibl; Hermann Esselmann; Johannes Kornhuber; Piotr Lewczuk; Brit Mollenhauer; Markus Otto; Holger Schmidt; Volker Welge; Jens Wiltfang
Plasma amyloid-beta peptides in acute cerebral ischemia: a pilot study.
Journal of clinical laboratory analysis 2012;26(4):238-45.
2012: Stefan Lehnert; Martin Lenter; Patrick Oeckl; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Sarah Jesse; Wolfgang Rist; Hilkka Soininen; Petra Steinacker; Hayrettin Tumani; Markus Otto
iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia.
Experimental neurology 2012;234(2):499-505.
2012: Sarah Jesse; Hans A Kretzschmar; Hasan Kulaksiz; Stefan Lehnert; Martin Lenter; Manuela Neumann; Boris Ferger; Bastian Hengerer; Sanna-Kaisa Herukka; Olaf Jahn; Lucilla Parnetti; Hilkka Soininen; Petra Steinacker; Saskia Tawfik; Hayrettin Tumani; Christine A F Von Arnim; Jens Wiltfang; Markus Otto
Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.
PloS one 2012;7(11):e48783.
2012: Luc Dupuis; Wilhelm Fischer; Torsten Grehl; Julian Grosskreutz; Michael T Heneka; Andreas Hermann; Jan Kassubek; Eva Lindauer; Albert C Ludolph; Thomas Meyer; Markus Otto; Bertold Schrank; Franziska Steiner; Carsten Wessig; Andrea S Winkler; Stephan Zierz; Reiner Benecke; Ulrich Bogdahn; Reinhard Dengler; Jens Dreyhaupt
A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis.
PloS one 2012;7(6):e37885.
2012: Markus Otto; Lucilla Parnetti; Axel Petzold; Pamela Shaw; Alexander Sherman; Petra Steinacker; Sigurd D Süssmuth; Charlotte Teunissen; Hayrettin Tumani; Martin Turner; Anna Wuolikainen; James Berry; Robert Bowser; Johannes Brettschneider; James Connor; Júlia Costa; Merit Cudkowicz; Jonathan Glass; Olaf Jahn; Stefan Lehnert; Albert Ludolph; Andrea Malaspina
Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2012;13(1):1-10.
2012: Elena Lebedeva; Albert C Ludolph; Markus Otto; Esra Özer; Matthias W Riepe; Julia C Stingl; Joachim Strauss; Dietmar R Thal; Hayrettin Tumani; Lars Bertram; Estifanos Ghebremedhin; Josef Högel; Björn von Einem; Christine A F Von Arnim
Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD.
Neurobiology of aging 2012;33(1):201.e9-18.
2011: Petra Steinacker; Alastair Aitken; Markus Otto
14-3-3 proteins in neurodegeneration.
Seminars in cell & developmental biology 2011;22(7):696-704.
2011: Hayrettin Tumani; Brigitte Wildemann; Florian Deisenhammer; Gavin Giovannoni; Ralf Gold; Hans-Peter Hartung; Bernhard Hemmer; Reinhard Hohlfeld; Markus Otto; Martin Stangel; Uwe K Zettl
Revised McDonald criteria: the persisting importance of cerebrospinal fluid analysis.
Annals of neurology 2011;70(3):520; author reply 521.
2011: Markus Otto; M Schroeter; Adrian Danek; J Diehl-Schmid; hans förstl; J Kornhuber; Hans A Kretzschmar; B Landwehrmeyer; Albert C Ludolph; Manuela Neumann
[German consortium for frontotemporal lobar degeneration].
Der Nervenarzt 2011;82(8):1002-5.
2011: Sarah Jesse; Johannes Brettschneider; Sigurd D Süssmuth; Bernhard G Landwehrmeyer; Christine A F Von Arnim; Albert C Ludolph; Hayrettin Tumani; Markus Otto
Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases.
Journal of neurology 2011;258(6):1034-41.
2011: Brit Mollenhauer; Hermann Esselmann; Sigrun Roeber; Walter J Schulz-Schaeffer; Claudia Trenkwalder; Mirko Bibl; Petra Steinacker; Hans A Kretzschmar; Jens Wiltfang; Markus Otto
Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(5):691-7.
2011: Philipp Spitzer; Jens Wiltfang; Davide Chiasserini; Sanna-Kaisa Herukka; Heike Kamrowski-Kruck; Markus Otto; Lucilla Parnetti; Heinke Schieb; Johannes Schuchhardt; Hans-Wolfgang Klafki
Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia.
International journal of Alzheimer's disease 2011;2011():739847.
2011: Klaus Jung; Peter Lange; Roland Nau; Markus Otto; Joachim Blocher; Marija Djukic; Joachim Gerber; Christoph Goerdt; Annette Spreer; Holger Schmidt
The use of S100B and Tau protein concentrations in the cerebrospinal fluid for the differential diagnosis of bacterial meningitis: a retrospective analysis.
European neurology 2011;66(3):128-32.
2011: Petra Steinacker; Hayrettin Tumani; Lubin Fang; Jens Kuhle; Albert C Ludolph; Markus Otto; Axel Petzold; Johannes Brettschneider
Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis.
PloS one 2011;6(8):e23600.
2011: Brit Mollenhauer; Hermann Esselmann; Claudia Trenkwalder; Walter Schulz-Schaeffer; Hans A Kretzschmar; Markus Otto; Jens Wiltfang; Mirko Bibl
CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;24(2):383-91.
2011: Mirko Bibl; Brit Mollenhauer; Piotr Lewczuk; Hermann Esselmann; Stefanie Wolf; Markus Otto; Johannes Kornhuber; Eckart Rüther; Jens Wiltfang
Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias.
Dementia and geriatric cognitive disorders 2011;31(1):37-44.
2010: Mohamad Reza Mohamadi; Zuzana Svobodova; Romain Verpillot; Hermann Esselmann; Jens Wiltfang; Markus Otto; Myriam Taverna; Zuzana Bilkova; Jean-Louis Viovy
Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer's disease.
Analytical chemistry 2010;82(18):7611-7.
2010: Sigurd D Süssmuth; Ingo Uttner; Bernhard Landwehrmeyer; Elmar H Pinkhardt; Johannes Brettschneider; Axel Petzold; Bernd Kramer; Jörg B Schulz; Christian Palm; Markus Otto; Albert C Ludolph; Jan Kassubek; Hayrettin Tumani
Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
Movement disorders : official journal of the Movement Disorder Society 2010;25(9):1284-8.
2010: Hauke Schmidt; Joachim Gerber; K Stuertz; Marija Djukic; Stephanie Bunkowski; FR Fischer; Markus Otto; Roland Nau
S100B in the cerebrospinal fluid--a marker for glial damage in the rabbit model of pneumococcal meningitis.
Neuroscience letters 2010;475(2):104-7.
2010: Petra Steinacker; Andreas Hawlik; Stefan Lehnert; Olaf Jahn; Stephen Meier; E Görz; Kerstin Braunstein; Marija Krzovska; Birgit Schwalenstöcker; Sarah Jesse; Christian Pröpper; Tobias Böckers; Albert Ludolph; Markus Otto
Neuroprotective function of cellular prion protein in a mouse model of amyotrophic lateral sclerosis.
The American journal of pathology 2010;176(3):1409-20.
2010: Hayrettin Tumani; Vera Lehmensiek; Stefan Lehnert; Markus Otto; Johannes Brettschneider
2D DIGE of the cerebrospinal fluid proteome in neurological diseases.
Expert review of proteomics 2010;7(1):29-38.
2010: Philipp Spitzer; Hans-Wolfgang Klafki; Kaj Blennow; Luc BUEE; Hermann Esselmann; Sanna-Kaisa Herruka; Connie Jimenez; Peter Klivenyi; Piotr Lewczuk; Juan Manuel Maler; Katrin Markus; Helmut E Meyer; Chris Morris; Thorsten Müller; Markus Otto; Lucilla Parnetti; Hilkka Soininen; Susanna Schraen; Charlotte Teunissen; Laszlo Vecsei; Henrik Zetterberg; Jens Wiltfang
cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases.
International journal of Alzheimer's disease 2010;2010():.
2010: Mirko Bibl; Hermann Esselmann; Piotr Lewczuk; Claudia Trenkwalder; Markus Otto; Johannes Kornhuber; Jens Wiltfang; Brit Mollenhauer
Combined Analysis of CSF Tau, Aβ42, Aβ1-42% and Aβ1-40% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia.
International journal of Alzheimer's disease 2010;2010():.
2010: Petra Steinacker; Hans Klafki; Stefan Lehnert; Sarah Jesse; Christine A F V Arnim; Hayrettin Tumani; Alice Pabst; Hans A Kretzschmar; Jens Wiltfang; Markus Otto
ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients.
Journal of Alzheimer's disease : JAD 2010;22(1):119-28.
2010: Johannes Brettschneider; Anne Czerwoniak; Makbule Senel; Lubin Fang; Jan Kassubek; Elmar Pinkhardt; Florian Lauda; Tamara Kapfer; Sarah Jesse; Vera Lehmensiek; Albert C Ludolph; Markus Otto; Hayrettin Tumani
The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS).
PloS one 2010;5(8):e11986.
2010: Sarah Jesse; Petra Steinacker; Stefan Lehnert; Martin Sdzuj; Lukas Cepek; Hayrettin Tumani; Olaf Jahn; Holger Schmidt; Markus Otto
A proteomic approach for the diagnosis of bacterial meningitis.
PloS one 2010;5(4):e10079.
2010: Petra Steinacker; Wolfgang Rist; Magdalena Swiatek-de Lange; Stefan Lehnert; Sarah Jesse; Alice Pabst; Hayrettin Tumani; Christine A F Von Arnim; Eva Mitrova; Hans A Kretzschmar; Martin Lenter; Jens Wiltfang; Markus Otto
Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease.
Proteomics 2010;10(1):81-9.
2009: Petra Steinacker; Corinna Hendrich; Anne-Dorte Sperfeld; Sarah Jesse; Stefan Lehnert; Alice Pabst; Christine A F Von Arnim; Felix M Mottaghy; Ingo Uttner; Hayrettin Tumani; Albert Ludolph; Markus Otto
Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(9):1169-78.
2009: Volker Welge; Oliver Fiege; Piotr Lewczuk; Brit Mollenhauer; Hermann Esselmann; Hans-Wolfgang Klafki; Stefanie Wolf; Claudia Trenkwalder; Markus Otto; Johannes Kornhuber; Jens Wiltfang; Mirko Bibl
Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(2):203-12.
2009: Johannes Brettschneider; Hayrettin Tumani; Ulrike Kiechle; Rainer Muche; Gayle Richards; Vera Lehmensiek; Albert C Ludolph; Markus Otto
IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome.
PloS one 2009;4(11):e7638.
2009: Ralf A Linker; Peter Brechlin; Sarah Jesse; Petra Steinacker; D H Lee; Abdul R Asif; Olaf Jahn; Hayrettin Tumani; Ralf Gold; Markus Otto
Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage.
PloS one 2009;4(10):e7624.
2009: Sarah Jesse; Petra Steinacker; Lukas Cepek; Christine A F Von Arnim; Hayrettin Tumani; Stefan Lehnert; Hans A Kretzschmar; Michael Baier; Markus Otto
Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease.
Journal of Alzheimer's disease : JAD 2009;17(3):541-51.
2009: Sarah Jesse; Petra Steinacker; Stefan Lehnert; Frank Gillardon; Bastian Hengerer; Markus Otto
Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review.
CNS neuroscience & therapeutics 2009;15(2):157-82.
2008: Petra Steinacker; Corinna Hendrich; Anne-Dorte Sperfeld; Sarah Jesse; Christine A F Von Arnim; Stefan Lehnert; Alice Pabst; Ingo Uttner; Hayrettin Tumani; Virginia M-Y Lee; John Q Trojanowski; Hans A Kretzschmar; Albert C Ludolph; Manuela Neumann; Markus Otto
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology 2008;65(11):1481-7.
2008: Piotr Lewczuk; Joachim Hornegger; Rüdiger Zimmermann; Markus Otto; Jens Wiltfang; Johannes Kornhuber
Neurochemical dementia diagnostics: assays in CSF and blood.
European archives of psychiatry and clinical neuroscience 2008;258 Suppl 5():44-9.
2008: Mirko Bibl; Piotr Lewczuk; Hermann Esselmann; Brit Mollenhauer; Hans-Wolfgang Klafki; Volker Welge; Stefanie Wolf; Claudia Trenkwalder; Markus Otto; Johannes Kornhuber; Jens Wiltfang
CSF amyloid-β 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction.
Proteomics. Clinical applications 2008;2(10-11):1548-56.
2008: Hayrettin Tumani; Charlotte Teunissen; Sigurd D Süssmuth; Markus Otto; Albert C Ludolph; Johannes Brettschneider
Cerebrospinal fluid biomarkers of neurodegeneration in chronic neurological diseases.
Expert review of molecular diagnostics 2008;8(4):479-94.
2008: Piotr Lewczuk; Johannes Kornhuber; hugo vanderstichele; Eugeen Vanmechelen; Hermann Esselmann; Mirko Bibl; Stefanie Wolf; Markus Otto; Udo Reulbach; Heike Kölsch; Frank Jessen; Johannes Schröder; Peter Schönknecht; Harald Hampel; Oliver Peters; Erik Weimer; Robert Perneczky; Holger Jahn; Christian Luckhaus; Ulrich Lamla; Tillmann Supprian; Juan Manuel Maler; Jens Wiltfang
Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study.
Neurobiology of aging 2008;29(6):812-8.
2008: Markus Otto; Piotr Lewczuk; Jens Wiltfang
Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases.
Methods (San Diego, Calif.) 2008;44(4):289-98.
2008: Hans-Jürgen Gdynia; Timo Müller; Anne-Dorte Sperfeld; Peter Kühnlein; Markus Otto; Jan Kassubek; Albert C Ludolph
Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6.
Neuromuscular disorders : NMD 2008;18(2):156-8.
2008: Markus Uhrig; Peter Brechlin; Olaf Jahn; Yuri Knyazev; Annette Weninger; Laura Busia; Kamran Honarnejad; Markus Otto; Tobias Hartmann
Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential.
BMC medicine 2008;6():38.
2007: Mirko Bibl; Hermann Esselmann; Brit Mollenhauer; Godehard Weniger; Volker Welge; Michael Liess; Piotr Lewczuk; Markus Otto; Jörg B Schulz; Claudia Trenkwalder; Johannes Kornhuber; Jens Wiltfang
Blood-based neurochemical diagnosis of vascular dementia: a pilot study.
Journal of neurochemistry 2007;103(2):467-74.
2007: Mirko Bibl; Brit Mollenhauer; Piotr Lewczuk; Hermann Esselmann; S Wolf; Claudia Trenkwalder; Markus Otto; Gerthild Stiens; Eckart Rüther; Johannes Kornhuber; Jens Wiltfang
Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.
Molecular psychiatry 2007;12(7):671-80.
2007: Brit Mollenhauer; Mirko Bibl; H Esselmann; Petra Steinacker; Claudia Trenkwalder; Jens Wiltfang; Markus Otto
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(7):919-27.
2007: Brit Mollenhauer; Petra Steinacker; Erik Bahn; Mirko Bibl; Peter Brechlin; Michael G Schlossmacher; Joseph J Locascio; Jens Wiltfang; Hans A Kretzschmar; Sigrid Poser; Claudia Trenkwalder; Markus Otto
Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies.
Neuro-degenerative diseases 2007;4(5):366-75.
2007: Lukas Cepek; Peter Brechlin; Petra Steinacker; Brit Mollenhauer; Enrico Klingebiel; Mirko Bibl; Hans A Kretzschmar; Jens Wiltfang; Markus Otto
Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Dementia and geriatric cognitive disorders 2007;23(1):22-8.
2006: Piotr Lewczuk; Georg Beck; Oliver Ganslandt; Hermann Esselmann; Florian Deisenhammer; Axel Regeniter; Hela-Felicitas Petereit; Hayrettin Tumani; Andreas Gerritzen; Patrick Oschmann; Johannes Schröder; Peter Schönknecht; Klaus Zimmermann; Harald Hampel; Katharina Bürger; Markus Otto; Sabine Haustein; Karin Herzog; Rainer Dannenberg; Ulrich Wurster; Mirko Bibl; Juan Manuel Maler; Udo Reubach; Johannes Kornhuber; Jens Wiltfang
International quality control survey of neurochemical dementia diagnostics.
Neuroscience letters 2006;409(1):1-4.
2006: Mirko Bibl; Brit Mollenhauer; Hermann Esselmann; Piotr Lewczuk; Claudia Trenkwalder; Peter Brechlin; Eckart Rüther; Johannes Kornhuber; Markus Otto; Jens Wiltfang
CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(11):1771-8.
2006: Brit Mollenhauer; Mirko Bibl; Hermann Esselmann; Petra Steinacker; Claudia Trenkwalder; Peter Brechlin; J Wiltfang; Markus Otto
Selective reduction of amyloid beta42 discriminates Alzheimer's disease from Huntington's disease: indication for distinct pathological events in amyloid beta peptide aggregation.
Journal of neurology, neurosurgery, and psychiatry 2006;77(10):1201-3.
2006: Mirko Bibl; Brit Mollenhauer; Hermann Esselmann; Piotr Lewczuk; Hans-Wolfgang Klafki; Katrin Sparbier; Alexandr Smirnov; Lukas Cepek; Claudia Trenkwalder; Eckart Rüther; Johannes Kornhuber; Markus Otto; Jens Wiltfang
CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia.
Brain : a journal of neurology 2006;129(Pt 5):1177-87.
2006: Brit Mollenhauer; Claudia Trenkwalder; Nicolas von Ahsen; Mirko Bibl; Petra Steinacker; Peter Brechlin; Jan Schindehuette; Sigrid Poser; Jens Wiltfang; Markus Otto
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.
Dementia and geriatric cognitive disorders 2006;22(3):200-8.
2006: Brit Mollenhauer; Mirko Bibl; Jens Wiltfang; Petra Steinacker; Barbara Ciesielczyk; Karin Neubert; Claudia Trenkwalder; Markus Otto
Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(2):192-5.
2005: Andreas Meier; Brit Mollenhauer; Stefan Cohrs; Andrea Rodenbeck; Wolfgang Jordan; Johannes Meller; Markus Otto
Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease.
Brain research 2005;1063(2):201-3.
2005: Kevin Rostasy; Esther Withut; Daniela Pohl; Peter Lange; Barbara Ciesielcyk; Ricarda Diem; Jutta Gärtner; Markus Otto
Tau, phospho-tau, and S-100B in the cerebrospinal fluid of children with multiple sclerosis.
Journal of child neurology 2005;20(10):822-5.
2005: Brit Mollenhauer; Mirko Bibl; Claudia Trenkwalder; Gerthild Stiens; Lukas Cepek; Petra Steinacker; Barbara Ciesielczyk; Karin Neubert; Jens Wiltfang; Hans A Kretzschmar; Sigrid Poser; Markus Otto
Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(7):933-48.
2005: Stefan Bleich; Markus Otto; Inga Zerr; Stefan Kropp; Hans A Kretzschmar; Jens Wiltfang
Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid.
Gerontology 2005;51(2):142-4.
2005: Petra Steinacker; Petra Schwarz; Kerstin Reim; Peter Brechlin; Olaf Jahn; Hartmut Kratzin; Alastair Aitken; Jens Wiltfang; Adriano Aguzzi; Erik Bahn; Helen C Baxter; Nils Brose; Markus Otto
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Molecular and cellular biology 2005;25(4):1339-46.
2005: Jens Wiltfang; Piotr Lewczuk; Peter Riederer; Edna Grünblatt; Christoph Hock; Philip scheltens; Harald Hampel; hugo vanderstichele; Khalid Iqbal; Douglas Galasko; Lars Lannfelt; Markus Otto; Hermann Esselmann; Andreas Wolfram Henkel; Johannes Kornhuber; Kaj Blennow
Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2005;6(2):69-84.
2005: Lukas Cepek; Petra Steinacker; Brit Mollenhauer; Birgitt Wiese; Barbara Ciesielczyk; Mirko Bibl; Jens Wiltfang; Inga Zerr; Walter Schulz-Schaeffer; Hans A Kretzschmar; Sigrid Poser; Markus Otto
Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Dementia and geriatric cognitive disorders 2005;19(5-6):376-82.
2005: Brit Mollenhauer; Lukas Cepek; Mirko Bibl; Jens Wiltfang; Walter Schulz-Schaeffer; Barbara Ciesielczyk; Manuela Neumann; Petra Steinacker; Hans A Kretzschmar; Sigrid Poser; Claudia Trenkwalder; Markus Otto
Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies.
Dementia and geriatric cognitive disorders 2005;19(2-3):164-70.
2004: Petra Steinacker; Brit Mollenhauer; Mirko Bibl; Lukas Cepek; Hermann Esselmann; Peter Brechlin; Piotr Lewczuk; Sigrid Poser; Hans A Kretzschmar; Jens Wiltfang; Claudia Trenkwalder; Markus Otto
Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases.
Neuroscience letters 2004;370(1):36-9.
2004: Piotr Lewczuk; Hermann Esselmann; Mirko Bibl; Sabine Paul; Jana Svitek; Johannes Miertschischk; Robert Meyrer; Alexandr Smirnov; Juan Manuel Maler; Christian Klein; Markus Otto; Stefan Bleich; Wolfgang Sperling; Johannes Kornhuber; Eckart Rüther; Jens Wiltfang
Electrophoretic separation of amyloid beta peptides in plasma.
Electrophoresis 2004;25(20):3336-43.
2004: Mirko Bibl; Hermann Esselmann; Markus Otto; Piotr Lewczuk; Lukas Cepek; Eckart Rüther; Johannes Kornhuber; Jens Wiltfang
Cerebrospinal fluid amyloid beta peptide patterns in Alzheimer's disease patients and nondemented controls depend on sample pretreatment: indication of carrier-mediated epitope masking of amyloid beta peptides.
Electrophoresis 2004;25(17):2912-8.
2004: Julia Schultz; Anja Schwarz; Sabine Neidhold; Michael Burwinkel; Constanze Riemer; Dietrich Simon; Manfred Kopf; Markus Otto; Michael Baier
Role of interleukin-1 in prion disease-associated astrocyte activation.
The American journal of pathology 2004;165(2):671-8.
2004: Markus Otto; Lukas Cepek; Peter Ratzka; S Doehlinger; I Boekhoff; Jens Wiltfang; Eva Irle; G Pergande; B Ellers-Lenz; Otto Windl; Hans A Kretzschmar; Sigrid Poser; Hilmar Prange
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.
Neurology 2004;62(5):714-8.
2004: Piotr Lewczuk; Hermann Esselmann; Markus Otto; Juan Manuel Maler; Andreas Wolfram Henkel; Maria Kerstin Henkel; Oliver Eikenberg; Christof Antz; Wolf-Rainer Krause; Udo Reulbach; Johannes Kornhuber; Jens Wiltfang
Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.
Neurobiology of aging 2004;25(3):273-81.
2004: Piotr Lewczuk; Hermann Esselmann; Teja Wolfgang Groemer; Mirko Bibl; Juan Manuel Maler; Petra Steinacker; Markus Otto; Johannes Kornhuber; Jens Wiltfang
Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease.
Biological psychiatry 2004;55(5):524-30.
2004: Hermann Esselmann; Juan Manuel Maler; N Kunz; Markus Otto; S Paul; Piotr Lewczuk; Eckart Rüther; Johannes Kornhuber; Jens Wiltfang
Lithium decreases secretion of Abeta1-42 and C-truncated species Abeta1-37/38/39/40 in chicken telencephalic cultures but specifically increases intracellular Abeta1-38.
Neuro-degenerative diseases 2004;1(4-5):236-41.
2004: Piotr Lewczuk; Hermann Esselmann; Mirko Bibl; Georg Beck; Juan Manuel Maler; Markus Otto; Johannes Kornhuber; Jens Wiltfang
Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature.
Journal of molecular neuroscience : MN 2004;23(1-2):115-22.
2004: H Schmidt; Markus Otto; Paul Dieter Niedmann; Lukas Cepek; Andreas Schröter; Hans A Kretzschmar; Sigrid Poser
CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias.
Dementia and geriatric cognitive disorders 2004;17(3):204-6.
2003: Jens Wiltfang; Hermann Esselmann; Alexandr Smirnov; Mirko Bibl; Lukas Cepek; Petra Steinacker; Brit Mollenhauer; Katharina Buerger; Harald Hampel; Sabine Paul; Manuela Neumann; Manuel Maler; Inga Zerr; Johannes Kornhuber; Hans A Kretzschmar; Sigrid Poser; Markus Otto
Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Annals of neurology 2003;54(2):263-7.
2003: Peter Ratzka; Susanne Döhlinger; Lukas Cepek; Petra Steinacker; Sönke Arlt; Christian Jacobi; Andreas Schröter; Jens Wiltfang; Hilmar Prange; Hans A Kretzschmar; Sigrid Poser; Markus Otto
Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.
Neuroscience letters 2003;343(1):29-32.
2003: Markus Otto; Jens Wiltfang
Differential diagnosis of neurodegenerative diseases with special emphasis on Creutzfeldt-Jakob disease.
Restorative neurology and neuroscience 2003;21(3-4):191-209.
2003: Piotr Lewczuk; Hermann Esselmann; Markus Meyer; Volker Wollscheid; Manuela Neumann; Markus Otto; Juan Manuel Maler; Eckart Rüther; Johannes Kornhuber; Jens Wiltfang
The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide.
Rapid communications in mass spectrometry : RCM 2003;17(12):1291-6.
2002: Lienhard Maeck; Johannes Meller; Markus Otto; Gerthild Stiens; Jens Wiltfang; Gabriela Stoppe
Abeta peptide 1-42, Tau protein and S-100B protein level in cerebrospinal fluid of three patients with primary progressive aphasia.
Neuroscience letters 2002;333(1):33-6.
2002: Helen C Baxter; Janet R Fraser; Wing Gee Liu; J L Forster; Samuel J Clokie; Petra Steinacker; Markus Otto; Erik Bahn; Jens Wiltfang; Alastair Aitken
Specific 14-3-3 isoform detection and immunolocalization in prion diseases.
Biochemical Society transactions 2002;30(4):387-91.
2002: Jens Wiltfang; Hermann Esselmann; Mirko Bibl; Alexandr Smirnov; Markus Otto; Sabine Paul; B Schmidt; Hans-Wolfgang Klafki; Manuel Maler; T Dyrks; M Bienert; M Beyermann; Eckart Rüther; Johannes Kornhuber
Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.
Journal of neurochemistry 2002;81(3):481-96.
2002: Markus Otto; Jens Wiltfang; Lukas Cepek; Manuela Neumann; Brit Mollenhauer; Petra Steinacker; Barbara Ciesielczyk; Walter Schulz-Schaeffer; Hans A Kretzschmar; Sigrid Poser
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease.
Neurology 2002;58(2):192-7.
2002: Andreas Bitsch; Claudia Horn; Yvonne Kemmling; Maria Seipelt; Uwe Hellenbrand; Michael Stiefel; Barbara Ciesielczyk; Lukas Cepek; Erik Bahn; Peter Ratzka; Hilmar Prange; Markus Otto
Serum tau protein level as a marker of axonal damage in acute ischemic stroke.
European neurology 2002;47(1):45-51.
2001: Peter Ratzka; Andreas Schröter; Lukas Cepek; Karsten Henkel; Jens Wiltfang; Hans A Kretzschmar; Hilmar Prange; Sigrid Poser; Markus Otto
Unaltered apoptotic behaviour of mononuclear cells from patients with sporadic Creutzfeldt-Jakob disease.
Journal of neurology 2001;248(8):690-4.
2000: Stefan Bleich; Stefan Kropp; Detlef Degner; Inga Zerr; Jürgen Pilz; Christoph H Gleiter; Markus Otto; Eckart Rüther; Hans A Kretzschmar; Jens Wiltfang; Johannes Kornhuber; Sigrid Poser
Creutzfeldt-Jakob disease and oxidative stress.
Acta neurologica Scandinavica 2000;101(5):332-4.
2000: Markus Otto; Hermann Esselmann; W Schulz-Shaeffer; Manuela Neumann; Andreas Schröter; Peter Ratzka; Lukas Cepek; Inga Zerr; Petra Steinacker; Otto Windl; Johannes Kornhuber; Hans A Kretzschmar; Sigrid Poser; Jens Wiltfang
Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neurology 2000;54(5):1099-102.
2000: Sigrid Poser; Inga Zerr; A Schroeter; Markus Otto; Armin Giese; Bernhard J Steinhoff; Hans A Kretzschmar
Clinical and differential diagnosis of Creutzfeldt-Jakob disease.
Archives of virology. Supplementum 2000;(16):153-9.
1999: Jens Wiltfang; Wilhelm Nolte; Markus Otto; J Wildberg; Erik Bahn; Hans R Figulla; Lars Pralle; H Hartmann; Eckart Rüther; Giuliano Ramadori
Elevated serum levels of astroglial S100beta in patients with liver cirrhosis indicate early and subclinical portal-systemic encephalopathy.
Metabolic brain disease 1999;14(4):239-51.
1999: Jens Wiltfang; Markus Otto; Helen C Baxter; Monika Bodemer; Petra Steinacker; Erik Bahn; Inga Zerr; Johannes Kornhuber; Hans A Kretzschmar; Sigrid Poser; Eckart Rüther; Alastair Aitken
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Journal of neurochemistry 1999;73(6):2485-90.
1999: Michael Beekes; Markus Otto; Jens Wiltfang; Erik Bahn; Sigrid Poser; Michael Baier
Late increase of serum S100 beta protein levels in hamsters after oral or intraperitoneal infection with scrapie.
The Journal of infectious diseases 1999;180(2):518-20.
1998: Markus Otto; Michael Beekes; Jens Wiltfang; Erik Bahn; Sigrid Poser; H Diringer
Elevated levels of serum S100 beta protein in scrapie hamsters.
Journal of neurovirology 1998;4(5):572-3.
1998: Markus Otto; Jens Wiltfang; E Schütz; Inga Zerr; A Otto; A Pfahlberg; Olaf Gefeller; M Uhr; Armin Giese; T Weber; Hans A Kretzschmar; Sigrid Poser
Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study.
BMJ (Clinical research ed.) 1998;316(7131):577-82.
1998: Markus Otto; Erik Bahn; J Wiltfang; I Boekhoff; W Beuche
Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis.
Neuroscience letters 1998;240(3):171-3.
1998: Inga Zerr; Monika Bodemer; Olaf Gefeller; Markus Otto; Sigrid Poser; Jens Wiltfang; Otto Windl; Hans A Kretzschmar; T Weber
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Annals of neurology 1998;43(1):32-40.
1997: Markus Otto; H Stein; A Szudra; Inga Zerr; Monika Bodemer; Olaf Gefeller; Sigrid Poser; Hans A Kretzschmar; Michael Mäder; T Weber
S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Journal of neurology 1997;244(9):566-70.
1997: Markus Otto; Jens Wiltfang; Hayrettin Tumani; Inga Zerr; M Lantsch; Johannes Kornhuber; T Weber; Hans A Kretzschmar; Sigrid Poser
Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neuroscience letters 1997;225(3):210-2.
1996: Inga Zerr; Monika Bodemer; Markus Otto; Sigrid Poser; Otto Windl; Hans A Kretzschmar; Olaf Gefeller; T Weber
Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid.
Lancet 1996;348(9031):846-9.
1996: T Weber; Stephan Frye; Monika Bodemer; Markus Otto; Wolfgang Lüke
Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system.
Journal of neurovirology 1996;2(3):175-90.