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Willem Ouwehand

Research Profile

Chemicals & Drugs

Anatomy

Blood Platelets

Disorders

Physiology

Living Beings

Newborn Infant

Genes & Molecular Sequences

Concepts & Ideas

Procedures

Platelet Transfusion

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Publications

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Sophie Garnier; Alison H Goodall; Christian Hengstenberg; Thomas Munzel; Willem H Ouwehand; Maxime Rovital; Nilesh J Samani; Heribert Schunkert; Laurence Tiret; Stefan Blankenberg; Jessy Brocheton; François Cambien; Panos Deloukas; Jeannette Erdmann; Vinh Truong; Philipp S Wild; Tanja Zeller; Andreas Ziegler; David-Alexandre Trégouët
Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes.
Sylvia T Nürnberg; Panos Deloukas; Berthold Gottgens; Joseph E Italiano; Heather Lloyd-Jones; Dirk S Paul; Augusto Rendon; Jennifer G Sambrook; Peter A Smethurst; Nicole Soranzo; Jonathan N Thon; Marloes R Tijssen; Katrin Voss; Willem H Ouwehand
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.
Marina Evangelou; Willem H Ouwehand; Augusto Rendon; Lorenz Wernisch; Frank Dudbridge
Comparison of methods for competitive tests of pathway analysis.

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All Publications

2013: Sophie Garnier; Alison H Goodall; Christian Hengstenberg; Thomas Munzel; Willem H Ouwehand; Maxime Rovital; Nilesh J Samani; Heribert Schunkert; Laurence Tiret; Stefan Blankenberg; Jessy Brocheton; François Cambien; Panos Deloukas; Jeannette Erdmann; Vinh Truong; Philipp S Wild; Tanja Zeller; Andreas Ziegler; David-Alexandre Trégouët
Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes.
PLoS genetics 2013;9(1):e1003240.
2012: Sylvia T Nürnberg; Panos Deloukas; Berthold Gottgens; Joseph E Italiano; Heather Lloyd-Jones; Dirk S Paul; Augusto Rendon; Jennifer G Sambrook; Peter A Smethurst; Nicole Soranzo; Jonathan N Thon; Marloes R Tijssen; Katrin Voss; Willem H Ouwehand
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.
Blood 2012;120(24):4859-68.
2012: Marina Evangelou; Willem H Ouwehand; Augusto Rendon; Lorenz Wernisch; Frank Dudbridge
Comparison of methods for competitive tests of pathway analysis.
PloS one 2012;7(7):e41018.
2012: Suthesh Sivapalaratnam; Brigitte M Sondermeijer; Nicholas A Watkins; Hanneke Basart; Esther E Creemers; Alison H Goodall; Kees Hovingh; John J P Kastelein; Unni Krishnan; Stepanie Maiwald; Willem H Ouwehand; Sara-Joan Pinto-Sietsma; Augusto Rendon; Mieke D Trip
Monocyte gene expression signature of patients with early onset coronary artery disease.
PloS one 2012;7(2):e32166.
2011: Jovana Serbanovic-Canic; Nicole Soranzo; Derek L Stemple; Ana Cvejic; Willem H Ouwehand; Kathleen Freson
Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.
Blood 2011;118(18):4967-76.
2011: Cornelis A Albers; Marie-Christine Alessi; Paul Bertone; Evelien E Bouwmans; Ana Cvejic; Rémi Favier; Gregory Jordan; Ross N W Kettleborough; Graham Kiddle; Myrto Kostadima; Alan Nurden; Paquita Nurden; Randy J Read; Augusto Rendon; Botond Sipos; Suthesh Sivapalaratnam; Peter A Smethurst; Jonathan Stephens; Katrin Voss; Willem H Ouwehand
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome.
Nature genetics 2011;43(8):735-7.
2011: Marloes R Tijssen; Ana Cvejic; Anagha Joshi; Rebecca L Hannah; Rita Ferreira; Ariel Forrai; Dana C Bellissimo; S Helen Oram; Peter A Smethurst; Nicola K Wilson; Xiaonan Wang; Katrin Ottersbach; Derek L Stemple; Anthony R Green; Willem H Ouwehand; Berthold Göttgens
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.
Developmental cell 2011;20(5):597-609.
2011: Ana Cvejic; Jovana Serbanovic-Canic; Derek L Stemple; Willem H Ouwehand
The role of meis1 in primitive and definitive hematopoiesis during zebrafish development.
Haematologica 2011;96(2):190-8.
2011: Suthesh Sivapalaratnam; Mieke D Trip; Rachel T van Beem; Nicholas A Watkins; Jaap-Jan Zwaginga; Rosienne Farrugia; Arief Gusnanto; Cordelia F Langford; Stephanie Maiwald; Max Nieuwdorp; Willem H Ouwehand
Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study.
BMC medical genomics 2011;4():64.
2010: Alison H Goodall; Philippa Burns; Isabelle I Salles; Iain Macaulay; Chris I Jones; Diego Ardissino; Bernard de Bono; Sarah L Bray; Hans Deckmyn; Frank Dudbridge; Desmond J Fitzgerald; Stephen F Garner; Arief Gusnanto; Kerstin Koch; Cordelia Langford; Marie N O'Connor; Catherine M Rice; Derek Stemple; Jonathan Stephens; Mieke D Trip; Jaap-Jan Zwaginga; Nilesh J Samani; Nicholas A Watkins; Patricia B Maguire; Willem H Ouwehand
Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.
Blood 2010;116(22):4646-56.
2010: Nicola K Wilson; Samuel D Foster; Xiaonan Wang; Kathy Knezevic; Judith Schütte; Polynikis Kaimakis; Paulina M Chilarska; Sarah Kinston; Willem H Ouwehand; Elaine Dzierzak; John E Pimanda; Marella F T R de Bruijn; Berthold Göttgens
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.
Cell stem cell 2010;7(4):532-44.
2010: Nadeem Sarwar; Manjinder S Sandhu; Sally L Ricketts; Adam S Butterworth; Emanuele Di Angelantonio; S Matthijs Boekholdt; Willem H Ouwehand; Hugh Watkins; Nilesh J Samani; Danish Saleheen; Debbie Lawlor; Muredach P Reilly; Aroon D Hingorani; Philippa J Talmud; John Danesh
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
Lancet 2010;375(9726):1634-9.
2009: Cedric Ghevaert; Angela Rankin; Elly Huiskes; Leendert Porcelijn; Kaija Javela; riitta marjut kekomaki; Tamam Bakchoul; Sentot Santoso; Sarah Nutland; Deborah J Smyth; Graham Smith; Simon McBride; Nicholas A Watkins; Willem H Ouwehand
Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.
Transfusion 2009;49(10):2084-9.
2009: Chris I Jones; Sarah Bray; Stephen F Garner; Jonathan Stephens; Bernard de Bono; Will G J Angenent; David Bentley; Philippa Burns; Alison Coffey; Panos Deloukas; Mark Earthrowl; Richard W Farndale; Marc F Hoylaerts; Kerstin Koch; Angela Rankin; Catherine M Rice; Jane Rogers; Nilesh J Samani; Michael Steward; Adam Walker; Nicholas A Watkins; Jan-Willem Akkerman; Frank Dudbridge; Alison H Goodall; Willem H Ouwehand
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Blood 2009;114(7):1405-16.
2009: Willem H Ouwehand
The discovery of genes implicated in myocardial infarction.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():305-7.
2009: Elisabeth Schaffner-Reckinger; Alexandre Salsmann; Najet Debili; J Bellis; J De Mey; William Vainchenker; Willem H Ouwehand; NELLY KIEFFER
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.
Journal of thrombosis and haemostasis : JTH 2009;7(7):1207-17.
2009: Marie N O'Connor; Isabelle I Salles; Ana Cvejic; Nicholas A Watkins; Adam Walker; Stephen F Garner; Chris I Jones; Iain Macaulay; Michael Steward; Jaap-Jan Zwaginga; Sarah L Bray; Frank Dudbridge; Bernard de Bono; Alison H Goodall; Hans Deckmyn; Derek L Stemple; Willem H Ouwehand
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins.
Blood 2009;113(19):4754-62.
2009: Paul Metcalfe; D Allen; riitta marjut kekomaki; Cécile Kaplan; Masja de Haas; Willem H Ouwehand
An International Reference Reagent (minimum sensitivity) for the detection of anti-human platelet antigen 1a.
Vox sanguinis 2009;96(2):146-52.
2008: Cedric Ghevaert; David A Wilcox; Juan Fang; Kathryn Armour; Michael R Clark; Willem H Ouwehand; Lorna M Williamson
Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia.
The Journal of clinical investigation 2008;118(8):2929-38.
2008: Philippa Burns; Arief Gusnanto; Iain Macaulay; Angela Rankin; Brian Tom; Cordelia F Langford; Frank Dudbridge; Willem H Ouwehand; Nicholas A Watkins
Identification of variation in the platelet transcriptome associated with glycoprotein 6 haplotype.
Platelets 2008;19(4):258-67.
2008: Stephen F Garner; Chris I Jones; Jonathan Stephens; Philippa Burns; Jill Walton; Adam Bernard; Will Angenent; Willem H Ouwehand; Alison H Goodall
Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality.
Transfusion 2008;48(4):673-80.
2008: Cedric Ghevaert; Alexandre Salsmann; Nicholas A Watkins; Elisabeth Schaffner-Reckinger; Angela Rankin; Stephen F Garner; Jonathan Stephens; Graham Smith; Najet Debili; William Vainchenker; Philip G de Groot; James A Huntington; Mike Laffan; NELLY KIEFFER; Willem H Ouwehand
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
Blood 2008;111(7):3407-14.
2008: Prachi Stafford; Cedric Ghevaert; Kate Campbell; C Proulx; Graham Smith; Lorna M Williamson; Edmund Ranasinghe; Nicholas A Watkins; James A Huntington; Willem H Ouwehand
Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.
Journal of thrombosis and haemostasis : JTH 2008;6(2):366-75.
2008: Prachi Stafford; Stephen F Garner; E Huiskes; Cécile Kaplan; riitta marjut kekomaki; S Santoso; N H Tsuno; Nicholas A Watkins; Willem H Ouwehand
Three novel beta3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency beta3-HPA antibodies.
Journal of thrombosis and haemostasis : JTH 2008;6(2):376-83.
2007: Graham Smith; Angela Rankin; C Riddle; C Cheetham-Wilkinson; Edmund Ranasinghe; Willem H Ouwehand; Nicholas A Watkins
Severe fetomaternal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a in a mother with a rare and silenced ITGB3*0101 (GPIIIa) allele.
Vox sanguinis 2007;93(4):325-30.
2007: D Allen; Willem H Ouwehand; Masja de Haas; riitta marjut kekomaki; Cécile Kaplan; Paul Metcalfe
Interlaboratory variation in the detection of HPA-specific alloantibodies and in molecular HPA typing.
Vox sanguinis 2007;93(4):316-24.
2007: J Berry; D Allen; Leendert Porcelijn; Masja de Haas; riitta marjut kekomaki; Cécile Kaplan; Willem H Ouwehand; Paul Metcalfe
Collaborative studies to establish the first World Health Organization International Standard for detection of human antibody against human platelet antigen-3a.
Vox sanguinis 2007;93(4):309-15.
2007: Graham Smith; Edmund Ranasinghe; Willem H Ouwehand
The importance of using multiple techniques for detection of platelet antibodies.
Vox sanguinis 2007;93(4):306-8.
2007: Z Foxcroft; K Campbell; Yves Merieux; Stanislaw J Urbaniak; M Brierley; D Rigal; Willem H Ouwehand; P Metcalfe
Report on the 13th International Society of Blood Transfusion Platelet Immunology Workshop.
Vox sanguinis 2007;93(4):300-5.
2007: Cécile Kaplan; J Freedman; Z Foxcroft; Anne Husebekk; P Metcalfe; E Muniz-Diaz; Willem H Ouwehand; S Panzer; Primoz Rozman; Bjørn Skogen
Monoclonal platelet antigen capture assays (MAIPA) and reagents: a statement.
Vox sanguinis 2007;93(4):298-9.
2007: Kate Campbell; K Rishi; G Howkins; D Gilby; R Mushens; Cedric Ghevaert; Paul Metcalfe; Willem H Ouwehand; G Lucas
A modified rapid monoclonal antibody-specific immobilization of platelet antigen assay for the detection of human platelet antigen (HPA) antibodies: a multicentre evaluation.
Vox sanguinis 2007;93(4):289-97.
2007: Chris I Jones; Stephen F Garner; W Angenent; A Bernard; Carlo Berzuini; Philippa Burns; Richard W Farndale; J Hogwood; Angela Rankin; JC Stephens; B D Tom; J Walton; Frank Dudbridge; Willem H Ouwehand; Alison H Goodall
Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus.
Journal of thrombosis and haemostasis : JTH 2007;5(8):1756-65.
2007: Willem H Ouwehand
Platelet genomics and the risk of atherothrombosis.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():188-95.
2007: Cedric Ghevaert; Kate Campbell; Prachi Stafford; Paul Metcalfe; Angela C Casbard; Graham Smith; Dave Allen; Edmund Ranasinghe; Lorna M Williamson; Willem H Ouwehand
HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia.
Transfusion 2007;47(7):1296-305.
2007: Arief Gusnanto; Brian Tom; Philippa Burns; Iain Macaulay; Daphne C Thijssen-Timmer; Marloes R Tijssen; Cordelia Langford; Nicholas A Watkins; Willem H Ouwehand; Carlo Berzuini; Frank Dudbridge
Improving the power to detect differentially expressed genes in comparative microarray experiments by including information from self-self hybridizations.
Computational biology and chemistry 2007;31(3):178-85.
2007: Stephen A Newland; Iain Macaulay; Andres R Floto; Edwin C J M De Vet; Willem H Ouwehand; Nicholas A Watkins; Paul A Lyons; Duncan R Campbell
The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.
Blood 2007;109(11):4806-9.
2007: Cedric Ghevaert; Kate Campbell; Jill Walton; Graham Smith; Dave Allen; Lorna M Williamson; Willem H Ouwehand; Edmund Ranasinghe
Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia.
Transfusion 2007;47(5):901-10.
2007: Iain Macaulay; Marloes R Tijssen; Daphne C Thijssen-Timmer; Arief Gusnanto; Michael Steward; Philippa Burns; Cordelia F Langford; Peter D Ellis; Frank Dudbridge; Jaap-Jan Zwaginga; Nicholas A Watkins; C Ellen van der Schoot; Willem H Ouwehand
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Blood 2007;109(8):3260-9.
2007: Nicola S Jennings; Ian J Harmer; Kate Campbell; Prachi Stafford; Graham Smith; Paul Metcalfe; M Ann Benton; Judith C W Marsh; Willem H Ouwehand
Molecular characterization of the variable domains of an alphaIIbbeta3-specific immunoglobulin M kappa platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between alphaIIbbeta3 integrin antibodies.
Transfusion 2007;47(3):499-510.
2007: Peter A Smethurst; David J Onley; Gavin E Jarvis; Marie N O'Connor; C Graham Knight; Andrew B Herr; Willem H Ouwehand; Richard W Farndale
Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.
The Journal of biological chemistry 2007;282(2):1296-304.
2006: Marie N O'Connor; Peter A Smethurst; Lorna W Davies; Lotta Joutsi-Korhonen; David J Onley; Andrew B Herr; Richard W Farndale; Willem H Ouwehand
Selective blockade of glycoprotein VI clustering on collagen helices.
The Journal of biological chemistry 2006;281(44):33505-10.
2006: Nicola S Jennings; Peter A Smethurst; C Graham Knight; Marie N O'Connor; Lotta Joutsi-Korhonen; Prachi Stafford; Jonathan Stephens; Stephen F Garner; Ian J Harmer; Richard W Farndale; Nicholas A Watkins; Willem H Ouwehand
Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolation.
Journal of immunological methods 2006;316(1-2):75-83.
2006: Astrid Zahn; Nicola S Jennings; Willem H Ouwehand; Jean-Pierre Allain
Hepatitis C virus interacts with human platelet glycoprotein VI.
The Journal of general virology 2006;87(Pt 8):2243-51.
2006: Nicholas A Watkins; Marie N O'Connor; Angela Rankin; Nicola S Jennings; E Wilson; Ian J Harmer; L Davies; Peter A Smethurst; Frank Dudbridge; Richard W Farndale; Willem H Ouwehand
Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in-depth exon resequencing and genotyping with tag single nucleotide polymorphisms.
Journal of thrombosis and haemostasis : JTH 2006;4(6):1197-205.
2006: Sentot Santoso; Hartmut Kroll; Luminita-Cornelia Andrei-Selmer; Ines Socher; Angela Rankin; Evelyne Kretzschmar; Nicholas A Watkins; Willem H Ouwehand
A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.
Transfusion 2006;46(5):790-9.
2006: Marie N O'Connor; Peter A Smethurst; Richard W Farndale; Willem H Ouwehand
Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen.
Journal of thrombosis and haemostasis : JTH 2006;4(4):869-73.
2005: Darren L Hughes; Prachi Stafford; Samir W Hamaia; lan J Harmer; Anne Schoolmeester; Hans Deckmyn; Richard W Farndale; Willem H Ouwehand; Nicholas A Watkins
Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display.
Thrombosis and haemostasis 2005;94(6):1318-26.
2005: Iain Macaulay; Philippa Carr; Arief Gusnanto; Willem H Ouwehand; Des Fitzgerald; Nicholas A Watkins
Platelet genomics and proteomics in human health and disease.
The Journal of clinical investigation 2005;115(12):3370-7.
2005: R Andres Floto; Menna R Clatworthy; Karen R Heilbronn; Dalya R Rosner; Paul A MacAry; Angela Rankin; Paul J Lehner; Willem H Ouwehand; Janet M Allen; Nicholas A Watkins; Kenneth G C Smith
Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.
Nature medicine 2005;11(10):1056-8.
2005: D Allen; P Rigsby; Hagop Bessos; J Berry; David Wilson; Willem H Ouwehand; Stanislaw J Urbaniak; Paul Metcalfe
Collaborative study to establish the first international standard for quantitation of anti-HPA-1a.
Vox sanguinis 2005;89(2):100-4.
2005: Sandra Penz; Armin J Reininger; Richard Brandl; Pankaj Goyal; Tamer Rabie; Isabell Bernlochner; Enno Rother; Christine Goetz; Bernd Engelmann; Peter A Smethurst; Willem H Ouwehand; Richard W Farndale; Bernhard Nieswandt; Wolfgang Siess
Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):898-909.
2005: Stephen F Garner; Kate Campbell; Graham Smith; Colin Hurd; Simon J Davidson; Marilyn Treacy; John F Burman; Hartmut Kroll; Willem H Ouwehand
Teicoplanin-dependent antibodies: detection and characterization.
British journal of haematology 2005;129(2):279-81.
2004: Pia R-M Siljander; Samir W Hamaia; Anthony R Peachey; David A Slatter; Peter A Smethurst; Willem H Ouwehand; C Graham Knight; Richard W Farndale
Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens.
The Journal of biological chemistry 2004;279(46):47763-72.
2004: Willem H Ouwehand; Nicholas A Watkins; Stephen F Garner; Peter A Smethurst
Monoclonal antibody therapies in transfusion medicine.
Vox sanguinis 2004;87 Suppl 2():151-4.
2004: Willem H Ouwehand; T B Wallington
Adaptive immunity and transfusion.
Vox sanguinis 2004;87 Suppl1():35-8.
2004: Alexander D Barrow; Emmanuelle Astoul; Andres Floto; Gary Brooke; Ingrid A M Relou; Nicola S Jennings; Kenneth G C Smith; Willem H Ouwehand; Richard W Farndale; Denis R Alexander; John Trowsdale
Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5838-42.
2004: Lotta Joutsi-Korhonen; Sandy Preston; Peter A Smethurst; Martin J W IJsseldijk; Elisabeth Schaffner-Reckinger; Kathryn Armour; Nicholas A Watkins; Michael R Clark; Philip G de Groot; Richard W Farndale; Willem H Ouwehand; Lorna M Williamson
The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.
Thrombosis and haemostasis 2004;91(4):743-54.
2004: Nicholas A Watkins; Timothy R Dafforn; M Kuijpers; C Brown; Babak Javid; Paul J Lehner; C Navarrete; Willem H Ouwehand
Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.
Tissue antigens 2004;63(4):345-54.
2004: Pia R-M Siljander; Imke C A Munnix; Peter A Smethurst; Hans Deckmyn; Theo Lindhout; Willem H Ouwehand; Richard W Farndale; Johan W M Heemskerk
Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood.
Blood 2004;103(4):1333-41.
2004: Peter A Smethurst; Lotta Joutsi-Korhonen; Marie N O'Connor; Erica Wilson; Nicola S Jennings; Stephen F Garner; Yanjun Zhang; C Graham Knight; Timothy R Dafforn; Ashley Buckle; Martin J W IJsseldijk; Philip G de Groot; Nicholas A Watkins; Richard W Farndale; Willem H Ouwehand
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody.
Blood 2004;103(3):903-11.
2003: Paul Metcalfe; N A Watkins; Willem H Ouwehand; Cécile Kaplan; P Newman; riitta marjut kekomaki; Masja de Haas; R Aster; Y Shibata; J Smith; Volker Kiefel; Sentot Santoso
Nomenclature of human platelet antigens.
Vox sanguinis 2003;85(3):240-5.
2003: Nicholas A Watkins; Lily M Du; J Paul Scott; Willem H Ouwehand; Cheryl A Hillery
Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion.
Blood 2003;102(2):718-24.
2003: Lotta Joutsi-Korhonen; Peter A Smethurst; Angela Rankin; Elaine Gray; Martin J W IJsseldijk; Catherine M Onley; Nicholas A Watkins; Lorna M Williamson; Alison H Goodall; Philip G de Groot; Richard W Farndale; Willem H Ouwehand
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression.
Blood 2003;101(11):4372-9.
2003: Paul Metcalfe; Willem H Ouwehand; Dawn Sands; Trevor Barrowcliffe
Collaborative studies to establish the first WHO Reference Reagent for detection of human antibody against human platelet antigen-5b.
Vox sanguinis 2003;84(3):237-40.
2002: Colin Hurd; Gary Cavanagh; A Schuh; Willem H Ouwehand; Paul Metcalfe
Genotyping for platelet-specific antigens: techniques for the detection of single nucleotide polymorphisms.
Vox sanguinis 2002;83(1):1-12.
2002: Stephen F Garner; Kate Campbell; Paul Metcalfe; Jane Keidan; Elly Huiskes; Jing-fei Dong; José A López; Willem H Ouwehand
Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia.
Blood 2002;100(1):344-6.
2002: Nicholas A Watkins; Elisabeth Schaffner-Reckinger; David L Allen; Graham J Howkins; nicolaas brons; Graham Smith; Paul Metcalfe; Michael F Murphy; NELLY KIEFFER; Willem H Ouwehand
HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.
Blood 2002;99(5):1833-9.
2002: Andre C Schuh; Nick A Watkins; Quang Nguyen; Nicholas J Harmer; Martin Lin; Joseph Y A Prosper; Kate Campbell; D Robert Sutherland; Paul Metcalfe; Wendy Horsfall; Willem H Ouwehand
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.
Blood 2002;99(5):1692-8.
2002: Nicholas A Watkins; Peter A Smethurst; David Allen; Graham Smith; Willem H Ouwehand
Platelet alphaIIbbeta3 recombinant autoantibodies from the B-cell repertoire of a post-transfusion purpura patient.
British journal of haematology 2002;116(3):677-85.
2001: CQ Li; P Ye; H Wang; L Lu; P Nicastro; E Wood; J J Robert; Willem H Ouwehand; F Hill; J A López; Mark Wardell
Expression of the amino-terminal domain of platelet glycoprotein Ib alpha: exploitation of a calmodulin tag for determination of its functional activity.
Protein expression and purification 2001;22(2):200-10.
2001: Edmund Ranasinghe; J D Walton; Colin Hurd; L Saul; Graham Smith; Kate Campbell; Willem H Ouwehand
Provision of platelet support for fetuses and neonates affected by severe fetomaternal alloimmune thrombocytopenia.
British journal of haematology 2001;113(1):40-2.
2000: J E Berry; C M Murphy; Graham Smith; Edmund Ranasinghe; R Finberg; J Walton; J Brown; C Navarrete; Paul Metcalfe; Willem H Ouwehand
Detection of Gov system antibodies by MAIPA reveals an immunogenicity similar to the HPA-5 alloantigens.
British journal of haematology 2000;110(3):735-42.
2000: Willem H Ouwehand; Graham Smith; Edmund Ranasinghe
Management of severe alloimmune thrombocytopenia in the newborn.
Archives of disease in childhood. Fetal and neonatal edition 2000;82(3):F173-5.
2000: Nicholas A Watkins; C Brown; Colin Hurd; C Navarrete; Willem H Ouwehand
The isolation and characterisation of human monoclonal HLA-A2 antibodies from an immune V gene phage display library.
Tissue antigens 2000;55(3):219-28.
2000: Stephen F Garner; Peter A Smethurst; Yves Merieux; C Aeby; Graham Smith; Kathryn Armour; M L Scott; Lorna M Williamson; Paul Metcalfe; Alison H Goodall; Michael R Clark; Dominique Rigal; M Schawaller; Willem H Ouwehand
A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a.
British journal of haematology 2000;108(2):440-7.
2000: Nicholas A Watkins; Willem H Ouwehand
Introduction to antibody engineering and phage display.
Vox sanguinis 2000;78(2):72-9.
2000: CQ Li; Stephen F Garner; J Davies; Peter A Smethurst; Mark Wardell; Willem H Ouwehand
Threonine-145/methionine-145 variants of baculovirus produced recombinant ligand binding domain of GPIbalpha express HPA-2 epitopes and show equal binding of von Willebrand factor.
Blood 2000;95(1):205-11.
1999: Nicholas A Watkins; Kathryn Armour; Peter A Smethurst; Paul Metcalfe; M L Scott; Darren L Hughes; Graham Smith; Lorna M Williamson; Michael R Clark; Willem H Ouwehand
Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays.
Transfusion 1999;39(7):781-9.
1999: N C Hughes-Jones; J M Bye; B D Gorick; James D Marks; Willem H Ouwehand
Synthesis of Rh Fv phage-antibodies using VH and VL germline genes.
British journal of haematology 1999;105(3):811-6.
1999: panos kottaridis; H Rees; Graham Smith; S F Garner; AR Perry; Andrew J Peniket; Anthony H Goldstone; Stephen Mackinnon; Willem H Ouwehand
A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation.
Bone marrow transplantation 1999;23(7):739-41.
1999: Paul Metcalfe; Gary Cavanagh; Colin Hurd; Willem H Ouwehand
HPA genotyping by PCR-SSP: report of 4 exercises.
Vox sanguinis 1999;77(1):40-3.
1998: M C Dooren; Willem H Ouwehand; A J Verhoeven; Albert E G Kr von dem Borne; R W Kuijpers
Adult respiratory distress syndrome after experimental intravenous gamma-globulin concentrate and monocyte-reactive IgG antibodies.
Lancet 1998;352(9140):1601-2.
1998: Lorna M Williamson; Gerald Hackett; J Rennie; Christopher R Palmer; C Maciver; Ruth Hadfield; D Hughes; S Jobson; Willem H Ouwehand
The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening.
Blood 1998;92(7):2280-7.
1998: Willem H Ouwehand; Nicholas A Watkins
Novel diagnostic and therapeutic strategies with genetically engineered human antibodies.
Vox sanguinis 1998;74 Suppl 2():223-32.
1997: Paul Metcalfe; Lorna M Williamson; C P Reutelingsperger; Ian David Swann; Willem H Ouwehand; Alison H Goodall
Activation during preparation of therapeutic platelets affects deterioration during storage: a comparative flow cytometric study of different production methods.
British journal of haematology 1997;98(1):86-95.
1997: nay win; Willem H Ouwehand; Colin Hurd
Provision of platelets for severe neonatal alloimmune thrombocytopenia.
British journal of haematology 1997;97(4):930-2.
1997: Paul Metcalfe; D Allen; J Chapman; Willem H Ouwehand
Interlaboratory variation in the detection of clinically significant alloantibodies against human platelet alloantigens.
British journal of haematology 1997;97(1):204-7.
1997: R Finnern; E Pedrollo; Igor Fisch; J Wieslander; J D Marks; CM Lockwood; Willem H Ouwehand
Human autoimmune anti-proteinase 3 scFv from a phage display library.
Clinical and experimental immunology 1997;107(2):269-81.
1996: Ruud M T de Wildt; R Finnern; Willem H Ouwehand; A D Griffiths; Walther J van Venrooij; René M A Hoet
Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and patient-derived combinatorial V gene library.
European journal of immunology 1996;26(3):629-39.
1995: H M Griffin; Willem H Ouwehand
A human monoclonal antibody specific for the leucine-33 (P1A1, HPA-1a) form of platelet glycoprotein IIIa from a V gene phage display library.
Blood 1995;86(12):4430-6.
1995: Paul Metcalfe; P M Bleeker; A E von dem Borne; Willem H Ouwehand
Human platelet antigen-2 and -3 genotyping by PCR-SSP.
Transfusion medicine (Oxford, England) 1995;5(4):285-8.
1995: R Finnern; J M Bye; K M Dolman; M H Zhao; A Short; James D Marks; M C Lockwood; Willem H Ouwehand
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Clinical and experimental immunology 1995;102(3):566-74.
1994: N C Hughes-Jones; B D Gorick; J M Bye; R Finnern; M L Scott; D Voak; James D Marks; Willem H Ouwehand
Characterization of human blood group scFv antibodies derived from a V gene phage-display library.
British journal of haematology 1994;88(1):180-6.
1994: C P Engelfriet; M A M Overbeeke; M C Dooren; Willem H Ouwehand; Albert E G Kr von dem Borne
Bioassays to determine the clinical significance of red cell alloantibodies based on Fc receptor-induced destruction of red cells sensitized by IgG.
Transfusion 1994;34(7):617-26.
1994: M C Dooren; Inge L van Kamp; J W Scherpenisse; Ronald Brand; Willem H Ouwehand; Humphrey H H Kanhai; C P Engelfriet; J B Gravenhorst
No beneficial effect of low-dose fetal intravenous gammaglobulin administration in combination with intravascular transfusions in severe Rh D haemolytic disease.
Vox sanguinis 1994;66(4):253-7.
1994: Willem H Ouwehand; J M Bye; B D Gorick; James D Marks; E Timmers; H M Griffin; R Finnern; N Hughes-Jones
The humoral immune response against blood group antigens at the molecular level.
Vox sanguinis 1994;67 Suppl 3():7-12.
1993: James D Marks; Willem H Ouwehand; J M Bye; R Finnern; B D Gorick; D Voak; S J Thorpe; N C Hughes-Jones; Greg Winter
Human antibody fragments specific for human blood group antigens from a phage display library.
Bio/technology (Nature Publishing Company) 1993;11(10):1145-9.
1993: B Gorick; D C McDougall; Willem H Ouwehand; M A M Overbeeke; P Tippett; N C Hughes-Jones; Dick J van Rhenen
Quantitation of D sites on selected 'weak D' and 'partial D' red cells.
Vox sanguinis 1993;65(2):136-40.
1992: Lorna M Williamson; D Bruce; A Lubenko; H J Chana; Willem H Ouwehand
Molecular biology for platelet alloantigen typing.
Transfusion medicine (Oxford, England) 1992;2(4):255-64.
1992: M F Murphy; B Brozovic; W Murphy; Willem H Ouwehand; A H Waters
Guidelines for platelet transfusions. British Committee for Standards in Haematology, Working Party of the Blood Transfusion Task Force.
Transfusion medicine (Oxford, England) 1992;2(4):311-8.
1992: R W Kuijpers; Albert E G Kr von dem Borne; V Kiefel; C M Eckhardt; A H Waters; B Zupanska; D Barz; Ellen Taaning; A Termijtelen; Willem H Ouwehand
Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).
Human immunology 1992;34(4):253-6.
1992: M C Dooren; R W Kuijpers; E C Joekes; E Huiskes; roel goldschmeding; M A M Overbeeke; Albert E G Kr von dem Borne; C P Engelfriet; Willem H Ouwehand
Protection against immune haemolytic disease of newborn infants by maternal monocyte-reactive IgG alloantibodies (anti-HLA-DR).
Lancet 1992;339(8801):1067-70.
1992: R W Kuijpers; N M Faber; H Theo M Cuypers; Willem H Ouwehand; Albert E G Kr von dem Borne
NH2-terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens.
The Journal of clinical investigation 1992;89(2):381-4.
1992: R W Kuijpers; Willem H Ouwehand; W Peelen; J J Michiels; C P Engelfriet; Albert E G Kr von dem Borne
Thrombocytopenia due to platelet glycoprotein IIb/IIIa-reactive autoantibodies non-reactive with platelets from EDTA blood.
Vox sanguinis 1992;63(2):119-21.
1992: R W Kuijpers; Willem H Ouwehand; P M Bleeker; D Christie; Albert E G Kr von dem Borne
Localization of the platelet-specific HPA-2 (Ko) alloantigens on the N-terminal globular fragment of platelet glycoprotein Ib alpha.
Blood 1992;79(1):283-8.
1991: R W Kuijpers; M C Dooren; Albert E G Kr von dem Borne; Willem H Ouwehand
Detection of human monocyte-reactive alloantibodies by flow cytometry after selective downmodulation of the Fc receptor I.
Blood 1991;78(8):2150-6.
1991: G J Tijhuis; R J Klaassen; P W Modderman; Willem H Ouwehand; Albert E G Kr von dem Borne
Quantification of platelet-bound immunoglobulins of different class and subclass using radiolabelled monoclonal antibodies: assay conditions and clinical application.
British journal of haematology 1991;77(1):93-101.
1990: T Baglin; Willem H Ouwehand; D Voak; A H Waters; H H Gunson; E Lloyd
Bedside blood compatibility testing.
Lancet 1990;336(8724):1196-7.
1990: Albert E G Kr von dem Borne; Willem H Ouwehand; R W Kuijpers
Theoretic and practical aspects of platelet crossmatching.
Transfusion medicine reviews 1990;4(4):265-78.
1990: R J Klaassen; Willem H Ouwehand; Tom W J Huizinga; C P Engelfriet; Albert E G Kr von dem Borne
The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):599-606.
1990: Rob Fijnheer; P W Modderman; H Veldman; Willem H Ouwehand; H Karel Nieuwenhuis; Dirk Roos; D de Korte
Detection of platelet activation with monoclonal antibodies and flow cytometry. Changes during platelet storage.
Transfusion 1990;30(1):20-5.
1989: P W Modderman; Jan A van Mourik; W van Berkel; J L Cordell; M C Morel; Cécile Kaplan; Willem H Ouwehand; J G Huisman; Albert E G Kr von dem Borne
Decreased stability and structural heterogeneity of the residual platelet glycoprotein IIb/IIIa complex in a variant of Glanzmann's thrombasthenia.
British journal of haematology 1989;73(4):514-21.
1989: R J Klaassen; Willem H Ouwehand; Albert E G Kr von dem Borne
[Thrombocytopenia as single symptom of HIV-infection].
Nederlands tijdschrift voor geneeskunde 1989;133(45):2252-3.
1988: H A Brouwers; M A M Overbeeke; Willem H Ouwehand; K Keuning; I van Ertbruggen; EF van Leeuwen; J W Stoop; C P Engelfriet
Maternal antibodies against fetal blood group antigens A or B: lytic activity of IgG subclasses in monocyte-driven cytotoxicity and correlation with ABO haemolytic disease of the newborn.
British journal of haematology 1988;70(4):465-9.
1988: H A Brouwers; M A M Overbeeke; E Huiskes; M J Bos; Willem H Ouwehand; C P Engelfriet
Complement is not activated in ABO-haemolytic disease of the newborn.
British journal of haematology 1988;68(3):363-6.