FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Sigrid Otto

Research Profile

Anatomy

Disorders

HIV Infections

Living Beings

HIV-1

Physiology

Concepts & Ideas

Procedures

CD4 Lymphocyte Count

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Ineke den Braber; Koos Gaiser; Frank Miedema; Ramona Mögling; Tendai Mugwagwa; Erik Mul; Sigrid A Otto; An F C Ruiter; Elise H R Schrijver; Gerrit Spierenburg; Nienke Vrisekoop; Liset Westera; Neeltje Willems; Anne Bregje de Boer; Mariëtte T Ackermans; José A M Borghans; Rob J De Boer; kiki tesselaar
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
Rogier van Gent; Felix Haas; Nicolaas J G Jansen; Frank Miedema; Rutger A J Nievelstein; Sigrid A Otto; Alvin W L Schadenberg; Gertjan T Sieswerda; kiki tesselaar; José A M Borghans
Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?
Beatrijs L P Bloemers; Louis Bont; Roel A de Weger; Sigrid A Otto; José A M Borghans; kiki tesselaar
Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Sigrid Otto (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Ineke den Braber; Koos Gaiser; Frank Miedema; Ramona Mögling; Tendai Mugwagwa; Erik Mul; Sigrid A Otto; An F C Ruiter; Elise H R Schrijver; Gerrit Spierenburg; Nienke Vrisekoop; Liset Westera; Neeltje Willems; Anne Bregje de Boer; Mariëtte T Ackermans; José A M Borghans; Rob J De Boer; kiki tesselaar
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
Immunity 2012;36(2):288-97.
2011: Rogier van Gent; Felix Haas; Nicolaas J G Jansen; Frank Miedema; Rutger A J Nievelstein; Sigrid A Otto; Alvin W L Schadenberg; Gertjan T Sieswerda; kiki tesselaar; José A M Borghans
Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?
Blood 2011;118(3):627-34.
2011: Beatrijs L P Bloemers; Louis Bont; Roel A de Weger; Sigrid A Otto; José A M Borghans; kiki tesselaar
Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4500-7.
2009: R van Gent; CM van Tilburg; E E Nibbelke; Sigrid A Otto; J F Gaiser; P L Janssens-Korpela; Elisabeth A M Sanders; J A M Borghans; N M Wulffraat; Marc Bierings; Andries C Bloem; kiki tesselaar
Refined characterization and reference values of the pediatric T- and B-cell compartments.
Clinical immunology (Orlando, Fla.) 2009;133(1):95-107.
2008: Nienke Vrisekoop; Rogier van Gent; Anne Bregje de Boer; Sigrid A Otto; Jan C C Borleffs; Radjin Steingrover; Jan M Prins; Taco W Kuijpers; Tom F W Wolfs; Sibyl P M Geelen; Irma Vulto; Peter Lansdorp; kiki tesselaar; José A M Borghans; Frank Miedema
Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1573-81.
2007: shivani choudhary; Nienke Vrisekoop; Christine A Jansen; Sigrid A Otto; Hanneke Schuitemaker; Frank Miedema; David Camerini
Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease.
Journal of virology 2007;81(16):8838-42.
2006: José A M Borghans; R G M Bredius; Mette D Hazenberg; Helene Roelofs; Els C Jol-van der Zijde; Jeroen Heidt; Sigrid A Otto; Taco W Kuijpers; Willem E Fibbe; Jaak M Vossen; Frank Miedema; Maarten J D van Tol
Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency.
Blood 2006;108(2):763-9.
2005: Nienke Vrisekoop; Sanjay U C Sankatsing; Christine A Jansen; Marijke Th L Roos; Sigrid A Otto; Hanneke Schuitemaker; Joep M A Lange; Jan M Prins; Frank Miedema
Short communication: No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naive acute and chronic HIV-1-infected patients.
AIDS research and human retroviruses 2005;21(12):991-6.
2005: Fransje Koning; Sigrid A Otto; Mette D Hazenberg; Linda Dekker; Maria Prins; Frank Miedema; Hanneke Schuitemaker
Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6117-22.
2004: Mette D Hazenberg; Sigrid A Otto; Annemarie M C van Rossum; Henriëtte J Scherpbier; Ronald de Groot; Taco W Kuijpers; Joep M A Lange; Dörte Hamann; Rob J De Boer; José A M Borghans; Frank Miedema
Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1.
Blood 2004;104(12):3513-9.
2004: Liselotte van Asten; Figen Danisman; Sigrid A Otto; José A M Borghans; Mette D Hazenberg; Roel A Coutinho; Maria Prins; Frank Miedema
Pre-seroconversion immune status predicts the rate of CD4 T cell decline following HIV infection.
AIDS (London, England) 2004;18(14):1885-93.
2003: Mette D Hazenberg; Sigrid A Otto; Birgit H B van Benthem; Marijke Th L Roos; Roel A Coutinho; Joep M A Lange; Dörte Hamann; Maria Prins; Frank Miedema
Persistent immune activation in HIV-1 infection is associated with progression to AIDS.
AIDS (London, England) 2003;17(13):1881-8.
2003: Mette D Hazenberg; Sigrid A Otto; Dörte Hamann; Marijke Th L Roos; Hanneke Schuitemaker; Rob J De Boer; Frank Miedema
Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation.
AIDS (London, England) 2003;17(10):1419-24.
2003: Ronald P van Rij; Mette D Hazenberg; Birgit H B van Benthem; Sigrid A Otto; Maria Prins; Frank Miedema; Hanneke Schuitemaker
Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolution.
AIDS research and human retroviruses 2003;19(5):389-98.
2002: Mette D Hazenberg; Sigrid A Otto; Ferdinand W N M Wit; Joep M A Lange; Dörte Hamann; Frank Miedema
Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss.
AIDS (London, England) 2002;16(9):1287-9.
2002: Mette D Hazenberg; Sigrid A Otto; Elmar S D de Pauw; Helene Roelofs; Willem E Fibbe; Dörte Hamann; Frank Miedema
T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events.
Blood 2002;99(9):3449-53.
2002: Stefan Kostense; Sigrid A Otto; Gerlinde J Knol; Erik H Manting; Nening M Nanlohy; Christine Jansen; Joep M A Lange; Marinus H J van Oers; Frank Miedema; Debbie Van Baarle
Functional restoration of human immunodeficiency virus and Epstein-Barr virus-specific CD8(+) T cells during highly active antiretroviral therapy is associated with an increase in CD4(+) T cells.
European journal of immunology 2002;32(4):1080-9.
2002: Elmar S D de Pauw; Sigrid A Otto; Juul Wijnen; Jaak M Vossen; Margreet H van Weel; Hans J Tanke; Frank Miedema; Rein Willemze; Helene Roelofs; Willem E Fibbe
Long-term follow-up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic stem cell exhaustion.
British journal of haematology 2002;116(2):491-6.
2002: Hans J J van der Vliet; B Mary E von Blomberg; Mette D Hazenberg; Nobusuke Nishi; Sigrid A Otto; Birgit H B van Benthem; Maria Prins; Frans A Claessen; Alfons J M van den Eertwegh; Giuseppe Giaccone; Frank Miedema; Rik J Scheper; HERBERT PINEDO
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1490-5.
2000: James W T Cohen Stuart; M D Hazebergh; Dörte Hamann; Sigrid A Otto; Jan C C Borleffs; Frank Miedema; Charles A B Boucher; Rob J De Boer
The dominant source of CD4+ and CD8+ T-cell activation in HIV infection is antigenic stimulation.
Journal of acquired immune deficiency syndromes (1999) 2000;25(3):203-11.
2000: Mette D Hazenberg; Sigrid A Otto; James W T Cohen Stuart; M C Verschuren; Jan C C Borleffs; Charles A B Boucher; Roel A Coutinho; Joep M A Lange; Tobias F Rinke de Wit; Aster Tsegaye; Jacques J M van Dongen; Dörte Hamann; Rob J De Boer; Frank Miedema
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection.
Nature medicine 2000;6(9):1036-42.
2000: Mette D Hazenberg; J W Stuart; Sigrid A Otto; Jan C C Borleffs; Charles A B Boucher; Rob J De Boer; Frank Miedema; Dörte Hamann
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).
Blood 2000;95(1):249-55.
1999: Katja C Wolthers; André J Noest; Sigrid A Otto; Frank Miedema; Rob J De Boer
Normal telomere lengths in naive and memory CD4+ T cells in HIV type 1 infection: a mathematical interpretation.
AIDS research and human retroviruses 1999;15(12):1053-62.
1999: Dörte Hamann; Stefan Kostense; Katja C Wolthers; Sigrid A Otto; Paul A Baars; Frank Miedema; René A W van Lier
Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division.
International immunology 1999;11(7):1027-33.
1999: Nadine Pakker; E D Kroon; Marijke Th L Roos; Sigrid A Otto; D Hall; Ferdinand W N M Wit; Dörte Hamann; Marchina E Van Der Ende; Frans A Claessen; Robbert H Kauffmann; Peter P Koopmans; Frank P Kroon; C H ten Napel; Herman Sprenger; Hugo M Weigel; Julio S G Montaner; Joep M A Lange; Peter Reiss; P T A Schellekens; Frank Miedema
Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group.
AIDS (London, England) 1999;13(2):203-12.
1999: Katja C Wolthers; Sigrid A Otto; G B Wisman; Sylvain Fleury; Peter Reiss; R W ten Kate; A G van der Zee; Frank Miedema
Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection.
Blood 1999;93(3):1011-9.
1998: Sylvain Fleury; Rob J De Boer; G Paolo Rizzardi; Katja C Wolthers; Sigrid A Otto; C C Welbon; C Graziosi; C Knabenhans; H Soudeyns; Pierre-Alexandre Bart; S Gallant; Jean-Marc Corpataux; M Gillet; Pascal R A Meylan; P Schnyder; Jean-Yves Meuwly; W Spreen; Michel-Pierre Glauser; Frank Miedema; Giuseppe Pantaleo
Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
Nature medicine 1998;4(7):794-801.
1997: Katja C Wolthers; Sigrid A Otto; SM Lens; René A W van Lier; Frank Miedema; L Meyaard
Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70.
AIDS research and human retroviruses 1997;13(12):1023-9.
1996: Katja C Wolthers; G Bea; A Wisman; Sigrid A Otto; Ana Maria de Roda Husman; N Schaft; Frank de Wolf; Jaap Goudsmit; Roel A Coutinho; A G van der Zee; L Meyaard; Frank Miedema
T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover.
Science (New York, N.Y.) 1996;274(5292):1543-7.
1996: L Meyaard; Egbert Hovenkamp; IP Keet; Berend Hooibrink; I H de Jong; Sigrid A Otto; Frank Miedema
Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2712-8.
1996: Katja C Wolthers; Sigrid A Otto; SM Lens; D N Kolbach; René A W van Lier; Frank Miedema; L Meyaard
Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells.
European journal of immunology 1996;26(8):1700-6.
1996: L Meyaard; Egbert Hovenkamp; Sigrid A Otto; Frank Miedema
IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2776-82.
1995: Aad P van den Berg; L Meyaard; Sigrid A Otto; Willem J Van Son; Ids J Klompmaker; G Mesander; LH de Leij; F Miedema; T Hauw The
Cytomegalovirus infection associated with a decreased proliferative capacity and increased rate of apoptosis of peripheral blood lymphocytes.
Transplantation proceedings 1995;27(1):936-8.
1995: L Meyaard; H Kuiper; Sigrid A Otto; Katja C Wolthers; René A W van Lier; Frank Miedema
Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals.
European journal of immunology 1995;25(1):232-7.
1994: L Meyaard; Sigrid A Otto; IP Keet; René A W van Lier; Frank Miedema
Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection.
Blood 1994;84(12):4262-8.
1994: L Meyaard; Sigrid A Otto; Berend Hooibrink; Frank Miedema
Quantitative analysis of CD4+ T cell function in the course of human immunodeficiency virus infection. Gradual decline of both naive and memory alloreactive T cells.
The Journal of clinical investigation 1994;94(5):1947-52.
1994: L Meyaard; Sigrid A Otto; IP Keet; Marijke Th L Roos; Frank Miedema
Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.
The Journal of clinical investigation 1994;93(3):982-8.
1993: Hanneke Schuitemaker; L Meyaard; Neeltje Kootstra; R Dubbes; Sigrid A Otto; M Tersmette; Jonathan Luke Heeney; Frank Miedema
Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants.
The Journal of infectious diseases 1993;168(5):1140-7.
1992: L Meyaard; Sigrid A Otto; Hanneke Schuitemaker; Frank Miedema
Effects of HIV-1 Tat protein on human T cell proliferation.
European journal of immunology 1992;22(10):2729-32.
1992: L Meyaard; Sigrid A Otto; R R Jonker; M J Mijnster; R P Keet; Frank Miedema
Programmed death of T cells in HIV-1 infection.
Science (New York, N.Y.) 1992;257(5067):217-9.