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Michael Otto

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Peiyuan Wang; Veronique Zennou; Donghui Bao; Phillip A Furman; Meg Keilman; Congrong Niu; Michael J Otto; Suguna Rachakonda; Bruce S Ross; Michael J Sofia
Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.
Angela M Lam; Holly M Micolochick Steuer; Michael J Otto; Veronique Zennou; Shalini Bansal; Christine Espiritu; Phillip A Furman
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
Peiyuan Wang; Phillip A Furman; Ralph T Mosley; Devan Naduthambi; Congrong Niu; Michael J Otto; Michael J Sofia
Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.

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2012: Peiyuan Wang; Veronique Zennou; Donghui Bao; Phillip A Furman; Meg Keilman; Congrong Niu; Michael J Otto; Suguna Rachakonda; Bruce S Ross; Michael J Sofia
Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.
Antiviral chemistry & chemotherapy 2012;22(5):217-38.
2011: Angela M Lam; Holly M Micolochick Steuer; Michael J Otto; Veronique Zennou; Shalini Bansal; Christine Espiritu; Phillip A Furman
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
Journal of virology 2011;85(23):12334-42.
2011: Peiyuan Wang; Phillip A Furman; Ralph T Mosley; Devan Naduthambi; Congrong Niu; Michael J Otto; Michael J Sofia
Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.
Bioorganic & medicinal chemistry letters 2011;21(15):4642-7.
2011: Phillip A Furman; Meg Keilman; Angela M Lam; Holly Micolochick Steuer; Eisuke Murakami; Congrong Niu; Michael J Otto; Bruce S Ross; Shalini Bansal; Haiying Bao; Nigel Bourne; Wonsuk Chang; Jinfa Du; Christine Espiritu; Tatiana Tolstykh; Ronald L Veselenak; Veronique Zennou; Michael J Sofia
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
Antiviral research 2011;91(2):120-32.
2011: Angela M Lam; Christine Espiritu; Eisuke Murakami; Veronique Zennou; Shalini Bansal; Holly M Micolochick Steuer; Congrong Niu; Meg Keilman; Haiying Bao; Nigel Bourne; Ronald L Veselenak; P Ganapati Reddy; Wonsuk Chang; Jinfa Du; Dhanapalan Nagarathnam; Michael J Sofia; Michael J Otto; Phillip A Furman
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Antimicrobial agents and chemotherapy 2011;55(6):2566-75.
2010: P Ganapati Reddy; Donghui Bao; Wonsuk Chang; AJR Chun; Jinfa Du; Dhanapalan Nagarathnam; Suguna Rachakonda; Bruce S Ross; Hai-Ren Zhang; Shalini Bansal; Christine L Espiritu; Meg Keilman; Angela M Lam; Congrong Niu; Holly Micolochick Steuer; Phillip A Furman; Michael J Otto; Michael J Sofia
2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorganic & medicinal chemistry letters 2010;20(24):7376-80.
2010: Michael J Sofia; Donghui Bao; Wonsuk Chang; Jinfa Du; Dhanapalan Nagarathnam; Suguna Rachakonda; P Ganapati Reddy; Bruce S Ross; Peiyuan Wang; Hai-Ren Zhang; Shalini Bansal; Christine Espiritu; Meg Keilman; Angela M Lam; Holly M Micolochick Steuer; Congrong Niu; Michael J Otto; Phillip A Furman
Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
Journal of medicinal chemistry 2010;53(19):7202-18.
2010: Angela M Lam; Eisuke Murakami; Christine Espiritu; Holly M Micolochick Steuer; Congrong Niu; Meg Keilman; Haiying Bao; Veronique Zennou; Nigel Bourne; Justin G Julander; John D Morrey; Donald F Smee; David N Frick; Julie A Heck; Peiyuan Wang; Dhanapalan Nagarathnam; Bruce S Ross; Michael J Sofia; Michael J Otto; Phillip A Furman
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Antimicrobial agents and chemotherapy 2010;54(8):3187-96.
2008: Eisuke Murakami; Congrong Niu; Haiying Bao; Holly M Micolochick Steuer; Tony Whitaker; Tammy Nachman; Michael A Sofia; Peiyuan Wang; Michael J Otto; Phillip A Furman
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrobial agents and chemotherapy 2008;52(2):458-64.
2007: Eisuke Murakami; Haiying Bao; Mangala Ramesh; Tamara R McBrayer; Tony Whitaker; Holly M Micolochick Steuer; Ray F Schinazi; Lieven Stuyver; Aleksandr Obikhod; Michael J Otto; Phillip A Furman
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Antimicrobial agents and chemotherapy 2007;51(2):503-9.
2007: Eisuke Murakami; Haiying Bao; Aravind Basavapathruni; Christopher M Bailey; Jinfa Du; Holly M Micolochick Steuer; Congrong Niu; Tony Whitaker; Karen S Anderson; Michael J Otto; Phillip A Furman
Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent.
Antiviral chemistry & chemotherapy 2007;18(2):83-92.
2007: AJR Chun; Peiyuan Wang; Abdalla Hassan; Jinfa Du; Phillip M Tharnish; Eisuke Murakami; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2007;26(1):83-97.
2006: Brent E Korba; Phillip A Furman; Michael J Otto
Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo.
Expert review of anti-infective therapy 2006;4(4):549-61.
2006: Jeremy L Clark; J Christian Mason; Laurent Hollecker; Lieven Stuyver; Phillip M Tharnish; Tamara R McBrayer; Michael J Otto; Phillip A Furman; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
Bioorganic & medicinal chemistry letters 2006;16(6):1712-5.
2006: Lieven Stuyver; Tamara R McBrayer; Phillip M Tharnish; Jeremy Clark; Laurent Hollecker; Stefania Lostia; Tammy Nachman; Jason Grier; Matthew A Bennett; Meng-Yu Xie; Ray F Schinazi; John D Morrey; Justin L Julander; Phillip A Furman; Michael J Otto
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Antiviral chemistry & chemotherapy 2006;17(2):79-87.
2005: Peiyuan Wang; Jinfa Du; Suguna Rachakonda; AJR Chun; Phillip M Tharnish; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.
Journal of medicinal chemistry 2005;48(20):6454-60.
2005: Michal Hocek; Petr Naus; Radek Pohl; Ivan Votruba; Phillip A Furman; Phillip M Tharnish; Michael J Otto
Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.
Journal of medicinal chemistry 2005;48(18):5869-73.
2005: Jeremy L Clark; Laurent Hollecker; J Christian Mason; Lieven Stuyver; Phillip M Tharnish; Stefania Lostia; Tamara R McBrayer; Ray F Schinazi; Kyoichi A Watanabe; Michael J Otto; Phillip A Furman; Wojciech J Stec; Steven E Patterson; Krzysztof W Pankiewicz
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
Journal of medicinal chemistry 2005;48(17):5504-8.
2005: Christian Herzmann; K Arastèh; R L Murphy; Hubert Schulbin; Peter Kreckel; D Drauz; Ray F Schinazi; A Beard; Leanne Cartee; Michael J Otto
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy 2005;49(7):2828-33.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Phillip M Tharnish; Tamara R McBrayer; Lieven Stuyver; Michael J Otto; Chung (David) K. Chu; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.
Bioorganic & medicinal chemistry 2005;13(5):1641-52.
2005: Abdalla E A Hassan; Peiyuan Wang; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Michael J Otto; Kyoichi A Watanabe; Ray F Schinazi
Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1531-42.
2005: Jinfa Du; Laurent Hollecker; Junxing Shi; AJR Chun; Kyoichi A Watanabe; F Schinazi Raymond; Tammy Y Nachman; Stefania Lostia; Lieven Stuyver; Michael J Otto
N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.
Nucleosides, nucleotides & nucleic acids 2005;24(8):1209-14.
2005: Abdalla E A Hassan; Peiyuan Wang; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Ray F Schinazi; Michael J Otto; Kyoichi A Watanabe
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):961-4.
2005: Peiyuan Wang; Laurent Hollecker; Krzysztof W Pankiewicz; Steven E Patterson; Tony Whitaker; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Ray F Schinazi; Michael J Otto; Kyoichi A Watanabe
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):957-60.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Abdalla E A Hassan; Phillip M Tharnish; Tamara R McBrayer; Stefania Lostia; Lieven Stuyver; Kyoichi A Watanabe; Chung (David) K. Chu; Ray F Schinazi; Michael J Otto
Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):875-9.
2004: Peiyuan Wang; Laurent Hollecker; Krzysztof W Pankiewicz; Steven E Patterson; Tony Whitaker; Tamara R McBrayer; Phillip M Tharnish; Robert W Sidwell; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
Journal of medicinal chemistry 2004;47(24):6100-3.
2004: Lieven Stuyver; Tamara R McBrayer; Dirk Schürmann; Irena Kravec; Amanda Beard; Leanne Cartee; Ray F Schinazi; Abel De La Rosa; Robert L Murphy; Michael J Otto
Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.
Antiviral therapy 2004;9(4):529-36.
2004: Lieven Stuyver; Tamara R McBrayer; Tony Whitaker; Phillip M Tharnish; Mangala Ramesh; Stefania Lostia; Leanne Cartee; Junxing Shi; Ann Hobbs; Ray F Schinazi; Kyoichi A Watanabe; Michael J Otto
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.
Antimicrobial agents and chemotherapy 2004;48(2):651-4.
2004: Dale L Barnard; Valerie D Hubbard; Jared Burton; Donald F Smee; John D Morrey; Michael J Otto; Robert W Sidwell
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine.
Antiviral chemistry & chemotherapy 2004;15(1):15-22.
2003: Youhoon Chong; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Chung (David) K. Chu
Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2003;14(6):309-19.
2003: Lieven Stuyver; Tamara R McBrayer; Phillip M Tharnish; Abdalla E A Hassan; Chung (David) K. Chu; Krzysztof W Pankiewicz; Kyochi A Watanabe; Ray F Schinazi; Michael J Otto
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.
Journal of virology 2003;77(19):10689-94.
2003: Abdalla E A Hassan; Balakrina S Pai; Stefania Lostia; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):891-4.
2003: Junxing Shi; Judy S Mathew; Phillip M Tharnish; Suguna Rachakonda; S Balakrishna Pai; Marjorie Adams; Jason Grier; Karen Gallagher; Hangchun Zhang; Jing-Tao Wu; Guoen Shi; Romas Geleziunas; Susan Erickson-Viitanen; Lieven Stuyver; Michael J Otto; Kyoichi A Watanabe; Ray F Schinazi
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.
Antiviral chemistry & chemotherapy 2003;14(2):81-90.
2003: Romas Geleziunas; Karen Gallagher; Hangchun Zhang; Lee Bacheler; Sena Garber; Jing-Tao Wu; Guoen Shi; Michael J Otto; Ray F Schinazi; Susan Erickson-Viitanen
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
Antiviral chemistry & chemotherapy 2003;14(1):49-59.
2003: Susan Erickson-Viitanen; Jing-Tao Wu; Guoen Shi; Steven Unger; Robert W King; Barbara Fish; Ronald Klabe; Romas Geleziunas; Karen Gallagher; Michael J Otto; Ray F Schinazi
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
Antiviral chemistry & chemotherapy 2003;14(1):39-47.
2003: Lieven Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung (David) K. Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Ray F Schinazi
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrobial agents and chemotherapy 2003;47(1):244-54.
2002: Lieven Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung (David) K. Chu; Michael J Otto; Ray F Schinazi
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrobial agents and chemotherapy 2002;46(12):3854-60.
2002: Lieven Stuyver; Stefania Lostia; Steven E Patterson; Jeremy L Clark; Kyoichi A Watanabe; Michael J Otto; Krzysztof W Pankiewicz
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
Antiviral chemistry & chemotherapy 2002;13(6):345-52.
2002: Ray F Schinazi; John Mellors; Holly Bazmi; Sharon Diamond; Sena Garber; Karen Gallagher; Romas Geleziunas; Ronald Klabe; James Michael Pierce; Marlene Rayner; Jing-Tao Wu; Hangchun Zhang; Jennifer Hammond; Lee Bacheler; Douglas J Manion; Michael J Otto; Lieven Stuyver; George L Trainor; Dennis C Liotta; Susan Erickson-Viitanen
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy 2002;46(5):1394-401.
2000: R B Perni; S C Conway; SK Ladner; K Zaifert; Michael J Otto; Robert W King
Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.
Bioorganic & medicinal chemistry letters 2000;10(23):2687-90.
1998: Robert W King; SK Ladner; TJ Miller; K Zaifert; R B Perni; S C Conway; Michael J Otto
Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine.
Antimicrobial agents and chemotherapy 1998;42(12):3179-86.
1998: SK Ladner; TJ Miller; Michael J Otto; Robert W King
The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues.
Antiviral chemistry & chemotherapy 1998;9(1):65-72.
1997: SK Ladner; Michael J Otto; C S Barker; K Zaifert; G H Wang; Ju-Tao Guo; Christoph Seeger; Robert W King
Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication.
Antimicrobial agents and chemotherapy 1997;41(8):1715-20.
1996: Carl Nicholas Hodge; P E Aldrich; Lee Bacheler; Chong-Hwan Chang; C J Eyermann; Sena Garber; M Grubb; D A Jackson; Prabhakar K Jadhav; BD Korant; Patrick Y S Lam; M B Maurin; J L Meek; Michael J Otto; Marlene Rayner; C Reid; T R Sharpe; L Shum; D L Winslow; Susan Erickson-Viitanen
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
Chemistry & biology 1996;3(4):301-14.
1995: R W King; D L Winslow; Sena Garber; H T Scarnati; L Bachelor; S Stack; Michael J Otto
Identification of a clinical isolate of HIV-1 with an isoleucine at position 82 of the protease which retains susceptibility to protease inhibitors.
Antiviral research 1995;28(1):13-24.
1995: D L Winslow; Michael J Otto
HIV protease inhibitors.
AIDS (London, England) 1995;9 Suppl A():S183-92.
1995: D L Winslow; S Stack; R King; H Scarnati; A Bincsik; Michael J Otto
Limited sequence diversity of the HIV type 1 protease gene from clinical isolates and in vitro susceptibility to HIV protease inhibitors.
AIDS research and human retroviruses 1995;11(1):107-13.
1994: D L Winslow; D Mayers; H Scarnati; J Lane; A Bincsik; Michael J Otto
In vitro susceptibility of clinical isolates of HIV-1 to XM323, a non-peptidyl HIV protease inhibitor.
AIDS (London, England) 1994;8(6):753-6.
1994: Patrick Y S Lam; Prabhakar K Jadhav; C J Eyermann; Carl Nicholas Hodge; Y Ru; Lee Bacheler; J L Meek; Michael J Otto; Marlene Rayner; Y N Wong
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
Science (New York, N.Y.) 1994;263(5145):380-4.
1993: Michael J Otto; C D Reid; Sena Garber; Patrick Y S Lam; H Scarnati; Lee Bacheler; Marlene Rayner; D L Winslow
In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor.
Antimicrobial agents and chemotherapy 1993;37(12):2606-11.
1993: Michael J Otto; Sena Garber; D L Winslow; C D Reid; P Aldrich; Prabhakar K Jadhav; C E Patterson; Carl Nicholas Hodge; Y S Cheng
In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7543-7.
1992: Y S Cheng; C E Patterson; R G Rucker; Michael J Otto; CJ Rizzo; BD Korant
Molecular characterization of HIV-2 (ROD) protease following PCR cloning from virus infected H9 cells.
Advances in experimental medicine and biology 1992;312():83-8.